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WO2020218840A1 - Composition pour inhiber la perte des cheveux ou favoriser la pousse des cheveux contenant un extrait de plante débarrassé de chlorophylle ou de pigment en tant que principe actif, et son procédé de production - Google Patents

Composition pour inhiber la perte des cheveux ou favoriser la pousse des cheveux contenant un extrait de plante débarrassé de chlorophylle ou de pigment en tant que principe actif, et son procédé de production Download PDF

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Publication number
WO2020218840A1
WO2020218840A1 PCT/KR2020/005359 KR2020005359W WO2020218840A1 WO 2020218840 A1 WO2020218840 A1 WO 2020218840A1 KR 2020005359 W KR2020005359 W KR 2020005359W WO 2020218840 A1 WO2020218840 A1 WO 2020218840A1
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Prior art keywords
extract
hair loss
floral water
chlorophyll
hair growth
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Ceased
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PCT/KR2020/005359
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English (en)
Korean (ko)
Inventor
배용태
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Bionewtech Co Ltd
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Bionewtech Co Ltd
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Publication of WO2020218840A1 publication Critical patent/WO2020218840A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention contains chlorophyll or pigment-removed polygonum cuspidatum extract, Camellia japonica leaf extract, and Artemisia annua extract as active ingredients, and green tea ( Camellia sinensis ) leaf extract, cypress Tree (Chamaecyparis obtusa) leaf extract and Eoseongcho ( Houttuynia cordata ) It relates to a composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract, and a method for preparing the same.
  • the scalp is composed of epidermis, dermis, and subcutaneous tissue, and the outermost tissue, the epidermis, functions to protect sensitive tissues of the body from damage.
  • the scalp function may be lost due to environmental factors affecting the scalp, such as stress and lack of influence due to external stimuli such as temperature change, humidity change, exposure to pollutants, etc., and may affect hair loss. .
  • Tissues associated with hair loss include sebaceous gland, keratinocytes of the epidermis and hair follicles, dermal papilla cells, sweat gland, and root sheath of the scalp hair follicle. have.
  • DHT dihydrotestosterone
  • Androgenetic alopecia is a phenomenon caused by a male hormone called testosterone.
  • testosterone When this testosterone is converted into dihydrotestosterone, a more powerful hormone by an enzyme called 5 ⁇ -reductase, this hormone acts on the hair follicles and It induces hair loss from the growth stage to the degenerative stage. Therefore, a method of inhibiting the production of DHT by 5-alpha-reductase is mainly used to treat androgenetic alopecia.
  • finasteride a 5-alpha-reductase inhibitor
  • DHT hair loss hormone
  • Tase is an important target for the treatment of hair loss and is used in the development of a hair loss treatment, and it is a pharmacologically active substance that treats alopecia by inhibiting the activity of 5-alpha-reductase, a biological enzyme involved in the reaction of dihydrotestosterone from testosterone.
  • 5-alpha-reductase a 5-alpha-reductase inhibitor
  • Gynecomastia occurs primarily due to a decrease in the amount of estrogen after menopause.
  • Minoxidil or estrogen is mainly used as a treatment for gynecomastia.
  • Alopecia areata is caused by autoimmune diseases, mental stress, or genetic predisposition. Such alopecia areata has a fundamentally different cause from androgenetic alopecia, and treatment is also different, so a method of treating adrenocorticosteroids, applying minoxidil to the affected area, or artificially inducing irritation to the affected area is used.
  • hormone replacement therapy has been used as the most effective method.
  • a hormone such as estrogen
  • cancer such as breast cancer and uterine cancer
  • side effects such as headache and weight gain occur.
  • the present inventors were studying plant extracts having excellent safety and no side effects while inhibiting hair loss or promoting hair growth, and extracts of Hojanggeun, Camellia leaf, Mugwort, Green tea leaf, Cypress leaf and Eoseongcho leaf It was confirmed that there is an effect of inhibiting hair loss or promoting hair growth, and thus the present invention was completed.
  • An object of the present invention is to provide a composition for inhibiting hair loss or promoting hair growth, and a method for producing the same, which is excellent in inhibiting hair loss or promoting hair growth, and has high safety and no side effects.
  • Another object of the present invention is to provide a method for inhibiting hair loss or promoting hair growth, comprising administering to an individual an extract having high safety and no side effects while having excellent hair loss inhibition or hair growth promoting effect of the present invention.
  • Another object of the present invention is to provide a use of an extract having high safety and no side effects while having excellent hair loss inhibition or hair growth promoting effect of the present invention for use as a composition for inhibiting hair loss or promoting hair growth.
  • the present invention provides a functional cosmetic composition for inhibiting hair loss or promoting hair growth, containing the extract as an active ingredient.
  • the present invention provides a quasi-drug composition for inhibiting hair loss or promoting hair growth, containing the extract as an active ingredient.
  • the present invention provides a pharmaceutical composition for inhibiting hair loss or promoting hair growth, containing the extract as an active ingredient.
  • the present invention provides a health food for inhibiting hair loss or promoting hair growth, containing the extract as an active ingredient.
  • the present invention provides a method for inhibiting hair loss or promoting hair growth, comprising administering to an individual a pharmaceutically effective amount of the extract.
  • the present invention provides the use of the extract for use as a composition for inhibiting hair loss or promoting hair growth.
  • the present invention provides the use of the extract for use as a functional cosmetic composition for inhibiting hair loss or promoting hair growth.
  • the present invention provides the use of the extract for use as a quasi-drug composition for inhibiting hair loss or promoting hair growth.
  • the present invention provides the use of the extract for use as a pharmaceutical composition for inhibiting hair loss or promoting hair growth.
  • the present invention provides the use of the extract for use as a health food for inhibiting hair loss or promoting hair growth.
  • Polygonum cuspidatum extract according to the present invention Camellia japonica leaf extract, and artemisia annua extract as active ingredients, green tea ( Camellia sinensis ) leaf extract, cypress tree (Chamaecyparis obtusa)
  • the composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract and Houttuynia cordata leaf extract is excellent in inhibiting hair loss or promoting hair growth, and at the same time has high safety and no side effects.
  • the extract can be usefully used as a composition for inhibiting hair loss or promoting hair growth.
  • 1 is a diagram showing a process of removing chlorophyll and pigment from a plant extract.
  • Figure 2 is a diagram showing the extract prepared in Example ⁇ 3-1> from which the pigment was removed.
  • FIG. 3 is a view showing a camellia leaf extract from which chlorophyll has been removed prepared according to Example ⁇ 3-2>.
  • Figure 4 is a diagram showing a wormwood extract prepared according to Example ⁇ 3-3> from which chlorophyll was removed.
  • FIG. 5 is a diagram showing a green tea leaf extract from which chlorophyll is removed prepared according to Example ⁇ 3-4>.
  • FIG. 6 is a view showing a cypress leaf extract from which chlorophyll was removed prepared according to Example ⁇ 3-5>.
  • Example 7 is a diagram showing a leaf extract of Eoseongcho from which chlorophyll was removed prepared according to Example ⁇ 3-6>.
  • FIG. 8 is a diagram showing a composition for inhibiting hair loss or promoting hair growth in a mist form prepared according to ⁇ Preparation Example 1>.
  • FIG. 9 is a diagram showing a composition for inhibiting hair loss or promoting hair growth in the form of a shampoo prepared according to ⁇ Preparation Example 2>.
  • FIG. 10 shows new hair on the crown, which is a wide range of circular hair loss sites of User 1, who used the mist and shampoo prepared according to ⁇ Preparation Example 1> and ⁇ Preparation Example 2> for a total of 3 years from March 2016 to March 2019. Is a diagram showing the generated state.
  • FIG. 11 is a diagram showing the hair condition of User 2, who used the shampoo prepared according to ⁇ Preparation Example 1> and ⁇ Preparation Example 2> for a total of 16 months from February 2017 to June 2018.
  • FIG. 12 is a diagram showing a state in which hair that was not generated on the right forehead of User 3, who used the mist prepared according to ⁇ Production Example 1> for 14 months, was generated.
  • FIG. 13 is a diagram showing a state in which hair that was not generated on the left forehead of User 3, who used the mist prepared according to ⁇ Production Example 1> for 14 months, was generated.
  • FIG. 14 is a diagram showing a state in which new hair is generated in a wide range of hair loss sites of User 4, who has used the shampoo prepared according to ⁇ Production Example 2> for about 40 days.
  • 15 is a diagram showing a state in which new hair is generated in a wide range of hair loss sites of User 5, who has used the shampoo prepared according to ⁇ Production Example 2> for about 40 days.
  • 16 is a diagram showing the pores of User 6 using the shampoo prepared according to ⁇ Preparation Example 2>.
  • FIG. 17 is a diagram showing the pores of User 7 who used the shampoo prepared according to ⁇ Production Example 2>.
  • the present invention comprises a polygonum cuspidatum extract, Camellia japonica leaf extract, and artemisia annua extract as active ingredients, green tea ( Camellia sinensis ) leaf extract, cypress tree ( Chamaecyparis obtusa ) leaf It provides a composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of extracts and Eoseongcho ( Houttuynia cordata ) leaf extracts.
  • the present invention provides the use of the extract for use as a composition for inhibiting hair loss or promoting hair growth.
  • the extract is chlorophyll extracted by mixing with an extraction solvent consisting of at least one floral water selected from the group consisting of floral water extracted from Maengjongjuk leaves, floral water extracted from Sinuidae leaves, and floral water extracted from cypress leaves, and fermented alcohol.
  • an extraction solvent consisting of at least one floral water selected from the group consisting of floral water extracted from Maengjongjuk leaves, floral water extracted from Sinuidae leaves, and floral water extracted from cypress leaves, and fermented alcohol.
  • it may be a hair loss inhibiting or hair growth promoting species composition, characterized in that the extract from which the pigment has been removed, but is not limited thereto.
  • the chlorophyll extract has been removed from the pigment, and the camellia leaf extract, mugwort extract, green tea leaf extract, cypress leaf extract, and Eoseongcho leaf extract have chlorophyll removed.
  • the chlorophyll or pigment-removed hojanggeun extract, camellia leaf extract, wormwood extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract are preferably prepared by the following steps, but are not limited thereto.
  • the leaves of the hawthorn, camellia leaves, wormwood wormwood, green tea leaves, cypress leaves or Eoseongcho leaves of step 1) can be used without limitation, such as those grown or commercially available.
  • the extraction solvent of step 1) is preferably water, alcohol, or a mixture thereof, but is not limited thereto. It is preferable to use a lower alcohol of C 1 to C 2 as the alcohol, and it is preferable to use ethanol or methanol as the lower alcohol, but is not limited thereto.
  • the extraction method is preferably shaking extraction or reflux extraction, but is not limited thereto. It is preferable to extract by adding the extraction solvent 2 to 10 times to the amount of green tea leaves, camellia leaves, or gooseberries, but is not limited thereto.
  • the extraction temperature is preferably from room temperature to 50°C, but is not limited thereto.
  • the extraction time is preferably 2 to 5 days, but is not limited thereto.
  • the number of extractions is preferably 1 to 3 times, but is not limited thereto.
  • the vacuum concentration in step 3) is preferably a vacuum vacuum concentrator or a vacuum rotary evaporator, but is not limited thereto.
  • the floral water extracted from the wormwood in step 4), the floral water extracted from the green tea leaves, the floral water extracted from the camellia leaves, the floral water extracted from Maengjongjuk, the floral water extracted from Shin Medical University, or the floral water extracted from cypress leaves were mixed with ethanol. After mixing in a ratio of 9:1 to 7:3, it was diluted by adding 20 to 25 times to the concentrated extract of step 3), and then allowed to stand for 10 to 14 hours in freezing conditions at -40 to -60°C to precipitate It is preferable to separate the chlorophyll or pigment, but is not limited thereto.
  • the method is a method of extracting water-soluble and fat-soluble plant extracts from which chlorophyll or pigment has been removed.
  • the method is a method of extracting a water-soluble plant extract from which chlorophyll or pigment has been removed.
  • a colorant-removed hojanggeun extract by mixing the extract with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves. It is not limited.
  • camellia leaf extract from which chlorophyll has been removed by mixing the camellia leaf extract with floral water extracted from wormwood, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, and floral water extracted from cypress leaves.
  • floral water extracted from wormwood floral water extracted from camellia leaves
  • floral water extracted from Maengjongjuk floral water extracted from Maengjongjuk
  • floral water extracted from cypress leaves floral water extracted from wormwood, floral water extracted from camellia leaves, floral water extracted from Maengjongjuk, and floral water extracted from cypress leaves.
  • floral water extracted from wormwood floral water extracted from camellia leaves
  • floral water extracted from Maengjongjuk floral water extracted from Maengjongjuk
  • floral water extracted from cypress leaves floral water extracted from cypress leaves
  • the wormwood extract is preferably mixed with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves to prepare a wormwood extract from which chlorophyll is removed. It is not limited.
  • the green tea leaf extract is preferably mixed with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves to prepare a green tea leaf extract from which chlorophyll has been removed. It is not limited.
  • a cypress leaf extract from which chlorophyll is removed by mixing the cypress tree leaf extract with floral water extracted from wormwood, floral water extracted from Maengjongjuk, floral water extracted from Shin Medical University, and floral water extracted from cypress leaves. , But is not limited thereto.
  • the Eoseongcho leaf extract is preferably mixed with floral water extracted from wormwood wormwood, floral water extracted from Maengjongjuk, floral water extracted from Sinuidae, and floral water extracted from cypress leaves to prepare Eoseongcho leaf extract from which chlorophyll has been removed. It is not limited.
  • the concentration of the plant extract from which the chlorophyll or pigment of the present invention is removed is 0.01 to 5 mg/ml.
  • the present invention provides the use of the extract for use as a functional cosmetic composition for inhibiting hair loss or promoting hair growth.
  • the cosmetic composition may be, for example, a solution, a gel, an anhydrous product of a solid or dough, an emulsion obtained by dispersing an oil phase in an aqueous phase, a suspension, a microemulsion, a microcapsule, a microgranular sphere or an ionic (liposome), a nonionic vesicle dispersant It may be provided in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. In addition, it may be prepared in the form of a foam or an aerosol composition further containing a compressed propellant.
  • the cosmetic composition is a fatty substance, an organic solvent, a solubilizer, a thickening agent and a gelling agent, an emollient, an antioxidant, a suspending agent, a stabilizer, a foaming agent in addition to the plant extract from which the chlorophyll or pigment of the present invention is removed.
  • Fragrances surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles Or it may contain adjuvants commonly used in the field of cosmetics, such as any other ingredients commonly used in cosmetics.
  • It may be a quasi-drug composition for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, but is not limited thereto.
  • the present invention provides the use of the extract for use as a quasi-drug composition for inhibiting hair loss or promoting hair growth.
  • quadsi-drug used in the present invention refers to items that are not instruments, machines, or devices among items used for the purpose of diagnosing, treating, improving, reducing, treating or preventing diseases of humans or animals, and structures and functions of humans or animals. It refers to items other than instruments, machines, or devices used for the purpose of having a pharmacological effect on the skin, and includes skin preparations and personal hygiene products.
  • the quasi-drug composition When the quasi-drug composition is included in a quasi-drug for the purpose of preventing or improving hair loss, promoting hair growth or hair growth, the composition may be used as it is or may be used together with other quasi-drug ingredients, and may be appropriately used according to conventional methods. have.
  • the mixing amount of the active ingredient can be appropriately adjusted according to the purpose of use.
  • the quasi-drug product of the present invention is not particularly limited thereto, but may be prepared and used in the form of, for example, a cream, lotion, aerosol, shampoo, gel or pack. Further, if necessary, a stabilizer, a preservative, an absorption accelerator, a pH adjuster, and other suitable additives may be blended.
  • the present invention provides the use of the extract for use as a pharmaceutical composition for inhibiting hair loss or promoting hair growth.
  • the pharmaceutical composition may contain a pharmaceutically acceptable carrier.
  • the composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral formulations. In the case of formulation, it is prepared using diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, and surfactants that are usually used.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and these solid preparations contain at least one excipient, such as starch, calcium carbonate, sucrose or lactose, gelatin, etc. in one or more compounds. It is prepared by mixing. Further, in addition to simple excipients, lubricants such as magnesium stearate and talc may also be used.
  • Liquid preparations for oral administration include suspensions, liquid solutions, emulsions, and syrups.In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as humectants, sweeteners, fragrances, and preservatives may be included. have.
  • Preparations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized preparations, and suppositories.
  • the non-aqueous solvent and the suspension solvent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used.
  • a base for suppositories witepsol, macrogol, tween 61, cacao butter, laurin paper, glycerogelatin, and the like may be used.
  • the pharmaceutical composition is any selected from the group consisting of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations, and suppositories. It can have one formulation.
  • the pharmaceutical composition is administered in a pharmaceutically effective amount.
  • “Pharmaceutically effective amount” means an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is the type and severity of the subject, age, sex, activity of the drug, and Sensitivity, time of administration, route of administration and rate of excretion, duration of treatment, factors including co-used drugs and other factors well known in the medical field.
  • the pharmaceutical composition may be administered as an individual therapeutic agent or administered in combination with another therapeutic agent, and may be administered sequentially or simultaneously with a conventional therapeutic agent. And can be administered single or multiple. It is important to administer an amount capable of obtaining the maximum effect in a minimum amount without side effects in consideration of all the above factors, and can be easily determined by a person skilled in the art.
  • the route of administration of the pharmaceutical composition may be administered through any general route as long as it can reach the target tissue.
  • intraperitoneal administration intravenous administration, intramuscular administration, subcutaneous administration, intradermal administration, oral administration, intranasal administration, intrapulmonary administration, or rectal administration may be performed, but are not limited thereto.
  • It may be a health food for inhibiting hair loss or promoting hair growth containing the extract as an active ingredient, but is not limited thereto.
  • the present invention provides the use of the extract for use as a health food for inhibiting hair loss or promoting hair growth.
  • chlorophyll or pigment-removed plant extract of the present invention there is no particular limitation on the type of food to which the chlorophyll or pigment-removed plant extract of the present invention is added.
  • foods to which the above substances can be added include drinks, meat, sausages, bread, biscuits, rice cakes, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups,
  • beverages, alcoholic beverages and vitamin complexes, dairy products and dairy products, and all health functional foods in the usual sense are included.
  • the plant extract from which the chlorophyll or pigment of the present invention has been removed may be added to food as it is or may be used with other foods or food ingredients, and may be appropriately used according to a conventional method.
  • the mixing amount of the active ingredient may be appropriately determined depending on the purpose of use (for prevention or improvement).
  • the amount of the fermented red ginseng concentrate in the health functional food may be added in an amount of 0.1 to 90 parts by weight of the total food weight.
  • the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount above the above range.
  • the health food composition according to the present invention is a beverage composition
  • various flavoring agents or natural carbohydrates, etc., as in ordinary beverages are added as additional ingredients.
  • natural carbohydrates include monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, and the like; And polysaccharides, for example, common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • natural flavoring agents tacmatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.)
  • synthetic flavoring agents sacharin, aspartame, etc.
  • the proportion of the natural carbohydrate is generally about 1 to 20 g, preferably about 5 to 10 g per 100 g of the composition of the present invention.
  • the health food composition according to the present invention includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and heavy weight agents (cheese, chocolate, etc.), pectic acid and salts thereof, Alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like may be contained.
  • natural fruit juice and fruit juice beverages and may contain flesh for the production of vegetable beverages.
  • the present invention provides a method for inhibiting hair loss or promoting hair growth, comprising administering to an individual a pharmaceutically effective amount of the extract.
  • the present invention provides a method for preventing or improving hair loss, comprising administering to an individual a pharmaceutically effective amount of the extract.
  • the present invention provides a method for treating hair loss comprising administering to an individual a pharmaceutically effective amount of the extract.
  • the extract and hair loss are the same as the description of the composition for inhibiting hair loss or promoting hair growth, and the detailed description refers to the above.
  • chlorophyll and pigments are separated as an active ingredient including a chlorophyll and a pigment extract, camellia leaf extract, and wormwood extract as active ingredients, green tea leaf extract, cypress leaf extract and A mixed extract further comprising one or more extracts selected from the group consisting of Eoseongcho leaf extract may be usefully used for inhibiting hair loss and promoting hair growth.
  • the present inventors use plant extracts such as Hojanggeun extract, camellia leaf extract, wormwood extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract and various chlorophyll and pigment removal plant floral water.
  • plant extracts such as Hojanggeun extract, camellia leaf extract, wormwood extract, green tea leaf extract, cypress leaf extract and Eoseongcho leaf extract and various chlorophyll and pigment removal plant floral water.
  • the group consisting of a pigment-removed Hojanggeun extract prepared by the above method, a camellia leaf from which chlorophyll has been removed, and a wormwood extract as active ingredients, and a green tea leaf from which chlorophyll has been removed, a cypress leaf and Eoseongcho leaf extract Mist, shampoo and health food were prepared with a composition further containing one or more extracts selected from.
  • Green tea leaf extract was prepared by a general procedure of extracting alcohol [fermented alcohol, Daehan Alcohol Life Co., Ltd.] from plants with a solvent.
  • Camellia leaf extract was prepared by extracting and concentrating the camellia leaf purchased from WelPito Co., Ltd. in the same manner as in the method for preparing the Hojanggeun extract of Example ⁇ 1-1>.
  • the wormwood wormwood supplied from the Gokseong farmhouse (Godal-myeon, Godal-myeon, Gokseong-gun, Jeollanam-do) was extracted and concentrated in the same manner as in Example ⁇ 1-1> to prepare a wormwood extract.
  • Green tea leaves supplied from Hadong Green Tea Research Institute were extracted and concentrated in the same manner as in Example ⁇ 1-1>, to prepare a green tea leaf extract.
  • Cypress tree leaves supplied from the Jangheung Cypress Tree Complex were extracted and concentrated in the same manner as in the preparation method of the Hojanggeun extract of Example ⁇ 1-1> to prepare cypress leaves extract.
  • Eoseongcho leaves obtained from Gokseong farmhouse (Godal-myeon, Godal-myeon, Gokseong-gun, Jeollanam-do) were extracted and concentrated in the same manner as in Example ⁇ 1-1>, to prepare Eoseongcho leaf extract.
  • a liquid plant extract Floral Water
  • the pigments in the extract of chlorophyll roots were removed using the liquid plant extract for removing chlorophyll and pigments prepared in ⁇ Example 2>.
  • the extract from which the pigment was removed was completely frozen in a freezer and then freeze-dried with a freeze dryer (FDU-1200, EYELA) (FIG. 2).
  • a camellia leaf extract from which chlorophyll was removed was prepared in the same manner as in Example ⁇ 3-1> (FIG. 3).
  • a wormwood extract from which chlorophyll was removed was prepared in the same manner as in Example ⁇ 3-1> (FIG. 4).
  • a green tea leaf extract from which chlorophyll was removed was prepared in the same manner as in Example ⁇ 3-1> (FIG. 5).
  • Cypress tree leaf extract from which chlorophyll was removed was prepared in the same manner as in Example ⁇ 3-1> (FIG. 6).
  • Eoseongcho leaf extract from which chlorophyll was removed was prepared in the same manner as in ⁇ 3-1> in the above embodiment (FIG. 7).
  • chlorophyll and pigment removal were performed using the same method as in Example ⁇ 3-1>.
  • Green tea containing as an active ingredient, a pigment-removed Hojanggeun extract, a camellia leaf from which chlorophyll was removed, and a wormwood extract prepared through the process of ⁇ Example 1> to ⁇ Example 3>, and additionally removed chlorophyll Contains a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts, to prepare a mist for inhibiting hair loss or promoting hair growth without any chemical components, In order to increase preservation, the ratio of purified water and floral water extracted from cypress leaves was maintained at 1:1 to 19 (FIG. 8).
  • the concentration of each extract is 0.01 to 5 mg/ml.
  • a shampoo for inhibiting hair loss or promoting hair growth was prepared by mixing known shampoo ingredients in a composition for inhibiting hair loss or promoting hair growth containing one or more extracts selected from the group consisting of leaves, cypress leaves, and Eoseongcho leaf extracts (FIG. 9 ).
  • the concentration of each extract is 0.01 to 5 mg/ml.
  • a composition for inhibiting hair loss or promoting hair growth containing one or more extracts selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is added to 0.5 to 5.0 parts by weight of wheat flour, and bread, cakes, cookies, Crackers and noodles were prepared.
  • a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts was added to 10 parts by weight of ground beef to prepare ground beef for health promotion.
  • a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is added to 5 to 10 parts by weight of milk, and various such as butter and ice cream using the milk Dairy products were prepared.
  • Brown rice, barley, glutinous rice, and adlay were gelatinized by a known method, dried, and then roasted, and then prepared into a powder having a particle size of 60 mesh with a grinder.
  • Black soybeans, black sesame seeds, and perilla seeds were also steamed and dried by a known method, and then roasted, and then prepared into a powder having a particle size of 60 mesh with a grinder.
  • a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of leaves, cypress leaves and Eoseongcho leaf extracts is concentrated under reduced pressure in a vacuum concentrator, and the dried product obtained by drying with spraying and hot air dryer is subjected to particle size 60 It was pulverized with a mesh to obtain a dry powder.
  • Seeds perilla 7 parts by weight, black soybean 8 parts by weight, black sesame 7 parts by weight.
  • Extracts of the present invention (3 parts by weight),
  • Subsidiary materials such as liquid fructose 0.5%, oligosaccharide 2%, sugar 2%, salt 0.5%, water 75%, and the pigment of the present invention are removed, Camellia leaves and Mugwort extracts from which chlorophyll is removed as active ingredients Including, in addition, 0.5 g of a composition for inhibiting hair loss or promoting hair growth containing at least one extract selected from the group consisting of green tea leaves, cypress leaves, and Eoseongcho leaf extracts from which chlorophyll has been removed is homogeneously blended to perform instant sterilization. It was prepared by packaging it in a small container such as a glass bottle or a PET bottle.
  • Vegetable juice was prepared by adding 0.5 g of a composition for inhibiting hair loss or promoting hair growth containing one or more extracts to be added to 1,000 ml of tomato or carrot juice.
  • a fruit juice was prepared by adding 0.1 g of a composition for inhibiting hair loss or promoting hair growth containing one or more extracts to be added to 1,000 ml of apple or grape juice.
  • the present invention No. muscle (Polygonum cuspidatum) extract, camellia (Camellia japonica) leaf extract, and firefly wormwood (Artemisia annua) containing the extract as an active ingredient, and green tea (Camellia sinensis) leaves extract, cypress in accordance with the present invention ( Chamaecyparis obtusa ) leaf extract and Houttuynia cordata ( Houttuynia cordata )
  • the composition for inhibiting hair loss or promoting hair growth further containing one or more extracts selected from the group consisting of leaf extract is excellent in inhibiting hair loss or promoting hair growth, and at the same time has high safety and side effects Therefore, the extract can be used as a composition for inhibiting hair loss or promoting hair growth.

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Abstract

La présente invention concerne une composition qui est destinée à inhiber la perte des cheveux ou à favoriser la pousse des cheveux, laquelle composition comprend un extrait de Polygonum cuspidatum, un extrait de feuille de Camellia japonica et un extrait de Artemisia annua en tant que principes actifs, et contient en outre au moins un extrait choisi dans le groupe consistant en un extrait de feuille de Camellia sinensis, en un extrait de feuille de Chamaecyparis obtusa et en un extrait de feuille de Houttuynia cordata. La composition a un excellent effet lorsqu'il s'agit d'inhiber la perte des cheveux ou de favoriser la pousse des cheveux, est très sûre et n'a pas d'effets secondaires, et ainsi, l'extrait peut être utilisé efficacement comme composition pour inhiber la perte des cheveux ou favoriser la pousse des cheveux.
PCT/KR2020/005359 2019-04-23 2020-04-23 Composition pour inhiber la perte des cheveux ou favoriser la pousse des cheveux contenant un extrait de plante débarrassé de chlorophylle ou de pigment en tant que principe actif, et son procédé de production Ceased WO2020218840A1 (fr)

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KR1020190047113A KR102200906B1 (ko) 2019-04-23 2019-04-23 엽록소 또는 색소가 제거된 식물 추출물을 유효성분으로 함유하는 탈모 억제 또는 발모 촉진용 조성물 및 이의 제조방법
KR10-2019-0047113 2019-04-23

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KR20150104397A (ko) * 2014-03-05 2015-09-15 배용태 천연물로부터 엽록소를 분리하는 방법 및 엽록소를 제거하는 방법
KR20160008055A (ko) * 2014-07-11 2016-01-21 주식회사 엘지생활건강 동백잎 추출물을 유효성분으로 포함하는 체모 또는 피부 상태 개선용 조성물
KR101762796B1 (ko) * 2015-12-02 2017-07-31 한국 한의학 연구원 복합생약추출물의 발효물을 포함하는 탈모방지용 조성물
KR101802961B1 (ko) * 2016-02-26 2017-11-29 농업회사법인 우리엘바이오 주식회사 탈모 방지 조성물 및 그 제조방법

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KR20140115730A (ko) * 2013-03-22 2014-10-01 주식회사 미슬바이오텍 겨우살이 추출물 및 편백나무 추출물을 함유하는 탈모예방 및 발모촉진용 샴푸조성물
KR20150104397A (ko) * 2014-03-05 2015-09-15 배용태 천연물로부터 엽록소를 분리하는 방법 및 엽록소를 제거하는 방법
KR20160008055A (ko) * 2014-07-11 2016-01-21 주식회사 엘지생활건강 동백잎 추출물을 유효성분으로 포함하는 체모 또는 피부 상태 개선용 조성물
KR101762796B1 (ko) * 2015-12-02 2017-07-31 한국 한의학 연구원 복합생약추출물의 발효물을 포함하는 탈모방지용 조성물
KR101802961B1 (ko) * 2016-02-26 2017-11-29 농업회사법인 우리엘바이오 주식회사 탈모 방지 조성물 및 그 제조방법

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