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WO2020210320A8 - L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées - Google Patents

L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées Download PDF

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Publication number
WO2020210320A8
WO2020210320A8 PCT/US2020/027218 US2020027218W WO2020210320A8 WO 2020210320 A8 WO2020210320 A8 WO 2020210320A8 US 2020027218 W US2020027218 W US 2020027218W WO 2020210320 A8 WO2020210320 A8 WO 2020210320A8
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazolo
pyrimidin
dihydro
ones
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2020/027218
Other languages
English (en)
Other versions
WO2020210320A1 (fr
Inventor
Peter Qinhua HUANG
Kevin Duane BUNKER
Brant Clayton Boren
Aditya Krishnan UNNI
Sunny Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recurium IP Holdings LLC
Original Assignee
Recurium IP Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recurium IP Holdings LLC filed Critical Recurium IP Holdings LLC
Publication of WO2020210320A1 publication Critical patent/WO2020210320A1/fr
Publication of WO2020210320A8 publication Critical patent/WO2020210320A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés de formule (I). De tels composés, ainsi que des sels pharmaceutiquement acceptables et des compositions de ceux-ci, sont utiles pour traiter des maladies ou des affections, y compris des affections caractérisées par une prolifération cellulaire excessive, telles que le cancer du sein.
PCT/US2020/027218 2019-04-11 2020-04-08 L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées Ceased WO2020210320A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962832529P 2019-04-11 2019-04-11
US62/832,529 2019-04-11

Publications (2)

Publication Number Publication Date
WO2020210320A1 WO2020210320A1 (fr) 2020-10-15
WO2020210320A8 true WO2020210320A8 (fr) 2020-11-12

Family

ID=72750610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/027218 Ceased WO2020210320A1 (fr) 2019-04-11 2020-04-08 L,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées

Country Status (1)

Country Link
WO (1) WO2020210320A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3762385B1 (fr) 2018-03-09 2025-02-12 Recurium IP Holdings, LLC 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées
WO2021097139A1 (fr) 2019-11-15 2021-05-20 Recurium Ip Holdings, Llc Synthèse chirale d'un alcool tertiaire
WO2022221143A1 (fr) * 2021-04-12 2022-10-20 Recurium Ip Holdings, Llc Composé wee1 pour le traitement du carcinome séreux utérin
CN115403582A (zh) * 2021-05-28 2022-11-29 江苏天士力帝益药业有限公司 Wee1抑制剂及其用途
CN117751122A (zh) * 2021-08-11 2024-03-22 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物
WO2023107705A1 (fr) 2021-12-10 2023-06-15 Incyte Corporation Amines bicycliques utilisées comme inhibiteurs de cdk12
WO2025076311A1 (fr) * 2023-10-06 2025-04-10 Zeno Management, Inc. Formes solides d'un inhibiteur de wee1
CN119798282A (zh) * 2023-10-11 2025-04-11 智擎生技制药股份有限公司 基于稠合吡啶环的Myt1抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR060635A1 (es) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
EP2213673B1 (fr) * 2007-10-23 2013-06-05 Msd K.K. Dérivé de dihydropyrazolopyrimidinone substitué par pyridone
WO2019028008A1 (fr) * 2017-08-01 2019-02-07 Zeno Royalties & Milestones, LLC Analogues de 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one
WO2019074979A1 (fr) * 2017-10-09 2019-04-18 Girafpharma, Llc Composés hétérocycliques et leurs utilisations
EP3762385B1 (fr) * 2018-03-09 2025-02-12 Recurium IP Holdings, LLC 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones substituées

Also Published As

Publication number Publication date
WO2020210320A1 (fr) 2020-10-15

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