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WO2020200046A1 - Dispositif de test de thromboélastographie entièrement automatique et procédé de test - Google Patents

Dispositif de test de thromboélastographie entièrement automatique et procédé de test Download PDF

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Publication number
WO2020200046A1
WO2020200046A1 PCT/CN2020/081459 CN2020081459W WO2020200046A1 WO 2020200046 A1 WO2020200046 A1 WO 2020200046A1 CN 2020081459 W CN2020081459 W CN 2020081459W WO 2020200046 A1 WO2020200046 A1 WO 2020200046A1
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WO
WIPO (PCT)
Prior art keywords
detection
cup
blood
reagent
blood sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2020/081459
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English (en)
Chinese (zh)
Inventor
肖健
胡喜
陈杰年
王涛
姜峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemoassay Science and Technology Suzhou Co Ltd
Original Assignee
Hemoassay Science and Technology Suzhou Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemoassay Science and Technology Suzhou Co Ltd filed Critical Hemoassay Science and Technology Suzhou Co Ltd
Priority to EP20784727.8A priority Critical patent/EP3943935B1/fr
Publication of WO2020200046A1 publication Critical patent/WO2020200046A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
    • G01N11/14—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0496—Other details
    • G01N2035/0498—Drawers used as storage or dispensing means for vessels or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood

Definitions

  • the invention relates to a thrombus elasticity graph instrument, in particular to a fully automatic thrombus elasticity detection device and a detection method.
  • Thromboelastometer is a medical device used to detect whether blood can coagulate normally. It is generally necessary to test the patient's blood coagulation data through the thromboelastometer before performing the operation, and determine the patient's blood coagulation based on the detected blood coagulation data Whether the process is normal, the patient can be operated on only when the blood can clot normally. If the blood clotting process is abnormal, the patient's blood will not be able to clot normally during the operation, resulting in difficulty in hemostasis, which may endanger the patient's life.
  • the physical characteristics of blood clot detection are based on the following principle: a special static cylindrical blood cup that contains blood, rotates at a low speed at an angle of 4.75, and detects the movement of the blood sample through a detection rod immersed in the blood sample. After the fibrin platelet complex adheres the cup and the detection rod, the rotational force generated by the rotation of the cup can be transmitted to the detection rod in the blood sample.
  • the strength of the fibrin platelet complex can affect the amplitude of the movement of the detection rod, so that a strong blood clot can synchronize the movement of the needle with the movement of the cup. Therefore, the movement amplitude of the measuring rod is directly related to the strength of the formed blood clot.
  • the current thromboelastography instrument has a low degree of automation when detecting blood coagulation data. It needs to manually take the cup, fill the cup, add blood and reagents to the detection cup, and unload the cup, which requires expensive testing. The large amount of time of personnel causes the labor intensity of detecting blood coagulation data to be large and the detection efficiency is low.
  • the purpose of the present invention is to overcome the defects of the prior art and provide a fully automatic thrombus elasticity detection device and detection method.
  • a fully automatic thrombus elasticity detection device including a control device, and a detection cup carrying device connected to the control device, a detection drive device, multiple detection channels, a reagent storage device, Blood sample carrying device and liquid adding device, among which,
  • the detection cup carrying device carries a plurality of detection cups required for detection
  • the detection drive device includes a cup clamping mechanism and a detection drive mechanism connected to the cup clamping mechanism.
  • the cup clamping mechanism is driven by the detection drive mechanism to move to the detection cup carrying device, each detection channel, and the liquid adding device, at least Automatically take the cup, and cooperate with the process of removing the cup lid, adding reagents and blood samples, and blood testing;
  • the detection channel is used to automatically complete the blood detection process
  • the reagent storage device carries a plurality of reagent tubes, and each reagent tube contains a reagent;
  • the blood sample carrying device carries a plurality of blood sample test tubes, and each blood sample test tube contains a blood sample;
  • the liquid adding device is moved to the reagent storage device and the blood sample carrying device respectively, and the reagent and the blood sample are drawn respectively, and the drawn reagent and blood sample are respectively added to the detection cup.
  • the detection cup carrying device includes a detection cup tray and a first rotating disk, and the detection cup tray is mounted on the first rotating disk and carries a plurality of detection cups thereon.
  • the detection drive mechanism includes a first lifting drive mechanism, a rotation drive mechanism and a horizontal drive mechanism that are all connected to the cup clamping mechanism, and the cup clamping mechanism is driven in cooperation with the first lifting, rotating and horizontal driving mechanism. Move to the detection cup carrying device, each detection channel and the liquid adding device respectively.
  • the liquid adding device includes a liquid path system and a blood extraction driving mechanism connected to the liquid path system, a reagent extraction driving mechanism, and a rotation driving mechanism.
  • the blood extraction driving mechanism is connected with the blood suction member to drive the blood suction.
  • the test tube of the blood sample is extended into or out of the blood sample tube;
  • the reagent extraction driving mechanism is connected with the reagent suction member to drive the reagent aspiration member to extend into or out of the reagent tube;
  • the rotation driving mechanism and the blood extraction driving mechanism and the reagent extraction driving mechanism Both are connected to drive the two to move to the reagent storage device and the blood sample carrying device respectively.
  • the reagent storage device includes a housing, a conductive base installed in the housing, a conductive drawer for placing reagents, and an interlock for pressing and unlocking the conductive drawer and the conductive base.
  • the conductive drawer is movably installed on the conductive base.
  • the blood sample carrying device includes a second rotating disk and a blood sample tray installed on the second rotating disk, and a plurality of blood sample test tubes are carried on the blood sample tray.
  • the thrombus elasticity detection device further includes a waste collection device for collecting the used detection cup transferred by the detection driving device.
  • control device the detection cup carrying device, the detection driving device, multiple detection channels, the reagent storage device, the blood sample carrying device and the liquid adding device are all integrated in an outer cover.
  • the detection channel includes a cup lid device, a rotation mechanism connected with the detection cup, and a second lifting drive mechanism
  • the cup lid device is used to unload the cup lid from the detection rod into the detection cup
  • the second rotation mechanism is used to control the detection cup to make a rotation movement during detection
  • the second lifting drive mechanism is used to lift the detection cup to a set height.
  • the present invention also discloses another technical solution: a fully automatic thrombus elasticity detection method, including:
  • the cup clamping mechanism of the detection driving device is driven by the detection driving mechanism to first move to the detection cup carrier device to remove the detection cup, move the clamped detection cup to the detection channel for the cup cover, and then unload it
  • the detection cup with the lid is moved to the reagent storage device and the blood sample carrying device to add reagents and blood samples to the detection cup respectively. After the addition, the detection cup is moved and loaded on the detection channel;
  • the detection channel performs blood coagulation data detection
  • the detection driving device removes the detection cup from the detection channel
  • the cup clamping mechanism is driven by the detection driving mechanism to unload the detection cup to the waste collection device;
  • the beneficial effect of the present invention is that the present invention integrates the detection cup carrying device, the detection channel, the reagent storage device, the blood sample carrying device, etc., into one cabinet through the cooperation of two manipulators (detection drive device and liquid adding device), Realize full automation in the blood coagulation data detection process, improve detection efficiency and detection accuracy.
  • Figure 1 is a schematic view of the three-dimensional structure of the present invention after the cover is assembled
  • Figures 2 and 3 are two-angle three-dimensional schematic diagrams of the present invention with the outer cover removed;
  • FIG. 4 is a schematic diagram of the three-dimensional structure of the detection cup carrying device of the present invention.
  • Figure 5 is a schematic diagram of the exploded structure of Figure 4.
  • FIG. 6 is a schematic diagram of a top three-dimensional structure of the detection cup tray of the present invention.
  • Figure 7 is a schematic view of the top structure of the first rotating disk
  • Fig. 8 is a schematic view of the three-dimensional structure of the present invention (not including the rotation drive mechanism);
  • Figure 9 is a schematic diagram of the overall three-dimensional mechanism of the present invention except for the horizontal drive mechanism;
  • Fig. 10 is a schematic top view of the structure of Fig. 9;
  • Figure 11 is a schematic view of the three-dimensional structure of the detection channel (without heat preservation cover) of the present invention.
  • Figure 12 is an enlarged schematic view of the structure of the part circled in Figure 11;
  • FIG. 13 is another perspective three-dimensional structure diagram of the detection channel of the present invention.
  • Figure 14 is a three-dimensional schematic diagram of the reagent storage device of the present invention.
  • 15 is a schematic cross-sectional view of the reagent storage device of the present invention.
  • Figure 16 is a perspective schematic view of the conductive base of the present invention.
  • Figure 17 is a perspective view of the conductive drawer of the present invention.
  • Figure 18 is a schematic bottom view of Figure 17;
  • Figure 19 is a perspective schematic view of the refrigeration mechanism of the present invention.
  • FIG. 20 is a schematic front view of the blood sample carrying device of the present invention.
  • Figure 21 is a perspective schematic view of the rotating disk in Figure 20;
  • Figure 22 is a three-dimensional schematic diagram of the blood sample tray in Figure 20;
  • Figure 23 is a bottom schematic view of the tray body in Figure 22;
  • Figure 24 is a perspective schematic view of the transmission mechanism in Figure 20;
  • 25 is a block diagram of the structure of the fluid system of the present invention.
  • FIGS 26-28 are all structural block diagrams of different embodiments of the blood sample liquid path system of the present invention.
  • Figure 29 is a structural block diagram of the reagent liquid path system of the present invention.
  • Figure 30 is a schematic diagram of the three-dimensional structure of the liquid taking device of the present invention.
  • Fig. 31 is an enlarged schematic view of the structure of the part circled in Fig. 30.
  • Control device 100.
  • Test cup carrying device 201, test cup tray, 202, first rotating disk, 203, rotating disk driving device, 204, support frame, 205, carrying part, 206, first matching mounting part/groove, 207,
  • Detection driving device 301, cup clamping mechanism, 302, first lifting driving mechanism, 303, rotation driving mechanism, 304, horizontal driving mechanism, 305, clamping cup mounting seat, 306, second driving source, 308, clamping jaw Components, 309, reset elastic member, 310, clamp arm, 311, clamp arm, 312, second sensor, 313, mounting frame, 314, third drive source, 315, worm, 316, turbine, 317, screw, 318 , Lifting guide rod, 319, mounting plate, 320, fourth drive source, 321, rotating shaft, 322, fifth drive source, 323, drive screw, 324, slider;
  • Reagent storage device 501, housing, 502, conductive base, 503, conductive drawer, 504, refrigeration mechanism, 505, locking assembly, 506, rotating member, 507, first elastic member, 508, track groove, 509.
  • Lock pin 510, opening, 511, first guide groove, 512, limit groove, 513, second guide groove, 514, relief groove, 515, second elastic member, 516, guide member, 517, container Slot, 518, guide rail, 519, chute, 520, drawer body, 521, conductive carrier, 522, drawer panel, 523, refrigeration parts, 524, heat sink, 525, fan, 526, air inlet, 527, installation Turning plate, 528, liquid intake;
  • Blood sample carrying device 601, second rotating disk, 602, blood sample tray, 603, regular polygonal protrusions, 604, regular polygonal grooves, 605, tray body, 606, carrier, 607, second opening , 608, fixed seat, 609, blood sample tube carrier, 610, transmission mechanism, 611, transmission shaft, 612, second driving wheel, 613, second driven wheel, 614, motor, 615, barcode reader, 616, Plane light, 617, containing groove;
  • liquid path system 901, blood sample liquid path system, 902, reagent liquid path system, 903, blood suction part, 904, first suction control part, 905, suction part cleaning device, 906, first control valve , 907, air source, 908, water source, 909, one-way valve, 910, first diaphragm pump, 911, suction cleaning device for the outer wall, 912, suction cleaning tank, 913, second diaphragm pump, 914, sewage Collection device, 915, third diaphragm pump, 916, sewage tank, 917, sewage outlet, 918, reagent suction part, 919, second suction control part, 920, integrated rod, 921, communication port, 922, water source inlet ; 923, adapter;
  • Liquid taking device 931, blood extraction drive mechanism, 932, reagent extraction drive mechanism, 933, rotation drive mechanism, 934, first screw rod, 935, first sliding table, 936, first mounting plate, 937, A gear, 938, a second gear, 939, a second mounting plate, 940, a rotating bearing, 941, a first slide rail, 942, a first fixed boss, 943, a seventh drive source, 944, a second screw rod, 945, the second slide, 946, the second slide, 947, the second fixed boss, 948, the base, 949, the eighth drive source, 950, the rotating shaft, 951, the third motor, 952, liquid level sensor, 953. Waste collection, 954.
  • Tenth driving source 931, blood extraction drive mechanism, 932, reagent extraction drive mechanism, 933, rotation drive mechanism, 934, first screw rod, 935, first sliding table, 936, first mounting plate, 937, A gear, 938, a second gear, 939, a second mounting plate
  • the automatic thrombus elasticity detection device and detection method disclosed in the present invention realize the complete process of taking the cup, loading the cup, adding blood and reagents to the detection cup, detection, and unloading the cup after detection during the blood coagulation data detection process. automation.
  • a fully automatic thrombus elasticity detection device disclosed in the present invention includes a control device 100, a detection cup carrying device 200 connected to the control device 100, a detection drive device 300, and multiple detection devices.
  • these devices are all integrated in an outer cover 700.
  • the detection driving device 300 in the outer cover 700 cooperates with the liquid adding device, which completely replaces manual labor and completes the full automation of the blood coagulation data detection process.
  • the detection cup carrying device 200 is used to carry the detection cup required in the blood coagulation detection process. It specifically includes a detection cup tray 201, a first rotating disk 202, a rotating disk drive device 203, and a support frame 204. Among them, the detection cup tray 201 and the first rotating disk 202 are formed by using polygons with different sides and in a multiple relationship. The mating surfaces cooperate to realize that the detection cup tray 201 is quickly installed on the first rotating disk 202.
  • the detection cup tray 201 is integrally formed, and the whole is disc-shaped. It specifically includes a plurality of bearing portions 205 arranged in layers from top to bottom, and the outer diameter of these bearing portions 205 increases in the direction extending from the inner side to the outer side of the test cup tray 201, that is, the innermost and uppermost bearing portion
  • the outer diameter of 205 is the smallest, and the outermost and lowermost bearing portion 205 has the largest outer diameter. In this way, a step is formed between two adjacent bearing portions 205.
  • the layered structure of the detection cup tray 201 allows the tray to carry a larger number of detection cups 800 as required.
  • Each carrying portion 205 is provided with at least one circle of cup holes 212 for carrying the detection cup evenly distributed in the circumferential direction, and the shape of the cup hole 212 is set in accordance with the shape of the detection cup 800.
  • a total of 48 detection cups 800 can be loaded on the entire detection cup tray 201.
  • the detection cup tray 201 is installed on the first rotating disk 202, and the detection cup tray 201 and the first rotating disk 202 are installed in cooperation with the first matching installation portion 206 and the second matching installation portion 207 to realize the detection cup tray 201 Quickly install on the first rotating disk 202.
  • the first mating mounting portion 206 is formed on the lower surface of the detection cup tray 201, specifically located at the center of the lower surface, and is recessed upwardly from the lower surface of the detection cup tray 201, that is, a groove 208 is formed.
  • the inner surface of the groove 208 is formed as a first polygonal mating surface 209.
  • the first polygonal mating surface 209 is a regular polygon, specifically a regular octagon.
  • the first rotating disk 202 specifically includes the above-mentioned second matching mounting portion 207 and a limiting portion 210.
  • the second matching mounting portion 207 is formed by protruding upward from the upper surface of the limiting portion 210, and the second matching mounting portion 207 is inserted into the first Inside the mating mounting portion 206, after insertion, the outer side surface of the second mating mounting portion 207 is formed as a second polygonal mating surface 211, which fits with the first polygonal mating surface 209 of the first mating mounting portion 206, and
  • the second polygonal mating surface 211 is also a polygon, but the ratio of the number of sides to the number of sides of the first polygonal mating surface 209 is 1:n, where n is an integer greater than or equal to 2, that is, the ratio of the two mating surfaces The number of edges is different (not a 1:1 relationship) and multiple relationships.
  • the second polygonal matching surface 211 is a 24 regular polygon, that is, the ratio of the number of
  • first mating mounting portion 206 and the second mating mounting portion 207 are not limited to the above-mentioned groove and protrusion matching structure, and can also be replaced by the first mating mounting portion 206 being a protruding structure,
  • the mating mounting portion 207 is a groove structure, as long as the two can be matched with polygonal mating surfaces with different numbers of sides and arranged in a multiple relationship.
  • the rotating disk driving device 203 is connected to the first rotating disk 202 and is used to drive the first rotating disk 202 to rotate in the radial direction, so as to facilitate the sequential grabbing of the detection cup 800 by the detection driving device on the thromboelastometer.
  • the rotating disk drive device 203 specifically includes a first power source 213, a gear assembly 214, and a drive shaft.
  • the first power source 213 may be a motor
  • the gear assembly 214 is connected to the motor shaft 215 of the motor 213 and
  • the first rotating disk 202 is connected to drive the first rotating disk 202 to rotate in the radial direction.
  • the gear assembly 214 specifically includes a first master-slave wheel 216 and a first driven wheel 217.
  • the driving wheel 210 is fixedly mounted on the motor shaft 215.
  • the first driven wheel 217 meshes with the driving wheel 210 and is driven by the motor shaft 215. Turn for the rotation axis.
  • the motor shaft 215 is connected to the first driven wheel 217 and the first rotating disk 202, and is driven by the gear assembly 214 to drive the first rotating disk 202 to rotate in the radial direction.
  • the supporting frame 204 is used for supporting and installing the above-mentioned detection cup tray 201, the first rotating disk 202 and the rotating disk driving device 203.
  • the detection cup carrying device of the present invention further includes at least one sensor 218 installed on the support frame 204, and the first sensor 218 is arranged close to the detection cup tray 201 for detecting whether there is a detection cup on the detection cup tray 201.
  • the first sensor 218 is arranged close to the detection cup tray 201 for detecting whether there is a detection cup on the detection cup tray 201.
  • three first sensors 218 are provided on the support frame 204, which are located below the detection cup tray 201.
  • the three first sensors 218 correspond to the three detection cups on the detection cup tray 201.
  • the detection cup 800 is correspondingly provided with a first sensor 218.
  • the working principle of the detection cup carrying device is: manually or automatically fill the detection cup tray 201 with the detection cup 800, and quickly install the detection cup tray 201 full of the detection cup 800 on the first rotating disk 202.
  • the first rotating disk 202 is rotated under the drive of the rotating disk drive device 203 to transmit the detection cup 800 to the position to be grasped by the detection drive device (manipulator).
  • the detection drive device manipulator
  • the first sensor 218 senses the position on the rotating disk. Whether there is a detection cup 800 in the corresponding cup hole 212, if it is detected that there is no detection cup 800 on the detection cup tray 201, remove the detection cup tray 201 from the first rotating disk 202, refill the detection cup 800 and repeat the above process .
  • the detection drive device 300 is used to realize the automation of cup taking, cup loading, and cup unloading during the blood coagulation data detection process.
  • the detection driving device specifically includes a cup clamping mechanism 301, a first lifting driving mechanism 302, a rotation driving mechanism 303, and a horizontal driving mechanism 304.
  • the cup clamping mechanism 301 operates in the lifting, rotating and horizontal driving mechanisms 302, 303, and 304. Under the coordinated drive, the detection cup 800 is clamped and unloaded to the detection cup carrying device 200, the detection channel 400, and the liquid adding device.
  • the cup clamping mechanism 301 is used for clamping and unloading the detection cup 800.
  • it specifically includes a clamping cup mounting seat 305, a second driving source 306, a clamping jaw assembly 308, and a reset elastic member 309.
  • the two driving sources 306 are fixed on the clamping cup mounting seat 305 and move back and forth in the horizontal direction. Electromagnets can be used in implementation; the clamping jaw assembly 308 is mounted on the clamping cup mounting seat 305, which is under the action of the second driving source 306 Pinch or unload the detection cup 800.
  • the clamping jaw assembly 308 includes two clamping arms 310 and 311, one end of the two clamping arms 310 and 311 crosses, and the other end forms a clamping jaw.
  • the second driving source 306 is located close to the crossing end of the clamping jaw assembly 308, moves toward the direction close to the clamping jaw assembly 308, and abuts against the crossing end of the clamping jaw assembly 308 to drive the other end of the clamping jaw assembly 308 to open.
  • the reset elastic member 309 is arranged between the two clamping arms 310, 311 at the other end of the clamping jaw assembly 308, and is used to provide a reset elastic force to make the other ends of the two clamping arms 310, 311 retract. When implemented, the reset elastic member 309 can use springs.
  • the clamping cup mechanism 301 further includes a second sensor 312 installed on the clamping cup mounting seat 305 and arranged close to the clamping jaw assembly 308, for detecting the state of the clamping jaw assembly 308 gripping the detection cup 800, such as whether it is clamping or not. Live the detection cup 800.
  • a second sensor 312 installed on the clamping cup mounting seat 305 and arranged close to the clamping jaw assembly 308, for detecting the state of the clamping jaw assembly 308 gripping the detection cup 800, such as whether it is clamping or not. Live the detection cup 800.
  • the first lifting drive mechanism 302 is connected to the cup clamping mechanism 301 and is used to drive the cup clamping mechanism 301 to perform a lifting movement in a vertical direction.
  • the first lifting drive mechanism 302 specifically includes a mounting frame 313, an eighth drive source 949, a drive steering assembly, and a screw 317.
  • the eighth drive source 949 is fixedly installed on the mounting frame 313 and connected to the drive steering assembly.
  • the eight driving source 949 can also use a motor; the driving steering assembly is used to convert the axial rotation of the driving shaft of the eighth driving source 949 into radial rotation.
  • the driving steering assembly includes the driving of the eighth driving source 949.
  • the shaft-connected worm 315 and the worm gear 316 mating and meshing with the worm 315.
  • the worm gear 316 is sleeved on the screw 317 and is threadedly connected with the screw 317; the screw 317 is vertically installed on the mounting frame 313 and is driven by the turbine 316 Rotate in the horizontal direction; the screw 317 is connected to the clamping cup mounting seat 305 of the clamping cup mechanism 301, if a threaded connection is adopted, the screw 317 rotates while driving the clamping cup mounting seat 305 to move in the vertical direction.
  • the clamping jaw assembly 308 is synchronously driven to move up and down in the vertical direction, and the detection cup 800 on the clamping jaw assembly 308 is adjusted to a desired height.
  • the first lifting driving mechanism 302 further includes at least one lifting guide rod 318 vertically fixed on the mounting frame 313 for guiding, and the cup clamping mechanism 301 is connected to the lifting guide rod 318, specifically a cup clamping mechanism
  • the clamping cup mounting seat 305 of 301 passes through the lifting guide rod 318, and is driven by the screw 317 to perform a vertical lifting movement along the lifting guide rod 318.
  • the first lifting drive mechanism 302 and the rotation drive mechanism 303 are both integrated and mounted on the same mounting plate 319, wherein the first lifting drive mechanism 302 is fixed above the mounting plate 319, and the rotation drive mechanism 303 is fixed. Below the mounting plate 319.
  • the rotation drive mechanism 303 is connected to the cup clamping mechanism 301, specifically connected to the above-mentioned mounting plate 319, for driving the entire first lifting drive mechanism 302 through the mounting plate 319 to rotate in a second direction perpendicular to the above-mentioned first direction, here
  • the second direction is the horizontal direction
  • the cup clamping mechanism 301 connected to the first lifting drive mechanism 302 is synchronously driven to rotate in the horizontal direction, so that the cup clamping mechanism 301 rotates to a desired position.
  • the rotary drive mechanism 303 specifically includes an eighth drive source 949 and a rotating shaft 950 connected to the eighth drive source 949.
  • the eighth drive source 949 may also be a motor.
  • the rotating shaft 950 is connected to the first lifting drive.
  • the fixed connection of the mechanism 302 is specifically fixedly connected with the above-mentioned mounting plate 319. By driving the mounting plate 319 to rotate in the horizontal direction, the first lifting driving mechanism 302 fixed on the mounting plate 319 is driven, and then the first lifting driving mechanism 302 synchronously drives the cup clamping mechanism 301 connected to it to rotate in the horizontal direction.
  • the horizontal driving mechanism 304 is connected to the cup clamping mechanism 301, specifically fixedly connected to the above-mentioned mounting plate 319, for driving the cup clamping mechanism 301 to move horizontally in the second direction (ie, the horizontal direction).
  • the horizontal drive mechanism 304 includes a fifth drive source 322, a drive screw 323, and a sliding block 324.
  • the fifth drive source 322 may also be a motor to drive the screw 323 and the fifth
  • the driving source 322 is connected, the sliding block 324 is slidably mounted on the driving screw 323, and the upper end of the sliding block 324 is fixedly connected to the mounting plate 319.
  • the driving screw 323 is driven by the fifth driving source 322 to drive the sliding block 324 in the horizontal direction.
  • the slider 324 drives the rotary drive mechanism 303, the first lifting drive mechanism 302, and the cup clamping mechanism 301 integrated on the mounting plate 319 to slide in a horizontal direction, and drives the cup clamping mechanism 301 to the corresponding Workplace.
  • the detection channel 400 is used to realize the detection of blood coagulation data.
  • eight detection channels 400 are provided, which are respectively located on both sides of the detection driving device 300, and each side is provided with 4 detection channels.
  • Each detection channel 400 specifically includes a cup capping device, a rotating mechanism 409, and a lifting driving mechanism 413.
  • the cup capping device includes a ninth drive source 401, a drive rod 402, and a plate 403, wherein the ninth drive source 401 A motor can be used in implementation; the drive rod 402 is arranged vertically, one end (here, the upper end) is connected to the ninth drive source 401, and the other end is a free end, which rotates under the drive of the ninth drive source 401.
  • the driving rod 402 is a screw, that is, the outer surface is provided with an external thread.
  • the punching board 403 is sleeved on the driving rod 402, and it is arranged horizontally, that is, perpendicular to the driving rod 402.
  • the inner surface of the punching board 403 and the screw 402 is provided with internal threads (not shown) to realize the threaded connection between the two.
  • the punching plate 403 can move up and down relative to the screw 402.
  • the punching board 403 has a plate structure as a whole, and its other end away from the screw 402 is sleeved outside the detection rod 405, and a perforation 404 for the detection rod 405 to pass is formed on this end, but the detection rod 405 and The perforation 404 does not touch.
  • the cup capping device of this embodiment further includes at least one vertically arranged guide rod 406, and the punching plate 403 is also sleeved outside the guide rod 406, and is attached to the screw 402.
  • the lower guide rod 406 is driven to move up and down.
  • the other end of the punching board 403 is located above the cup cover 407 on the detection rod 405, and its plane is parallel or approximately parallel to the plane of the cup cover 407.
  • the bottom surface area of the other end of the punching plate 403 and the cup cover 407 is set to be greater than or equal to the area of the upper surface of the cup cover 407, so that the punching plate 403 and the cup cover 407 The cup cover 407 can be completely covered when in contact.
  • the driving rod 402 is driven by the ninth driving source 401 to drive the beating plate 403 to move toward the cup cover 407, so that the beating plate 403 is in contact with the cup cover 407 and the cup cover 407 is unloaded from the detection rod 405.
  • the cup beating action is more stable.
  • the detection rod 405 is also provided with a heat preservation cover 408 that wraps the upper end of the cup cover 407.
  • the heat preservation cover 408 surrounds the detection rod 405 and does not contact the detection rod 405 and is connected to the punching board 403. When the punching board 403 moves up and down, it is guided in the vertical direction, and at the same time, the contact area with the cup cover 407 is increased.
  • the rotation mechanism 409 is used to control the rotation of the detection cup 800 during detection.
  • the rotating mechanism 409 specifically includes a second drive source 410, a cam 411, and a rocker arm 412.
  • the second drive source 410 can also be implemented by a motor.
  • the cam 411 is connected to the second drive source 410. Driven by the 410 to rotate, one end of the rocker arm 412 is in contact with the cam 411, and the other end is connected to a cup holder 416 for holding the detection cup 800.
  • the rocker arm 412 drives the cup holder 416 connected to it to swing synchronously while the cam 411 rotates, so that the curve characteristic of the cam 411 can be used to accurately control the swing amplitude of the cup holder 416.
  • the lifting drive mechanism 413 is connected to the cup holder 416, and is used to drive the detection cup 800 in the cup holder 416 to move to a set detection height.
  • the structure can include a motor 414, a screw 415, a sliding table 417 and a bracket 418 during implementation.
  • the motor 414 is connected to the screw rod 415
  • the sliding table 417 is arranged on the screw rod 415
  • the rotary drive mechanism 8 is connected to the sliding table 417
  • the screw rod 415 drives the sliding table 417 to move up and down under the drive of the motor 414, thereby
  • the detection cup 800 is driven to move up and down, which will not be repeated here.
  • the principle and structure of blood coagulation data detection by the detection channel 400 can refer to the existing ones, which will not be repeated here.
  • the reagent storage device 500 is used for refrigerating reagents and/or blood.
  • the reagents are refrigerated for the liquid adding device to take the reagents for detection. It specifically includes a housing 501, a conductive base 502, a conductive drawer 503, an interlocking mechanism and a refrigerating mechanism 504.
  • the conduction base 502 is installed in the housing 501, which is used for heat transfer;
  • the conduction drawer 503 is located in the housing 501, and is movably installed on the conduction base 502, which is used to place reagents;
  • the mechanism 504 is installed in the housing 501 and is used for generating a cold source;
  • the interlocking mechanism is installed in the housing 501 and is used for pressing and unlocking the conductive drawer 503 and the conductive base 502.
  • the conductive drawer 503 and the conductive base 502 can be unlocked by pressing the conductive drawer 503 under the action of the interlocking mechanism, and then the conductive drawer 503 can be withdrawn to place the reagent to be refrigerated in the conductive drawer 503; reagent placement is complete Then, the conduction drawer 503 is assembled to the conduction base 502, and the conduction drawer 503 is locked with the conduction base 502 by pressing the conduction drawer 503 under the action of the interlocking mechanism, and the refrigeration mechanism 504 is connected to the conduction drawer through the conduction base 502 503 exchanges heat, and then cools the reagents in the conduction drawer 503.
  • the interlocking mechanism includes a locking assembly 505 mounted on the conductive base 502 and a track groove 508 mounted on the conductive drawer 503. With the cooperation of the locking assembly 505 and the track groove 508, the conductive drawer 503 and the conductive base 502 Press to lock or press to unlock.
  • the locking assembly 505 includes a rotating member 506 and a first elastic member 507.
  • One end of the rotating member 506 is pivotally connected to the conductive base 502 through a rotating shaft, and the opposite end is provided with a lock pin 509 extending into the track groove 508.
  • the rotating member 506 can drive the lock pin 509 to rotate around the rotating shaft, and the first elastic member 507 is connected with the rotating member 506 to drive the rotating member 506 to reset.
  • the first elastic member 507 is preferably a torsion spring.
  • the track groove 508 includes a first opening 510, a first guide groove 511, a limiting groove 512 and a second guide groove 513.
  • One end of the limiting groove 512 communicates with one end of the first guide groove 511, and the opposite end communicates with one end of the second guide groove 513.
  • the other end of the first guide groove 511 and the other end of the second guide groove 513 are both connected. It communicates with the first opening 510.
  • it is best that the depth of the first guide groove 511 is greater than the depth of the second guide groove 513, so that the lock pin 509 can first enter the first guide groove 511 when entering through the first opening 510.
  • pressing the conductive drawer 503 can make the conductive drawer 503 slide on the conductive base 502.
  • the lock pin 509 enters the first guide groove 511 through the first opening 510, and is in the first guide Under the action of the slot 511, it enters into the limiting slot 512.
  • the conductive drawer 503 and the conductive base 502 are locked; further, the conductive drawer 503 is continuously pressed, and the first elastic member Under the action of 507, the lock pin 509 moves from the limiting groove 512 to the second guide groove 513. Under the action of the second guide groove 513, the lock pin 509 finally moves out through the first opening 510, and the conductive drawer 503 and the conductive base 502 realizes unlocking.
  • the limiting groove 512 has a V or U shape as a whole, and the track groove 508 has a heart shape as a whole.
  • the conductive base 502 is also provided with a relief slot 514, and the locking assembly 505 is installed in the relief slot 514.
  • a relief slot 514 can also be provided on the conductive drawer 503 and set in the relief slot 514 Track groove 508. In this embodiment, it is best to provide a relief slot 514 on the conductive base 502 for assembling the rotating component.
  • the conductive base 502 is also provided with a second elastic member 515 for quickly ejecting the conductive drawer 503.
  • the conductive drawer 503 slides on the conductive base 502 to make the second elastic member 515 515 is continuously compressed.
  • the conductive drawer 503 stops compressing the second elastic member 515; when unlocking, press the conductive drawer 503, and the conductive drawer 503 further performs the second elastic member 515
  • the second elastic member 515 When the lock pin 509 moves from the lock pin 509 from the limiting groove 512 to the second guide groove 513, the second elastic member 515 generates a restoring force to make the conductive drawer 503 pop out, facilitating the conductive drawer 503 from the housing 501 Draw out within.
  • the conductive drawer 503 is also provided with a guide 516 for allowing the lock pin 509 to quickly enter the track groove 508.
  • the guide 516 is triangular in shape as a whole.
  • the conductive drawer 503 is provided with a plurality of containing grooves 517 for placing reagents.
  • the accommodating grooves 517 are preferably arranged in an arc shape. Of course, they can also be arranged according to actual needs.
  • both sides of the conductive drawer 503 are provided with guide rails 518, and the conductive base 502 is provided with a sliding groove 519 matched with the guide rail 518. Under the action of the guide rail 518 and the sliding groove 519, the conductive drawer 503 can be quickly assembled On the conductive base 502, the assembly accuracy is improved.
  • the conductive drawer 503 adopts a split structure, which includes a drawer body 520 and a conductive carrier 521 installed on the drawer body 520.
  • the conductive carrier 521 and the conductive base 502 are in contact with each other to achieve heat between the two. exchange.
  • a plurality of the containing grooves 517 are provided on the conductive carrier 521, and during implementation, the reagent is placed in the containing groove 517 to realize heat exchange with the conductive carrier 521.
  • a drawer panel 522 connected to the conductive drawer 503, and the conductive drawer panel is used to pull out or push into the conductive drawer 503.
  • the refrigeration mechanism 504 includes a refrigeration element 523, a heat dissipation element 524, and a fan 525.
  • the cooling element 523 is installed between the conductive base 502 and the heat dissipation element 524, and the heat dissipation element 524 is installed between the cooling element 523 and the fan 525.
  • the housing 501 is provided with a plurality of air inlets 526 at a position close to the heat sink 524. Under the action of the fan 525, the cooling air enters the housing 501 through the air inlet 526 and flows through the heat sink 524 to take away the heat sink 524. On the heat.
  • the refrigerating mechanism further includes a rotating plate 527 for installing the refrigerating member 523.
  • the cooling element 523 generates a cold source when it is energized, and exchanges heat with the reagent through the conductive base 502 and the conductive carrier 521, and the heat is transferred to the heat sink 524.
  • the fan 525 sucks in cooling air through the air inlet 526 to cool the air.
  • the heat on the heat sink 524 is taken away.
  • the end of the housing 501 is also provided with a number of liquid intake ports 528 matched with the reagent bottle. During implementation, the liquid intake needle passes through the liquid intake port 528 to enter the reagent to absorb the reagent.
  • the blood sample carrying device 600 is used to contain blood for the liquid adding device to take a blood sample for testing. It specifically includes a second rotating disk 601 and a blood sample tray 602 mounted on the second rotating disk 601. The blood sample tray 602 is used to carry blood sample test tubes containing blood samples.
  • the second rotating disk 601 is provided with a regular polygon protrusion 603, and the blood sample tray 602 is provided with a regular polygon matching the regular polygon protrusion 603
  • the groove portion 604 the ratio of the number of sides of the regular polygon convex portion 603 to the regular polygon groove portion 604 is at least 1:4, or the second rotating disk 601 is provided with a regular polygon groove portion 604, and the blood sample tray 602
  • the blood sample tray 602 includes a tray body 605 and a plurality of carriers 606 mounted on the tray body 605, wherein a regular polygonal convex portion 603 or a regular polygonal groove portion 604 is provided on the tray body 605, and the carrier 606 Used to place blood sample tubes containing blood samples.
  • the plurality of carriers 606 are distributed in a circle with the center of the tray body 605 as the center and are enclosed in at least one circle. In specific implementation, it is best that a plurality of carriers 606 are enclosed in at least two circles, and the carrier 606 located in the inner circle and the carrier 606 located in the outer circle are arranged in a staggered manner, so as to obtain a blood sample on the carrier 606 in the inner circle.
  • the barcode of the test tube is arranged in a staggered manner, so as to obtain a blood sample on the carrier 606 in the inner circle.
  • the carrier 606 is provided with a second opening 607.
  • the barcode on the blood sample tube is located at the second opening 607, so as to facilitate obtaining the barcode on the blood sample tube.
  • the carrier 606 includes a round tube-shaped fixing seat 608 and a blood sample test tube bearing seat 609 inserted on the fixing seat 608, the fixing seat 608 is installed on the tray body 605, and the second opening 607 is provided on the blood sample test tube bearing seat 609 On the side circumference.
  • the carrier 606 adopts a split design to facilitate the installation of the blood sample test tube.
  • the carrier 606 can also adopt an integrated design.
  • the tray body 605 is provided with an accommodation groove 617 for accommodating the fixing seat 608.
  • the plurality of fixing seats 608 are distributed in a circle with the center of the tray body 605 as the center and are enclosed in at least one circle.
  • the blood sample carrying device 600 also includes a transmission mechanism 610 that drives the second rotating disc 601 to rotate, which includes a transmission shaft 611, a second driving wheel 612, a second driven wheel 613, and a motor 614.
  • a transmission shaft 611 One end of the transmission shaft 611 is provided with a second A second driven wheel 612 is installed at the opposite end of the rotating disc 601, and the second driving wheel 612 is connected to the rotating shaft of the motor 614 and is meshed with the second driven wheel 612.
  • the motor 614 drives the second driving wheel 612 to rotate, the second driving wheel 612 then drives the second driven wheel 612 to rotate, and the second driven wheel 612 drives the second rotating disk 601 to rotate through the transmission shaft 611.
  • the blood sample carrying device further includes a barcode reader 615, which is arranged near the blood sample tray 602, and is used to read the barcode on the blood sample test tube.
  • the light emitted by the barcode reader 615 is a plane light 616. Since the carrier 606 on the outer ring and the carrier 606 on the inner ring are misaligned, the plane light 616 emitted by the barcode reader 615 can pass through the outside. The gap between the circle carriers 606 enters the inner circle, and the barcode reader 615 can read the barcode of the blood sample tube on the inner circle carrier 606.
  • the liquid adding device is used to automatically add reagents and blood samples to the detection cup.
  • the fluid path system 900 specifically includes an independent blood sample fluid path system 901 and a reagent fluid path system 902.
  • the blood sample fluid path system 901 is used to realize the automatic addition process of blood in blood coagulation data detection
  • the reagent fluid path system 902 is used for Realize the actual automatic adding process in blood coagulation data detection.
  • the blood sample fluid path system 901 includes a blood suction component 903, a first suction control component 904, and a suction component cleaning device 905.
  • the blood suction component 903 is used to suck blood, and the whole is A hollow suction needle shape, the lower end of which goes deep into the blood sample tube when sucking blood.
  • the first suction control part 904 is in communication with the blood suction part 903, and is specifically connected to the upper end of the blood suction part 903 through a hose.
  • the first suction control part 904 can be a plunger pump, and its working principle is: When the first suction control part 904 is working, it controls the formation of negative pressure in the blood suction part 903, and sucks the blood in the blood sample tube into the blood suction part 903. When closed, controls the blood suction part 903 to draw The sucked blood is released into the detection cup 800.
  • the suction piece cleaning device 905 is connected to the blood suction piece 903, and is used for thoroughly cleaning the inner wall of the blood suction piece 903 after the blood suction piece 903 releases blood into the detection cup.
  • the suction element cleaning device 905 includes a first control valve 906, the first control valve 906 communicates with the blood suction element 903 through the first suction control element 904, and the first control valve 906 also Connect with air and water sources.
  • the first control valve 906 can be a control valve with at least three ports, such as a three-way valve, of course, it can also be a four-way valve or a five-way valve.
  • the water source 908 can be clean water, which is stored in a water tank, that is, the three-way valve is connected to the water tank; the air source 907 can be air; in addition, the first liquid path valve 906 and the water source 908 can also be It is connected by an adapter 923.
  • the three-way valve 906 controls the interface connected to the water tank 908 to be in a connected state, and the interface connected to the air source 907 is in a closed state. Then, under the control of the first suction control member 904, suction is taken from the water tank 908 The water source enters the blood suction part 903 through each connecting hose to clean the inner wall of the blood suction part 903. After cleaning, in order to remove the remaining cleaning liquid on the inner wall of the blood suction part 903, the three-way valve 906 controls The interface connected to the water tank 908 is in a closed state, and the interface connected to the air source 907 is in a connected state.
  • the air source 907 is sucked through various connecting hoses for blood suction In the part 903, the cleaning liquid remaining on the inner wall of the blood suction part 903 is blown off.
  • the blood suction member 903 is deeply cleaned and blown dry, so that it can suck other types of blood samples and avoid cross-contamination between different blood samples.
  • the first suction control member 904 and the first control valve 906 A one-way valve 909 can also be added in between, that is, the water source 908 and the air source 907 can only be input into the blood suction part 903 in one direction, and the reverse direction is not connected.
  • the one-way valve 909 is closed when the first suction control part 904 is opened to control the blood suction part 903 to suck blood, and is opened when the suction part cleaning device 905 is working.
  • a first diaphragm pump 910 is connected between the one-way valve 909 and the first control valve 906 to cooperate with the first suction control member 904 to realize the suction control of the water source 908 and the air source 907.
  • the blood sample liquid path system 901 of the embodiment of the present invention further includes a suction piece outer wall cleaning device 911, which specifically includes suction A cleaning tank 912 and a second diaphragm pump 913, wherein the blood suction part 903 extends into the suction cleaning tank 912, and the suction cleaning tank 912 passes through the second diaphragm pump 913 and the above-mentioned water source (ie, the water tank 908) Connected, that is, the second diaphragm pump 913 connects the suction unit cleaning tank 912 and the water tank 908, and is used to control the suction of the water in the water tank 908 into the suction unit cleaning tank 912 and to clean the blood in the suction unit cleaning tank 912 The outer wall of the suction member 903 is cleaned.
  • a suction piece outer wall cleaning device 911 specifically includes suction A cleaning tank 912 and a second diaphragm pump 913, wherein the blood suction part 903 extends into the suction cleaning tank 912, and the suction
  • a water source inlet 922 is opened on the side wall of the suction cleaning pool 912 close to the top of itself, and the water source inlet 922 is in communication with the second diaphragm pump 913.
  • the embodiment of the present invention sets the height of the water source inlet 922 in the suction member cleaning pool 912 to be higher than that The height of the blood sample on the outer wall of the blood suction member 903 in the suction member cleaning pool 912, that is, above the blood sample on the outer wall of the blood suction member 903, so as to ensure that the water entering the blood suction member 903 can completely cover and wash the blood.
  • the blood sample on the outer wall of the aspirating member 903 makes the blood sample on the outer wall of the blood aspirating member 903 clean thoroughly.
  • the blood sample liquid path system of the embodiment of the present invention may further include a sewage collection device 914, which is connected to the suction member cleaning tank 912, and is used to connect the suction member cleaning device 905 and the outer wall of the suction member.
  • the sewage generated after cleaning by the cleaning device 911 is collected and discharged.
  • the sewage collection device 914 includes a third diaphragm pump 915 and a sewage tank 916 connected to the third diaphragm pump 915, wherein a sewage outlet 917 is provided on the suction cleaning tank 912, which is specifically arranged At its bottom; the third diaphragm pump 915 communicates with the sewage outlet 917 and the sewage bucket 916, and is used to control the discharge and collection of the cleaning sewage generated in the suction cleaning pool 912 into the sewage bucket 916.
  • the reagent liquid path system 902 specifically includes at least one reagent suction component 918 and a second suction control component 919 connected to the reagent suction component 918, wherein the reagent suction component 918 is used for suction and detection.
  • the reagent suction part 918 is generally set to be multiple when implemented, and each reagent suction part 918 correspondingly sucks one kind of reagent.
  • the number of reagent suction parts 918 is not limited, and it can be set according to the needs of the reagent.
  • Each reagent suction member 918 is also in the shape of a hollow suction needle as a whole, and its lower end penetrates into the reagent tube (not shown) when the reagent is sucked.
  • the seven reagent suction members 918 are all connected to an integrated rod 92020, and a communication port 921 is provided on the integrated rod 92020 at a position corresponding to each reagent suction member 918.
  • the second suction control member 919 is selectively connected to the communication port 921 on the integrated rod 92020 as required, so as to realize the connection of the reagent suction member 918 corresponding to the communication port 921. Because each reagent suction member 918 correspondingly absorbs a detection reagent, there is no cross-contamination between each other, so the reagent liquid path system here may not be provided with a corresponding cleaning device.
  • the liquid taking device 930 realizes the driving automation of the blood sample and reagent adding process through the cooperation of the three designed driving mechanisms (the blood drawing driving mechanism 931, the reagent drawing driving mechanism 932, and the rotation driving mechanism 933).
  • a liquid extraction device 930 disclosed in an embodiment of the present invention includes a blood extraction drive mechanism 931, a reagent extraction drive mechanism 932, and a rotation drive mechanism 933, wherein the blood extraction drive mechanism 931 is the same as the above
  • the blood suction member 903 is connected to drive the blood suction member 903 to extend into or out of the blood sample test tube;
  • the reagent extraction driving mechanism 932 is connected to the reagent suction member 918 to drive the reagent suction member 918 to extend into or out of the reagent tube (not shown) Show);
  • the rotation drive mechanism 933 is connected with the blood extraction drive mechanism 931 and the reagent extraction drive mechanism 932, cooperates with these two mechanisms 1, 2 to drive the rotation of the two in the first direction, and move to the corresponding blood sample carrier At the device 600 and the reagent storage device 500.
  • the first direction in this embodiment is the horizontal direction.
  • the blood pumping driving mechanism 931 includes a sixth driving source 934, a first gear assembly, a first screw 934, and a first sliding table 935, wherein the sixth driving source 934 is fixed to a first mounting plate that is vertically arranged
  • the upper part 936 is specifically fixed to the lower end of the first mounting plate 936.
  • the sixth driving source 934 can adopt the first motor 937, and the driving shaft of the first motor 937 passes through the first mounting plate 936 horizontally.
  • the first gear assembly includes a first gear 937 and a second gear 938, wherein the first gear 937 is fixed to the top end of the drive shaft of the first motor 937 (that is, the end that passes through the first mounting plate 936), which is at the first
  • the motor 937 drives the shaft to rotate axially.
  • the second gear 938 is sleeved on the first screw 934 and meshes vertically with the first gear 937, that is, the second gear 938 rotates in a radial direction perpendicular to the axial direction while the first gear 937 rotates, that is, 90 ° of steering.
  • the first screw rod 934 is vertically arranged, that is, parallel or approximately parallel to the plane where the first mounting plate 936 is located. In this embodiment, it is threadedly connected with the second gear 938, which can be driven by the rotation of the second gear 938 The second gear 938 rotates in the opposite radial direction.
  • the upper and lower ends of the first screw rod 934 are respectively rotatably connected to a second mounting plate 939, and the second mounting plate 939 and the first mounting plate 936 can be integrally formed or separately provided.
  • the rotational connection between the two ends of the first screw rod 934 and the second mounting plate 939 can be achieved through the rotating bearing 940.
  • the first sliding table 935 is slidably connected to the first screw 934, and moves up and down along with the rotation of the first screw 934. Specifically, in this embodiment, the first sliding table 935 is located between the two second mounting plates 939 and is arranged at the upper end of the first screw 934. Preferably, the first sliding table 935 is also guided by the first sliding rail 941 to move in the vertical direction, and the inner side surface of the first sliding table 935 abutting the first sliding rail 941 is provided with the first sliding rail.
  • the first sliding groove (not shown in the figure) that is matched with 941, and in this embodiment, the first sliding rail 941 is vertically arranged on the first mounting plate 936.
  • the outer side surface of the first sliding table 935 protrudes outward to form a first fixing boss 942, and the blood suction member 903 vertically penetrates the first fixing boss 942 and is fixed. In the first fixed boss 942.
  • the first sliding table 935 is driven by the first screw 934 to drive the blood suction member 903 to extend into or out of the blood sample test tube.
  • the first sliding table 935 is connected to a blood suction component 903, and the blood suction component 903 is used to suck blood samples of different blood types.
  • the reagent extraction drive mechanism 932 is similar in structure to the blood extraction drive mechanism 931. In this embodiment, it specifically includes a seventh drive source 943, a second gear assembly, a second screw rod 944, and a second sliding table 945.
  • the seventh drive The source 943 is also fixed on the above-mentioned first mounting plate 936, specifically fixed on the lower end of the first mounting plate 936, and arranged side by side with the sixth driving source 934.
  • the seventh driving source 943 can also be driven by a motor.
  • the shaft passes through the first mounting plate 936 horizontally.
  • the second gear assembly has the same structure as the first gear assembly.
  • the second gear assembly also includes a first gear 937 and a second gear 938.
  • the first gear 937 is fixed to the top end of the drive shaft of the second motor 943 (that is, passes through the first mounting plate 936). It is driven by the drive shaft of the second motor 943 to axially rotate.
  • the second gear 938 is sleeved on the second screw rod 944 and meshes perpendicularly with the first gear 937, that is, the second gear 938 rotates in a radial direction perpendicular to the axial direction while the first gear 937 rotates, that is, 90 ° of steering.
  • the present invention is not limited to the gear assembly structure here, and other transmission structures between the driving source and the screw rod are applicable to the present invention.
  • the second screw rod 944 is vertically arranged, that is, parallel or approximately parallel to the plane where the first mounting plate 936 is located. In this embodiment, it is threadedly connected with the second gear 938, and it can be driven by the rotation of the second gear 938.
  • the second gear 938 rotates in the opposite radial direction.
  • the upper and lower ends of the second screw rod 944 are also rotatably connected to the second mounting plate 939.
  • the rotational connection between the two ends of the second screw rod 944 and the second mounting plate 939 can also be achieved through the rotating bearing 940.
  • the second sliding table 945 is slidably connected to the second screw rod 944, and moves up and down with the rotation of the second screw rod 944. Specifically, in this embodiment, the second sliding table 945 is located between the above two second mounting plates 939 and is arranged at the upper end of the second screw rod 944. Preferably, the second sliding table 945 is also guided by the second sliding rail 946 to move in the vertical direction. The inner surface of the second sliding table 945 abutting the second sliding rail 946 is provided with the second sliding rail. The second sliding groove (not shown in the figure) that is matched with 946, and in this embodiment, the second sliding rail 946 is vertically arranged on the first mounting plate 936.
  • the outer side surface of the second sliding table 945 protrudes outward to form a second fixing boss 947, and the reagent suction member 918 vertically penetrates the second fixing boss 947 and is fixed. In the second fixed boss 947.
  • the second sliding table 945 is driven by the second screw rod 944 to drive the reagent suction member 918 to extend into or out of the reagent tube.
  • the second sliding table 945 is connected to a plurality of reagent suction members 918, preferably seven, and each reagent suction member 918 correspondingly suctions a reagent.
  • a plurality of reagent suction members 918 may all be connected to an integrated rod 920, and a communication port 921 is provided on the integrated rod 920 at a position corresponding to each reagent suction member 918.
  • the first motor 937, the second motor 943, the first mounting plate 936 and the lower second mounting plate 939 are all integrated and fixed on a base 948.
  • the rotation driving mechanism 933 is connected to the base 948 to realize the connection with the entire blood extraction driving mechanism 931 and the reagent extraction driving mechanism 932, and is used to drive the two mechanisms 931, 932 to rotate in the horizontal direction, so that the two mechanisms 931, 932 moves to the corresponding blood sample tube and reagent tube respectively, and cooperates with these two mechanisms 931 and 932 to complete the automated driving of the blood adding and reagent adding process.
  • the rotating drive mechanism 933 specifically includes an eighth drive source 949 and a rotating shaft 950.
  • the eighth drive source 949 can adopt a third motor 951.
  • the third motor 951 is connected to the rotating shaft 950 to drive the rotating shaft 950 to rotate; It is also connected to the base 948 described above, and the base 948 is driven to rotate in the horizontal direction, thereby synchronously driving the blood extraction driving mechanism 931 and the reagent extraction driving mechanism 932 to move in the horizontal direction.
  • the first mounting plate 936 is also provided with a liquid level sensor 952 for detecting the liquid level in the blood suction member 903 and the reagent suction member 918, so that the blood suction member 903 and the reagent suction member 918 are respectively drawn to Set the level of blood samples and reagents.
  • a liquid level sensor 952 for detecting the liquid level in the blood suction member 903 and the reagent suction member 918, so that the blood suction member 903 and the reagent suction member 918 are respectively drawn to Set the level of blood samples and reagents.
  • the automatic thrombus elasticity detection method disclosed in the present invention includes:
  • the cup clamping mechanism of the detection driving device is driven by the detection driving mechanism to first move to the detection cup carrier device to remove the detection cup, move the clamped detection cup to the detection channel for the cup cover, and then unload it
  • the detection cup of the cup lid is moved to the reagent storage device and the blood sample carrying device to add reagents and blood samples to the detection cup respectively. After the addition, the detection cup is moved and loaded on the detection channel.
  • the detection channel performs blood coagulation data detection.
  • the detection drive device removes the detection cup from the detection channel.
  • the cup clamping mechanism is driven by the detection drive mechanism to unload the detection cup to the waste collection device.

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Abstract

L'invention concerne un dispositif de test de thromboélastographie entièrement automatique et un procédé de test. Le dispositif de test de thromboélastographie entièrement automatique comprend un dispositif de commande (100), et un dispositif de support de coupelle de test (200), un dispositif d'entraînement de test (300), de multiples canaux de test (400), un dispositif de stockage de réactif (500), un dispositif de support d'échantillon de sang (600), et un dispositif d'ajout de liquide qui sont tous connectés au dispositif de commande (100). Le dispositif d'entraînement de test (300) comprend un mécanisme de maintien de coupelle (301) et un mécanisme d'entraînement de test relié au mécanisme de maintien de coupelle (301). Le mécanisme de maintien de coupelle (301) est entraîné par le mécanisme d'entraînement de test pour se déplacer séparément vers les positions du dispositif de support de coupelle de test (200), les canaux de test individuels (400), ou le dispositif d'ajout de liquide, et effectue au moins automatiquement une prise de coupelle, et coopère avec des procédures de retrait de couvercle de coupelle, d'ajout de réactif et d'échantillonnage de sang et d'analyse de sang. L'invention comprend deux bras robotiques, et intègre divers dispositifs à l'intérieur d'une enceinte, ce qui permet d'obtenir un processus de test de données de coagulation sanguine entièrement automatisé, et d'améliorer l'efficacité de test et la précision de test.
PCT/CN2020/081459 2019-03-29 2020-03-26 Dispositif de test de thromboélastographie entièrement automatique et procédé de test Ceased WO2020200046A1 (fr)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112782415A (zh) * 2020-12-24 2021-05-11 星童医疗技术(苏州)有限公司 测试前处理装置、医用设备及检测方法
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CN113985043A (zh) * 2021-10-27 2022-01-28 赫菲斯科技(深圳)有限公司 一种血栓弹力图仪
CN114192030A (zh) * 2022-02-18 2022-03-18 中国人民解放军总医院第八医学中心 一种血液科采血摇匀装置
CN114894699A (zh) * 2022-04-13 2022-08-12 高特威尔科学仪器（青岛）有限公司 腐蚀高通量测试试验机
CN115128291A (zh) * 2022-08-26 2022-09-30 普迈德（北京）科技有限公司 一种适于凝血检测装置的机械臂机构及凝血检测装置
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CN116165051A (zh) * 2023-02-21 2023-05-26 济宁九德半导体科技有限公司 一种自动加酸仪
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109946444B (zh) * 2019-03-29 2025-02-25 美国血液技术公司 一种全自动的血栓弹力检测装置及检测方法
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WO2023070349A1 (fr) * 2021-10-27 2023-05-04 阳普医疗科技股份有限公司 Instrument de thromboélastogramme
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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014031253A1 (fr) * 2012-08-22 2014-02-27 Biomedica Usa, Llc Dispositif et procédé de réalisation de dosages sanguins par thromboélastographie par détection magnétique
CN104614539A (zh) * 2013-11-05 2015-05-13 北京乐普医疗科技有限责任公司 一种血栓弹力图仪
CN106370829A (zh) * 2016-08-30 2017-02-01 诺泰科生物科技（苏州）有限公司 一种血栓弹力仪及盛血杯装卸方法
WO2017121288A1 (fr) * 2016-01-11 2017-07-20 广州阳普医疗科技股份有限公司 Appareil de mesure de coagulation du sang
CN107014990A (zh) * 2017-05-15 2017-08-04 深圳麦科田生物医疗技术有限公司 全自动血栓弹力测量装置
CN107505456A (zh) * 2017-09-29 2017-12-22 重庆南方数控设备有限责任公司 全自动检测式血栓弹力图仪及使用方法
WO2018137766A1 (fr) * 2017-01-26 2018-08-02 Dynabyte Informationssysteme Gmbh Dispositifs et procédés de mesure de changements viscoélastiques d'un échantillon
CN108562753A (zh) * 2018-04-12 2018-09-21 赫安仕科技（苏州）有限公司 一种盛血杯杯盖装卸装置及装卸方法
CN109946444A (zh) * 2019-03-29 2019-06-28 赫安仕科技（苏州）有限公司 一种全自动的血栓弹力检测装置及检测方法
CN210071834U (zh) * 2019-03-29 2020-02-14 赫安仕科技（苏州）有限公司 一种全自动的血栓弹力检测装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202182886U (zh) * 2011-08-24 2012-04-04 山东兰桥医学科技有限公司 多通道分血装置
CN104458503B (zh) * 2014-12-12 2016-11-30 广州阳普医疗科技股份有限公司 一种凝血检测仪器
CN106124786B (zh) * 2016-08-10 2018-05-08 浙江盛域医疗技术有限公司 一种血栓半自动弹力图仪
CN206935451U (zh) * 2017-06-27 2018-01-30 莫纳（苏州）生物科技有限公司 一种有锁止功能的试管架
CN109342753B (zh) * 2018-09-27 2024-05-07 中国科学院苏州生物医学工程技术研究所 样本传送装置

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014031253A1 (fr) * 2012-08-22 2014-02-27 Biomedica Usa, Llc Dispositif et procédé de réalisation de dosages sanguins par thromboélastographie par détection magnétique
CN104614539A (zh) * 2013-11-05 2015-05-13 北京乐普医疗科技有限责任公司 一种血栓弹力图仪
WO2017121288A1 (fr) * 2016-01-11 2017-07-20 广州阳普医疗科技股份有限公司 Appareil de mesure de coagulation du sang
CN106370829A (zh) * 2016-08-30 2017-02-01 诺泰科生物科技（苏州）有限公司 一种血栓弹力仪及盛血杯装卸方法
WO2018137766A1 (fr) * 2017-01-26 2018-08-02 Dynabyte Informationssysteme Gmbh Dispositifs et procédés de mesure de changements viscoélastiques d'un échantillon
CN107014990A (zh) * 2017-05-15 2017-08-04 深圳麦科田生物医疗技术有限公司 全自动血栓弹力测量装置
CN107505456A (zh) * 2017-09-29 2017-12-22 重庆南方数控设备有限责任公司 全自动检测式血栓弹力图仪及使用方法
CN108562753A (zh) * 2018-04-12 2018-09-21 赫安仕科技（苏州）有限公司 一种盛血杯杯盖装卸装置及装卸方法
CN109946444A (zh) * 2019-03-29 2019-06-28 赫安仕科技（苏州）有限公司 一种全自动的血栓弹力检测装置及检测方法
CN210071834U (zh) * 2019-03-29 2020-02-14 赫安仕科技（苏州）有限公司 一种全自动的血栓弹力检测装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3943935A4 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112782415A (zh) * 2020-12-24 2021-05-11 星童医疗技术(苏州)有限公司 测试前处理装置、医用设备及检测方法
CN113985043A (zh) * 2021-10-27 2022-01-28 赫菲斯科技(深圳)有限公司 一种血栓弹力图仪
CN113791235A (zh) * 2021-11-18 2021-12-14 深圳优迪生物技术有限公司 全自动血栓弹力图仪及血样测试方法
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CN114894699A (zh) * 2022-04-13 2022-08-12 高特威尔科学仪器（青岛）有限公司 腐蚀高通量测试试验机
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CN115283042B (zh) * 2022-06-20 2023-12-29 宜兴市拜奥精核生物科技有限公司 一种基因检测试剂盒夹持工艺及防污染夹持设备
CN115128291A (zh) * 2022-08-26 2022-09-30 普迈德（北京）科技有限公司 一种适于凝血检测装置的机械臂机构及凝血检测装置
CN116165051A (zh) * 2023-02-21 2023-05-26 济宁九德半导体科技有限公司 一种自动加酸仪
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