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WO2020137694A1 - Capsule - Google Patents

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Publication number
WO2020137694A1
WO2020137694A1 PCT/JP2019/049391 JP2019049391W WO2020137694A1 WO 2020137694 A1 WO2020137694 A1 WO 2020137694A1 JP 2019049391 W JP2019049391 W JP 2019049391W WO 2020137694 A1 WO2020137694 A1 WO 2020137694A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
gelatin
mass
content
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2019/049391
Other languages
English (en)
Japanese (ja)
Inventor
一宏 鳥井
涼太 要田
忠杜 渋谷
美優 岡野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Kobayashi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co Ltd filed Critical Kobayashi Pharmaceutical Co Ltd
Publication of WO2020137694A1 publication Critical patent/WO2020137694A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Definitions

  • the present invention relates to capsules.
  • Gelatin is not toxic to the human body, is inexpensive, and has excellent jelly-forming ability and thickening properties. For this reason, gelatin is widely used as a component of capsules in the fields of medicine, foods, etc. Among them, gelatin derived from cattle is widely used as a component of capsules.
  • Patent Document 1 As a means for suppressing the insolubilization of the film, for example, a method is known in which inositol phosphate is mixed with gelatin to prepare a film composition, and the composition is used as a film of a capsule (Patent Document 1). 1). Although such a method is conventionally known, it is important to further provide a new means capable of suppressing the insolubilization of the film.
  • the present invention aims to provide a new means capable of suppressing the insolubilization of a film containing gelatin.
  • the present inventors have conducted intensive studies in view of the above-mentioned problems, and, as compared with the case where mint oil, parsley seed oil, or menthol oil is used in combination with cow-derived gelatin, these components are used in combination with pig-derived or fish-derived gelatin. In this case, it was found that insolubilization of gelatin can be effectively suppressed.
  • the present invention has been completed as a result of further studies based on the findings, and is as follows.
  • Item 1 The content containing at least one selected from the group consisting of peppermint oil, parsley seed oil and menthol oil is encapsulated in a film containing at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin. Capsule characterized in that Item 2.
  • Item 2. The capsule according to Item 1, wherein the content further contains a fatty acid triglyceride, and the content contains mint oil at 28 parts by mass or less based on 100 parts by mass of the fatty acid triglyceride.
  • Item 3. Item 3.
  • Item 4. The capsule according to any one of Items 1 to 3, wherein the content further contains a fatty acid triglyceride, and the content contains menthon oil in an amount of 28 parts by mass or less based on 100 parts by mass of the fatty acid triglyceride.
  • a content containing at least one selected from the group consisting of peppermint oil, parsley seed oil and menthol oil, and a group consisting of pig-derived gelatin and fish-derived gelatin A method for suppressing insolubilization of a coating, which comprises combining with a coating containing at least one selected from the following.
  • the capsule and method of the present invention it is possible to suppress the insolubilization of the film containing at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin.
  • the content containing at least one selected from the group consisting of peppermint oil, parsley seed oil and menthol oil contains at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin.
  • a capsule characterized by being encapsulated in a film is provided.
  • the contents contain at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthol oil.
  • Mint oil is an essential oil obtained by refining the above-ground parts of peppermint by steam distillation, and CAS No. Also known as 8006-90-4. Mint oil is commercially available, and is commercially available as, for example, light-weight white oil (manufactured by Nagaoka Jitsugyo Co., Ltd.), Japanese Pharmacopoeia peppermint oil (manufactured by Ogawa Fragrance Co., Ltd.) and the like.
  • the content of peppermint oil in the contents is not limited, but is preferably 0.2 to 22% by mass, more preferably 0.5 to 20% by mass, and further preferably 1 to 10% by mass.
  • Parsley seed oil is an essential oil obtained from the seeds of parsley. Also known as 8000-68-8. Parsley seed oil is commercially available, for example, as parsley seed oil (manufactured by Koei Kogyo Co., Ltd.) and the like.
  • the content of parsley seed oil in the contents is not limited, but is preferably 0.05 to 22% by mass, more preferably 0.1 to 10% by mass, and further preferably 0.15 to 5% by mass. ..
  • Mentone oil is obtained by debraining the essential oil obtained by steam-distilling a plant belonging to the genus Mint and separating it into decerebrated oil and crude brain.
  • Mentone oil is commercially available, and is commercially available, for example, as Mentone oil (manufactured by Nagaoka Jitsugyo Co., Ltd.).
  • Mentone oil is commercially available, and is commercially available, for example, as Mentone oil (manufactured by Nagaoka Jitsugyo Co., Ltd.).
  • menthol oil contains mentone as a main component
  • the mint oil contains menthol as a main component.
  • the content of menthol oil in the contents is not limited, but is preferably 1 to 22% by mass, more preferably 3 to 18% by mass, and further preferably 5 to 15% by mass.
  • the content of the present invention contains at least two kinds selected from the group consisting of mint oil, parsley seed oil and menthol oil
  • the content of mint oil, parsley is preferably 0.2 to 30% by mass, more preferably 5 to 25% by mass, further preferably 10 to 20% by mass. It is illustrated.
  • the content of the present invention is not limited to this, but preferably further contains a fatty acid triglyceride.
  • Fatty acid triglyceride is a compound having a structure in which three fatty acids are ester-bonded to one glycerol.
  • the fatty acid ester-bonded to glycerol may be a saturated fatty acid or an unsaturated fatty acid, and may be a straight chain fatty acid or a branched chain fatty acid.
  • the number of carbon atoms of the fatty acid is not limited, but fatty acids having preferably 8 to 22 carbon atoms, more preferably 10 to 21 carbon atoms, and further preferably 12 to 20 carbon atoms are exemplified.
  • fatty acid caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, behenic acid, lignoceric acid, etc. It is illustrated.
  • the three fatty acids bound to one glycerol may be the same, only two may be the same, or different from each other.
  • the fatty acid triglyceride may be used alone or in combination of two or more.
  • Fatty acid triglycerides include, for example, sunflower oil, safflower oil, rapeseed oil, olive oil, cottonseed oil, soybean oil, sesame oil, corn oil, peanut oil, vegetable oils such as grape oil and palm oil, animal oils such as lard, fish oil and beef tallow. Contains a lot. Therefore, these vegetable oils, animal oils and the like may be used for the contents. These may be used alone or in combination of two or more.
  • the present invention is not limited, but the peppermint oil is preferably 28 parts by mass or less, more preferably 100 parts by mass of the fatty acid triglyceride in the content.
  • the amount is, for example, 0.5 to 27 parts by mass, more preferably 0.5 to 20 parts by mass, and particularly preferably 1 to 12 parts by mass.
  • the present invention is not limited, but the content of parsley seed oil is not more than 28 parts by mass, more preferably 0, based on 100 parts by mass of the fatty acid triglyceride. 1 to 27 parts by mass, more preferably 0.2 to 15 parts by mass, particularly preferably 0.2 to 12 parts by mass.
  • the present invention is not limited, but the content of menthon oil is 28 parts by mass or less, more preferably 1 to 100 parts by mass of the fatty acid triglyceride. 27 parts by mass, more preferably 1 to 20 parts by mass, particularly preferably 5 to 20 parts by mass.
  • the content of the fatty acid triglyceride in the content is not limited, but is preferably 60 to 99.95% by mass, more preferably 70 to 99.9% by mass, and further preferably 75 to 99.8% by mass.
  • the content of fatty acid triglyceride in the content is not limited, but is preferably 60 to 99.9 mass%, more preferably 65 to 99.5.
  • the amount is, for example, 70 to 99% by mass, and more preferably 70 to 99% by mass.
  • the content of fatty acid triglyceride in the content is not limited, but is preferably 65 to 99.95% by mass, more preferably 70 to 99.95% by mass.
  • the amount is, for example, 9% by mass, more preferably 75 to 99.8% by mass.
  • the content of fatty acid triglyceride in the content is not limited, but is preferably 65 to 99% by mass, more preferably 70 to 97% by mass, and further It is preferably 75 to 95% by mass.
  • the contents further contain any component such as a pharmaceutically acceptable component, a cosmetically acceptable component, and an edible component as long as the effects of the present invention are not impaired.
  • a pharmaceutically acceptable component such as a pharmaceutically acceptable component, a cosmetically acceptable component, and an edible component as long as the effects of the present invention are not impaired.
  • an edible component is preferable.
  • the form of the content is not limited, and may be solid (powder, granule, etc.), semi-solid (gel (jelly), cream, paste, etc.), liquid or the like.
  • the form of the contents is preferably semi-solid or liquid.
  • the content may be produced according to the procedure for producing the content contained in a conventionally known capsule, for example, at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthol oil, and if necessary.
  • a fatty acid triglyceride and, if necessary, the above optional components may be appropriately mixed and prepared.
  • the film contains at least one selected from the group consisting of gelatin derived from swine and gelatin derived from fish.
  • the swine-derived gelatin and fish-derived gelatin may be any gelatin that has been conventionally used in the fields of foods, pharmaceuticals, quasi-drugs, and the like, and edible gelatin is preferable.
  • the gelatin is a chemically modified gelatin such as acid- and/or alkali-treated gelatin, acylated gelatin, etc., which is made from pig or fish skin, bone, tendon, ligament, scale, etc., and hydrolysis of gelatin. Examples include gelatin such as things. These gelatins may be used alone or in combination of two or more.
  • Pig-derived gelatin and fish-derived gelatin are commercially available, and are commercially available from, for example, Nippi Co., Ltd., Nitta Gelatin Co., Ltd., Zerais Co., Rousselott, Weishhardt, etc.
  • Pork-derived gelatin and fish-derived gelatin are not limited as long as they are present, but the jelly strength (Bloom value) of the gelatin may be appropriately selected and used.
  • the jelly strength of gelatin is preferably in the range of 50 to 350 g, more preferably 80 to 300 g.
  • the jelly strength of gelatin is measured according to JIS K-6503 (2001). Specifically, the surface of the jelly prepared by cooling a 6.67 mass% gelatin aqueous solution at 10° C. for 17 hours is 2 minutes.
  • the jelly strength is defined as the load (g) required to push down by 4 mm with a 1 inch (12.7 mm) diameter plunger.
  • the content of at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin in the coating is not limited, but the total amount of at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin is The content is preferably 15 to 85% by mass, more preferably 20 to 80% by mass, and further preferably 25 to 75% by mass.
  • a group consisting of peppermint oil, parsley seed oil and menthol oil based on 100 parts by mass of at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin.
  • the total amount of at least one selected from the group is preferably 1 to 50 parts by mass, more preferably 3 to 45 parts by mass, further preferably 5 to 35 parts by mass.
  • the film may further contain any component such as a pharmaceutically acceptable component, a cosmetically acceptable component, and an edible component, if necessary, as long as the effect of the present invention is not impaired. Good.
  • a pharmaceutically acceptable component such as a pharmaceutically acceptable component, a cosmetically acceptable component, and an edible component, if necessary, as long as the effect of the present invention is not impaired.
  • an edible component is preferable.
  • the coating does not contain bovine-derived gelatin.
  • a plasticizer will be described as an example of the optional component.
  • Glycerin as a plasticizer; glycols such as propylene glycol and polyethylene glycol; sucrose, fructose, sorbitol, mannitol, corn syrup, etc. Liquid saccharides; crystalline cellulose, low-substituted hydroxypropyl cellulose, water-insoluble cellulose such as ethyl cellulose, and the like. Any of these may be used alone or in combination of two or more.
  • the content of the plasticizer in the film is not limited, but is preferably 1 to 45% by mass, more preferably 5 to 35% by mass, and further preferably 10 to 30% by mass.
  • the film may be produced according to a conventionally known procedure for producing a film used for capsules, and for example, at least one selected from the group consisting of swine-derived gelatin and fish-derived gelatin and, if necessary, the above-mentioned optional components. May be appropriately mixed and prepared.
  • the capsule contains the above-mentioned contents in the above-mentioned film.
  • the capsule may be produced according to a conventionally known procedure for producing a capsule, for example, at least one selected from the group consisting of peppermint oil, parsley seed oil and menthol oil, and if necessary, a fatty acid triglyceride, and further if necessary.
  • the content prepared by appropriately mixing the above-mentioned arbitrary components is appropriately mixed with at least one selected from the group consisting of swine-derived gelatin and fish-derived gelatin and, if necessary, the above-mentioned arbitrary components. It can be produced by encapsulating the prepared film (capsule).
  • the capsule of the present invention may be produced by encapsulating the content in the film according to a conventionally known procedure for producing a capsule, such as filling the content in the film or encapsulating the content with the film.
  • the capsule of the present invention may be a soft capsule or a hard capsule.
  • examples of the shape of the capsule include an oval (football) type, an oblong (oblong ellipse) type, a round (spherical) type, a tear type, a triangle, and the like. It is preferably not limited as long as it can be taken.
  • the major axis is preferably 6 to 20 mm
  • the minor axis is 4 to 15 mm
  • the minor axis is 4 to 10 mm.
  • the capsule of the present invention may be used orally or parenterally, preferably orally.
  • the mode of use of the capsule is not limited and may be appropriately set according to the purpose. Illustrating the case of oral use as the mode of use, food compositions (including beverages, foods with health claims (foods for specified health uses, foods with nutritional function, foods with functional claims, supplements, etc.), health supplements, diseases (Including foods for personal use), pharmaceutical compositions, quasi-drug compositions, feed compositions, and food compositions, pharmaceutical compositions, quasi-drug compositions, additives for feed, etc. You can The capsule of the present invention may be swallowed promptly, or may be swallowed for a certain period of time in the oral cavity and then swallowed.
  • the subject to whom the capsule of the present invention is applied is not limited, and examples thereof include humans and non-human mammals.
  • mammals other than humans include animals such as guinea pigs, rabbits, dogs, cats, monkeys, and chimpanzees.
  • the capsule of the present invention by using at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthol oil, it is possible to effectively insolubilize a film containing pig-derived gelatin or fish-derived gelatin. Can be suppressed.
  • the present invention also provides a content and a capsule having a film containing the content, the content containing at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthol oil, and pork.
  • a method for suppressing the insolubilization of a film is provided, which is characterized by combining with a film containing at least one selected from the group consisting of gelatin derived from fish and gelatin derived from fish.
  • at least one selected from the group consisting of peppermint oil, parsley seed oil and menthol oil, at least one selected from the group consisting of pig-derived gelatin and fish-derived gelatin, contents, film, capsules, etc. Will be described in the same manner as described above.
  • the method uses a content containing at least one selected from the group consisting of peppermint oil, parsley seed oil, and menthol oil, at least 1 selected from the group consisting of swine-derived gelatin and fish-derived gelatin. It can be said that it can be carried out by encapsulating in a film containing seeds.
  • the present invention as described above, it is possible to suppress the insolubilization of the film containing at least one selected from the group consisting of swine-derived gelatin and fish-derived gelatin. Allows for proper release.
  • Test example Preparation of contents and film Mint oil and fatty acid triglyceride were mixed as contents according to the composition of the following Table 1 to obtain transparent liquids (Examples 1 to 6 and Comparative Examples 1 to 3). Transparent liquids were obtained according to the compositions shown in Table 2 below (Examples 7 to 12 and Comparative Examples 4 to 6) in the same manner as described above except that menthol oil was used instead of peppermint oil. Transparent liquids were obtained according to the compositions shown in Table 3 below (Examples 13 to 18 and Comparative Examples 7 to 9) except that parsley seed oil was used instead of peppermint oil. Transparent liquids were obtained according to the compositions of the following Table 4 in the same manner as above except that mint flavor or lemon flavor was used instead of peppermint oil (Comparative Examples 10 to 15). No solid matter was visually observed in any of the obtained liquids.
  • Mint oil is the trade name of light-weight white oil (made by Nagaoka Jitsugyo Co., Ltd.), menton oil is the trade name of Menton oil 95% (made by Nagaoka Jitsugyo Co., Ltd.), and parsley seed oil is the trade name of parsley seed oil (Koei Kogyo Co., Ltd.).
  • Mint) mint flavor is trade name Spearmint oil (Takasago International Co., Ltd.)
  • lemon flavor is trade name Lemon Oil (Ogawa Fragrance Co., Ltd.)
  • fatty acid triglyceride is trade name J Sunflower White Oil (J-Oil Co., Ltd.) Mills) was used.
  • Sunflower oil generally contains about 95 to 100% by mass of fatty acid triglyceride, and contains fatty acid triglyceride containing oleic acid and linoleic acid as main constituent fatty acids.
  • Pig-derived gelatin is trade name KKSC (jelly strength described by the manufacturer (the same applies below) 250-280 g)
  • fish-derived gelatin is trade name SCG-230L (jelly strength 230-270 g)
  • beef-derived gelatin is trade name #250 ( Jelly strength of 235 to 265 g (all manufactured by Nitta Gelatin Co., Ltd.) was used.
  • the jelly strength is a value measured according to JIS K-6503 (2001). Specifically, the surface of a jelly prepared by cooling a 6.67 mass% gelatin aqueous solution at 10° C. for 17 hours is used. The load (g) was required to push down by 4 mm with a 1/2 inch (12.7 mm) diameter plunger.
  • peppermint oil, menthol oil, and parsley seed oil are excellent in suppressing the insolubilization of the film containing pig-derived gelatin and fish-derived gelatin.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Le but de la présente Invention est de fournir un nouveau moyen capable de supprimer l'insolubilisation d'un revêtement qui comprend de la gélatine. La solution selon l'invention porte sur une capsule caractérisée en ce qu'un ingrédient qui comprend au moins un élément choisi dans le groupe constitué par l'huile de menthe poivrée, l'huile de graines de persil, et l'huile de menthone est contenue dans un revêtement qui comprend au moins un élément choisi dans le groupe constitué de gélatine dérivée de porc et de gélatine dérivée de poisson.
PCT/JP2019/049391 2018-12-28 2019-12-17 Capsule Ceased WO2020137694A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-247735 2018-12-28
JP2018247735A JP7362248B2 (ja) 2018-12-28 2018-12-28 カプセル剤

Publications (1)

Publication Number Publication Date
WO2020137694A1 true WO2020137694A1 (fr) 2020-07-02

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JP (1) JP7362248B2 (fr)
TW (1) TWI841641B (fr)
WO (1) WO2020137694A1 (fr)

Citations (6)

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Publication number Priority date Publication date Assignee Title
JPH0278613A (ja) * 1988-09-13 1990-03-19 Taisho Pharmaceut Co Ltd 精油含有軟カプセル
WO2004071217A1 (fr) * 2003-02-12 2004-08-26 Mw Encap Limited Capsule aromatisante pour aliments
JP2007523904A (ja) * 2004-02-17 2007-08-23 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 被覆された、球状のシームレス型充填カプセル
JP2012213357A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 経口消臭組成物
WO2013100013A1 (fr) * 2011-12-28 2013-07-04 富士カプセル株式会社 Revêtement de capsule molle
JP2015193579A (ja) * 2014-03-31 2015-11-05 小林製薬株式会社 ゼラチンカプセル剤およびその製造方法

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ES2134743B1 (es) 1998-02-06 2000-05-01 Biocosmetics Sl Composicion para el tratamiento de la halitosis.
JP4895422B2 (ja) * 2000-12-07 2012-03-14 ライオン株式会社 呼気清涼化剤
KR100490279B1 (ko) 2002-07-18 2005-05-17 주식회사 서흥캅셀 구취제거 및 구강 청량 효과를 지닌 젤라틴 연질캅셀제
JP5183104B2 (ja) 2006-06-19 2013-04-17 森下仁丹株式会社 口臭除去用多重ソフトカプセル
JP6084468B2 (ja) 2013-01-24 2017-02-22 アリメント工業株式会社 シビレ緩和持続性唾液分泌促進剤、その製造方法、及びシビレ緩和持続性唾液分泌促進食品

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0278613A (ja) * 1988-09-13 1990-03-19 Taisho Pharmaceut Co Ltd 精油含有軟カプセル
WO2004071217A1 (fr) * 2003-02-12 2004-08-26 Mw Encap Limited Capsule aromatisante pour aliments
JP2007523904A (ja) * 2004-02-17 2007-08-23 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 被覆された、球状のシームレス型充填カプセル
JP2012213357A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 経口消臭組成物
WO2013100013A1 (fr) * 2011-12-28 2013-07-04 富士カプセル株式会社 Revêtement de capsule molle
JP2015193579A (ja) * 2014-03-31 2015-11-05 小林製薬株式会社 ゼラチンカプセル剤およびその製造方法

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Title
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SUZUKI, KEIJI: "Raw Materials, Production, and the Properties of Gelatin", JOURNAL OF THE SOCIETY OF PHOTOGRAPHIC SCIENCE AND TECHNOLOGY OF JAPAN, vol. 67, no. 4, 2004, pages 379 - 385, XP055722825, DOI: 10.11454/photogrst1964.67.379 *

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JP2020105140A (ja) 2020-07-09
TWI841641B (zh) 2024-05-11
TW202027731A (zh) 2020-08-01

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