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WO2020124583A1 - Système de surveillance de la position de tumeursen temps réel et procédé de surveillance associé - Google Patents

Système de surveillance de la position de tumeursen temps réel et procédé de surveillance associé Download PDF

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Publication number
WO2020124583A1
WO2020124583A1 PCT/CN2018/122782 CN2018122782W WO2020124583A1 WO 2020124583 A1 WO2020124583 A1 WO 2020124583A1 CN 2018122782 W CN2018122782 W CN 2018122782W WO 2020124583 A1 WO2020124583 A1 WO 2020124583A1
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WO
WIPO (PCT)
Prior art keywords
tumor
opening
closing door
mlc
real
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2018/122782
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English (en)
Chinese (zh)
Inventor
李林涛
郎锦义
秦远
王培�
黎杰
康盛伟
唐斌
吴凡
黄娜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Cancer Hospital
Original Assignee
Sichuan Cancer Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Cancer Hospital filed Critical Sichuan Cancer Hospital
Priority to PCT/CN2018/122782 priority Critical patent/WO2020124583A1/fr
Publication of WO2020124583A1 publication Critical patent/WO2020124583A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy

Definitions

  • the invention relates to the technical field of lung tumor tracking, in particular to a real-time tumor position monitoring system and monitoring method thereof.
  • the respiratory gating system is mainly controlled by foreign manufacturers, mainly including the infrared binocular method respiratory gating system from GE, the abdominal pressure-sensitive respiratory gating system from Philips, and an active breathing called ABC Gating system and medical Keda's pre-judgment breathing gating system.
  • GE uses two infrared cameras to sense the surface of the patient's body (mainly the chest and abdomen) and the body surface driven by breathing motion. Movement, and then through a series of algorithms to simulate the image movement caused by breathing movement.
  • Philips' abdominal belt pressure-sensitive breathing gating system The difference between Philips' abdominal belt pressure-sensitive breathing gating system and GE's is the front-end measurement method. Philips uses an abdominal belt that can sense pressure changes and is tied to the chest and abdomen of the person being measured. The movement of the watch to drive the girth leads to the pressure change and the measurement. The difference in the backhaul lies in the algorithm.
  • ABC active breathing gating is mainly used in radiotherapy. Its principle is to pause breathing movement through passive apnea, and at the same time, the accelerator emits radiation to start treatment, to achieve the purpose of precise treatment. This method often requires the patient to be treated to apnea for up to 40 ⁇ 60s, which is very, very difficult for patients with diseases in their lungs.
  • a medical Kodak 4D system which is also used in accelerator treatment. The principle is to improve the beam output of the accelerator through a computer algorithm. The disadvantage is that there is no measurement, but an implementation of calculation by algorithm.
  • the purpose of the present invention is to overcome the shortcomings of the prior art, provide a compact, more accurate tracking of tumor movement caused by respiratory movement, provide favorable conditions for subsequent tumor treatment, a simple tracking method, a real-time tumor position monitoring system and its monitoring method.
  • a real-time tumor position monitoring system which includes a respiratory velocimeter, a nose MLC drive mechanism and a PLC controller
  • the respiratory velocimeter includes a velocimeter body
  • the velocimeter body A cavity is opened, an air inlet pipe is provided on the top of the rheometer body, and a horn tube and an air outlet pipe are respectively provided on the left and right sides of the rheometer body.
  • the horn tube, the air outlet pipe and the air inlet pipe are all in communication with the cavity.
  • a flow meter is arranged on the air outlet pipe, a first opening and closing door is hinged at the end of the air outlet pipe, a fan is arranged in the air inlet pipe, and a second opening and closing door is hinged in the cavity and located on the top wall of the cavity ,
  • the second opening and closing door is located under the air intake pipe
  • the machine head MLC drive mechanism includes two longitudinal guide rails, the longitudinal guide rail is provided with two sliders that can slide along the longitudinal guide rail, and the slider is provided with a guide sleeve
  • a horizontal guide rail is provided between the two opposite guide sleeves, and an MLC is provided between the two horizontal guide rails.
  • the PLC controller is electrically connected to the flow meter and the fan.
  • a cover plate is provided on the top of the intake pipe.
  • the cover plate is provided with a through hole communicating with the intake pipe.
  • the rotating shaft of the fan is rotatably installed on the cover plate.
  • a strap is provided outside the body of the flow meter.
  • the MLC is composed of each pair of lead blades that can move independently.
  • the method for monitoring the tumor position in real time by the system includes the following steps:
  • the patient is strapped to the head, the horn tube is facing the mouth and the contact is strict;
  • the gas enters the cavity through the horn tube, and the airflow blows towards the second opening and closing door.
  • the second opening and closing door rotates to the right around the hinge point under the action of air pressure, and the second opening and closing door closes the intake pipe; then the gas Entering the air outlet pipe, the first opening and closing door rotates to the right around the hinge point under the action of air pressure, and the gas exhaled by the human body can be discharged.
  • the flow meter measures the flow rate and converts the flow signal into an electrical signal and transmits it to the PLC control devices, PLC controller calculates the amount of expiratory patient X 1; CX while using lung of a patient image scanning, when the detected expiratory volume of X 1, Y 1 in the longitudinal position of the tumor in the lung;
  • a negative pressure is formed in the cavity.
  • the first opening and closing door rotates to the left around the hinge point and buckles on the air outlet pipe, and the outside air enters the intake pipe, and the second opening and closing door is hinged around the air pressure
  • step S5 When tracking the tumor, put the patient on his back and make his lungs face MLC; bring the patient with the respiratory velocimeter for breathing, at this time the instantaneous respiratory volume is detected, combined with the curve in step S4 to find the instantaneous respiratory volume
  • the invention has the following advantages: the invention more accurately tracks the tumor movement caused by respiratory movement, provides favorable conditions for subsequent tumor treatment, and the tracking method is simple.
  • Figure 1 is a schematic diagram of the structure of the respiratory velocimeter
  • Figure 2 is a schematic diagram of the structure of the head MLC drive mechanism
  • Figure 3 is a front view of Figure 2;
  • FIG. 4 is an operation flowchart of the present invention.
  • 1-flow meter body 2-cavity, 3-intake pipe, 4-horn tube, 5-outlet pipe, 6-flow meter, 7-first opening and closing door, 8-fan, 9-second Opening and closing doors, 10-longitudinal guide, 11-slider, 12-guide sleeve, 13-MLC, 14-cover plate, 15-bandage, 16-leaf grating, 17-transverse guide.
  • a real-time tumor position monitoring system includes a respiratory velocimeter, a nose MLC drive mechanism and a PLC controller.
  • the respiratory velocimeter includes a velocimeter body 1 and an external portion of the velocimeter body 1
  • a strap 15 is provided, a cavity 2 is opened in the flow meter body 1, an intake pipe 3 is provided on the top of the flow meter body 1, a horn tube 4 and an air outlet pipe 5 are respectively provided on the left and right sides of the flow meter body 1, a horn
  • the tube 4 is made of rubber material and can be closely attached to the mouth.
  • the horn tube 4, the air outlet tube 5 and the air inlet tube 3 are all in communication with the cavity 2.
  • the air outlet tube 5 is provided with a flow meter 6
  • a first opening and closing door 7 is hinged at the end of the air pipe 5
  • a fan 8 is provided in the intake pipe 3
  • a second opening and closing door 9 is hinged in the cavity 2 and located on the top wall of the cavity 2
  • the opening and closing door 9 is located below the intake pipe 3.
  • the MLC driving mechanism of the machine head includes two longitudinal guide rails 10, and two sliders 11 that can slide along the longitudinal guide rails 10 are provided on the longitudinal guide rails 10, and a guide sleeve is provided on the slider 11 12.
  • a horizontal guide rail 17 is provided between the two opposing guide sleeves 12, the horizontal guide rail 17 can move left and right along the guide sleeve 12, and an MLC 13 is provided between the two horizontal guide rails 17, the MLC 13 is independently movable by each pair
  • the lead blade 16 is configured, and the PLC controller is electrically connected to the flow meter 6 and the fan 8.
  • the MLC 13 can move back and forth along the longitudinal rail 10, and can also move left and right along the lateral rail 17, to ensure that the MLC can move in real time with the movement of the tumor.
  • a cover plate 14 is provided on the top of the intake pipe 3, and the cover plate 14 is provided with a through hole communicating with the intake pipe 3, so that outside air can enter the intake pipe 3 through the through hole.
  • the rotating shaft of the fan 8 is rotatably installed on the cover plate 14.
  • the method for monitoring the tumor position in real time by the system includes the following steps:
  • the patient is brought to the head via the strap 15 and the horn tube 4 is facing the mouth and the contact is strict;
  • the gas enters the cavity 2 through the trumpet tube 4, the airflow blows towards the second opening and closing door 9, the second opening and closing door 9 rotates to the right around the hinge point under the action of air pressure, and the second opening and closing door 9 Close the air intake pipe 3 to prevent the exhaled gas from running out of the air intake pipe 3, and the flow rate of the exhaled gas is read by the 6 flow meter; then the gas enters the air outlet pipe 5, and the first opening and closing door 7 is hinged around under the action of air pressure The point rotates to the right, the gas exhaled by the human body can be discharged.
  • the flow meter 6 measures the flow rate and converts the flow signal into an electrical signal to the PLC controller.
  • the PLC controller calculates the patient's exhaled volume as X 1 ; CX while using lung of a patient image scanning, when the detected expiratory volume of X 1, Y 1 in the longitudinal position of the tumor in the lung;
  • a negative pressure is formed in the cavity 2.
  • the first opening and closing door 7 rotates to the left around the hinge point and buckles on the air outlet pipe 5 to prevent outside air from entering the air outlet pipe 5 while outside air enters the air inlet pipe
  • the second opening and closing door 9 rotates to the left around the hinge point under the action of air pressure, the second opening and closing door opens, and the external air flow enters the cavity through the cavity 2 and the trumpet tube 4 in sequence; during the suction process, the fan 8 Turning, the fan 8 converts the rotation signal into telecommunications and transmits it to the PLC controller.
  • the PLC controller calculates the patient's inspiratory volume X 2 ; at the same time, the CX is used to scan the patient's lungs and the inspiratory volume is detected as X 2 When, the longitudinal position of the tumor in the lung is Y 2 ;
  • the monitoring method can more accurately track the tumor movement caused by the respiratory movement and provide favorable conditions for subsequent tumor treatment.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un système de surveillance de la position de tumeurs en temps réel, comprenant un pneumotachomètre, un mécanisme d'entraînement de MLC de pièce à main et un contrôleur PLC. Le pneumotachomètre comprend un corps de pneumotachomètre (1), le côté gauche et le côté droit du corps de pneumotachomètre (1) sont respectivement pourvus d'un tube en forme de trompette (4) et d'un tube d'expiration (5), un débitmètre (6) est disposé sur le tube d'expiration (5) et la portion d'extrémité du tube d'expiration (5) est fixée de manière articulée à une première vanne d'ouverture/fermeture (7). Le mécanisme d'entraînement de MLC de pièce à main comprend deux rails de guidage longitudinaux (10), les rails de guidage longitudinaux (10) sont chacun pourvus de deux curseurs (11) aptes à coulisser le long des rails de guidage longitudinaux (10), les curseurs (11) sont chacun pourvus d'un manchon de guidage (12), un rail de guidage horizontal (17) est disposé entre deux manchons de guidage opposés (12) et un MLC est disposé entre les deux rails de guidage horizontaux (17). L'invention concerne en outre un procédé de suivi. Le système peut suivre plus précisément des mouvements de tumeur provoqués par des mouvements respiratoires, offre des conditions favorables pour un traitement de tumeur ultérieur et permet un procédé de suivi simple.
PCT/CN2018/122782 2018-12-21 2018-12-21 Système de surveillance de la position de tumeursen temps réel et procédé de surveillance associé Ceased WO2020124583A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/122782 WO2020124583A1 (fr) 2018-12-21 2018-12-21 Système de surveillance de la position de tumeursen temps réel et procédé de surveillance associé

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/122782 WO2020124583A1 (fr) 2018-12-21 2018-12-21 Système de surveillance de la position de tumeursen temps réel et procédé de surveillance associé

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WO2020124583A1 true WO2020124583A1 (fr) 2020-06-25

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101623198A (zh) * 2008-07-08 2010-01-13 深圳市海博科技有限公司 动态肿瘤实时跟踪方法
WO2012066494A2 (fr) * 2010-11-19 2012-05-24 Koninklijke Philips Electronics N.V. Procédé et appareil de compensation d'un mouvement intra-fractionnel
CN103801037A (zh) * 2014-01-24 2014-05-21 深圳市安保科技有限公司 一种便携式呼吸装置
CN104220132A (zh) * 2013-02-28 2014-12-17 深圳市奥沃医学新技术发展有限公司 一种呼吸跟踪装置及放射治疗系统
CN104548386A (zh) * 2013-10-24 2015-04-29 伊利克塔股份有限公司 放射治疗系统中的辅助装置/附件的使用
US9504850B2 (en) * 2013-03-14 2016-11-29 Xcision Medical Systems Llc Methods and system for breathing-synchronized, target-tracking radiation therapy
CN107126192A (zh) * 2017-04-18 2017-09-05 四川省肿瘤医院 一种肿瘤位置实时监测系统及其监测方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101623198A (zh) * 2008-07-08 2010-01-13 深圳市海博科技有限公司 动态肿瘤实时跟踪方法
WO2012066494A2 (fr) * 2010-11-19 2012-05-24 Koninklijke Philips Electronics N.V. Procédé et appareil de compensation d'un mouvement intra-fractionnel
CN104220132A (zh) * 2013-02-28 2014-12-17 深圳市奥沃医学新技术发展有限公司 一种呼吸跟踪装置及放射治疗系统
US9504850B2 (en) * 2013-03-14 2016-11-29 Xcision Medical Systems Llc Methods and system for breathing-synchronized, target-tracking radiation therapy
CN104548386A (zh) * 2013-10-24 2015-04-29 伊利克塔股份有限公司 放射治疗系统中的辅助装置/附件的使用
CN103801037A (zh) * 2014-01-24 2014-05-21 深圳市安保科技有限公司 一种便携式呼吸装置
CN107126192A (zh) * 2017-04-18 2017-09-05 四川省肿瘤医院 一种肿瘤位置实时监测系统及其监测方法

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