WO2020175701A1 - Aqueous dispersion, cosmetic composition and method for producing cosmetic - Google Patents

Abstract

An aqueous dispersion that contains gold particles having an average particle diameter of 200nm or less, and satisfies at least one of the following conditions (1) and (2). (1) When the aqueous dispersion is stored for one year at a temperature of 25°C, the rate of change in the average particle diameter of the gold particles after storage is no more than 30%, and the rate of change in the polydispersity index is no more than 25%. (2) When the aqueous dispersion is stored for one year at a temperature of 4°C, the rate of change in the average particle diameter of the gold particles after storage is no more than 10%, and the rate of change in the polydispersity index is no more than 20%.

Description

Specification

Title of invention: Aqueous dispersion, cosmetic composition, and method for producing cosmetic

[0001] The present disclosure relates to an aqueous dispersion, a cosmetic composition, and a method for producing a cosmetic.

Background technology

[0002] In recent years, an aqueous dispersion in which gold particles are dispersed in a continuous phase such as an aqueous medium has been known, and is expected to be applied in the fields of biosensing materials for detecting biomolecules such as proteins. (Patent Documents 1 to 3). In addition, various physiological functions of gold particles such as anti-inflammatory, anti-aging, and elastic recovery of skin have been reported, and their use in cosmetics is expected (Patent Document 4).

Prior art documents

Patent literature

Patent Document 1: Japanese Patent Laid-Open No. 2009 _ 299 1 12

Patent Document 2: Special Table 2009-501 786 Publication

Patent Document 3: JP 2009_22 1 1 40 JP

Patent Document 4: J o u r n a l o f P h a r m a c e u t i c s Vo l u me 201 8, 1 9 p a g e s

Summary of the invention

Problems to be Solved by the Invention

[0004] Here, according to the inventors of the present invention, the inventors of the present invention diligently studied in order to apply the aqueous dispersion of gold particles to the use of cosmetics. There was room to examine the mixability (storage stability).

[0005] The present disclosure has been made in view of such circumstances, and provides an aqueous dispersion having excellent storage stability when blended in a cosmetic, and a cosmetic composition containing the aqueous dispersion. The purpose is to Moreover, this indication aims at providing the manufacturing method of the cosmetics using such an aqueous dispersion.

Means for solving the problem 〇 2020/175701 2 (:171? 2020/008523

[0006] The aqueous dispersion of the present disclosure contains gold particles having an average particle size of 200 n°! or less, and satisfies at least one of the following conditions (1) and (2).

1年間保管した場合、 保管後の前記金粒子 の平均粒子径の変化率が 3 0 %以内であり、 多分散指数の変化率が 2 5 %以 内である。 (1) Add the above aqueous dispersion to 2

When stored for 1 year, the change rate of the average particle size of the gold particles after storage is within 30% and the change rate of polydispersity index is within 25%.

(2) When the aqueous dispersion is stored at 4°° for 1 year, the average particle size change rate of the gold particles after storage is 10% or less, and the polydispersity index change rate is 20% or less. Is. The polydispersity index of the gold particles is preferably 0.1 or more.

[0007] The aqueous dispersion of the present disclosure may include gold particles having an average particle diameter of 200 n or less, and the polydispersity index of the gold particles may be 0.1 or more.

[0008] The aqueous dispersion of the present disclosure preferably further contains polyvinylpyrrolidone and polyethyleneimine.

[0009] The cosmetic composition of the present disclosure includes the above aqueous dispersion.

[0010] The method for producing a cosmetic according to the present disclosure includes a step of blending the aqueous dispersion with another raw material.

Effect of the invention

[001 1] According to the present disclosure, it is possible to provide an aqueous dispersion having excellent storage stability when blended with a cosmetic, and a cosmetic composition containing the aqueous dispersion. Moreover, the present disclosure can provide a method for producing a cosmetic using such an aqueous dispersion.

MODE FOR CARRYING OUT THE INVENTION

[0012] The aqueous dispersion of the present embodiment contains gold particles having an average particle size of 200 n 0! or less. The aqueous dispersion of the present embodiment further satisfies at least one of the following conditions (1) and (2), or the polydispersity index of gold particles is 0.1 or more.

(1) When the aqueous dispersion was stored at room temperature (25 ^° 〇 for 1 year, the average particle size change rate of the gold particles after storage was within 30%, and the polydispersity index change rate was 25%. Within the following.

(2) When the aqueous dispersion is stored at 4 ^° ◦ for 1 year, the average particle size of gold particles after storage 〇 2020/175701 3 卩(: 171-1? 2020/008523

、 温 度等の範囲で、 抗炎症、 抗老化、 肌の弾性回復等の各種生理機能において優 れている傾向にある。 また、 本実施形態の水性分散体は、 皮膚透過性に優れ る傾向にある。 The rate of change of diameter is within 10%, and the rate of change of polydispersity index is within 20%. When such an aqueous dispersion is blended with cosmetics, it has good compatibility with various additives that are blended with cosmetics, and it is possible to suppress the formation of aggregates in various cosmetic formulations. Generation of aggregates can be suppressed even in a wide range of 1 ^to 1 and temperature. Therefore, the aqueous dispersion of the present embodiment is excellent in storage stability, mixability, and appearance of the aqueous dispersion. Further, the aqueous dispersion of the present embodiment,

In the range of temperature, etc., it tends to be superior in various physiological functions such as anti-inflammatory, anti-aging, and elastic recovery of skin. Further, the aqueous dispersion of the present embodiment tends to have excellent skin permeability.

Thus, the aqueous dispersion of this embodiment can be used for cosmetics.

以下であると好ましく、 1 50 n m以下であると より好ましく、 1 20 n

以下であると更に好ましく、 1 00 n 以下であ ると特に好ましい。 上記金粒子の平均粒子径は、 保存安定性の観点から 5 n

、 より大きいとより好ましく、 25 n m以 上であると更に好ましく、 30 01以上であると特に好ましく、 40 111以 上であるとより更に好ましい。 粒子の平均粒子径は、 動的光散乱法により測 定することができ、 具体的な装置としては、 Ze t c^ s \ 2.e r 3门〇 I 6 r n社製） 等を挙げることができる。 粒子の平均粒子径は、 個 数基準での累積粒度分布における累積 50%となる粒子径 （〇^ 50） であつ てよい。 [0013] The average particle diameter of the gold particles is 200 _n or less, and from the viewpoint of further improving storage stability, it is 1 70 n.

It is preferably not more than 150 nm, more preferably not more than 150 nm, and not more than 120 n

It is more preferably not more than 100 n, particularly preferably not more than 100 n. The average particle size of the gold particles is 5 n from the viewpoint of storage stability.

Is more preferable, 25 nm or more is more preferable, 3001 or more is particularly preferable, and 40 111 or more is still more preferable. The average particle size of the particles can be measured by the dynamic light scattering method, and a specific device can be Ze tc^ s \ 2.er 3 manufactured by I 6 rn) or the like. .. The average particle size of the particles may be the particle size (∘^ 50) at which the cumulative 50% in the cumulative particle size distribution is obtained.

[0014] Further, the particle size (90) at which cumulative 90% in the cumulative particle size distribution of the gold particles is 90% is preferably 400 n or less, more preferably 350 n or less, and 300 n or less. It is more preferable to have.

[0015] Further, the polydispersity index of the gold particles is preferably 0.1 or more, more preferably 0.015 or more, and further preferably 0.2 or more, from the viewpoint of reducing the manufacturing cost. preferable. The polydispersity index of the above gold particles is based on the compatibility with cosmetics and the appearance. 〇 2020/175701 4 (:171? 2020/008523

From the viewpoint of improvement, it may be 0.5 or less, and 0.4 or less. The polydispersity index of gold particles can be measured by the above-mentioned dynamic light scattering method.

[0016] The aqueous dispersion of the present embodiment satisfies at least one of the above conditions (1) and (2). The storage condition may be storage in a dark place without vibration.

The change rate of the average particle size of the gold particles after storage is the absolute value of the difference between the average particle size at the end of storage and the average particle size at the start of storage divided by the average particle size at the start of storage. is there.

Similarly, the rate of change of the polydispersity index of gold particles after storage is the absolute value of the difference between the polydispersity index at the end of storage and the polydispersity index at the start of storage, and is the polydispersity index at the start of storage. It has been divided.

The average particle size of the gold particles after storage and the rate of change of the polydispersity index are both expressed as percentages.

The storage start time may be immediately after the production of the aqueous dispersion, or may be any time after the production. The end of storage may be one year from the start of storage, one year and two months, or one year and five months.

Regarding the condition (1), it is preferable that the rate of change of the polydispersity index of the gold particles after storage for 1 year is within 22%.

Regarding the condition (2), the change rate of the average particle size of the gold particles after storage for 1 year is preferably within 5%, more preferably within 3%. Further, with respect to the condition (2), the rate of change of the polydispersity index of the gold particles after being stored for 1 year is preferably within 15%, more preferably within 10%.

Storage is performed in an environment that can prevent evaporation of water in the aqueous dispersion, and for example, it is preferable to store the aqueous dispersion in a closed container.

The term “within” refers to a range from 0 to a predetermined upper limit. The rate of change of the average particle size after storage at 4° or room temperature may be substantially 0%, but may be greater than 0% and may be 0.1% or more. The rate of change of polydispersity index after storage at 4 ^° or room temperature may be substantially 0%. 〇 2020/175701 5 (:171? 2020/008523

May be larger than 0%, or may be 0.1% or more.

以上であると好ましく、 5

〇!以上であると更に 好ましくい。 金粒子の粒子径の標準偏差は、 化粧品への配合性や外観向上の 観点から、 4 0 n 以下であると好ましい。 金粒子の粒子径の標準偏差は、 上述の動的光散乱法により測定することができる。 [0017] The standard deviation of the particle diameter of the gold particles is preferably larger than 1 _nm , from the viewpoint of reducing the manufacturing cost.

5 or more is preferable, and 5

It is more preferable that it is ◯! The standard deviation of the particle size of the gold particles is preferably 40 n or less from the viewpoints of blendability in cosmetics and improvement of appearance. The standard deviation of the particle size of gold particles can be measured by the above-mentioned dynamic light scattering method.

[0018] The coefficient of variation of the particle diameter of the gold particles is preferably 0.68 or more, more preferably 0.70 or more, and 0.72 or more from the viewpoint of reducing the manufacturing cost. Is more preferable, and 0.75 or more is particularly preferable. The variation coefficient of the particle size of the gold particles is preferably 0.90 or less. The coefficient of variation of the particle diameter of gold particles is the standard deviation of the particle diameter divided by the average particle diameter, and can be calculated from the value measured by the above-mentioned dynamic light scattering method.

[0019] The gold particles may contain components other than gold atoms. The content of gold atoms in the gold particles is preferably 70% by mass or more, more preferably 80% by mass or more, and further preferably 90% by mass or more. Components other than the gold atom include polyacrylic acid, polyvinylpyrrolidone, polyethyleneimine and the like.

[0020] The content of gold particles in the aqueous dispersion is preferably 0.001 to 10 mass% with respect to the total amount of the aqueous dispersion, from the viewpoint of mixability, and the like. It is more preferably ˜50% by mass, and even more preferably ◯0.01˜1% by mass.

[0021] The content of the reducing agent in the aqueous dispersion of the present embodiment is not more than 10 mass because it is easy to combine with other components when added as a cosmetic product and has low irritation to the skin. It is more preferable that it is 5 mass 111 or less, and it is further preferable that it is substantially 0 mass. Examples of the reducing agent include sodium citrate (trisodium citrate, etc.), potassium citrate (tripotassium citrate, etc.), sodium potassium citrate, sodium tartrate, potassium tartrate, sodium potassium tartrate, disaccharides, trisaccharides, Polysaccharide tetrahydroboric acid 〇 2020/175 701 6 卩 (: 171-1? 2020 /008523

Examples include sodium, formic acid, and ascorbic acid.

[0022] The aqueous dispersion may contain a surfactant. The surfactant is not particularly limited, and anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants which are generally used in cosmetics can be used.

Examples of the anionic surfactants include alkyl sulfates, polyoxyethylene alkyl sulfates, polyethylene glycol (M), fatty acid amide monoethanolamine (IV! Machihachi) sulfate, alkylmethyl taurine, olefin sulfonic acid. Examples thereof include salts, alkyl sulfosuccinates, alkyl phosphate ester salts, fatty acid salts, acyl amino acid salts, alkyl lactates, alkyl isethionates and the like.

Cationic surfactants include lauryl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, behenyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, stearyl trimethyl ammonium bromide, dipolyoxyethylene oleyl chloride. Methylammonium, polyoxyethylene behenylylmethylammonium chloride, behenyltrimethylammonium methylsulfate, stearylhydroxypropyltrimethylammonium chloride, dicocoyl dimethylammonium chloride, dialkyl (0 1 2-18) dimethylammonium chloride, chlorinated Dicetyl dimethyl ammonium, distearyl dimethyl ammonium chloride, lanolin fatty acid aminopropyl dimethyl ammonium sulphate, dicocoyl ethyl hydroxyethyl ammonium methyl sulphate, coconut oil alkyl propylene glycol (〇) dimonium chloridolinic acid, amide linoleic acid propyl dimonium chloride Drin rooster, stearamide dopropylmethylamine, dimethyl stearamine, polyoxyethylene (○) coconut oil alkylamine and the like.

Examples of amphoteric surfactants include alkyl betaine-type amphoteric surfactants such as lauryl dimethylamino acetic acid betaine, and amidopropyl betaine laurate. 20/175701 7 卩 (: 171? 2020 /008523

［3—アルキル （ 1 2 , 1 4） オキシ _ 2 —ヒドロキシプロピル］

アルギニン塩酸塩等のアミノ酸型の界面活性 剤等が挙げられる。 Midbetaine-type amphoteric surfactants, hydroxyalkyl ((3 1 2 — 1 4) Carboxybetaine-type amphoteric surfactants such as hydroxyethyl sarcosine, Laurin rooster amidopropyl hydroxysulfobetaine, etc. Amidosulfobetaine-type amphoteric surfactants, cocoolinhodiacetate sodium and other imidazolinium betaine-type amphoteric surfactants, propionate-type amphoteric surfactants such as sodium lauraminopropionate, and lauryldimethylamine oxide Amine-oxide type amphoteric surfactant,

[3-alkyl (1 2, 1 4) oxy _ 2 -hydroxypropyl]

Examples thereof include amino acid type surfactants such as arginine hydrochloride.

The nonionic surfactants include monoglycerin fatty acid ester type nonionic surfactants, polyglycerin fatty acid ester type nonionic surfactants, sorbitan and polyoxyethylene sorbitan type nonionic surfactants. Polyoxyethylene sorbite type nonionic surfactant tetraoleate, Polyoxyethylene hydrogenated castor oil type nonionic surfactant, Pyrrolidonecarboxylic acid (08) Isostearate polyoxyethylene hydrogenated castor Oil type nonionic surfactant, polyoxyethylene fatty acid type nonionic surfactant, polyoxyethylene fatty acid glycerin type nonionic surfactant, polyoxyethylene alkyl ether type nonionic surfactant Agent, polyoxyethylene·polyoxypropylene alkyl ether type nonionic surfactant, polyoxyethylene·polyoxypropylene block polymer type nonionic surfactant, alkanolamide type nonionic surfactant, silane Non-ionic surfactants such as yo-sugar ester type nonionic surfactants, alkylglycoside type nonionic surfactants, polyethylene glycol distearate (Nm) type nonionic surfactants and the like can be mentioned.

You may use these 1 type(s) or 2 or more types. The amount of the surfactant in the aqueous dispersion is preferably 0.01 to 80% by mass based on the total amount of the aqueous dispersion, from the viewpoints of skin irritation and blendability. It is more preferably from 1 to 50% by mass, and further preferably from 0.5 to 40% by mass. [0023] The aqueous dispersion may contain a dispersant. The dispersant is preferably water-soluble. For example, water-soluble polymers derived from natural products such as guar gum, carrageenan, alginate, corn starch, xanthan gum, chondroitin sulfate, hyaluronate, natural products such as carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, cationized guar gum, etc. Semi-synthetic water-soluble polymers with chemically modified raw materials, and water-soluble polymers obtained by chemical synthesis such as polyacrylic acid, polyvinylpyrrolidone, polyalkylene glycol, polyethyleneimine, and polyvinyl alcohol. These may be used alone or in combination of two or more. The amount of the dispersant in the aqueous dispersion is preferably 0.01 to 80% by mass and 0.1 to 50% by mass based on the total amount of the aqueous dispersion, from the viewpoints of skin irritation and blending properties. % Is more preferable, and 0.5 to 40% by mass is further preferable.

The aqueous dispersion preferably contains both polyvinylpyrrolidone and polyethyleneimine. In this case, the content of polyvinylpyrrolidone is preferably 0.1 to 20% by mass, more preferably 0.5 to 15% by mass, and 1.0 to 1% by mass based on the total amount of the aqueous dispersion. More preferably, it is 1.0% by mass. The content of polyethyleneimine is preferably 0.1 to 300 mass ppm, and more preferably 1 to 200 mass ppm, based on the total amount of the aqueous dispersion.

[0024] The aqueous dispersion contains an aqueous medium that is a continuous phase together with the gold particles. The aqueous medium may be water itself, but may also contain other components such as an organic solvent and additives together with water. The additives may include antioxidants and preservatives. Examples of the antioxidant include ascorbic acid and the like. Examples of the preservatives include paraoxybenzoic acid ester, 1,2 hexanediol, citric acid, phenoxyethanol and the like.

[0025] The aqueous dispersion of the present embodiment is C h e m i c a l E n g i n e e r i n g

S c i e n c e Vo l u me 1 7 1 ,2 N o v e m b e r 20

1 Manufactured by known methods described in Ages 233-243, etc. can do. Examples of the raw material of the gold particles include a solution containing a complex ion containing gold in the oxidation state such as a chloroauric acid solution (an aqueous solution of gold (III) chloride tetrahydrate), and the complex ion Gold particles can be obtained by reduction. The aqueous dispersion of the present embodiment can be manufactured by dispersing gold particles in an aqueous medium using a microfluidic device or the like. For example, E u r.

J .P h a r m.B i o p h a r m. 1 1 7, 286 to 29 1 (2

01 7) Method described, E u r. J .P h a r m. B i o p h a r m.

63, 128-133 (2006), a method for preparing an aqueous dispersion using a microfluidic device, and the like can be used.

[0026] The aqueous dispersion of the present embodiment may optionally contain particles other than gold particles (referred to as "other particles"), if desired. Other particles may be contained in one kind or two kinds or more, and examples of such particles include particles of vitamin E having an average particle size of 5 O nm or less and curcuminoid particles having an average particle size of 200 nm or less. Examples thereof include particles and particles of ceramics having an average particle size of 200 nm or less. The vitamin E particles may contain components other than vitamin E, and it is preferable that the vitamin E content is 70% by mass or more based on the total amount of vitamin E particles. The particles of curcuminoid may contain components other than curcuminoid, and it is preferable that the content of curcuminoid is 70% by mass or more based on the total amount of the particles of curcuminide. The particles of the ceramides may contain components other than the ceramides, and it is preferable that the ceramides are contained in an amount of 70% by mass or more based on the total amount of the particles of the ceramides.

[0027] <Cosmetic composition>

The aqueous dispersion of the present embodiment can be made into a cosmetic composition by adding components (additives for cosmetics) usually added to cosmetics. The content of the gold particles in the cosmetic composition is preferably 0.0001% by mass or more, and more preferably 0.0005% by mass, from the viewpoint of further increasing the storage stability of the gold particles in the cosmetic composition. % Or more, more preferably 0.001% by mass or more. In addition, from the viewpoint of ensuring the performance as a cosmetic, 50 〇2020/175701 10 (:171?2020/008523

The amount is less than or equal to %. Examples of various components include those described below.

[0028] Examples of the additive for cosmetics include oily ingredients, powder ingredients, oil gelling agents, aqueous ingredients, water-soluble polymers, ultraviolet absorbers, antioxidants, cosmetic ingredients, preservatives, and the like. However, these additives can be appropriately blended in order to impart various effects.

[0029] The oily component includes hydrocarbons, oils and fats, waxes and ester regardless of the origin of animal oil, vegetable oil, synthetic oil and the like and properties of solid, semi-solid oil, liquid oil, volatile oil and the like. Examples thereof include oils, hydrogenated oils, fatty acids, higher alcohols, silicone oils, lanolin derivatives, oily gelling agents and the like. Specifically, paraffin wax, ceresin wax, microcrystalline wax, Montan wax, Fischer-Tropsch wax, liquid paraffin, squalane, hydrocarbons such as petrolatum, mokuro, mink oil, olive oil, avocado oil, castor oil, macadamian nuts. Oils and fats, beeswax, carnauba wax, candelilla wax, waxes such as gallow, rosin acid pentaerythritol ester, jojoba oil, glyceryl tri-2-ethylhexanoate, isotridecyl isononanoate, cetyl 2-ethylhexanoate, Isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, glyceryl trioctanoate, polyglyceryl diisostearate, glyceryl triisostearate, diglyceryl triisostearate, polyglyceryl triisostearate, diisostearyl malate, diethylhexanoic acid Esters such as neopentyl glycol, oleic acid, isostearic acid, stearic acid, lauric acid, myristic acid, fatty acids such as behenic acid, stearyl alcohol, cetyl alcohol, lauryl alcohol, behenyl alcohol, oleyl alcohol Higher alcohols such as, methyl polysiloxane, methylphenyl polysiloxane, trimethyl silico silicic acid, cross-linked polyether modified methyl polysiloxane, methacryl modified methyl polysiloxane, oleyl modified methyl polysiloxane, polyvinyl pyrrolidone modified methyl polysiloxane , Silicone oils such as polyether modified polysiloxane, lanolin, 〇 2020/175 701 1 1 卩 (: 171-1? 2020 /008523

Lanolin acetate, lanolin fatty acid isopropyl, lanolin derivatives such as lanolin alcohol, aluminum isostearate, calcium stearate,

Examples thereof include oily gelling agents such as 12-hydroxystearic acid, and one or more of these can be used. Among these, low molecular weight ester oils such as glyceryl tri-2-ethylhexanoate, isononyl isononanoate, and neopentyl glycol diethylhexanoate are preferable from the viewpoint of spreading and spreading.

[0030] The powder component is not particularly limited depending on its shape such as spherical, plate-like, needle-like, etc., particle size such as fog-like, fine particles, pigment grade, particle structure such as porous and non-porous, and the like. Examples include powders, glitter powders, organic powders, pigment powders, metal powders, composite powders and the like. Specifically, white inorganic pigments such as titanium oxide, zinc oxide, cerium oxide, and barium sulfate, colored inorganic pigments such as iron oxide, carbon black, chromium oxide, chromium hydroxide, navy blue, and ultramarine, talc, muscovite, Phlogopite, Phlogopite, Biotite, Synthetic Mica, Sericite, Synthetic Sericite, Kaolin, Silicon Carbide, Bentonite, Smectite, Aluminum Oxide, Magnesium Oxide, Zirconium Oxide, Antimony Oxide, Silica Soil, aluminum silicate, magnesium aluminum metasilicate, calcium silicate, barium silicate, magnesium silicate, calcium carbonate, magnesium carbonate, hydroxyapatite, boron nitride, white powder such as silica, titanium dioxide coated mica, Titanium dioxide coated bismuth oxychloride, iron oxide coated mica titanium, iron oxide mica, dark blue treated mica titanium, carmine treated mica titanium, bismuth oxychloride, luster powder such as fish scale foil, polyamide resin, polyethylene resin, Polyacryl resin, polyester resin, fluorine resin, cellulose resin, polystyrene resin, styrene-acrylic copolymer and other cobomer resin, polypropylene resin, silicone resin, urethane resin and other organic polymer resin powder Body, zinc stearate,! \1 _ Organic low molecular weight powders such as acyl lysine, starch, silk powder, natural organic powders such as cellulose powder, Red No. 201, Red No. 202, Red No. 205, Red No. 2 26 No., Red No. 228, Orange No. 203, Orange No. 204, Blue 〇 2020/175 701 12 boxes (: 171-1? 2020 /008523

Organic pigment powders such as color No. 4 04, yellow No. 4 01, red No. 3, red No. 104, red No. 106, orange No. 205, yellow No. 4, yellow No. 5, green Organic pigment powders such as zirconium No. 3 and blue No. 1 such as barium or aluminum lake or metal powders such as aluminum powder, gold powder, silver powder, titanium mica coated with fine particles of titanium oxide, titanium mica coated with fine particles of zinc oxide, barium sulfate Composite powder of coated mica titanium, titanium oxide silicon dioxide, zinc oxide silicon dioxide, etc., polyethylene terephthalate/aluminum/epoxy laminated powder, polyethylene terephthalate/polyolefin laminated film powder, polyethylene terephthalate/polyethylene methacrylate laminated film powder lame agent, tar Examples thereof include pigments and natural pigments. These powders may be used alone or in combination of two or more, and may be used in combination. These powder components include fluorine compounds, silicone compounds, metal soaps, lecithin, hydrogenated lecithin, collagen, hydrocarbons, higher fatty acids, higher alcohols, esters, wax quarantis, waxes, surfactants, etc. It may be surface-treated with one or more of

[0031] Examples of the oil gelling agent include dextrin fatty acid ester, sucrose fatty acid ester, starch fatty acid ester, hydroxystearic acid, calcium stearate, hydrophobic fumed silica, organically modified bentonite, and the like. Alternatively, two or more kinds may be used.

[0032] The aqueous component may be water or any component soluble in water, and in addition to water, for example, glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol and polyethylene glycol. Glycerin, diglycerin, polyglycerin and other glycerols, aloe vera, witch hazel, hamamelis, cucumber, lemon, lavender, mouth extract and other plant extracts.

[0033] Examples of the water-soluble polymer include guar gum, sodium chondroitin sulfate, hyaluronic acid, gum arabic, sodium alginate, carrageenan, mucopolysaccharide, collagen, elastin, keratin, and the like, and methylcelluloe. 〇 2020/175 701 13 卩 (: 171-1? 2020 /008523

And semi-synthetic ones such as hydroxyethyl cellulose and carboxymethyl cellulose, and synthetic ones such as carboxyvinyl polymer, polyvinyl alcohol and sodium polyacrylate.

[0034] Examples of the ultraviolet absorber include benzophenone-based, eight-eight-octane-based, cinnamic acid-based, salicylic acid-based, 4-1 6 "I-butyl-4'-methoxydibenzoylmethane, oxybenzone and the like.

[0035] Examples of the antioxidant include vitamin C such as tocopherol and ascorbic acid.

[0036] Examples of the beauty ingredient include vitamins, proteins, anti-inflammatory agents, herbal medicines, and the like.

[0037] Examples of preservatives include paraoxybenzoic acid ester, phenoxyethanol and the like.

[0038] Further, various components other than the above include, for example, humectants, film-forming agents, anti-fading agents, defoamers, fragrances, fluorine-based oil agents such as perfluoropolyether, perfluorodecalin and perfluorooctane; Polyhydric alcohols, sugars, amino acids, various polymers, ethanol, thickeners, 1 ^to 1 regulators, blood circulation promoters, cooling sensitizers, bactericides, skin activating agents, etc. are also within the range that do not impair the effects of the present disclosure. It can be mixed within.

[0039] Further, the cosmetic composition of the present embodiment is not particularly limited in its dosage form and product form, and may be a water-in-oil type, an oil-in-water type, a water dispersion type, a press type, a solid agent, a powder. In addition, the product form (cosmetics) can be in the form of facial cleansing cream, cleansing, massage cream, pack, lotion, milky lotion, cream, beauty essence, makeup. Base, skin cosmetics such as sunscreen, foundation, water white powder, eye shadow, eyeliner, mascara, eyebrow, concealer, lipstick, lip cream, and other finishing cosmetics, hair mist, shampoo, rinse, treatment, hair Examples include tonics, hair creams, pomades, tics, liquid hair styling products, set hair lotions, hair spray cosmetics, hair cosmetics such as hair dyes, powder sprays, antiperspirants such as mouth rinses, etc. be able to. Among these, solid formulations such as foundation and face powder are cosmetics in which the effects of the present disclosure are easily exhibited.

[0040] The method for producing the cosmetic composition or the cosmetic is not particularly limited, and the aqueous dispersion of the present embodiment may be used as another raw material (cosmetic additive, etc.) for producing a cosmetic. ).

Example

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited to the following examples.

<Preparation of gold particle aqueous dispersion>

By a known method for preparing an aqueous dispersion using a microfluidic device, gold is dispersed in an aqueous solution containing a protective material such as a surfactant and a chelating agent to form a transparent aqueous dispersion containing gold particles. Obtained. When the obtained aqueous dispersion was measured using a dynamic light scattering measuring device (trade name: Z etasizer Nano, manufactured by Malvern Co.), the average particle size (number basis) of gold particles was 81.2 nm. And the polydispersity index was 〇.292. The measurement by the dynamic light scattering method was carried out at room temperature (25 ^° C). The refractive index of the dispersion medium = 1.33, the refractive index of the sample = 1.46, and the viscosity of the sample (cP) = 0.89. The experimental conditions of

The above aqueous dispersion contains 100 mass ppm of gold, 6.0 mass% of polyvinylpyrrolidone (dispersant, Twe en 80), and 4.5 mass% of 1,2-hexanediol (preservative. ), 150 mass ppm of polyethyleneimine (dispersant), and the balance water. The gold particles were obtained by reducing chloroauric acid (丨丨丨) (HA u CI ₄ ).

<Stability test of gold particles>

The stability of the above aqueous dispersion was confirmed under the conditions shown in Table 1. The evaluation criteria in Table 1 are that after exposing the aqueous dispersion to each of the stability test conditions listed in Table 1,

After storing for 5 days, if the aqueous dispersion can maintain the transparency by visual observation, it is designated as "A", and if the precipitate is visually confirmed, it is designated as "B".

[0044] 〇 2020/175 701 15 卩 (：171? 2020 /008523

[table 1]

* 0.1 I of each additive was added to 5 I of the aqueous dispersion.

<Stability test of gold particles over time>

After storing the above aqueous dispersion at 4 ^° C for 1 year, the average particle diameter and polydispersity index were measured by the same method as described above. The average particle size (number basis) of gold particles is

82. a 5 _n m, a polydispersity index was 〇. 272. The changes in average particle size and polydispersity index after storage were 1.6% and 8.2%, respectively. After storage, the aqueous dispersion maintained transparency.

After storing the above aqueous dispersion at room temperature (25 ^° ◯) for 1 year and 8 months, the average particle size and polydispersity index were measured by the same method as described above. The average particle diameter of the particles (number reference number) is 1 05. 4 _n m, a polydispersity index was 〇. 243. The changes in average particle size and polydispersity index after storage were 29.8% and 20.2%, respectively. The aqueous dispersion after storage maintained transparency.

Claims

\¥02020/175701 16 (: 17 2020 /008523 Claims [Claim 1] Includes gold particles having an average particle size of 200 n 〇! or less, and at least one of the following conditions (1) and (2): Meet the aqueous dispersion. (1) The aqueous dispersion

The change in average particle size of the gold particles after storage is within 30%, and the change in polydispersity index is within 25%. (2) When the aqueous dispersion is stored at 4°C for 1 year, the average particle size change rate of the gold particles after storage is 10% or less, and the polydispersity index change rate is 20% or less. is there. [Claim 2] The aqueous dispersion according to claim 1, wherein the polydispersity index of the gold particles is not less than 0.1. [Claim 3] comprising gold particles having an average particle diameter of 200 n 〇! or less, An aqueous dispersion in which the polydispersity index of the gold particles is not less than 0.1. [Claim 4] Further comprising polyvinylpyrrolidone and polyethyleneimine The aqueous dispersion according to any one of 1 to 3. [Claim 5] A cosmetic composition comprising the aqueous dispersion according to any one of claims 1 to 4. [Claim 6] A method for producing a cosmetic, comprising a step of blending the aqueous dispersion according to any one of claims 1 to 4 with another raw material.