WO2020170476A1 - Hair treatment composition - Google Patents

Abstract

A hair treatment composition that comprises: 0.0005 wt% or more of a melanin synthesis-promoting peptide; 0.00069 wt% or more of a hair-regenerating peptide; 0.00001 wt% or more of an anti-aging peptide; 0.01525 wt% or more of a stem cell lysate; and 0.00563 wt% or more of an anti-inflammatory plant extract.

Description

Hair treatment composition

The present invention relates to a hair treatment composition.

Hair color is formed by melanin pigment. There are two types of melanin: brown to black eumelanin and yellow to red pheomelanin. The abundance ratio of eumelanin and pheomelanin in hair determines the hair color. For example, if eumelanin is high and pheomelanin is low, the hair becomes black. When eumelanin is low and pheomelanin is high, the hair becomes blonde or red. When the melanin pigment contained in the hair decreases or disappears, the hair becomes gray or gray (see, for example, Patent Documents 1 to 3).

Pigmentary stem cells are present in the bulge area of the hair follicle. Pigment stem cells produce pigment cells (melanocytes). Pigment cells produce melanin pigment and supply it to hair matrix cells (keratinocytes). Hair mother cells supplied with melanin pigment divide and grow into hair. Pigment stem cells are considered to decrease with age or decrease in activity. A decrease in pigment stem cells and a decrease in activity are believed to be responsible for gray or gray hair.

Japanese Patent No. 3289975 Japanese Patent No. 4971072 Japanese Patent No. 5850266

One of the objects of the present invention is to provide a hair treatment composition capable of efficiently increasing the melanin pigment of hair.

According to an embodiment of the present invention, 0.0005% by weight or more of melanin synthesis promoting peptide, 0.00069% by weight or more of hair regeneration peptide, 0.00001% by weight or more of anti-aging peptide, and 0.01525% by weight. There is provided a hair treatment composition comprising the above-mentioned stem cell lysate and 0.00563% by weight or more of an anti-inflammatory plant extract.

In the above hair treatment composition, the melanin synthesis promoting peptide may be palmitoyl tetrapeptide-20 or palmitoyl tetrapeptide-20 amide.

In the above hair treatment composition, palmitoyl tetrapeptide-20 amide may be included in Gyberth®.

In the above hair treatment composition, the hair regeneration peptide may be acetyltetrapeptide-3.

In the above hair treatment composition, the hair regeneration peptide may be contained in Capixil (registered trademark).

In the above hair treatment composition, the anti-aging peptide may be trifluoroacetyltripeptide-2.

In the above hair treatment composition, the anti-aging peptide may be included in Progerin (registered trademark).

In the above hair treatment composition, the stem cell lysate may include an apple stem cell lysate.

The above hair treatment composition may contain 0.009% by weight or more of an apple stem cell lysate.

In the above hair treatment composition, the stem cell lysate may include bamboo stem cell lysate.

The above hair treatment composition may contain 0.00625% by weight or more of a bamboo stem cell lysate.

In the above hair treatment composition, the anti-inflammatory plant extract may include a willow lantern extract.

The above hair treatment composition may contain 0.005% by weight or more of the willow lantern extract.

In the above hair treatment composition, Yanagilan extract may be included in Defense Calp (registered trademark).

In the above hair treatment composition, the anti-inflammatory plant extract may include red clover flower extract.

The above hair treatment composition may contain 0.00063% by weight or more of red clover flower extract.

In the above hair treatment composition, Capxil (registered trademark) may contain the red clover flower extract.

The above hair treatment composition may prevent gray or gray hair.

The above hair treatment composition may increase the melanin pigment of the hair.

The above hair treatment composition may be shampoo.

The above hair treatment composition may be a serum.

According to an aspect of the present invention, there is provided a method of preventing gray or gray hair, which comprises applying the above hair treatment composition to the scalp.

According to an aspect of the present invention, there is provided a method of increasing melanin pigment in hair, comprising applying to the scalp the above hair treatment composition.

According to an embodiment of the present invention, 1.0% by weight or more of Grabers®, 2.5% by weight or more of Capxil®, and 0.05% by weight or more of Progelin®. And 0.009 wt% or more of apple stem cell lysate, 0.00625 wt% or more of bamboo stem cell lysate, and 0.1 wt% or more of Defense Scalp (registered trademark), a hair treatment composition Will be provided.

The above hair treatment composition may prevent gray or gray hair.

The above hair treatment composition may increase the melanin pigment of the hair.

The above hair treatment composition may be shampoo.

The above hair treatment composition may be a serum.

According to the present invention, it is possible to provide a hair treatment composition that can efficiently increase the melanin pigment of hair.

It is a graph which shows the transition of the improvement rate ratio of the amount of white hair evaluated by the doctor and the hair diagnostician according to the example. It is a table which shows the transition of the improvement rate of the amount of white hair evaluated by the doctor and the hair diagnostician according to the example. It is a graph which shows the transition of the improvement degree ratio of the color of the white hair evaluated by the doctor and the hair diagnostician according to the example. It is a table which shows the transition of the improvement rate of the color of white hair evaluated by the doctor and the hair diagnostician according to the example. It is a graph which shows the transition of the improvement rate of the root of the white hair evaluated by the doctor and the hair diagnostician according to the example. It is a table which shows the transition of the improvement degree ratio of the root of the white hair evaluated by the doctor and the hair diagnostician according to the example. 6 is a graph and a table showing a change in the degree of anxiety of gray hair according to a questionnaire of test subjects according to an example. It is a graph and a table which show transition of VAS change rate of the degree to which gray hair becomes anxious according to the questionnaire of the subject concerning an example. 3 is a graph and a table showing changes in the amount of gray hair according to a questionnaire of test subjects according to an example. It is a graph and a table which show transition of the VAS change rate of the amount of white hair by the subject's questionnaire concerning an example. It is a graph and a table which show the change of the color of white hair by a questionnaire of a subject concerning an example. 5 is a graph and a table showing changes in the VAS change rate of gray hair color according to a questionnaire of test subjects according to an example. It is a graph and a table which show transition of the range of white hair by a subject's questionnaire concerning an example. It is a graph and a table which show transition of the VAS change rate in the range of gray hair by the subject's questionnaire concerning an example. It is a graph and a table which show transition of the conspicuousness of gray hair by a subject's questionnaire concerning an example. It is a graph and a table which show transition of VAS change rate of the degree of conspicuousness of gray hair by a subject's questionnaire concerning an example. It is a table which shows the diagnostic result of the test subject by the doctor and the hair diagnostician who concern on an Example. It is a graph which shows the transition of the improvement degree ratio of the amount of white hair evaluated by the doctor and the hair diagnostician according to the comparative example. It is a table which shows the transition of the improvement rate of the amount of white hair evaluated by the doctor and the hair diagnostician according to the comparative example. It is a graph which shows the transition of the improvement rate of the color of white hair evaluated by the doctor and the hair diagnostician according to the comparative example. It is a table which shows the transition of the improvement rate of the color of white hair evaluated by the doctor and the hair diagnostician according to the comparative example. It is a graph which shows the transition of the improvement degree ratio of the root of the white hair evaluated by the doctor and the hair diagnostician according to the comparative example. It is a table which shows the transition of the improvement rate of the root of the white hair evaluated by the doctor and the hair diagnostician according to the comparative example.

Hereinafter, embodiments of the present invention will be described in detail. The embodiments described below exemplify devices and methods for embodying the technical idea of the present invention, and the technical idea of the present invention specifies combinations of constituent members and the like as follows. Not a thing. The technical idea of the present invention can be modified in various ways within the scope of the claims.

The hair treatment composition according to the embodiment has 0.0005% by weight or more of melanin synthesis promoting peptide, 0.00069% by weight or more of hair regeneration peptide, 0.00001% by weight or more of anti-aging peptide, and 0.01525. Includes at least wt% stem cell lysate and at least 0.00563 wt% anti-inflammatory plant extract.

The concentration of the melanin synthesis promoting peptide in the hair treatment composition according to the embodiment may be 0.0005% by weight or more, 0.00065% by weight or more, or 0.0008% by weight or more. Further, the concentration of the melanin synthesis promoting peptide may be 0.0025% by weight or less, 0.002% by weight or less, or 0.0015% by weight or less. The melanin synthesis promoting peptide promotes the synthesis of melanin pigment. The melanin synthesis promoting peptide binds to, for example, melanocortin 1 receptor (MC1-R). In addition, the melanin synthesis promoting peptide may reduce oxidative stress of melanin pigment that causes gray hair or gray hair. For example, a melanin synthesis promoting peptide may activate the longevity protein sirtuin (SIRT) and the antioxidant enzyme tyrosine kinase-related protein (TRP)-2.

Examples of melanin synthesis promoting peptides include palmitoyl tetrapeptide-20, palmitoyl tetrapeptide-20 amide, and acetyl hexapeptide-1. Palmitoyl tetrapeptide-20 is the reaction product of palmitic acid and a synthetic tetrapeptide consisting of arginine, histidine, phenylalanine and tryptophan. Palmitoyl tetrapeptide-20 is a biomimetic peptide of α-melanocyte stimulating hormone (MSH). Palmitoyl tetrapeptide-20 amide may be included in Graverse (registered trademark, AH&NS).

The concentration of Grayverse (registered trademark, AH&NS) in the hair treatment composition according to the embodiment may be 1.0% by weight or more, 1.25% by weight or more, or 1.5% by weight or more. Further, the concentration of GRAVERS (registered trademark, AH&NS) may be 6.0% by weight or less, 5.5% by weight or less, or 5.0% by weight or less.

The concentration of the hair regeneration peptide in the hair treatment composition according to the embodiment may be 0.00069% by weight or more, 0.0009% by weight or more, or 0.0011% by weight or more. The concentration of the hair-regenerating peptide may be 0.00345% by weight or less, 0.00276% by weight or less, or 0.00207% by weight or less. The hair regeneration peptide may be a peptide that protects hair follicles and hair roots. In addition, the hair-regenerating peptide may have an anti-inflammatory effect that suppresses inflammation that causes gray hair or gray hair. The hair regeneration peptide may be a peptide that suppresses 5α reductase and suppresses androgen.

Examples of hair regeneration peptides include acetyl tetrapeptide-3 and tripeptide-1 copper. Acetyltetrapeptide-3 is obtained by acetylating a synthetic tetrapeptide containing lysine, glycine, histidine, and lysine. Acetyl tetrapeptide-3 may be contained in Capixil (registered trademark, AH&NS).

The concentration of capxil (registered trademark, AH&NS) in the hair treatment composition according to the embodiment may be 2.5% by weight or more, 3.125% by weight or more, or 3.75% by weight or more. Further, the concentration of Capxil (registered trademark, AH&NS) may be 15.0% by weight or less, 13.75% by weight or less, or 12.5% by weight or less.

The concentration of the anti-aging peptide in the hair treatment composition according to the embodiment may be 0.00001% by weight or more, 0.00001% by weight or more, or 0.00002% by weight or more. Further, the concentration of the anti-aging peptide may be 0.00005% by weight or less, 0.00004% by weight or less, or 0.00003% by weight or less. The anti-aging peptide improves resistance to stress hormones in hair follicle cells and hair papilla cells, for example. The anti-aging peptide may have a function of suppressing inflammation that causes gray hair or gray hair. The presence of hair regrowth peptides and anti-aging peptides tends to suppress neutrophil elastase and protect hair follicles against stress hormones.

An example of an anti-aging peptide is trifluoroacetyltripeptide-2. Trifluoroacetyltripeptide-2 is obtained from tripeptide-2 containing valine, tyrosine and valine, and trifluoroacetic acid. Trifluoroacetyltripeptide-2 may be contained in Progeline (registered trademark, AH&NS).

The concentration of progerin (registered trademark, AH&NS) in the hair treatment composition according to the embodiment may be 0.05% by weight or more, 0.0625% by weight or more, or 0.075% by weight or more. Further, the concentration of progerin (registered trademark, AH&NS) may be 0.3% by weight or less, 0.275% by weight or less, or 0.25% by weight or less.

The concentration of the stem cell lysate in the hair treatment composition according to the embodiment may be 0.01525% by weight or more, 0.01976% by weight or more, or 0.02432% by weight or more. Further, the concentration of the stem cell lysate may be 0.076% by weight or less, 0.061% by weight or less, or 0.0456% by weight or less. The stem cell lysate may be an extract of stem cells. Stem cell lysates include at least lysates of stem cell cytoplasmic components. The stem cell lysate may include a lysate of stem cell cell wall components in addition to a lysate of stem cell cytoplasmic components.

The stem cell lysate may include apple stem cell lysate. The apple stem cell lysate may be an apple stem cell extract. Apple stem cells have the effect of maintaining melanin pigment in the hair root. The apple stem cell lysate comprises at least a lysate of apple stem cell cytoplasmic components. The apple stem cell lysate may contain a lysate of apple stem cell cell wall components in addition to a lysate of apple stem cell cytoplasmic components. Apple stem cell lysates protect, for example, the scalp, hair follicles, and activate bulge stem cells. The presence of the hair regeneration peptide and the apple stem cell lysate tends to improve the hair root protecting action and the collagen 17 production promoting action. The method for producing an apple stem cell lysate is arbitrary, but for example, apple stem cell lysate may be obtained by applying high pressure to apple stem cells. The apple stem cell lysate may be contained in a solvent containing lecithin, glycerin, xanthan gum, and phenoxyethanol.

The concentration of the apple stem cell lysate in the hair treatment composition according to the embodiment may be 0.009% by weight or more, 0.0117% by weight or more, or 0.0144% by weight or more. The concentration of apple stem cell lysate may be 0.045% by weight or less, 0.036% by weight or less, or 0.027% by weight or less. As the apple stem cell lysate, for example, PhytoCellTec Malus Domestica (registered trademark, AH&NS) can be used.

The stem cell lysate may include bamboo stem cell lysate. The bamboo stem cell lysate may be an extract of bamboo stem cells. As bamboo stem cells, Moso bamboo growing point stem cells can be used. The bamboo stem cell lysate contains at least a lysate of cytosolic components of bamboo stem cells. The bamboo stem cell lysate may contain a lysate of a bamboo stem cell cell wall component in addition to a lysate of a bamboo stem cell cytoplasmic component. The method for producing a bamboo stem cell lysate is arbitrary, but for example, a cytosolic aqueous solution of bamboo stem cells may be extracted.

The concentration of the bamboo stem cell lysate in the hair treatment composition according to the embodiment may be 0.00625% by weight or more, 0.00813% by weight or more, or 0.01% by weight or more. The concentration of the bamboo stem cell lysate may be 0.03125% by weight or less, 0.025% by weight or less, or 0.01875% by weight or less. The bamboo stem cell lysate has, for example, an anti-glycation activity, promotes collagen production, and induces keratin. When the scalp is saccharified, the scalp tends to become hard. The presence of bamboo stem cell lysate, hair regeneration peptide, and apple stem cell lysate tends to improve the anti-glycation action and keratin-inducing action. Bamboo stem cell lysates are available, for example, from AH&NS.

The concentration of the anti-inflammatory plant extract in the hair treatment composition according to the embodiment may be 0.00563% by weight or more, 0.00732% by weight or more, or 0.00901% by weight or more. The concentration of the anti-inflammatory plant extract may be 0.02815% by weight or less, 0.02252% by weight or less, or 0.01689% by weight or less. The anti-inflammatory plant extract may have a function of protecting hair roots. The presence of the hair regeneration peptide and the anti-inflammatory plant extract tends to improve the anti-inflammatory effect and the hair root protecting effect.

Examples of anti-inflammatory plant extracts include willowlan extract. The willow extract may be an extract of willow flowers, an extract of leaves of willow leaves, and an extract of willow leaves, and mixtures thereof. The willow radix extract maintains the amount of Malassezia bacterium, which is an indigenous scalp bacterium, in an appropriate state and protects hair roots. The willow radish extract contains oenothein B represented by the following chemical formula as an active ingredient.

The concentration of the willow radix extract in the hair treatment composition according to the embodiment may be 0.005% by weight or more, 0.0065% by weight or more, or 0.008% by weight or more. Further, the concentration of the willow radix extract in the hair treatment composition according to the embodiment may be 0.025% by weight or less, 0.02% by weight or less, or 0.015% by weight or less. The willow orchid extract may be contained in Defense Scalp (registered trademark, AH&NS).

The concentration of defense scalp (registered trademark, AH&NS) in the hair treatment composition according to the embodiment may be 0.1% by weight or more, 0.125% by weight or more, or 0.15% by weight or more. The concentration of Defense Scalp (registered trademark, AH&NS) may be 0.6% by weight or less, 0.55% by weight or less, or 0.5% by weight or less.

Examples of anti-inflammatory plant extracts include red clover flower extract and avocado oil fatty acid butyl. In the hair treatment composition according to the embodiment, it is preferable that the flower regeneration peptide and red clover flower extract or avocado oil fatty acid butyl are blended. Red clover has the effect of inhibiting interleukin-8, which can damage dermal papilla cells. Red clover also contains biochanin A represented by the following chemical formula.

The concentration of red clover flower extract in the hair treatment composition according to the embodiment may be 0.00063% by weight or more, 0.00082% by weight or more, or 0.001% by weight or more. The concentration of red clover flower extract may be 0.00315% by weight or less, 0.00232% by weight or less, and 0.00189% by weight or less. The red clover flower extract may be contained in Capixil (registered trademark, AH&NS) or minipolyl (registered trademark, AH&NS).

The hair treatment composition according to the embodiment may be shampoo, beauty essence, hair rinse, gel, hair treatment, lotion, tincture, spray, mousse, cleaning composition, hair conditioner, tonic, pomade, foam and the like. The hair treatment composition according to the embodiment is applied to the scalp, for example, once or more per day.

The hair treatment composition according to the embodiment is, for example, water, a water-soluble organic solvent such as a C1-C4-alkanol, an oil, a fatty substance, a wax, a C6-C30 monocarboxylic acid, and a monovalent, divalent or trivalent. Esters with alcohols, saturated acyclic and cyclic hydrocarbons, fatty acids, aliphatic alcohols, silicone oils, surface-active ingredients, defoamers, propellants, defoamers, emulsifiers, foaming agents and solubilizers. May be included. The surface-active component may be anionic, cationic, amphoteric and neutral. The emulsifier may be anionic, cationic, amphoteric and neutral.

The hair treatment composition according to the embodiment may include, for example, a water-soluble or water-dispersible hair polymer. Examples of hair polymers include hair styling polymers and conditioning polymers. More specifically, examples of hair polymers include copolymers of vinyl acetate and crotonic acid, copolymers of methyl vinyl ether and maleic anhydride, copolymers of acrylic acid or methacrylic acid and other monomers, polyurethane, N-vinylpyrrolidone, and Silicone polymers may be mentioned.

The hair treatment composition according to the embodiment may include a water-insoluble silicone such as polydimethylsiloxane. The hair treatment composition according to the embodiment may include a wax such as fatty acid amide.

The hair treatment composition according to the embodiment may include, for example, an antioxidant. The willow orchid extract and red clover flower extract described above may also function as antioxidants. Examples of other antioxidants include hematin, vitamin C, and vitamin E.

The hair treatment composition according to the embodiment may include, for example, a preservative, an antioxidant, a perfume oil, a lipid re-fatification agent, an active ingredient, and a care ingredient. For example, the hair treatment composition according to the embodiment includes panthenol, collagen, vitamins, protein hydrolyzate, α and β hydroxyl carbonic acid, a stabilizer, a pH adjuster, an opacifying agent, a coloring agent, a dye, a gel forming agent. , Salts, humectants, complexing agents, viscosity modifiers, and light screening agents.

Hair treatment compositions according to embodiments may also include, for example, polyalkyl siloxanes, polyaryl siloxanes, polyarylalkyl siloxanes, silicone resins, polyether siloxanes, dimethicone copolyols (CTFA), and amino-functionalized silicone compounds. Good.

When the hair treatment composition according to the embodiment includes a propellant, the hair treatment composition according to the embodiment includes, for example, propane/butane, pentane, dimethyl ether, 1,1-difluoroethane (HFC-152a), carbon dioxide, nitrogen. , And a mixture of compressed air.

When the hair treatment composition according to the embodiment contains a nonionic emulsifier, the hair treatment composition according to the embodiment includes, for example, laureth such as laureth-4, ceteth such as ceteth-1, polyethylene glycol cetyl ether, ceteareth- Ceteareths such as 25, polyglycol fatty acid glycerides, hydroxylated lecithin, lactyl esters of fatty acids, and alkyl polyglycosides.

When the hair treatment composition according to the embodiment contains a nonionic surfactant, the hair treatment composition according to the embodiment has, for example, an aliphatic group having a linear or branched alkyl chain of 6 to 20 carbon atoms. It may contain a reaction product of an alcohol or an alkylphenol and ethylene oxide and/or propylene oxide.

Hair treatment compositions according to embodiments may include, for example, alkyl amine oxides, mono- or dialkyl alkanolamides, polyethylene glycol fatty acid esters, alkyl polyglycosides, and sorbitan esters.

When the hair treatment composition according to the embodiment contains a cationic emulsifier and/or a cationic surfactant, the hair treatment composition according to the embodiment may contain, for example, a quaternized ammonium compound. Hair treatment compositions according to embodiments include, for example, cetyltrimethylammonium chloride or bromide, stearylbenzyldimethylammonium chloride, distearyldimethylammonium chloride, stearamidopropyldimethylamine, hydroxyethylcetyldimonium phosphate, poly(oxy-1, 2-ethanediyl), and (octadecylnitrilo)tri-2,1-ethanediyl)tris-(hydroxy)-phosphate. Hair treatment compositions according to embodiments may include a cationic guar derivative such as, for example, guar hydroxypropyltrimonium chloride.

When the hair treatment composition according to the embodiment includes an anionic emulsifier and/or an anionic surfactant, the hair treatment composition according to the embodiment includes, for example, alkyl sulfate, alkyl ether sulfate, alkyl sulfonate, alkyl aryl sulfonate, It may include alkyl succinates, alkyl sulfosuccinates, N-alkyl sarcosinates, acyl taurates, acyl isethionates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, and α-olefin sulfonates. ..

When the hair treatment composition according to the embodiment includes an anionic surfactant, the hair treatment composition according to the embodiment includes, for example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl ether sulfate, and lauroyl sarconisate. It may include sodium, sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate, and triethanolamide decyl benzene sulfonate.

When the hair treatment composition according to the embodiment contains an amphoteric surfactant, the hair treatment composition according to the embodiment includes, for example, alkylbetaine, alkylamidopropylbetaine, alkylsulfobetaine, alkylglycinate, alkylcarboxyglycinate, It may contain alkylamphoacetates or propionates, as well as alkylamphodiacetates or dipropionates.

The hair treatment composition according to the embodiment can increase melanin pigment in hair and prevent gray hair or gray hair. The hair treatment composition according to the embodiment is capable of returning the color of the hair to the color before becoming gray hair or gray hair.

Although not wishing to be bound by theory, by applying the hair treatment composition according to the embodiment to the scalp, the melanin synthesis promoting peptide promotes the synthesis of melanin pigment in the hair follicle. Even if the synthesis of melanin pigment is promoted, gray or gray hair cannot be effectively returned to hair containing melanin pigment unless strong and thick hair is grown. In contrast, the hair regrowth peptide and the lysate of stem cells promote the thickening and growing of hair containing melanin pigment. Furthermore, the anti-aging peptide improves the resistance of hair follicle cells and hair papilla cells to stress hormones, and the anti-inflammatory plant extract suppresses inflammation in the hair follicles, so that gray hair or gray hair becomes hair containing melanin pigment. It can be effectively returned.

Although the present invention has been described by way of the embodiments as described above, it should not be understood that the description and drawings forming a part of this disclosure limit the present invention. From this disclosure, various alternative embodiments, examples, and operation techniques should be apparent to those skilled in the art. It should be understood that the present invention covers various embodiments and the like not described herein.

(Example)

0.001% by weight palmitoyl tetrapeptide-20, 0.00138% by weight acetyltetrapeptide-3, 0.00125% by weight red clover flower extract, 0.00002% by weight trifluoroacetyltripeptide-2, 0. Prepare an essence (beauty essence) according to an example containing 018% by weight of apple fruit culture stem cell extract, 0.0125% by weight of Moso bamboo growth point stem cell lysate, and 0.01% by weight of willow orchid flower/leaf/stem extract. did.

Palmitoyl tetrapeptide-20 was included in Graverse (registered trademark). The content of Glover's (registered trademark) in the essence according to the example was 2.0% by weight. Acetyltetrapeptide-3 and red clover flower extract were included in Capixil®. The content of Capxil (registered trademark) in the essence according to the example was 5.0% by weight. Trifluoroacetyltripeptide-2 was included in Progerin®. The content of Progerin (registered trademark) in the essence according to the example was 0.1% by weight. Apple fruit culture stem cell extract and Moso mesophyll stem cell lysate were purchased from AH&NS. Willow flower/leaf/stem extract was included in Defense Scalp®. The content of Defense Scalp (registered trademark) in the essence according to the example was 0.2% by weight.

20 adults aged 20 to 69 (average age 43) were selected as subjects. Before the test subject started using the essence according to the example, the doctor and the hair diagnostician observed the gray hair of the test subject's crown and temporal region. In addition, a doctor and a hair diagnostician observed the hair color at the base of the subject's temporal region (hairline at the top of the earring) using a microscope.

After that, the test subject washed the hair with shampoo containing an antioxidant once a day for 3 months, and applied the essence according to the example to the entire scalp. Meanwhile, the subject was prohibited from using other shampoos, hair cosmetics, gray hair dyes, hair colors, and the like. At 1st month, 2nd month, and 3rd month after starting to use the essence according to the example, the doctor and the hair diagnostician observed the hair of the test subject. Two months after starting to use the essence according to the example, one subject was excluded from the subject due to personal circumstances.

1 and 2 show changes in the proportion of improvement in the amount of gray hair of the subject, as observed by doctors and hair diagnosticians. When the amount of gray hair decreased, it was evaluated as improvement. Regarding the amount of gray hair on the parietal region, one month after the start of use compared with the amount before use, “invariant” was 8 out of 20 (40%), “slightly improved” was 5 out of 20 (25%), “Improvement” was 7 out of 20 (35%). Regarding the amount of gray hair on the parietal region, 2 months after the start of use, compared to before use, "immutable" was 5 out of 20 (25%), "slightly improved" was 10 out of 20 (50%), The “improvement” was 5 out of 20 (25%). Regarding the amount of gray hair on the parietal region, 3 months after the start of use, "slight improvement" was observed in 8 out of 19 (42%) and "improvement" was found in 11 out of 19 (58%). there were.

Regarding the amount of gray hair on the side of the head, 8 months out of 20 (40%) "immutable" and 5 out of 20 (25%) "invariant" compared to before use , “Improvement” was 7 out of 20 (35%). Regarding the amount of gray hair on the side of the head, 1 month out of 20 (5%) and 16 cases out of 20 (80%) were "unchanged" at 2 months after the start of use compared to before use. , “Improvement” was 3 out of 20 (15%). Regarding the amount of gray hair on the side of the head, “slightly improved” was 10 out of 19 (53%), and “improved” was 9 out of 19 (47%) three months after the start of use, compared to before use. Met.

3 and 4 show changes in the proportion of improvement in the color of the subject's gray hair observed by doctors and hair diagnosticians. When the white hair was colored, it was evaluated as improved. About the color of the gray hair on the top of the head, 1 month after the start of use, compared to before use, “invariant” was 8 out of 20 (40%), “slightly improved” was 7 out of 20 (35%), The “improvement” was 5 out of 20 (25%). About the color of the gray hair on the top of the head, 2 months after the start of use, compared to before use, “invariant” was 2 out of 20 (10%), “slightly improved” was 15 out of 20 (75%), The “improvement” was 3 out of 20 (15%). Regarding the color of the gray hair on the top of the head, 3 months after the start of use, “slight improvement” was observed in 10 out of 19 (53%), and “improvement” was observed in 9 out of 19 (47%). there were.

About the color of the gray hair on the side of the head, one month after the start of use, 8 times (40%) were "unchanged" and 9 out of 20 people (45%) were "slightly improved" compared to before use. , “Improvement” was 3 out of 20 (15%). Regarding the color of the gray hair on the side of the head, 1 month out of 20 (5%) and 17 cases out of 20 (85%) were "unchanged" two months after the start of use compared to before use. , “Improvement” was 2 out of 20 (10%). Regarding the color of the white hair on the side of the head, after 3 months from the start of use, "slightly improved" was 13 out of 19 (68%), and "improved" was 6 out of 19 (32%). Met.

Fig. 5 and Fig. 6 show changes in the improvement rate of the roots of the gray hairs of the subjects as observed by doctors and hair diagnosticians. In addition, when the root of the gray hair turned gray, it was evaluated as improvement. Regarding the condition of the roots of the gray hair on the top of the head, 1 month after the start of use, 8 times (40%) were "unchanged" and 5 out of 20 (25% were "improved" compared to before use. ), and “improvement” was 7 out of 20 (35%). Regarding the condition of the roots of the gray hair on the crown, 3 months out of 20 (15%) and 14% out of 20 (70%) were "unchanged" two months after the start of use compared to before use. ), and “improvement” was 3 out of 20 (15%). Regarding the condition of the roots of the gray hair on the top of the crown, 10% (19%) out of 19 (19%) and 19% (47%) were "improved" after 3 months from the start of use. )Met.

Regarding the state of the roots of the white hair on the temporal side, 9 months out of 20 (45%) "immutable" and 5 out of 20 (25%) %), “improvement” was 6 out of 20 (30%). Regarding the condition of the roots of the white hair on the temporal side, 1 month out of 20 (5%) and 11% out of 20 (55%) were "unchanged" two months after the start of use compared to before use. %) and “improvement” were 8 out of 20 (40%). Regarding the state of the base of the gray hair on the side of the head, “slightly improved” was 8 out of 19 (42%) and “improved” was 11 out of 19 (58%) 3 months after the start of use as compared with before use. %)Met.

A questionnaire was conducted on the subjects regarding the degree of gray hair anxiety using a visual analog scale (VAS). In VAS, the evaluation value when the gray hair was a concern was 0, and the evaluation value when the gray hair was not a concern was 10. As a result, as shown in FIG. 7, it was shown that gray hair became less of a concern after starting to use the essence according to the example. Further, the change rate (%) of VAS means improvement when it is larger than 105%, and means deterioration when it is smaller than 95%. As shown in FIG. 8, it was shown that since the use of the essence according to the example was started, the degree of anxiety about gray hair was improved.

A questionnaire using VAS was conducted on the subjects regarding the amount of gray hair. In VAS, the evaluation value when the amount of white hair increased was 0, and the evaluation value when the amount of white hair decreased was 10. As a result, as shown in FIG. 9, it was shown that the amount of gray hair decreased after the use of the essence according to the example was started. In addition, as shown in FIG. 10, it was shown that the amount of white hair has been improved since the use of the essence according to the example was started.

A questionnaire was conducted on the subjects regarding the color of gray hair using VAS. In VAS, the evaluation value when the color of white hair became light was 0, and the evaluation value when the color of white hair became dark was 10. As a result, as shown in FIG. 11, it was shown that the white hair became darker in color after the use of the essence according to the example was started. In addition, as shown in FIG. 12, it was shown that the improvement of the color of white hair has progressed since the use of the essence according to the example was started.

A questionnaire using VAS was conducted on the subjects regarding the range of gray hair. In VAS, the evaluation value when the range of white hair increased was 0, and the evaluation value when the range of white hair decreased was 10. As a result, as shown in FIG. 13, it was shown that the range of gray hair was reduced after the use of the essence according to the example was started. In addition, as shown in FIG. 14, it was shown that the improvement of the range of gray hair has progressed since the use of the essence according to the example was started.

A questionnaire using VAS was conducted on the subjects regarding how noticeable their gray hair was. In VAS, the evaluation value when the white hair became noticeable was 0, and the evaluation value when the white hair became less noticeable was 10. As a result, as shown in FIG. 15, it was shown that white hair became less noticeable after the use of the essence according to the example was started. In addition, as shown in FIG. 16, it was shown that the improvement in the conspicuousness of the gray hair proceeded after the use of the essence according to the example was started.

・The doctor confirmed to the test subject that the scalp was itchy and the scalp was abnormal at the test site. As a result, as shown in FIG. 17, no scalp condition was observed.

(Comparative example)
Includes 0.001% by weight of palmitoyl tetrapeptide-20, but acetyltetrapeptide-3, red clover flower extract, trifluoroacetyltripeptide-2, apple fruit culture stem cell extract, moss shoot meristem stem cell lysate, and willow flower/ An essence (beauty essence) according to a comparative example, which is the essence according to the comparative example not containing the leaf/stem extract and the other composition is the same as the essence according to the example, was prepared.

20 adults aged 20 to 69 (average age 44) were selected as subjects. Before the test subject started to use the essence according to the comparative example, the doctor and the hair diagnostician observed the gray hair of the test subject's crown and temporal region. In addition, a doctor and a hair diagnostician observed the hair color at the base of the subject's temporal region (hairline at the top of the earring) using a microscope.

After that, the test subjects (one was excluded from the test due to personal reasons of the test subjects) washed their hair with shampoo containing an antioxidant once a day for 3 months to give the essence according to the comparative example. Applied to the entire scalp. Meanwhile, the subject was prohibited from using other shampoos, hair cosmetics, gray hair dyes, hair colors, and the like. At 1st month, 2nd month, and 3rd month after starting to use the essence according to the comparative example, the doctor and the hair diagnostician observed the hair of the test subject.

18 and 19 show changes in the proportion of improvement in the amount of gray hair of the test subject as observed by doctors and hair diagnosticians. The observation criteria were the same as in the example. Regarding the amount of gray hair on the parietal area, 6 months out of 19 (31%), "slightly improved" was 10 out of 19 (53%) after 1 month of use compared to before use. “Improved” was 3 out of 19 (16%). Regarding the amount of gray hair on the top of the crown, 6 months out of 19 (32%) and 12% out of 19 (63%) were "unchanged" at 2 months after the start of use as compared with before use. The “improvement” was 1 out of 19 (5%). Regarding the amount of gray hair on the top of the head, 13% (19%) out of 19 (6%) out of 19 (6%/32%) "improved" after 3 months of use compared to before use there were.

Therefore, when the essence according to the comparative example was used, the degree of improvement in the amount of gray hair on the parietal region was lower than when the essence according to the example was used.

Regarding the amount of gray hair on the temporal side, 7 months out of 19 (37%) and 11% out of 19 (58%) were "unchanged" one month after the start of use compared to before use. , “Improvement” was 1 out of 19 (5%). Regarding the amount of gray hair on the side of the head, 3 months out of 19 (16%) and “slightly improved” 15 out of 19 (79%) after 2 months of use compared to before use , “Improvement” was 1 out of 19 (5%). Regarding the amount of gray hair on the side of the head, 16% out of 19 (84%) "improved" and 3 out of 19 (16%) after 3 months of use compared to before use Met.

Therefore, when the essence according to the comparative example was used, the degree of improvement in the amount of white hair on the temporal region was lower than when the essence according to the example was used.

20 and 21 show changes in the rate of improvement in the color of the subject's gray hair observed by doctors and hair diagnosticians. The observation criteria were the same as in the example. Regarding the color of the gray hair on the top of the crown, one month after the start of use as compared with that before use, "immutable" was 8 out of 19 (42%), "slightly improved" was 9 out of 19 (47%), “Improved” was 2 out of 19 (11%). Regarding the color of the gray hair on the top of the head, 5 months out of 19 (26%), “slightly improved” was 12 out of 19 (63%), 2 months after the start of use, compared to before use. “Improved” was 2 out of 19 (11%). Regarding the color of the gray hair on the top of the crown, 12% (19%) out of 19 (7% out of 19) showed "slight improvement" at 3 months after the start of use, compared with 3 months after the start of use. there were.

Therefore, when the essence according to the comparative example was used, the degree of improvement in the color of the white hair on the parietal region was lower than when the essence according to the example was used.

About the color of the gray hair on the side of the head, one month after the start of use compared to before use, “unchanged” was 8 out of 19 (42%), and “slightly improved” was 11 out of 19 (58%). Met. About the color of gray hair on the side of the head, 4 months out of 19 (21%) and “slightly improved” 15 out of 19 (79%) two months after the start of use compared to before use Met. About the color of white hair on the side of the head, 3 months after the start of use compared to before use, "unchanged" was 1 out of 19 (5%) and "slightly improved" was 14 out of 19 (74%) , “Improvement” was 4 out of 19 (21%).

Therefore, when the essence according to the comparative example was used, the degree of improvement in the color of the white hair on the temporal region was lower than when the essence according to the example was used.

22 and 23 show changes in the percentage of improvement in the roots of the gray hairs of the subjects, as observed by doctors and hair diagnosticians. The observation criteria were the same as in the example. Regarding the condition of the roots of the gray hair on the crown, 8 months out of 19 (42%) and 11% out of 19 (58%) were "unchanged" one month after the start of use compared to before use. )Met. Regarding the condition of the roots of the gray hair on the top of the head, 8 months out of 19 (42%) and "slightly improved" 11 out of 19 (58%) two months after the start of use compared to before use. )Met. Regarding the condition of the roots of the gray hair on the top of the head, 3 times after the start of use compared to before use, "immutable" was 1 out of 19 (5%) and "slightly improved" was 13 out of 19 (69% ), and “improvement” was 5 out of 19 (26%).

Therefore, when the essence according to the comparative example was used, the degree of improvement of the root of the gray hair on the parietal region was lower than that when the essence according to the example was used.

Regarding the state of the roots of the white hair on the temporal region, 1 month after the start of use, compared to before use, “unchanged” was 8 out of 19 (42%) and “slightly improved” was 9 out of 19 (47). %) and “improvement” were 2 out of 19 (11%). Regarding the state of the base of the white hair on the temporal region, 3 months out of 19 (16%) and 10% out of 19 (53 %) and “improvement” were 6 out of 19 (31%). Regarding the condition of the roots of the white hair on the temporal region, “slightly improved” was 10 out of 19 (53%), and “improved” was 9 out of 19 (47) three months after the start of use compared with before use. %)Met.

Therefore, when the essence according to the comparative example was used, the degree of improvement in the root of the white hair on the temporal region was lower than that when the essence according to the example was used.

Claims (26)

0.0005% by weight or more of a melanin synthesis promoting peptide,
0.00069% by weight or more of hair regeneration peptide,
0.00001% by weight or more of anti-aging peptide,
0.01525 wt% or more of stem cell lysate,
0.00563% by weight or more of an anti-inflammatory plant extract,
A hair treatment composition comprising. The composition according to claim 1, wherein the melanin synthesis promoting peptide is palmitoyl tetrapeptide-20 or palmitoyl tetrapeptide-20 amide. The composition according to claim 2, wherein the palmitoyl tetrapeptide-20 amide is contained in Glover's®. The composition according to any one of claims 1 to 3, wherein the hair regeneration peptide is acetyltetrapeptide-3. The composition according to any one of claims 1 to 4, wherein the hair regeneration peptide is contained in Capixil (registered trademark). The composition according to any one of claims 1 to 5, wherein the anti-aging peptide is trifluoroacetyltripeptide-2. The composition according to any one of claims 1 to 6, wherein the anti-aging peptide is contained in Progerin (registered trademark). The composition according to any one of claims 1 to 7, wherein the stem cell lysate comprises an apple stem cell lysate. The composition according to claim 8, comprising 0.009% by weight or more of the apple stem cell lysate. The composition according to any one of claims 1 to 9, wherein the stem cell lysate comprises bamboo stem cell lysate. The composition according to claim 10, comprising 0.00625% by weight or more of the bamboo stem cell lysate. The composition according to any one of claims 1 to 11, wherein the anti-inflammatory plant extract comprises willow extract. The composition according to claim 12, comprising 0.005% by weight or more of the Salix radix extract. The composition according to claim 12 or 13, wherein the willow orchid extract is contained in Defense Calp (registered trademark). The composition according to any one of claims 1 to 14, wherein the anti-inflammatory plant extract comprises red clover flower extract. The composition according to claim 15, comprising 0.00063% by weight or more of the red clover flower extract. The composition according to claim 15 or 16, wherein the red clover flower extract is contained in Capxil (registered trademark). The composition according to any one of claims 1 to 17, which prevents gray hair or gray hair. The composition according to any one of claims 1 to 18, which increases melanin pigment in hair. The composition according to any one of claims 1 to 19, which is a shampoo. The composition according to any one of claims 1 to 19, which is a serum. Gravers (registered trademark) of 1.0% by weight or more,
2.5% by weight or more of Capxil (registered trademark),
0.05% by weight or more of Progerin (registered trademark),
0.009% by weight or more of apple stem cell lysate,
0.00625% by weight or more of bamboo stem cell lysate,
Defense Scalp (registered trademark) of 0.1% by weight or more,
A hair treatment composition comprising. The composition according to claim 22, which prevents gray hair or gray hair. The composition according to claim 22 or 23, which increases melanin pigment in hair. The composition according to any one of claims 22 to 24, which is a shampoo. The composition according to any one of claims 22 to 24, which is a serum.

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