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WO2020049585A1 - Fps efficace et sûr, non nanométrique et non revêtu - Google Patents

Fps efficace et sûr, non nanométrique et non revêtu Download PDF

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Publication number
WO2020049585A1
WO2020049585A1 PCT/IN2019/050553 IN2019050553W WO2020049585A1 WO 2020049585 A1 WO2020049585 A1 WO 2020049585A1 IN 2019050553 W IN2019050553 W IN 2019050553W WO 2020049585 A1 WO2020049585 A1 WO 2020049585A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
spf
nano
titanium dioxide
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2019/050553
Other languages
English (en)
Inventor
Dhirubhai DESAI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koel Colours Pvt Ltd
Original Assignee
Koel Colours Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koel Colours Pvt Ltd filed Critical Koel Colours Pvt Ltd
Publication of WO2020049585A1 publication Critical patent/WO2020049585A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the present invention relates to an efficient and safe non-nano and non-coated SPF.
  • UV light is just a higher energy version of the light which damages our cells and tissues.
  • UV-A 320 to 400 nm
  • UV-A 320 to 400 nm
  • UV-B (290 to 320 nm) rays have slightly more energy than UVA rays. They can damage skin cells’ DNA directly, and are the main rays that cause sunburns; and
  • UV-C (200 to 290 nm) rays have more energy than the other types of UV rays, but UV-C is absorbed by the ozone layer and does not reach the earth.
  • both UV- A and UV-B can penetrate the atmosphere and exposure to them for short period can cause reddening and irritation of the skin.
  • prolonged exposure can lead to sunburn, premature skin aging, hair damage (including cataracts), melanoma and other skin cancers. Therefore, it is important to have protection from UV-A and UV-B radiation as a part of personal health care.
  • the sun protection factor (SPF rating, introduced in 1974) is a measure of the fraction of sunburn-producing UV rays that reach the skin.
  • the SPF is an imperfect measure of skin damage because invisible damage and skin aging are also caused by ultraviolet type A (UVA, wavelengths 315-400 or 320-400 nm), which does not primarily cause reddening or pain.
  • UVA ultraviolet type A
  • Conventional sunscreen blocks very little UVA radiation relative to the nominal SPF; broad- spectrum sunscreens are designed to protect against both UVB and UVA.
  • UVA also causes DNA damage to cells deep within the skin, increasing the risk of malignant melanomas.
  • Titanium dioxide probably gives good protection, but does not completely cover the UVA spectrum, as early 2000s research suggests that zinc oxide is superior to titanium dioxide at wavelengths 340-380 nm.
  • zinc oxide and titanium dioxide used in the manufacture of SPF are of nano sizes, and are popular in sunscreens and provide sheer sun protection. They are also coated with UV filters like different metal oxides or organic materials like silanes, silicones, organic titanates, fatty acids, metal soaps, polyols, dimethicones, and combinations thereof.
  • Ti0 2 nano particles are normally surface coated with silica, alumina and/or various polymers to (a) increase its stability in the lotion or cream and (b) reduce its photo -activity
  • silica, alumina and/or various polymers to (a) increase its stability in the lotion or cream and (b) reduce its photo -activity
  • a nano particle is a particle of size smaller than 100 nanometers, or 100 billionths of a meter. Defining whether a powder is non-nano or not is actually rather difficult as it is virtually impossible to ensure that a product is 100% nano particle free. Furthermore, many particles are not spherical in shape and thus are difficult to measure.
  • anatase titanium dioxide i.e. more than 90 percent of the particles extracted from the products were nano particles.
  • the nano particles of the anatase titanium dioxide have large relative surface area, and are much more reactive than larger particles of the chemical.
  • the studies have shown that the anatase form of titanium dioxide (and in particular nano-scale anatase titanium dioxide) can increase the formation of free radicals when exposed to sunlight and water and a number of scientists have questioned the safety of their use in sunscreens and other skin products.
  • Anatase is an aggressive free radical producer compared to rutile, another less reactive form of titanium dioxide used in sunscreens, cosmetics and other products.
  • W02017/210406 claimed a sunscreen composition having synergistic UV protection which comprises the non-nano ZnO and bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT).
  • ZnO used herein is either un-coated or coated with oxide compound e.g. silica or the organic material like silanes, silicones, organic titanates, fatty acids, metal soaps, polyols, dimethicones, and combinations thereof. It has SPF value of at least 15 or a PFA value of at least 8, or both.
  • An object of the invention is to provide a SPF agent which is non-coated and non-nano, particularly titanium dioxide and aluminium oxide-hydroxide, which eliminates the problems associated with the prior art.
  • Yet another object of the invention is to provide a sunscreen composition comprising SPF agent of the invention, which is safe, non-toxic and has an effective SPF value.
  • Yet another object of the invention is to provide a cosmetic or personal care formulation comprising SPF agent or sunscreen composition of the invention, which is safe, non-toxic and has an effective SPF value.
  • Yet another object of the invention is to provide an article comprising SPF agent, which is safe, non-toxic and has an effective SPF value.
  • the aluminium oxide-hydroxide in combination with titanium dioxide particularly in the ratio of 95 to 99 : 1 to 5 has a synergistic SPF value of at least 50.
  • it is non-nano and not coated with additional uv filters. It is manufactured by following simple procedures. Since, the mean particle size of SPF is above 200 nm it is safe and non-toxic. It is used in a sunscreen composition or cosmetic and personal care formulation or article which are safe and non-toxic to the human as well as aquatic eco- system.
  • the presently claimed invention is directed to a non-nano and non-coated sunscreen protection factor (SPF) agent comprising non-nano titanium dioxide and aluminium oxide -hydroxide in a ratio of 95 to 99 : 1 to 5; the agent has a synergistic SPF value of at least 50.
  • SPPF sunscreen protection factor
  • the non-nano titanium dioxide and aluminium oxide-hydroxide is in a ratio of 95 to 97: 5 to 3.
  • a particle size of titanium dioxide is at least above 100 nm, preferably in the range of 101 to 500 nm, more preferably in the range of 200 to 500 nm, most preferably 300 nm. Accordingly, in another embodiment, the presently claimed invention is directed to a manufacturing process for non-nano and non-coated sunscreen protection factor (SPF) agent according to the invention;
  • SPPF sunscreen protection factor
  • the non-nano titanium dioxide and aluminium oxide- hydroxide is in a ratio of 95 to 97 : 5 to 3.
  • the presently claimed invention is directed to a sunscreen composition for skin, hair and nail care, said composition comprising SPF agent according to invention.
  • the composition is pigmented or unpigmented lotion, cream, foundation, lip-stick, nail polish and pressed powder.
  • the presently claimed invention is directed to the sunscreen composition which further comprises UV filter agent or a topically active agent selected from anti-tanning agent, an antimicrobial agent, a depigmentation agent, an anti-aging agent, anti-fungal agent, an insect repellent, photochromic additive and a combination thereof.
  • the presently claimed invention is directed to cosmetic or personal care formulation comprising SPF agent or sun screen composition of the invention.
  • the presently claimed invention is directed to an article comprising SPF agent or sun screen composition of the invention.
  • non-nano refers to a median primary particle size is bigger than 100 nm.
  • Particle size is calculated by measuring the particles in photographs obtained using transmission electron microscopy or scanning electron microscopy. Number weighted distribution of the shortest dimension, when applicable, is used for size analysis and for discussion in this application.
  • weight percent when used without qualification, typically refers to the weight percent of a particular solid component as compared with all solid components present, excluding medium or vehicle.
  • cream is typically defined as the composition that does not flow out from a container at 25°C when it is turned upside down.
  • the term “lotion” is typically defined as the composition that flow out from the container at 25°C when turned upside down.
  • composition refers to a list of ingredients, and/or components, and can also include list of instructions for preparing and mixing together the ingredients, and/or components to make the composition.
  • a non-nano and non-coated sunscreen protection factor (SPF) agent typically comprises titanium dioxide and aluminium oxide-hydroxide in a ratio of 99 to 95 :l to 5.
  • it comprises titanium dioxide and aluminium oxide -hydroxide in a ratio of 95 to 97 : 5 to 3.
  • the titanium dioxide used herein has a mean particle size of at least above 100 nm.
  • the mean particle size of the titanium dioxide is in the range of 101 to 500 nm; more particularly 200 to 500 nm; more preferaby around 300 nm.
  • Titanium dioxide used herein is either of rutile grade or of anatase grade; preferably anatase.
  • the aluminium oxide-hydroxide (CAS No: 1333-84-2) used has pore volume of 0.8 to 1.0 g/ml and surface area of 250 m /g (minimum).
  • the titanium dioxide used herein is not coated with any additional UV filters or any other additive.
  • the non-nano and non-nano coated SPF has a synergistic SPF value of at least 50.
  • the SPF value of the SPF agent of the presently claimed invention is at least 50. Typically, it is in the range of 50 to 76.
  • the titanium dioxide was admixed with aluminium oxide -hydroxide in a ratio of 95 to 99 : 1 to 5 and it was milled further by jet milling to obtain uniform mixture having a mean particle size of 101 to 500 nm;
  • the mixture was calcinated in a muffle furnace at a temperature in the range of 800 to 1000° C for at least 4 hours;
  • the calcined product was ground by jet milling to get SPF agent having a mean particle size of at least above 100 nm and a synergistic SPF value of at least 50.
  • the titanium dioxide was admixed with aluminium oxide -hydroxide in a ratio of 95 to 97 : 5 to 3.
  • the mixture of step (b) was calcinated in a muffle furnace at a temperature in the range of 800 to 900° C.
  • the mixture of step (b) was calcinated in a muffle furnace at a temperature 840° C.
  • step (a) is carried out at a pressure of 1 to 8 bar and a temperature 5 to l5°C.
  • the jet milling of step (a) is carried out at the pressure of 8 bar and the temperature 8°C.
  • the mean particle size of the SPF agent so obtained in the step (c) is in the range of 101 to 500 nm; preferably 200 to 500 nm; more preferably around 300 nm.
  • a sunscreem composition comprising the SPF agent of the presently claimed invention and specifically used for skin, hair and nail care.
  • the sunscreen composition is either pigmented or unpigmented. It is in the form of a lotion, cream, gel, emulsion, powder depending upon the bases used therein. Preferably, it is in the form of cream, lotion or powder. It is used in the sun-scream, sun-lotion, foundation, lip-stick, nail polish and pressed powder.
  • the sunscreen composition of the presently claimed invention further comprising UV filter agent or a topically active agent selected from anti-tanning agent, an antimicrobial agent, a depigmnetation agent, an anti-aging agent, anti-fungal agent, an insect repellent, a photochromic additive and a combination thereof.
  • a topically active agent selected from anti-tanning agent, an antimicrobial agent, a depigmnetation agent, an anti-aging agent, anti-fungal agent, an insect repellent, a photochromic additive and a combination thereof.
  • the sunscreen compositions of the present invention may further comprise additional additives like antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, conditioners, exfoliating agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, skin healing agents, or the like.
  • additional additives like antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, conditioners, exfoliating agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, skin healing agents, or the like.
  • a cosmetic or personal care formulation comprising SPF agent or sun screen composition of the presently claimed invention.
  • Titanium dioxide (Anatasc) (Ti0 2 : 97-98%; Tinting Strength:l220 min; Specific Gravity 3.8 - 3.9; Refractive Index 2.5; pH: 6.5 - 8; Bulk Density (tamped) : 0.7 ⁇ 0.2 gm/cm , Mositure: 0.4% max.; Oil Absorption: 20 - 25 gm / 100 gm; and Average Particle Size: 300 to 700 m)
  • Titanium dioxide (Rutile) Ti0 2 : 93-94%; Tinting Strength: 1750 ⁇ 20; Specific Gravity: 4 - 4.2; Refractive Index 2.7; Rutile Content 99% min.; pH: 7-8.2; Bulk Density (tamped) : 1 ⁇ 0.2 gm/cm 3 ’ Mositure: ⁇ 0.3%; Oil Absorption: 18 - 20 gm / 100 gm; and Average Particle Size: 300 to 700 m)
  • Aluminium oxide -hydroxide (CAS No: 1333-84-2: pore volume of 0.8 to 1.0 g/ml and minimum surface area of 250 m /g, particle size of 300 to 400 nm]
  • the components A, B and C were mixed by jet milling at 8 bar and maintaining temperature at 8° C;
  • the calcined product i.e. SPF agent was cooled and further jet milled at 8 bar and maintaining temperature at 8° C to obtain SPF agents 1 to 6.
  • SPF agents (1) to (6) were tested for SPF value by COLIPA 2011 and mean particle size by ASTM E2651-13 (Particle size analysis). The results of SPF and particle size are illustrated in Table 2.
  • SPF value of Titanium dioxide (Rutile), Titanium dioxide (Anatase) and Aluminium oxide -hydroxide with median primary particle size of 300 nm is in the range of 2, 3 and 0 respectivley.
  • Aluminium oxide-hydroxide doesnt have SPF and Titanium dioxide (either Rutile or Anatase form) has SPF of 2 to 3 when tested individually but when SPF agents (1) to (6) comprises both Titanium dioxide (either Rutile or Anatase form) and Aluminium oxide -hydroxide in a particular proportion (99 to 95 : 1 to 5) and prepared according to the process of the invention demonstrate unexpected synergistic SPF value in the range of 50 to 76 at median primary particle size of 300 nm.
  • the SPF agent having a high SPF 30+ which is a broad spectrum UV protection according to both FDA and Cosmetic Europe regulations, and a ++++ UVA protection rating according to Japanese regulation.
  • the SPF agent may be further added in the formulation of the sunscreen composition or the cosmetic or personal care formulation or the articles like glass, paint formulation, automobile paint formulation.
  • the quantity of the SPF agent need to be added in the formulation as per the SPF requirement of the formulation.
  • the presently claimed invention facilitates SPF agents which comprises titanium dioxide and aluminium oxide -hydroxide where the median primary particle size of the titanium dioxide is 300 nm and having synergistic SPF value of at least 50, particularly 50 to 76.
  • the SPF agent of the presently claimed invention is safe and non toxic to human as well as aquatic eco system as well as having effective SPF value. It is converted into the sun screen composition as well as the cosmetic or personal care formulation. It can also be used in the article that require specific and effective SPF value. It is useful in the end applications including lotion, cream, foundation, lip-stick, nail polish and pressed powder.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un agent de facteur de protection solaire (FPS) non nanométrique et non revêtu comprenant du dioxyde de titane et de l'oxyde-hydroxyde d'aluminium non nanométriques dans un rapport de 99-95:1-5 ; l'agent présentant une valeur de FPS synergique d'au moins 50. L'agent est utilisé dans une formulation cosmétique ou de soin personnel ainsi que dans l'article qui nécessitent une valeur de FPS spécifique et efficace, en particulier dans les applications finales comprenant, mais sans y être limitées, une lotion, une crème, un fond de teint, un rouge à lèvres, un vernis à ongles et une poudre compacte.
PCT/IN2019/050553 2018-09-07 2019-07-27 Fps efficace et sûr, non nanométrique et non revêtu Ceased WO2020049585A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201821033750 2018-09-07
IN201821033750 2018-09-07

Publications (1)

Publication Number Publication Date
WO2020049585A1 true WO2020049585A1 (fr) 2020-03-12

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433086A1 (fr) * 1989-12-15 1991-06-19 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Composition anti-solaire
CA2296625A1 (fr) * 2000-01-18 2001-07-18 Fallien Cosmeceuticals, Ltd. Composition d'antioxydants et d'ecran solaire, resistante a la sueur
EP1977729A1 (fr) * 2007-04-05 2008-10-08 Eckart GmbH Compositions cosmétiques contenant des pigments nacrés
WO2013068970A2 (fr) * 2011-11-10 2013-05-16 University Of Kwazulu-Natal Compositions d'écran solaire
US20160058681A1 (en) * 2014-09-02 2016-03-03 Edgewell Personal Care Brands, Llc Mineral Sunscreen Compositions
WO2017210406A1 (fr) 2016-06-02 2017-12-07 Kobo Products, Inc. Compositions d'écran solaire
EP3315116A1 (fr) * 2016-10-28 2018-05-02 Cyberderm Laboratories Inc. Composition d'écran solaire topique, procédé de préparation et son utilisation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433086A1 (fr) * 1989-12-15 1991-06-19 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Composition anti-solaire
CA2296625A1 (fr) * 2000-01-18 2001-07-18 Fallien Cosmeceuticals, Ltd. Composition d'antioxydants et d'ecran solaire, resistante a la sueur
EP1977729A1 (fr) * 2007-04-05 2008-10-08 Eckart GmbH Compositions cosmétiques contenant des pigments nacrés
WO2013068970A2 (fr) * 2011-11-10 2013-05-16 University Of Kwazulu-Natal Compositions d'écran solaire
US20160058681A1 (en) * 2014-09-02 2016-03-03 Edgewell Personal Care Brands, Llc Mineral Sunscreen Compositions
WO2017210406A1 (fr) 2016-06-02 2017-12-07 Kobo Products, Inc. Compositions d'écran solaire
EP3315116A1 (fr) * 2016-10-28 2018-05-02 Cyberderm Laboratories Inc. Composition d'écran solaire topique, procédé de préparation et son utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARK BERNEBURG: "Induction of the Photoaging-associated Mitochondrial Common Deletion In Vivo in Normal Human Skin", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 122, no. 5, May 2004 (2004-05-01), pages 1277 - 1283
SERPONE N ET AL.: "Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight", J PHOTOCHEM PHOTOBIOL A CHEM, vol. 179, 2006, pages 200 - 212, XP028008532, doi:10.1016/j.jphotochem.2005.08.017
SIDDIQUEY IA ET AL.: "The effects of organic surface treatment by methacryloxypropyltrimethoxysilane on the photostability of Ti02", MATER CHEM PHYS, vol. 105, 2007, pages 162 - 168, XP022234140, doi:10.1016/j.matchemphys.2007.04.017

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