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WO2020049438A3 - Système de détection de composés organiques volatils (voc) dans l'haleine exhalée pour la surveillance de la santé - Google Patents

Système de détection de composés organiques volatils (voc) dans l'haleine exhalée pour la surveillance de la santé Download PDF

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Publication number
WO2020049438A3
WO2020049438A3 PCT/IB2019/057383 IB2019057383W WO2020049438A3 WO 2020049438 A3 WO2020049438 A3 WO 2020049438A3 IB 2019057383 W IB2019057383 W IB 2019057383W WO 2020049438 A3 WO2020049438 A3 WO 2020049438A3
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WO
WIPO (PCT)
Prior art keywords
exhaled breath
voc
detection
organic compounds
volatile organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2019/057383
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English (en)
Other versions
WO2020049438A2 (fr
WO2020049438A4 (fr
Inventor
Jilma PERUVANGAT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kozhnosys Private Ltd
Original Assignee
Kozhnosys Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kozhnosys Private Ltd filed Critical Kozhnosys Private Ltd
Priority to US17/272,966 priority Critical patent/US20210186367A1/en
Priority to EP19857652.2A priority patent/EP3846691A4/fr
Publication of WO2020049438A2 publication Critical patent/WO2020049438A2/fr
Publication of WO2020049438A3 publication Critical patent/WO2020049438A3/fr
Publication of WO2020049438A4 publication Critical patent/WO2020049438A4/fr
Anticipated expiration legal-status Critical
Priority to US18/404,292 priority patent/US20240206762A1/en
Priority to US18/404,192 priority patent/US20240225477A9/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2437—Piezoelectric probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/021—Gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G01N2291/0257—Adsorption, desorption, surface mass change, e.g. on biosensors with a layer containing at least one organic compound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/64—Electrical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10N30/00—Piezoelectric or electrostrictive devices
    • H10N30/30—Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
    • H10N30/302—Sensors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Nanotechnology (AREA)
  • Acoustics & Sound (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un système de détection de composés organiques volatils (COV) dans l'haleine exhalée pour la surveillance de la santé. Elle peut être utilisée pour le dépistage, le diagnostic, le suivi de l'apparition de maladies et la rechute liée à celles-ci. Certains composés volatils présents dans l'haleine exhalée d'une personne, qui sont les marqueurs de la maladie considérée, vont être analysés par le réseau de capteurs. La présence et la concentration de ces marqueurs seront déterminées par un réseau de capteurs spécifique pour l'ensemble de marqueurs de la maladie. En fonction de la présence ou non et des niveaux de concentration de ces COV, l'état de santé d'une personne peut être analysé. La présente invention concerne également un dispositif permettant de surveiller des états de santé d'un individu et de dépister la présence de maladies ou la rechute liée à celles-ci.
PCT/IB2019/057383 2018-09-03 2019-09-02 Système de détection de composés organiques volatils (voc) dans l'haleine exhalée pour la surveillance de la santé Ceased WO2020049438A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US17/272,966 US20210186367A1 (en) 2018-09-03 2019-09-02 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring
EP19857652.2A EP3846691A4 (fr) 2018-09-03 2019-09-02 Système de détection de composés organiques volatils (voc) dans l'haleine exhalée pour la surveillance de la santé
US18/404,292 US20240206762A1 (en) 2018-09-03 2024-01-04 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring
US18/404,192 US20240225477A9 (en) 2018-09-03 2024-01-04 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201821016758 2018-09-03
IN201821016758 2018-09-03

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US17/272,966 A-371-Of-International US20210186367A1 (en) 2018-09-03 2019-09-02 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring
US18/404,192 Division US20240225477A9 (en) 2018-09-03 2024-01-04 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring
US18/404,292 Division US20240206762A1 (en) 2018-09-03 2024-01-04 System for detection of volatile organic compounds (voc) in exhaled breath for health monitoring

Publications (3)

Publication Number Publication Date
WO2020049438A2 WO2020049438A2 (fr) 2020-03-12
WO2020049438A3 true WO2020049438A3 (fr) 2020-06-18
WO2020049438A4 WO2020049438A4 (fr) 2020-09-03

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PCT/IB2019/057383 Ceased WO2020049438A2 (fr) 2018-09-03 2019-09-02 Système de détection de composés organiques volatils (voc) dans l'haleine exhalée pour la surveillance de la santé

Country Status (3)

Country Link
US (3) US20210186367A1 (fr)
EP (1) EP3846691A4 (fr)
WO (1) WO2020049438A2 (fr)

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US20230263427A1 (en) * 2020-09-08 2023-08-24 National University Of Singapore An apparatus for collecting breath
CN112255354B (zh) * 2020-09-11 2021-09-10 广州医科大学附属第一医院 马尔尼菲篮状菌病诊断的特征物及其筛选方法和应用
CN112694564A (zh) * 2020-12-23 2021-04-23 北京工业大学 一种糠醛类分子印迹聚合物的制备方法与应用
ES2906212B2 (es) * 2021-04-22 2023-06-22 Univ Valencia Politecnica Biosensor y virusometro de deteccion de patogenos en aire y en muestras liquidas
JP7718650B2 (ja) * 2021-05-19 2025-08-05 国立大学法人東北大学 感染症のバイオマーカ
US20220378342A1 (en) * 2021-05-25 2022-12-01 California Institute Of Technology Wearable autonomous biomimetic sweat sensor for precision nutrition
CN115236220B (zh) * 2022-06-23 2023-12-19 上海交通大学 一种诊断新型冠状病毒的挥发性标志物及其应用
CN118883921B (zh) * 2024-08-05 2025-09-05 中南大学湘雅医院 一种基于呼出气中挥发性有机化合物的阿尔茨海默病诊断标志物及其应用

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Also Published As

Publication number Publication date
WO2020049438A2 (fr) 2020-03-12
EP3846691A4 (fr) 2022-06-15
EP3846691A2 (fr) 2021-07-14
US20240130632A1 (en) 2024-04-25
WO2020049438A4 (fr) 2020-09-03
US20240225477A9 (en) 2024-07-11
US20210186367A1 (en) 2021-06-24
US20240206762A1 (en) 2024-06-27

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