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WO2019235340A1 - Dispositif de biopsie, appareil d'injection permettant d'injecter ledit dispositif de biopsie et appareil de biopsie équipé de ce dernier - Google Patents

Dispositif de biopsie, appareil d'injection permettant d'injecter ledit dispositif de biopsie et appareil de biopsie équipé de ce dernier Download PDF

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Publication number
WO2019235340A1
WO2019235340A1 PCT/JP2019/021443 JP2019021443W WO2019235340A1 WO 2019235340 A1 WO2019235340 A1 WO 2019235340A1 JP 2019021443 W JP2019021443 W JP 2019021443W WO 2019235340 A1 WO2019235340 A1 WO 2019235340A1
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WO
WIPO (PCT)
Prior art keywords
biopsy device
needle
needle member
sample collection
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2019/021443
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English (en)
Japanese (ja)
Inventor
義弘 藤原
真二 土田
勝 河戸
殊大 増田
俊宏 巻
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Agency for Marine Earth Science and Technology
Original Assignee
Japan Agency for Marine Earth Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Agency for Marine Earth Science and Technology filed Critical Japan Agency for Marine Earth Science and Technology
Priority to JP2020523663A priority Critical patent/JP6984922B2/ja
Publication of WO2019235340A1 publication Critical patent/WO2019235340A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
    • F41B7/00—Spring guns
    • F41B7/04—Spring guns adapted to discharge harpoons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit

Definitions

  • the present invention relates to a biopsy device for collecting a biological sample from a sample collection object such as an animal or fish, an injection apparatus for injecting the biopsy device, and a biopsy apparatus including these.
  • biopsy gun a biological sample is also collected from a sample collection object non-lethally.
  • Non-patent Document 2 As an example of the collection of biological samples using biopsy guns, etc., the Japanese Whale Research Institute “2014/15 Porting of the Antarctic Sea Whale Visual Survey” published on January 6, 2015 (non-patent literature) 1), “The results of the 2015/2017 New Antarctic Whale Science Survey (NEWREP-A)” published on March 24, 2016 (Non-patent Document 2).
  • Non-Patent Documents 1 and 2 release a biopsy device having a needle portion toward a biological sample collection target.
  • the needle part has a cylindrical shape whose tip is open toward the biological sample collection object.
  • the tip cuts through the skin and a part of the meat, and the biological sample is stored in the needle part. Thereafter, the biological sample is collected by collecting the biopsy device.
  • Japan Whale Research Institute “2014/15 Port of Antarctic Sea Whale Visual Survey” published on January 6, 2015 (Search on March 22, 2018, URL: http: //www.icrwhale .org / pdf / 150106ReleaseJp.pdf)
  • the Japan Whale Research Institute “2015/2017 New Antarctic Ocean Whale Science Survey (NEWREP-A)" published on March 24, 2016 (March 22, 2018 search URL: http : //www.icrwhale.org/pdf/160324ReleaseJp.pdf)
  • Patent Documents 1 and 2 are operated by an operator to store the needle portion in the needle storage body. For this reason, there is a problem that it cannot be used for sample collection objects such as wildlife and deep sea fish that are difficult for humans to approach.
  • An object of the present invention is to provide a biopsy device capable of collecting a biological sample in a non-lethal and well-preserved state without human operation.
  • Another object of the present invention is to provide a biopsy device capable of reducing damage to a sample collection object and collecting a biological sample.
  • Still another object of the present invention is to provide an injection apparatus and a biopsy apparatus for injecting a biopsy device capable of collecting a biological sample from a sample collection object that is difficult for humans to approach.
  • the biopsy device of the present invention includes a needle member, a needle member storage body, a housing including one or more stopper portions, and a drive mechanism that pulls the needle member into the needle member storage path.
  • the needle member has a pointed portion at the tip, a sample intake opening that opens outwardly behind the pointed portion, and a needle portion in which a sample intake recess for taking in a sample is formed, and the needle portion It has a rod part in the rear.
  • the needle member storage body is a cylindrical member that has an opening at the tip and includes a needle member storage path that stores the needle member slidably in the longitudinal direction of the needle member.
  • the one or more stoppers provided in the housing have a contact surface, and the contact surface is in contact with the sample collection object, thereby limiting the depth at which the sharp part of the needle part enters the sample collection object. It is.
  • the drive mechanism is configured such that the sample intake port is positioned on the outer side in the longitudinal direction of the contact surface of the one or more stopper portions before sampling, and the sample contact surface of the one or more stopper portions contacts the sample collection object.
  • the needle member is drawn into the needle member storage path so that the intake port is positioned in the needle member storage path.
  • the biopsy device of the present invention is configured as described above, the biological sample can be collected without the needle portion entering the sample collection object more than necessary, and the biological sample is exposed to the outside. Therefore, if the biopsy device is collected, it is possible to collect a biological sample with a good preservation state.
  • the shape and angle of the sharp part of the needle part are arbitrary.
  • it may be a triangular pyramid or conical shape whose top is directed to the object to be sampled, or it may have a shape like an injection needle in which a cylinder is cut obliquely.
  • it may be changed depending on the type of the object to be sampled.
  • the inventors assumed a deep-sea shark inhabiting the deep sea (several hundreds of meters to 2,000 meters of water) as an object to be sampled, and examined the shape and angle of the sharp part. Since deep-sea sharks are often hard and thick, a sharp type of sharp point that can penetrate the skin is required. However, if the deep-sea shark is damaged too much, the objective of collecting a biological sample non-lethally cannot be achieved. Therefore, it is necessary to examine the shape and angle considered to be optimal. As a result, in the case of deep-sea sharks, it was found that a triangular pyramid shape is suitable for the shape of the sharp point.
  • the angle of the sharp portion is formed between a virtual surface including one of the three surfaces constituting the triangular pyramid sharp portion and a virtual line extending along the ridgeline formed by the other two surfaces. It has been found that an angle between 20 ° and 40 °, in particular an angle of 30 °, is suitable.
  • the depth at which the sharp part of the needle part enters the sample collection object is determined by the sharp part of the needle part being the sample collection object It is preferable that the depth does not reach the internal organs.
  • the sample intake port is preferably formed at a position where the muscle tissue of the sample collection target can be collected. Specifically, this position is a position between 20 mm and 50 mm behind the sharp part of the needle part.
  • the drive mechanism may include a retracting energy storage member and an engagement mechanism.
  • the pulling-in energy storage member is stored when the needle member is moved to a first position where the sample intake port is located on the outer side in the longitudinal direction of the contact surface of the one or more stopper portions. It is released when it is drawn into the member storage path and moved to the second position.
  • the engagement mechanism is engaged with the needle member when the needle member is in the first position, and the contact surface of the one or more stopper portions contacts the sample collection object, and an external force directed backward is applied to the stopper portion. Sometimes the engagement with the needle member is released.
  • the engagement mechanism may include a housing slide mechanism, a plurality of through holes formed in the needle member housing, and an engagement member.
  • the housing slide mechanism holds the housing in a steady position when no external force is applied to the contact surface of the one or more stopper portions, and the housing is located behind the steady position when an external force is applied to the one or more stopper portions.
  • the housing is allowed to move, and when the external force disappears, the housing is returned to the steady position.
  • the plurality of through holes are formed at intervals in the circumferential direction of the needle member storage body, and penetrate the peripheral wall of the needle member storage body in the radial direction.
  • the engaging members are respectively held in the plurality of through holes so as to be movable in the radial direction.
  • a flange portion is provided at the rear end portion of the rod portion of the needle member, and the inner peripheral portion of the peripheral wall of the needle member storage body is one or more protrusions protruding radially inward at positions on the rear side of the plurality of through holes.
  • a coil-like spring member which is a retraction accumulating member, is arranged between the flange portion of the needle member and one or more protrusions, and the housing moves rearward by the housing slide mechanism, the spring member is released You may be made to do.
  • the housing slide mechanism is disposed between an end cap fixed to the rear end portion of the needle member housing, and between the end cap and the rear end portion of the housing, and accumulates energy when an external force is applied to the housing. Further, it may be composed of a return accumulating member which is released when the external force is lost and returns the housing to the steady position.
  • the return accumulating member may be a coiled spring member, and the spring member may be fitted into the needle member housing.
  • An annular recess that allows the engaging member to be displaced radially outward when the housing is lowered rearward from the steady position may be provided in the inner peripheral portion of the housing.
  • a cylindrical posture stabilizing spoiler may be attached to the outside of the end cap via a plurality of pins. In this way, when the biopsy device is skipped, the posture of the biopsy device can be stabilized in the air or in water, and the accuracy of the sample collection object is improved.
  • the biopsy device may of course be thrown and used by humans, but may also be used with an injection device that injects the needle portion in a posture toward the sample collection object.
  • the injection apparatus has a rod-shaped member whose tip is connected to the rear end of the biopsy device, a coupler provided at the rear end of the rod-shaped member, an opening at the front end, and the biopsy device and the biopsy device in a standby state
  • a cylinder that houses the rod-like member connected to the cylinder, and a locking state that is provided at the rear end of the cylinder and that is engaged with the coupler provided at the rear end of the rod-like member in the standby state.
  • the coupler locking mechanism that is in a released state that releases the locking state based on the position of the coupler and the coupler locking mechanism is disposed between the rear end of the biopsy device disposed inside the cylinder and the coupler locking mechanism. It can be stored in the process of being locked by the mechanism, and can be released when the coupler locking mechanism is released, and can be provided with an injection energy storage member for injecting the biopsy device.
  • the injection apparatus has a misfire prevention mechanism.
  • the misfire prevention mechanism prevents the biopsy device from being ejected from the opening of the cylinder when the coupler locking mechanism is accidentally released while the biopsy device is stored in the cylinder. is there.
  • it may be a pullable safety pin arranged on the ray of the biopsy device in a state where the biopsy device is housed in the cylinder.
  • the safety pin may be pulled out.
  • the misfire prevention mechanism is positioned on the ray of the biopsy device in a state where the biopsy device is housed in the cylinder, and passes through the biopsy device. It may be an elastic sphere member that is blocked and crushed by water pressure to allow passage of the biopsy device when the injection device is submerged.
  • only one of these misfire prevention mechanisms may be provided, or both may be provided.
  • the injection device may be a device that injects by remote operation, or may be a type that outputs an injection command to the injection device when a sample collection object is detected.
  • it is only necessary to further include an organism command detection unit that detects an organism that has entered the range, and an injection command output unit that outputs an injection command to the injection device when the organism detection unit detects the sample collection target.
  • an organism command detection unit that detects an organism that has entered the range
  • an injection command output unit that outputs an injection command to the injection device when the organism detection unit detects the sample collection target.
  • the size or shape of the sample collection object can be used as a reference for determining whether or not the object is a sample collection object. It can be said that a sample collection object is detected when a living thing having a size larger than a predetermined size and / or shape is detected.
  • the method for detecting the sample collection object using the biological detection unit is arbitrary.
  • the sample collection object may be detected based on an image obtained by using a light cutting method using laser light.
  • the present invention can also be understood as a biopsy device including the biopsy device described above and an injection device that injects the biopsy device in a posture in which the needle portion is directed to the sample collection target.
  • FIG. 1 is a perspective view of the biopsy apparatus 1
  • FIG. 2 is an exploded perspective view of a launcher 21 that constitutes a part of an injection device 5 that injects a biopsy device 19.
  • FIG. 3 is a partial cross-sectional view of a launcher 21 in a state before injection containing a biopsy device 19.
  • (A) to (C) are schematic views showing the state of prevention of misfiring by the elastic sphere members 47 and 49.
  • FIG. 4 is a flowchart until the biopsy device 19 is ejected.
  • 2 is an exploded perspective view of a biopsy device 19.
  • FIG. It is sectional drawing of the biopsy device 19 of the state which accommodated the sample intake. It is sectional drawing of the biopsy device 19 of the state which exposed the sample intake. It is an enlarged view of the needle part 67.
  • FIG. It is a figure which shows the experimental result of Experiment 1.
  • FIG. It is a figure which shows the experimental result of Experiment 2.
  • FIG. 1A and 1B show an example of a biopsy device 1 according to the present embodiment.
  • FIG. 1A is a perspective view of the biopsy device 1
  • FIG. 1B is a front view of the biopsy device 1.
  • the biopsy device 1 uses large fish such as deep-sea sharks living in the deep sea at a depth of several hundred to 2,000 meters as samples, and transports them to the sea at the installation site by ship and inputs them from the sea. Then, it is used by setting it to the sea floor.
  • the biopsy device is not housed in the launcher.
  • FIG. 2 is a block diagram of the injection apparatus.
  • a plurality of directions are defined with respect to the biopsy device 1. That is, the left-right direction (first direction D1) composed of the right direction Ri and the left direction Le, the up-down direction (second direction D2) composed of the upward direction Up and the downward direction Lo, the front-rear direction composed of the forward direction Fo and the backward direction Re.
  • the direction (third direction D3) is defined as shown in FIG.
  • the direction used in the description of each constituent member is a direction in a state where each constituent member is attached to the frame body 3. In the description of the structure shown in FIGS. 3, 4, and 7 to 10, the same direction as that used in the description of FIG. 1 is used.
  • the biopsy device 1 includes a frame body 3, an injection device 5, a main pressure resistant container 7, an LED light 9, a buoyancy material 11, an acoustic transponder 13, a flasher 15, a radio beacon 17, and an ultrasonic Doppler flow direction.
  • An anemometer 18 is provided.
  • the frame body 3 is composed of a metal frame and is provided with various members.
  • a suspension point 4 for lifting with a crane is provided in the upper central portion.
  • the injection device 5 is controlled by the four biopsy devices 19, four launchers 21 for injecting the biopsy devices 19, a control unit 23 installed in the main pressure-resistant container 7 and a processor, and the control unit 23. It comprises a launcher control unit 25 for controlling the emission of the light, a sheet laser irradiation unit 27, and a laser monitoring camera 29.
  • the object to be sampled is monitored by a light cutting method using the sheet laser irradiation unit 27 and the laser monitoring camera 29.
  • the control unit 23 includes a sheet laser irradiation control unit 23 ⁇ / b> A that controls the sheet laser irradiation unit 27, a biological detection unit 23 ⁇ / b> B that detects a sample collection object based on an image acquired by the laser monitoring camera 29, and the launcher control unit 2. Is provided with an injection command output unit 23C for outputting an injection command.
  • the main pressure-resistant container 7 is a cylindrical container that stores the main camera 31 for external photographing in addition to the control unit 23 and the launcher control unit 25 in a watertight manner.
  • the LED light 9 is for irradiating the outside in the deep sea where light does not reach, and is mainly for assisting the photographing of the main camera 31.
  • the buoyancy material 11 is installed while the biopsy device 1 is being transported, and is removed before being submerged in the sea.
  • the acoustic transponder 13 is for receiving a levitation command from a marine vessel, and is combined with a separation device for separating a ballast (not shown) provided in the biopsy device 1. When the ascent command is received, the ballast is cut off and the biopsy device 1 rises.
  • the flasher 15 is an illuminating tool for making it easier for a recoverer to visually recognize the surface of the sea after the biopsy device 1 floats on the sea.
  • the radio beacon 17 transmits a radio wave after the biopsy device 1 has surfaced on the sea to inform the position of the biopsy device 1.
  • the ultrasonic Doppler flow direction anemometer 18 measures the flow direction and the flow speed of the seawater around the biopsy device 1.
  • FIG. 3 is an exploded perspective view of the launcher 21 that constitutes a part of the injection device 5 that injects the biopsy device 19.
  • FIG. 4 shows the cylinder 37 of the launcher 21 in the state before the injection containing the biopsy device 19 and
  • FIG. 5 is a partial cross-sectional view showing an injection energy storage member 41 in cross section.
  • the launcher 21 has a rod-shaped member 33 whose tip is connected to the rear end of the biopsy device 19, a coupler 35 provided at the rear end of the rod-shaped member 33, and an opening 37A at the front end.
  • a cylindrical body 37 that houses the biopsy device 19 and the rod-shaped member 33 connected to the biopsy device 19, a coupler locking mechanism 39 provided at the rear end of the cylindrical body 37, and a storage for injection that injects the biopsy device 19. And a force member 41.
  • the coupler locking mechanism 39 is electrically connected to the launcher control unit 25 and enters a locked state in which the coupler 35 provided at the rear end of the rod-shaped member 33 is locked in the standby state, and is based on an injection command. To release the locked state.
  • the injection accumulating member 41 is disposed between the rear end of the biopsy device 19 disposed inside the cylindrical body 37 and the coupler locking mechanism 39, and the coupler 35 is locked to the coupler locking mechanism 39. The energy is accumulated in the process, and is released when the coupler locking mechanism 39 is released.
  • the force for injecting the biopsy device 19 can be adjusted.
  • the biopsy device 19 is adjusted to be ejected with a force of about 500 N.
  • One end of the coupler 35 is fixed to the frame body 3, and the other end of the wire 36 passed through a through hole 39A formed in the coupler locking mechanism 39 is fastened (FIGS. 1A and 1B). reference). Thereby, even after the biopsy device 19 is injected from the launcher 21, the biopsy device 19 is connected to the biopsy device 1, and the biopsy device 19 can be recovered by recovering the biopsy device 1. Become.
  • the first misfire prevention mechanism is formed in the vicinity of the opening 37 ⁇ / b> A of the cylindrical body 37, two through holes 37 ⁇ / b> B and 37 ⁇ / b> C formed at positions aligned with the vertical direction D ⁇ b> 2, and the biopsy device 19 in the cylindrical body 37.
  • it is comprised on the ray of the biopsy device 19, and is comprised from the safety pin 43 which can be pulled out and fixed through the through-holes 37B and 37C.
  • the safety pin 43 is pulled out immediately before the biopsy device 1 is introduced from the sea.
  • the second misfire prevention mechanism includes a passage portion 45 provided in the vicinity of the opening portion 37A and extending in the vertical direction D2, and elastic spherical members 47 and 49 housed in the passage portion 45.
  • elastic sphere members 47 and 49 soft baseball balls or the like can be used.
  • FIGS. 5A to 5C are schematic views showing a state of prevention of misfiring by the elastic sphere members 47 and 49.
  • FIG. 5A is a diagram showing a state before the biopsy device 1 is thrown into the sea. In this state, due to gravity, the elastic sphere members 47 and 49 are located below the passage portion 45, and the elastic sphere member 47 prevents the biopsy device 19 from being misfired.
  • FIG. 5A is a diagram showing a state before the biopsy device 1 is thrown into the sea. In this state, due to gravity, the elastic sphere members 47 and 49 are located below the passage portion 45, and the elastic sphere member 47 prevents the biopsy device 19 from being misfired.
  • FIG. 5 (B) is a diagram showing a state up to about 30 m after the biopsy device 1 is introduced into the sea. In this state, buoyancy is generated by the seawater, and the elastic sphere members 47 and 49 are located above the passage portion 45, and the elastic sphere member 49 prevents the biopsy device 19 from being misfired.
  • FIG. 5C is a diagram illustrating a state in which the biopsy device 1 has arrived at the seabed at the installation point. In this state, the elastic sphere members 47 and 49 are crushed by the water pressure and are positioned above the passage portion 45. Accordingly, in this state, passage of the biopsy device 19 is allowed.
  • FIG. 6 is a flowchart until the injection device 5 of the biopsy device 1 installed on the seabed injects the biopsy device 19.
  • the sheet laser irradiation control unit 23A controls the sheet laser irradiation unit 27 to irradiate the sheet laser in front of the biopsy device 1 (step ST1).
  • the organism detection unit 23B generates three-dimensional image data based on the reflected light of the laser light acquired by the laser monitoring camera 29, and checks whether or not there is an organism such as a fish within the range of the injection device 5 (step) ST2).
  • a food basket containing a mackerel fillet (not shown) is prepared in front of the biopsy device 1, and the sample collection object is drawn in the range.
  • step ST3 When it is detected that the laser beam is disturbed, it is detected that a living organism has arrived, but this alone may be a small fish that is not a sample collection target, so in this embodiment, Further, based on the reflected light of the laser light, it is determined whether the detected organism has a certain size and shape, that is, a sample collection target (step ST3). For example, when the laser beam is finely disturbed, it is highly possible that the fish is a small fish, and when the laser beam is greatly curved, it can be determined that the fish is likely to be a large fish. If it is determined that the sample is an object to be sampled, the injection command output unit 23C outputs an injection command to the launcher control unit 25 and injects the biopsy device 19 (step ST4). In this embodiment, since four launchers 21 are provided, steps ST1 to ST4 are repeated until all four are launched (step ST5).
  • FIG. 8 is a cross-sectional view of the biopsy device 19 in a state in which the sample intake port is accommodated
  • FIG. 9 is a biopsy in a state in which the sample intake port is exposed.
  • FIG. 4 is a cross-sectional view of device 19.
  • the biopsy device 19 includes a needle member 51, a needle member housing 53, four stopper portions 55, a housing 57, a cylindrical cutter 59, an end cap 61, and a first accumulating member for retraction.
  • a spring member 63 and a second spring member 65 constituting a return accumulating member are provided.
  • the needle member 51 is made of metal and is a portion that pierces the biological sample collection object.
  • the needle member 51 has a needle portion 67 and a rod portion 69 at the rear thereof.
  • the needle portion 67 has a diameter of 6 mm, has a pointed portion 71 at the tip, and has a sample intake port 73 that opens toward the outside at the rear of the pointed portion 71 and takes in a sample taking-in recess 75. Is formed.
  • FIG. 10 is an enlarged view of the needle portion 67 of the present embodiment.
  • the shape of the sharpened portion 71 is a triangular pyramid whose top is directed to the object to be sampled, and a virtual surface IF including one of the three surfaces constituting the sharpened portion 71 and the other two surfaces are formed.
  • the angle ⁇ formed between the imaginary line IL extending along the ridge line is 30 °. This shape was determined through the experimental results shown in FIGS.
  • Experiment 1 Determination of Diameter and Shape
  • the diameter and shape of the needle part were compared and examined.
  • the diameter of the needle portion 63 is changed to 6 mm and 8 mm
  • a static penetration test test to pierce a stationary specimen with a needle portion
  • penetration resistance N
  • FIG. 11 penetration resistance
  • Experiment 2 Determination of the angle of the triangular pyramid sharp portion
  • the angle of the triangular pyramid sharp portion and the penetration resistance were compared. Angles formed between a virtual surface IF including one of the three surfaces constituting the sharp part and a virtual line IL extending along the ridgeline formed by the other two surfaces are 20 °, 30 °, and 40 Changed to ° C, a static penetration test was conducted on each of the three deep-sea sharks (Sagami Shark, Shark Shark, and Yellow Shark), the penetration resistance (N) was measured, and an average value (arithmetic mean) was calculated (FIG. 12). . When the angle is low, the skin could penetrate through the skin with a low load. However, when the angle is 20 ° and 30 °, there is no significant difference in the load required for penetration. The angle is 30 ° because the length of the sample reaches the internal organs of the object to be sampled and damage is likely to increase.
  • the sample inlet 73 is formed at a position where the muscle tissue can be collected in order to use the muscle tissue of the sample collection target as a biological sample.
  • the object to be sampled is a deep sea shark, and is formed at a position between 20 mm and 50 mm behind the sharp point 71.
  • the length L from the top of the sharp portion to the center of the sample intake port 73 is set to 30 mm.
  • An annular recess 69A is formed on the outer periphery of the rod portion 69 of the needle member 51, and a flange portion 69B is provided on the rear end.
  • the needle member storage body 53 is made of metal and has a cylindrical shape including a needle member storage path 53B that has an opening 53A at the tip and stores the needle member 51 so as to be slidable in the longitudinal direction thereof.
  • the peripheral wall is provided with three through holes 53C that penetrate in the radial direction, and protrusions 53D that project inward in the radial direction at positions on the rear side of the through holes 53C (see FIG. 8).
  • a ceramic ball-shaped member 77 that functions as an engaging member is held in the through hole 53C so as to be movable in the radial direction.
  • the stopper 55 includes a contact surface 55A.
  • the contact surface 55A comes into contact with the sample collection object, the depth at which the sharpened portion 71 of the needle portion 67 enters the sample collection object is limited. . In the present embodiment, four are provided, but the number is not limited to this, and other shapes such as a ring surrounding the needle portion 67 may be used.
  • the housing 57 is made of resin and stores the needle member storage body 53.
  • a stopper 55 is fixed to the tip, and an annular recess 57A is provided on the inner periphery.
  • the cylindrical cutter 59 is housed in the opening 53 ⁇ / b> A of the needle member housing 53 and is disposed around the needle portion 67 of the needle member 51.
  • the end cap 61 is fixed to the rear end portion of the needle member housing 53 by a screw-in type.
  • a cylindrical posture stabilizing spoiler 79 is attached to the outside of the end cap 61 via three pins. Thereby, the posture of the biopsy device 19 traveling in water is stabilized, and the accuracy of the sample collection target object is improved.
  • the first spring member 63 is an energizing member for retraction that draws the needle member 51 into the needle member storage path 53B.
  • the first spring member 63 is disposed between the flange portion 69 ⁇ / b> B of the needle member 51 and the protrusion 53 ⁇ / b> D provided inside the needle member storage body 53.
  • the second spring member 65 is fitted into the needle member housing 53 and is disposed between the end cap 61 and the rear end portion of the housing 57, and is stored when an external force is applied to the housing 57.
  • the return accumulating member is released when the external force disappears and returns the housing 57 to the steady position.
  • a housing slide mechanism is formed by the end cap 61 and the second spring member 65.
  • the biopsy device 19 is mounted with a drive mechanism realized by the cooperation of the above-described members.
  • the sample intake port 73 is stopped before the sample collection by a driving mechanism including the stopper portion 55, the housing 57, the first spring member 63, the second spring member 65, the ball-shaped member 77, the concave portion 57A and the like.
  • a driving mechanism including the stopper portion 55, the housing 57, the first spring member 63, the second spring member 65, the ball-shaped member 77, the concave portion 57A and the like.
  • the state shown in FIG. 8 is obtained.
  • the position of the needle member 51 in a state where the sample intake port 73 is located on the outer side in the longitudinal direction from the contact surface 55A of the stopper portion 55 is defined as the first position, and the needle member 51 is the needle member.
  • the position of the needle member 51 in a state of being drawn into the storage path 53B is defined as the second position.
  • the state shown in FIG. 8 is a state in which the needle member 51 is in the second position.
  • the sharp portion 71 of the needle member 51 first pierces the sample collection target, and then contacts the stopper portion 55.
  • the surface 55A collides with the object to be sampled.
  • an external force toward the rear is applied to the stopper portion 55, the housing 57 moves to the rear side from the steady position, and the annular recess 57A formed in the inner peripheral portion of the housing 57 moves to the position of the three through holes 53C.
  • the second spring member 65 is stored together.
  • the ball-shaped member 77 is allowed to displace radially outward, and a part of the ball-shaped member 77 escapes into the annular recess 57A, so that the needle member 51 and the ball-shaped member 77 are engaged. Canceled.
  • the first spring member 63 is released and the needle member 51 is drawn into the needle member storage path 53B so as to move to the second position.
  • the second spring member 65 is released and the housing 57 returns to the steady position.
  • the biopsy device 19 returns to the state shown in FIG. In this manner, a biological sample can be taken into the sample taking recess 75 and stored in the needle member storage path 53B without human operation.
  • the biopsy device may be used by being installed on the bottom of a lake in addition to the seabed, and of course, it can be used on the ground to collect a biological sample from a wild animal.
  • the shape of the sharp part of the needle part, the position of the sample inlet, the distance from the top part of the sharp part to the stopper part, the radiant output of the biopsy device Etc., and an appropriate misfire prevention mechanism is preferably employed.
  • a biopsy device that can collect a biological sample in a non-lethal and well-preserved state without human operation.
  • a biopsy device that can reduce the load on the sample collection object and collect a biological sample.
  • an injection apparatus and a biopsy apparatus for injecting a biopsy device that can collect a biological sample from a sample collection object that is difficult for humans to approach.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'objectif de la présente invention est de fournir un dispositif de biopsie, un appareil d'injection et un appareil de biopsie grâce auxquels il est possible de collecter un échantillon biologique de manière non létale et dans une bonne condition de confinement, sans intervention d'un être humain. Un appareil de biopsie (1) est pourvu : d'un élément d'aiguille (51); d'un corps de logement d'élément d'aiguille (53); d'un boîtier (57), pourvu d'une partie de butée (55); d'un dispositif de biopsie (19) pourvu d'un mécanisme d'entraînement permettant de conduire l'élément d'aiguille (51) dans un passage de réception d'élément d'aiguille (53B); et un appareil d'injection (5), permettant d'injecter le dispositif de biopsie (19), tandis qu'une partie d'aiguille (67) adopte une position orientée vers un objet cible de collecte d'échantillon. Le dispositif de biopsie (19) est injecté lors de la détection de l'objet cible de collecte d'échantillon. Une partie pointue (71) de l'élément d'aiguille (51) perce l'objet cible de collecte d'échantillon, après quoi, lorsqu'une surface de contact (55A) de la partie de butée (55) heurte l'objet cible de collecte d'échantillon, l'élément d'aiguille (51) est conduit dans le passage de logement d'élément d'aiguille (53B) au moyen du mécanisme d'entraînement.
PCT/JP2019/021443 2018-06-05 2019-05-30 Dispositif de biopsie, appareil d'injection permettant d'injecter ledit dispositif de biopsie et appareil de biopsie équipé de ce dernier Ceased WO2019235340A1 (fr)

Priority Applications (1)

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JP2020523663A JP6984922B2 (ja) 2018-06-05 2019-05-30 バイオプシーデバイス、該バイオプシーデバイスを射出するための射出装置、及び、これらを備えたバイオプシー装置

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JP2018-107507 2018-06-05

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005073554A (ja) * 2003-08-29 2005-03-24 Fujikin Inc チョウザメ検卵器具
WO2013040631A1 (fr) * 2011-09-20 2013-03-28 Commonwealth Scientific And Industrial Research Organisation Dispositif d'échantillonnage de tissu
JP2016148675A (ja) * 2012-01-10 2016-08-18 ユーシー—ケア リミテッド． 生物組織ハンドリング装置および方法
US20180014818A1 (en) * 2016-07-15 2018-01-18 Tissuegrab Biopsy Systems Llc Mammal and fish biopsy dart

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3924291C2 (de) * 1989-07-22 2000-07-13 Bip Acquisition Company Inc Biopsiekanäle zur Entnahme von Gewebeproben
WO2005037106A2 (fr) * 2003-10-14 2005-04-28 Suros Surgical Systems, Inc. Ensemble d'aiguilles de biopsie par aspiration
KR20190008953A (ko) * 2016-05-25 2019-01-25 쓰리디 바이옵시 인코포레이티드 생검 바늘 디자인

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005073554A (ja) * 2003-08-29 2005-03-24 Fujikin Inc チョウザメ検卵器具
WO2013040631A1 (fr) * 2011-09-20 2013-03-28 Commonwealth Scientific And Industrial Research Organisation Dispositif d'échantillonnage de tissu
JP2016148675A (ja) * 2012-01-10 2016-08-18 ユーシー—ケア リミテッド． 生物組織ハンドリング装置および方法
US20180014818A1 (en) * 2016-07-15 2018-01-18 Tissuegrab Biopsy Systems Llc Mammal and fish biopsy dart

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