WO2019231128A1 - Vascular anastomosis device comprising biodegradable shape memory polymer film and stent - Google Patents

Abstract

The present invention relates to a vascular anastomosis device comprising a biodegradable shape memory polymer film and a stent, and more specifically, by forming microneedles on one side of the biodegradable shape memory polymer film, the microneedles penetrate the outer wall of a blood vessel and become fixed to the blood vessel, connecting a disconnected blood vessel, and at the same time, inserting the stent into the disconnected blood vessel to maintain the structure of the connected blood vessel, so that thrombus formation and blockage of the blood vessel, which occur as the internal diameter of the blood vessel becomes narrower due to excessive proliferation of smooth muscle cells inside the blood vessel after the blood vessel is connected, can be prevented.

Description

Vascular anastomosis device including biodegradable shape memory polymer film and stent

The present invention relates to a blood vessel anastomosis device including a biodegradable shape memory polymer film and a stent, and more particularly, by forming microneedles on one surface of the biodegradable shape memory polymer film, the microneedles are fixed to blood vessels while penetrating the outer wall of the blood vessel. By connecting the cut blood vessels and simultaneously inserting a stent into the cut blood vessels to maintain the structure of the blood vessels, the blood vessels are anastomated and smooth muscle cells are excessively proliferated in the blood vessels, thereby narrowing the inner diameter of the blood vessels. The present invention relates to a blood vessel anastomosis device capable of preventing clot formation and occlusion of blood vessels.

As urbanization rapidly progresses and people's lack of exercise and eating habits become more widespread, so-called vascular obstruction is gradually increasing, which narrows or substantially blocks the blood vessels of the human body. In particular, most of the heart disease may be caused by ischemia that is blocked blood vessels that supply nutrition and oxygen to the heart, such as myocardial infarction, angina pectoris may correspond.

Surgical treatments can often be applied to treat such closed or nearly closed vessels. For example, a procedure may be used in which a site in which vascular occlusion has progressed is cut and then anastomated in the cut vessel. In addition to the treatment of such vascular obstruction, vascular anastomosis surgery may be performed at the time of organ transplantation or anastomosis of the cut blood vessel.

The cross-section of the blood vessel is mainly composed of the inner layer (intima), the middle layer (media) and the outer layer (adventitia), and when the two vessels anastomosis, the inner layers are usually in close contact with the inner layers.

In addition to the treatment of vascular obstruction of the heart as described above, microsurgical surgeons use a suture to secure the surgical field of vision using a suture during reconstructive surgery or anastomosis of cut blood vessels. Since the method of suture by hand and manual is used, such suture surgery can be performed only by highly skilled doctors, and it takes a lot of time and effort to develop such specialists.

In addition, the vascular anastomosis surgery by sutures requires the use of local flaps or free flaps for reconstruction after tissue removal surgery such as various cancer surgeries, and especially in the case of free flaps, micro anastomosis that connects blood vessels and blood vessels is essential. In the following, there is a problem such as an increase in the operation time, increase in cost, and the like.

Therefore, a number of vascular anastomosis devices have been devised to avoid suturing blood vessels directly by hand using such sutures. Among them, US Pat. No. 3,774,615, US Pat. No. 4,214,586, and US Pat. No. 4,917,087 are examples of devices that can easily perform end-to-end anastomosis of blood vessels, and US Synovis is already commercialized. There is a microvascular anastomotic coupler from the Micro Companies Alliance.

Drahoslav Lim and two others presented a device for anastomosis without surgery in a broken blood vessel in US Pat. No. 3,774,615, which does not completely fix the vessels at the site where the vessels are anastomated, but turns around the two cut vessels. It is not easy to glue evenly along the way, and because the area where the disconnected parts meet each other is too small, the anastomosis may not work properly and blood may leak.

Robert W. Mericle, in US Pat. No. 4,214,586, provided the basic principle similar to US Pat. No. 3,774,615, but with a device for well-separating broken vessel ends. However, the disadvantage of the anastomosis is not improved because the area where the disconnected portions of the blood vessels meet each other is still too small.

David J. Walsh and three others presented a fixed tubular vascular anastomosis device in US Pat. No. 4,917,087, which is an end-to-end or end-to-side ( It can be used for end-to-side anastomosis, but can only be used if the two vessels have the same diameter, and it is efficient because it has a tendency to return to the anastomosis because of the weak fixing force associated with the inner layer after anastomosis of the inner and inner layers. Can not do it.

End-to-end vascular anastomosis surgery usually involves anastomosis of blood vessels with different diameters. In the case of using conventional vascular anastomosis, a uniform design is used for various types of vessel sizes and shapes for individual and surgical sites. There are many problems to use accordingly.

In addition, in the case of most existing vascular anastomosis apparatus as described above, the surgical method uses a method of anastomizing blood vessels in a physical manner after fixing the blood vessels by eversion and fixing them to specific sites. Physical anastomosis can be performed on veins with relatively thin muscle tissue of the vessel wall due to the characteristics of blood vessels, but it is difficult to use for arteries with thick muscle tissue of the vessel wall, especially in patients with vascular diseases. The field of application is quite limited because the procedure cannot proceed.

In addition, most vascular anastomosis is composed of substances that remain semi-permanently in the human body. Therefore, when a growing patient undergoes the procedure, it is necessary to suppress the growth of blood vessels and to perform repetitive vasodilation after a certain period of time. I have a problem.

In addition, in the case of a blood vessel anastomosis device mounted on the outside of the blood vessel to perform an anastomosis, blood vessels may be disconnected so that the area of the anastomosis is too small so that anastomosis may not be properly performed and blood may leak. In addition, there is a disadvantage in that the surgery to remove the device in the future.

On the other hand, the vascular anastomosis device which is inserted into the blood vessel and performs vascular anastomosis has the advantage of being naturally decomposed and removed after a certain time because it is made of biodegradable polymer, but the blood is coagulated due to the polymer inserted into the blood vessel. In this case, the vascular endothelial cells are additionally generated due to the inserted vascular anastomosis device, thereby inducing excessive proliferation of smooth muscle cells inside the blood vessel, thereby causing narrowing of blood vessels.

[Preceding technical literature]

[Patent Documents]

(Patent Document 1) U.S. Patent No. 4,214,586 (Name: Anastomotic coupling device, Registered Date: July 29, 1980)

(Patent Document 2) US Patent No. 4,917,087 (Name: Anastomosis devices, kits and method, Registered date: April 17, 1990)

In order to solve the above problems, the present inventors can utilize various types of blood vessels according to various types of individual and surgical sites, and can easily perform anastomosis, biodegradable shape memory polymer film and stent. By using the present invention, a blood vessel anastomosis device has been invented that can be decomposed into the body after a certain period of time without additional device removal surgery and at the same time prevent the narrowing of blood vessels caused by anastomosis.

Accordingly, it is an object of the present invention to provide a blood vessel anastomosis device comprising a biodegradable shape memory polymer film and a stent.

In order to achieve the above object, the blood vessel anastomosis device according to an embodiment of the present invention comprises a biodegradable shape memory polymer film and stent, wherein the biodegradable shape memory polymer film has a plurality of micro-needle (micro-needle) on one surface It is formed, the stent has a shape that can be inserted into the blood vessel is made of a shape memory polymer.

The biodegradable shape memory polymer film may be a polymer material whose shape is modified according to temperature change. In addition, the biodegradable shape memory polymer film may cover the outer wall of the blood vessel to prevent the separation of the blood vessel bonded.

The biodegradable shape memory polymer film may have holes formed therein. Here, the diameter of the hole may be 10 to 1000㎛.

The stent may be made of a shape memory polymer using temperature rise as an energy source of deformation, and may be deformed into an original shape, a temporary shape, or a permanent shape. In addition, the stent may be biodegradable.

The vascular anastomosis device according to the present invention uses a biodegradable material, so that the device is decomposed in the body over time and does not require additional surgery to remove the device, thereby increasing the convenience of surgery and a better effect on the health of the patient. It can have

In addition, the blood vessel anastomosis device according to the present invention includes a biodegradable shape memory polymer film formed on one surface of the microneedle, thereby connecting the blood vessels cut using the microneedle and preventing the blood vessels from being detached, and the microneedle vessel By causing artificial damage through the outer wall of the blood vessels due to the excessive growth of the smooth muscle cells (Smooth muscle cells) due to the narrowing of the inner diameter of the blood vessels can be prevented clot formation and blood vessel closure.

In addition, the blood vessel anastomosis device according to the present invention includes a stent, thereby maintaining the structure of the blood vessel by applying the stent inside the blood vessel.

In addition, the blood vessel anastomosis device according to the present invention includes a biodegradable shape memory polymer film and a stent, thereby maximizing the cross-sectional area of the blood vessel to be bonded to increase the bonding force, it is possible to achieve a stable vessel bonding.

1 and 2 are a cross-sectional view and a front view of the blood vessel anastomosis device according to one embodiment of the present invention applied to blood vessels.

3 and 4 are cross-sectional views and plan views of the biodegradable shape memory polymer film shown in FIGS. 1 and 2.

5 and 6 are views showing the expected intravascular reaction process after applying the blood vessel anastomosis device shown in FIGS. 1 and 2 to the blood vessel.

7 to 10 are views schematically illustrating a process in which the blood vessel anastomosis device shown in FIGS. 1 and 2 is inserted between the cut blood vessels and thus the blood vessel anastomosis is performed.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. Like parts are designated by like reference numerals throughout the specification.

1 and 2 is a view showing a blood vessel anastomosis device according to an embodiment of the present invention to blood vessels, Figure 1 is a cross-sectional view, Figure 2 is a front view.

1 and 2, the blood vessel anastomosis device according to the present invention includes a biodegradable shape memory polymer film 10 and a stent 30 to connect both ends of the cut blood vessel 20.

The shape memory referred to in the present invention refers to a property in which a processed object is broken or changed in shape, and when a certain condition is satisfied, the original shape is stored and returned.

As used herein, the term "biodegradability" refers to a property in which an object decomposes over time in a chemical environment.

3 and 4 are cross-sectional views and plan views of the biodegradable shape memory polymer film shown in FIGS. 1 and 2.

As shown in Figure 3 and 4, the biodegradable shape memory polymer film 10 is made of a film form, has a flexibility can be transformed into a shape that covers the outer wall surrounding the vessel.

In addition, the biodegradable shape memory polymer film 10 is to connect the cut blood vessels to surround the blood vessel outer wall with the biodegradable shape memory polymer film 10 and to fix it in this state (micro-needle) (10a) Penetrate the outer wall of the vessel with) to fix the vessels in the bonded state.

More specifically, the biodegradable shape memory polymer film 10 may have a plurality of microneedles 10a formed on one surface thereof, and specifically, the biodegradable shape memory polymer film 10 is wrapped around the blood vessel outer periphery. As a result, the microneedle 10a penetrates the outer wall of the blood vessel and is firmly fixed to the outer peripheral edge of the blood vessel.

In addition, as described above, the microneedle 10a may be artificially damaged by penetrating the outer wall of the blood vessel. Artificial damage of the microneedle (10a) can prevent the closing of the blood vessels caused by narrowing the inner diameter of the blood vessels due to excessive proliferation of blood clots and smooth muscle cells generated when the stent is inserted into the blood vessels Has an effect. 5 and 6, which illustrate the expected intravascular reaction process after applying the blood vessel anastomosis device shown in FIGS. 1 and 2 to the blood vessel, for more detailed description.

Generally, as shown in FIG. 5, when the stent 30 is inserted into a blood vessel, vascular endothelial cells are damaged to cause abnormal proliferation of smooth muscle cells, thereby increasing the thickness of the inner wall of the blood vessel and causing vascular narrowing. On the other hand, by wrapping the biodegradable shape memory polymer film 10 having the microneedle 10a according to the present invention along the outer circumference of the blood vessel as shown in FIG. 6, the microneedle 10a penetrates the outer wall of the blood vessel to insert the stent 30. Due to the abnormal growth of smooth muscle cells can control the direction of cell migration to the outer vessel wall. That is, the microneedle 10a wounds the outer wall of the blood vessel and artificially induces the movement of the smooth muscle cell to the outside of the blood vessel, thereby inhibiting excessive proliferation of thrombus and smooth muscle cells generated when inserted into the blood vessel, thereby narrowing the inner diameter of the blood vessel. It has the effect of preventing the occlusion of blood vessels that occur.

In addition, the microneedle (10a) is a biodegradable polymer material that is decomposed in the human body over time and absorbed by the human body, for example, poly (L-lactide) (PLLA), poly (D, L -lactide) (PLA), poly (glycolide) (PGA), poly (L-lactide-co-D, L-lactide) (PLLA / PLA), poly (l-lactide-co-glycolide) (PLLA / PGA), poly (D, L-lactide-co-glycolide) (PLA / PGA), poly (glycolide cotrimethylene carbonate) (PGA / PTMC), polydioxanone (PDS), Polycaprolactone (PCL) , Polyhydroxybutyrate (PHBT), poly (phosphazene) poly (D, Llactide-co-caprolactone) PLA / PCL), poly (glycolide-co-caprolactone) (PGA / PCL) and copolymers thereof or It can select from these combinations, and can use.

Here, the number, length, angle, and pattern of the microneedle 10a may be set in various ways according to the respective cases required for vascular anastomosis, and the number, length, angle, and pattern of the microneedle 10a may be changed as needed. Of course, it can be set.

The biodegradable shape memory polymer film 10 is a polymer material whose shape is changed according to temperature change, and is a polyester-based polymer, polyphosphazenes, polyanhydrides, polyacetals, poly (ortho esters), polyphosphoesters, polyglycolide, Poly (ε-caprolactone), polyurethanes, polylactide, polycarbonates, polyamides can be selected from one or a combination thereof, and the polymer exhibiting the shape memory function by the moisture, a hydroxyl group (-OH functional group) Hydrogel-based polymers including polyvinyl alcohol (PVA), chitosan (chitosan), or polyethylene glycol (PEG) may be used.

At this time, the biodegradable shape memory polymer film 10, the transition temperature is preferably 39 ℃ to 55 ℃.

That is, the biodegradable shape memory polymer film 10 has a function of exerting a shape memory function by temperature, thereby giving an external deformation of a blood vessel anastomosis device rather than a physical deformation of blood vessels, thereby allowing blood flow to occur according to physical deformation of blood vessels. Minimize the various causes that can adversely affect the anastomosis, and even when anastomosis of blood vessels of different shapes and sizes, the shape can be modified to an appropriate size according to the inner diameter of each blood vessel, so that various types of individual and surgical parts Can be used depending on the size and shape of the vessel.

The biodegradable shape memory polymer film 10 is made of a biodegradable polymer that is biodegradable and decomposed over time in the human body. Examples of the biodegradable polymer include poly (L-lactide) (PLLA) and poly (D, L-lactide) (PLA), poly (glycolide) (PGA), poly (L-lactide-co-D, L-lactide) (PLLA / PLA), poly (l-lactide-co-glycol) Ride) (PLLA / PGA), Poly (D, L-lactide-co-glycolide) (PLA / PGA), Poly (glycolide cotrimethylene carbonate) (PGA / PTMC), Polydioxanone (PDS), Polycaprolactone (PCL), polyhydroxybutyrate (PHBT), poly (phosphazene) poly (D, Llactide-co-caprolactone) PLA / PCL), polycoglycolide-co-caprolactone (PGA / PCL) and their aerials It can be selected and used in one or a combination thereof.

As described above, the biodegradable shape memory polymer film 10 has biodegradability, thereby inhibiting the growth of blood vessels when the growth stage patient is subjected to a procedure using a vascular anastomosis device composed of substances that remain semi-permanently in the human body. After a certain period of time can be solved the problem of proceeding repetitive vasodilation, and additional surgery to remove the device is not necessary because it increases the convenience of surgery and can have a better effect on the health of the patient.

The biodegradable shape memory polymer film 10 is made of a film form, it can be easily applied in utilizing in various types of blood vessel size and shape.

At this time, the thickness of the biodegradable shape memory polymer film 10 is 100 to 1000㎛, preferably 300 to 700㎛, more preferably 450 to 550㎛. If the thickness within the range is used, it is easy to apply to blood vessels of various sizes and shapes. In addition, by controlling the thickness of the biodegradable shape memory polymer film 10 can be adjusted to maintain the time in the body and to control the mechanical strength.

3 and 4, the biodegradable shape memory polymer film 10 may be formed with a hole (10b), the physical motion of the blood vessel by wrapping the blood vessel outer wall of the biodegradable shape memory polymer film (10) Since the blood vessel self-renewal ability can be reduced, the biodegradable shape memory polymer film 10 has an effect of maintaining the regeneration ability of blood vessels by forming holes 10b.

In this case, the diameter of the hole (10b) may be 10 to 1000㎛, preferably 100 to 300㎛, more preferably 150 to 250㎛, but is not limited thereto.

The stent 30 has a shape that can be inserted into a blood vessel and may be made of a shape memory polymer. In this case, the shape memory polymer means using the temperature rise as the energy source of the shape deformation.

In addition, the stent 30 may be made of a shape memory polymer to be deformed into an original shape, a temporary shape, or a permanent shape.

The stent 30 made of the shape memory polymer according to the present invention is deformed sequentially into a circular stent 30, a temporary stent 30, a permanent stent 30.

In more detail, the circular stent 30 is elongated when mechanical force is applied to both sides at the transition temperature of the shape memory polymer in a circular shape immediately after being manufactured, and thus the outer diameter is reduced. Is transformed into).

And, the temporary stent 30 of the deformed form is fixed to the stent 30 of the temporary form when the temperature is gradually reduced, and again applied to a temperature above the transition temperature of the shape-memory polymer stent of the temporary form that was transformed into mechanical energy ( 30 is to be transformed into a permanent stent (30).

Since the stent 30 is made of a shape memory polymer, the flexibility is high, so the shape is easily deformed according to the movement of the bronchus, and thus the stability after the procedure is high.

The stent 30 may be manufactured according to the size and shape of blood vessels, and may be modified to fit the size and shape of blood vessels after the procedure, thereby allowing a custom procedure that is suitable for each patient's blood vessels.

The stent 30 may be manufactured by restoring the original shape of the blood vessel and adjusting it to a physical strength that can be fixed in response to fluidly changing blood vessel internal pressure, thereby reducing the pressure applied to the inner wall of the blood vessel.

Since the stent 30 is made of a shape memory polymer, the stent 30 is restored to its own shape by body temperature after being inserted into the lumen, thereby simplifying the procedure and greatly shortening the overall procedure time. In this case, as an example of the shape memory polymer, poly-norbornene, poly-isoprene, styrene-butadiene copolymer, polyurethane (poly-urethane), polyethylene (poly-ethylene) ), But is not limited to polyester (polyester) polymer. Examples of polyester-based shape memory polymers include polyphosphazene, polyanhydride, polyacetal, poly-ortho ester, polyphosphoester and polyglycol. It may be selected from one or a combination of polyglycolide, poly-ε-caprolactone, polylactide, polycarbonate, polyamide, but is not limited thereto. no. Preferably, poly (glycerol-sebacate) -stearate] or polycaprolactone-glycidyl methacrylate [Poly (caprolactone-glycidylmethacrylate) that is easy to deform in consideration of the vascular internal environment. )] Can be used as a shape memory polymer.

The stent 30 may be biodegradable, and may be made of a biodegradable polymer that is decomposed and absorbed over time in the human body. Examples of the biodegradable polymer include poly (L-lactide) (PLLA) and poly (D). , L-lactide) (PLA), poly (glycolide) (PGA), poly (L-lactide-co-D, L-lactide) (PLLA / PLA), poly (l-lactide-co-glycolide) (PLLA / PGA), poly (D, L-lactide-co-glycolide) (PLA / PGA), poly (glycolide cotrimethylene carbonate) (PGA / PTMC), polydioxanone (PDS), Polycaprolactone ( PCL), polyhydroxybutyrate (PHBT), poly (phosphazene) poly (D, Llactide-co-caprolactone) PLA / PCL), polycoglycolide-co-caprolactone (PGA / PCL) and copolymers thereof It can be selected and used in one or a combination of these.

The stent 30 may be a mesh-like structure, and by having a mesh-like structure, the stent 30 may minimize a blood clot generated by insertion into the blood vessel.

In this case, the mesh structure means that a network shape is formed so that a plurality of holes are formed.

Hereinafter, a process of changing the shape of the vascular anastomosis device according to an embodiment of the present invention and a process of vascular anastomosis using the vascular anastomosis device according to the present invention will be briefly described with reference to FIGS. 7 to 10.

First, in order to insert the stent 30 of the initial circular shape (original shape) into the cut blood vessel 20, as shown in FIG. 8, the stent 30 is elongated to extend the stent 30 to a temporary shape. After transformation into the vessel 20 is inserted. Then, while gradually increasing the temperature while maintaining the stent 30 temporary form (wherein the increased temperature is increased to a temperature of about 20 ~ 40 ℃), the stent 30 is fixed in a temporary form, As shown in FIG. 9, heat is applied again to a temperature above the transition temperature, so that the stent 30 is restored to an initial circular shape before being deformed by mechanical force to maintain a permanent shape. Accordingly, the first cut blood vessels are anastomated and fixed so as not to reduce the inner diameter of the blood vessels.

Next, as shown in FIG. 10, the microdegradable microneedle 10a may be elongated by applying mechanical force to both sides of the biodegradable shape-memory polymer film 10 having an initial shape (transition temperature) at or below a transition temperature. ) Is transformed into a temporary shape by wrapping the outer wall of the blood vessel 20 so as to contact the outer wall of the blood vessel 20.

At this time, the microneedle (10a) of the biodegradable shape memory polymer film 10 passes through the outer wall of the vessel 20, while the biodegradable shape memory polymer film 10 is fixed to the vessel 20, the temporary form By gradually increasing the temperature while maintaining (wherein the increased temperature is increased to a temperature of about 20 ~ 40 ℃), the biodegradable shape memory polymer film 10 is fixed in a temporary form, and again the temperature above the transition temperature When the heat is applied, the biodegradable shape memory polymer film 10 is restored to an initial circular shape before being deformed by mechanical force to maintain a permanent shape. As a result, secondary vascular anastomosis is achieved to achieve excellent and stable vascular anastomosis.

That is, by inserting the stent 30 inside each vessel between the two vessels cut so as not to shrink the vessel diameter, the biodegradable shape memory polymer film 10 as one band for bonding the two vessels After stretching by applying mechanical force to both sides, the biodegradable shape memory polymer film 10 is deformed to cover the outer wall of the blood vessel and fixed in the temporary form, and then the temperature is raised to a temperature higher than the transition temperature so that the biodegradable shape memory The polymer film 10 is contracted to reduce its outer diameter, and the outer circumferential surface of the biodegradable shape memory polymer film 10 is adhered to the cut outer wall of the blood vessel to be fixed in the permanent form, thereby achieving vascular anastomosis.

Vascular anastomosis device according to the present invention includes the biodegradable shape memory polymer film 10 and the stent 30 together, thereby maximizing the cross-sectional area of the blood vessel to be bonded to increase the bonding force, it is possible to achieve a stable blood vessel junction.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concepts of the present invention defined in the following claims are also provided. It belongs to the scope of rights.

[Description of the code]

10: biodegradable shape memory polymer film

10a: microneedle

10b: hall

20: blood vessel

30: stent

The present invention relates to a blood vessel anastomosis device including a biodegradable shape memory polymer film and a stent, and more particularly, by forming microneedles on one surface of the biodegradable shape memory polymer film, the microneedles are fixed to blood vessels while penetrating the outer wall of the blood vessel. By connecting the cut blood vessels and inserting a stent into the cut blood vessels at the same time to maintain the structure of the bonded blood vessels, the blood vessels are anastomated and smooth muscle cells are excessively proliferated in the blood vessels, thereby narrowing the inner diameter of the blood vessels. Thrombus formation and occlusion of blood vessels that occur may be prevented.

Claims (7)

In the blood vessel anastomosis device for connecting both ends of the cut blood vessel, The vascular anastomosis device includes a biodegradable shape memory polymer film and stent, The biodegradable shape memory polymer film has a plurality of micro-needle (micro-needle) is formed on one surface, The stent has a shape that can be inserted into the blood vessel and a blood vessel anastomosis device that is made of a shape memory polymer. The method of claim 1, The biodegradable shape memory polymer film Vascular anastomosis device, characterized in that the polymer material is deformed according to temperature changes. The method of claim 1, The biodegradable shape memory polymer film is vascular anastomosis device, characterized in that to cover the outer wall of the blood vessel to prevent the separation of the blood vessels bonded. The method of claim 1, The biodegradable shape memory polymer film is vascular anastomosis device, characterized in that the hole is formed. The method of claim 4, wherein The diameter of the hole is a blood vessel anastomosis device, characterized in that 10 to 1000㎛. The method of claim 1, The stent is made of a shape memory polymer that uses the temperature rise as an energy source of shape deformation, and thus can be transformed into an original shape, a temporary shape, or a permanent shape. Device. The method of claim 1, The stent is vascular anastomosis device, characterized in that the biodegradable.

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