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WO2019228946A1 - Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé - Google Patents

Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé Download PDF

Info

Publication number
WO2019228946A1
WO2019228946A1 PCT/EP2019/063575 EP2019063575W WO2019228946A1 WO 2019228946 A1 WO2019228946 A1 WO 2019228946A1 EP 2019063575 W EP2019063575 W EP 2019063575W WO 2019228946 A1 WO2019228946 A1 WO 2019228946A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
nozzle
assembly
adapter
spray device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/063575
Other languages
English (en)
Inventor
Marcus Söderlund
Nils Ronquist
Wilhelmus Petrus Johannes De Kruijf
Wietze Nijdam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHL Medical AG
Original Assignee
SHL Medical AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHL Medical AG filed Critical SHL Medical AG
Publication of WO2019228946A1 publication Critical patent/WO2019228946A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/14—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openings; with strainers in or outside the outlet opening

Definitions

  • the present disclosure generally relates to spray devices.
  • an assembly for a spray device a spray device comprising an assembly, a medicament delivery device comprising an assembly or a spray device, and a method of providing an assembly for a spray device, are provided.
  • Spray devices comprising a micro nozzle form an increasingly important and growing segment of the market.
  • Micro nozzles may for instance be found in inkjet printing appliances, 3D printers, perfume containers and medicament delivery devices.
  • the containers e.g. syringes or cartridges
  • the user When the contents of the container are spent, the user either has to throw away the whole spray device, or at least the cartridge holder. It would be of interest to be able to assemble the nozzle with the container/cartridge so that the user may easily replace spent cartridges and nozzles in the spray device, without unnecessary waste.
  • a problem that may arise then is the sterilization of the cartridge-nozzle assembly.
  • WO 2014111370 Ai discloses a medicament delivery device for delivering metered doses of medicament.
  • An indicator mechanism is operably connected to a drive member and arranged to visibly indicate to a user of the device when a spring force tensioning member has been operated such that the device is ready for dose delivery.
  • One object of the present disclosure is to provide an assembly for a spray device, which assembly enables a reduction of waste.
  • a further object of the present disclosure is to provide an assembly for a spray device, which assembly enables simple attachment/detachment to/from the spray device.
  • a still further object of the present disclosure is to provide an assembly for a spray device, which assembly enables effective sterilization of the assembly.
  • a still further object of the present disclosure is to provide an assembly for a spray device, which assembly has a simple and/or cheap design.
  • a still further object of the present disclosure is to provide an assembly for a spray device, which assembly solves several or all of the foregoing objects in combination.
  • a still further object of the present disclosure is to provide a spray device solving one, several or all of the foregoing objects.
  • a still further object of the present disclosure is to provide a medicament delivery device solving one, several or all of the foregoing objects.
  • a still further object of the present disclosure is to provide a method of providing an assembly for a spray device, which method solves one, several or all of the foregoing objects.
  • an assembly for a spray device comprising a nozzle; a cartridge for holding a liquid to be pressurized and pushed through the nozzle to form an aerosol; and a cartridge adapter fixed to the cartridge and arranged to hold the nozzle in position relative to the cartridge.
  • the assembly may be referred to as a nozzle and cartridge assembly or a cartridge-nozzle assembly.
  • the cartridge adapter fixedly holding the cartridge and the nozzle, the assembly comprising the cartridge, the cartridge adapter and the nozzle can be sterilized, delivered, attached to the spray device, and detached from the spray device, as a single unit.
  • the nozzle may be mounted in the cartridge adapter.
  • the nozzle may for example be provided in a nozzle adapter which in turn is connected to the cartridge adapter.
  • the nozzle may be directly mounted in the cartridge adapter, i.e. without any dedicated nozzle adapter.
  • the cartridge adapter may be fixed to the cartridge by means of a luer lock
  • the cartridge may comprise a neck and the cartridge adapter may be fixed to the neck of the cartridge.
  • the cartridge adapter may comprise a female luer taper (or cone) and the neck of the cartridge may comprise, or constitute, a male luer taper (or cone) for engagement with the female luer taper.
  • the neck of the cartridge may comprise a neck flange and the cartridge adapter may be configured to engage the neck flange.
  • the cartridge adapter may comprise a lock ring configured to engage the neck flange.
  • the lock ring may comprise a lock ring collar configured to engage a distal side of the neck flange.
  • the neck flange and/or the lock ring collar may be circular.
  • the neck flange may extend in a plane substantially perpendicular to, or perpendicular to, a longitudinal axis of the cartridge.
  • the nozzle may be a micro nozzle.
  • the assembly may comprise a nozzle that is not necessarily a micro nozzle.
  • the nozzle may alternatively be referred to as a chip.
  • the assembly may further comprise a nozzle adapter comprising the nozzle.
  • the nozzle adapter may be configured to be fit in the cartridge adapter.
  • the nozzle adapter may form part of the cartridge adapter.
  • the cartridge adapter may for example comprise an outer cap and the nozzle adapter may be press-fitted into the outer cap.
  • the nozzle may for example be press-fitted into the nozzle adapter.
  • the nozzle adapter may be molded around the nozzle. The nozzle adapter and the nozzle form a spray nozzle unit assembled with the cartridge by means of the cartridge adapter.
  • the cartridge adapter may be made of a material transparent to sterilization gas.
  • the cartridge adapter may be made of one or more materials transparent to ethylene oxide (ETO) gas.
  • ETO ethylene oxide
  • the cartridge adapter may be assembled from multiple molded components. Alternatively, the cartridge adapter may be made in one piece. In any case, the cartridge adapter may be made of plastic, rubber, or various combinations thereof.
  • the cartridge adapter is made of one or more thermoplastic elastomer materials.
  • the cartridge adapter comprises the nozzle adapter, an outer cap, an inner cap and a lock ring.
  • the nozzle adapter may be press- fitted into the outer cap.
  • the unit comprising the nozzle adapter and the outer cap may be connected to the inner cap, e.g. such that the outer cap is positioned around the inner cap and such that the nozzle adapter is positioned proximal of the inner cap.
  • the outer cap may comprise an outer cap recess and the inner cap may comprise an inner cap flange configured to engage the outer cap recess to thereby connect the outer cap to the inner cap.
  • the inner cap may comprise an inner cap recess and the outer cap may comprise an outer cap flange configured to engage the inner cap recess.
  • the lock ring may then be connected to the unit comprising the nozzle adapter, the outer cap and the inner cap.
  • the lock ring may for example be connected to the outer cap, e.g. such that the lock ring is positioned distal of, or in a distal region of, the outer cap.
  • the lock ring may comprise a lock ring recess and the outer cap may comprise an outer cap flange configured to engage the lock ring recess to thereby connect the outer cap to the lock ring.
  • the cartridge adapter comprising the nozzle adapter, the outer cap, the inner cap and the lock ring, may then be connected to the cartridge.
  • the inner cap may comprise a female luer taper (or cone) and the neck of the cartridge may comprise, or constitute, a male luer taper (or cone) for engagement with the female luer taper
  • the lock ring may comprise a lock ring collar configured to engage a distal side of the neck flange.
  • the cartridge may be filled with liquid.
  • the cartridge may for example have a maximum volume of 0.5 ml to 3 ml.
  • a spray device comprising an assembly according to the present disclosure.
  • the spray device may further comprise a dispenser unit.
  • the cartridge adapter may be arranged to hold the nozzle in position relative to the dispenser unit.
  • the assembly may be detachably connectable to the dispenser unit.
  • the spray device may further comprise a cartridge holder connected to the dispenser unit.
  • the assembly may be detachably connectable to the cartridge holder.
  • the assembly may be detachably connectable to the cartridge holder in various ways, for example by means of a snap-fit.
  • the cartridge holder may be permanently connected to the dispenser unit. Thus, the cartridge holder can be used multiple times. Consequently, the waste is reduced.
  • a medicament delivery device comprising an assembly according to the present disclosure or a spray device according to the present disclosure.
  • a method of providing an assembly for a spray device comprising mounting a nozzle in a cartridge adapter; and connecting the cartridge adapter to a cartridge by connecting a luer lock of the cartridge adapter to a neck of the cartridge.
  • the method may further comprise filling the cartridge with liquid prior to connecting the cartridge adapter to the cartridge.
  • the method may further comprise providing the nozzle in a nozzle adapter, connecting the nozzle adapter to an outer cap (for example by press fitting), connecting an inner cap to the outer cap, and connecting a lock ring to the outer cap to form the cartridge adapter prior to connecting the cartridge adapter to the cartridge.
  • the method may further comprise sterilizing the assembly prior to connecting the assembly to a spray device.
  • distal when the term “distal” is used, this refers to the direction pointing away from the dose delivery site.
  • distal part/end this refers to the part/end of the spray device, or the parts/ends of the members thereof, which under use of the spray device is/are located furthest away from the dose delivery site.
  • proximal when the term “proximal” is used, this refers to the direction pointing to the dose delivery site.
  • proximal part/end when the term “proximal part/end” is used, this refers to the part/end of the spray device, or the parts/ends of the members thereof, which under use of the spray device is/are located closest to the dose delivery site.
  • Fig. la shows a perspective view of a dispenser unit of a spray device
  • Fig. lb shows a cross-sectional view of a spray device comprising a micro nozzle assembled with the dispenser unit and a cartridge for spray liquid;
  • Fig. IC shows a conceptual view of a proximally facing outlet side of the micro nozzle
  • Fig. id shows a conceptual view of a distally facing inlet side of the micro nozzle
  • Fig. 2 shows a perspective cross-sectional view of an assembly
  • Fig. 3 shows a cross-sectional side view of the assembly.
  • Fig. la shows a perspective view of an exemplary embodiment of a dispenser unit 20 of a spray device.
  • the dispenser unit 20 has a proximal side 22, through which an aerosol is sprayed, and a distal side 24, which is mounted on the spray device.
  • the dispenser unit 20 is a mouthpiece of an inhalation spray device, which is one of many types of medicament delivery devices according to the present disclosure.
  • Many other types of dispenser units 20, for any application requiring a very fine aerosol, are conceivable.
  • Other examples include eye spray devices and perfume dispensers, to name but a few.
  • Fig. lb shows a cross-sectional view of the spray device 26 comprising a micro nozzle 50 assembled with the dispenser unit 20 and a cartridge 35 for spray liquid.
  • the spray device 26 comprises the dispenser unit 20, a cartridge holder 30, the micro nozzle 50, the cartridge 35 and a cartridge adapter 38.
  • the micro nozzle 50 is mounted in the dispenser unit 20. Although a micro nozzle 50 is shown in Fig. lb, a nozzle 50 according to the present disclosure does not necessarily have to be a micro nozzle.
  • the cartridge 35 is filled with a liquid to be sprayed.
  • the cartridge 35 may be made of glass.
  • the cartridge 35 may for example have a maximum volume of 0.5 ml to 3 ml.
  • the cartridge 35 comprises a neck 37.
  • the term cartridge is herein used interchangeably with the terms container and syringe. All three terms are herein defined as denoting a vessel containing, or suitable for containing, a liquid.
  • the cartridge 35, the cartridge adapter 38 and the micro nozzle 50 form an assembly 32 for the spray device 26.
  • the assembly 32 thus comprises the cartridge 35 containing a liquid to be pressurized, the micro nozzle 50 for producing an aerosol from the expelled pressurized liquid, and the cartridge adapter 38.
  • the micro nozzle 50 is permanently attached to the cartridge 35 before, or in conjunction with filling of the cartridge 35 with a liquid to be sprayed.
  • the cartridge holder 30 is connected to the dispenser unit 20. As shown in Fig. lb, the cartridge 35 is positioned within the cartridge holder 30.
  • the cartridge 35 is fixedly assembled with the cartridge adapter 38 and the micro nozzle 50.
  • the cartridge 35 thus holds a liquid which is to be pressurized and pushed through the micro nozzle 50 to form an aerosol.
  • the cartridge adapter 38 is arranged to hold the micro nozzle 50 in position relative to the cartridge 35.
  • the cartridge adapter 38 is also arranged to hold the micro nozzle 50 in position relative to the dispenser unit 20.
  • the micro nozzle 50 is mounted in the cartridge adapter 38.
  • the assembly 32 further comprises a luer lock 28.
  • the luer lock 28 comprises a female luer taper formed in the cartridge adapter 38 and a male luer taper formed by the cartridge 35.
  • the male luer taper is formed by the neck 37 of the cartridge 35.
  • the cartridge adapter 38 may be fixed to the cartridge 35, such as by the luer lock coupling, when the cartridge 35 has been filled with liquid. The micro nozzle 50 is thus attached to the cartridge 35 via the luer lock 28.
  • An end user can receive a number of assemblies 32 of cartridges 35 fitted with cartridge adapters 38.
  • An assembly 32 including a cartridge 35, a cartridge adapter 38 and a micro nozzle 50 can then be placed in the spray device 26 with the dispenser unit 20.
  • the assembly 32 is connected to the cartridge holder 30, for example by means of a snap-fit connection.
  • the assembly 32 can easily be connected/disconnected to/from the cartridge holder 30.
  • the assembly 32 can be manually detached from the cartridge holder 30 while the cartridge holder 30 remains attached to the dispenser unit 20. Thereby, the amount of waste is reduced.
  • Fig. lc shows a conceptual view of a proximally facing outlet side 52 of the micro nozzle 50 and Fig. id shows a conceptual view of a distally facing inlet side 54 of the micro nozzle 50.
  • the micro nozzle 50 comprises a plurality of orifices.
  • Fig. lc shows outlet orifices 57 on the proximal outlet side 52 of the micro nozzle 50.
  • Fig. id shows inlet orifices 59 on the distal inlet side 54 of the micro nozzle 50.
  • the micro nozzle 50 comprises a ceramic or a monocrystalline material, such as a semiconductor material, which is suitable for micro-structure processing.
  • a micro nozzle 50 is herein defined as a nozzle having orifice diameters between 0.5 pm and 10 pm, which may produce an aerosol of very fine droplets by pressurizing a liquid on the inlet side 54 of the micro nozzle 50, which liquid is expelled as droplets at an outlet side 52 of the micro nozzle 50.
  • Droplet diameters may be approximately 1 pm in the lower range of orifice diameters. Depending on viscosity, pressure and orifice diameters, the expelled liquid may form into Rayleigh droplet trains.
  • the micro nozzle 50 has at least one orifice on the inlet side 54 and at least one orifice on the outlet side 52.
  • the inlet orifices 59 and the outlet orifices 57 are connected inside the micro nozzle 50 by cavities and/or channels.
  • the channels and orifices are not essential in themselves for this disclosure. However, as shown in Figs lc and id, it is customary to provide a larger number of orifices on the inlet side 54 than on the outlet side 52 because the orifices are normally formed in membranes which cover a cavity, or channel, in the micro nozzle 50. It is therefore preferable to have a smaller pressure drop on the inlet side 54 than on the outlet side 52.
  • Fig. 2 shows a perspective cross-sectional view of an assembly 32 comprising the cartridge adapter 38 and a nozzle adapter 70 assembled with the cartridge 35.
  • the cartridge adapter 38 holds the nozzle adapter 70.
  • the nozzle adapter 70 comprises the micro nozzle 50. Since different kinds of cartridges 35 may be required for different spray device applications, the nozzle adapter 70 may have a universal design configured to be fit in cartridge adapters 38 of different designs.
  • the micro nozzle 50 is provided in the nozzle adapter 70.
  • the micro nozzle 50 may for example be mounted in the nozzle adapter 70 at the proximal end of the nozzle adapter 70.
  • the micro nozzle 50 may for example be press-fitted into the nozzle adapter 70.
  • a micro sieve chip and/or a pre-filter may also be provided in the nozzle adapter 70, distal of the micro nozzle 50.
  • the nozzle adapter 70 and the micro nozzle 50 form a spray nozzle unit assembled with the cartridge 35 by means of the cartridge adapter 38.
  • the cartridge adapter 38 is permanently assembled from multiple molded components.
  • monolithic cartridge adapters 38 are also envisaged.
  • a cartridge adapter 38 which is permanently attached to the cartridge 35 should allow for sterilization of all necessary surfaces of the assembly 32.
  • the material of the cartridge adapter 38 should be selected to be transparent to sterilization gas, e.g. selected from ethylene oxide (ETO) transparent materials, so that the sterilizing gas is able to reach all areas of the assembly 32.
  • ETO ethylene oxide
  • Fig. 3 shows a cross-sectional side view of the assembly 32.
  • Fig. 3 further shows a longitudinal axis 74 of the cartridge 35.
  • the cartridge adapter 38 is assembled from a plurality of components.
  • the cartridge adapter 38 comprises a lock ring 42, an outer cap 44, an inner cap 46 and the nozzle adapter 70 in which the micro nozzle 50 is arranged.
  • the micro nozzle 50 is thus provided in the nozzle adapter 70 which in turn is connected to the cartridge adapter 38.
  • the inner cap 46 comprises a female luer taper forming one part of the luer lock 28.
  • the neck 37 of the cartridge 35 comprises a male luer taper for engagement with the female luer taper.
  • the neck 37 of the cartridge 35 thereby forms the other part of the luer lock 28.
  • the lock ring 42, the outer cap 44, the inner cap 46 and the nozzle adapter 70 are molded independently and then assembled to form the cartridge adapter 38.
  • the lock ring 42, the outer cap 44, the inner cap 46 and the nozzle adapter 70 may be made of one or more materials transparent to sterilization gas.
  • the nozzle adapter 70 may for example be made of a thermoplastic material transparent to sterilization gas.
  • the lock ring 42 comprises a lock ring collar 72 and a lock ring recess 68.
  • the lock ring collar 72 is generally circular and extends radially inwards with respect to the longitudinal axis 74 in the mounted state of the assembly 32.
  • the outer cap 44 comprises an outer cap recess 64 and an outer cap flange 66.
  • the outer cap recess 64 faces radially inwards with respect to the longitudinal axis 74 in the mounted state of the assembly 32.
  • the outer cap flange 66 protrudes radially outwards with respect to the longitudinal axis 74 in the mounted state of the assembly 32.
  • the outer cap 44 comprises a through opening (along the longitudinal axis 74) for receiving the nozzle adapter 70.
  • the inner cap 46 comprises an inner cap flange 62.
  • the inner cap flange 62 protrudes radially outwards with respect to the longitudinal axis 74 in the mounted state of the assembly 32.
  • the inner cap 46 comprises a through opening (along the longitudinal axis 74) for receiving a proximal tip of the neck 37 of the cartridge 35.
  • the cartridge 35 comprises a neck flange 48 formed on the neck 37.
  • the neck flange 48 is generally circular and protrudes radially outwards, with respect to the longitudinal axis 74, from the neck 37.
  • the cartridge adapter 38 is configured to engage the neck flange 48.
  • the cartridge 35 is filled with a liquid to be dispensed, such as a medical liquid.
  • a liquid to be dispensed such as a medical liquid.
  • the material of the nozzle adapter 70 may be heated and the micro nozzle 50 may be pushed into the nozzle adapter 70 while heated.
  • the nozzle adapter 70 comprising the micro nozzle 50 is then connected into the outer cap 44 by an irreversible press fit.
  • the outer cap 44 is thus a holder for the nozzle adapter 70.
  • the outer cap 44 is slightly flexible.
  • the inner cap 46 is then connected to the outer cap 44. To this end, the inner cap 46 is pushed into the outer cap 44 until the inner cap flange 62 is seated in the outer cap recess 64. The outer cap 44 is thereby positioned around the inner cap 46.
  • the outer cap 44, the inner cap 46 and the nozzle adapter 70 have thereby been connected to form a sub-assembly.
  • This sub-assembly is then clicked into the lock ring 42. More specifically, this sub-assembly is moved such that the inner cap 46 and the outer cap 44 extend partly into the lock ring 42 and until the outer cap flange 66 becomes seated in the lock ring recess 68.
  • the cartridge adapter 38 comprising the nozzle adapter 70 with the micro nozzle 50, the inner cap 46, the outer cap 44 and the lock ring 42 has thereby been formed.
  • the cartridge adapter 38 is then mounted to the cartridge 35 to form the assembly 32.
  • the cartridge adapter 38 is pushed as a unit over the neck 37 of the cartridge 35 until the lock ring collar 72 snaps over the neck flange 48.
  • the lock ring collar 72 is thereby positioned at a distal side of the neck flange 48.
  • the female luer taper of the inner cap 46 sealingly mates with the male luer taper constituted by the neck 37.
  • the luer lock 28 is positioned at a proximal side of the neck flange 48.
  • the cartridge adapter 38 and the micro nozzle 50 are thereby connected to the cartridge 35 by means of the luer lock 28.
  • the assembly 32 is then sterilized.
  • each of the outer cap 44, the inner cap 46, the nozzle adapter 70 (except the micro nozzle 50) and the lock ring 42 is made of an ETO transparent material.
  • the neck 37 of the cartridge 35 and the micro nozzle 50 can be reached by ETO gas during the sterilization.
  • One or several such assemblies 32 can then be delivered to a user.
  • the user can connect the assembly 32 to a spray device 26.
  • the user can disconnect the assembly 32 from the cartridge holder 30 and attach a new assembly 32 to the same cartridge holder 30.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne un ensemble (32) pour un dispositif de pulvérisation (26), l'ensemble (32) comprenant une buse (50); une cartouche (35) pour contenir un liquide à mettre sous pression et à pousser à travers la buse (50) pour former un aérosol; et un adaptateur de cartouche (38) fixé à la cartouche (35) et agencé pour maintenir la buse (50) en position par rapport à la cartouche (35). L'invention concerne également un dispositif de pulvérisation (26) comprenant un ensemble (32), un dispositif d'administration de médicament comprenant un ensemble (32) ou un dispositif de pulvérisation (26), et un procédé de fourniture d'un ensemble (32) pour un dispositif de pulvérisation (26).
PCT/EP2019/063575 2018-05-29 2019-05-27 Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé Ceased WO2019228946A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862677289P 2018-05-29 2018-05-29
US62/677,289 2018-05-29

Publications (1)

Publication Number Publication Date
WO2019228946A1 true WO2019228946A1 (fr) 2019-12-05

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PCT/EP2019/063575 Ceased WO2019228946A1 (fr) 2018-05-29 2019-05-27 Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4270002A1 (fr) * 2022-04-28 2023-11-01 Büchi Labortechnik AG Support pour une cartouche et procédé de retrait d'une cartouche d'un dispositif de chromatographie

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012063124A1 (fr) * 2010-11-12 2012-05-18 Wolfe Tory Medical, Inc Atomiseur pour thérapie nasale
WO2013125555A1 (fr) * 2012-02-21 2013-08-29 ノズルネットワーク株式会社 Dispositif d'atomisation de liquide
WO2014111370A1 (fr) 2013-01-15 2014-07-24 Carebay Europe Ltd Dispositif d'administration de médicament
WO2014137215A1 (fr) * 2013-03-07 2014-09-12 Medspray Xmems B.V. Générateur d'aérosol destiné à générer un aérosol pour inhalation
WO2015194962A1 (fr) * 2014-06-20 2015-12-23 Medspray B.V. Aérosol ou dispositif de pulvérisation, unité de buse de pulvérisation et procédé de fabrication associé
CN107497036A (zh) * 2017-08-28 2017-12-22 宁波正力药品包装有限公司 一种鼻腔给药装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012063124A1 (fr) * 2010-11-12 2012-05-18 Wolfe Tory Medical, Inc Atomiseur pour thérapie nasale
WO2013125555A1 (fr) * 2012-02-21 2013-08-29 ノズルネットワーク株式会社 Dispositif d'atomisation de liquide
WO2014111370A1 (fr) 2013-01-15 2014-07-24 Carebay Europe Ltd Dispositif d'administration de médicament
WO2014137215A1 (fr) * 2013-03-07 2014-09-12 Medspray Xmems B.V. Générateur d'aérosol destiné à générer un aérosol pour inhalation
WO2015194962A1 (fr) * 2014-06-20 2015-12-23 Medspray B.V. Aérosol ou dispositif de pulvérisation, unité de buse de pulvérisation et procédé de fabrication associé
CN107497036A (zh) * 2017-08-28 2017-12-22 宁波正力药品包装有限公司 一种鼻腔给药装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4270002A1 (fr) * 2022-04-28 2023-11-01 Büchi Labortechnik AG Support pour une cartouche et procédé de retrait d'une cartouche d'un dispositif de chromatographie
WO2023209064A1 (fr) * 2022-04-28 2023-11-02 Büchi Labortechnik AG Support pour cartouche et procédé de fabrication de cartouche de dispositif de chromatographie

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