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WO2019246120A3 - Microarray and method of identifying interactions between compounds and rna - Google Patents

Microarray and method of identifying interactions between compounds and rna Download PDF

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Publication number
WO2019246120A3
WO2019246120A3 PCT/US2019/037762 US2019037762W WO2019246120A3 WO 2019246120 A3 WO2019246120 A3 WO 2019246120A3 US 2019037762 W US2019037762 W US 2019037762W WO 2019246120 A3 WO2019246120 A3 WO 2019246120A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
microarray
provides
compounds
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2019/037762
Other languages
French (fr)
Other versions
WO2019246120A2 (en
Inventor
Matthew D. Disney
Jessica L. Childs-Disney
Sai Pradeep VELAGAPUDI
Tuan Tran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2019246120A2 publication Critical patent/WO2019246120A2/en
Publication of WO2019246120A3 publication Critical patent/WO2019246120A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a microarray having a substrate coated with a gel and a plurality of compounds that are non-covalently adhered to the gel at discrete locations. The invention also provides a method of identifying binding interactions between a compound and an RNA by using a microarray. The invention also provides a method of treating a subject suffering from an RNA mediated disease by administering compounds identified has having a binding interaction with the RNA which mediate the disease. For example, the invention provides a method of preventing or reducing cancer metathesis in a subject by administering to the subject a topoisomerase inhibitor which binds with miR-21.
PCT/US2019/037762 2018-06-19 2019-06-18 Microarray and method of identifying interactions between compounds and rna Ceased WO2019246120A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862686834P 2018-06-19 2018-06-19
US62/686,834 2018-06-19

Publications (2)

Publication Number Publication Date
WO2019246120A2 WO2019246120A2 (en) 2019-12-26
WO2019246120A3 true WO2019246120A3 (en) 2020-04-23

Family

ID=67513725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/037762 Ceased WO2019246120A2 (en) 2018-06-19 2019-06-18 Microarray and method of identifying interactions between compounds and rna

Country Status (1)

Country Link
WO (1) WO2019246120A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116134316A (en) * 2020-08-12 2023-05-16 露点治疗公司 Method for identifying interactions of compounds with condensates or components thereof and uses thereof
CN112480083A (en) * 2020-11-06 2021-03-12 上海应用技术大学 AZD9291 derivative containing alkynyl and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050079506A1 (en) * 2003-10-09 2005-04-14 Eastman Kodak Company Filled, biological microarray and method for use
US20080188377A1 (en) * 2006-11-29 2008-08-07 Disney Matthew D Methods for identifying ligands that target nucleic acid molecules and nucleic acid structural motifs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9586944B2 (en) 2013-07-15 2017-03-07 The Scripps Research Institute Specific targeting of RNA expanded repeat sequences
ES2733030T3 (en) 2013-08-09 2019-11-27 Scripps Research Inst Complete transcriptome design of small, bioactive, selective molecules that select as RNA target

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050079506A1 (en) * 2003-10-09 2005-04-14 Eastman Kodak Company Filled, biological microarray and method for use
US20080188377A1 (en) * 2006-11-29 2008-08-07 Disney Matthew D Methods for identifying ligands that target nucleic acid molecules and nucleic acid structural motifs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MA H ET AL: "Chemical microarray: a new tool for drug screening and discovery", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 13-14, 1 July 2006 (2006-07-01), pages 661 - 668, XP027889268, ISSN: 1359-6446, [retrieved on 20060701] *

Also Published As

Publication number Publication date
WO2019246120A2 (en) 2019-12-26

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