[go: up one dir, main page]

WO2019133098A3 - Plate-forme microfluidique pour analyse à résolution temporelle de tissus et d'organismes - Google Patents

Plate-forme microfluidique pour analyse à résolution temporelle de tissus et d'organismes Download PDF

Info

Publication number
WO2019133098A3
WO2019133098A3 PCT/US2018/056790 US2018056790W WO2019133098A3 WO 2019133098 A3 WO2019133098 A3 WO 2019133098A3 US 2018056790 W US2018056790 W US 2018056790W WO 2019133098 A3 WO2019133098 A3 WO 2019133098A3
Authority
WO
WIPO (PCT)
Prior art keywords
time
microfluidic platform
organism analysis
resolved tissue
microfluidic system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2018/056790
Other languages
English (en)
Other versions
WO2019133098A2 (fr
Inventor
Richard Novak
Youngjae CHOE
Bret NESTOR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of WO2019133098A2 publication Critical patent/WO2019133098A2/fr
Publication of WO2019133098A3 publication Critical patent/WO2019133098A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un système microfluidique comprenant une plate-forme automatisée pour la culture d'embryons incluant une imagerie hyperspectrale. Le système microfluidique comprend par ailleurs une pluralité de puces statiques disposées sur la plate-forme automatisée et destinées à assurer un échange de substances fraîches avec un mouvement embryonnaire minimal. La pluralité de puces statiques sont compatibles avec des outils de référence conventionnels.
PCT/US2018/056790 2017-10-20 2018-10-19 Plate-forme microfluidique pour analyse à résolution temporelle de tissus et d'organismes Ceased WO2019133098A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762575265P 2017-10-20 2017-10-20
US62/575,265 2017-10-20

Publications (2)

Publication Number Publication Date
WO2019133098A2 WO2019133098A2 (fr) 2019-07-04
WO2019133098A3 true WO2019133098A3 (fr) 2019-09-12

Family

ID=67066526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/056790 Ceased WO2019133098A2 (fr) 2017-10-20 2018-10-19 Plate-forme microfluidique pour analyse à résolution temporelle de tissus et d'organismes

Country Status (1)

Country Link
WO (1) WO2019133098A2 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6118890A (en) * 1997-11-12 2000-09-12 International Business Machines Corporation System and method for broad classification of biometric patterns
US20100063741A1 (en) * 2008-09-07 2010-03-11 Edward Lakatos Calculating sample size for clinical trial
US20120044339A1 (en) * 2010-08-19 2012-02-23 Stith Curtis W Opto-fluidic microscope system with evaluation chambers
WO2016063199A1 (fr) * 2014-10-20 2016-04-28 Ecole Polytechnique Federale De Lausanne (Epfl) Dispositif microfluidique, système et procédé permettant l'étude d'organismes
US20160114322A1 (en) * 2013-04-19 2016-04-28 Qichao Pan Parallelized sample handling
WO2017027838A1 (fr) * 2015-08-13 2017-02-16 President And Fellows Of Harvard College Dispositifs et systèmes microfluidiques pour culture cellulaire et/ou essai cellulaire

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6118890A (en) * 1997-11-12 2000-09-12 International Business Machines Corporation System and method for broad classification of biometric patterns
US20100063741A1 (en) * 2008-09-07 2010-03-11 Edward Lakatos Calculating sample size for clinical trial
US20120044339A1 (en) * 2010-08-19 2012-02-23 Stith Curtis W Opto-fluidic microscope system with evaluation chambers
US20160114322A1 (en) * 2013-04-19 2016-04-28 Qichao Pan Parallelized sample handling
WO2016063199A1 (fr) * 2014-10-20 2016-04-28 Ecole Polytechnique Federale De Lausanne (Epfl) Dispositif microfluidique, système et procédé permettant l'étude d'organismes
WO2017027838A1 (fr) * 2015-08-13 2017-02-16 President And Fellows Of Harvard College Dispositifs et systèmes microfluidiques pour culture cellulaire et/ou essai cellulaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG KEVIN, ET AL.: "Toward Embedded Laboratory Automation for Smart Lab-on-a-Chip Embryo Arrays", BIOSENSORS AND BIOELECTRONICS, vol. 48, 30 April 2013 (2013-04-30), pages 188 - 196, XP055637682 *

Also Published As

Publication number Publication date
WO2019133098A2 (fr) 2019-07-04

Similar Documents

Publication Publication Date Title
CL2021001024A1 (es) Calibración automática y mantenimiento automático de modelos espectroscópicos de raman para predicciones en tiempo real
WO2020123316A3 (fr) Procédés de détermination d'un emplacement d'un analyte biologique dans un échantillon biologique
WO2019204632A8 (fr) Procédé et système d'analyse génétique rapide
DK2173853T3 (da) Indretning, system og fremgangsmåde til at overvåge og/eller dyrke mikroskopiske objekter
CO2019002607A2 (es) Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activación por contacto
BR112016028512A8 (pt) método de cultivo de uma célula de mamífero e método de produção de uma proteína recombinante
FR3044679B1 (fr) Procede de culture d'algues, particulierement d'algues rouges unicellulaires (arus), avec du lactose
WO2015164747A8 (fr) Procédés de diagnostic de la maladie coeliaque à l'aide de cytokines/chimiokines circulantes
BR112019006862A2 (pt) dispositivo de análise e método para testagem de uma amostra
WO2016003516A3 (fr) Localisation radiofréquence
WO2019133098A3 (fr) Plate-forme microfluidique pour analyse à résolution temporelle de tissus et d'organismes
BRPI0606728A2 (pt) dispositivo para a determinação da uniformidade de uma batelada de sementes
AR114264A1 (es) Detección de endófitos
JP1643696S (ja) 恒温培養器
EA202090585A1 (ru) Птицы с отредактированным геномом
EP4282946A4 (fr) Dispositif de culture d'embryons et dispositif d'imagerie associé
MX2019002932A (es) Biomarcadores proteicos para enfermedades asociadas con el sistema de activacion por contacto.
CA3057018C (fr) Cachette amovible pour habitat pour petit animal
AR093242A1 (es) Metodo para facilitar la planificacion de un menu
BR112017007213A2 (pt) "processamento e utilização de fluidos do trato reprodutivo para melhorar a produção in vitro de embriões de mamífero"
RU2015109280A (ru) Способ дифференцировки живых сперматозоидов с помощью диагностической культуральной среды при абсолютной астенозооспермии в рамках экстракорпорального оплодотворения
WO2018089683A3 (fr) Système et procédé de consultation de lectures de plaques de culture
UA118520U (uk) Оптимізоване поживне середовище для культивування клітин-продуцентів антигену вірусу лейкозу великої рогатої худоби
UA80922U (ru) Способ оценки токсичности препаратов по влиянию на сперматозоиды хряка вне организма
MX380982B (es) Biodisponibilidad de iones de metal.

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18895741

Country of ref document: EP

Kind code of ref document: A2