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WO2019131308A1 - TRAITEMENT D'UNE ARYTHMIE EN FAISANT APPEL À LA 9-β-D-ARABINOFURANOSYLHYPOXANTINE - Google Patents

TRAITEMENT D'UNE ARYTHMIE EN FAISANT APPEL À LA 9-β-D-ARABINOFURANOSYLHYPOXANTINE Download PDF

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Publication number
WO2019131308A1
WO2019131308A1 PCT/JP2018/046477 JP2018046477W WO2019131308A1 WO 2019131308 A1 WO2019131308 A1 WO 2019131308A1 JP 2018046477 W JP2018046477 W JP 2018046477W WO 2019131308 A1 WO2019131308 A1 WO 2019131308A1
Authority
WO
WIPO (PCT)
Prior art keywords
ara
atrial fibrillation
arrhythmia
treatment
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/046477
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English (en)
Japanese (ja)
Inventor
藤田　孝之
石川　義弘
中村　隆
敏 奥村
憲治 吹田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yokohama City University
Original Assignee
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yokohama City University filed Critical Yokohama City University
Priority to JP2019561537A priority Critical patent/JP7137852B2/ja
Publication of WO2019131308A1 publication Critical patent/WO2019131308A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Definitions

  • the present invention provides an antiarrhythmic drug comprising 9- ⁇ -D-arabinofuranosyl hypoxanthine, a pharmaceutically acceptable salt or solvate thereof.
  • the present invention relates to the treatment and / or treatment of arrhythmia comprising administering to a subject a pharmaceutically effective amount of 9- ⁇ -D-arabinofuranosyl hypoxanthine, a pharmaceutically acceptable salt or solvate thereof. Or provide a preventive method.
  • the present invention provides 9- ⁇ -D-arabinofuranosyl hypoxanthine, a pharmaceutically acceptable salt or solvate thereof, for the treatment and / or prevention of arrhythmia.
  • Carriers such as distilled water and physiological saline should be used when formulated into injections, and starches, lactose, sucrose, calcium carbonate etc. when formulated into capsules, tablets, powders, and granules.
  • the content of active ingredient in the formulation can be varied between 1 and 99% by weight.
  • Atrial fibrillation attack was induced by this method, and Ara-Hx (5, 10, 20 mg / kg) or DMSO only (CTRL) was intravenously administered during the stroke one minute after the onset of atrial fibrillation.
  • Ara-Hx suppresses the generation of reactive oxygen species in cardiomyocytes (FIG. 6) Reactive oxygen species in cardiomyocytes are known to be an important mechanism for the onset of atrial fibrillation and ventricular arrhythmias (JY Youn et al. J Mol Cell Cardiol 62 (2013) 72-79, AD Hafstad et al. Basic Res Cardiol 108 (2013) 359.).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un nouvel agent thérapeutique pour traiter une arythmie. L'invention concerne un agent anti-arythmique comprenant la 9-β-D-arabinofuranosylhypoxanthine, un sel pharmaceutiquement acceptable de celle-ci ou un solvate de celle-ci.
PCT/JP2018/046477 2017-12-27 2018-12-18 TRAITEMENT D'UNE ARYTHMIE EN FAISANT APPEL À LA 9-β-D-ARABINOFURANOSYLHYPOXANTINE Ceased WO2019131308A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019561537A JP7137852B2 (ja) 2017-12-27 2018-12-18 ９‐β‐Ｄ‐アラビノフラノシルヒポキサンチンによる不整脈治療

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017250478 2017-12-27
JP2017-250478 2017-12-27

Publications (1)

Publication Number Publication Date
WO2019131308A1 true WO2019131308A1 (fr) 2019-07-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/046477 Ceased WO2019131308A1 (fr) 2017-12-27 2018-12-18 TRAITEMENT D'UNE ARYTHMIE EN FAISANT APPEL À LA 9-β-D-ARABINOFURANOSYLHYPOXANTINE

Country Status (2)

Country Link
JP (1) JP7137852B2 (fr)
WO (1) WO2019131308A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023033166A1 (fr) 2021-09-06 2023-03-09 ミライラボバイオサイエンス株式会社 Agent de traitement de cardiopathie et procédé d'atténuation d'une cardiopathie

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013051330A1 (fr) * 2011-10-07 2013-04-11 公立大学法人横浜市立大学 Traitement de la fibrillation auriculaire à l'aide de vidarabine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106420790A (zh) * 2016-09-13 2017-02-22 北京大学 次黄嘌呤核苷酸在制备心肌力增强制剂中的用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013051330A1 (fr) * 2011-10-07 2013-04-11 公立大学法人横浜市立大学 Traitement de la fibrillation auriculaire à l'aide de vidarabine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAMPNEY, K. J. ET AL.: "Antiherpesvirus activity in human sera and urines after administration of adenine arabinoside", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 62, no. 6, 1 December 1978 (1978-12-01), pages 1142 - 1153, XP055623414, ISSN: 0021-9738 *
CHEN, P. S. ET AL.: "Role of the autonomic nervous system in atrial fibrillation: Pathophysiology and Therapy", CIRCULATION RESEARCH, vol. 114, no. 9, 25 April 2014 (2014-04-25), pages 1500 - 1515, XP055300161, ISSN: 0009-7330, doi:10.1161/CIRCRESAHA.114.303772 *
DE MICHELI, A ET AL.: "Antiarrhythmic and arrhythmogenic action of inosine in experimental ventricular tachyarrhythmias", ARCHIVOS DE CARDIOLOGIA DE MEXICO, vol. 79, no. 3, July 2009 (2009-07-01), pages 175 - 181, XP055623422, ISSN: 1405-9940 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023033166A1 (fr) 2021-09-06 2023-03-09 ミライラボバイオサイエンス株式会社 Agent de traitement de cardiopathie et procédé d'atténuation d'une cardiopathie
KR20240051234A (ko) 2021-09-06 2024-04-19 미라이랩 바이오사이언스 인코퍼레이티드 심장질환용제 및 심장질환의 개선 방법

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JPWO2019131308A1 (ja) 2020-12-10
JP7137852B2 (ja) 2022-09-15

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