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WO2019130252A3 - Procédés et intermédiaires destinés à la préparation de la deutétrabenazine - Google Patents

Procédés et intermédiaires destinés à la préparation de la deutétrabenazine Download PDF

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Publication number
WO2019130252A3
WO2019130252A3 PCT/IB2018/060678 IB2018060678W WO2019130252A3 WO 2019130252 A3 WO2019130252 A3 WO 2019130252A3 IB 2018060678 W IB2018060678 W IB 2018060678W WO 2019130252 A3 WO2019130252 A3 WO 2019130252A3
Authority
WO
WIPO (PCT)
Prior art keywords
deutetrabenazine
intermediates
preparing
methods
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/060678
Other languages
English (en)
Other versions
WO2019130252A2 (fr
Inventor
Sureshbabu JAYACHANDRA
Veera Venkata Srinivasarao ATTANTI
Rathinapandian JABARAJ
Shivakumar CHANDUPATLA
Srinivas KOMMARAJU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Mylan Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Publication of WO2019130252A2 publication Critical patent/WO2019130252A2/fr
Publication of WO2019130252A3 publication Critical patent/WO2019130252A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation de deutétrabenazine et d'intermédiaires utiles dans la préparation de cette dernière. L'invention concerne également un procédé de fabrication de la deuxabénazine amorphe.
PCT/IB2018/060678 2017-12-29 2018-12-28 Procédés et intermédiaires destinés à la préparation de la deutétrabenazine Ceased WO2019130252A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201741047280 2017-12-29
IN201741047280 2017-12-29
IN201841006981 2018-02-23
IN201841006981 2018-02-23

Publications (2)

Publication Number Publication Date
WO2019130252A2 WO2019130252A2 (fr) 2019-07-04
WO2019130252A3 true WO2019130252A3 (fr) 2019-08-08

Family

ID=65409119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/060678 Ceased WO2019130252A2 (fr) 2017-12-29 2018-12-28 Procédés et intermédiaires destinés à la préparation de la deutétrabenazine

Country Status (1)

Country Link
WO (1) WO2019130252A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3784238A4 (fr) * 2018-04-27 2021-12-29 Hetero Labs Ltd. Procédé de préparation de ((3r, 11br) -1,3,4,6,7,11b-hexahydro-9,10-di(méthoxy-d 3)-3-(2-méthylpropyl)-2h-benzo[a]quinolizin-2-one
EP4479051A1 (fr) * 2022-02-15 2024-12-25 Foresee Pharmaceuticals Co., Ltd. (+)-tétrabénazine cristalline
CN116212963B (zh) * 2023-02-27 2024-01-09 安徽泽升科技股份有限公司 一种氘代碘甲烷的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (fr) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Inhibiteurs benzoquinoline du transporteur de monoamines vésiculaire 2
US20150152099A1 (en) * 2013-12-03 2015-06-04 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (fr) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Inhibiteurs benzoquinoline du transporteur de monoamines vésiculaire 2
US20150152099A1 (en) * 2013-12-03 2015-06-04 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds

Also Published As

Publication number Publication date
WO2019130252A2 (fr) 2019-07-04

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