WO2019127130A1 - Method, apparatus, chip and detection device for substance detection - Google Patents

Abstract

A method, apparatus, chip and detection device for substance detection, relating to the field of substance component detection. The method comprises: (S302) determining partitions to be detected in a chip; (S304) aligning a laser source in a detection device with said partitions; and (S306) detecting substances in said partitions in sequence by means of the detection device. According to the method, apparatus, chip and detection device for substance detection, the detection efficiency of Raman detection can be improved and detection costs can be reduced.

Description

Method, device, chip and detection device for substance detection Technical field

The present invention relates to the field of computer information processing, and in particular to a method, device, chip and detection device for substance detection.

Background technique

Raman spectroscopy is based on the Raman scattering effect discovered by Indian scientist CV Raman. The scattering spectrum is different from the incident light frequency to obtain molecular vibration and rotation information, and is applied to molecular structure research. An analytical method. The Raman spectroscopy analysis method does not require pre-treatment of the sample, nor the preparation process of the sample, avoids some errors, and has the advantages of simple operation, short measurement time and high sensitivity in the analysis process.

The surface-enhanced Raman scattering (SERS) effect refers to the Raman scattering signal of the adsorbed molecules in the excitation region due to the enhancement of the electromagnetic field on the surface of the sample or near the surface in the specially prepared metal conductor surface or sol. The Mann Scattering (NRS) signal is greatly enhanced. Surface-enhanced Raman overcomes the shortcomings of Raman spectroscopy with low sensitivity, and can obtain structural information that is not easily obtained by conventional Raman spectroscopy. It is widely used in surface research, adsorption interface surface state research, interface orientation and configuration of biological size molecules, Conformation research, structural analysis, etc., can effectively analyze the adsorption orientation of the compound at the interface, the change of the adsorption state, and the interface information.

At present, Raman detection on the market is more and more widely used, and Raman enhancement chips for detection of low-concentration substances, such as pesticide residues, cell detection, etc., have also begun to be applied in a small range. Surface-enhanced Raman scattering (SERS) technology overcomes the shortcomings of the traditional Raman spectroscopy's inherent weak signal, which can increase the Raman signal strength by several orders of magnitude, so that low-concentration substances are also sufficient to be detected. However, the Raman enhancement chip is composed of a nanomaterial attached to a silicon wafer or a quartz wafer, and is currently expensive. Moreover, for Raman detection, if continuous multi-sample detection is required, the new Raman enhancement chip is frequently replaced, resulting in low Raman detection efficiency. The high cost of Raman chips and the low detection efficiency of Raman detection equipment are technical problems that need to be solved urgently.

Therefore, there is a need for a new method, device, chip and detection device for substance detection.

The above information disclosed in the Background section is only for enhancement of understanding of the background of the invention, and thus it may include information that does not constitute the prior art known to those of ordinary skill in the art.

Summary of the invention

In view of this, the present invention provides a method, device, chip and detection device for substance detection, which can improve the detection efficiency of Raman detection and save the detection cost.

Other features and advantages of the present invention will be apparent from the description and appended claims.

According to a first aspect of the present invention, a method for substance detection is provided, the method comprising: determining a partition to be detected in a chip; aligning a laser source in the detecting device with the to-be-detected partition; and The to-be-detected partition sequentially performs substance detection.

According to a second aspect of the present invention, an apparatus for substance detection is provided, the apparatus comprising: a partitioning module configured to determine a partition to be detected in a chip; and an adjustment module configured to align a laser source in the detecting apparatus Determining the detection partition; and the detecting module is configured to sequentially perform substance detection on the to-be-detected partition by the detecting device.

According to a third aspect of the present invention, a chip for substance detection is provided, the chip comprising: a lower substrate, a middle substrate and an upper substrate; the upper substrate is for carrying a substance to be detected, the upper layer The slice is divided into a plurality of partitions by a raised dividing line.

According to a fourth aspect of the present invention, a detecting apparatus for substance detection is provided, the detecting apparatus comprising: a chip placement platform; a laser source; the laser source and the chip placement platform are capable of relative movement, by relative movement The laser source detects any partition on the chip.

According to a fifth aspect of the invention there is provided an electronic device comprising: one or more processors; a storage device arranged to store one or more programs; when one or more programs are processed by one or more The processor is executed such that one or more processors implement the method as described above.

According to a sixth aspect of the invention, there is provided a computer readable medium having stored thereon a computer program which, when executed by a processor, implements a method as hereinbefore described.

According to the method, device, chip and detection apparatus for substance detection according to the present invention, the detection efficiency of Raman detection can be improved, and the detection cost can be saved.

The above general description and the following detailed description are merely exemplary and are not intended to limit the invention.

DRAWINGS

Figure 1 is an illustration of a prior art Raman enhancement chip.

2 is a schematic diagram of a partition of a chip for substance detection, according to an exemplary embodiment.

FIG. 3 is a flow chart showing a method for substance detection, according to an exemplary embodiment.

4 is a schematic diagram of a center position of a chip in a method for substance detection, according to an exemplary embodiment.

FIG. 5 is a schematic diagram of a laser head angle in a method for substance detection, according to an exemplary embodiment.

FIG. 6 is a flow chart showing a method for substance detection, according to another exemplary embodiment.

FIG. 7 is a schematic diagram showing the measurement results of a chip in a method for substance detection according to an exemplary embodiment.

FIG. 8 is a block diagram of an apparatus for substance detection, according to an exemplary embodiment.

FIG. 9 is a block diagram of an electronic device, according to an exemplary embodiment.

FIG. 10 schematically shows a schematic diagram of a computer readable storage medium in an exemplary embodiment of the present disclosure.

Detailed ways

Example embodiments will now be described more fully with reference to the accompanying drawings. However, the exemplary embodiments can be embodied in a variety of forms and should not be construed as being limited to the embodiments set forth herein. To those skilled in the art. The same reference numerals in the drawings denote the same or similar parts, and the repeated description thereof will be omitted.

Furthermore, the described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments. In the following description, numerous specific details are set forth However, one skilled in the art will appreciate that the technical solution of the present invention may be practiced without one or more of the specific details, or other methods, components, devices, steps, etc. may be employed. In other instances, well-known methods, devices, implementations, or operations are not shown or described in detail to avoid obscuring aspects of the invention.

The block diagrams shown in the figures are merely functional entities and do not necessarily have to correspond to physically separate entities. That is, these functional entities may be implemented in software, or implemented in one or more hardware modules or integrated circuits, or implemented in different networks and/or processor devices and/or microcontroller devices. entity.

The flowcharts shown in the figures are merely illustrative, and not all of the contents and operations/steps are necessarily included, and are not necessarily performed in the order described. For example, some operations/steps may be decomposed, and some operations/steps may be combined or partially merged, so the actual execution order may vary depending on the actual situation.

It will be understood by those skilled in the art that the drawings are only schematic diagrams of exemplary embodiments, and the modules or processes in the drawings are not necessarily required to implement the invention, and therefore are not intended to limit the scope of the invention.

Figure 1 is an illustration of a prior art Raman enhanced chip. In the prior art, there is no partition on the Raman enhancement chip, and one Raman enhanced detection chip can only perform one substance detection. FIG. 2 is a schematic diagram showing the partitioning of a chip for substance detection according to an exemplary embodiment.

Wherein, the chip for substance detection may be a Raman enhancement chip, the chip comprises: a lower substrate, a middle substrate and an upper substrate; the upper substrate is used to carry a substance to be detected, and the upper substrate passes through the convex The dividing line is divided into multiple partitions.

In one embodiment, the chip for substance detection of the present application may take any form of partitioning, preferably, in an aliquoting manner.

In one embodiment, the internal Raman enhanced partition partitioning may be different when the off-chip dimensions are identical. The division of the division interval may, for example, adopt a convex separation line to prevent the liquid in a certain partition from being excessive to the other partitions, resulting in an error in the detection result.

According to an aspect of the present invention, a detecting apparatus for substance detection is provided, the detecting apparatus comprising: a chip placement platform; a laser source; the laser source and the chip placement platform are capable of relative movement, by relative movement The laser source detects any partition on the chip. For example, the Raman enhancement chip is inserted into the interior of the detection device, and the laser focal length of the detection device after insertion is in the plane in which the Raman enhancement chip is located. By the translational motion of the mechanical structure or the change in the angle of the laser beam, the laser focus position can be sequentially placed on each of the partitions.

In one embodiment, a manner in which the laser source moves relative to the chip placement platform includes: a fixed position of the laser source, a manner in which the chip is translated, or a fixed position of the chip, and a manner in which the laser source translates Or the fixed position of the chip, the manner in which the beam of the laser source changes angle.

FIG. 3 is a flow chart showing a method for substance detection, according to an exemplary embodiment.

As shown in FIG. 3, in S302, the partition to be detected in the chip is determined. Among them, the chip includes: Raman enhanced chip. As in the example of FIG. 2, the Raman enhancement chip in the present application may include, for example, a plurality of partitions. In an embodiment, before determining the to-be-detected partition in the chip, the method further includes: receiving at least one substance to be detected through the chip, and the Raman enhancement chip may adopt any form of partitioning to divide the area of the one enhanced chip into Multiple partitions, respectively, smeared or dropped a variety of substances to be tested (a substance to be tested in one partition). The method further includes: acquiring distribution information of the partitions in the chip according to the identifier of the chip.

In S304, the laser source in the detecting device is aligned with the to-be-detected partition. Detection equipment, including: Raman detection equipment. Aligning the laser source in the detecting device with the to-be-detected partition includes: fixing the position by the laser source, the chip shifting manner, so that the laser source is aligned with the to-be-detected partition; or passing the chip a fixed position, the laser source is translated in such a manner that the laser source is aligned with the to-be-detected partition; or by the chip fixed position, the beam of the laser source varies in angle so that the laser source is aligned to the to-be-detected Partition.

In S306, substance detection is sequentially performed on the to-be-detected partition by the detecting device. For example, the coordinate point set is generated by the center coordinates of the partition to be detected, and when there are a plurality of partitions to be detected, the substance detection is sequentially performed from any coordinate point in the coordinate point set. The order of the substance detection can also be optimized by the user, for example, or according to the position of the chip partition and the path to be moved by the laser head, and then the substance detection is performed sequentially according to the optimized path, which is not limited by the invention. In one embodiment, performing substance detection on the to-be-detected partition in the chip by using the detection device according to the distribution information of the partition, including: sequentially determining a center coordinate of the to-be-detected partition according to the distribution information of the partition. And the laser source in the detecting device is sequentially aligned with the central coordinate of the partition to be detected, and the substance to be detected is sequentially detected. The distribution information of the partition includes: a layout manner of each partition in the chip, and a center point coordinate of each partition in the chip.

According to the method for detecting a substance of the present invention, a Raman-enhanced chip having a plurality of partitions carries a plurality of substances, and further, by adjusting a laser head of the detecting device, the laser heads are sequentially aligned with each of the partitions on the chip, thereby The manner in which the substances in the partition are sequentially detected can improve the detection efficiency of the Raman detection and save the detection cost.

In an exemplary embodiment of the present disclosure, acquiring, according to the identifier of the chip, the distribution information of the partition in the chip, including: acquiring, according to the identifier of the chip, a storage area in the chip Obtaining the distribution information of the partition in the chip by using the storage area in the detecting device according to the identifier of the chip; or acquiring the partition in the chip according to the identifier of the chip Distribution information. For the same device, the peripheral size of the Raman enhancement chip is generally fixed, as long as the specification of the chip can be recognized when the Raman enhancement chip is inserted. For example, by reading the ID number of the Raman enhancement chip, the chip is obtained as 9 partitions, and the center point coordinate position of each partition. For example, the number of partitions and the coordinate position of the center point of each partition can be read by the embedded information of the chip, or only the ID number can be read, and the corresponding ID number corresponding to the ID number is corresponding to the terminal or the cloud according to the ID number. The number of partitions of the MAN enhancement chip and the coordinates of the center point of each partition. Since the total number of partitions can also have different segmentation methods, in the present application, the Raman enhancement chips with different specifications are given different ID numbers, so that the detection device can correctly distinguish the partitions on the chip.

In an exemplary embodiment of the present disclosure, the determining a to-be-detected partition in the chip includes: determining a to-be-detected partition in the chip according to a user instruction; or identifying the chip according to the detecting device As a result, the partition to be detected in the chip is determined. The determining the to-be-detected partition in the chip according to the user instruction includes: generating partition display information by using the distribution information of the partition; displaying the partition display information on the display end; and displaying information by the user according to the partition Prompt to determine the partition to be detected.

4 is a schematic diagram of a center position of a chip in a method for substance detection, according to an exemplary embodiment. FIG. 5 is a schematic diagram of a laser head angle in a method for substance detection, according to an exemplary embodiment. The three ways of aligning the laser source in the detecting device with the to-be-detected partition are exemplarily described with reference to FIGS. 4 and 5.

Manner 1: The laser source is fixed in position, and the chip is translated in such a manner that the laser source is aligned with the to-be-detected partition. For example, the laser path is fixed and the laser focus is fixed. The Raman enhancement chip fixing device can perform the in-plane translation through the mechanical structure, so that the laser focus is irradiated to each partition of the Raman enhancement chip, as shown in FIG. Taking a 9-zone Raman enhancement chip as an example, it is assumed that after the enhancement chip is loaded, the laser focus is opposite to the positive center of the enhancement chip. The positive center is taken as the coordinate origin, the horizontal direction is the X axis, and the vertical direction is the Y axis.

Assuming that the center coordinate point of the first upper left partition is (-2.5, 2) in the 9-partition Raman enhancement chip illustrated in FIG. 4, it can be seen that the mechanical structure carrying the Raman enhancement chip only needs to move to the X-axis positive axis by 2.5. Move 2 to the negative axis of the Y-axis to make the laser focus just hit the center of the partition 1, that is, the movement coordinate of the mechanical structure is (2.5, -2). Other partitions and other specifications of the Raman enhancement chip are the same. Therefore, as long as the mechanical structure is moved, each partition is sequentially placed in the laser focus, and the detection of each of the partitioned substances can be completed in sequence.

Manner 2: The laser source is translated by the fixed position of the chip, so that the laser source is aligned with the to-be-detected partition. For example, the laser head is moved by a mechanical structure in a plane parallel to the Raman-enhanced chip, and the Raman-enhanced chip is immobilized so that the laser focus is sequentially illuminated to each of the sections of the Raman-enhanced chip. This method is the same as the implementation of the first mode, except that the laser head is translated along the X-axis Y-axis. Assume that in the 9-zone Raman enhancement chip of the example of FIG. 4, the center coordinate point of the first upper left partition is (-2.5, 2 It can be seen that the mechanical structure carrying the laser head only needs to move 2.5 to the negative axis of the X-axis and 2 to the positive axis of the Y-axis, so that the laser focus can be irradiated to the center position of the partition 1, that is, the movement coordinate of the mechanical structure. For (-2.5, 2). Other partitions and other specifications of the Raman enhancement chip are the same.

Manner 3: The position of the beam of the laser source varies by the fixed position of the chip, so that the laser source is aligned with the area to be detected. For example, the Raman enhancement chip does not move, and the laser head/laser beam can be rotated at an angle such that the laser focus is sequentially illuminated in each of the sections of the Raman enhancement chip. This approach can enable the laser beam to be focused or approximately focused on each of the sections of the Raman enhancement chip, for example by optical or mechanical construction. Suppose that the coordinates of a certain center point on a Raman-enhanced chip of a multi-partition are (x, y), the X-axis rotation angle of the laser beam is α, the Y-axis rotation angle is β, and the vertical distance of the laser lens to the Raman enhancement chip. For d, the schematic is shown in Figure 5 below.

According to the geometric relationship:

Tanα=x/d;

Tanβ=y/d;

Then it can be solved:

α=arctan(x/d);

==arctan(y/d);

When the coordinates (x, y) of the center point of a certain partition are obtained, the laser beam can be rotated to the partition by rotating the arctan (x/d) along the X axis and the arctan (y/d) by the Y axis. Center point. Alternatively, the laser lens also, for example, automatically adjusts the focus to allow the laser focus to be more precisely focused to each of the zones.

FIG. 6 is a flow chart showing a method for substance detection, according to another exemplary embodiment. FIG. 6 is an exemplary illustration of a method for substance detection, and FIG. 6 details different chip ID acquisition methods and result presentation processes.

Wherein, in S602, the user applies or drops one or more substances to be detected in one or more partitions of the Raman enhancement chip, and maintains only one sample in each partition.

In S604, the Raman enhancement chip is inserted, and the device is turned on to prepare for detection.

In S606, the detecting device detects the inserted Raman enhancement chip, if the coordinate information is completely read from the chip, then the process goes to step 608; if the local or cloud corresponding mode is adopted, then the process goes to step 610.

In S608, the detecting device reads the ID number, the partitioning mode, and the center point coordinate information of each partition from the enhanced chip.

In S610, the detecting device reads the ID number from the enhanced chip, and searches for the enhanced chip type corresponding to the ID number in the local and/or the cloud according to the ID number, and mainly includes the partition mode and the coordinate information of the center point of each partition. A schematic diagram of the partition of the Raman enhancement chip can also be included.

In S612, the detecting device displays the partitioning schematic diagram of the enhanced chip on the screen, and the schematic diagram should be consistent with the partitioning of the enhanced chip.

In S614, the user may tick one or more partitions that need to be detected this time. A 9-partition enhancement chip, you may only use any part of it, such as 5 partitions, and then click to start detection.

In S616, the partition selected by the user is obtained, and may correspond to the coordinate point of the selected partition. Starting from any coordinate point in the set of coordinate points, the detection command and coordinate point information are sent to the detecting device.

In S618, according to one of the above three implementation manners corresponding to the detecting device, the laser focus is positioned at the coordinate point by the translational movement of the mechanical structure or the change of the laser beam angle, and the Raman spectrum is collected, when the collection ends. After (signal to noise ratio compliance), record and match in the database.

In S620, if there is another coordinate point to be detected in the coordinate point set, the detection instruction and the coordinate point information are sent to the detecting device, and the process goes to step 618.

In S622, the detection result is fed back to the user, and the flow is ended. On the screen, for example, a result presentation interface as shown in FIG. 7 can be presented.

According to the method for substance detection of the present invention, a specific enhancement chip can support partitioning of a plurality of patterns and a plurality of patterns by a structure of a specific Raman enhancement chip and a detection device of a specific Raman enhancement chip. In terms of the detection device, the Raman enhancement chip can be inserted into the inside of the inspection device machine, and the laser focal length should be exactly in the plane where the Raman enhancement chip is located after insertion. By reading the enhanced chip ID number to match its partition mode and each partition coordinate point information, and then by detecting the translational motion of the mechanical structure of the device or the change of the laser beam angle, the laser focus position can be automatically selected in the user's selected one or On multiple partitions, the material detection for each partition is completed in turn. According to the method for substance detection of the present invention, the use cost of the Raman-enhanced chip can be reduced, and the detection efficiency of the continuous multi-substance detection can be improved, so that the user experience can be greatly improved.

The following is an embodiment of the apparatus of the present invention, which can be used to carry out the method embodiments of the present invention. For details not disclosed in the embodiment of the device of the present invention, please refer to the method embodiment of the present invention.

FIG. 8 is a block diagram of an apparatus for substance detection, according to an exemplary embodiment. The apparatus 80 for substance detection may include, for example, a partitioning module 802, an adjustment module 804, and a detection module 806.

The partitioning module 802 is configured to determine a partition to be detected in the chip. The chip, wherein the chip comprises: a Raman enhancement chip. As described above, the Raman enhancement chip in the present application may include, for example, a plurality of partitions. In an embodiment, before determining the to-be-detected partition in the chip, the method further includes: receiving at least one substance to be detected through the chip, and the Raman enhancement chip may adopt any form of partitioning to divide the area of the one enhanced chip into Multiple partitions, respectively, smeared or dropped a variety of substances to be tested (a substance to be tested in one partition). The method further includes: acquiring distribution information of the partitions in the chip according to the identifier of the chip.

The adjustment module 804 is configured to align the laser source in the detection device with the zone to be detected. Wherein, the detecting device comprises: a Raman detecting device. Aligning the laser source in the detecting device with the to-be-detected partition includes: fixing the position by the laser source, the chip shifting manner, so that the laser source is aligned with the to-be-detected partition; or passing the chip a fixed position, the laser source is translated in such a manner that the laser source is aligned with the to-be-detected partition; or by the chip fixed position, the beam of the laser source varies in angle so that the laser source is aligned to the to-be-detected Partition.

The detecting module 806 is configured to sequentially perform substance detection on the to-be-detected partition by the detecting device. For example, the coordinate point set is generated by the center coordinates of the partition to be detected, and when there are a plurality of partitions to be detected, the substance detection is sequentially performed from any coordinate point in the coordinate point set. The order of the substance detection can also be optimized by the user, for example, or according to the position of the chip partition and the path to be moved by the laser head, and then the substance detection is performed sequentially according to the optimized path, which is not limited by the invention.

The apparatus 80 for detecting a substance may further include, for example, a partition detecting module (not shown) for acquiring distribution information of the partitions in the chip according to the identifier of the chip, which may include: identifying according to the chip Obtaining, by the storage area in the chip, the distribution information of the partitions in the chip; or acquiring, according to the identifier of the chip, the distribution information of the partitions in the chip by using the storage area in the detecting device; or according to the The identifier of the chip acquires the distribution information of the partitions in the chip in the cloud. For the same device, the peripheral size of the Raman enhancement chip is generally fixed, as long as the specification of the chip can be recognized when the Raman enhancement chip is inserted. For example, by reading the ID number of the Raman enhancement chip, the chip is obtained as 9 partitions, and the center point coordinate position of each partition. For example, the number of partitions and the coordinate position of the center point of each partition can be read by the embedded information of the chip, or only the ID number can be read, and the corresponding ID number corresponding to the ID number is corresponding to the terminal or the cloud according to the ID number. The number of partitions of the MAN enhancement chip and the coordinates of the center point of each partition. Since the total number of partitions can also have different segmentation methods, in the present application, the Raman enhancement chips with different specifications are given different ID numbers, so that the detection device can correctly distinguish the partitions on the chip.

The apparatus 80 for substance detection may also include, for example, a determination partitioning module (not shown) for determining a partition to be detected in the chip according to a user instruction; or identifying the chip according to the detecting apparatus As a result, the partition to be detected in the chip is determined. The determining the to-be-detected partition in the chip according to the user instruction includes: generating partition display information by using the distribution information of the partition; displaying the partition display information on the display end; and displaying information by the user according to the partition Prompt to determine the partition to be detected.

According to the apparatus for detecting substances of the present invention, a Raman-enhanced chip having a plurality of partitions carries a plurality of substances, and further, by adjusting a laser head of the detecting device, the laser heads are sequentially aligned with each of the partitions on the chip, thereby The manner in which the substances in the partition are sequentially detected can improve the detection efficiency of the Raman detection and save the detection cost.

FIG. 9 is a block diagram of an electronic device, according to an exemplary embodiment.

An electronic device 200 according to this embodiment of the present invention will be described below with reference to FIG. The electronic device 200 shown in FIG. 9 is merely an example and should not impose any limitation on the function and scope of use of the embodiments of the present invention.

As shown in Figure 9, electronic device 200 is embodied in the form of a general purpose computing device. The components of the electronic device 200 may include, but are not limited to, at least one processing unit 210, at least one storage unit 220, a bus 230 connecting different system components (including the storage unit 220 and the processing unit 210), a display unit 240, and the like.

Wherein, the storage unit stores program code, and the program code may be executed by the processing unit 210, such that the processing unit 210 performs various exemplary embodiments according to the present invention described in the electronic recipe flow processing method section of the present specification. The steps of the embodiment. For example, the processing unit 210 can perform the steps as shown in FIG. 3 or 6.

The storage unit 220 may include a readable medium in the form of a volatile storage unit, such as a random access storage unit (RAM) 2201 and/or a cache storage unit 2202, and may further include a read only storage unit (ROM) 2203.

The storage unit 220 may also include a program/utility 2204 having a set (at least one) of the program modules 2205, including but not limited to: an operating system, one or more applications, other program modules, and programs. Data, each of these examples or some combination may include an implementation of a network environment.

Bus 230 may be representative of one or more of several types of bus structures, including a memory unit bus or memory unit controller, a peripheral bus, a graphics acceleration port, a processing unit, or a local area using any of a variety of bus structures. bus.

The electronic device 200 can also communicate with one or more external devices 300 (eg, a keyboard, pointing device, Bluetooth device, etc.), and can also communicate with one or more devices that enable the user to interact with the electronic device 200, and/or with Any device (eg, router, modem, etc.) that enables the electronic device 200 to communicate with one or more other computing devices. This communication can take place via an input/output (I/O) interface 250. Moreover, electronic device 200 can also communicate with one or more networks (e.g., a local area network (LAN), a wide area network (WAN), and/or a public network, such as the Internet) via network adapter 260. Network adapter 260 can communicate with other modules of electronic device 200 via bus 230. It should be understood that although not shown in the figures, other hardware and/or software modules may be utilized in conjunction with electronic device 200, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives. And data backup storage systems, etc.

Through the description of the above embodiments, those skilled in the art will readily understand that the example embodiments described herein may be implemented by software or by software in combination with necessary hardware. Therefore, the technical solution according to an embodiment of the present disclosure may be embodied in the form of a software product, which may be stored in a non-volatile storage medium (which may be a CD-ROM, a USB flash drive, a mobile hard disk, etc.) or on a network. A number of instructions are included to cause a computing device (which may be a personal computer, server, or network device, etc.) to perform the above-described processing methods in accordance with embodiments of the present disclosure.

FIG. 10 schematically shows a schematic diagram of a computer readable storage medium in an exemplary embodiment of the present disclosure.

Referring to FIG. 10, a program product 400 configured to implement the above method, which may employ a portable compact disk read only memory (CD-ROM) and includes program code, and may be in a terminal device, is illustrated in accordance with an embodiment of the present invention. For example running on a personal computer. However, the program product of the present invention is not limited thereto, and in the present document, the readable storage medium may be any tangible medium containing or storing a program that can be used by or in connection with an instruction execution system, apparatus or device.

The computer readable medium carries one or more programs, and when the one or more programs are executed by the device, the computer readable medium is configured to: determine a partition to be detected in the chip; Aligning the laser source with the to-be-detected partition; and sequentially performing substance detection on the to-be-detected partition by the detecting device.

In addition, the structures, the proportions, the sizes, and the like shown in the drawings of the present specification are only used to cope with the contents disclosed in the specification, and are understood and read by those skilled in the art, and are not intended to limit the conditions that can be implemented by the present disclosure. Therefore, it does not have technical significance. Any modification of the structure, change of the proportional relationship or adjustment of the size should remain in the present disclosure without affecting the technical effects and the objectives that can be achieved by the present disclosure. The scope of the published technical content can be covered. In the meantime, the terms "upper", "first", "second", and "the" are used in the description, and are not intended to limit the scope of the disclosure. The change or adjustment of the relative relationship is also considered to be an area in which the present invention can be implemented without substantial changes in the technical content.

Claims (20)

A method for substance detection, comprising: Determining a partition to be detected in the chip, wherein the chip includes a plurality of partitions; Aligning a laser source in the detection device with the zone to be detected; The substance in the zone to be detected is detected by the detecting device. The method of claim 1 wherein said chip comprises: Raman enhancement chip. The method of claim 1, the detecting device comprising: Raman inspection equipment. The method of claim 1 further comprising: before determining the partition to be detected in the chip: At least one substance to be detected is received by the chip, and the chip includes a plurality of partitions for carrying the substance to be detected. The method of claim 1 further comprising: before determining the partition to be detected in the chip: Obtaining distribution information of the partitions in the chip according to the identifier of the chip. The method of claim 5, the distribution information of the partition, comprising: The arrangement of each partition in the chip, and The coordinates of the center point of each partition in the chip. The method of claim 5, the obtaining the distribution information of the partitions in the chip according to the identifier of the chip, comprising: Obtaining, by the storage area in the chip, the distribution information of the partitions in the chip according to the identifier of the chip; or Obtaining, by the storage area in the detecting device, distribution information of partitions in the chip according to the identifier of the chip; or Obtaining distribution information of the partitions in the chip in the cloud according to the identifier of the chip. The method of claim 1, wherein the determining a partition to be detected in the chip comprises: Determining the to-be-detected partition in the chip according to a user instruction; or Determining the to-be-detected partition in the chip according to the recognition result of the detecting device on the chip. The method of claim 8, the determining the to-be-detected partition in the chip according to a user instruction, comprising: Generating partition display information by using the distribution information of the partition; Displaying the partition display information on the display side; The user determines the to-be-detected partition according to the prompt of the partition display information. The method of claim 1, wherein the aligning the laser source in the detecting device with the to-be-detected partition comprises: Fixing the position by the laser source, the chip is translated in such a manner that the laser source is aligned with the to-be-detected partition; or The laser source is translated by the manner in which the laser source is translated such that the laser source is aligned with the to-be-detected partition; or By means of the fixed position of the chip, the angle of the beam of the laser source is varied such that the laser source is aligned with the zone to be detected. The method of claim 10, wherein the laser source is aligned with the to-be-detected partition by the angle of the beam of the laser source by the fixed position of the chip, and the method further includes: The laser source performs automatic focus adjustment processing. The method of claim 3, wherein the detecting, by the detecting device, the substance detection of the to-be-detected partition comprises: Substance detection is performed on the to-be-detected partition in the chip by the detecting device according to the distribution information of the partition. The method of claim 12, wherein the detecting, by the detecting device, the substance detection of the to-be-detected partition in the chip according to the distribution information of the partition comprises: Determining, according to the distribution information of the partition, the central coordinates of the to-be-detected partition; and The laser source in the detecting device is sequentially aligned with the central coordinate of the partition to be detected, and the substance to be detected is sequentially detected. A device for substance detection, comprising: a partitioning module, configured to determine a partition to be detected in the chip; An adjustment module configured to align a laser source in the detection device with the to-be-detected partition; The detecting module is configured to detect the substance in the to-be-detected partition by the detecting device. A chip for substance detection, characterized in that The upper substrate of the chip is used to carry the substance to be inspected, and the upper substrate is divided into a plurality of partitions by the raised dividing line. The chip of claim 15 The chip is a Raman enhancement chip, and the Raman enhancement chip includes an upper substrate, a middle substrate, and a lower substrate. A detection device for substance detection, comprising: Chip placement platform; Laser source The laser source and the chip placement platform are capable of relative movement, and the laser source detects the partition on the chip according to any one of claims 15 or 16 by relative movement. The detecting device of claim 17, wherein the laser source and the chip placement platform are relatively moved, comprising: The laser source is fixed in position, the manner in which the chip is translated; or The fixed position of the chip, the manner in which the laser source is translated; or The chip is fixed in a position where the beam of the laser source varies in angle. An electronic device comprising: One or more processors; a storage device configured to store one or more programs; The one or more programs are executed by the one or more processors such that the one or more processors implement the method of any of claims 1-13. A computer readable medium having stored thereon a computer program, the program being executed by a processor to implement the method of any of claims 1-13.

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