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WO2019124862A1 - Composition améliorant les rides de la peau et contenant un extrait de schisandra chinensis à titre de substance active - Google Patents

Composition améliorant les rides de la peau et contenant un extrait de schisandra chinensis à titre de substance active Download PDF

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Publication number
WO2019124862A1
WO2019124862A1 PCT/KR2018/015746 KR2018015746W WO2019124862A1 WO 2019124862 A1 WO2019124862 A1 WO 2019124862A1 KR 2018015746 W KR2018015746 W KR 2018015746W WO 2019124862 A1 WO2019124862 A1 WO 2019124862A1
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WO
WIPO (PCT)
Prior art keywords
extract
lotion
skin wrinkles
cosmetic composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/015746
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English (en)
Korean (ko)
Inventor
김동선
이영실
김지연
손은정
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Institute of Oriental Medicine KIOM
Original Assignee
Korea Institute of Oriental Medicine KIOM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Institute of Oriental Medicine KIOM filed Critical Korea Institute of Oriental Medicine KIOM
Publication of WO2019124862A1 publication Critical patent/WO2019124862A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat

Definitions

  • Schisandra (Schisandra chinensis ) extract as an active ingredient.
  • the skin becomes thinner (in the case of endogenous aging) due to intrinsic aging and photoaging due to various contaminants and ultraviolet light externally, and the elasticity is reduced. As the skin is exposed to ultraviolet rays, The keratinocytes and melanocytes are damaged by UVB.
  • Skin aging is divided into chronologic aging, which occurs in areas that are not exposed to sunlight, and actinic aging, which is a combination of chronologic aging and degenerative changes in the exposed parts of sunlight.
  • chronologic aging occurs in areas that are not exposed to sunlight
  • actinic aging which is a combination of chronologic aging and degenerative changes in the exposed parts of sunlight.
  • characteristic clinical signs of skin are fine wrinkles, atrophy of dermis, and decrease of subcutaneous fat layer.
  • coatse wrinkling and furrowing appear and abnormal elasticity material accumulates and the skin thickens and loosens like leather.
  • the phenomenon seen in chronic sunlight-damaged skin is an abnormal increase in the elastic elastosis and proteoglycan of the upper collagen of the dermis and a significant decrease in collagen, the main protein of the dermis.
  • the dermis consists of the majority of type I collagen, some type II collagen, elastin, proteoglycan, and fibronectin.
  • Collagen imparts strength and tension to the skin, which protects the skin from external stimuli or forces, and it accounts for 90% of the dermis.
  • Collagen reduction is closely related to skin aging.
  • Cells that constitute the skin have decreased cell activity due to endogenous aging, photoaging, and imperfect signal transduction, resulting in increased biosynthesis of matrix metalloproteinases (MMPs), enzymes that degrade skin tissues, decreased collagen biosynthesis, And melanin production, which causes skin blackening, is known to increase.
  • MMPs matrix metalloproteinases
  • MMPs that decompose collagen which is a substrate substance constituting the skin
  • substances that can thicken the skin by proliferating skin cells or increasing the matrix substances constituting the skin, inhibiting melanin biosynthesis And the like are found to alleviate skin symptoms such as wrinkles, loss of elasticity, and skin blackening.
  • Schizandra chinensis is a dicotyledonous plant that is a magnolia plant of the Magnoliaceae. It grows mainly in valleys, the stem is brown and has the property of climbing trees. Leaves are alternate phyllotaxis, wide oval, long oval or ovate, with hairs on the back vein and tooth-like sawtooth on the edge. The flower is bloomed in June to July, is unisolated, and has a slightly reddish yellowish white color. After the flowering, the flower bud of the female flower grows to 3 ⁇ 5cm in length and the fruit runs on the water. Fruits are berries and they are almost round and have several spines.
  • Korean Patent Laid-Open Publication No. 2013-0087938 discloses a cosmetic composition for improving wrinkles containing an extract of Omija
  • Korean Patent Laid-Open Publication No. 2017-0076134 discloses a cosmetic composition containing gum arabicum extract as an active ingredient
  • a wrinkle preventing and anti-inflammatory composition has been disclosed, but a composition for preventing or improving wrinkles of skin containing the extract of the present invention as an active ingredient has not been disclosed.
  • the present invention provides a composition for preventing or ameliorating skin wrinkles comprising an extract of Omija as an active ingredient, and a composition for preventing or treating wrinkles of the omija according to the present invention, Analysis of the collagenase inhibitory activity of the extract showed that the collagenase inhibitory activity of the Omija leaf or stem extract was superior to that of the Omiza fruit extract and that the Omiza leaf extract had a higher expression level of Pro-MMP-1 than the Omiza fruit extract The present invention has been completed.
  • the present invention provides a cosmetic composition for improving skin wrinkles comprising an extract of Omija as an active ingredient.
  • the present invention also provides a health functional food composition for preventing or improving skin wrinkles containing an extract of Omija as an active ingredient.
  • the present invention also provides a quasi-drug composition for preventing or improving skin wrinkles containing an extract of Omija as an active ingredient.
  • the present invention relates to a cosmetic composition for improving skin wrinkles comprising an extract of Omija as an active ingredient.
  • the extract of Omija of the present invention is excellent in collagenase inhibitory activity, and in particular, it is more effective than the extract of Omija extract or collagenase Inhibitory activity, and the effect of Omiza leaf extract on pro-MMP-1 expression is further reduced than that of Omiza fruit extract. Therefore, the extract of Omima leaf or stem of the present invention can be applied to a cosmetic for improving skin wrinkles or a health functional food.
  • FIG. 1 shows the results of cytotoxicity of extracts (fruit, stem and leaf) extracts according to the present invention.
  • FIG. 2 shows the results of confirming the collagenase inhibitory activity (%) of the extracts of Omija (fruit, stem and leaf) according to the present invention.
  • EGCG epigallocatechin gallate
  • FIG. 3 shows the effect of reducing the expression level of Pro-MMP-1 according to the treatment of Omiza and Omiza leaf extracts.
  • P ⁇ 0.01, **, **, *** indicate that the expression level of Pro-MMP-1 in the TNF- ⁇ -treated group was statistically significantly increased compared with the normal group
  • the expression level of Pro-MMP-1 in the experimental group treated with Schizandra chinensis L. or Leaf extract compared to the group treated with TNF- ⁇ was statistically significantly decreased, p ⁇ 0.05, ** p ⁇ 0.01 , *** is p ⁇ 0.001.
  • the present invention relates to a cosmetic composition for improving skin wrinkles comprising an extract of Omija as an active ingredient.
  • the above-mentioned Omiza extract is preferably a leaf, a stem or a mixed extract thereof of Omija, but is not limited thereto.
  • wrinkle formation is caused by reduction of collagen, and reduction of the collagen may be caused by excessive oxidative stress or ultraviolet irradiation.
  • the above-mentioned Omiza extract has a collagenase inhibitory activity.
  • the Omiza extract may be prepared by a method including, but not limited to, the following steps:
  • step (3) The step of extracting the filtered Schizandra chinensis from step (2) is concentrated under reduced pressure and dried to produce an extract of Schizandra chinensis.
  • the extraction solvent is preferably selected from water, a C 1 -C 4 lower alcohol or a mixture thereof, more preferably ethanol, even more preferably 70% (v / v) ethanol But is not limited thereto.
  • any conventional method known in the art such as filtration, hot water extraction, immersion extraction, reflux cooling extraction, and ultrasonic extraction may be used.
  • the extraction solvent is preferably added by 1 to 20 times the weight of dried omiza, more preferably 5 to 15 times.
  • the extraction temperature is preferably 4 to 50 ° C, but is not limited thereto.
  • the extraction time is preferably 0.5 to 10 hours, more preferably 0.5 to 5 hours, most preferably 1 hour, but not always limited thereto.
  • the drying is preferably performed under reduced pressure, vacuum drying, boiling, spray drying or freeze drying, but not always limited thereto.
  • the cosmetic composition according to one embodiment of the present invention may be used as an external ointment for skin, a cream, a softening agent, a nutritional lotion, a pack, an essence, a hair tonic, a shampoo, a rinse, a hair conditioner, a hair treatment, a gel, a skin lotion, Toner, Astringent, Lotion, Milk Lotion, Moisture Lotion, Nutrition Lotion, Massage Cream, Nourishing Cream, Moisture Cream, Hand Cream, Foundation, Nutrition Essence, Sunscreen, Soap, Cleansing Foam, Cleansing Lotion, Cleansing Cream, Body Lotion and Body And a cleanser.
  • the cosmetic composition comprising each of these formulations may contain various bases and additives necessary for formulation of the formulation, and the kinds and amounts of these ingredients can be easily selected by those skilled in the art.
  • the formulation of the cosmetic composition of the present invention is a paste, a cream or a gel, an animal fiber, a plant fiber, a wax, a paraffin, a starch, a tragacanth, a cellulose derivative, a polyethylene glycol, a silicone, a bentonite, Etc. may be used.
  • lactose When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, Propellants such as hydrocarbons, propane-butanes or dimethyl ethers.
  • a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.
  • the formulation of the cosmetic composition of the present invention is a suspension
  • a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
  • the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, acethionate, imidazolinium derivative, methyltaurate, sarcosinate , Fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolenic derivative or ethoxylated glycerol fatty acid ester.
  • the cosmetic composition of the present invention may further contain an excipient including a fluorescent substance, a fungicide, a hygroscopic substance, a moisturizer, a fragrance, a fragrance carrier, a protein, a solubilizer, a sugar derivative, a sunscreen, a vitamin, .
  • an excipient including a fluorescent substance, a fungicide, a hygroscopic substance, a moisturizer, a fragrance, a fragrance carrier, a protein, a solubilizer, a sugar derivative, a sunscreen, a vitamin, .
  • the cosmetic composition of the present invention can be directly applied to skin using biodegradable micro needles or patches.
  • the present invention also relates to a health functional food composition for preventing or improving skin wrinkles containing an extract of Omija as an active ingredient.
  • the health functional food composition of the present invention When used as a food additive, the health functional food composition may be added as it is, or may be used together with other food or food ingredients, and suitably used according to a conventional method.
  • the amount of the active ingredient to be mixed can be suitably used depending on the purpose of use (prevention or improvement).
  • the health functional food composition of the present invention is added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight based on the raw material, when the food or beverage is produced.
  • the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount of more than the above range.
  • the kind of the health functional food There is no particular limitation on the kind of the health functional food.
  • foods to which the health functional food composition can be added include meat products, sausages, breads, chocolate, candies, snacks, confectionery, pizza, ramen noodles, other noodles, gums, dairy products including ice cream, various soups, Alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense.
  • the health functional food composition of the present invention can be produced as a food, particularly a functional food.
  • the functional food of the present invention includes components that are ordinarily added in food production, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings.
  • the active ingredient when it is made of a drink, it may contain, in addition to the active ingredient, a natural carbohydrate or a flavoring agent as an additional ingredient.
  • the natural carbohydrate may be selected from the group consisting of monosaccharides (e.g., glucose, fructose, etc.), disaccharides (e.g., maltose, sucrose, etc.), oligosaccharides, polysaccharides (e.g., dextrin, cyclodextrin, For example, xylitol, sorbitol, erythritol, etc.).
  • the flavoring agent may be a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.).
  • the above health functional food composition it is also possible to use various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, preservatives, glycerin, A carbonating agent used in beverages, and the like.
  • the ratio of the above-mentioned ingredients is not critical, it is generally selected in the range of 0.01 to 0.1 part by weight based on 100 parts by weight of the health functional food composition of the present invention.
  • the present invention also relates to a quasi-drug composition for preventing or improving skin wrinkles containing an extract of Omija as an active ingredient.
  • the "quasi-drug composition” is a fiber, a rubber product or the like used for treating, alleviating, treating or preventing a disease of a human or an animal, Or products similar to those which are not machinery, preparations used for sterilization, insecticides and similar uses for the prevention of infections, for the purpose of diagnosis, treatment, alleviation, treatment or prevention of diseases of human beings or animals Means an article other than an apparatus, a machine or an apparatus, and an article other than an apparatus, a machine or an apparatus used for the purpose of giving a pharmacological effect to the structure and function of a person or an animal, But not limited to, personal hygiene products.
  • the quasi-drug composition of the present invention may be contained at various weight%, preferably 0.00001 to 10% by weight, as long as it can exhibit a skin wrinkle-reducing effect.
  • MC / 9 cells were diluted for each concentration for 24 hours, and cell viability was measured at 550 nm using a microplate reader (Molecular Devices, Sunnyvale, Calif., USA) using the MTT assay.
  • the collagenase inhibitory activity was determined by adding 4 mM CaCl 2 to 0.1M tris-HCl buffer (pH 7.5) in a reaction vessel and adding 4-phenylaz-o-benzyloxycarbonyl-Pro-Leu-Gly-Pro- ), 0.15 ml of collagenase (0.2 mg / ml) was added to a mixture of 0.25 ml of the substrate solution and 0.1 ml of the solution of each concentration (100, 200, 400, 800 and 1200 / / ml) After standing, 0.5 ml of 6% citric acid was added to quench the reaction. 1.5 ml of ethyl acetate was added and the absorbance at 320 nm was measured. The collagenase inhibitory activity was calculated as the absorbance reduction rate of the sample solution added and the non-added sample.
  • the extract of the present invention inhibited collagenase activity.
  • the extract of the omija leaf or stem showed statistically significant collagenase activity Respectively.
  • both the Omiza fruit and leaf extract had an effect of reducing the expression amount of Pro-MMP-1 increased by TNF- ⁇ , and in particular, the Omiza leaf extract was lower MMP-1 < SEP >

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Abstract

La présente invention concerne une composition qui contient du Schisandra chinensis à titre de substance principale et sert à prévenir et à améliorer les rides de la peau. L'extrait de Schisandra chinensis selon la présente invention fait preuve une excellente activité d'inhibition de la collagénase. En particulier, les extraits de feuilles et de tiges de Schisandra chinensis ont une activité d'inhibition de la collagénase supérieure à un extrait de fruit de Schisandra chinensis et l'extrait de feuilles de Schisandra chinensis a un effet plus important dans la réduction de l'expression de Pro-MMP-1 que l'extrait de fruit de Schisandra chinensis. Par conséquent, la composition selon la présente invention peut être utilisée pour un bon effet dans une composition cosmétique destinée à améliorer les rides de la peau et peut également être utilisée comme aliment de santé fonctionnel pour améliorer les rides de la peau à titre d'aliment de beauté.
PCT/KR2018/015746 2017-12-22 2018-12-12 Composition améliorant les rides de la peau et contenant un extrait de schisandra chinensis à titre de substance active Ceased WO2019124862A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170177767A KR101907921B1 (ko) 2017-12-22 2017-12-22 오미자 추출물을 유효성분으로 포함하는 피부 주름의 예방 또는 개선용 조성물
KR10-2017-0177767 2017-12-22

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WO2019124862A1 true WO2019124862A1 (fr) 2019-06-27

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101907921B1 (ko) * 2017-12-22 2018-10-16 한국 한의학 연구원 오미자 추출물을 유효성분으로 포함하는 피부 주름의 예방 또는 개선용 조성물
KR102196158B1 (ko) 2019-04-01 2020-12-29 박신호 오미자씨 오일을 포함하는 피부 미백 또는 주름 개선용 화장료 조성물
KR102576662B1 (ko) * 2021-10-15 2023-09-08 주식회사 하람 흑오미자 추출물을 유효성분으로 함유하는 환경호르몬에 의해 손상된 피부상태 개선용 조성물
KR102576659B1 (ko) * 2021-10-15 2023-09-08 주식회사 하람 흑오미자 추출물을 유효성분으로 함유하는 피부상태 개선용 조성물

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