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WO2019123746A1 - Système de régulation de température - Google Patents

Système de régulation de température Download PDF

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Publication number
WO2019123746A1
WO2019123746A1 PCT/JP2018/034785 JP2018034785W WO2019123746A1 WO 2019123746 A1 WO2019123746 A1 WO 2019123746A1 JP 2018034785 W JP2018034785 W JP 2018034785W WO 2019123746 A1 WO2019123746 A1 WO 2019123746A1
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WO
WIPO (PCT)
Prior art keywords
liquid
temperature
pipette tip
temperature control
control system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/034785
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English (en)
Japanese (ja)
Inventor
貴紀 村山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Konica Minolta Inc
Original Assignee
Konica Minolta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Inc filed Critical Konica Minolta Inc
Priority to JP2019560802A priority Critical patent/JP7212632B2/ja
Publication of WO2019123746A1 publication Critical patent/WO2019123746A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to a temperature control system applied to a device that performs an appropriate analysis process using a pipette tip and a reaction container.
  • the temperature in the sensor chip is a reagent to be introduced in order to sequentially introduce a reagent such as a reaction solution or a washing solution into the sensor chip.
  • a reagent such as a reaction solution or a washing solution into the sensor chip.
  • the temperature in the sensor chip is greatly influenced by the temperature of the reagent to be used, it is necessary to control the temperature of the reagent.
  • the reagent temperature various cases are assumed such as after being adapted to the ambient temperature, that is, the temperature of the measurement environment (hereinafter referred to as ambient temperature) or immediately after taking it out of the storage (refrigerator), and used for each measurement
  • the liquid temperature may be different. This affects system performance such as measurement repeatability.
  • an analyzer described in Patent Document 1 determines a heater setting value for bringing the reaction unit to a desired temperature based on the ambient temperature and the temperature gradient between the position at which the ambient temperature is measured and the reaction unit, and sets the obtained temperature as a target value. Also, the temperature control unit is feedback controlled using the temperature detected by the second temperature sensor as an output value.
  • an analyzer described in Patent Document 2 comprises a plurality of storage tanks capable of separately storing a reagent, a diluent, a washing solution, or a buffer for reacting with a sample (specimen) such as an antibody, a sample, and an appropriate liquid (reaction liquid).
  • a sample such as an antibody, a sample, and an appropriate liquid (reaction liquid).
  • the cartridge having the reaction vessel for reacting is held on the stage formed by the heat block, and the temperature and heating time of the heat block are controlled to raise the reagents in the cartridge to the target temperature (reaction temperature) It is a thing.
  • the reaction vessel is also temperature-controlled by the heat block.
  • an automatic dispensing method described in Patent Document 3 is known.
  • the pipette tip is inserted into a box-like heating device in which a heater and a fan are disposed and a pipette tip insertion hole is formed on the upper surface, and the pipette tip is heated. It is a method of heating a liquid.
  • the initial temperature is also different for each measurement, so the saturation time is not constant There's a problem.
  • An object of the present invention is to provide a temperature control system capable of performing stable temperature control of liquids such as reagents without being affected by ambient temperature.
  • the present invention includes the following matters.
  • the temperature control system wherein the pump tip performs suction and discharge repeatedly in a state in which the pipette tip is lowered by the drive unit and the temperature control unit performs air flow.
  • the temperature control system according to [1] comprising: a stage temperature control heater configured to heat the stage.
  • the temperature control unit A housing capable of containing at least a portion of the pipette tip; A heat source disposed inside the housing; The temperature control system according to [1] or [2], further comprising: an opening formed in the housing for permitting vertical movement of the pipette tip.
  • the test cartridge includes a reaction container for reacting a reagent and a sample, The suction and discharge are performed in a preheating step of heating the liquid in the storage tank prior to the reaction in the reaction container, The temperature control system according to [2] or [3], wherein the liquid sucked into the pipette tip lastly in the suction and discharge of the preheating stage is discharged to the storage tank containing the liquid.
  • the aspiration and discharge are performed in a measurement step of measuring a reaction between a reagent and a sample in the reaction container,
  • the temperature control system according to [4] wherein the liquid sucked into the pipette tip last in the suction and discharge of the measurement step is discharged to the reaction container.
  • the temperature control system according to [5] wherein the suction and discharge of the liquid is performed in the reaction container.
  • a liquid temperature acquisition unit for acquiring the temperature of the liquid The temperature control system according to [5] or [6], further comprising: a determination unit that determines at least one of necessity of suction and discharge and condition change using the temperature acquired by the liquid temperature acquisition unit.
  • thermocontrol system capable of performing stable temperature control of liquids such as reagents without being affected by ambient temperature.
  • FIG. 3 is a view corresponding to FIG. 2 in a state where the pipette nozzle in the embodiment is lowered by a predetermined distance from a reference position.
  • the temperature control system X is applied to, for example, the analyzer 1 shown in FIG.
  • the analyzer 1 is a device for analyzing a sample by using a pipette tip 51 which is used to suction the reagents and the sample in the storage tank 21 and discharge the reagent and the sample into the reaction container 3 for reaction.
  • the test cartridge 2 in the present embodiment is a container having a storage tank 21 in which necessary reagents such as a labeled antibody and a washing solution are prepackaged individually, and a reaction container 3 in which the reagents and the sample are reacted.
  • the reaction vessel 3 may be a separate part independent of the test cartridge 2.
  • the test cartridge 2 is mounted on a stage 4 (see FIG. 2) of the analyzer 1 in a state where a sample containing a substance to be detected is dispensed in a predetermined storage tank 21 in advance.
  • the sample include blood, serum, plasma, urine, nasal fluid, saliva, semen and the like.
  • examples of the substance to be detected include nucleic acids (such as DNA and RNA), proteins (such as polypeptides and oligopeptides), amino acids, carbohydrates, lipids, and modified molecules thereof.
  • the inspection cartridge 2 schematically shown in FIG. 1 is mounted on the stage 4.
  • the stage 4 is fixed on, for example, a slide base 41 as shown in FIGS. 1 and 2.
  • the stage drive unit not shown
  • the stage 4 moves horizontally while holding the inspection cartridge 2.
  • the reaction container 3 has a container 31 capable of containing a liquid, and the liquid is injected or removed from the container 31 through the tip 511 of the pipette tip 51 inserted from the upper opening of the container 31. is there.
  • a sample containing a substance to be analyzed and reagents (reaction reagents) containing a substance that causes an antigen-antibody reaction with the substance to be analyzed are dispensed into the storage portion 31 of the reaction container 3. Then, after dispensing processing, information on the presence or absence and degree of aggregation, color development, fluorescence, etc. generated as a result of the reaction generated in the reaction container 3 is acquired by an appropriate means, and the acquired data are used to It is possible to carry out the analysis.
  • the analyzer 1 includes at least a liquid sending unit 5 that sucks and discharges liquid in the storage unit 31 of the reaction container 3 and a control unit 6 that controls the operation of the liquid sending unit 5.
  • the liquid delivery unit 5 has a pipette nozzle 52 to which a pipette tip 51 is attached at its tip, a pump 53 connected to the pipette nozzle 52, and a nozzle drive unit 54 (drive unit) that moves the pipette nozzle 52 up and down.
  • each part with which the analyzer 1 is equipped except the stage 4, the liquid feeding part 5, and the control part 6 is abbreviate
  • the pump 53 includes a syringe 531 and a plunger 532 that can reciprocate in the syringe 531, and reciprocates the plunger 532 by a pump drive unit (not shown) including a drive motor (for example, a stepping motor).
  • a pump drive unit including a drive motor (for example, a stepping motor).
  • An external liquid is sucked into the pipette tip 51 or a liquid in the pipette tip 51 is discharged to the outside by reciprocating such a plunger 532 in a state of being connected to the pipette nozzle 52 through the pipe 55, for example.
  • the treatment can be performed quantitatively.
  • the nozzle drive unit 54 freely moves the pipette nozzle 52 in the axial direction (vertical direction in the present embodiment) by, for example, a solenoid actuator or a stepping motor.
  • each unit constituting the liquid delivery unit 5 is configured to be united and handled as a sampler unit 5U.
  • the temperature control system X heats the pipette tip temperature control unit 7 (temperature control unit) that heats the pipette tip 51 and the reaction container 3.
  • a reaction container temperature control unit 8 is provided.
  • the reaction container temperature control unit 8 is configured using a stage temperature control heater 81 that heats the stage 4. By heating the stage 4 by the stage temperature control heater 81, the reaction vessel 3 disposed on the stage 4 can be heated. In the present embodiment, the temperature of the stage 4 heated by the stage temperature control heater 81 can be detected by an appropriate sensor.
  • the pipette tip temperature control unit 7 intensively heats at least the tip portion of the pipette tip 51 of the pipette nozzles 52 positioned at a predetermined heating position by the warm air released from the heat source 72.
  • the pipette tip temperature control unit 7 includes a housing 71 capable of housing at least the tip portion of the pipette tip 51, and a heat source 72 disposed inside the housing 71.
  • a fan 73 for sending warm air discharged from the heat source 72 in a predetermined direction is provided, and the internal space of the housing 71 is heated by the warm air discharged from the heat source 72.
  • the housing 71 has a box-like shape, and an upper wall 711 and a lower wall 712 of the outer wall that partitions the internal space from the outside form an opening that allows the pipette tip 51 to move up and down.
  • insertion holes (upper insertion holes 713 and lower insertion holes 714) through which the pipette tip 51 can be inserted are applied as the opening.
  • the casing 71 is configured using a bottomed casing main body 715 having a large opening at the upper side, and a top plate 716 disposed at a position closing the upper opening of the casing main body 715. .
  • the upper insertion hole 713 of the casing 71 is a round hole formed in the top plate 716
  • the lower insertion hole 714 of the casing 71 is a round hole formed in the bottom of the casing main body 715.
  • the upper insertion hole 713 and the lower insertion hole 714 are in a positional relationship opposed in the vertical direction (the moving direction of the pipette nozzle 52).
  • the pipette tip temperature control unit 7 applies warm air discharged from the heat source 72 to the pipette tip 51 inserted into the internal space of the housing 71 through the upper insertion hole 713 and the lower insertion hole 714.
  • the pipette tip 51 can be heated.
  • a sensor 717 for example, a thermistor
  • the radiation fin 718 equipped with a thermal fuse functions as a safety device.
  • the fan 73 can also be disposed in the internal space of the housing 71.
  • the fan 73 is outside the housing 71 and on the outer wall (side wall in the illustrated example) of the housing 71. It is fixed at a position facing the formed fan opening 719 so that the warm air discharged from the heat source 72 can be sent in a predetermined direction by the fan 73.
  • the size of the casing 71 is narrowed, and the temperature of the internal space of the casing 71 is raised to a predetermined target temperature set in advance by the warm air. ⁇ Processing to keep warm can be performed efficiently.
  • the pipette tip temperature control unit 7 is unitized in a state where the bracket 74 is fixed to the housing 71. Then, by attaching the bracket 74 to the sampler unit 5U, the pipette tip temperature control unit 7 can be fixed to the sampler unit 5U (see FIG. 2).
  • the pipette tip temperature control unit 7 is disposed in the vicinity of the reaction container 3. Specifically, as shown in FIG. 4, the separation distance (the distance indicated by “L” in FIG. 4) from the lower end (bottom of the housing 71) of the pipette tip temperature control unit 7 to the top surface of the reaction container page is For example, it is set to about 5 mm.
  • the flow of the warm air generated from the heat source 72 of the pipette tip temperature control unit 7 is schematically indicated by a relatively thick arrow.
  • the control unit 6 is constituted by, for example, a known computer or microcomputer including an arithmetic unit, a control unit, a storage unit, an input unit, an output unit and the like, and the liquid sending unit 5, the pipette tip temperature adjustment unit 7, the reaction container temperature adjustment
  • the operation of each part of the analyzer 1 including the part 8 is controlled according to a predetermined program.
  • the control unit 6 acquires a pipette tip temperature acquisition unit 61 that acquires the temperature in the housing 71 constituting the pipette tip temperature adjustment unit 7 from the sensor 717, and a reaction container temperature acquisition that acquires the temperature of the reaction container 3 And a unit 62.
  • the temperature of the reaction vessel 3 is indirectly acquired by acquiring the temperature of the stage 4.
  • the temperature control system X of the analyzer 1 starts the measurement using the test cartridge 2 by the analyzer 1 and during the detection process of the substance to be detected, the reaction container temperature controller 8 by the controller 6 And temperature control of the pipette tip temperature control unit 7 is executed.
  • the control unit 6 performs temperature acquisition processing by the pipette tip temperature acquisition unit 61 and the reaction container temperature acquisition unit 62 at an appropriate timing, and based on the acquired temperature, the pipette tip temperature adjustment temperature by the pipette tip temperature adjustment unit 7
  • the reaction container temperature control unit 8 adjusts the reaction container temperature control temperature (stage temperature control temperature) to a preset pipette tip temperature control target temperature and reaction container temperature control target temperature (stage temperature control target temperature). Control.
  • the pipette tip temperature control target temperature and the reaction container temperature control target temperature may be the same or different.
  • the reaction container temperature control target temperature stage temperature control target temperature
  • the pipette tip temperature control target temperature is aspirated and discharged by the pipette tip
  • the effect that the temperature does not fall can be expected, and the adverse effect on the reagent and the thermal deformation of the pipette tip itself can be set to a temperature that can be avoided.
  • control unit 6 includes a liquid temperature acquisition unit 63 that acquires the temperature of the liquid contained in the storage tank 21.
  • the control unit 6 uses the temperature of the reaction container 3 acquired by the reaction container temperature acquisition unit 62 and the temperature of the liquid acquired by the liquid temperature acquisition unit 63 to change the necessity of suction and discharge described later, the suction and discharge conditions, etc.
  • a thermopile, a contact type thermistor, etc. can be considered as an example of a sensor which acquires the temperature of reaction container 3, and the temperature of a liquid.
  • the temperature control system X of this embodiment accommodates at least the tip portion of the pipette tip 51 inside the housing 71 with the pipette nozzle 52 positioned at a predetermined heating position. It is configured to be. Specifically, in the state where the pipette nozzle 52 is positioned at the heating position, the tip 511 of the pipette tip 51 is positioned in the lower insertion hole 714 of the housing 71, and from the tip of the pipette tip 51 to a predetermined dimension Is set so as to be disposed inside the housing 71. In the present embodiment, the origin position of the pipette nozzle 52 is set to the “heating position”. Therefore, the tip portion of the pipette tip 51 can be heated inside the housing 71 by making the pipette nozzle 52 stand by at the origin position.
  • a predetermined gap is formed between the tip 511 of the pipette tip 51 and the lower insertion hole 714, and the pipette tip 51 and the upper insertion hole A predetermined gap is also formed between 713, and the pipette tip 51 is set so as not to contact the housing 71. From the gap between the pipette tip 51 and the insertion hole (upper insertion hole 713, lower insertion hole 714), the warm air in the housing 71 blows out to the outside of the housing 71, and the ambient temperature of the housing 71 is The internal temperature of the housing 71 can be maintained at the same level (see FIG. 4).
  • the process at the time of using the temperature control system X of the analyzer 1 which concerns on this embodiment is demonstrated.
  • the inspection cartridge 2 stored at a temperature of about 2 to 8 ° C. is taken out of the refrigerator (not shown) by the user.
  • the temperature of the inspection cartridge 2 is returned to the room temperature of about 10 to 30.degree.
  • the inspection cartridge 2 is mounted on the stage 4 heated by the stage temperature control heater 81 which is the reaction container temperature control unit 8.
  • the stage temperature control heater 81 which is the reaction container temperature control unit 8.
  • each storage tank 21 of the test cartridge 2 and the storage section 31 of the reaction container 3 are also heated on the stage 4, and the liquid to be sucked stored in each storage tank 21 is also heated. That is, prior to the reaction between the reagent and the sample in the storage unit 31 of the reaction container 3, preheating is performed to heat the liquid in the storage tank 21.
  • the preheating time is preferably about 1 to 10 minutes.
  • the process proceeds to the measurement step of measuring the reaction between the reagent and the sample in the storage unit 31 of the reaction container 3.
  • the control unit 6 drives the stage drive unit (not shown) to move the stage 4 to a position where the storage tank 21 containing the liquid to be sucked is directly below the pipette nozzle 52.
  • control unit 6 causes the pipette tip temperature control unit 7 to release warm air from the heat source 72, and heats the pipette nozzle 52 located at the heating position. Hot air of a temperature of 30 to 60 ° C. is released from the heat source 72.
  • the control unit 6 drives the nozzle drive unit 54 to lower the pipette nozzle 52 from the heating position, and sucks the liquid of the test cartridge 2 into the pipette tip 51. Specifically, in a state where the pipette nozzle 52 is lowered by a predetermined distance from the heating position and stopped, the control unit 6 drives the pump 53 to suction from the tip of the pipette nozzle 52, that is, the tip 511 of the pipette tip 51 Aspirate the target fluid.
  • the control unit 6 discharges the liquid sucked into the pipette nozzle 52 from the tip 511 into the storage tank 21 by the pump 53 in this state.
  • the controller 6 sucks the liquid in the storage tank 21 again into the pipette tip 51 by the pump 53 and discharges the liquid into the storage tank 21.
  • suction and discharge repeating suction and discharge of liquid by the pipette tip 51 is referred to as "suction and discharge".
  • the tip portion of the pipette tip 51 is pulled out of the casing 71 of the pipette tip temperature control unit 7 and exposed to the external ambient temperature, but the ambient temperature of the casing 71 is an insertion portion with the pipette tip 51
  • the hot air in the casing 71 is sprayed to the outside of the casing 71 from the gap between the holes (upper insertion holes 713 and lower insertion holes 714), and the temperature is maintained at about the same as the internal temperature of the casing 71.
  • the distal end portion of the pipette tip 51 is also heated by the warm air in a state of being detached from the housing 71 of the pipette tip temperature control unit 7.
  • the liquid in which storage tank 21 is sucked and discharged may be determined according to the amount of liquid in each storage tank 21 or the like. Further, suction and discharge may be performed on the liquid in all the storage tanks 21, and suction and discharge may be performed on only the liquid in the selected storage tank 21.
  • the tip of the pipette tip 51 is disposed in the housing 71, and the pipette tip temperature control unit 7
  • the liquid is heated directly. From the heat source 72, warm air at a temperature suitable for the reaction of 30 ° C. or more and 40 ° C. or less is emitted for 30 seconds or more and 300 seconds or less.
  • the gas may be continuously released from the heat source 72 at a temperature of 40 ° C. or more and 60 ° C. or less for 10 seconds or more and 120 seconds or less to rapidly heat the liquid at a high temperature.
  • the liquid since the liquid is previously pulled up to a predetermined temperature by suction and discharge, when heating in the housing 71, the heating of the liquid is accelerated, and the liquid is heated to the target temperature in a short time can do.
  • control unit 6 drives the stage drive unit to discharge the liquid held in the pipette tip 51, specifically, the storage tank 21 of the inspection cartridge 2 or the storage unit 31 of the reaction container 3
  • the stage 4 is moved to a position immediately below the pipette nozzle 52.
  • the control unit 6 drives the pump 53 to drive the tip of the pipette nozzle 52, that is, the tip of the pipette tip 51 From 511, the liquid in the pipette tip 51 is discharged toward the discharge destination.
  • the discharge destination is the storage portion 31 of the reaction container 3
  • the liquid sucked into the pipette tip 51 at the end of the suction and discharge discharges the storage portion 31 of the reaction container 3.
  • the operation from the above-mentioned suction and discharge to the discharge of the liquid toward the discharge destination is, for example, the type of liquid to be targeted in the order of the measurement liquid, diluted sample, washing liquid, labeled antibody, washing liquid, and measurement liquid. It will be repeated instead.
  • suction and discharge in the state where the pipette tip 51 is heated with warm air are performed on the dilution solution.
  • the cleaning liquid since the cleaning liquid is particularly used in a large amount and it is difficult to heat it, it is useful to perform the above-mentioned suction and discharge in advance to heat it to a predetermined temperature.
  • the liquid discharged into the storage portion 31 of the reaction container 3 may be further absorbed and discharged. After the measurement of the reaction between the reagent and the sample in the storage unit 31 of the reaction container 3 is performed, the measurement step ends.
  • the temperature control system X before the liquid is discharged to the storage unit 31 by performing suction and discharge in a state in which the pipette tip 51 is heated with warm air to the target liquid.
  • the pipet tip 51 can be sucked and discharged in a state of being heated by warm air in advance and can be raised beforehand to a predetermined temperature, stable liquid temperature control can be performed without being affected by the ambient temperature. Can.
  • the warm air from the heat source 72 may be discharged from any direction as long as the warm air can be blown to the tip end 511 of the pipette tip 51 at the position where the pipette tip 51 descends.
  • the heat source 72 may be provided at the top of the housing 71 and the warm air may be discharged from the heat source 72 in the axial direction of the pipette tip 51.
  • a plurality of heat sources 72 may be disposed so as to surround the pipette tip 51, and warm air may be blown around the entire circumference of the pipette tip 51.
  • the heat source 72 was provided in the inside of the housing
  • the pipette tip 51 sucks the liquid in the storage tank 21 and discharges it to the storage section 31.
  • suction and discharge may be performed in the preheating in which the stage 4 is heated in advance. In this case, the liquid sucked into the pipette tip 51 at the end of suction and discharge in the preheating stage is discharged to the storage tank 21 containing the liquid.
  • the temperature of the reaction container 3 may be acquired by the reaction container temperature acquisition unit 62 or the temperature of the liquid may be acquired by the liquid temperature acquisition unit 63 in the preheating stage or the measurement stage.
  • the temperature of the liquid and the temperature of the reaction container 3 may be measured during suction and discharge in the measurement stage. It is desirable to acquire and control pumping.
  • the control unit 6 changes the necessity of suction and discharge and change the suction and discharge conditions based on at least one of the temperature of the reaction container 3 acquired by the reaction container temperature acquisition unit 62 and the temperature of the liquid acquired by the liquid temperature acquisition unit 63. Determine For example, when it is determined that there is no need for suction and discharge, such as when the temperature of the liquid reaches a target temperature, the control unit 6 stops the suction and discharge, and when it is determined that there is a need for suction and discharge. Continue to suck and discharge.
  • the suction and discharge conditions include, for example, the duration of suction and discharge, the amount of liquid sucked and discharged by the pipette tip 51, and the like.
  • the suction and discharge duration time is 0.5 minutes or more and 5 minutes or less if repetition of the suction and discharge is 11 to 50 times.
  • the liquid volume of the liquid absorbed and discharged by the pipette tip 51 is 50 ⁇ l or more and 300 ⁇ l or less, preferably 50 ⁇ l or more and 200 ⁇ l or less.
  • the control unit 6 appropriately changes these suction and discharge conditions based on the determination result. Thereby, temperature control of the liquid can be performed more accurately.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
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  • General Physics & Mathematics (AREA)
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Abstract

L'invention concerne un système de régulation de température (X) comprenant une unité d'entraînement (54) qui élève et abaisse une pointe de pipette (51), une unité de régulation de température (7) qui souffle de l'air sur la pointe de pipette (51) et une pompe permettant d'aspirer un liquide dans la pointe de pipette (51) et d'évacuer le liquide à l'intérieur de la pointe de pipette (51), le système de régulation de température (X) permettant de réaliser une régulation de température stable du liquide, par exemple un réactif, sans être affecté par la température ambiante, par la réalisation d'une aspiration et d'une évacuation au cours desquelles la pompe (53) répète l'aspiration et l'évacuation dans un état dans lequel la pointe de pipette (51) a été abaissée par l'unité d'entraînement (54) et l'air a été soufflé par l'unité de régulation de température (7).
PCT/JP2018/034785 2017-12-21 2018-09-20 Système de régulation de température Ceased WO2019123746A1 (fr)

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JP2019560802A JP7212632B2 (ja) 2017-12-21 2018-09-20 温調システム

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JP2017244991 2017-12-21
JP2017-244991 2017-12-21

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WO2019123746A1 true WO2019123746A1 (fr) 2019-06-27

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3779459A4 (fr) * 2018-04-05 2021-05-05 Konica Minolta, Inc. Système et procédé de réglage de température
US12050232B2 (en) 2021-12-31 2024-07-30 Instrumentation Laboratory Company Systems and methods for probe tip heating

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JPH07209306A (ja) * 1994-01-11 1995-08-11 Toshiba Corp 自動化学分析装置用試薬分注システム
JPH1094535A (ja) * 1996-09-25 1998-04-14 Teruaki Ito 検体分取分注装置
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WO2016132945A1 (fr) * 2015-02-20 2016-08-25 コニカミノルタ株式会社 Procédé de réaction et dispositif de réaction
WO2017082142A1 (fr) * 2015-11-13 2017-05-18 コニカミノルタ株式会社 Système d'inspection
WO2017082069A1 (fr) * 2015-11-13 2017-05-18 コニカミノルタ株式会社 Procédé de réaction
WO2018163990A1 (fr) * 2017-03-06 2018-09-13 コニカミノルタ株式会社 Système de régulation de température

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Publication number Priority date Publication date Assignee Title
JPS5858471A (ja) * 1981-10-02 1983-04-07 Toshiba Corp 自動生化学分析装置における撹拌装置
JPH06289032A (ja) * 1993-04-01 1994-10-18 Toshiba Corp 自動分析装置の分注方法および分注システム
JPH07209306A (ja) * 1994-01-11 1995-08-11 Toshiba Corp 自動化学分析装置用試薬分注システム
JPH1094535A (ja) * 1996-09-25 1998-04-14 Teruaki Ito 検体分取分注装置
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US12117460B2 (en) 2018-04-05 2024-10-15 Otsuka Pharmaceutical Co., Ltd. Temperature adjustment system and temperature adjustment method
US12050232B2 (en) 2021-12-31 2024-07-30 Instrumentation Laboratory Company Systems and methods for probe tip heating

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