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WO2019103641A1 - Procédé de traitement d'implants poreux à base de matériaux métalliques - Google Patents

Procédé de traitement d'implants poreux à base de matériaux métalliques Download PDF

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Publication number
WO2019103641A1
WO2019103641A1 PCT/RU2017/000878 RU2017000878W WO2019103641A1 WO 2019103641 A1 WO2019103641 A1 WO 2019103641A1 RU 2017000878 W RU2017000878 W RU 2017000878W WO 2019103641 A1 WO2019103641 A1 WO 2019103641A1
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WO
WIPO (PCT)
Prior art keywords
medium
liquid
liquid medium
transition temperature
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2017/000878
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English (en)
Russian (ru)
Inventor
Юрий Николаевич ЛОГИНОВ
Сергей Владимирович БЕЛИКОВ
Степан Игоревич СТЕПАНОВ
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Science and Innovations JSC
Original Assignee
Science and Innovations JSC
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Filing date
Publication date
Application filed by Science and Innovations JSC filed Critical Science and Innovations JSC
Priority to EA201800025A priority Critical patent/EA037685B1/ru
Priority to RU2018101750A priority patent/RU2699337C2/ru
Priority to PCT/RU2017/000878 priority patent/WO2019103641A1/fr
Publication of WO2019103641A1 publication Critical patent/WO2019103641A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/08—Alloys with open or closed pores

Definitions

  • the present invention relates to the field of additive technologies used for the manufacture of implants, preferably from titanium alloys.
  • Implants are preferably made of porous materials. The presence of pores in the material allows to solve several problems:
  • a porous material based on titanium nickelide is obtained by the method of self-propagating high-temperature synthesis from a mixture molded in a cylindrical container.
  • the disadvantage of this method is the uneven distribution of porosity over the volume of the implant due to the fact that the process of self-propagating high-temperature synthesis is not fully controlled, it does not allow you to create a strict architecture of the material.
  • the strength properties of materials are often evaluated by the conditional yield strength of so > 2 , as mechanical stress, at which the residual plastic deformation of the sample under the linear stress state is 0.2%. It should be noted that the conditional yield strength is a function of the degree of deformation, i.e. when hardening, the value of so > 2 increases.
  • the method includes preparing a model of cellular structures and making a cellular structure when exposed to fusible material as an energy source.
  • the cellular structure is formed by curved branches forming cells with a size of 0.01 ... 2000 ⁇ m.
  • the material itself may be a metal or alloy, including titanium or titanium alloy.
  • the disadvantage of the prototype method is a low level of strength properties of the material.
  • the metal obtained from the melt has the properties of annealed material, in the case of the use of titanium, the yield strength is at the level of 500 MPa, which follows, in particular, from formula (1).
  • the present invention is directed to the achievement of the technical result, which consists in increasing the strength properties of the implant.
  • the proposed method of processing porous implants based on metallic materials includes preparing a model of cellular structures and making a cellular structure when exposed to a fusible material as a source of energy.
  • the method is characterized in that after fabrication of the cellular structure, it is immersed in a liquid medium, cooled to a temperature below the temperature of the phase transition of the medium from a liquid to a solid state, subjected to plastic deformation, then heated to a temperature of a phase transition of the medium from a solid to a liquid state and removed liquid medium.
  • Water can be used as a liquid medium, as a substance having a phase transition from a liquid to a solid state at a moderate temperature of 0 ° C.
  • the transition temperature of this melt from solid to liquid should not be higher than the recrystallization temperature of the metallic material so that this material does not soften during the operation of melting salts for their removal from the cellular structure.
  • molten metal or alloy As a liquid medium, you can use a molten metal or alloy as a substance with a sufficient level of plastic properties.
  • FIG. Figure 1 shows the structure of an implant with a circularly shaped cell with a cross-section filled with a substance having a phase transition from a liquid to a solid state at a temperature below such a transition.
  • FIG. 2 shows the cell shape after plastic deformation by sediment.
  • FIG. 3 shows the shape of the cells after carrying out a 90 ° turning and re-settling.
  • FIG. 4 shows the shape of the cells after another 90 ° turn-off and precipitation.
  • Example 1 Carry out the preparation of the model of cellular structures and produce a cellular structure when exposed to fusible material, the source of energy. Titanium is used as a fusible material.
  • the cellular structure is made with open porosity, for example, with the shape of pores in the cross section in the form of circles 1 (FIG. 1), separated by bridges 2.
  • the cellular structure is immersed in a liquid medium, for example, water, cooled to a temperature below the phase transition temperature from the liquid state in solid state, i.e. below 0 ° C. As a result, the water freezes and cannot leave the pores when the preform is removed from the liquid medium.
  • a liquid medium for example, water
  • the height of the structure decreases.
  • An increase in the width of the structure occurs due to the fact that, in general, the structure, in the presence of a medium in the pores, is an incompressible material.
  • the hardening of the material at 100 * (697-500) / 500 39% is achieved.
  • the cellular structure is heated to the temperature of the phase transition of the medium from the solid to the liquid state, for example, for water above 0 ° C and the liquid medium is removed.
  • Example 2 The hardening achieved in the conditions of example 1 can be increased by repeating the precipitation operation. However, it is undesirable to draft in the same direction, since the shape of the workpiece will be significantly changed, and the profile of the cells will greatly extend in one preferred direction and this will lead to increased anisotropy of properties. Therefore, if a solid medium is present in the cells, the billet is turned 90 ° C (Fig. 3) and deposited in the direction of the force R 2 ⁇ As a result, it becomes possible to return to the original shape of the pores (Fig. 4), which ensured that the material is macroisotropic. Based on the calculation by formula (1), it is possible to show a further increase in the strength properties of the material.
  • Example 3 As a liquid medium, you can use a molten salt, having a transition temperature from solid to liquid, not higher than the recrystallization temperature of the metallic material. It is advisable to use salts that do not adversely affect the human body in case they cannot be removed from the implant completely.
  • One of the most compatible with the human body is sodium chloride, with the temperature of the phase transition from a liquid to a solid state: 801 ° C. At temperatures above the indicated saturation of the cellular structure with the melt is possible. At low temperatures, the melt in the cells goes into a solid state and is able to transmit pressure. With further increase in temperature, the salt in the form of a liquid can be removed from the cellular structure.
  • the melting point of the salt material it is possible to mix sodium chloride with other chlorides to create eutectic compounds.
  • sodium chloride and magnesium chloride also a biocompatible salt
  • Example 4 As a liquid medium, you can use a molten metal or alloy from a number of biocompatible materials. As such a metal, zinc can be used, having a low melting point of 420 ° C.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Powder Metallurgy (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne le domaine des techniques additives utilisées dans la fabrication d'implants, de préférence, en alliages de titane. Le procédé de traitement d'implants poreux à base de matériaux métalliques consiste à préparer un modèle de structures alvéolaires et fabriquer une structure alvéolaire en agissant sur un matériau apte à la fusion par une sources d'énergie. Le procédé se distingue en ce que tout de suite après la fabrication d'une structure alvéolaire celle-ci est plongée dans un milieu liquide, refroidie à une température inférieure à celle de la transition de phase de l'étant liquide à l'état solide, soumise à la déformation plastique puis chauffée jusqu'à une température de transition de phase de l'état solide à l'état liquide ; le milieu liquide est ensuite évacué. On utilise en tant que milieux liquide soit un bain de fusion de sels possédant une température de transition de l'état solide à l'état liquide inférieur ou égal à la température de recristallisation de matériau métallique ou le bain de fusion d'un métal ou d'un alliage. Cette invention permet d'améliorer les propriétés de l'implant en termes de sa résistance mécanique.
PCT/RU2017/000878 2017-11-24 2017-11-24 Procédé de traitement d'implants poreux à base de matériaux métalliques Ceased WO2019103641A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EA201800025A EA037685B1 (ru) 2017-11-24 2017-11-24 Способ обработки пористых имплантатов на основе металлических материалов
RU2018101750A RU2699337C2 (ru) 2017-11-24 2017-11-24 Способ обработки пористых имплантатов на основе металлических материалов
PCT/RU2017/000878 WO2019103641A1 (fr) 2017-11-24 2017-11-24 Procédé de traitement d'implants poreux à base de matériaux métalliques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2017/000878 WO2019103641A1 (fr) 2017-11-24 2017-11-24 Procédé de traitement d'implants poreux à base de matériaux métalliques

Publications (1)

Publication Number Publication Date
WO2019103641A1 true WO2019103641A1 (fr) 2019-05-31

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PCT/RU2017/000878 Ceased WO2019103641A1 (fr) 2017-11-24 2017-11-24 Procédé de traitement d'implants poreux à base de matériaux métalliques

Country Status (3)

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EA (1) EA037685B1 (fr)
RU (1) RU2699337C2 (fr)
WO (1) WO2019103641A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438801A1 (fr) * 2001-02-19 2002-08-29 Isotis N.V. Metaux poreux et revetements metalliques pour implants
RU2353474C2 (ru) * 2007-04-23 2009-04-27 Российский химико-технологический университет им. Д.И. Менделеева Способ получения высокопористого материала
RU2401821C2 (ru) * 2004-04-21 2010-10-20 Дау Глобал Текнолоджиз Инк. Способ увеличения прочности пористых керамических изделий и изделия, изготовленные этим способом
US20130011691A1 (en) * 2010-03-31 2013-01-10 Jianming Ruan Porous tantalum used for medical implantation and method for preparing the same
RU2589510C2 (ru) * 2009-08-19 2016-07-10 Смит Энд Нефью, Инк. Пористые структуры имплантатов

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136388A (fr) * 1978-01-09 1982-11-30 Kennecott Corporation Methode de production d'articles en ceramique frittes a l'aide d'un liquide a teneur de bore
RU2623566C1 (ru) * 2016-09-15 2017-06-27 Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" (Госкорпорация "Росатом") Способ изготовления спеченных пористых изделий из псевдосплава на основе вольфрама

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438801A1 (fr) * 2001-02-19 2002-08-29 Isotis N.V. Metaux poreux et revetements metalliques pour implants
RU2401821C2 (ru) * 2004-04-21 2010-10-20 Дау Глобал Текнолоджиз Инк. Способ увеличения прочности пористых керамических изделий и изделия, изготовленные этим способом
RU2353474C2 (ru) * 2007-04-23 2009-04-27 Российский химико-технологический университет им. Д.И. Менделеева Способ получения высокопористого материала
RU2589510C2 (ru) * 2009-08-19 2016-07-10 Смит Энд Нефью, Инк. Пористые структуры имплантатов
US20130011691A1 (en) * 2010-03-31 2013-01-10 Jianming Ruan Porous tantalum used for medical implantation and method for preparing the same

Also Published As

Publication number Publication date
EA037685B1 (ru) 2021-05-04
RU2018101750A3 (fr) 2019-07-24
RU2699337C2 (ru) 2019-09-04
RU2018101750A (ru) 2019-07-18
EA201800025A1 (ru) 2019-05-31

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