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WO2019177211A1 - Dispositif de thérapie par plasma pour le traitement du cancer du col de l'utérus - Google Patents

Dispositif de thérapie par plasma pour le traitement du cancer du col de l'utérus Download PDF

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Publication number
WO2019177211A1
WO2019177211A1 PCT/KR2018/009390 KR2018009390W WO2019177211A1 WO 2019177211 A1 WO2019177211 A1 WO 2019177211A1 KR 2018009390 W KR2018009390 W KR 2018009390W WO 2019177211 A1 WO2019177211 A1 WO 2019177211A1
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WO
WIPO (PCT)
Prior art keywords
plasma
device housing
cervical cancer
treatment
guide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/009390
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English (en)
Korean (ko)
Inventor
권병수
최은하
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Industry Cooperation of Kwangwoon University
Pusan National University Hospital
Original Assignee
Research Institute for Industry Cooperation of Kwangwoon University
Pusan National University Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Industry Cooperation of Kwangwoon University, Pusan National University Hospital filed Critical Research Institute for Industry Cooperation of Kwangwoon University
Publication of WO2019177211A1 publication Critical patent/WO2019177211A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00559—Female reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2277/00—Applications of particle accelerators
    • H05H2277/10—Medical devices

Definitions

  • the present invention relates to a plasma treatment apparatus for treating cervical cancer, and more particularly, to a plasma treatment apparatus for treating cervical cancer precancerous lesions using plasma.
  • Cervical cancer is the fourth most common female cancer in the world. More than half a million cancers were diagnosed worldwide in 2012, of which approximately 50% of patients died from the disease.
  • cervical cancer undergoes a stage of precancerous lesions longer than other cancers, it is a disease that can be cured only by early detection, and it is possible to discriminate abnormalities through simpler tests than diagnostic tests of stomach, lung, colon, and thyroid cancer. Given the fact, early detection and active treatment of cervical precancerous lesions is important.
  • cervical precancerous lesions can cause a sudden increase in incidence in younger ages and severe pregnancy-related complications of conventional resections. Therefore, it is urgent to develop new safe and effective therapies given the low birthrate social situation.
  • Atmospheric pressure plasma is an ionized medium containing active ingredients including electrons and ions, free radicals, reactive molecules and photons, and can be classified as either thermal plasma or non-thermal plasma.
  • non-thermal atmospheric pressure plasmas are emerging as new tools in biomedical applications because they can interact with targeted biomaterials without causing thermal damage to surrounding tissues.
  • Korean Patent Nos. 10-1592081 and 10-1248668 there is no published technique for killing cervical cancer cells using low-temperature atmospheric pressure plasma, and killing of cervical cancer cells using low-temperature atmospheric plasma. The method does not have a publicly available technology, and related technology development is urgently needed.
  • an object of the present invention is to provide a plasma treatment apparatus for treating cervical cancer that can treat precancerous lesions of cervical cancer using plasma.
  • Plasma treatment device for cervical cancer treatment of the present invention for achieving the above object, and a probe-type device housing that can enter the planar neck to treat the cervix;
  • a plasma guide part installed at the distal end of the device housing to guide the plasma generated by the plasma generating part to be concentrated on the cervix side.
  • cervical cancer cells can be killed and treated using plasma energy.
  • the plasma guide portion preferably extends from the edge of the front end of the device housing and includes an outer diameter guide member that surrounds and supports the uterine outer tube.
  • the plasma energy is guided to the uterine cervix to increase the cancer cell eradication effect of the uterine cervix.
  • the plasma guide portion preferably extends to narrow gradually from the rim of the front end of the device housing to include an outer diameter guide member for guiding the plasma energy concentrated in the cervical canal.
  • plasma energy can be concentrated in the endometrial tube, thereby effectively eradicating and treating cancer cells in the endometrial tube.
  • the plasma generating unit may include a low temperature atmospheric dielectric barrier (DBD) plasma.
  • DBD low temperature atmospheric dielectric barrier
  • the plasma treatment apparatus for cervical cancer treatment for achieving the above object, a probe-type device housing which can be entered into the planar to treat cervical cancer; A first plasma generating module installed in the device housing to generate plasma for treating the uterine cervix; And a second plasma generation module installed in the device housing to generate a plasma for treating the endometrial canal.
  • the second plasma generating module is preferably arranged to generate plasma energy to the central portion of the plasma generating surface generated by the first plasma generating module.
  • the plasma cells generated by the second plasma generation module may be used to intensively eradicate cancer cells of the uterine inner diameter.
  • the first plasma generation module may include a low temperature atmospheric dielectric barrier (DBD) plasma.
  • DBD low temperature atmospheric dielectric barrier
  • the second plasma generating module may include a low temperature atmospheric plasma jet capable of intensively generating plasma at a central portion of the tip of the device housing.
  • a relatively large area of the endometrium can be treated using a low temperature atmospheric pressure plasma, and a relatively narrow area of the endometrium can be intensively treated using an atmospheric plasma jet.
  • the apparatus may further include a plasma guide unit installed in the device housing to guide the plasma energy generated by the first and second plasma generating modules to be concentrated to the cervix.
  • the plasma guide part may include an outer diameter guide member which extends from the edge of the tip of the device housing to guide the plasma energy generated by the first plasma generating part to the uterine outer tube.
  • the plasma guide unit may further include an inner diameter guide member connected to a central portion of the front end of the device housing to guide the plasma energy generated by the second plasma generating module to be concentrated into the uterine endoscope.
  • the inner tube guide member is formed so as to protrude in the shape of a nozzle from the center of the front end of the device housing is inserted into the endometrial tube to transmit plasma energy.
  • the low-temperature atmospheric pressure plasma energy is concentrated in the endometrial canal, and the atmospheric pressure plasma jet is guided to the endometrial canal to increase the therapeutic effect.
  • the apparatus may further include an internal structure installed inside the device housing to isolate the first and second plasma generating modules.
  • the first and second plasma generating modules driven independently of each other may be installed in one device housing.
  • the internal structure may include a quartz tube, and a gas supply path may be formed between the quartz tube and the device housing to supply gas to the plasma generator of the first plasma generating module.
  • the plasma treatment apparatus for cervical cancer treatment of the present invention it is possible to effectively treat cervical cancer using plasma energy.
  • the uterine cervix can treat a large area using a large-area plasma generator, and the endometrial canal is provided with a complex treatment device for intensive treatment using a plasma jet. There is an advantage that can be treated at the same time using the treatment device.
  • plasma energy can be concentrated in the uterine cervix and the endometrial tube, thereby improving the therapeutic effect.
  • FIG. 1 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a first embodiment of the present invention.
  • FIG. 2 and 3 are schematic views for explaining and extracting the plasma generating unit shown in FIG.
  • FIG. 4 is a view for explaining a state of treating the endometrial tube using the plasma treatment apparatus shown in FIG.
  • Figure 5 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a second embodiment of the present invention.
  • FIG. 6 is a view for explaining a process of treating an endometrial canal using the plasma treatment apparatus shown in FIG. 5.
  • FIG. 7 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a third embodiment of the present invention.
  • FIG. 8 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a fourth embodiment of the present invention.
  • FIG. 9 is a schematic diagram illustrating a process of treating the cervix using the plasma treatment apparatus for treating cervical cancer shown in FIG. 8.
  • the plasma treatment apparatus 100 for treating cervical cancer according to the first embodiment of the present invention may generate plasma energy to the device housing 110 and the tip of the device housing 110.
  • the device housing 110 is formed of an insulating material and has a tubular shape having a predetermined length.
  • the device housing 110 has a sufficient length to enter the vagina of the uterus for the purpose of treating the cervix, and preferably has a circular tubular structure.
  • a gas supply path 111 may be formed in the device housing 110 to supply gas to the plasma generator 120 installed at the tip of the device housing 110.
  • the gas supply path 111 may be formed between the device housing 110 and the internal structure 113 installed inside the device housing 110.
  • the internal structure 113 may be formed of an insulating material, and may include, for example, a quartz tube.
  • the plasma generation unit 120 may have a structure of a so-called DBD () plasma generation method. That is, as shown in FIGS. 1, 2, and 3, the plasma generating unit 120 is installed at the tip of the device housing 110, and the first electrode 123 is installed on the glass substrate 121. And a dielectric 127 provided on the substrate 121 to insulate the second electrode 125 and the first and second electrodes 123 and 125. A gas supply passage h may be minutely formed in the glass substrate 121 to supply gas toward the electrodes 123 and 125.
  • the first and second electrodes 123 and 125 formed on the substrate 121 may be stacked and formed by a semiconductor manufacturing process, and may be formed in various patterns.
  • the second electrode 125 may be formed in a pattern of a mesh structure, and may be formed on the first electrode 123 between the second electrodes 125 of the mesh structure.
  • the gas supply passage (gas hole) h formed in the substrate 121 may also be formed through a semiconductor manufacturing process.
  • the dielectric 127 is formed to cover the first and second electrodes 123 and 125, and is formed to have a predetermined thickness so as to electrically cut off the outside and discharge the plasma effectively.
  • the secondary electron generation layer 128 and the hydration prevention layer 129 may be sequentially stacked on the outer side of the dielectric 127 to be further formed.
  • the secondary electron generation layer 128 and the anti-hydration layer 129 may be formed by a semiconductor manufacturing process such as the dielectric 127 and the electrodes 123 and 125.
  • the secondary electron generation layer 128 may serve to regenerate more charge from the generated plasma.
  • the secondary electron generation layer 128 may be selectively applied.
  • the plasma generating unit 120 having such a configuration can be formed as a surface discharge structure with a desired area without being restricted by the area, and electrode formation can be made by semiconductor manufacturing technology (potolithography technology) to make a fine electrode structure. Thus, high density plasma can be generated even at low power.
  • the plasma generator 120 of the above configuration supplies gas through the gas supply path 111 while applying an alternating voltage to the first and second electrodes 123 and 125, the first and second electrodes 123 and 125 are disposed between the first and second electrodes 123 and 125. In the plasma is generated.
  • the interval between the first and second electrodes 123 and 125 is approximately 100 to 400 ⁇ m
  • the discharge voltage is set to 1 kV or less
  • the discharge current is set to have a characteristic of 10 mA or less.
  • the plasma guide unit 130 guides the plasma energy generated by the plasma generating unit 120 toward the uterine external cervix (extocervix) 10, which is a target human body to be treated.
  • the plasma guide unit 130 includes an outer tube guide member 131 for guiding the generated plasma connected to the distal end of the device housing 110 to the uterine cervix 10 of the cervix.
  • the outer diameter tube guide member 131 is a coupling portion 131a coupled to the front end of the device housing 110 and an expansion rib 131b extending to the coupling portion 131a to surround the outer diameter tube of the cervix. It is provided.
  • the coupling part 131a has a cylindrical structure and may be coupled to an outer edge of the front end of the device housing 110.
  • the expansion rib 131b is integrally formed with the coupling portion 131a and gradually extends in diameter from the coupling portion 131a.
  • the expansion rib 131b having such a configuration may be effectively guided so that the plasma energy generated by the plasma generator 120 may be concentrated on the uterine cervix 10 by wrapping and collecting the uterine outer tube 10. Therefore, cancer cells of the uterine cervix can be effectively killed and treated.
  • the plasma treatment apparatus 100 ′ has plasma energy as an endocervical cannal 20 as the plasma guide unit 130 ′. It is characterized by having an inner diameter guide member 133 having a structure capable of guiding to be concentrated.
  • the inner diameter guide member 133 has a coupling portion 133a coupled to the front end of the device housing 110 and a connection guide portion 133b extending in a funnel shape from the coupling portion 133a and gradually decreasing in diameter. ) And a nozzle guide portion 133c extending in a tubular shape from the connection guide portion 133b.
  • the coupling portion 133a is coupled to the outer side of the front end of the device housing 110, preferably may be detachably coupled.
  • the connection guide portion 133b is integrally extended at a predetermined distance, and the diameter is gradually reduced to extend in a funnel shape.
  • the nozzle guide part 133c extends in the tubular shape of the same diameter at the edge part of the connection guide part 133b. The nozzle guide portion 133c having such a configuration is inserted into the endometrial canal so that plasma energy is concentrated in the uterine canal 20, thereby effectively killing and treating cancer cells on the endometrial canal 20 side.
  • the outer diameter guide member 131 and the inner diameter guide member 133 described above may be integrally formed at the front end of the device housing 110, it may have a structure that can be replaced by a screw fastening method. Therefore, the outer diameter guide member 131 and the inner diameter guide member 133 may be selectively employed according to the treatment area.
  • the plasma treatment apparatus 200 for cervical treatment may be installed in the device housing 201 and the device housing 201 to treat the uterine cervix.
  • a plasma generating module 210 and a second plasma generating module 220 for treating the endometrial canal are provided.
  • the first plasma generating module 210 is installed to generate a plasma in a constant region of the front end of the device housing 201 and the gas supply path 211 for supplying gas toward the front end of the device housing 201
  • the first plasma generating unit 213 is provided.
  • the cylindrical durable structure 215 extends to the first plasma generating unit 213 inside the device housing 201.
  • the internal structure 215 may include a quartz tube and may further include an insulation pipe formed of an insulating material. An electrode or an electric wire cable capable of supplying power to the first plasma generator 213 through the inside of the insulation pipe may be installed.
  • the gas supply path 211 is provided through which gas is supplied between the internal structure 215 and the device housing 201.
  • the first plasma generating unit 213 is installed at the front end of the device housing 201, and is installed to generate plasma at the outer portion except the center portion.
  • the first plasma generator 213 may have the same configuration as that of the plasma generator 120 described above with reference to FIGS. 2 and 3. However, since the second plasma generating module 220 is installed at the central portion of the front end of the device housing 201, the first plasma generating unit 213 is disposed around the center of the second plasma generating module 220. Is installed.
  • the plasma generated by the first plasma generator 213 is used to treat the uterine cervix 10.
  • the second plasma generation module 220 is installed inside the internal structure 215, and preferably, a so-called plasma jet for discharging the atmospheric plasma in a jet manner.
  • a plasma jet can generate atmospheric pressure intensively in a specific portion, and thus, by focusing and discharging the plasma toward the endometrial canal 20, it can be effective in killing cancer cells of the endometrial canal 20.
  • the second plasma generation module 220 may have a configuration of a known plasma jet, and is installed at a central portion of the first plasma generation module 210 to maintain an insulation state with the first plasma generation module 210.
  • the illustrated second plasma generation module 220 may have a configuration in which an external ground electrode 222 and an internal electrode 223 are installed with a quartz tube 221 interposed therebetween.
  • plasma is generated by a gap with the external ground electrode 222 at your portion 223a at the other end of the internal electrode 223.
  • This configuration is formed in a thin tubular shape, and is installed inside the internal structure 215 inside the device housing 201. Therefore, the plasma jet generated at the tip of the second plasma generating module 220 may be concentrated at the center of the tip of the device housing 201 to be concentrated at the inlet side of the endometrial tube 20.
  • the plasma generated by the first plasma generator 210 is concentrated on the uterine cervix 20, and used to kill cancer cells of the ectopic tube 10.
  • a so-called hybrid plasma treatment apparatus in which DBD (Dielectric Barrier Discharge) plasma and plasma jet are mixed is used.
  • DBD Dielectric Barrier Discharge
  • a device installed in the device housing 201 and the device housing 201 is provided.
  • First and second plasma generation module 210, 220 and the plasma guide unit 230 is provided.
  • first and second plasma generation module 210, 220 has been described in detail with reference to Figures 7 and 8, further description thereof will be omitted.
  • the plasma guide unit 230 includes an outer diameter guide member 231 and an inner diameter guide member 233.
  • the outer diameter guide member 231 serves to guide the plasma energy generated by the first plasma generating module 210 toward the uterine outer tube 10.
  • the outer diameter guide member 213 may have the same configuration as the outer diameter guide member 131 described above with reference to FIG. 1. That is, the outer tube guide member 231 is connected to the outer edge of the front end of the device housing 201, and extends outward to support the outer uterine tube 10 so as to concentrate the plasma on the uterine tube 10. Play a role.
  • the inner diameter guide member 233 is installed at a boundary between the first plasma generating module 210 and the second plasma generating module 220 and has a nozzle shape having a predetermined diameter.
  • the inner diameter guide member 233 has a diameter enough to enter the inner diameter tube so that the plasma jet is concentrated to the inside of the uterine inner tube 20, it is preferably formed to a predetermined length.
  • the inner diameter guide member 233 may be formed of a dielectric, and may be integrally formed by being connected to the dielectric of the first plasma generating module 210.
  • the plasma generated by each of the endometrial tube 10 and the endometrial tube 20 acts on each site. It can effectively treat precancerous lesions.
  • the inner tube guide member 233 passes through the endometrial tube 20 and enters the uterus to directly reach the inner precancerous lesion so that the cancer cells can be effectively killed and treated.

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Abstract

L'invention concerne un dispositif de thérapie par plasma pour le traitement du cancer du col de l'utérus, comprenant : un boîtier de dispositif en forme de sonde qui peut être inséré dans un spéculum vaginal afin de traiter le col de l'utérus; une unité de génération de plasma pour générer de l'énergie de plasma et émettre le plasma généré vers une extrémité du boîtier de dispositif; et une unité de guidage de plasma installée à l'extrémité du boîtier de dispositif pour guider le plasma, généré par l'unité de génération de plasma, vers le col de l'utérus de façon à focaliser le plasma sur le col de l'utérus.
PCT/KR2018/009390 2018-03-16 2018-08-16 Dispositif de thérapie par plasma pour le traitement du cancer du col de l'utérus Ceased WO2019177211A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2018-0030916 2018-03-16
KR20180030916 2018-03-16

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WO2019177211A1 true WO2019177211A1 (fr) 2019-09-19

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Cited By (1)

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KR20170125447A (ko) * 2016-05-04 2017-11-15 동아대학교 산학협력단 저온 플라즈마 분사 장치를 이용한 암세포의 선택적 세포사멸 방법 및 이를 이용한 종양 치료 방법

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Publication number Priority date Publication date Assignee Title
EP4342520A4 (fr) * 2021-06-16 2025-06-18 IBMsol Co., Ltd. Dispositif de génération de plasma pour col de l'utérus

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