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WO2019159914A1 - Accélérateur de dissolution du calcium - Google Patents

Accélérateur de dissolution du calcium Download PDF

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Publication number
WO2019159914A1
WO2019159914A1 PCT/JP2019/004926 JP2019004926W WO2019159914A1 WO 2019159914 A1 WO2019159914 A1 WO 2019159914A1 JP 2019004926 W JP2019004926 W JP 2019004926W WO 2019159914 A1 WO2019159914 A1 WO 2019159914A1
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Prior art keywords
calcium
phosphorylated
oligosaccharide
maltodextrin
dissolution
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Ceased
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PCT/JP2019/004926
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English (en)
Japanese (ja)
Inventor
卓朗 柏村
傑 石川
ゆう子 須田
美和 砂田
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Oji Holdings Corp
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Oji Holdings Corp
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Definitions

  • the present invention relates to a calcium dissolution promoter.
  • Calcium-enriched foods and calcium-enriched feeds are required not only to adjust the calcium content but also to make calcium readily available in the intestine.
  • calcium In order for calcium to be absorbed in the human intestine, calcium must be dissolved as ions in water at a minimum. Therefore, making a product in which calcium is easily dissolved in water is a prerequisite for making a fortified food or a fortified feed with high calcium absorption.
  • Patent Document 1 discloses a calcium-enriched liquid sugar, which describes that casein phosphopeptides and phosphorylated sugars improve the solubility of calcium under neutral conditions and in the presence of phosphate. .
  • An object of the present invention is to provide a calcium dissolution accelerator, and more specifically, to provide a calcium dissolution accelerator that can be added to foods, feeds, fertilizers, and the like.
  • Patent Document 1 discloses that soluble calcium in a diluted liquid of calcium-enriched liquid sugar containing casein phosphopeptide and phosphorylated maltodextrin hardly forms a precipitate of calcium phosphate even when phosphate is added to the diluted liquid. The results shown are specifically disclosed. However, in Patent Document 1, the difference in soluble calcium concentration between water not containing phosphate and water containing phosphate is only determined as calcium solubility, and the total amount of calcium dissolved in water is improved. There is no disclosure regarding the calcium dissolution promoting effect.
  • the present inventors confirmed the presence or absence of a calcium dissolution promoting action for the casein phosphopeptide and various phosphorylated sugars described in Patent Document 1, and the phosphorylated oligosaccharide or phosphorylated maltodextrin salt is remarkable. It has been found that it has a calcium dissolution promoting effect. Based on this finding, the present inventors have further studied and completed the present invention. Specifically, the present invention provides the following [1] to [11].
  • a calcium dissolution promoter comprising as an active ingredient at least one selected from the group consisting of a phosphorylated oligosaccharide metal salt and a phosphorylated maltodextrin metal salt.
  • the calcium dissolution promoter according to [1] comprising a phosphorylated oligosaccharide metal salt as an active ingredient.
  • the calcium dissolution promoter according to [2], wherein the phosphorylated oligosaccharide metal salt is phosphorylated oligosaccharide sodium salt or phosphorylated oligosaccharide calcium salt.
  • a phosphorylated maltodextrin metal salt is included as an active ingredient, The calcium dissolution promoter according to [1], wherein the phosphorylated maltodextrin metal salt is phosphorylated maltodextrin sodium salt.
  • a calcium reinforcing composition comprising the calcium dissolution promoter according to any one of [1] to [5] and calcium carbonate or calcium monocarboxylate.
  • the calcium reinforcing composition according to [6] wherein the calcium monocarboxylate is calcium gluconate or calcium lactate.
  • the calcium solubility promoter as described in [2] whose said phosphorylated oligosaccharide metal salt is phosphorylated oligosaccharide sodium salt is provided.
  • At least one calcium solubility enhancer selected from the group consisting of phosphorylated oligosaccharide metal salts and phosphorylated maltodextrin metal salts
  • Use for the production of at least one calcium dissolution promoter selected from the group consisting of phosphorylated oligosaccharide metal salts and phosphorylated maltodextrin metal salts
  • Phosphorylated oligosaccharide metal salt or phosphorylated maltodextrin metal salt for use as a calcium dissolution promoter
  • a method for promoting calcium dissolution in water comprising phosphorylated oligosaccharide metal salt and phosphorylated maltodextrin metal salt
  • a method comprising adding at least one effective amount selected from the group to water.
  • the present invention provides a calcium dissolution promoter that can be added to food, feed, fertilizer, or the like.
  • FIG. 5 is a graph showing the difference in dissolution promoting effect between phosphorylated oligosaccharide calcium (POs-Ca), phosphorylated oligosaccharide sodium (POs-Na), phosphorylated maltodextrin sodium (PMD), and phosphorylated starch (PST).
  • calcium dissolution promotion means promoting the dissolution of calcium (Ca) in a solvent.
  • the dissolution of calcium means that a part of the calcium salt contained in the calcium supply source is dissolved in the solvent, and the calcium salt and the calcium ion are in equilibrium in the solvent. That is, the calcium dissolution promotion means promoting the dissolution of the calcium source into the solvent or improving the solubility of the divalent calcium ion (Ca 2+ ) in the solvent.
  • the solvent is not particularly limited as long as it can dissolve the calcium salt, and is preferably water, a water-soluble organic solvent or a mixture thereof, more preferably water or a mixture of water and a water-soluble organic solvent.
  • the water-soluble organic solvent include alcohols such as ethanol.
  • the solvent is preferably one that does not substantially contain a component that inhibits dissolution of the calcium salt in the solvent.
  • substantially free of a component that inhibits dissolution of a calcium salt in a solvent means that the inhibitory component is not included to such an extent that the dissolution of the calcium salt in the solvent is affected.
  • An example of such an inhibitory component is phosphoric acid.
  • Calcium dissolution promotion is preferably acceleration of dissolution of a calcium salt in a solvent particularly near neutrality (specifically, pH 5 to 8, preferably pH 7).
  • Whether or not the object has a calcium dissolution accelerating action depends on the concentration of calcium ions in the aqueous solution when a calcium source is added to the aqueous solution containing the object and saturated as shown in the examples below. This can be confirmed by confirming whether or not the concentration of calcium ions in the solution is improved when a calcium supply source is added to water to which water is not added and is saturated. That is, it can be determined that an object that improves the concentration of calcium ions that can be dissolved when added to water can be used as an active ingredient of a calcium dissolution accelerator.
  • the calcium dissolution promoter of the present invention contains a phosphorylated oligosaccharide metal salt or a phosphorylated maltodextrin metal salt as an active ingredient.
  • a polysaccharide having an average polymerization degree of 10 or less is referred to as an oligosaccharide, and a polysaccharide having an average polymerization degree exceeding 10 is referred to as maltodextrin.
  • the average degree of polymerization can be calculated from approximate values obtained by measuring total sugars (for example, the subtraction method, phenol sulfate method) and reducing sugars (for example, the Lane-Einon method, the Somogy Nelson method), respectively.
  • “include as an active ingredient” means that it is contained as a main active ingredient, and means that it is contained to the extent that a desired effect is obtained.
  • Both phosphorylated oligosaccharide metal salt and phosphorylated maltodextrin metal salt are polysaccharides produced from plants. Therefore, it is highly safe as an additive to food and feed. Moreover, it can be used as a feed ingredient for producers who avoid the use of animal-derived substances due to the problem of BSE (Bovine Spongiform Encephalopathy). Furthermore, it can also be used for products for consumers (for example, animal-free products and halal products) that avoid the use of substances derived from animals such as cattle and pigs due to religious ethics.
  • BSE Bovine Spongiform Encephalopathy
  • the calcium dissolution promoter of the present invention may contain only one metal salt selected from the group consisting of a phosphorylated oligosaccharide metal salt or a phosphorylated maltodextrin metal salt, or two or more metal salts. May be.
  • a phosphorylated oligosaccharide metal salt and a phosphorylated maltodextrin metal salt may be included.
  • the calcium dissolution promoter of the present invention may consist of only phosphorylated oligosaccharide metal salt or phosphorylated maltodextrin metal salt, and contains components other than phosphorylated oligosaccharide metal salt or phosphorylated maltodextrin metal salt. Also good.
  • the calcium dissolution accelerator of the present invention may be solid or liquid (liquid).
  • the calcium dissolution accelerator of the present invention may be a solution dissolved as it is in a solvent.
  • the calcium dissolution promoter of the present invention may be a solution obtained by dissolving a phosphorylated oligosaccharide metal salt or a phosphorylated maltodextrin metal salt in a solvent and then concentrating the calcium phosphate.
  • the calcium dissolution promoter of the present invention may be in the form of powder, granules or cubes.
  • an aqueous solution containing a phosphorylated oligosaccharide metal salt or a phosphorylated maltodextrin metal salt and optionally other components may be concentrated and dried to obtain a powder.
  • the calcium dissolution promoter of the present invention is preferably transported as a solid such as a powder. This is because the cost during transportation can be reduced. In this case, it can be dissolved in a solvent as needed during use.
  • the calcium dissolution accelerator of the present invention is a liquid
  • the calcium dissolution accelerator of the present invention is preferably used as a solution containing an active ingredient at an appropriate concentration.
  • the lower limit of the concentration of the active ingredient in the solution is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, Especially preferably, it is 0.5 mass% or more, Most preferably, it is 1 mass% or more, Most preferably, it is 2 mass% or more.
  • the upper limit of the concentration of the active ingredient in the solution is not particularly limited as long as it can be dissolved, and is preferably 50% by mass or less from the viewpoint of cost.
  • the concentration of the active ingredient in the solution is 0.01 to 50% by mass, more preferably 0.1 to 30% by mass, and still more preferably 0.5 to 20% by mass. Particularly preferred is 1 to 10% by mass, and most preferred is 1 to 5% by mass.
  • a phosphorylated oligosaccharide metal salt is a compound in which a partially phosphorylated oligosaccharide is bound to a metal.
  • the number of monosaccharides constituting the oligosaccharide in the phosphorylated oligosaccharide metal salt used in the calcium dissolution promoter of the present invention is preferably 2 or more and 10 or less, and preferably 2 or more and 8 or less. More preferably, it is 2 or more and 5 or less.
  • the amount of the phosphate group introduced into the oligosaccharide is preferably 1 or more and 10 or less, more preferably 1 or more and 5 or less per molecule of phosphorylated oligosaccharide.
  • the molecular weight of the phosphorylated oligosaccharide is preferably 400 or more.
  • the molecular weight of the phosphorylated oligosaccharide is preferably 3000 or less, more preferably 2000 or less, and even more preferably 1000 or less.
  • the molecular weight of the phosphorylated oligosaccharide is 400 or more and 3000 or less, more preferably 400 or more and 1000 or less.
  • the molecular weight of the oligosaccharide refers to the weight average molecular weight.
  • a metal ion having a positive charge forms a salt with the phosphate group.
  • the metal include at least one selected from sodium, potassium, calcium, magnesium, iron, zinc, copper, vanadium, manganese, cobalt, nickel, aluminum, selenium, and molybdenum.
  • the metal is preferably at least one selected from sodium, potassium, calcium, magnesium, iron, copper, nickel, and aluminum.
  • at least one selected from sodium, potassium, calcium, magnesium, iron and zinc is preferable, sodium or calcium is more preferable, and sodium is more preferable.
  • the phosphorylated oligosaccharide metal salt is preferably a salt containing a single metal, but may be a complex salt containing two or more metals.
  • the number of metal ions contained in the phosphorylated oligosaccharide metal salt is not particularly limited, and metal ions may be bonded to all of the phosphate groups present in the phosphorylated oligosaccharide, or only a part of the metal ions may be present. May be combined. For example, only one metal ion may be present in one molecule of phosphorylated oligosaccharide, two may be present, or three or more may be present.
  • the upper limit of metal ions present in one molecule of phosphorylated oligosaccharide can be, for example, 10 or less. 1 to 10 metal ions are preferably present in one molecule of phosphorylated oligosaccharide, and more preferably 1 to 5 metal ions are more preferably present.
  • the phosphorylated oligosaccharide metal salt can be produced by decomposing a saccharide such as a known starch having a phosphate group, or by producing an oligosaccharide obtained by decomposing the saccharide.
  • a saccharide such as a known starch having a phosphate group
  • Glucan is preferably used as a saccharide that is a raw material for producing a phosphorylated oligosaccharide metal salt.
  • starch having a lot of phosphate groups bound thereto, such as potato crude starch is preferable.
  • modified starch is also preferably used.
  • starch having a lot of phosphate groups bound thereto such as potato crude starch. This is because the number of steps in production is small, and coloring that tends to occur in the step of phosphorylating starch can be prevented.
  • a phosphorylated oligosaccharide metal salt can be obtained by decomposing a starch having a phosphate group or a modified starch.
  • starch degrading enzyme glycosyltransferase, ⁇ -glucosidase and the like can be used, and these may be used alone or in combination.
  • ⁇ -glucosidase it is preferably used in combination with other enzymes.
  • the amylolytic enzyme is preferably at least one selected from the group consisting of ⁇ -amylase, ⁇ -amylase, glucoamylase, isoamylase, pullulanase, and neopullulanase.
  • the glycosyltransferase is preferably a cyclodextrin glucanotransferase.
  • a separation and purification step as needed after the step of decomposing the starch having a phosphate group or the modified starch.
  • insoluble substances such as proteins are removed, or oligosaccharides having a phosphate group introduced are separated from oligosaccharides having no phosphate group.
  • the type of anion exchange resin is not particularly limited, but Chitopearl BCW2501 type (Fuji Boseki), Amberlite IRA type (Organo), DEAE-cellulose (Whatman), DEAE-Sephadex, QAE-Sephadex (Pharmacia), QAE-cellulose (BioRad) and the like are preferably used.
  • a metal salt is allowed to act on the phosphorylated oligosaccharide.
  • phosphorylated oligosaccharide sodium salt can be obtained by acting a water-soluble sodium salt.
  • the phosphorylated maltodextrin (hereinafter sometimes referred to as PMD) in the present invention is a phosphorylated saccharide in which at least one phosphate group is bonded to a maltodextrin having an average degree of polymerization exceeding 10.
  • the number of monosaccharides constituting maltodextrin in the phosphorylated maltodextrin metal salt used in the calcium dissolution promoter of the present invention is preferably 11 or more, more preferably 11 or more and 30 or less, More preferably, it is 11 or more and 20 or less.
  • the amount of phosphate group introduced into maltodextrin is preferably 1 or more and 30 or less, more preferably 1 or more and 10 or less, and more preferably 1 or more and 5 or less per molecule of phosphorylated maltodextrin. It is more preferable that
  • the molecular weight of phosphorylated maltodextrin is preferably 2000 or more.
  • the molecular weight of phosphorylated maltodextrin is 2000 or more and 15000 or less.
  • the molecular weight of phosphorylated maltodextrin refers to the weight average molecular weight.
  • metal ions having a positive charge form a salt with the phosphate group.
  • the metal include at least one selected from sodium, potassium, calcium, magnesium, iron, zinc, copper, vanadium, manganese, cobalt, nickel, aluminum, selenium, and molybdenum.
  • the metal is preferably at least one selected from sodium, potassium, calcium, magnesium, iron, copper, nickel, and aluminum.
  • at least one selected from sodium, potassium, calcium, magnesium, iron and zinc is preferable, sodium or calcium is more preferable, and sodium is more preferable.
  • the phosphorylated oligosaccharide metal salt is preferably a salt containing a single metal, but may be a complex salt containing two or more metals.
  • the number of metal ions contained in the phosphorylated maltodextrin metal salt is not particularly limited, and metal ions may be bonded to all of the phosphate groups present in the phosphorylated maltodextrin, or only part of the metal ions may be present. May be combined. For example, only one metal ion may be present in one molecule of phosphorylated maltodextrin, two may be present, or three or more may be present.
  • the upper limit of metal ions present in one molecule of phosphorylated maltodextrin can be, for example, 10 or less. For example, 1 to 10 metal ions may be present in one molecule of phosphorylated maltodextrin.
  • Phosphorylated maltodextrin can be produced by the same production method as that for the phosphorylated oligosaccharide metal salt.
  • As a manufacturing method of phosphorylated maltodextrin it is preferable to decompose and manufacture the phosphorylated starch which phosphorylated the well-known starch.
  • As the raw material starch it is preferable to use starch originating from corn, sweet potato, tapioca, wheat, barley, rice or the like.
  • Phosphorylation can be performed using, for example, a phosphoric acid solution containing sodium dihydrogen phosphate and disodium hydrogen phosphate.
  • the degradation of phosphorylated starch can be carried out using any of the starch degrading enzymes described above in the production of phosphorylated oligosaccharide metal salts, and is preferably carried out with ⁇ -amylase.
  • a purified phosphorylated maltodextrin can be obtained by separating and purifying the resulting degradation product. Separation and purification can be performed by one or a combination of two or more purifications using ion exchange chromatography, filtration membranes, and the like.
  • a phosphorylated maltodextrin metal salt can be obtained by allowing a metal salt to act on the obtained phosphorylated maltodextrin.
  • phosphorylated maltodextrin sodium salt can be obtained by allowing a water-soluble sodium salt to act.
  • the method described in WO2005 / 003753 can be referred to.
  • the calcium supply source whose dissolution is promoted by the calcium dissolution promoter of the present invention may be metallic calcium or a calcium salt compound, but is preferably a calcium salt compound.
  • Examples of calcium salt compounds include calcium halides such as calcium chloride, amino acid calciums such as calcium glutamate, calcium hydrogen phosphate, calcium hydroxide, calcium carbonate, and calcium carboxylate. Of these, calcium carbonate or calcium carboxylate is preferable, and calcium carbonate or calcium monocarboxylate is more preferable. As calcium monocarboxylate, calcium lactate and calcium gluconate are preferable.
  • calcium carbonate, calcium lactate, and calcium gluconate have lower solubility in water than calcium chloride, but the solubility can be increased by coexisting the calcium dissolution promoter of the present invention. It can be greatly improved.
  • the counter ion of the calcium ion of the calcium salt compound which is a calcium supply source has a low chelating action on calcium.
  • phosphorylated oligosaccharide metal salts and phosphorylated maltodextrin metal salts each dissolve and chelate calcium ions at the phosphate group moiety to promote calcium dissolution. It is thought that there is. Therefore, when the counter ion of the calcium salt compound that is a calcium supply source has a chelating action, it is considered that the effect of promoting dissolution by adding a phosphorylated oligosaccharide metal salt or a phosphorylated maltodextrin metal salt is reduced.
  • the molecular weight of the calcium salt compound serving as the calcium supply source is not particularly limited, but is preferably 90 or more, preferably 1200 or less, more preferably 1000 or less, further preferably 800 or less, and particularly preferably 500 or less.
  • the calcium dissolution promoter of the present invention can be used as an additive for compositions provided as food (including beverages), feed, fertilizer, pharmaceuticals, medicines, and cosmetics.
  • the food include miso soup and health food.
  • the feed include ruminant feed, chicken egg feed, and animal growth promoting feed (agent).
  • the calcium dissolution promoter of the present invention can be added to the composition together with the calcium supply source, the calcium in the calcium supply source can be easily dissolved or dissolved. Therefore, the composition containing the calcium dissolution promoter of the present invention together with a calcium supply source can be provided as, for example, a calcium-enriched food or a calcium-enriched feed.
  • the calcium dissolution promoter of the present invention is useful as an additive for a calcium reinforcing composition containing calcium ions at a high concentration.
  • the quantitative ratio of the calcium dissolution accelerator and the calcium supply source is not particularly limited.
  • the mass of the phosphorylated oligosaccharide metal salt is 0.1 mass% to 10 mass% of the mass of calcium ions derived from the calcium source.
  • the content is 1.0% by mass to 5.0% by mass.
  • the mass of the phosphorylated maltodextrin metal salt is 0.1% by mass to 10% by mass of the mass of calcium ions derived from the calcium supply source. It is preferably 1.0% by mass to 10% by mass, more preferably 1.0% by mass to 5.0% by mass.
  • compositions containing a calcium dissolution promoter and a calcium source include the following: A composition comprising sodium phosphorylated oligosaccharide and calcium gluconate; A composition comprising phosphorylated oligosaccharide calcium and calcium gluconate; A composition comprising phosphorylated oligosaccharide sodium and calcium carbonate; A composition comprising phosphorylated oligosaccharide calcium and calcium carbonate; A composition comprising phosphorylated oligosaccharide calcium and calcium lactate; and a composition comprising phosphorylated maltodextrin sodium and calcium gluconate.
  • calcium In the calcium determination in the examples, calculation was performed assuming that 1 mL of 0.01 M EDTA was 0.4008 mg of Ca. In Examples, “%” indicates “% by mass”. In Examples, “calcium” may be abbreviated as “Ca”, and “sodium” may be abbreviated as “Na”. For example, “Ca gluconate” means “calcium gluconate”, and “phosphorylated oligosaccharide Na” means “phosphorylated oligosaccharide sodium”.
  • phosphorylated oligosaccharide Ca was obtained from Oji Cornstarch Co., Ltd.
  • Phosphorylated oligosaccharide Na was prepared by dissolving phosphorylated oligosaccharide Ca in water, removing calcium ions with a cation exchange resin, and then neutralizing with sodium hydroxide.
  • Phosphorylated maltodextrin Na was prepared by the following procedure. Casein phosphopeptide manufactured by Wako Pure Chemical Industries, Ltd. was used as the casein phosphopeptide.
  • 500 g of the obtained phosphoric acid mixed starch was uniformly spread on a 320 mesh wire mesh so as to have an average thickness of 5 mm, and the wire mesh was mounted on a shelf dryer and dried at a hot air temperature of 95 ° C. for 1 hour. . Subsequently, the hot air temperature was raised to 175 ° C. and held for 2 hours for phosphorylation. The heater was stopped to cool air, and the phosphorylated starch was recovered after the product temperature reached 50 ° C. or lower.
  • the phosphorylated starch thus obtained had a bound phosphorus content of 2.8% by mass and a phosphorylation rate of 80%.
  • Powdered activated carbon (PM-KI, PM-SX mixed 1: 1) was added to the deactivation liquid at 10% of the mass of the solid content, held at 60 ° C for 2 hours, and then a ceramic filter (0.2 ⁇ m) The product was decolored and impurities were removed by filtration at.
  • the activated carbon treatment solution was treated with an NF membrane (NTR-7450) to desalinate and remove low-molecular neutral sugars.
  • the NF membrane treatment solution was adjusted to pH 6.5 with sodium hydroxide and then filtered through a sanitary t filter (0.45 ⁇ m).
  • the sterilization treatment liquid was pulverized with a spray dryer under conditions of an inlet hot air temperature of 200 ° C. and an outlet hot air temperature of 100 ° C. to obtain phosphorylated maltodextrin Na.
  • Casein phosphopeptide 2 g was dissolved in water and made up to 100 mL. The obtained solution was subjected to chelate titration with a 0.05M EDTA solution, and the amount of Ca was calculated.
  • FIG. 1 shows changes in the calcium dissolution rate when the pH is changed.
  • POs-Na represents phosphorylated oligosaccharide Na
  • Ctrl represents an example in which the calcium dissolution rate was similarly determined without adding phosphorylated oligosaccharide Na. From FIG. 1, it can be seen that at pH 5-7, the higher the pH, the higher the Ca dissolution promoting effect.
  • FIG. 2 shows the change in the calcium dissolution rate due to the test substance.
  • POs-Na represents phosphorylated oligosaccharide Na
  • POs-Ca represents phosphorylated oligosaccharide Ca
  • PMD represents phosphorylated maltodextrin Na
  • PST represents phosphorylated starch
  • Ctrl represents any test substance. The example which calculated
  • the Ca dissolution promoting effect was obtained in phosphorylated oligosaccharide Na, phosphorylated maltodextrin Na, and phosphorylated oligosaccharide Ca.
  • the calcium solubility decreased with phosphorylated starch.
  • the Ca dissolution promoting effect is higher for phosphorylated oligosaccharide salts than phosphorylated maltodextrin salts for the same Na salt, and Na salts for Ca phosphorylated oligosaccharide salts are higher for phosphorylated oligosaccharide salts. I understand.

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un accélérateur de dissolution du calcium qui peut être ajouté à des aliments, à des aliments pour animaux ou à des engrais, etc., l'accélérateur de dissolution du calcium contenant en tant que principe actif au moins un élément choisi dans le groupe constitué par un sel métallique d'oligosaccharide phosphorylé et un sel métallique de maltodextrine phosphorylé. La présente invention concerne également une composition fortifiante de calcium comprenant ledit accélérateur de dissolution du calcium, et un carbonate de calcium ou un monocarboxylate de calcium.
PCT/JP2019/004926 2018-02-14 2019-02-13 Accélérateur de dissolution du calcium Ceased WO2019159914A1 (fr)

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JP2018023767A JP2019137645A (ja) 2018-02-14 2018-02-14 カルシウム溶解促進剤
JP2018-023767 2018-02-14

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CN114280223B (zh) * 2021-12-22 2024-05-03 安徽华好阳光乳业有限公司 一种巴氏奶中钙的测定方法

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