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WO2019142757A1 - Auxiliary tool and method for inserting endotracheal tube for mouse using same - Google Patents

Auxiliary tool and method for inserting endotracheal tube for mouse using same Download PDF

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Publication number
WO2019142757A1
WO2019142757A1 PCT/JP2019/000843 JP2019000843W WO2019142757A1 WO 2019142757 A1 WO2019142757 A1 WO 2019142757A1 JP 2019000843 W JP2019000843 W JP 2019000843W WO 2019142757 A1 WO2019142757 A1 WO 2019142757A1
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WO
WIPO (PCT)
Prior art keywords
endotracheal tube
mouse
opening
shaft member
auxiliary tool
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2019/000843
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French (fr)
Japanese (ja)
Inventor
卓 西野
久予 神
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiba University NUC
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Chiba University NUC
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Publication date
Application filed by Chiba University NUC filed Critical Chiba University NUC
Priority to JP2019566454A priority Critical patent/JP7309199B2/en
Publication of WO2019142757A1 publication Critical patent/WO2019142757A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04Tracheal tubes

Definitions

  • the present invention relates to an aid and a method of intubating a mouse endotracheal tube using the same.
  • the position of the larynx can be accurately grasped using the image taken by a camera attached to the endoscope, and the endotracheal tube is It is excellent in that it can be intubated in the tube.
  • Kenjiro KONNO et al., “New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia”, J. Vet. Med. Sci, 2014, 76 (6), p. 863-868 Crotaz IR, "Initial feasibility investigation of the v-gel airway: an anatomically designed" "supprestive airway device for use in companion animal veterinary anaesthesia", veterinary Anaesthesia and Analgesia, 2010, 37, p. 579-580
  • Non-Patent Document 2 a device obtained by modifying the supraglottic airway securing device (v-gel) (see, for example, Non-Patent Document 2) applicable to laryngeal masks applicable to animals such as rabbits. It is also conceivable to use it to intubate an endotracheal tube into the airway of the mouse.
  • v-gel supraglottic airway securing device
  • the above-mentioned device originally merely covers the larynx and does not intubate the endotracheal tube, and additionally, the pharyngeal shape of the mouse is very small compared to a rabbit or the like, and the shape is not a mere similar shape.
  • the mere modification of the above device can not be applied to the intubation of an endotracheal tube into a mouse.
  • the mouse may be excessively stressed due to an erroneous operation or the like, and there is a possibility that the mouse may be killed by being forcibly pushed.
  • the present invention has been made based on the circumstances as described above, and its object is to make it possible to intubate the endotracheal tube of a mouse reliably, quickly and easily without using expensive equipment.
  • An aid for guiding an endotracheal tube into the trachea of a mouse via the larynx A shaft member having a through hole through which the endotracheal tube is inserted; A mask member connected to one end of the shaft member and abutting at least a part of the periphery of the laryngeal opening in the pharynx; The mask member has an opening communicating with the through hole of the shaft member, An auxiliary tool characterized in that a delivery direction of the endotracheal tube through the opening is formed at an acute angle with respect to a distal direction of the shaft member.
  • the auxiliary tool according to the above (1) wherein the mask member has a deflection unit that deflects the advancing direction of the endotracheal tube.
  • the tube according to the above (1) which is formed so as to allow the endotracheal tube to be inserted therein and communicate with the through hole of the shaft member and has a curved pipe member for deflecting the advancing direction of the endotracheal tube.
  • the tip is located in the middle of the shaft body in the axial direction of the shaft member, and includes a projecting member protruding from the outer peripheral surface of the shaft body according to any one of (1) to (3) Auxiliary equipment, (5) The auxiliary tool according to (4), wherein the projecting members are arranged to be symmetrical with respect to a virtual plane passing through the axis of the shaft member and the center of the opening.
  • the shaft member has a marker at an outer peripheral portion of a predetermined distance along the proximal end direction of the shaft member from the end of the opening in the proximal direction, any of the above (1) to (5) Auxiliaries listed in paragraph 1 or (7) Any one of the above items (1) to (6), wherein the delivery direction of the endotracheal tube through the opening is formed so as to be 4 ° or more and 30 ° or less with respect to the distal end direction of the shaft member And (8) a method of intubating an endotracheal tube for a mouse, which guides the endotracheal tube into the endotracheal space of the mouse through the larynx.
  • the “tip direction” is a direction along the axial direction of the shaft member, and is the direction of the end where the mask member is provided with respect to the end where the mask member of the shaft member is not provided.
  • proximal direction means a direction along the axial direction of the shaft member and means the direction opposite to the distal direction.
  • distal end indicates the distal end of any member or site, and “proximal” indicates the proximal end of any member or site.
  • the "predetermined distance” is defined as the length along the mouth and pharynx of the mouse and corresponds to the standard length between a specific part of the mouse body (for example, incisor teeth) and the laryngeal opening. Means the distance
  • the present invention provides an aid capable of reliably, quickly and easily intubating the endotracheal tube of the endotracheal tube without using an expensive instrument, and a method of intubating the endotracheal tube for a mouse using the same. Can be provided.
  • FIG. 5 is a schematic plan view of FIG. 4;
  • FIG. 10 is a schematic plan view showing a third embodiment of the present invention, wherein (a) to (d) show an assisting tool provided with projecting members of various shapes.
  • FIG. 1 It is a schematic side view showing a 3rd embodiment of the present invention, and (a)-(f) show the auxiliary tool provided with the projection member of various shapes, respectively. It is the schematic which shows the use condition of FIG. 1, Comprising: (a) is a state which inserted the auxiliary tool in the intraoral area, (b) is a state which pressed the mask member of the auxiliary tool to the larynx, (c) is the endotracheal region. (D) shows a state in which an endotracheal tube is inserted into the trachea.
  • the auxiliary tool is an auxiliary tool for guiding an endotracheal tube into the trachea of a mouse via the larynx, and includes a shaft body having a through hole through which the endotracheal tube is inserted. And a mask member connected to one end of the shaft member and in contact with at least a part of the periphery of the larynx opening in the pharynx, the mask member having an opening communicating with the through hole of the shaft member It is characterized in that the delivery direction of the endotracheal tube through the opening portion is formed to have an acute angle with respect to the distal direction of the shaft member.
  • the endotracheal tube applied to the auxiliary tool is a flexible tube that can be bent along the through hole of the auxiliary tool, and for example, gas such as anesthetic gas or oxygen is transmitted through the endotracheal tube. Supply air to the trachea or exhale from the trachea to the outside.
  • the outer diameter of the endotracheal tube is about 0.8 mm to 1.2 mm.
  • FIG. 1 is a schematic cross-sectional view showing a first embodiment of the present invention.
  • assistant tool 1 is roughly comprised by the shaft member 11 and the mask member 21 as shown in FIG.
  • the shaft member 11 comprises a shaft body 110.
  • the shaft member 11 may also have a marker 120.
  • the shaft main body 110 is a member having a through hole 111 through which the endotracheal tube t is inserted.
  • the shaft body 110 is formed in, for example, a substantially cylindrical shape so as to have a through hole 111 which penetrates along the direction of the axis of the shaft member 11 (the axis of the shaft body 110).
  • each part of the shaft body 110 are generally 15 mm to 20 mm in total length so that when the auxiliary tool 1 is inserted through the oral cavity of the mouse, the opening 211 of the mask member 21 described later reliably reaches the larynx opening.
  • the outer diameter is usually 3 mm to 5 mm so that it can be easily inserted into the pharynx of the mouse.
  • the inner diameter is usually 1 mm to 2 mm depending on the outer diameter of the endotracheal tube t.
  • the material constituting the shaft main body 110 is not particularly limited, but is preferably made of a flexible material from the viewpoint of being able to smoothly insert the auxiliary 1 along the pharynx, and polyester resin, salt Polyvinylated resins are more preferred, and polyester resins are even more preferred. Further, the shaft body 110 may be one in which a layer such as silicone resin is laminated on the outer periphery of a member formed using the above-mentioned material.
  • the marker 120 is a mark for grasping the position of the opening 211 of the mask member 21 in the pharynx of the mouse.
  • the marker 120 is provided on the surface of the shaft body 110 and at an outer peripheral portion of a predetermined distance L4 (see FIG. 3) along the proximal direction of the shaft member 11 from the end p of the opening 211 in the proximal direction. It is done.
  • a part or the whole circumference in the circumferential direction in the outer peripheral part is colored with a pigment or the like, and a shape such as a convex part or a recess around the part or the entire circumference in the circumferential direction in the outer peripheral part It is possible to employ one in which a typical feature portion is formed.
  • a marker 120 (see FIG. 1 and FIG. 2) colored using a pigment is illustrated on the entire circumference of the outer peripheral portion.
  • the predetermined distance L4 for example, the same value as the average length between the incisor teeth and the laryngeal opening of a standard mouse can be adopted.
  • the distance between the marker 120 and the end p of the mask portion 21 is preferably 11 mm or more and 12 mm or less, and more preferably 11.6 mm.
  • the mask member 21 is connected to one end of the shaft member 11 and abuts on at least a part of the larynx opening periphery in the pharynx. As shown in FIG. 2, the mask member 21 has an opening 211 communicating with the through hole 111 of the shaft member 11. Specifically, the mask member 21 is, for example, fixed so that the proximal end surrounds the opening of the distal end of the shaft main body 110, extends from the periphery of the opening toward the distal direction, And a through hole 212 for insertion of the endotracheal tube t in communication with the through hole 111. A lumen 301 through which the endotracheal tube t can be inserted is formed by the through hole 212 and the through hole 111 described above.
  • the surface shape around the opening 211 of the mask member 21 is preferably formed to correspond to the shape around the larynx opening in the pharynx of the mouse, whereby the mask member 21 is stably seated in the larynx opening and the trachea
  • the lumen 301 of the auxiliary tool 1 can be reliably conducted.
  • each part of the mask member 21 (see FIG. 3) are usually 2 mm to 11 mm in total length L1, 2 mm to 5 mm in maximum width L2, and 2 mm to 6 mm in maximum height L3 in consideration of the shape of the pharynx and larynx opening. is there.
  • the opening 211 of the mask member 21 usually has a total length L5 of 4 mm to 6 mm and a maximum width L6 of 1 mm to 2 mm in consideration of the shape of the larynx opening.
  • the shape of the tip end portion of the mask member 21 is preferably a curved shape (a shape in which the tip end portion of the mask member 21 is not sharp when viewed from any direction, see FIGS. 1 and 2). As described above, since the shape of the tip of the mask member 21 is a curved shape, it is possible to reduce the stimulation on the sensory receptor of the mouse accompanying the contact of the mask member 21 (the tip of the mask member 21). For example, it is possible to suppress the occurrence of respiratory disorder and the like due to reflection.
  • a resin material etc. are mentioned, for example.
  • a silicone resin and a urethane resin are preferable, and a silicone resin is more preferable, from the viewpoint of reducing the irritation due to the contact with the mucous membrane of the pharyngeal inner wall.
  • the resin material discharged by the discharge device is applied to the tip of the shaft main body 110 and room temperature or heat
  • a method of forming by curing, a method of mounting the tip of the shaft body 110 on a die (not shown), filling the resin material before curing around the opening of the shaft body 110 and thermally curing the same It can be adopted.
  • the delivery direction a2 of the endotracheal tube t through the opening 211 is such that the delivery direction a2 of the endotracheal tube t is an acute angle (delivery angle ⁇ ⁇ 90 °, see FIG. 3) with respect to the tip direction a1 of the shaft member 11. Is formed.
  • the endotracheal tube t delivered from the opening part 211 can be orient
  • the delivery direction a2 of the endotracheal tube t through the opening 211 is preferably 4 ° or more and 30 ° or less, more preferably 5 ° or more and 25 ° or less with respect to the distal end direction a1 of the shaft member 11 Preferably, it is more preferably 6 ° or more and 22 ° or less.
  • the delivery direction a2 of the endotracheal tube t can be more accurately directed to the trachea direction, and the endotracheal tube t can be more reliably intubated into the trachea of the mouse.
  • the configuration for making the delivery direction a2 of the endotracheal tube t acute is not particularly limited.
  • the mask member 21 has a deflection portion 31 that deflects the advancing direction of the endotracheal tube t. It may be done.
  • a raised portion 311 or the like formed on the inner periphery in the vicinity of the opening 211 of the mask member 21 can be employed as the deflection unit 31.
  • the deflection unit 31 may be integral with or separate from the mask member 21.
  • the auxiliary tool 1 is configured such that the advancing direction of the endotracheal tube t which has passed through the through hole 111 is the shaft member 11 by contact with the deflecting portion 31.
  • the endotracheal tube t can be intubated into the trachea of the mouse with a simple configuration.
  • the delivery direction a2 of the endotracheal tube t is a tip direction Since the endotracheal tube t can be inserted into the trachea via the larynx without entering the esophagus because it has an acute angle with respect to a1, the endotracheal tube t can be used without using an expensive instrument such as an endoscope.
  • the tube can be intubated into the trachea of the mouse quickly and easily.
  • the shaft member 11 has the marker 120, the opening 211 of the mask member 21 can be accurately aligned with the laryngeal opening of the mouse.
  • FIG. 4 is a schematic cross-sectional view showing a second embodiment of the present invention.
  • assistant tool 2 is roughly comprised by the shaft member 11, the mask member 21, and the pipe member 52, as shown in FIG.
  • the present embodiment differs from the first embodiment in that the pipe member 52 is provided.
  • symbol is attached
  • the description in the section of ⁇ Method for intubating endotracheal tube for mice> described later is also used for the mode of use of the auxiliary tool 2.
  • the pipe member 52 is a curved member which is formed so as to allow the endotracheal tube t to be inserted therein, communicates with the through hole 111 of the shaft member 11, and deflects the advancing direction of the endotracheal tube t.
  • the pipe member 52 has its proximal end inserted into the through hole 111 of the shaft body 110 and is fixed so that the outer periphery of the inserted pipe member 52 and the inner periphery of the shaft body 110 are in close contact. . Further, as shown in FIG. 5, the pipe member 52 is disposed such that the opening end surface 522 at the tip end faces the opening 211 of the mask member 21.
  • the pipe member 52 has a substantially arc-like curved shape in the middle between the distal end and the proximal end such that the delivery direction a2 of the endotracheal tube t from the opening 211 is acute at the distal direction a1. Is formed.
  • the through hole 521 of the pipe member 52 and the through hole 111 form a lumen 302 through which the endotracheal tube t can be inserted.
  • stainless steel As a material which comprises pipe member 52, stainless steel, a titanium alloy, a cobalt chromium alloy etc. are mentioned, for example. Among them, stainless steel is preferable as a material to be configured with the pipe member 52, and SUS304 is more preferable, from the viewpoint of ease of preparation.
  • the front end direction a1 of the shaft member 11 is carried out so that the advancing direction of the endotracheal tube t which passed through the inside of the through-hole 111 may follow the curve shape of the pipe member 52.
  • the endotracheal tube t can be intubated into the trachea of the mouse with a simple configuration.
  • Third Embodiment 6 and 7 are a schematic plan view and a schematic side view, respectively, showing a third embodiment of the present invention.
  • the auxiliary tool 3 (3 m1 to 3 m10) is roughly configured by the shaft member 11, the mask member 21 and the projecting member 63, as shown in FIGS.
  • the present embodiment differs from the first embodiment in that a projecting member 63 is provided.
  • symbol is attached
  • the description in the section of ⁇ Method of intubating endotracheal tube for mouse> described later is also used for the usage mode of the auxiliary tool 3.
  • the projecting member 63 is a member whose tip is located in the middle of the shaft body 110 in the axial direction of the shaft member 11 and protrudes from the outer peripheral surface of the shaft body 110.
  • a part of the projecting member 63 may be fixed to the outer periphery of the shaft body 110 using an adhesive or the like, and may be formed to extend outward of the shaft body 110.
  • the specific shape of the projecting member 63 is, for example, a triangular shape (see the projecting member 63m1 of FIG. 6A) or a rectangular shape (the projecting member 63m2 of FIG. 6B) as a shape in plan view. See the following), in a shape that changes gradually in width (see the projection member 63m3 in FIG. 6 (c)), those projecting only on one side of the shaft body 110 (see the projection member 63m4 in FIG. 6 (d)), etc.
  • a shape in a side view for example, a shape extending radially from the shaft body 110 (see the projecting members 63m5 to 63m8 in FIGS.
  • FIGS. 7A to 7D a shape circumscribing the shaft body 110 (see FIGS. 7A to 7D) 7 (e) and 7 (f) can be adopted.
  • the shape of the planar view and the shape of the side view exemplified above may be combined arbitrarily within the possible range.
  • the projecting members 63 are preferably arranged to be symmetrical with respect to an imaginary plane b passing through the axis of the shaft member 11 and the center of the opening 211 (FIGS. 6A to 6C (c). 7 (a), 7 (b) and 7 (d) to 7 (f)).
  • the maximum width of the projecting member 63 in the direction orthogonal to the axis of the shaft member 11 is preferably larger than the width of the tip of the projecting member 63 (see FIGS. 6A and 6C). .
  • the said auxiliary tool 3 can be smoothly inserted in the oral cavity of a mouse
  • the projecting member 63 is preferably formed in a flat shape (substantially flat shape) as a whole (see FIGS. 7A to 7C, and FIGS. 7E and 7F). .
  • the projecting member 63 can be made to correspond to (follow along) the flat oral cavity shape of the cross section which is the feature of the mouse, and the mask member 21 can be seated on the pharyngeal opening more stably.
  • the said auxiliary tool 3 is the said structure, it can be stably seated in the oral cavity of a mouse
  • the method of intubating a mouse endotracheal tube is a method of intubating a mouse endotracheal tube for guiding the endotracheal tube into the trachea of a mouse via the larynx, and A first step of inserting the tip of the assisting tool into the pharynx of the mouse, a second step of bringing the mask member into contact with the periphery of the laryngeal opening in the pharynx after the first step, and And a third step of intubating the endotracheal tube into the trachea of the mouse through the aid.
  • the auxiliary tool 1 is inserted into the throat m3 of the mouse m from the distal direction of the auxiliary tool 1. Specifically, as shown in FIG. 8A, after inserting the assisting tool 1 into the oral cavity m2 of the mouse m, if the assisting tool 1 has the marker 120, for example, the marker 120 is the mouse m Push the larynx m3 until the position of the incisor m1 is reached, or if the marker 120 is not provided, push the laryngeal m3 until the pressing resistance of the auxiliary 1 changes (increases), the auxiliary 1 is put in the proper position insert.
  • the second step In the second step, after performing the above-mentioned first step, as shown in FIG. 8 (b), the mask member 21 is moved in the direction of the larynx m3, and the surface of the mask member 21 is around the larynx opening m5 in the pharynx m3. Abut on. At this time, at least a part of the mask member 21 may simply be in contact with the periphery of the larynx opening m5, and it is not necessary to completely cover the periphery of the larynx opening m5.
  • the surface of the epiglottis m6 be supported such that the epiglottis m6 does not close the laryngeal opening m5 by bringing the surface of the mask member 21 into contact with the epiglottis m6. Thereby, the insertion of the endotracheal tube t described later into the trachea m7 can be performed more smoothly.
  • the endotracheal tube t is intubated into the trachea m7 of the mouse m through the auxiliary tool 1. Specifically, an endotracheal tube t is inserted from the proximal end opening 112 of the shaft member 11, and the endotracheal tube t is pushed forward in the order of the through hole 111 and the through hole 212 (see FIG. 8 (c)). The distal end of the tube t is intubated into the trachea m7 via the larynx m4 (see FIG. 8 (d)).
  • desired treatment such as supply of anesthetic gas or promotion of respiration is performed using, for example, a respirator connected to the endotracheal tube t.
  • desired treatment such as supply of anesthetic gas or promotion of respiration is performed using, for example, a respirator connected to the endotracheal tube t.
  • the endotracheal tube t and the aid 1 are sequentially pulled out of the larynx m4, the pharynx m3 and the oral cavity m2 of the mouse m.
  • the intubation method has the above configuration, when the endotracheal tube t for a mouse is intubated in the trachea m7 using the auxiliary tool 1, the delivery direction a2 of the endotracheal tube t is the distal direction a1.
  • the endotracheal tube t can be intubated to the trachea m7 through the larynx m4 without entering the esophagus m8 because it has an acute angle with respect to the The tube t can be intubated in the trachea m7 of the mouse m reliably, quickly and easily.
  • the first embodiment describes the auxiliary tool 1 having the deflecting portion 31 in the first embodiment, and the auxiliary tool 2 including the pipe member 52 in the second embodiment, the endotracheal tube through the opening 211
  • the delivery direction a2 of t is formed to be an acute angle with respect to the distal direction a1 of the shaft member 11, an aid other than the aids 1 and 2 may be used.
  • the aids 1 to 3 including the shaft member 11 having the marker 120 have been described, but the aid may not have the marker.
  • the auxiliary implement used in the intubation method of the present invention is the auxiliary tool of any aspect according to the present invention.
  • the auxiliary tool 3 can also be used.

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Abstract

The purpose of the present invention is to provide an auxiliary tool capable of inserting an endotracheal tube reliably, quickly and easily into the trachea of a mouse without using an expensive instrument, and to provide a method for inserting an endotracheal tube for a mouse using the same. An auxiliary tool 1 of the present invention comprises: a shaft member 11 having a shaft body 110 having inside thereof a through hole 111 through which an endotracheal tube t is to be inserted; and a mask member 21 that is connected to one end of the shaft member 11 and is to be abutted against at least part of the larynx opening periphery in the pharynx. The mask member 21 has an opening 211 communicating with the through hole 111 of the shaft member 11, and is formed such that a delivery direction a2 of the endotracheal tube t through the opening 211 is at an acute angle with respect to the front end direction a1 of the shaft member 11.

Description

補助具、およびこれを用いたマウス用気管内チューブの挿管方法Aid and method of intubating endotracheal tube for mice using the same

 本発明は、補助具、およびこれを用いたマウス用気管内チューブの挿管方法に関する。 The present invention relates to an aid and a method of intubating a mouse endotracheal tube using the same.

 将来的なヒトへの適用と同じような条件下にてマウスに対して各種の試験を行う際、気管内チューブを用いて麻酔用のガスなどをマウスに導入する手法がある。このような手法としては、例えば、内視鏡をマウスの咽頭に挿入しながら気管内チューブを気管内に挿管し、この気管内チューブを介して上記ガスを送気する技術が知られている(例えば、非特許文献1参照)。 When conducting various tests on mice under the same conditions as future human application, there is a method of introducing an anesthetic gas and the like into mice using an endotracheal tube. As such a method, for example, there is known a technique in which an endotracheal tube is intubated into a trachea while inserting an endoscope into the pharynx of a mouse, and the gas is supplied through the endotracheal tube ( See, for example, Non-Patent Document 1).

 このような内視鏡を用いた技術によれば、内視鏡に取り付けられたカメラによる撮影画像を用いて喉頭の位置を正確に把握することができ、上記画像を視ながら気管内チューブを気管内に挿管することができる点で優れている。 According to the technique using such an endoscope, the position of the larynx can be accurately grasped using the image taken by a camera attached to the endoscope, and the endotracheal tube is It is excellent in that it can be intubated in the tube.

Kenjiro KONNO,et al、「New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia」、J.Vet.Med.Sci、2014年、76(6)、p.863-868Kenjiro KONNO, et al., “New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia”, J. Vet. Med. Sci, 2014, 76 (6), p. 863-868 Crotaz IR、「Initial feasibility Investigation of the v-gel airway:an anatomically designed supraglottic airway device for use in companion animal veterinary anaesthesia」、veterinary Anaesthesia and Analgesia、2010年、37、p.579-580Crotaz IR, "Initial feasibility investigation of the v-gel airway: an anatomically designed" "supprestive airway device for use in companion animal veterinary anaesthesia", veterinary Anaesthesia and Analgesia, 2010, 37, p. 579-580

 しかしながら、上述したような従来の内視鏡を用いる技術では、内視鏡装置にかかる費用が高く、しかも内視鏡の操作や気管内チューブの気管内への挿管に熟練を要する。 However, in the technique using the conventional endoscope as described above, the cost for the endoscope apparatus is high, and the manipulation of the endoscope and the intubation of the endotracheal tube into the trachea require skill.

 ここで、高価な器具を用いない手法として、例えば、ウサギなどの動物に適用可能な喉頭マスク用の声門上気道確保装置(v-gel)(例えば、非特許文献2参照)を改造したものを用いてマウスの気道内に気管内チューブを挿管することも考えられる。 Here, as a method that does not use an expensive instrument, for example, a device obtained by modifying the supraglottic airway securing device (v-gel) (see, for example, Non-Patent Document 2) applicable to laryngeal masks applicable to animals such as rabbits. It is also conceivable to use it to intubate an endotracheal tube into the airway of the mouse.

 しかしながら、上記装置は本来喉頭を単に覆うものであって気管内チューブを挿管するものではなく、加えてマウスの咽頭形状はウサギなどに比べて非常に小さくかつその形状は単なる相似形ではないため、上記装置の単なる改造ではマウスへの気管内チューブの挿管に適用することができない。 However, the above-mentioned device originally merely covers the larynx and does not intubate the endotracheal tube, and additionally, the pharyngeal shape of the mouse is very small compared to a rabbit or the like, and the shape is not a mere similar shape. The mere modification of the above device can not be applied to the intubation of an endotracheal tube into a mouse.

 また、誤操作等によりマウスに過大なストレスを与えることもあり、無理に押し込むことでマウスを死に至らせる虞もある。 In addition, the mouse may be excessively stressed due to an erroneous operation or the like, and there is a possibility that the mouse may be killed by being forcibly pushed.

 本発明は、以上のような事情に基づいてなされたものであり、その目的は、高価な器具を用いることなく、気管内チューブを確実、迅速かつ容易にマウスの気管内に挿管することが可能な補助具、およびこれを用いたマウス用気管内チューブの挿管方法を提供することにある。 The present invention has been made based on the circumstances as described above, and its object is to make it possible to intubate the endotracheal tube of a mouse reliably, quickly and easily without using expensive equipment. An auxiliary tool and an intubation method for an endotracheal tube for a mouse using the same.

 本開示のいくつかの態様は、
(1)気管内チューブを喉頭を介してマウスの気管内へ案内する補助具であって、
 内部に前記気管内チューブを挿通する通孔を有するシャフト本体、を具備したシャフト部材と、
 このシャフト部材の一端に接続され、咽頭内における喉頭開口周囲の少なくとも一部に当接するマスク部材とを備え、
 前記マスク部材は、前記シャフト部材の通孔に連通する開口部を有し、
 前記開口部を介する前記気管内チューブの送出方向が、前記シャフト部材の先端方向に対して鋭角となるように形成されていることを特徴とする補助具、
(2)マスク部材が、気管内チューブの進行方向を偏向する偏向部を有している前記(1)に記載の補助具、
(3)内部に気管内チューブを挿通可能に形成されかつシャフト部材の通孔に連通すると共に、前記気管内チューブの進行方向を偏向する湾曲形状のパイプ部材を備えている前記(1)に記載の補助具、
(4)先端がシャフト部材の軸方向におけるシャフト本体の中途に位置し、前記シャフト本体の外周面から突設した突出部材を備えている前記(1)から(3)のいずれか1項に記載の補助具、
(5)突出部材が、シャフト部材の軸と開口部の中心とを通る仮想平面に対して対称となるように配置されている前記(4)に記載の補助具、
(6)シャフト部材は、開口部の基端方向の端部から前記シャフト部材の基端方向に沿った所定距離の外周部に、マーカを有している前記(1)から(5)のいずれか1項に記載の補助具、
(7)開口部を介する気管内チューブの送出方向が、シャフト部材の先端方向に対して4°以上30°以下となるように形成されている前記(1)から(6)のいずれか1項に記載の補助具、および
(8)気管内チューブを喉頭を介してマウスの気管内へ案内するマウス用気管内チューブの挿管方法であって、
 前記(1)から(7)のいずれか1項に記載の補助具を、当該補助具の先端方向から前記マウスの咽頭内に挿入する第1ステップと、
 前記第1ステップの後、マスク部材を前記咽頭内における喉頭開口周囲に当接させる第2ステップと、
 前記第2ステップの後、前記補助具を介して前記気管内チューブを前記マウスの気管内に挿管する第3ステップとを備えていることを特徴とする挿管方法
である。
Some aspects of the present disclosure are:
(1) An aid for guiding an endotracheal tube into the trachea of a mouse via the larynx,
A shaft member having a through hole through which the endotracheal tube is inserted;
A mask member connected to one end of the shaft member and abutting at least a part of the periphery of the laryngeal opening in the pharynx;
The mask member has an opening communicating with the through hole of the shaft member,
An auxiliary tool characterized in that a delivery direction of the endotracheal tube through the opening is formed at an acute angle with respect to a distal direction of the shaft member.
(2) The auxiliary tool according to the above (1), wherein the mask member has a deflection unit that deflects the advancing direction of the endotracheal tube.
(3) The tube according to the above (1), which is formed so as to allow the endotracheal tube to be inserted therein and communicate with the through hole of the shaft member and has a curved pipe member for deflecting the advancing direction of the endotracheal tube. Auxiliary equipment,
(4) The tip is located in the middle of the shaft body in the axial direction of the shaft member, and includes a projecting member protruding from the outer peripheral surface of the shaft body according to any one of (1) to (3) Auxiliary equipment,
(5) The auxiliary tool according to (4), wherein the projecting members are arranged to be symmetrical with respect to a virtual plane passing through the axis of the shaft member and the center of the opening.
(6) The shaft member has a marker at an outer peripheral portion of a predetermined distance along the proximal end direction of the shaft member from the end of the opening in the proximal direction, any of the above (1) to (5) Auxiliaries listed in paragraph 1 or
(7) Any one of the above items (1) to (6), wherein the delivery direction of the endotracheal tube through the opening is formed so as to be 4 ° or more and 30 ° or less with respect to the distal end direction of the shaft member And (8) a method of intubating an endotracheal tube for a mouse, which guides the endotracheal tube into the endotracheal space of the mouse through the larynx.
A first step of inserting the aid according to any one of (1) to (7) into the pharynx of the mouse from the tip direction of the aid;
After the first step, a second step of bringing a mask member into contact with the laryngeal opening in the pharynx;
After the second step, a third step of intubating the endotracheal tube into the trachea of the mouse via the auxiliary tool is provided.

 なお、本明細書において、「先端方向」とは、シャフト部材の軸方向に沿う方向であって、シャフト部材のマスク部材が設けられていない端部に対するマスク部材が設けられている端部の方向を意味する。また、「基端方向」とは、シャフト部材の軸方向に沿う方向であって、先端方向と反対側の方向を意味する。また、「先端」とは、任意の部材または部位における先端方向の端部、「基端」とは、任意の部材または部位における基端方向の端部をそれぞれ示す。「所定距離」とは、マウスの口腔および咽頭に沿った長さであってマウスの身体の特定部位(例えば門歯など)と喉頭開口との間の標準的な長さ、に対応するように定められた距離を意味する。 In the present specification, the “tip direction” is a direction along the axial direction of the shaft member, and is the direction of the end where the mask member is provided with respect to the end where the mask member of the shaft member is not provided. Means Also, “proximal direction” means a direction along the axial direction of the shaft member and means the direction opposite to the distal direction. Also, “distal end” indicates the distal end of any member or site, and “proximal” indicates the proximal end of any member or site. The "predetermined distance" is defined as the length along the mouth and pharynx of the mouse and corresponds to the standard length between a specific part of the mouse body (for example, incisor teeth) and the laryngeal opening. Means the distance

 本発明は、高価な器具を用いることなく、気管内チューブを確実、迅速かつ容易にマウスの気管内に挿管することが可能な補助具、およびこれを用いたマウス用気管内チューブの挿管方法を提供することができる。 The present invention provides an aid capable of reliably, quickly and easily intubating the endotracheal tube of the endotracheal tube without using an expensive instrument, and a method of intubating the endotracheal tube for a mouse using the same. Can be provided.

本発明の第1の実施形態を示す概略断面図である。It is a schematic sectional drawing which shows the 1st Embodiment of this invention. 図1の概略平面図である。It is a schematic plan view of FIG. 本発明の補助具における各部の寸法を説明するための概略図であって、(a)は断面図を、(b)は平面図をそれぞれ示している。It is the schematic for demonstrating the dimension of each part in the auxiliary tool of this invention, Comprising: (a) is sectional drawing, (b) has shown the top view, respectively. 本発明の第2の実施形態を示す概略断面図である。It is a schematic sectional drawing which shows the 2nd Embodiment of this invention. 図4の概略平面図である。FIG. 5 is a schematic plan view of FIG. 4; 本発明の第3の実施形態を示す概略平面図であって、(a)~(d)はそれぞれ各種形状の突出部材を備えている補助具を示している。FIG. 10 is a schematic plan view showing a third embodiment of the present invention, wherein (a) to (d) show an assisting tool provided with projecting members of various shapes. 本発明の第3の実施形態を示す概略側面図であって、(a)~(f)はそれぞれ各種形状の突出部材を備えている補助具を示している。It is a schematic side view showing a 3rd embodiment of the present invention, and (a)-(f) show the auxiliary tool provided with the projection member of various shapes, respectively. 図1の使用状態を示す概略図であって、(a)は補助具を口腔内に挿入した状態、(b)は補助具のマスク部材を喉頭に押し当てた状態、(c)は気管内チューブを挿入する過程の状態、(d)は気管内チューブを気管内に挿入した状態をそれぞれ示している。It is the schematic which shows the use condition of FIG. 1, Comprising: (a) is a state which inserted the auxiliary tool in the intraoral area, (b) is a state which pressed the mask member of the auxiliary tool to the larynx, (c) is the endotracheal region. (D) shows a state in which an endotracheal tube is inserted into the trachea.

<補助具>
 本発明の一実施形態の補助具は、気管内チューブを喉頭を介してマウスの気管内へ案内する補助具であって、内部に上記気管内チューブを挿通する通孔を有するシャフト本体、を具備したシャフト部材と、このシャフト部材の一端に接続され、咽頭内における喉頭開口周囲の少なくとも一部に当接するマスク部材とを備え、上記マスク部材は、上記シャフト部材の通孔に連通する開口部を有し、上記開口部を介する上記気管内チューブの送出方向が、上記シャフト部材の先端方向に対して鋭角となるように形成されていることを特徴とする。
<Auxiliary tools>
The auxiliary tool according to one embodiment of the present invention is an auxiliary tool for guiding an endotracheal tube into the trachea of a mouse via the larynx, and includes a shaft body having a through hole through which the endotracheal tube is inserted. And a mask member connected to one end of the shaft member and in contact with at least a part of the periphery of the larynx opening in the pharynx, the mask member having an opening communicating with the through hole of the shaft member It is characterized in that the delivery direction of the endotracheal tube through the opening portion is formed to have an acute angle with respect to the distal direction of the shaft member.

 なお、当該補助具に適用される気管内チューブは、補助具の通孔に沿って湾曲可能な柔軟性を有するチューブであり、例えば、この気管内チューブを介して麻酔ガスや酸素などの気体を気管に送気したり、気管からの呼気を外部に排気する。この気管内チューブの外径は、0.8mm~1.2mm程度である。 The endotracheal tube applied to the auxiliary tool is a flexible tube that can be bent along the through hole of the auxiliary tool, and for example, gas such as anesthetic gas or oxygen is transmitted through the endotracheal tube. Supply air to the trachea or exhale from the trachea to the outside. The outer diameter of the endotracheal tube is about 0.8 mm to 1.2 mm.

 以下、本発明の第1~第3の実施形態について図面を参照して説明するが、本発明は、当該図面に記載の実施形態にのみ限定されるものではない。 Hereinafter, the first to third embodiments of the present invention will be described with reference to the drawings, but the present invention is not limited to only the embodiments described in the drawings.

[第1の実施形態]
 図1は、本発明の第1の実施形態を示す概略断面図である。当該補助具1は、図1に示すように、概略的に、シャフト部材11と、マスク部材21とにより構成されている。
First Embodiment
FIG. 1 is a schematic cross-sectional view showing a first embodiment of the present invention. The said auxiliary | assistant tool 1 is roughly comprised by the shaft member 11 and the mask member 21 as shown in FIG.

 シャフト部材11は、シャフト本体110を具備する。また、シャフト部材11は、マーカ120を有していてもよい。 The shaft member 11 comprises a shaft body 110. The shaft member 11 may also have a marker 120.

 シャフト本体110は、内部に気管内チューブtを挿通する通孔111を有する部材である。このシャフト本体110は、具体的には、例えば、内部がシャフト部材11の軸(シャフト本体110の軸)方向に沿って貫通する通孔111を有するように略円筒形状に形成されている。 The shaft main body 110 is a member having a through hole 111 through which the endotracheal tube t is inserted. Specifically, the shaft body 110 is formed in, for example, a substantially cylindrical shape so as to have a through hole 111 which penetrates along the direction of the axis of the shaft member 11 (the axis of the shaft body 110).

 シャフト本体110の各部の寸法は、マウスの口腔を通して当該補助具1を挿入する際、後述するマスク部材21の開口部211が喉頭開口まで確実に届くように、全長が通常15mm~20mmであり、マウスの咽頭内に容易に挿入できるように、外径が通常3mm~5mmである。内径は、気管内チューブtの外径にもよるが、通常1mm~2mmである。 The dimensions of each part of the shaft body 110 are generally 15 mm to 20 mm in total length so that when the auxiliary tool 1 is inserted through the oral cavity of the mouse, the opening 211 of the mask member 21 described later reliably reaches the larynx opening. The outer diameter is usually 3 mm to 5 mm so that it can be easily inserted into the pharynx of the mouse. The inner diameter is usually 1 mm to 2 mm depending on the outer diameter of the endotracheal tube t.

 シャフト本体110を構成する材料としては、特に限定されないが、咽頭に沿って当該補助具1を円滑に挿入できる観点から、可撓性を有する材料で形成されていることが好ましく、ポリエステル樹脂、塩ポリ化ビニル樹脂がより好ましく、ポリエステル樹脂がさらに好ましい。また、シャフト本体110は、上記材料を用いて形成した部材の外周上にシリコーン樹脂などの層が積層されたものであってもよい。 The material constituting the shaft main body 110 is not particularly limited, but is preferably made of a flexible material from the viewpoint of being able to smoothly insert the auxiliary 1 along the pharynx, and polyester resin, salt Polyvinylated resins are more preferred, and polyester resins are even more preferred. Further, the shaft body 110 may be one in which a layer such as silicone resin is laminated on the outer periphery of a member formed using the above-mentioned material.

 マーカ120は、マウスの咽頭内におけるマスク部材21の開口部211の位置を把握するための目印である。このマーカ120は、シャフト本体110の表面上であって、開口部211の基端方向の端部pからシャフト部材11の基端方向に沿った所定距離L4(図3参照)の外周部に設けられている。マーカ120としては、例えば、上記外周部における円周方向の一部または全周が顔料等で着色されたもの、上記外周部における円周方向の一部または全周に凸部や凹部などの形状的な特徴部位が形成されたもの等を採用することができる。本実施形態では、外周部の全周に顔料を用いて着色したマーカ120(図1、図2参照)が例示されている。 The marker 120 is a mark for grasping the position of the opening 211 of the mask member 21 in the pharynx of the mouse. The marker 120 is provided on the surface of the shaft body 110 and at an outer peripheral portion of a predetermined distance L4 (see FIG. 3) along the proximal direction of the shaft member 11 from the end p of the opening 211 in the proximal direction. It is done. As the marker 120, for example, a part or the whole circumference in the circumferential direction in the outer peripheral part is colored with a pigment or the like, and a shape such as a convex part or a recess around the part or the entire circumference in the circumferential direction in the outer peripheral part It is possible to employ one in which a typical feature portion is formed. In the present embodiment, a marker 120 (see FIG. 1 and FIG. 2) colored using a pigment is illustrated on the entire circumference of the outer peripheral portion.

 ここで、所定距離L4としては、例えば、標準的なマウスの門歯と喉頭開口との間の平均的な長さと同一の値を採用することができる。この場合、マーカ120とマスク部21の端部pとの距離が11mm以上12mm以下であることが好ましく、11.6mmであることがより好ましい。これにより、マーカ120を門歯に合わせることで、咽頭内を視ることなく、開口部211を喉頭開口により正確に合わせることができる。 Here, as the predetermined distance L4, for example, the same value as the average length between the incisor teeth and the laryngeal opening of a standard mouse can be adopted. In this case, the distance between the marker 120 and the end p of the mask portion 21 is preferably 11 mm or more and 12 mm or less, and more preferably 11.6 mm. Thus, by aligning the marker 120 with the incisor tooth, the opening 211 can be more accurately aligned with the laryngeal opening without looking at the inside of the pharynx.

 マスク部材21は、シャフト部材11の一端に接続され、咽頭内における喉頭開口周囲の少なくとも一部に当接する。このマスク部材21は、図2に示すように、シャフト部材11の通孔111に連通する開口部211を有している。具体的には、マスク部材21は、例えば、基端がシャフト本体110先端の開口周囲を取り囲むように固定され、上記開口周囲から先端方向に向かって延設されていると共に、内部にシャフト部材11の通孔111と連通する気管内チューブt挿通用の通孔212を有している。なお、この通孔212と上述した通孔111とにより気管内チューブtを挿通可能なルーメン301が形成される。 The mask member 21 is connected to one end of the shaft member 11 and abuts on at least a part of the larynx opening periphery in the pharynx. As shown in FIG. 2, the mask member 21 has an opening 211 communicating with the through hole 111 of the shaft member 11. Specifically, the mask member 21 is, for example, fixed so that the proximal end surrounds the opening of the distal end of the shaft main body 110, extends from the periphery of the opening toward the distal direction, And a through hole 212 for insertion of the endotracheal tube t in communication with the through hole 111. A lumen 301 through which the endotracheal tube t can be inserted is formed by the through hole 212 and the through hole 111 described above.

 マスク部材21の開口部211周囲の表面形状は、マウスの咽頭内における喉頭開口周囲の形状に見合うように形成することが好ましく、これによりマスク部材21が喉頭開口に安定して着座し、気管と補助具1のルーメン301とを確実に導通することができる。 The surface shape around the opening 211 of the mask member 21 is preferably formed to correspond to the shape around the larynx opening in the pharynx of the mouse, whereby the mask member 21 is stably seated in the larynx opening and the trachea The lumen 301 of the auxiliary tool 1 can be reliably conducted.

 マスク部材21の各部の寸法(図3参照)は、咽頭および喉頭開口の形状を考慮し、通常、全長L1が2mm~11mm、最大幅L2が2mm~5mm、最大高さL3が2mm~6mmである。マスク部材21の開口部211は、喉頭開口の形状を考慮し、通常、全長L5が4mm~6mm、最大幅L6が1mm~2mmである。 The dimensions of each part of the mask member 21 (see FIG. 3) are usually 2 mm to 11 mm in total length L1, 2 mm to 5 mm in maximum width L2, and 2 mm to 6 mm in maximum height L3 in consideration of the shape of the pharynx and larynx opening. is there. The opening 211 of the mask member 21 usually has a total length L5 of 4 mm to 6 mm and a maximum width L6 of 1 mm to 2 mm in consideration of the shape of the larynx opening.

 マスク部材21の先端部の形状は、湾曲形状(いずれの方向から見てもマスク部材21の先端部が尖っていない形状、図1、図2参照)であることが好ましい。このように、マスク部材21の先端部の形状が湾曲形状であることで、マスク部材21(マスク部材21の先端部)の接触に伴うマウスの感覚受容器への刺激を低減することができ、例えば、反射による呼吸障害などが発生するのを抑制することができる。 The shape of the tip end portion of the mask member 21 is preferably a curved shape (a shape in which the tip end portion of the mask member 21 is not sharp when viewed from any direction, see FIGS. 1 and 2). As described above, since the shape of the tip of the mask member 21 is a curved shape, it is possible to reduce the stimulation on the sensory receptor of the mouse accompanying the contact of the mask member 21 (the tip of the mask member 21). For example, it is possible to suppress the occurrence of respiratory disorder and the like due to reflection.

 マスク部材21を構成する材料としては、例えば、樹脂材料等が挙げられる。これらの中で、上記材料としては、咽頭内壁の粘膜への接触による刺激を軽減する観点から、シリコーン樹脂、ウレタン樹脂が好ましく、シリコーン樹脂がより好ましい。 As a material which comprises the mask member 21, a resin material etc. are mentioned, for example. Among these, as the above-mentioned material, a silicone resin and a urethane resin are preferable, and a silicone resin is more preferable, from the viewpoint of reducing the irritation due to the contact with the mucous membrane of the pharyngeal inner wall.

 このマスク部材21の形成方法としては、例えば、硬化前の樹脂材料が装填された吐出装置(不図示)を用い、この吐出装置により吐出した樹脂材料をシャフト本体110先端に塗布して常温または熱硬化させることで形成する方法、シャフト本体110先端を型(不図示)に装着し、シャフト本体110の開口周囲に硬化前の樹脂材料を充填してこれを熱硬化させることで形成する方法等を採用することができる。 As a method of forming the mask member 21, for example, using a discharge device (not shown) in which a resin material before curing is loaded, the resin material discharged by the discharge device is applied to the tip of the shaft main body 110 and room temperature or heat A method of forming by curing, a method of mounting the tip of the shaft body 110 on a die (not shown), filling the resin material before curing around the opening of the shaft body 110 and thermally curing the same It can be adopted.

 ここで、当該補助具1は、開口部211を介する気管内チューブtの送出方向a2が、シャフト部材11の先端方向a1に対して鋭角(送出角度θ<90°、図3参照)となるように形成されている。これにより、当該補助具1をマウスの口腔内に挿通する際、開口部211から送出する気管内チューブtを喉頭の方向に向けることができる。 Here, in the auxiliary tool 1, the delivery direction a2 of the endotracheal tube t through the opening 211 is such that the delivery direction a2 of the endotracheal tube t is an acute angle (delivery angle θ <90 °, see FIG. 3) with respect to the tip direction a1 of the shaft member 11. Is formed. Thereby, when inserting the said auxiliary tool 1 in the intraoral area of a mouse | mouth, the endotracheal tube t delivered from the opening part 211 can be orient | assigned to the direction of a larynx.

 なお、開口部211を介する気管内チューブtの送出方向a2は、シャフト部材11の先端方向a1に対して4°以上30°以下であることが好ましく、5°以上25°以下であることがより好ましく、6°以上22°以下であることが更に好ましい。これにより、気管内チューブtの送出方向a2を気管の方向により正確に向けることができ、気管内チューブtをより確実にマウスの気管内に挿管することができる。 The delivery direction a2 of the endotracheal tube t through the opening 211 is preferably 4 ° or more and 30 ° or less, more preferably 5 ° or more and 25 ° or less with respect to the distal end direction a1 of the shaft member 11 Preferably, it is more preferably 6 ° or more and 22 ° or less. As a result, the delivery direction a2 of the endotracheal tube t can be more accurately directed to the trachea direction, and the endotracheal tube t can be more reliably intubated into the trachea of the mouse.

 気管内チューブtの送出方向a2を鋭角にするための構成としては特に限定されず、例えば、本実施形態のように、マスク部材21が気管内チューブtの進行方向を偏向する偏向部31を有していてもよい。具体的には、偏向部31としては、図1に示すように、例えば、マスク部材21の開口部211近傍の内周に形成された隆起状の部位311等を採用することができる。なお、偏向部31は、マスク部材21と一体であっても別体であってもよい。 The configuration for making the delivery direction a2 of the endotracheal tube t acute is not particularly limited. For example, as in the present embodiment, the mask member 21 has a deflection portion 31 that deflects the advancing direction of the endotracheal tube t. It may be done. Specifically, as shown in FIG. 1, for example, a raised portion 311 or the like formed on the inner periphery in the vicinity of the opening 211 of the mask member 21 can be employed as the deflection unit 31. The deflection unit 31 may be integral with or separate from the mask member 21.

 このように、マスク部材21が偏向部31を有していることで、当該補助具1は、通孔111を通過した気管内チューブtの進行方向を、偏向部31との接触によりシャフト部材11の先端方向a1に対して鋭角に偏向することができ、簡易な構成で気管内チューブtをマウスの気管内に挿管することができる。 Thus, by the mask member 21 having the deflecting portion 31, the auxiliary tool 1 is configured such that the advancing direction of the endotracheal tube t which has passed through the through hole 111 is the shaft member 11 by contact with the deflecting portion 31. The endotracheal tube t can be intubated into the trachea of the mouse with a simple configuration.

 なお、当該補助具1の使用態様については、<マウス用気管内チューブの挿管方法>の項で後述する。 In addition, about the usage aspect of the said auxiliary tool 1, it mentions later by the term of <intubation method of the endotracheal tube for mice>.

 以上のように、当該補助具1は、上記構成であるので、当該補助具1を用いてマウス用の気管内チューブtを気管内に挿管する際、気管内チューブtの送出方向a2が先端方向a1に対して鋭角である分、この気管内チューブtが食道に入ることなく喉頭を介して気管に挿管することができ、内視鏡のような高価な器具を用いることなく、気管内チューブtを確実、迅速かつ容易にマウスの気管内に挿管することができる。また、本実施形態では、シャフト部材11がマーカ120を有しているので、マスク部材21の開口部211をマウスの喉頭開口により正確に合わせることができる。 As mentioned above, since the said auxiliary tool 1 is the said structure, when intubating the endotracheal tube t for mice in the trachea using the said auxiliary tool 1, the delivery direction a2 of the endotracheal tube t is a tip direction Since the endotracheal tube t can be inserted into the trachea via the larynx without entering the esophagus because it has an acute angle with respect to a1, the endotracheal tube t can be used without using an expensive instrument such as an endoscope. The tube can be intubated into the trachea of the mouse quickly and easily. Further, in the present embodiment, since the shaft member 11 has the marker 120, the opening 211 of the mask member 21 can be accurately aligned with the laryngeal opening of the mouse.

[第2の実施形態]
 図4は、本発明の第2の実施形態を示す概略断面図である。当該補助具2は、図4に示すように、概略的に、シャフト部材11と、マスク部材21と、パイプ部材52とにより構成されている。本実施形態は、パイプ部材52を備えている点で、第1の実施形態と異なっている。なお、シャフト部材11およびマスク部材21の構成は、第1の実施形態のものと同様であるので、同一部分には同一符号を付してその詳細な説明は省略する。また、当該補助具2の使用態様についても、後述する<マウス用気管内チューブの挿管方法>の項での説明を援用する。
Second Embodiment
FIG. 4 is a schematic cross-sectional view showing a second embodiment of the present invention. The said auxiliary | assistant tool 2 is roughly comprised by the shaft member 11, the mask member 21, and the pipe member 52, as shown in FIG. The present embodiment differs from the first embodiment in that the pipe member 52 is provided. In addition, since the structure of the shaft member 11 and the mask member 21 is the same as that of the thing of 1st Embodiment, the same code | symbol is attached | subjected to an identical part and the detailed description is abbreviate | omitted. Moreover, the description in the section of <Method for intubating endotracheal tube for mice> described later is also used for the mode of use of the auxiliary tool 2.

 パイプ部材52は、内部に気管内チューブtを挿通可能に形成されかつシャフト部材11の通孔111に連通すると共に、気管内チューブtの進行方向を偏向する湾曲形状の部材である。本実施形態では、パイプ部材52は、基端がシャフト本体110の通孔111に挿入され、この挿入されたパイプ部材52の外周とシャフト本体110の内周とが密着するように固定されている。また、パイプ部材52は、図5に示すように、先端の開口端面522がマスク部材21の開口部211に臨むように配置されている。また、パイプ部材52は、開口部211からの気管内チューブtの送出方向a2が先端方向a1に対して鋭角となるように、先端と基端との間の中途にて略円弧状の湾曲形状に形成されている。なお、パイプ部材52の通孔521と通孔111とにより気管内チューブtを挿通可能なルーメン302が形成される。 The pipe member 52 is a curved member which is formed so as to allow the endotracheal tube t to be inserted therein, communicates with the through hole 111 of the shaft member 11, and deflects the advancing direction of the endotracheal tube t. In the present embodiment, the pipe member 52 has its proximal end inserted into the through hole 111 of the shaft body 110 and is fixed so that the outer periphery of the inserted pipe member 52 and the inner periphery of the shaft body 110 are in close contact. . Further, as shown in FIG. 5, the pipe member 52 is disposed such that the opening end surface 522 at the tip end faces the opening 211 of the mask member 21. In addition, the pipe member 52 has a substantially arc-like curved shape in the middle between the distal end and the proximal end such that the delivery direction a2 of the endotracheal tube t from the opening 211 is acute at the distal direction a1. Is formed. The through hole 521 of the pipe member 52 and the through hole 111 form a lumen 302 through which the endotracheal tube t can be inserted.

 パイプ部材52と構成する材料としては、例えば、ステンレス鋼、チタン合金、コバルトクロム合金等が挙げられる。これらの中で、パイプ部材52と構成する材料としては、作製容易性の観点から、ステンレス鋼が好ましく、SUS304がより好ましい。 As a material which comprises pipe member 52, stainless steel, a titanium alloy, a cobalt chromium alloy etc. are mentioned, for example. Among them, stainless steel is preferable as a material to be configured with the pipe member 52, and SUS304 is more preferable, from the viewpoint of ease of preparation.

 以上のように、当該補助具2は、上記構成であるので、通孔111内を通過した気管内チューブtの進行方向を、パイプ部材52の湾曲形状に沿うようにシャフト部材11の先端方向a1に対して鋭角に偏向(送出方向a2)することができ、簡易な構成で気管内チューブtをマウスの気管内に挿管することができる。 As mentioned above, since the said auxiliary tool 2 is the said structure, the front end direction a1 of the shaft member 11 is carried out so that the advancing direction of the endotracheal tube t which passed through the inside of the through-hole 111 may follow the curve shape of the pipe member 52. The endotracheal tube t can be intubated into the trachea of the mouse with a simple configuration.

[第3の実施形態]
 図6および図7は、それぞれ本発明の第3の実施形態を示す概略平面図および概略側面図である。当該補助具3(3m1~3m10)は、図6、図7に示すように、概略的に、シャフト部材11と、マスク部材21と、突出部材63とにより構成されている。本実施形態は、突出部材63を備えている点で第1の実施形態と異なっている。なお、シャフト部材11およびマスク部材21の構成は、第1の実施形態のものと同様であるので、同一部分には同一符号を付してその詳細な説明は省略する。また、当該補助具3の使用態様についても、後述する<マウス用気管内チューブの挿管方法>の項での説明を援用する。
Third Embodiment
6 and 7 are a schematic plan view and a schematic side view, respectively, showing a third embodiment of the present invention. The auxiliary tool 3 (3 m1 to 3 m10) is roughly configured by the shaft member 11, the mask member 21 and the projecting member 63, as shown in FIGS. The present embodiment differs from the first embodiment in that a projecting member 63 is provided. In addition, since the structure of the shaft member 11 and the mask member 21 is the same as that of the thing of 1st Embodiment, the same code | symbol is attached | subjected to an identical part and the detailed description is abbreviate | omitted. Moreover, the description in the section of <Method of intubating endotracheal tube for mouse> described later is also used for the usage mode of the auxiliary tool 3.

 突出部材63は、先端がシャフト部材11の軸方向におけるシャフト本体110の中途に位置し、シャフト本体110の外周面から突設した部材である。この突出部材63は、例えば、その一部がシャフト本体110の外周に接着剤等を用いて固着され、シャフト本体110の外方に向かって延伸するように形成することができる。 The projecting member 63 is a member whose tip is located in the middle of the shaft body 110 in the axial direction of the shaft member 11 and protrudes from the outer peripheral surface of the shaft body 110. For example, a part of the projecting member 63 may be fixed to the outer periphery of the shaft body 110 using an adhesive or the like, and may be formed to extend outward of the shaft body 110.

 突出部材63の具体的な形状としては、平面視の形状として、例えば、三角形状のもの(図6(a)の突出部材63m1参照)、矩形状のもの(図6(b)の突出部材63m2参照)、段階的に幅が変化する形状のもの(図6(c)の突出部材63m3参照)、シャフト本体110の片側にのみ突設したもの(図6(d)の突出部材63m4参照)等、側面視の形状として、例えば、シャフト本体110から放射状に延びる形状のもの(図7(a)~図7(d)の突出部材63m5~63m8参照)、シャフト本体110に外接する形状のもの(図7(e)、図7(f)の突出部材63m9、63m10参照)等を採用することができる。ここで、上述にて例示した平面視の形状と側面視の形状とは、可能な範囲で任意に組み合わせることができる。 The specific shape of the projecting member 63 is, for example, a triangular shape (see the projecting member 63m1 of FIG. 6A) or a rectangular shape (the projecting member 63m2 of FIG. 6B) as a shape in plan view. See the following), in a shape that changes gradually in width (see the projection member 63m3 in FIG. 6 (c)), those projecting only on one side of the shaft body 110 (see the projection member 63m4 in FIG. 6 (d)), etc. As a shape in a side view, for example, a shape extending radially from the shaft body 110 (see the projecting members 63m5 to 63m8 in FIGS. 7A to 7D) and a shape circumscribing the shaft body 110 (see FIGS. 7A to 7D) 7 (e) and 7 (f) can be adopted. Here, the shape of the planar view and the shape of the side view exemplified above may be combined arbitrarily within the possible range.

 なお、突出部材63は、シャフト部材11の軸と開口部211の中心とを通る仮想平面bに対して対称となるように配置されていることが好ましい(図6(a)~図6(c)、図7(a)、図7(b)、図7(d)~図7(f)参照)。これにより、当該補助具3をマウスの口腔内に挿入する際、シャフト部材11の軸を咽頭の軸中心に可及的に近づけることができ、マスク部材21を咽頭開口により安定して着座させることができる。 The projecting members 63 are preferably arranged to be symmetrical with respect to an imaginary plane b passing through the axis of the shaft member 11 and the center of the opening 211 (FIGS. 6A to 6C (c). 7 (a), 7 (b) and 7 (d) to 7 (f)). Thereby, when inserting the said auxiliary tool 3 in the intraoral area of a mouse | mouth, the axis of the shaft member 11 can be closely approached as much as possible to the axial center of the pharynx, and the mask member 21 is seated stably by the pharyngeal opening. Can.

 また、平面視において、シャフト部材11の軸に直交する方向における突出部材63の最大幅は、突出部材63先端の幅よりも大きいことが好ましい(図6(a)、図6(c)参照)。これにより、当該補助具3をマウスの口腔内に円滑に挿入することができる。 Further, in plan view, the maximum width of the projecting member 63 in the direction orthogonal to the axis of the shaft member 11 is preferably larger than the width of the tip of the projecting member 63 (see FIGS. 6A and 6C). . Thereby, the said auxiliary tool 3 can be smoothly inserted in the oral cavity of a mouse | mouth.

 また、突出部材63は、全体として扁平形状(略扁平形状)に形成されていることが好ましい(図7(a)~図7(c)、図7(e)、図7(f)参照)。これにより、突出部材63をマウスの特徴である横断面の内周が扁平な口腔形状に対応させる(沿わせる)ことができ、マスク部材21を咽頭開口にさらに安定して着座させることができる。 Further, the projecting member 63 is preferably formed in a flat shape (substantially flat shape) as a whole (see FIGS. 7A to 7C, and FIGS. 7E and 7F). . As a result, the projecting member 63 can be made to correspond to (follow along) the flat oral cavity shape of the cross section which is the feature of the mouse, and the mask member 21 can be seated on the pharyngeal opening more stably.

 以上のように、当該補助具3は、上記構成であるので、マウスの口腔内に安定して着座させることができる。 As mentioned above, since the said auxiliary tool 3 is the said structure, it can be stably seated in the oral cavity of a mouse | mouth.

<マウス用気管内チューブの挿管方法>
 本発明の一実施形態のマウス用気管内チューブの挿管方法は、気管内チューブを喉頭を介してマウスの気管内へ案内するマウス用気管内チューブの挿管方法であって、当該補助具を、当該補助具の先端方向から上記マウスの咽頭内に挿入する第1ステップと、上記第1ステップの後、マスク部材を上記咽頭内における喉頭開口周囲に当接させる第2ステップと、上記第2ステップの後、上記補助具を介して上記気管内チューブを上記マウスの気管内に挿管する第3ステップとを備えていることを特徴とする。
<Method for intubating endotracheal tube for mice>
The method of intubating a mouse endotracheal tube according to an embodiment of the present invention is a method of intubating a mouse endotracheal tube for guiding the endotracheal tube into the trachea of a mouse via the larynx, and A first step of inserting the tip of the assisting tool into the pharynx of the mouse, a second step of bringing the mask member into contact with the periphery of the laryngeal opening in the pharynx after the first step, and And a third step of intubating the endotracheal tube into the trachea of the mouse through the aid.

 以下、当該挿管方法について詳述する。ここでは、補助具として、<補助具>の項の第1の実施形態にて上述したものを例に取り、図8を参照して説明する。 Hereinafter, the intubation method will be described in detail. Here, as the assisting tool, the one described above in the first embodiment of the item of <assisting tool> will be described as an example with reference to FIG.

[第1ステップ]
 第1ステップでは、当該補助具1を、当該補助具1の先端方向からマウスmの咽頭m3内に挿入する。具体的には、図8(a)に示すように、マウスmの口腔m2に補助具1を挿入した後、この補助具1を、例えば、マーカ120を有する場合は、マーカ120がマウスmの門歯m1の位置に達するまで咽頭m3に押し入れたり、マーカ120を有しない場合は、補助具1の押し込み抵抗が変化(増加)するまで咽頭m3に押し入れることで、補助具1を適正な位置に挿入する。
[First step]
In the first step, the auxiliary tool 1 is inserted into the throat m3 of the mouse m from the distal direction of the auxiliary tool 1. Specifically, as shown in FIG. 8A, after inserting the assisting tool 1 into the oral cavity m2 of the mouse m, if the assisting tool 1 has the marker 120, for example, the marker 120 is the mouse m Push the larynx m3 until the position of the incisor m1 is reached, or if the marker 120 is not provided, push the laryngeal m3 until the pressing resistance of the auxiliary 1 changes (increases), the auxiliary 1 is put in the proper position insert.

[第2ステップ]
 第2ステップでは、上述した第1ステップを実行した後、図8(b)に示すように、マスク部材21を喉頭m3方向に移動させ、このマスク部材21表面を咽頭m3内における喉頭開口m5周囲に当接させる。この際、マスク部材21は、少なくともその一部が単に喉頭開口m5周囲に接触していればよく、喉頭開口m5周囲を完全に覆う必要はない。
[The second step]
In the second step, after performing the above-mentioned first step, as shown in FIG. 8 (b), the mask member 21 is moved in the direction of the larynx m3, and the surface of the mask member 21 is around the larynx opening m5 in the pharynx m3. Abut on. At this time, at least a part of the mask member 21 may simply be in contact with the periphery of the larynx opening m5, and it is not necessary to completely cover the periphery of the larynx opening m5.

 ここで、マスク部材21表面の一部を喉頭蓋m6に接触させることで、喉頭蓋m6が喉頭開口m5を閉じないように、喉頭蓋m6の表面を支承することが好ましい。これにより、後述する気管内チューブtの気管m7内への挿入をより円滑に行うことができる。 Here, it is preferable that the surface of the epiglottis m6 be supported such that the epiglottis m6 does not close the laryngeal opening m5 by bringing the surface of the mask member 21 into contact with the epiglottis m6. Thereby, the insertion of the endotracheal tube t described later into the trachea m7 can be performed more smoothly.

[第3ステップ]
 第3ステップでは、上述した第2ステップを実行した後、補助具1を介して気管内チューブtをマウスmの気管m7内に挿管する。具体的には、シャフト部材11の基端開口112から気管内チューブtを挿入し、この気管内チューブtを通孔111、通孔212の順で押し進め(図8(c)参照)、気管内チューブtの先端を喉頭m4を介して気管m7内に挿管する(図8(d)参照)。
[Third step]
In the third step, after performing the second step described above, the endotracheal tube t is intubated into the trachea m7 of the mouse m through the auxiliary tool 1. Specifically, an endotracheal tube t is inserted from the proximal end opening 112 of the shaft member 11, and the endotracheal tube t is pushed forward in the order of the through hole 111 and the through hole 212 (see FIG. 8 (c)). The distal end of the tube t is intubated into the trachea m7 via the larynx m4 (see FIG. 8 (d)).

 なお、気管内チューブtを気管m7内に挿管した後は、例えば、この気管内チューブtに接続されたレスピレータ等を用いて麻酔ガスの送気や呼吸の促進などのような所望の処置を行うことができ、上記処置を実行した後、例えば、気管内チューブt、補助具1の順でこれらをマウスmの喉頭m4、咽頭m3および口腔m2から引き抜く。 After intubation of the endotracheal tube t into the trachea m7, desired treatment such as supply of anesthetic gas or promotion of respiration is performed using, for example, a respirator connected to the endotracheal tube t. After performing the above-mentioned procedure, for example, the endotracheal tube t and the aid 1 are sequentially pulled out of the larynx m4, the pharynx m3 and the oral cavity m2 of the mouse m.

 以上のように、当該挿管方法は、上記構成であるので、補助具1を用いてマウス用の気管内チューブtを気管m7内に挿管する際、気管内チューブtの送出方向a2が先端方向a1に対して鋭角である分、この気管内チューブtを食道m8に入ることなく喉頭m4を介して気管m7に挿管することができ、内視鏡のような高価な器具を用いることなく、気管内チューブtを確実、迅速かつ容易にマウスmの気管m7内に挿管することができる。 As described above, since the intubation method has the above configuration, when the endotracheal tube t for a mouse is intubated in the trachea m7 using the auxiliary tool 1, the delivery direction a2 of the endotracheal tube t is the distal direction a1. The endotracheal tube t can be intubated to the trachea m7 through the larynx m4 without entering the esophagus m8 because it has an acute angle with respect to the The tube t can be intubated in the trachea m7 of the mouse m reliably, quickly and easily.

 なお、本発明は、上述した実施形態の構成に限定されるものではなく、特許請求の範囲によって示され、特許請求の範囲と均等の意味および範囲内での全ての変更が含まれることが意図される。 The present invention is not limited to the configurations of the above-described embodiments, but is shown by the claims, and is intended to include all modifications within the meaning and range equivalent to the claims. Be done.

 例えば、第1の実施形態ではマスク部材21が偏向部31を有する補助具1、第2の実施形態ではパイプ部材52を備えている補助具2について説明したが、開口部211を介する気管内チューブtの送出方向a2が、シャフト部材11の先端方向a1に対して鋭角となるように形成されていれば、上記補助具1、2以外の補助具であってもよい。 For example, although the first embodiment describes the auxiliary tool 1 having the deflecting portion 31 in the first embodiment, and the auxiliary tool 2 including the pipe member 52 in the second embodiment, the endotracheal tube through the opening 211 As long as the delivery direction a2 of t is formed to be an acute angle with respect to the distal direction a1 of the shaft member 11, an aid other than the aids 1 and 2 may be used.

 また、上述した実施形態では、マーカ120を有するシャフト部材11を備えている補助具1~3について説明したが、当該補助具は、マーカを有していないものであってもよい。 Further, in the embodiment described above, the aids 1 to 3 including the shaft member 11 having the marker 120 have been described, but the aid may not have the marker.

 また、<マウス用気管内チューブの挿管方法>の項では、補助具1を用いた挿管方法について説明したが、本発明の挿管方法に用いる補助具は、本発明に係るいずれの態様の補助具であってもよく、例えば、補助具3を用いることもできる。この場合、上述した挿管方法の第1ステップにおいて、突出部材63を口腔m2内壁に沿わせるようにマウスmの咽頭m3内に挿入することが好ましい。 Moreover, although the intubation method using the auxiliary tool 1 was described in the section of <Intubation method of endotracheal tube for mouse>, the auxiliary implement used in the intubation method of the present invention is the auxiliary tool of any aspect according to the present invention. For example, the auxiliary tool 3 can also be used. In this case, in the first step of the intubation method described above, it is preferable to insert the protruding member 63 into the pharynx m3 of the mouse m so as to be along the inner wall of the oral cavity m2.

 1、2、3、3m1~3m10 補助具
 11 シャフト部材
 110 シャフト本体
 120 マーカ
 21 マスク部材
 211 開口部
 31 偏向部
 52 パイプ部材
 63、63m1~6m10 突出部材
 111、212、521 通孔
 b 仮想平面
 t 気管内チューブ
 m マウス
 m3 咽頭
 m4 喉頭
 m5 喉頭開口
1, 2, 3, 3 m1 to 3 m10 Auxiliary tool 11 Shaft member 110 Shaft body 120 Marker 21 Mask member 211 Opening 31 Deflecting portion 52 Pipe member 63, 63 m1 to 6 m10 Protruding member 111, 212, 521 Through hole b Virtual plane t Air Intratubular tube m mouse m3 larynx m4 larynx m5 laryngeal opening

Claims (8)

 気管内チューブを喉頭を介してマウスの気管内へ案内する補助具であって、
 内部に前記気管内チューブを挿通する通孔を有するシャフト本体、を具備したシャフト部材と、
 このシャフト部材の一端に接続され、咽頭内における喉頭開口周囲の少なくとも一部に当接するマスク部材とを備え、
 前記マスク部材は、前記シャフト部材の通孔に連通する開口部を有し、
 前記開口部を介する前記気管内チューブの送出方向が、前記シャフト部材の先端方向に対して鋭角となるように形成されていることを特徴とする補助具。
An aid for guiding an endotracheal tube into the trachea of a mouse via the larynx, wherein
A shaft member having a through hole through which the endotracheal tube is inserted;
A mask member connected to one end of the shaft member and abutting at least a part of the periphery of the laryngeal opening in the pharynx;
The mask member has an opening communicating with the through hole of the shaft member,
An auxiliary tool characterized in that a delivery direction of the endotracheal tube through the opening is formed at an acute angle with respect to a distal direction of the shaft member.
 マスク部材が、気管内チューブの進行方向を偏向する偏向部を有している請求項1に記載の補助具。 The auxiliary tool according to claim 1, wherein the mask member has a deflecting unit which deflects the advancing direction of the endotracheal tube.  内部に気管内チューブを挿通可能に形成されかつシャフト部材の通孔に連通すると共に、前記気管内チューブの進行方向を偏向する湾曲形状のパイプ部材を備えている請求項1に記載の補助具。 The auxiliary tool according to claim 1, further comprising a curved pipe member which is formed in such a manner that the endotracheal tube can be inserted therethrough and which communicates with the through hole of the shaft member and which deflects the advancing direction of the endotracheal tube.  先端がシャフト部材の軸方向におけるシャフト本体の中途に位置し、前記シャフト本体の外周面から突設した突出部材を備えている請求項1から請求項3のいずれか1項に記載の補助具。 The auxiliary tool according to any one of claims 1 to 3, further comprising: a protruding member located at a midpoint of the shaft main body in the axial direction of the shaft member and having a protruding end protruding from an outer peripheral surface of the shaft main body.  突出部材が、シャフト部材の軸と開口部の中心とを通る仮想平面に対して対称となるように配置されている請求項4に記載の補助具。 The auxiliary tool according to claim 4, wherein the projecting member is arranged to be symmetrical with respect to a virtual plane passing through the axis of the shaft member and the center of the opening.  シャフト部材は、開口部の基端方向の端部から前記シャフト部材の基端方向に沿った所定距離の外周部に、マーカを有している請求項1から請求項5のいずれか1項に記載の補助具。 The shaft member has a marker on an outer peripheral portion of a predetermined distance along the proximal direction of the shaft member from an end of the opening in the proximal direction, the marker according to any one of claims 1 to 5 Auxiliary equipment described.  開口部を介する気管内チューブの送出方向が、シャフト部材の先端方向に対して4°以上30°以下となるように形成されている請求項1から請求項6のいずれか1項に記載の補助具。 The assistance according to any one of claims 1 to 6, wherein the delivery direction of the endotracheal tube through the opening is formed so as to be 4 ° or more and 30 ° or less with respect to the distal end direction of the shaft member. Equipment.  気管内チューブを喉頭を介してマウスの気管内へ案内するマウス用気管内チューブの挿管方法であって、
 請求項1から請求項7のいずれか1項に記載の補助具を、当該補助具の先端方向から前記マウスの咽頭内に挿入する第1ステップと、
 前記第1ステップの後、マスク部材を前記咽頭内における喉頭開口周囲に当接させる第2ステップと、
 前記第2ステップの後、前記補助具を介して前記気管内チューブを前記マウスの気管内に挿管する第3ステップとを備えていることを特徴とする挿管方法。
A method for intubating a mouse endotracheal tube, comprising: guiding an endotracheal tube into a trachea of a mouse via the larynx.
A first step of inserting the aid according to any one of claims 1 to 7 into the pharynx of the mouse from the distal direction of the aid;
After the first step, a second step of bringing a mask member into contact with the laryngeal opening in the pharynx;
And, after the second step, a third step of intubating the endotracheal tube into the trachea of the mouse through the auxiliary tool.
PCT/JP2019/000843 2018-01-17 2019-01-15 Auxiliary tool and method for inserting endotracheal tube for mouse using same Ceased WO2019142757A1 (en)

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JP7604415B2 (en) 2022-03-25 2024-12-23 株式会社神鋼環境ソリューション Test fish oral administration device
JP7604588B1 (en) 2023-09-22 2024-12-23 株式会社神鋼環境ソリューション Test fish oral administration device, test fish oral administration method, and method for manufacturing test fish oral administration device

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