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WO2019037071A1 - Dispositif et procédé de rétroaction et de commande à l'aide de fibres optiques dans des cathéters - Google Patents

Dispositif et procédé de rétroaction et de commande à l'aide de fibres optiques dans des cathéters Download PDF

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Publication number
WO2019037071A1
WO2019037071A1 PCT/CN2017/099004 CN2017099004W WO2019037071A1 WO 2019037071 A1 WO2019037071 A1 WO 2019037071A1 CN 2017099004 W CN2017099004 W CN 2017099004W WO 2019037071 A1 WO2019037071 A1 WO 2019037071A1
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Prior art keywords
catheter
catheters
control
feedback signals
optical fibers
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Ceased
Application number
PCT/CN2017/099004
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English (en)
Inventor
Weyland CHENG
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Individual
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Priority to PCT/CN2017/099004 priority Critical patent/WO2019037071A1/fr
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Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/065Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01DMEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D5/00Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
    • G01D5/26Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light
    • G01D5/268Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light using optical fibres
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/0499Feedforward networks
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • G06N3/09Supervised learning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046Tracking techniques
    • A61B2034/2061Tracking techniques using shape-sensors, e.g. fiber shape sensors with Bragg gratings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/30Surgical robots
    • A61B2034/301Surgical robots for introducing or steering flexible instruments inserted into the body, e.g. catheters or endoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06Measuring instruments not otherwise provided for
    • A61B2090/064Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/30Surgical robots
    • A61B34/35Surgical robots for telesurgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70Manipulators specially adapted for use in surgery
    • A61B34/71Manipulators operated by drive cable mechanisms
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02Optical fibres with cladding with or without a coating
    • G02B6/02057Optical fibres with cladding with or without a coating comprising gratings
    • G02B6/02076Refractive index modulation gratings, e.g. Bragg gratings
    • G02B6/02195Refractive index modulation gratings, e.g. Bragg gratings characterised by means for tuning the grating
    • G02B6/022Refractive index modulation gratings, e.g. Bragg gratings characterised by means for tuning the grating using mechanical stress, e.g. tuning by compression or elongation, special geometrical shapes such as "dog-bone" or taper
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00Computing arrangements using knowledge-based models
    • G06N5/04Inference or reasoning models
    • G06N5/048Fuzzy inferencing

Definitions

  • the present invention relates to generating new feedback data in a fiber optic catheter by modeling multiple feedback signals along the length of one or more optical fibers.
  • Catheters are used for a variety of diagnostic and therapeutic procedures throughout the body allowing for minimally invasive operations. It is optimal to have finer control of the catheter to minimize the procedural duration, surgical mistakes, and the skill and training requirements of the catheter operator. Remote catheters using magnetic resonance or robotic control have been introduced to allow for faster operation times. Remote systems also allow the operator to work from a separate workstation rather than by the patient’s bedside where x-ray fluoroscopy is often used to provide visual feedback images. At a distant location, operators are no longer required to wear protective heavy lead suits that often lead to chronic back injuries.
  • Robotic catheter procedures rely on internal and external feedback to provide optimal control and to reveal a clearer picture of the operating environment to the physician.
  • quality feedback is still difficult to obtain due to the size and safety requirements of intrinsic sensors and the expense, speed and efficiency of external sensors such as image analysis systems.
  • Optical fibers have been implemented in catheters, relaying in-vivo feedback signals of from the proximal end of the catheter, such as the contact tip force, oxygen saturation of the blood, fluid concentration, temperature, pressure, etc.
  • Optical fibers are optimal in that they require no electrical activity within the catheter, produce fast response signals, and can be relatively small in size.
  • Additional existing technologies in optical fibers includes the ability to receive multiple feedback signals from a single-mode fiber. For instance, using wavelength division multiplexing (WDM) , different wavelengths of light are multiplexed into a single optical fiber.
  • Fiber Bragg grating (FBG) sensors and out-coupling taps are written within the core of the fiber to generate temperature, strain, pressure, chemical or interferometric feedback from the various wavelengths. [Morey WW, Dunphy JR, Meltz G. Multiplexing fiber bragg grating sensors. 1991; 10 (4) : 351-360. ]
  • these optical fibers can be placed into the length of the catheter wall.
  • a mathematical model can be implemented to the feedback data to indirectly derive new and different data points that regular sensors cannot or have difficulty obtaining in catheter procedures.
  • the invention uses one or more optical fibers within a catheter. Preferably three to four optical fibers.
  • the optical fibers are preferably symmetrically embedded within the catheter wall.
  • Each fiber consists of multiple sensors such as stress, strain, displacement, , contact force, pressure, temperature, vibration, chemical, etc.
  • Each optical fiber may consist of only one type of sensor or a combination of these sensors. These sensors may be intrinsic or extrinsic or a combination of both.
  • the optical fiber may be a single-mode fiber or multi-mode fiber. More preferably a single-mode fiber. Multiple sensors within one optical fiber is achieved through any form of optical splitting and combining techniques such as wavelength division multiplexing, time division multiplexing or frequency division multiplexing. More preferably wavelength division multiplexing.
  • An interrogation unit is located at the proximal end of the catheter where it emits and receives the wavelength signals.
  • the signals from the optical fibers are then relayed to an operating system or microprocessor where new data is derived by implementing mathematical or statistical models such as artificial neural networks, a machine learning algorithm.
  • the newly derived data may consist of the catheter’s relative tip coordinates, the coordinate position of the entire catheter body, the tip angle or orientation, the orientation of the catheter body, the vibration of the catheter body, the momentum, speed or acceleration of the catheter’s movement, and so on.
  • the optical fiber sensor system may also be implemented in a control system to robotically control or automate the catheter.
  • the control system may use the newly derived data or it may directly use the multiple feedback signals from the fibers.
  • Common control methods may be used, such as proportional-integral-derivative (PID) control or state space models. Less common methods may also be used, such as in machine learning techniques like deep learning.
  • PID proportional-integral-derivative
  • machine learning techniques like deep learning.
  • a mass amount of data is collected, depicting the catheter in thousands of scenarios and shapes.
  • the collected data of fiber optic feedback signals and other features are processed through the machine learning algorithm to calculate a target output, which could be the distance, speed or acceleration that the robotic actuators need to actuate.
  • FIG. 1 is a depiction of the optical fibers and its sensors within the catheter
  • FIG. 2 shows a radial view of how three optical fibers may be installed within the catheter
  • FIG. 3 is a depiction of how the catheter would be shaped in various configurations to amass data for the machine learning algorithm
  • FIG. 4 is a depiction of how the sensors can placed in different patterns within the optical fibe
  • FIG. 5 is overall schematic of how the optical fiber sensor system can be used
  • FIG. 6 is a schematic of an example experimental set-up with actuators in order to collect data for a machine learning algorithm
  • One embodiment uses machine learning algorithms to derive the positional catheter tip coordinates from multiple strain sensor signals spread evenly across three symmetrically placed single-moded optical fibers 2 within the catheter 1 as in FIG. 1.
  • One of the three optical fibers also includes a temperature sensor in the event that the values of the strain sensors are temperature dependent.
  • the optical fibers run from the proximal end of the catheter to the distal end and are positioned near the outer surface of the catheter or embedded within the catheter wall, radially forming triangular points and allowing a three-dimensional platform as in FIG. 2.
  • Multiple strain sensors 3 are implemented evenly along the length of the fiber from the proximal end to the distal end. Fiber Bragg gratings 3 are used to form the strain sensors.
  • the optic signals are processed through a multiplexer and demultiplexer 5 at the proximal end 4 of the device using wavelength division multiplexing to achieve multiple signals within a single-mode fiber.
  • the feedback data is sent to a processor or operating system where it is fed to an established algorithm or mathematical model that translates the strain data to the relative coordinate position of the entire catheter body.
  • the positional coordinates of the catheter body can then be translated to a graphical display screen to give visual feedback for the physician or to a control system to robotically or remotely control the catheter through proximal actuators.
  • the multiple strain values can be directly sent to the control system where it uses these values in its control models.
  • An overall schematic of the system is displayed in FIG. 5.
  • the possible catheter control mechanisms include, but are not limited to, pull wires, smart material-actuated catheters, hydraulically driven catheters, ionic polymer-metal composites, and magnetic resonance control.
  • control system may also use different control models such as PID control, PID control with inverse kinematics, state space, fuzzy logic, deep learning or neural networks, etc.
  • Another embodiment incorporates contact force sensors at the catheter tip to account for obstructions.
  • the new shape or position of the catheter is still derived using the same data modeling methods when the tip experiences contact.
  • Another embodiment measures the vibration of the catheter caused by robotic actuation or pressure from the dynamic environment.
  • Yet another embodiment has the sensors located in different patterns throughout the optical fibers or in a specified pattern as in FIG. 4.
  • the sensors in FIG. 4 are arranged closer together near the distal end where more curves or deflection of the catheter may occur.
  • a prototype catheter as seen in FIG. 6 is automated to change shapes using external 6 and proximal 7 actuators to randomly move its body into various configurations. Examples of these configurations are seen in FIG. 3.
  • the tip 9 of the catheter may be deflected in any random direction using actuators at the proximal end 4 to pull on four pull wires 8 within the catheter.
  • the four pull wires allow for omnidirectional deflection.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Software Systems (AREA)
  • Mathematical Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Artificial Intelligence (AREA)
  • Computational Linguistics (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Computing Systems (AREA)
  • Pathology (AREA)
  • Robotics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Human Computer Interaction (AREA)
  • Endoscopes (AREA)

Abstract

L'invention concerne un cathéter (1) utilisant une ou plusieurs fibres optiques (2) pour produire de multiples signaux de rétroaction situés le long de la longueur du cathéter (1). Les signaux de rétroaction peuvent comprendre une contrainte, une pression, une température ou d'autres variables pouvant être obtenues par des fibres optiques (2). De manière séquentielle, les signaux de rétroaction sont utilisés dans un modèle analytique pour obtenir en outre de nouvelles informations de données, telles que la position de la pointe du cathéter, la forme de corps géométrique, l'orientation de la pointe, la vibration corporelle, et ainsi de suite. Les données collectées provenant du cathéter à fibre optique (1) peuvent également être utilisées pour optimiser la commande du cathéter ou pour obtenir un mouvement automatisé.
PCT/CN2017/099004 2017-08-25 2017-08-25 Dispositif et procédé de rétroaction et de commande à l'aide de fibres optiques dans des cathéters Ceased WO2019037071A1 (fr)

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PCT/CN2017/099004 WO2019037071A1 (fr) 2017-08-25 2017-08-25 Dispositif et procédé de rétroaction et de commande à l'aide de fibres optiques dans des cathéters

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Cited By (26)

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Publication number Priority date Publication date Assignee Title
CN113318324A (zh) * 2020-02-28 2021-08-31 巴德阿克塞斯系统股份有限公司 具有光学形状感测能力的导管
US20220221373A1 (en) * 2019-09-12 2022-07-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for determining the shape of an optical waveguide, and device for producing training data for a neural network
US11474310B2 (en) 2020-02-28 2022-10-18 Bard Access Systems, Inc. Optical connection systems and methods thereof
US11525670B2 (en) 2019-11-25 2022-12-13 Bard Access Systems, Inc. Shape-sensing systems with filters and methods thereof
US11622816B2 (en) 2020-06-26 2023-04-11 Bard Access Systems, Inc. Malposition detection system
US11624677B2 (en) 2020-07-10 2023-04-11 Bard Access Systems, Inc. Continuous fiber optic functionality monitoring and self-diagnostic reporting system
US11630009B2 (en) 2020-08-03 2023-04-18 Bard Access Systems, Inc. Bragg grated fiber optic fluctuation sensing and monitoring system
US11850338B2 (en) 2019-11-25 2023-12-26 Bard Access Systems, Inc. Optical tip-tracking systems and methods thereof
US11883609B2 (en) 2020-06-29 2024-01-30 Bard Access Systems, Inc. Automatic dimensional frame reference for fiber optic
US11899249B2 (en) 2020-10-13 2024-02-13 Bard Access Systems, Inc. Disinfecting covers for functional connectors of medical devices and methods thereof
US11931179B2 (en) 2020-03-30 2024-03-19 Bard Access Systems, Inc. Optical and electrical diagnostic systems and methods thereof
US11931112B2 (en) 2019-08-12 2024-03-19 Bard Access Systems, Inc. Shape-sensing system and methods for medical devices
US12064569B2 (en) 2020-09-25 2024-08-20 Bard Access Systems, Inc. Fiber optics oximetry system for detection and confirmation
US12089815B2 (en) 2022-03-17 2024-09-17 Bard Access Systems, Inc. Fiber optic medical systems and devices with atraumatic tip
US12140487B2 (en) 2017-04-07 2024-11-12 Bard Access Systems, Inc. Optical fiber-based medical device tracking and monitoring system
US12220219B2 (en) 2020-11-24 2025-02-11 Bard Access Systems, Inc. Steerable fiber optic shape sensing enabled elongated medical instrument
US12232821B2 (en) 2021-01-06 2025-02-25 Bard Access Systems, Inc. Needle guidance using fiber optic shape sensing
US12232818B2 (en) 2020-03-03 2025-02-25 Bard Access Systems, Inc. System and method for optic shape sensing and electrical signal conduction
US12285572B2 (en) 2020-11-18 2025-04-29 Bard Access Systems, Inc. Optical-fiber stylet holders and methods thereof
US12318149B2 (en) 2022-03-08 2025-06-03 Bard Access Systems, Inc. Medical shape sensing devices and systems
US12343117B2 (en) 2022-06-28 2025-07-01 Bard Access Systems, Inc. Fiber optic medical systems and methods for identifying blood vessels
US12349984B2 (en) 2022-06-29 2025-07-08 Bard Access Systems, Inc. System, method, and apparatus for improved confirm of an anatomical position of a medical instrument
US12419694B2 (en) 2021-10-25 2025-09-23 Bard Access Systems, Inc. Reference plane for medical device placement
US12426954B2 (en) 2021-01-26 2025-09-30 Bard Access Systems, Inc. Fiber optic shape sensing system associated with port placement
US12426956B2 (en) 2022-03-16 2025-09-30 Bard Access Systems, Inc. Medical system and method for monitoring medical device insertion and illumination patterns
US12446988B2 (en) 2021-09-16 2025-10-21 Bard Access Systems, Inc. Swappable high mating cycle fiber connection interface

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US12140487B2 (en) 2017-04-07 2024-11-12 Bard Access Systems, Inc. Optical fiber-based medical device tracking and monitoring system
US11931112B2 (en) 2019-08-12 2024-03-19 Bard Access Systems, Inc. Shape-sensing system and methods for medical devices
US12181369B2 (en) * 2019-09-12 2024-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for determining the shape of an optical waveguide, and device for producing training data for a neural network
US20220221373A1 (en) * 2019-09-12 2022-07-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for determining the shape of an optical waveguide, and device for producing training data for a neural network
US11850338B2 (en) 2019-11-25 2023-12-26 Bard Access Systems, Inc. Optical tip-tracking systems and methods thereof
US12403288B2 (en) 2019-11-25 2025-09-02 Bard Access Systems, Inc. Optical tip-tracking systems and methods thereof
US12130127B2 (en) 2019-11-25 2024-10-29 Bard Access Systems, Inc. Shape-sensing systems with filters and methods thereof
US11525670B2 (en) 2019-11-25 2022-12-13 Bard Access Systems, Inc. Shape-sensing systems with filters and methods thereof
US12287520B2 (en) 2020-02-28 2025-04-29 Bard Access Systems, Inc. Optical connection systems and methods thereof
US12246139B2 (en) 2020-02-28 2025-03-11 Bard Access Systems, Inc. Catheter with optic shape sensing capabilities
US11638536B1 (en) 2020-02-28 2023-05-02 Bard Access Systems, Inc. Optical connection systems and methods thereof
CN113318324A (zh) * 2020-02-28 2021-08-31 巴德阿克塞斯系统股份有限公司 具有光学形状感测能力的导管
WO2021174117A1 (fr) * 2020-02-28 2021-09-02 Bard Access Systems, Inc. Cathéter à capacités de détection de forme optique
US11474310B2 (en) 2020-02-28 2022-10-18 Bard Access Systems, Inc. Optical connection systems and methods thereof
US12232818B2 (en) 2020-03-03 2025-02-25 Bard Access Systems, Inc. System and method for optic shape sensing and electrical signal conduction
US12376794B2 (en) 2020-03-30 2025-08-05 Bard Access Systems, Inc. Optical and electrical diagnostic systems and methods thereof
US11931179B2 (en) 2020-03-30 2024-03-19 Bard Access Systems, Inc. Optical and electrical diagnostic systems and methods thereof
US12390283B2 (en) 2020-06-26 2025-08-19 Bard Access Systems, Inc. Malposition detection system
US11622816B2 (en) 2020-06-26 2023-04-11 Bard Access Systems, Inc. Malposition detection system
US11883609B2 (en) 2020-06-29 2024-01-30 Bard Access Systems, Inc. Automatic dimensional frame reference for fiber optic
US12397131B2 (en) 2020-06-29 2025-08-26 Bard Access Systems, Inc. Automatic dimensional frame reference for fiber optic
US11624677B2 (en) 2020-07-10 2023-04-11 Bard Access Systems, Inc. Continuous fiber optic functionality monitoring and self-diagnostic reporting system
US12264996B2 (en) 2020-07-10 2025-04-01 Bard Access Systems, Inc. Continuous fiber optic functionality monitoring and self-diagnostic reporting system
US11630009B2 (en) 2020-08-03 2023-04-18 Bard Access Systems, Inc. Bragg grated fiber optic fluctuation sensing and monitoring system
US12038338B2 (en) 2020-08-03 2024-07-16 Bard Access Systems, Inc. Bragg grated fiber optic fluctuation sensing and monitoring system
US12064569B2 (en) 2020-09-25 2024-08-20 Bard Access Systems, Inc. Fiber optics oximetry system for detection and confirmation
US12181720B2 (en) 2020-10-13 2024-12-31 Bard Access Systems, Inc. Disinfecting covers for functional connectors of medical devices and methods thereof
US11899249B2 (en) 2020-10-13 2024-02-13 Bard Access Systems, Inc. Disinfecting covers for functional connectors of medical devices and methods thereof
US12285572B2 (en) 2020-11-18 2025-04-29 Bard Access Systems, Inc. Optical-fiber stylet holders and methods thereof
US12220219B2 (en) 2020-11-24 2025-02-11 Bard Access Systems, Inc. Steerable fiber optic shape sensing enabled elongated medical instrument
US12232821B2 (en) 2021-01-06 2025-02-25 Bard Access Systems, Inc. Needle guidance using fiber optic shape sensing
US12426954B2 (en) 2021-01-26 2025-09-30 Bard Access Systems, Inc. Fiber optic shape sensing system associated with port placement
US12446988B2 (en) 2021-09-16 2025-10-21 Bard Access Systems, Inc. Swappable high mating cycle fiber connection interface
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