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WO2019035227A1 - Composition cosmétique de type gel - Google Patents

Composition cosmétique de type gel Download PDF

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Publication number
WO2019035227A1
WO2019035227A1 PCT/JP2018/006791 JP2018006791W WO2019035227A1 WO 2019035227 A1 WO2019035227 A1 WO 2019035227A1 JP 2018006791 W JP2018006791 W JP 2018006791W WO 2019035227 A1 WO2019035227 A1 WO 2019035227A1
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic composition
guanylate
composition
weight
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/006791
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English (en)
Japanese (ja)
Inventor
瞬 小林
貴大 鈴木
雅哉 金子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2019035227A1 publication Critical patent/WO2019035227A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a gel cosmetic composition.
  • Thickeners are used in a wide variety of products, such as various industrial products and food products.
  • thickeners are used to enhance usability and stability and to prevent dripping.
  • an anionic water-soluble polymer such as carboxyvinyl polymer is very inexpensive, highly thick, has a small amount of gelation in addition to gelation in a small amount, is excellent in transparency, has a good feeling of use with little stickiness Since it exists, it is widely used for base thickening of a wide range of compositions such as skin care and hair care.
  • Non-Patent Document 1 Patent Document 1
  • an anionic water-soluble polymer is blended in a large amount to compensate for such a decrease in viscosity, stickiness, nulliness and stickiness occur during coating, resulting in an essential drawback that the feeling in use is impaired (Patent Document 1) 2).
  • water-soluble active ingredients have been proposed for skin care and hair care cosmetics, and many of them are composed of electrolytes.
  • water-soluble active ingredients such as an amino acid which is a component of a natural moisturizing factor, sodium pyrrolidone carboxylate which is an amino acid derivative, lactic acid, a polyamino acid and the like have excellent water retention function and can moisturize the skin.
  • ascorbic acid and its derivatives, and water-soluble active ingredients such as tranexamic acid are blended in many cosmetics as a skin-whitening ingredient.
  • Non-patent Document 2 adenosine 5'-phosphate, which is a kind of nucleotide, can be used as an active ingredient (for example, a blood circulation promoting agent, a hair restorer) in cosmetics.
  • a whitening agent containing guanine has been reported (Patent Document 5).
  • nucleotides can be used as thickeners (Non-patent Document 2).
  • An object of the present invention is to develop a product using a thickener which can be used instead of an anionic polymer and which is excellent in the feeling in use.
  • a predetermined composition containing a high concentration of guanylate has desired viscosity characteristics, and moreover, when applied to a body surface such as skin, the feeling of use is excellent. Therefore, the composition is a favorite which is frequently used on a daily basis among various applications in a wide range of fields such as various industrial products and foods, and a cosmetic which has a high need for feeling in use Are considered particularly suitable for use as
  • Guanylate is considered to be a highly safe component for subjects such as humans, because it is a umami component that is consumed on a daily basis. Therefore, also from the viewpoint of safety, guanylate is suitable for use as a cosmetic.
  • guanilic acid for adjusting physical properties of cosmetics or improving the feeling of use, in particular, as a thickener capable of improving the feeling of using cosmetics regardless of the presence of an electrolyte It is not known to use guanylate.
  • the present invention is as follows. [1] containing 2.0% by weight or more of guanylate in a water-soluble medium, Gel cosmetic composition having a pH of 4.0 to 7.0. [2] The gel cosmetic composition of the above-mentioned [1], which further comprises a cationic substance. [3] The gel cosmetic composition according to the above [1] or [2], wherein the cationic substance is a metal ion. [4] The gel cosmetic composition according to any one of the above [1] to [3], wherein the concentration of guanylate is 2.0 to 4.0% by weight. [5] The gel cosmetic composition according to any one of the above [1] to [4], which has a pH of 4.5 to 6.5.
  • the gel-like cosmetic composition is (i) completely free of RNA macromolecules and / or RNA constituents other than guanylate, or (ii) RNA constituents other than guanylate
  • the gel cosmetic composition according to any one of the above [1] to [9] which is not contained in the same amount as guanyl acid.
  • the gel cosmetic composition is a moisturizing agent.
  • the cosmetic composition of the present invention containing guanyl acid at a high concentration can exhibit the effects of having desired viscosity characteristics and being excellent in feeling in use. Since guanylate is considered to be a highly safe component to subjects such as humans, it can be said that the cosmetic composition of the present invention is also excellent in terms of safety.
  • the present invention comprises greater than 2.0% by weight of guanylate in an aqueous medium.
  • a gel cosmetic composition (hereinafter simply referred to as “composition”) having a pH of 4.0 to 7.0 is provided.
  • the composition of the present invention depends on various conditions such as the type and concentration of other components (eg, physiologically acceptable salt, water-soluble medium, water-soluble active ingredient, polyol) contained in the composition of the present invention. It also varies, but contains more than 2.0% by weight of guanylate in a water-soluble medium. By having a pH of 4.0 to 7.0, sufficient gelling of the aqueous medium can be achieved. 8.
  • the composition of the present invention has a higher concentration (e.g., 4.0% by weight or more, 5.0% by weight or more, and 8.) from the viewpoint of achieving higher viscosity gelation and / or improving the feeling in use, etc. Guanylic acid can be included at 0 wt% or more, 10 wt% or more).
  • composition of the present invention is also, for example, 50% by weight or less, preferably 30% by weight or less, more preferably 25% by weight or less, still more preferably 20% by weight or less, from the viewpoint of cost reduction due to reduction of use amount. It may contain guanylate, particularly preferably at a concentration of up to 15% by weight.
  • the concentration of guanylate may be determined focusing on a specific feeling of use. For example, when focusing on the thickness at the time of application and / or the non-stickiness after application, the concentration of guanylate may be preferably 2.0 to 4.0% by weight.
  • RNA macromolecules in particular, RNA macromolecules from which a conventional composition (eg, buffer solution) is extracted, in particular, In the case where the conventional composition contains guanylate, it is assumed that the conventional composition contains guanylate as a result of the formation of guanylate by the degradation of the RNA polymer.
  • the composition of the present invention is an RNA polymer and an RNA component other than guanylate [eg, guanosine 5'-phosphate other than guanylate (guanosine 5'-diphosphate and guanosine It differs from conventional compositions containing RNA macromolecules because it does not need to contain substantially 5'-triphosphate), adenosine 5'-phosphate, cytidine 5'-phosphate, uridine 5'-phosphate). .
  • the composition of the present invention may be completely free of (i) RNA macromolecules and / or RNA components other than guanylate.
  • composition of the present invention may also contain (ii) no RNA component other than guanylate in an equivalent amount to guanylate.
  • RNA component other than guanylate in an equivalent amount to guanylate.
  • each of the RNA components other than guanylate similarly produced by degradation of RNA macromolecule eg, other than guanylate It is assumed that guanosine 5'-phosphate, adenosine 5'-phosphate, cytidine 5'-phosphate, uridine 5'-phosphate) is also included in the same amount as guanylate.
  • composition of the present invention does not need to substantially contain RNA macromolecules, it can be avoided to contain any RNA component other than guanylate in an amount equivalent to guanylate.
  • any RNA component other than guanylate eg, guanosine 5'-phosphate, adenosine 5'-phosphate
  • Cytidine 5'-phosphate, uridine 5'-phosphate, preferably all of them is, for example, 1/2 wt.% Or less, preferably 1/5 wt.
  • composition of the present invention may also contain adenines (e.g., adenine, adenosine, adenosine 5'-monophosphate, adenosine 5'-diphosphate, adenosine 5'-triphosphate, glucosyl adenosine) as RNA components other than guanylate. May not be included.
  • adenines e.g., adenine, adenosine, adenosine 5'-monophosphate, adenosine 5'-diphosphate, adenosine 5'-triphosphate, glucosyl adenosine
  • the water-soluble medium includes, for example, an aqueous solution, and a mixed solvent of an aqueous solution and an organic solvent.
  • the aqueous solution may or may not have a buffering capacity.
  • water eg, distilled water, sterile distilled water, purified water, physiological saline
  • phosphate buffer Tris-hydrochloric acid buffer
  • TE Tris-EDTA
  • carbonate buffer borax Acid buffer
  • tartaric acid buffer glycine buffer
  • citrate buffer acetate buffer
  • a hydrophilic organic solvent eg, alcohol, acetone
  • the volume of the aqueous solution is not particularly limited, but is preferably larger than the volume of the organic solvent.
  • the volume of the aqueous solution in the mixed solvent is more preferably 1.5 times or more, still more preferably 2 times or more, particularly preferably 3 times or more, 4 times or more or 5 times the volume of the organic solvent It may be more than.
  • the aqueous medium may preferably be an aqueous solution, more preferably water.
  • compositions of the invention can also be defined in terms of water content.
  • the water content in the composition of the present invention is not particularly limited as it varies depending on the types and concentrations of other components contained in the composition of the present invention and various conditions such as pH, etc. From the viewpoint of achieving higher viscosity gelation with an acid and / or improving the feeling in use, it may be, for example, 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more.
  • the water content may also be, for example, 99.5 wt% or less, preferably 99 wt% or less, more preferably 98 wt% or less. More specifically, the water content may be, for example, 50 to 99.5% by weight, preferably 60 to 99% by weight, more preferably 70 to 98% by weight.
  • the pH of the composition of the present invention is 4.0 to 7.0.
  • the composition of the present invention can sufficiently support the achievement of gelation by guanylate when the pH is in the range of 4.0 to 7.0.
  • the pH is preferably in the range of 4.5 to 6.5 from the viewpoint of achieving higher viscosity gelation and / or improving the feeling in use.
  • the composition of the present invention may further contain a cationic substance.
  • cationic substances include metal ions, arginine, lysine, histidine, ammonium ions, and quaternary amines (eg, tetraalkylamines).
  • Cationic substances can support the formation of gels by guanylate.
  • the composition of the present invention can contain one or more (e.g., two or three) cationic substances. As the cationic substance, metal ions are preferred.
  • monovalent metal ions eg, sodium ion, potassium ion
  • divalent metal ions eg, calcium ion, magnesium ion, zinc ion
  • trivalent metal ions eg, aluminum ion
  • concentration of the cationic substance may be, for example, 0.01 to 5.0, preferably 0.1 to 3.0, and more preferably 0.2 to 1.5.
  • compositions of the invention may also further comprise inosinic acid.
  • Inosinic acid can enhance the action of guanylate in combination with guanylate.
  • inosinic acid can enhance refreshing feeling. Since inosinic acid is an umami component that is consumed on a daily basis, it is considered to be a component that is highly safe for subjects such as humans. Therefore, from the viewpoint of safety as well, inosinic acid is considered to be suitable for use as a cosmetic.
  • the concentration of inosinic acid contained in the composition of the present invention is not particularly limited because it also varies depending on the types and concentrations of other components contained in the composition of the present invention and various conditions such as pH. From the viewpoint of exerting the desired action, it may be, for example, 0.05% by weight or more, preferably 0.1% by weight or more, and more preferably 0.2% by weight or more.
  • the concentration of inosinic acid is also, for example, 10% by weight or less, preferably 5% by weight or less, more preferably 2% by weight or less, and still more preferably 1% by weight or less, from the viewpoint of cost reduction due to reduction of use amount. Particularly preferably, the concentration may be 0.5% by weight or less.
  • composition of the present invention can also be specified by the relative amount of inosinic acid to guanylate in terms of exerting the desired action.
  • the weight ratio of inosine to guanylate may be, for example, in the range of 1/100 to 1/1.
  • the weight ratio may preferably be in the range of 1/50 to 1/2, more preferably 1/20 to 1/5.
  • composition of the present invention may also further comprise a polyol.
  • a polyol for example, a dihydric alcohol (eg, ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 1,4-dioxane) Butanediol, 2-butene-1,4-diol, 1,5-pentanediol, 1,2-pentanediol, isoprene glycol, hexylene glycol, diethylene glycol, dipropylene glycol), trihydric alcohol (eg, glycerin, tri) Examples include methylolpropane), tetrahydric alcohols (eg, diglycerin, pentaerythritol, 1,2,6-hexanetriol), and higher value alcohols.
  • a dihydric alcohol eg, ethylene glycol, propylene glyco
  • higher valence alcohols include sugar alcohols (eg, monosaccharide alcohols such as sorbitol and mannitol, disaccharide alcohols such as trehalose, and polysaccharide alcohols such as hyaluronic acid), and di- to tetra-valent as described above.
  • sugar alcohols eg, monosaccharide alcohols such as sorbitol and mannitol, disaccharide alcohols such as trehalose, and polysaccharide alcohols such as hyaluronic acid
  • di- to tetra-valent as described above.
  • Polymers of alcohol eg, polyglycol, polyglycerin
  • the polyhydric alcohol is preferably a di- to tetra-hydric alcohol, more preferably a di- or tri-hydric alcohol.
  • One or more types of polyhydric alcohols can be used in combination.
  • the concentration of the polyol contained in the composition of the present invention is not particularly limited as it varies depending on various conditions such as the type and concentration of the other components contained in the composition of the present invention. It may be 2% by weight or more, preferably 0.5% by weight or more, more preferably 1.0% by weight or more, still more preferably 2.0% by weight or more, and particularly preferably 5.0% by weight or more .
  • the concentration of the polyol is also, for example, 30% by weight or less, preferably 25% by weight or less, more preferably 20% by weight or less, still more preferably 15% by weight or less, particularly from the viewpoint of cost reduction due to reduction of use amount.
  • the concentration may be 10% by weight or less.
  • composition of the present invention may further contain one or more (for example, two, three or four) water-soluble active ingredients.
  • the water-soluble active ingredient used in the present invention is an active ingredient other than the above-mentioned ingredients and has any action (eg, biological action or chemical action) useful as a cosmetic.
  • the water-soluble active ingredient used in the present invention may be an electrolyte.
  • the water soluble active ingredient may be present as an ionic substance.
  • the ionic substance includes, for example, an anionic substance having an anionic moiety, a cationic substance having a cationic moiety, and a zwitterionic substance having both an anionic moiety and a cationic moiety.
  • the anionic moiety includes, for example, a carboxylate group, a phosphate group, a sulfonate group, a sulfate group and a ditorate group.
  • the cationic moiety includes an ammonium group, a phosphonium group, a guanidino group and an imidazoyl group.
  • the hydrogen atom in the ammonium group and the phosphonium group may be substituted (eg, mono-substituted, di-substituted, tri-substituted) with a group such as a hydrocarbon group (eg, alkyl).
  • the water-soluble active ingredient used in the present invention may also be a low molecular weight compound.
  • low molecular weight compound refers to a compound having a molecular weight of 1,500 or less.
  • Low molecular weight compounds are natural compounds or synthetic compounds.
  • the molecular weight of the low molecular weight compound may be 1200 or less, 1000 or less, 900 or less, 800 or less, 700 or less, 600 or less, 500 or less, 400 or less, or 300 or less.
  • the molecular weight of the low molecular weight compound may also be 30 or more, 40 or more, or 50 or more.
  • the low molecular weight compounds include, for example, amino acids, oligopeptides, vitamins, nucleosides, nucleotides, oligonucleotides, monosaccharides, oligosaccharides, lipids, fatty acids, and metabolites thereof.
  • the water soluble active ingredient used in the present invention may also be a moisturizer, a skin lightening agent, a hair restorer, or an anti-wrinkle agent.
  • the water soluble active ingredient may also be a moisturizer, a hair restorer, or an anti-wrinkle agent.
  • a combination of two or more (for example, two or three) selected from the group consisting of a moisturizer, a whitening agent, a hair restorer, and an anti-wrinkle agent (preferably, a moisturizer, a hair restorer, and an anti-wrinkle agent) Can also be used.
  • Humectants include pyrrolidone carboxylic acid, ascorbic acid 2-glucoside, polyaspartic acid, 3-acetyl-2-ethoxycarbonyl-2-methyl-1,3-thiazolidine-4-carboxylic acid, amino acids (eg, glutamic acid, asparagine) Acid, arginine, lysine, histidine, ornithine, glycine, alanine, valine, leucine, isoleucine, serine, threonine, asparagine, glutamine, cysteine, cystine, methionine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline) and mixtures thereof Glycylglycine, alanyl glutamine, dipeptide-2 (valyl tryptophan), dipeptide-4 (cysteinylglycine), dipeptide-8 (alanyl hydroxyproline), dipepti -9 (Guru Tamil lysine
  • the salts include, for example, inorganic salts and organic salts.
  • inorganic salt for example, salts of metals (eg, monovalent metals such as sodium and potassium and divalent metals such as calcium, magnesium and zinc), inorganic acids (eg, hydrogen chloride, hydrogen bromide) And salts of sulfuric acid and phosphoric acid, and salts of inorganic bases (eg, ammonia).
  • metals eg, monovalent metals such as sodium and potassium and divalent metals such as calcium, magnesium and zinc
  • inorganic acids eg, hydrogen chloride, hydrogen bromide
  • salts of sulfuric acid and phosphoric acid eg, ammonia
  • organic salt examples include salts of organic acids (eg, acetic acid, lactic acid, citric acid, tartaric acid, maleic acid, fumaric acid, monomethyl sulfuric acid, aspartic acid, and glutamic acid), and organic bases (eg, ethylene diamine, propylene diamine, Salts of ethanolamine, monoalkylethanolamine, dialkylethanolamine, diethanolamine, triethanolamine, lysine, arginine, histidine, ornithine) can be mentioned.
  • organic acids eg, acetic acid, lactic acid, citric acid, tartaric acid, maleic acid, fumaric acid, monomethyl sulfuric acid, aspartic acid, and glutamic acid
  • organic bases eg, ethylene diamine, propylene diamine, Salts of ethanolamine, monoalkylethanolamine, dialkylethanolamine, diethanolamine, triethanolamine, lysine, arginine, histidine, ornithine
  • skin lightening agents examples include vitamin C, vitamin C derivatives (eg, vitamin C glycosides such as L-ascorbic acid 2-glycoside), cysteine, tranexamic acid, hydroquinone, arbutin, ceramide, kojic acid, ellagic acid, plants Extracts as well as their salts are included.
  • vitamin C vitamin C derivatives (eg, vitamin C glycosides such as L-ascorbic acid 2-glycoside), cysteine, tranexamic acid, hydroquinone, arbutin, ceramide, kojic acid, ellagic acid, plants Extracts as well as their salts are included.
  • vitamin C vitamin C derivatives
  • cysteine eg., cysteine, tranexamic acid, hydroquinone, arbutin, ceramide, kojic acid, ellagic acid, plants Extracts as well as their salts are included.
  • One or more kinds of skin lightening agents can be used in combination.
  • a hair growth agent for example, pantothenic acid and derivatives thereof, allantoin, biotin, mononitroguaiacol, adenosine, pentadecanoic acid glyceride, dialkyl monoamine derivative, choleus extract, chlorophyll, photosensitizer, estradiol, ethynyl estradiol, pyridoxine hydrochloride, thioxolone hydrochloride, minoxidil And sulfur, organic sulfur substances, dipeptide-9 (glutamyl lysine), and salts thereof.
  • One or two or more hair growth agents can be used in combination.
  • Anti-wrinkle agents include, for example, alpha hydroxy acids, ascorbyl palmitate, ascorbyl tetrahexyl decanoate, acetyl hexapeptide-8, and salts thereof.
  • One or more anti-wrinkle agents can be used in combination.
  • the composition of the present invention may be a defined composition.
  • the term "defined” for the composition of the invention means that the ingredients and amounts contained in the composition of the invention are specified. The preparation of such defined compositions can be carried out by using known ingredients in specific amounts. Therefore, the composition of the present invention may be a material whose component or amount thereof is unknown, or a material whose component or amount may vary [eg, natural products (eg, animals such as animals, plants, fish, microorganisms, etc., Or non-living materials such as minerals) (eg, extracts, processed products) may not be included.
  • the composition of the present invention can also be defined in terms of thickness (coating feeling) at the time of coating.
  • the composition of the present invention can have the characteristic that the vibration stress at the intersection of the storage elastic modulus G 'and the loss elastic modulus G' 'is 10 Pa or more. If the vibration stress at the intersection of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′ is 10 Pa or more, a sufficient thickness (application feeling) at the time of application can be expected.
  • the vibration stress at such an intersection is preferably 15 Pa or more, more preferably 20 Pa or more, and still more preferably 25 Pa or more.
  • Such determination of the vibrational stress at the point of intersection can be performed as follows.
  • strain dependence measurement of dynamic viscoelasticity may be performed using a rheometer (AR-G2, TA Instruments) for a test sample (measuring jig: aluminum cone plate diameter 40 mm, cone Angle 2 °, measurement temperature: 35 ° C.).
  • composition of the present invention also contains other components such as thickeners, stabilizers, pH adjusters, preservatives, UV inhibitors, perfumes, dyes, etc. other than the above-mentioned thickening components (eg, guanylate). It may be.
  • thickeners stabilizers, pH adjusters, preservatives, UV inhibitors, perfumes, dyes, etc.
  • preservatives e.g. UV inhibitors, perfumes, dyes, etc.
  • UV inhibitors eg, guanylate
  • perfumes e.g, guanylate
  • thickeners other than the above-mentioned thickening component, for example, carrageenan, dextrin, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyacrylic acid, polymethacrylic acid, carboxyvinyl polymer (carbomer), ( And acrylic acid / alkyl acrylate (C10-30) copolymers, xanthan gum.
  • carrageenan dextrin
  • methylcellulose ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose
  • polyacrylic acid polymethacrylic acid
  • carboxyvinyl polymer carboxyvinyl polymer (carbomer)
  • acrylic acid / alkyl acrylate (C10-30) copolymers xanthan gum.
  • the weight ratio of the thickening agent to the above-mentioned thickening component may for example be less than 1.0, preferably less than 0.8, more preferably less than 0.4, even more preferably less than 0.2, particularly preferably less than 0.1.
  • the stabilizer examples include ascorbic acid, sodium metabisulfite and EDTA.
  • pH adjusting agents examples include aqueous solutions (buffer solutions) as described above, acidic substances such as hydrochloric acid, and basic substances such as sodium hydroxide.
  • preservatives examples include ethyl parahydroxybenzoate, sodium benzoate, salicylic acid, sorbic acid, parabens (such as methyl paraben and propyl paraben), and sodium bisulfite.
  • UV inhibitors examples include UV absorbers (eg, t-butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, oxybenzone-3), and UV scattering agents (eg, titanium oxide, zinc oxide).
  • UV absorbers eg, t-butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, oxybenzone-3
  • UV scattering agents eg, titanium oxide, zinc oxide
  • the pigment examples include organic pigments (eg, red pigment such as red No. 201, blue pigment such as blue No. 404, orange pigment such as orange No. 203, yellow pigment such as yellow No. 205, green pigment such as green No. 3) Organic lake pigments such as zirconium lake, natural pigments such as chlorophyll, and inorganic pigments (eg, white pigments such as titanium oxide, colored pigments such as iron oxide, extender pigments such as talc, pearl pigments such as mica) Be
  • organic pigments eg, red pigment such as red No. 201, blue pigment such as blue No. 404, orange pigment such as orange No. 203, yellow pigment such as yellow No. 205, green pigment such as green No.
  • Organic lake pigments such as zirconium lake
  • natural pigments such as chlorophyll
  • inorganic pigments eg, white pigments such as titanium oxide, colored pigments such as iron oxide, extender pigments such as talc, pearl pigments such as mica
  • the composition of the present invention is effective (e.g., 0.01 mg or more) at a desired site (e.g., skin, hair, body hair, scalp) of a subject (e.g., a mammal such as a human, animals such as birds, reptiles) It can be used by applying 100 g).
  • a desired site e.g., skin, hair, body hair, scalp
  • a subject e.g., a mammal such as a human, animals such as birds, reptiles
  • a desired site e.g., skin, hair, body hair, scalp
  • a subject e.g., a mammal such as a human, animals such as birds, reptiles
  • the subject is a human
  • a human who can be a user or an applicator of the composition of the present invention can enjoy the effect of feeling of use.
  • the subject is a human.
  • the condition of the subject to which the composition of the present invention is applied may be that the above site has a healthy condition, or the above site may have an abnormal condition (eg, a disease) .
  • abnormal conditions include, for example, rough skin, dryness of the skin, scale, turnover disorder, skin diseases (eg, dermatitis such as atopic dermatitis), hair loss, stains, wrinkles, freckles.
  • the composition of the present invention may further be a moisturizer, a skin-whitening agent, a hair restorer, or an anti-wrinkle agent (preferably a moisturizer, a hair-restorant, or an anti-wrinkle agent).
  • the composition of the present invention is at least two selected from the group consisting of a moisturizer, a skin lightening agent, a hair restorer, and an anti-wrinkle agent (preferably a moisturizer, a hair restorer and an anti-wrinkle agent) (eg, It may be an agent having two or three functions.
  • one or more water-soluble active ingredients are appropriately selected, and any method applicable to, for example, a desired site (eg, skin, hair, hair, scalp) according to a conventional method It can be carried out by preparing a formulation in the form of
  • the composition of the present invention may be a humectant.
  • the moisturizer of the present invention may preferably further contain a polyol as described above.
  • the humectant of the present invention may further contain, as a water-soluble active ingredient, other humectants as described above, in addition to the polyol.
  • the composition of the present invention can be used, for example, as a cosmetic for a site such as skin, hair or scalp.
  • the products for the skin include, for example, emulsions, lotions, creams, gels, essences and face masks.
  • Products for hair include, for example, hair emulsions, hair treatments, hair conditioners, shampoos, hair lotions.
  • the product for the scalp includes, for example, a hair restorer.
  • Preferred cosmetics include, for example, creams, gels, hair conditioners and hair treatments.
  • ⁇ Visual confirmation of gel-like composition The test sample prepared as described above is filled into a 50 ml glass vial and allowed to stand overnight. The next day, the glass vial was turned upside down, observed visually, and evaluated according to the following criteria. A: The gel does not fall. B: The gel maintains its shape slowly falling by gravity. C: The glass bottle drips as it is turned over. Do not maintain shape.
  • the test sample prepared as described above was subjected to strain dependence measurement of dynamic viscoelasticity using a rheometer (AR-G2, Tea Instrument) (measuring jig: aluminum cone plate diameter 40 mm) , Cone angle 2 °, measurement temperature: 35 ° C).
  • the thickness at the time of application was evaluated according to the following criteria by evaluating the vibrational stress at the intersection of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′.
  • Vibrational stress at the intersection of storage elastic modulus G 'and loss elastic modulus G'' is 25 Pa or more
  • B Vibrational stress at the intersection of storage elastic modulus G' and loss elastic modulus G '' is 10 to 25 Pa
  • C Vibrational stress at the intersection of storage elastic modulus G ′ and loss elastic modulus G ′ ′ is less than 10 Pa
  • D Storage elastic modulus G ′ does not intersect loss elastic modulus G ′ ′
  • the storage modulus G ' is an indicator of the elastic properties of the material.
  • the loss modulus G ′ ′ is an indicator of the viscous nature of the material.
  • a viscous cosmetic preparation exhibits a relationship of storage elastic modulus G '> loss elastic modulus G' 'in a range where vibrational stress is very small, and when the preparation is stressed, loss elastic modulus G' '> Storage elastic modulus G'.
  • the thickness at the time of application increases as the intersection point of the storage elastic modulus G ′ and the loss elastic modulus G ′ ′ becomes higher stress side.
  • the thickness at the time of application is an objective index of the feeling of application (the comfort when the preparation is spread), and generally, when the thickness at application is increased, the improvement of the application feeling can be expected.
  • the composition (pH 4.0 to 7.0) containing guanosine phosphate (2.0% by weight or more) in the water-soluble medium was able to gel sufficiently and was excellent in the feeling of use (Tables 1 to 3).
  • composition pH 4.0 to 7.0
  • guanosine phosphoric acid (2.0% by weight or more) in a water-soluble medium

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne un produit utilisant un épaississant, qui peut être utilisé à la place d'un polymère anionique et qui a une excellente sensation d'utilisation. Plus spécifiquement, la présente invention concerne une composition cosmétique de type gel comprenant 2,0 % en poids ou plus d'un acide guanylique dans un milieu soluble dans l'eau et ayant un pH variant de 4,0 à 7,0.
PCT/JP2018/006791 2017-08-17 2018-02-23 Composition cosmétique de type gel Ceased WO2019035227A1 (fr)

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JP2017157366 2017-08-17
JP2017-157366 2017-08-17

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WO2019035227A1 true WO2019035227A1 (fr) 2019-02-21

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021200855A1 (fr) * 2020-03-31 2021-10-07 ユニテックフーズ株式会社 Gel de protéines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001019610A (ja) * 1999-07-08 2001-01-23 Noevir Co Ltd 皮膚外用剤
JP2003095912A (ja) * 2001-09-20 2003-04-03 Noevir Co Ltd 皮膚外用剤
US20030133961A1 (en) * 2000-07-13 2003-07-17 Kazuo Nakamura Cosmetic compositions for reducing and method of using the same
JP2007308431A (ja) * 2006-05-19 2007-11-29 Kamioka Seimitsu Kagaku Kk 入浴剤
WO2012017911A1 (fr) * 2010-08-03 2012-02-09 株式会社林原生物化学研究所 Agent d'amélioration d'effet de blanchiment et son utilisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001019610A (ja) * 1999-07-08 2001-01-23 Noevir Co Ltd 皮膚外用剤
US20030133961A1 (en) * 2000-07-13 2003-07-17 Kazuo Nakamura Cosmetic compositions for reducing and method of using the same
JP2003095912A (ja) * 2001-09-20 2003-04-03 Noevir Co Ltd 皮膚外用剤
JP2007308431A (ja) * 2006-05-19 2007-11-29 Kamioka Seimitsu Kagaku Kk 入浴剤
WO2012017911A1 (fr) * 2010-08-03 2012-02-09 株式会社林原生物化学研究所 Agent d'amélioration d'effet de blanchiment et son utilisation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021200855A1 (fr) * 2020-03-31 2021-10-07 ユニテックフーズ株式会社 Gel de protéines
JPWO2021200855A1 (fr) * 2020-03-31 2021-10-07

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