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WO2019034207A3 - METHOD FOR PRODUCING A BIOCOMPATIBLE LAYER ON AN IMPLANT SURFACE - Google Patents

METHOD FOR PRODUCING A BIOCOMPATIBLE LAYER ON AN IMPLANT SURFACE Download PDF

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Publication number
WO2019034207A3
WO2019034207A3 PCT/DE2018/100708 DE2018100708W WO2019034207A3 WO 2019034207 A3 WO2019034207 A3 WO 2019034207A3 DE 2018100708 W DE2018100708 W DE 2018100708W WO 2019034207 A3 WO2019034207 A3 WO 2019034207A3
Authority
WO
WIPO (PCT)
Prior art keywords
implant
implant surface
producing
layer
biocompatible layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2018/100708
Other languages
German (de)
French (fr)
Other versions
WO2019034207A2 (en
Inventor
Albrecht Berg
Matthias Schnabelrauch
Jürgen Weisser
Andreas Pfuch
Oliver Beier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verein Zur Forderung Von Innovationen Durch Forschung Entwicklung und Technologietransfer Ev (verein Innovent Ev)
Original Assignee
Verein Zur Forderung Von Innovationen Durch Forschung Entwicklung und Technologietransfer Ev (verein Innovent Ev)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verein Zur Forderung Von Innovationen Durch Forschung Entwicklung und Technologietransfer Ev (verein Innovent Ev) filed Critical Verein Zur Forderung Von Innovationen Durch Forschung Entwicklung und Technologietransfer Ev (verein Innovent Ev)
Publication of WO2019034207A2 publication Critical patent/WO2019034207A2/en
Publication of WO2019034207A3 publication Critical patent/WO2019034207A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung einer biokompatiblen Schicht auf einer Implantatoberfläche eines Implantats bestehend aus Polyetheretherketon. Der Erfindung liegt die Aufgabe zugrunde, eine Möglichkeit anzugeben, wodurch die positiven Eigenschaften von PEEK als Implantatmaterial im Hinblick auf Einwachsverhalten, Biokompatibilität und Resorbierbarkeit der Beschichtung verbessert werden können. Erfindungsgemäß wird die Aufgabe mit einem Verfahren zur Herstellung einer biokompatiblen Schicht auf einer Implantatoberfläche eines Implantats, bestehend aus Polyetheretherketon, dadurch gelöst, dass zunächst die Implantatoberfläche durch Reduktion der Ketogruppe mit Hydroxylgruppen oder durch Auftragen einer SiOx- Beschichtung mit Hydroxylgruppen versehen wird, dann eine Kopplungsschicht mittels einer Kopplungsreagenz, ausgewählt aus der Substanzklasse der Mono-Polyisocyanate, aufgebracht wird, indem über Urethanbindungen eine Anknüpfung an die Hydroxylgruppen der Implantatoberfläche erfolgt und abschließend eine Biopolymerschicht mittels eines modifiziertes Biopolymers, ausgewählt aus den Substanzklassen der Polysaccharide und/oder Glykosaminoglykane, aufgebracht wird, indem über Urethan- und/oder Harnstoffbindungen eine Anknüpfung an die Kopplungsschicht erfolgt. Des Weiteren können die Oligoestermethacrylate sowie die Oligoesterurethanmethacrylate mittels Photoinitiatoren auf der Substratoberfläche vernetzt werden.The invention relates to a method for producing a biocompatible layer on an implant surface of an implant consisting of polyetheretherketone. The invention has for its object to provide a way whereby the positive properties of PEEK can be improved as implant material in terms of Einwachsverhalten, biocompatibility and resorbability of the coating. According to the invention, the object is achieved with a method for producing a biocompatible layer on an implant surface of an implant, consisting of polyetheretherketone, by first providing the implant surface with hydroxy groups by reduction of the keto group or by applying an SiO x coating, then a Coupling layer by means of a coupling reagent selected from the substance class of the mono-polyisocyanates is applied by attaching via urethane bonds to the hydroxyl groups of the implant surface and finally a biopolymer layer by means of a modified biopolymer selected from the substance classes of polysaccharides and / or glycosaminoglycans applied by attaching to the coupling layer via urethane and / or urea bonds. In addition, the oligoester methacrylates and the oligoester urethane methacrylates can be crosslinked by means of photoinitiators on the substrate surface.

PCT/DE2018/100708 2017-08-14 2018-08-13 METHOD FOR PRODUCING A BIOCOMPATIBLE LAYER ON AN IMPLANT SURFACE Ceased WO2019034207A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017118508.9A DE102017118508B4 (en) 2017-08-14 2017-08-14 Process for the production of a biocompatible layer on an implant surface
DE102017118508.9 2017-08-14

Publications (2)

Publication Number Publication Date
WO2019034207A2 WO2019034207A2 (en) 2019-02-21
WO2019034207A3 true WO2019034207A3 (en) 2019-04-18

Family

ID=63371449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2018/100708 Ceased WO2019034207A2 (en) 2017-08-14 2018-08-13 METHOD FOR PRODUCING A BIOCOMPATIBLE LAYER ON AN IMPLANT SURFACE

Country Status (2)

Country Link
DE (1) DE102017118508B4 (en)
WO (1) WO2019034207A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113750290A (en) * 2020-06-03 2021-12-07 深圳先进技术研究院 Polyether-ether-ketone composite implant and preparation method and application thereof
CN112869897B (en) * 2021-01-14 2022-01-25 南京医科大学附属口腔医院 A kind of zirconia implant surface treatment method
CN113398329B (en) * 2021-06-08 2023-03-14 广西民族大学 Surface modification method of polyether-ether-ketone artificial skeleton
CN114230843A (en) * 2022-01-11 2022-03-25 季华实验室 Polyether-ether-ketone surface modification method
CN114989475B (en) * 2022-05-30 2023-07-18 浙江大学 Preparation method and product application of biological functionalized surface modified polyether-ether-ketone material
CN115400267B (en) * 2022-10-10 2023-03-03 吉林大学 Preparation method and application of a polyether ether ketone composite material loaded with rosmarinic acid
CN117731832B (en) * 2024-02-19 2024-05-10 上海珀利医用材料有限公司 Medical polyether-ether-ketone composite material and preparation method and application thereof

Citations (7)

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WO2013050554A1 (en) * 2011-10-05 2013-04-11 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Carbohydrate functionalised surfaces
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WO2015103023A1 (en) * 2013-12-30 2015-07-09 Boston Scientific Scimed, Inc. Functionalized lubricious medical device coatings
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JP5280664B2 (en) 2007-10-25 2013-09-04 株式会社 資生堂 Surface modification method and surface modification material
DE102007051782B4 (en) 2007-10-30 2017-02-02 Aesculap Ag Implant for replacing a facet joint surface
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Patent Citations (7)

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DE102008036520A1 (en) * 2008-08-06 2010-02-18 Gabriel, Matthias, Dr. New hydrogel-forming polymer with an antimicrobial effect for binding on a surface, where the hydrogel-forming polymer has a quaternary ammonium group for destroying a cell membrane of a microorganism
WO2013050554A1 (en) * 2011-10-05 2013-04-11 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Carbohydrate functionalised surfaces
KR20130046283A (en) * 2011-10-27 2013-05-07 한국과학기술원 Hyaluronic acid catechol conjugate and use thereof
EP2631332A1 (en) * 2012-02-21 2013-08-28 Innovent e.V. Method for metalizing a substrate
WO2015103023A1 (en) * 2013-12-30 2015-07-09 Boston Scientific Scimed, Inc. Functionalized lubricious medical device coatings
WO2016134819A1 (en) * 2015-02-24 2016-09-01 Universität Konstanz Material for bone implants, and a method for producing same

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Also Published As

Publication number Publication date
WO2019034207A2 (en) 2019-02-21
DE102017118508A1 (en) 2019-02-14
DE102017118508B4 (en) 2021-10-28

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