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WO2019026347A1 - Dispositif de thermothérapie - Google Patents

Dispositif de thermothérapie Download PDF

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Publication number
WO2019026347A1
WO2019026347A1 PCT/JP2018/013869 JP2018013869W WO2019026347A1 WO 2019026347 A1 WO2019026347 A1 WO 2019026347A1 JP 2018013869 W JP2018013869 W JP 2018013869W WO 2019026347 A1 WO2019026347 A1 WO 2019026347A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
optical fiber
resin layer
reflected light
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/013869
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English (en)
Japanese (ja)
Inventor
深野　秀樹
周路 田上
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Okayama University NUC
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Okayama University NUC
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Filing date
Publication date
Application filed by Okayama University NUC filed Critical Okayama University NUC
Priority to JP2019533892A priority Critical patent/JP6915905B2/ja
Publication of WO2019026347A1 publication Critical patent/WO2019026347A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
    • G01K11/32—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in transmittance, scattering or luminescence in optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K5/00—Measuring temperature based on the expansion or contraction of a material
    • G01K5/48—Measuring temperature based on the expansion or contraction of a material the material being a solid
    • G01K5/50—Measuring temperature based on the expansion or contraction of a material the material being a solid arranged for free expansion or contraction
    • G01K5/52—Measuring temperature based on the expansion or contraction of a material the material being a solid arranged for free expansion or contraction with electrical conversion means for final indication

Definitions

  • the present invention relates to a thermal treatment apparatus capable of performing thermal treatment while measuring temperature.
  • Hyperthermia is known as one of cancer treatment methods. Hyperthermia utilizes the phenomenon that cancer cells have a low survival rate in the temperature range of 40 to 45 ° C. as compared to normal cells, and treatment is performed by heating the target affected area.
  • an external heating means by heat conduction such as hot air, warm water, infrared rays, etc.
  • internal heating means such as a method of heating by irradiating a microwave or an electromagnetic wave through an electrode needle and a method of irradiating by heating an ultrasonic wave are considered.
  • thermotherapy using an external heating means or in the case of hyperthermia using an internal heating means temperature measurement for confirming the heating state of the affected area is performed at the same time as heating the target affected area. Is very difficult.
  • the heating of the affected area by the heating means has to be temporarily stopped and the temperature has to be measured by a temperature sensor or the like. Therefore, the influence of the temperature drop at the temperature measurement site due to the termination of heating is likely to occur, and it has not been optimal for thermal therapy where it is important to maintain a constant temperature stably for a relatively long time.
  • heating is performed using microwaves, electromagnetic waves, ultrasonic waves, etc., so that the temperature sensor is electromagnetic or vibrational in temperature measurement during heating. Because of interference, it may not work properly, making temperature measurement more difficult.
  • a method of measuring the temperature using an optical fiber and a laser beam is known (see, for example, Patent Document 1).
  • a temperature change is detected by generating interference light and detecting a change in intensity.
  • the inventors of the present invention have invented the thermal treatment apparatus of the present invention which can perform heating treatment simultaneously with temperature measurement while conducting research and development in order to increase the intensity change of interference light. It reached.
  • the thermal treatment apparatus of the present invention comprises a light projector for emitting light in a wide wavelength band, an optical fiber device for producing first reflected light and second reflected light upon incidence of this light, and an optical fiber device.
  • a thermal treatment apparatus comprising: a light receiver for receiving interference light of the first reflected light and the second reflected light emitted, and an analyzer for analyzing a signal output from the light receiver, the optical fiber device
  • the thermotherapy device includes an optical fiber for propagating the light, a tube for surrounding the optical fiber by inserting the optical fiber, and a resin filled in the tube.
  • a resin layer formed of resin is provided on the tip side of the optical fiber, and the light emitted from the optical fiber is reflected on the tip side of the resin layer to make the second reflected light. It is caused.
  • the thermal treatment apparatus of the present invention is characterized by the following points.
  • the resin is a resin in which the length of the resin layer in the longitudinal direction of the optical fiber varies with temperature.
  • the second reflection light is condensed toward the core of the optical fiber with the tip end face of the resin layer being spherical.
  • a large diameter core body made of the same material as the core of the optical fiber and having a larger diameter than the core of the optical fiber is provided on the tip side of the optical fiber, and on the tip side of the large diameter core body Having a resin layer.
  • a curved surface for focusing the second reflected light toward the core of the optical fiber is formed at the tip of the large diameter core body.
  • the length of the resin layer from the tip of the optical fiber to the tip of the resin layer is 60 ⁇ m or less. (6) Combining laser light with light having a wide wavelength band and heating the affected area with this laser light.
  • the second reflected light of the first reflected light and the second reflected light that cause interference light is reflected by the end of the resin layer provided on the end of the optical fiber. Since the second reflected light is generated, the second reflected light can be light affected by temperature change more than the first reflected light. Therefore, since the intensity change of the interference light caused by the temperature change can be increased, the accuracy of the temperature measurement can be improved. Furthermore, it is possible to heat the affected area by the light transmitted without being reflected on the tip side of the resin layer, and it is possible to provide a thermal treatment device capable of simultaneously heating the affected area and measuring the temperature.
  • the thermal treatment apparatus of the present invention comprises a light projector for emitting light in a wide wavelength band, an optical fiber device for producing first reflected light and second reflected light upon incidence of this light, and an optical fiber device.
  • the thermal treatment device includes a light receiver that receives interference light of the emitted first reflected light and the second reflected light, and an analyzer that analyzes a signal output from the light receiver.
  • the optical fiber device comprises an optical fiber for propagating light in a wide wavelength band, a tube for surrounding the optical fiber by passing the optical fiber, and a resin filled in the tube. . Then, a resin layer formed of resin is provided on the tip side of the optical fiber, and the light emitted from the optical fiber is reflected on the tip side of the resin layer to generate the second reflected light.
  • FIG. 1 is a schematic configuration diagram of the thermal treatment device of the first embodiment.
  • the thermal treatment apparatus of the present embodiment includes a first light projector 11 that emits a laser beam used to heat an affected area, and a second light projector 12 that emits a light having a wide wavelength band used for temperature measurement.
  • the laser light emitted from the first light projector 11 and the light having a wide wavelength band emitted from the second light projector 12 are respectively incident on the wavelength demultiplexing device 15 through appropriate optical fibers.
  • the wavelength demultiplexing device 15 the laser light emitted from the first light projector 11 and the light emitted from the second light projector 12 are combined and emitted as combined light.
  • the combined light emitted from the wavelength demultiplexing device 15 is made incident on the fiber type optical circulator 13 through an appropriate optical fiber.
  • the fiber type optical circulator 13 emits the combined light incident from the wavelength demultiplexing device 15 to the optical fiber device 14.
  • the first reflected light and the second reflected light are generated, and the first reflected light and the second reflected light are made to enter the fiber type optical circulator 13. There is.
  • the first reflected light and the second reflected light that are incident from the optical fiber device 14 to the fiber type optical circulator 13 are made to enter from the fiber type optical circulator 13 to the wavelength multiplexing / demultiplexing device 15 through an appropriate optical fiber. .
  • the wavelength demultiplexing device 15 wavelength-separates only the wavelength component of the wide light of the wavelength band doctor input from the second projector 12 with respect to the light incident from the fiber type optical circulator 13 and separates the wavelength That is, interference light generated by the first reflected light and the second reflected light emitted from the optical fiber device 14 is made incident on the light receiver 16.
  • the light receiver 16 has a function of an optical spectrum analyzer, and an electrical signal proportional to the light intensity of each wavelength component based on the interference light generated by the first reflected light and the second reflected light incident thereon. Are input to the analyzer 17.
  • the analyzer 17 is a personal computer in this embodiment, and detects an output signal of light intensity for each wavelength of interference light generated by the first reflected light and the second reflected light input to the light receiver 16. The temperature change is measured by detecting the amount of wavelength shift.
  • the analyzer 17 is constituted by a personal computer, but an apparatus for executing dedicated processing may be constructed.
  • the optical fiber device 14 includes an optical fiber 14a for propagating single-mode laser light, a tube 14b for surrounding the optical fiber 14a by the insertion of the optical fiber 14a, and the tube 14b. It is composed of the resin 14c filled inside.
  • a resin layer 14c 'formed of a resin 14c is provided on the tip end side of the optical fiber 14a.
  • the resin layer 14c ' is in contact with the core of the optical fiber 14a, and a part of light incident on the resin layer 14c' is reflected by the interface between the resin layer 14c 'and the core of the optical fiber 14a.
  • the reflected light L1 of 1 is produced.
  • the light incident on the resin layer 14c ' travels in the resin layer 14c' with a spread angle due to light diffraction.
  • incident light traveling in the resin layer 14c 'with a spread angle will be referred to as "diffracted light”.
  • the optical fiber 14a uses an optical fiber having a core diameter of 8.2 ⁇ m and a cladding diameter of 125 ⁇ m
  • the tube 14b uses a Teflon (registered trademark) tube.
  • the resin 14c is a resin in which the length of the resin layer 14c 'in the longitudinal direction of the optical fiber 14a varies with temperature, and in the present embodiment, a fluorine resin is used.
  • a fluorinated acrylic resin or the like can be used other than the fluorine resin.
  • the length of the resin layer 14c ' that is, the length from the tip of the optical fiber 14a to the tip of the resin layer 14c' is about 350 ⁇ m.
  • the length of the resin layer 14c ' is referred to as "sensor length" for the convenience of description.
  • the length of the resin layer 14c' changes with temperature, so that the optical path length changes. Therefore, it is possible to generate the interference light influenced by the temperature by the first reflected light L1 which is not susceptible to the fluctuation of the optical path length due to the temperature and the second reflected light L2 which receives the fluctuation of the optical path length due to the temperature. .
  • the tip end face of the resin layer 14c 'for generating the second reflected light L2 is spherical as shown in FIG. 2 to produce the effect of a concave mirror, and the second reflected light L2 is applied to the core of the optical fiber 14a. It is focused and directed.
  • the light L2 can be significantly increased.
  • the surface tension of the resin 14c is utilized to adjust the spherical condition by adjusting the conditions for curing the resin 14c filled in the tube 14b.
  • the end face of the resin layer 14c 'that generates the second reflected light L2 is not limited to the spherical shape, and the light reflected from the tip end face of the resin layer 14c' may be light. It may be an inclined surface whose angle is adjusted to be directed to the core of the fiber 14a. In the present invention, even when configured by such an inclined surface, it is included in the spherical reflecting surface.
  • the light spectrum in the case where the tip side of the optical fiber device 14 is immersed in hot water and the temperature of the resin layer 14c 'is 36 ° C. is shown in FIG.
  • the unevenness of the light intensity due to the interference of the first reflected light L1 and the second reflected light L2 is clearly seen, and the extinction ratio, which is the size of the unevenness, is a signal with a sufficient measurement accuracy of about 3 dB.
  • the unevenness of light intensity the highest part of the convex part is called “peak”, and the lowest part of the concave part is called “dip”.
  • the tip end face of the resin layer 14c ' is not a spherical surface but a plane orthogonal to the extending direction of the core of the optical fiber 14a, the extinction ratio becomes about 1 dB or less, and the influence of noise increases. It became clear that sufficient measurement accuracy could not be obtained.
  • FIG. 4 shows the result of measuring the wavelength shift amount of the spectrum while changing the ambient temperature by immersing the tip side of the optical fiber device 14 in water and heating the water.
  • a large wavelength shift is obtained as the temperature rises.
  • the phase of the second reflected light L2 largely changes by the change of the refractive index of the resin layer 14c 'as well as the increase of the optical path length accompanying the thermal expansion of the resin layer 14c', and the interference condition changes. It is considered that this is because a change in interference wavelength appears. Therefore, it can be understood that the ambient temperature can be estimated reversely from the change of the interference wavelength, and can be used as a temperature sensor.
  • the temperature resolution was as good as about 0.06 ° C.
  • the amount of wavelength shift of the spectrum is measured as the amount of shift of a predetermined peak or dip.
  • the tip end side of the optical fiber device 14 is dipped in water, and the rise of the water temperature at the time of emitting the laser light of the incident light intensity 24.3 mW from the first light projector 11 is measured by a thermo camera. Time response of the temperature rise value What plotted with the square mark is shown in FIG.
  • the laser light is emitted from the first light projector 11 in a state where the tip side of the optical fiber device 14 is immersed in water
  • the water near the tip of the optical fiber device 14 is heated by the emitted laser light and warmed with time. It could be confirmed that Moreover, the characteristic of saturation at a temperature rise value of about 10 ° C. was obtained.
  • the thermal treatment device provided with the optical fiber device 14 of the present invention has sufficient practicability I was able to confirm that I was doing.
  • the shift amount of a predetermined peak or dip is actually measured as the wavelength shift amount of the spectrum.
  • adjacent peaks or dips are arranged at a predetermined wavelength interval, so when the shift amount becomes a value close to this wavelength interval, the peak or dip is erroneously detected. May cause a measurement error.
  • the sensor length be 60 ⁇ m or less in order not to cause measurement errors.
  • the tube 14b is made of Teflon (registered trademark), but may be made of, for example, a copolymer of tetrafluoroethylene and polyethylene having high X-ray resistance, or may be made of glass.
  • the tip end surface of the resin layer 14 c ′ for generating the second reflected light L 2 is projected from the tip of the tube 14 b, but it is shown in FIG.
  • the end of the tube 14b may be ejected more than the end end surface of the resin layer 14c '.
  • a protective layer may be provided on the outer surface of the tube 14b to form a double structure, and the protective layer may be made of Teflon (registered trademark), ethylene tetrafluoride, or the like.
  • Teflon registered trademark
  • ethylene tetrafluoride or the like.
  • a copolymer of polyethylene and the like can be used as appropriate.
  • FIG. 7 is a schematic configuration diagram of the thermal treatment device of the second embodiment.
  • the thermal treatment apparatus of the present embodiment also includes a first light projector 21 that emits a laser beam used to heat an affected area, and a second light projector 22 that emits a light having a wide wavelength band used for temperature measurement.
  • the laser beam emitted from the first light projector 21 and the light emitted from the second light projector 22 are respectively incident on the wavelength demultiplexing device 25 through appropriate optical fibers.
  • the wavelength demultiplexing device 25 combines the laser light emitted from the first light projector 21 and the light emitted from the second light projector 22 and emits the combined light.
  • the combined light emitted from the wavelength demultiplexing device 25 is made incident on the fiber type optical circulator 23 through an appropriate optical fiber.
  • the fiber type optical circulator 23 emits the combined light incident from the wavelength demultiplexing device 25 to the optical fiber device 24.
  • the first reflected light and the second reflected light are generated, and the first reflected light and the second reflected light are made to enter the fiber type optical circulator 23. There is.
  • the first reflected light and the second reflected light incident from the optical fiber device 24 to the fiber type optical circulator 23 are made incident from the fiber type optical circulator 23 to the wavelength division demultiplexer 25 via an appropriate optical fiber. .
  • the wavelength demultiplexing device 25 wavelength-separates only the wavelength component of the light having a wide wavelength band input from the second light projector 22 with respect to the light incident from the fiber type optical circulator 23, That is, interference light generated by the first reflected light and the second reflected light emitted from the optical fiber device 24 is made to be incident on the light receiver 26.
  • the light receiver 26 has the function of an optical spectrum analyzer, and is an electrical signal proportional to the light intensity of each wavelength component based on the interference light generated by the first reflected light and the second reflected light incident thereon. Are input to the analyzer 27.
  • the analyzer 27 is a personal computer in the present embodiment, and detects an output signal of light intensity for each wavelength of interference light generated by the first reflected light and the second reflected light input to the light receiver 26. The temperature change is measured by detecting the amount of wavelength shift.
  • the analyzer 27 is constituted by a personal computer, but an apparatus for executing dedicated processing may be constructed.
  • the optical fiber device 24 includes an optical fiber 24a for propagating single-mode laser light, a tube 24b for surrounding the optical fiber 24a by the insertion of the optical fiber 24a, and the tube 24b. It is comprised by resin 24c with which it filled inside, and large diameter core body 24d with which the tip side of optical fiber 24a was equipped.
  • the large diameter core body 24d is made of the same material as the core of the optical fiber 24a, and has a cylindrical shape larger in diameter than the core of the optical fiber 24a. Since the large diameter core body 24d is made of the same material as the core of the optical fiber 24a, no reflected light is generated at the interface between the core of the optical fiber 24a and the large diameter core body 24d.
  • the tip of the large diameter core body 24d forms a curved surface 24e around the central portion as a flat surface orthogonal to the extending direction of the core of the optical fiber 24a.
  • the curved surface 24e can be easily formed by heat melting the tip of the cylindrical large diameter core body 24d.
  • the inner flat surface of the curved surface 24e will be referred to as a "central plane" for convenience of explanation.
  • a resin layer 24c 'formed of a resin 24c is provided on the tip side of the large diameter core body 24d.
  • the optical fiber 24a is an optical fiber having a core diameter of 8.2 ⁇ m and a cladding diameter of 125 ⁇ m
  • the large diameter core body 24d is cylindrical with a diameter of 125 ⁇ m and a length of about 1 mm
  • the tube 24b is , Teflon (registered trademark) tube is used.
  • the resin 24c is a resin in which the length of the resin layer 24c 'in the longitudinal direction of the optical fiber 24a varies with temperature, and in the present embodiment, a fluorine resin is used.
  • a fluorinated acrylic resin or the like can be used other than the fluorine resin.
  • the length of the resin layer 24 c ′ is about 200 ⁇ m.
  • the incident light traveling straight is referred to as “straight light”, and the incident light traveling with the spread angle is referred to as “diffracted light”.
  • the first diffracted light has a small spread angle, so when it travels inside the large diameter core body 24d, The diffracted light reaches the central plane of the tip of the radial core body 24d.
  • the second diffracted light is a diffracted light that has a larger spread angle than the first diffracted light and reaches the curved surface 24e at the tip of the large diameter core body 24d when traveling inside the large diameter core body 24d.
  • the third diffracted light is a diffracted light that has a larger spread angle than the second diffracted light and reaches the side surface of the large diameter core body 24 d when traveling inside the large diameter core body 24 d.
  • the diffracted light in the following is And the first diffracted light will be described.
  • the straight-ahead light travels straight in the large diameter core body 24d, and a part of the light is reflected at the interface between the large diameter core body 24d and the resin layer 24c 'in the central plane of the tip of the large diameter core body 24d.
  • the reflected light L1 ' is produced.
  • Diffraction light also travels straight in the large diameter core body 24d and is partially reflected at the interface between the large diameter core body 24d and the resin layer 24c 'in the center plane of the tip of the large diameter core body 24d.
  • the second diffracted light and the third diffracted light light can not be expected to be light traveling toward the core of the optical fiber 24a, and therefore, does not contribute to measurement in this embodiment. There is.
  • Diffracted light transmitted without being reflected at the interface between the large diameter core body 24d and the resin layer 24c ' is incident into the resin layer 24c', and further goes straight inside the resin layer 24c 'while maintaining the spread angle.
  • the light reaches the end end face of the resin layer 24c ', and a part of the resin layer 24c' is reflected by the end end face to generate the second reflected light L2 '.
  • the tip end face of the resin layer 24c ' is a plane parallel to the central plane of the large diameter core body 24d, and the second reflected light L2' goes straight through the resin layer 24c 'while maintaining the spread angle, and the large diameter core
  • the lens effect of the curved surface 24e causes the light to travel toward the core of the optical fiber 24a.
  • the second reflected light L2 ' is light transmitted through the interface between the large diameter core body 24d and the resin layer 24c' and reflected by the end end face of the resin layer 24c ', and in particular, the large diameter
  • the light condensing action of the curved surface 24e of the core body 24d makes it possible to use more second reflected light L2 '.
  • the second reflected light L2 ' is a straight light transmitted through the interface between the large diameter core body 24d and the resin layer 24c' without being the first reflected light L1 '.
  • the light reflected by the end face of the layer 24c ' is also included.
  • the optical fiber device 24 of the present embodiment by providing the large diameter core body 24 d having the curved surface 24 e, the amount of reflected light returned to the core of the optical fiber 24 a is significantly increased. Can.
  • the curved surface 24e formed on the large diameter core body 24d is not limited to the curved surface only, and the core of the optical fiber 24a is the second reflected light L2 'that has reached the front end face of the large diameter core body 24d.
  • the curved surface 24e includes the inclined surface whose angle is adjusted in the present invention.
  • FIG. 1 An optical spectrum when the temperature of the resin layer 24c 'is set to 30 ° C. by immersing the tip side of the optical fiber device 24 of the present embodiment in hot water is shown in FIG. Irregularities in light intensity due to interference of the first reflected light L1 ′ and the second reflected light L2 ′ are clearly seen, and the extinction ratio, which is the size of the unevenness, is a signal with a sufficient measurement accuracy of 4 dB. It was By the way, in the case of using the large diameter core body 24d in which the curved surface 24e is not formed, the extinction ratio is about 1 dB or less, the influence of noise becomes large, and it is apparent that sufficient measurement accuracy can not be obtained. became.
  • FIG. 10 The result of measuring the wavelength shift of the spectrum while changing the ambient temperature by immersing the tip side of the optical fiber device 24 in water and heating the water is shown in FIG.
  • a large wavelength shift is obtained as the temperature rises. This is caused not only by an increase in the optical path length accompanying the thermal expansion of the resin layer 24c 'but also by a change in the phase of the second reflected light L2' caused by a change in the refractive index of the resin layer 24c 'and a change in interference conditions. It is considered that this is because a change in interference wavelength appears. Therefore, it can be understood that the ambient temperature can be estimated reversely from the change of the interference wavelength, and can be used as a temperature sensor. The temperature resolution was as good as about 0.06 ° C.
  • FIG. 11 shows the result of measuring the rise of the water temperature when the tip side of the optical fiber device 24 is immersed in water and the laser light of 1.48 ⁇ m wavelength is emitted from the first light projector 21 with a thermo camera.
  • the thermal treatment device provided with the optical fiber device 24 of the present invention has sufficient practicability I was able to confirm that I was doing.
  • the tube 24b is made of Teflon (registered trademark), but for example, a copolymer of tetrafluoroethylene and polyethylene having high X-ray resistance may be used, or it may be made of glass, and an appropriate material It can be used.
  • the end of the tube 24 b is made to coincide with the end end face of the resin layer 24 c ′ that generates the second reflected light L 2 ′. It may be made to project from the tip end face of resin layer 24c '.

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Abstract

L'invention concerne un dispositif de thermothérapie capable de mesurer la température et d'effectuer simultanément un traitement chauffant. Le dispositif de thermothérapie comprend un projecteur de lumière (22) pour émettre de la lumière ayant une large bande de longueur d'onde, un dispositif à fibre optique (24) pour générer une première lumière réfléchie et une seconde lumière réfléchie lorsque la lumière émise tombe sur celui-ci, un récepteur optique (26) pour recevoir la lumière d'interférence de la première lumière réfléchie et de la seconde lumière réfléchie émise par le dispositif à fibre optique (24), et un analyseur (27) pour analyser un signal émis par le récepteur optique (26). Le dispositif à fibre optique (24) a une fibre optique (24a) pour propager la lumière, un tube (24b) entourant la fibre optique (24a) suite à l'insertion de la fibre optique (24a) dans celui-ci, et une résine (24c) chargée dans le tube (24b). Une couche de résine (24c') formée de la résine (24c) est disposée sur le côté extrémité distale de la fibre optique (24a). La lumière émise par la fibre optique (24a) est réfléchie par le côté extrémité distale de la couche de résine (24c') pour générer la seconde lumière réfléchie.
PCT/JP2018/013869 2017-07-30 2018-03-30 Dispositif de thermothérapie Ceased WO2019026347A1 (fr)

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JP2019533892A JP6915905B2 (ja) 2017-07-30 2018-03-30 温熱治療器

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JP2017147302 2017-07-30
JP2017-147302 2017-07-30

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WO2019026347A1 true WO2019026347A1 (fr) 2019-02-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021065292A (ja) * 2019-10-18 2021-04-30 国立大学法人 岡山大学 温度変化検出装置及び温熱治療装置
JP2023044675A (ja) * 2021-09-17 2023-03-30 ジャイラス エーシーエムアイ インク ディー／ビー／エー オリンパス サージカル テクノロジーズ アメリカ レーザ砕石術治療領域に近接する液体媒体状態のリアルタイムでの監視

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250271A (ja) * 1987-12-04 1989-10-05 Olympus Optical Co Ltd 医用レーザ照射装置
WO2011008559A1 (fr) * 2009-06-29 2011-01-20 University Of Massachusetts Lowell Capteur de pression à fibre optique, comportant un diaphragme uniforme, et procédé de fabrication de celui-ci
JP2011191113A (ja) * 2010-03-12 2011-09-29 Tokyo Electron Ltd 温度測定用プローブ、温度測定システム及びこれを用いた温度測定方法
JP2017102107A (ja) * 2015-11-19 2017-06-08 国立大学法人 岡山大学 光ファイバ装置及びセンサシステム

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250271A (ja) * 1987-12-04 1989-10-05 Olympus Optical Co Ltd 医用レーザ照射装置
WO2011008559A1 (fr) * 2009-06-29 2011-01-20 University Of Massachusetts Lowell Capteur de pression à fibre optique, comportant un diaphragme uniforme, et procédé de fabrication de celui-ci
JP2011191113A (ja) * 2010-03-12 2011-09-29 Tokyo Electron Ltd 温度測定用プローブ、温度測定システム及びこれを用いた温度測定方法
JP2017102107A (ja) * 2015-11-19 2017-06-08 国立大学法人 岡山大学 光ファイバ装置及びセンサシステム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021065292A (ja) * 2019-10-18 2021-04-30 国立大学法人 岡山大学 温度変化検出装置及び温熱治療装置
JP7429405B2 (ja) 2019-10-18 2024-02-08 国立大学法人 岡山大学 温度変化検出装置及び温熱治療装置
JP2023044675A (ja) * 2021-09-17 2023-03-30 ジャイラス エーシーエムアイ インク ディー／ビー／エー オリンパス サージカル テクノロジーズ アメリカ レーザ砕石術治療領域に近接する液体媒体状態のリアルタイムでの監視
JP7509838B2 (ja) 2021-09-17 2024-07-02 ジャイラス エーシーエムアイ インク ディー／ビー／エー オリンパス サージカル テクノロジーズ アメリカ レーザ砕石術治療領域に近接する液体媒体状態のリアルタイムでの監視
US12478429B2 (en) 2021-09-17 2025-11-25 Gyrus Acmi, Inc. Monitoring liquid medium conditions proximate a laser lithotripsy treatment area in real time

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