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WO2019026088A1 - Formulation de soin de santé buccale et son procédé de préparation - Google Patents

Formulation de soin de santé buccale et son procédé de préparation Download PDF

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Publication number
WO2019026088A1
WO2019026088A1 PCT/IN2018/050503 IN2018050503W WO2019026088A1 WO 2019026088 A1 WO2019026088 A1 WO 2019026088A1 IN 2018050503 W IN2018050503 W IN 2018050503W WO 2019026088 A1 WO2019026088 A1 WO 2019026088A1
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Prior art keywords
composition
oral
oral care
care composition
dry
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PCT/IN2018/050503
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English (en)
Inventor
M Vijayabhanu SHETTY
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Muniyal Ayurvedic Research Centre
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Muniyal Ayurvedic Research Centre
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Publication of WO2019026088A1 publication Critical patent/WO2019026088A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)

Definitions

  • the embodiments disclosed in this specification relate to herbo-mineral composition effective in oral health care, particularly in the treatment and prevention of conditions relating to oral cavity. It also relates to the process of preparation of such composition.
  • Healthy teeth and gums are a result of good oral care.
  • Oral care compositions such as toothpastes, toothpowders, mouthwash, etc are used in order to ensure that the oral cavity is devoid of oral infections.
  • the commonly known oral problems such as gingivitis, dental caries, plaques, tartar, bad breath and sensitive teeth can be avoided by maintaining good oral hygiene.
  • dentifrices having triclosan, stannous, zinc, sodium, fluoride etc. are well known and used to combat oral problems. However, these are potentially harmful ingredients, and their extensive use may do irreversible damage to health. Hence, the use of natural herbal products may be more preferable.
  • the principal object of the embodiments disclosed herein is to provide a composition and method of Oral health care.
  • a second object of the embodiments disclosed herein is to provide a composition and method for treatment of conditions associated with Oral cavity.
  • Another object of the embodiments disclosed herein is to provide a composition and method for prevention of conditions associated with Oral cavity.
  • Another object of the embodiments disclosed herein is to provide a herbo- mineral composition used to improve oral health and a method for its preparation.
  • Fig.1(a) depicts a flowchart for the purification and potentiation of Haematite (Swarna gairika Shodhana); [0013] Fig.1(b) depicts a flowchart for the preparation of Rasanjana;
  • Fig.1(c) depicts a flowchart for the preparation of Khadira Sara
  • Fig. 2 depicts a flowchart for the preparation of fortified tablets
  • Fig. 3 represents Streptococcus mutans on mitis salivaris agar prerinse, baseline sample
  • Fig.4 represents Streptococcus mutans on mitis salivaris agar postrinse using Test drug and toothpaste with toothbrush; according to embodiments as disclosed herein.
  • the embodiments herein achieve an oral care composition and a method of its preparation.
  • Disclosed embodiments also include a method of treatment and prevention of conditions associated with oral cavity.
  • conditions associated with oral cavity would include any condition arising from poor oral care practices.
  • the conditions associated with oral cavity would include undesirable oral problems such as oral infections, oral malodor, plaque, gingivitis, periodontal diseases, teeth discoloration, teeth sensitivity, etc. Accordingly, embodiments of a method of oral health care by using the disclosed oral care composition is provided herein.
  • compositions herein provide oral care composition having a combination of selected herbs and minerals.
  • the oral care composition includes herb element and mineral element.
  • the herbal composition includes herb element, mineral element and atleast one salt.
  • the oral care composition may further include Lac from Laccifer Lacca.
  • the oral care composition may further include one or more suitable excipient.
  • the herb element includes the herbs Prunus cerasoides, Glycyrrhiza glabra, Berberis aristata, Acacia catechu and Acacia arabica or their extracts, or the active ingredients extracted from these herbs.
  • the herb element further includes at least one of the herbs selected ixa Santalum album, Vetiveria zizanoides, Rubia cordifolia, Woodfordia fruticosa, Cyperus rotundus, Cinnamomum zeylanicum, Elettaria cardamomum, Messua ferrea, Nardostachys jatamamsi, Symplocas racemosus, Curucma longa, Mimosa pudica, Acorus calamus, Aquilaria agallocha, Syzygum aromaticum, Piper cubeba, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Ficus bengalensis, Ficus glomerata, Psoralia corylifolia, Jasminum officinale and Cinnamomum camphor or their extracts, or the active ingredients extracted from these herbs.
  • the herbs selected ixa Santalum album, Vetiveria zizanoides, Rubia
  • the herb element may include a specific part of the herb (also referred as herb component) such as roots, flowers, seeds, fruits, stem, bark, resin, rhizome, whole plant, extract etc.
  • the herb element may include heartwood of Santalum album, Prunus cerasoides and Aquilaria agallocha; root of Vetiveria zizanoides, Rubia cordifolia, Cyperus rotundus, Glycyrrhiza glabra, Nardostachys jatamamsi and Acorus calamus; flowers of Woodfordia fruticosa; flower bud of Syzygum aromaticum; stamen of Messua ferrea; bark of Cinnamomum zeylanicum, Symplocas racemosus, Acacia arabica, Ficus bengalensis and Ficus glomerata; seeds of Elettaria cardamomum and Psoralia corylifolia; rhizome of
  • the herb element may also include any form of secretion, resin or discharge that may be exuded by the herb or any part of the herb.
  • the herbo -mineral composition may include other herb components such as leaf, flowers, etc. without otherwise deterring intended function of the herbo-mineral composition.
  • the herb component of the herbs, disclosed herein, maybe included in the composition in any form that is generally known in the field.
  • the herb component may be included as fresh or maybe processed to form extracts, dried, powdered, sublimated, pelleted, concentrated, etc.
  • the herb components are dried and powdered which is further incorporated into the composition.
  • the heartwood of Acacia catechu is included in the form of water extract (also referred to as Khadira sara).
  • the root of Berberis aristata is included in the form of extract (also referred to as Rasanj ana).
  • the herb component is a sublimate (Karpura) of Cinnamomum camphor.
  • the herb element includes Glycyrrhiza glabra in an amount ranging from 6 to 10 wt%, Berberis aristata in an amount ranging from 6 to 10 wt%, Acacia catechu in an amount ranging from 6 to 10 wt%, Acacia Arabica in an amount ranging from 6 to 10 wt% and Prunus cerasoides in an amount ranging from 2 to 6 wt%.
  • the herb element includes atleast one of Santalum album, Vetiveria zizanoides, Rubia cordifolia, Woodfordia fruticosa, Cyperus rotundus, Cinnamomum zeylanicum, Elettaria cardamomum, Messua ferrea, Nardostachys jatamamsi, Symplocas racemosus, Curucma longa, Mimosa pudica, Acorus calamus, Aquilaria agallocha, Syzygum aromaticum, Piper cubeba, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Ficus bengalensis, Ficus glomerata, Psoralia corylifolia, Jasminum officinale and Cinnamomum camphor in an amount of ⁇ 3 wt% each.
  • the mineral element may include Ores or Bhasmas (calcined preparations).
  • the mineral element includes Hematite (Red ochre or Swarna gairika).
  • the herbo-mineral composition it is also within the scope of claims provided herewith for the herbo-mineral composition to include, as a substitute or additionally, other similar ores or calcined preparations or minerals without otherwise deterring from the intended function of the herbo-mineral composition.
  • the mineral element includes Hematite (Red ochre or Swarna gairika) in an amount of ⁇ 3wt%.
  • the salt includes Rock salt.
  • the herbo- mineral composition disclosed herein includes rock salt in an amount of ⁇ 3 wt%.
  • the oral care composition may further include Laksha resin from Laccifer Lacca.
  • the herbo-mineral composition disclosed herein includes Laksha resin in an amount of ⁇ 3 wt%.
  • the disclosed composition in the various embodiments herein, may further include one or more suitable excipients.
  • suitable excipients include solvents, binders, lubricants, herbal carriers, oils and salts that are generally known in the art.
  • the excipient includes gum acacia.
  • the amount of herb element and mineral element that may be included in the various embodiments of the disclosed composition may be in the range of 0 to 10wt%.
  • the composition includes Glycyrrhiza glabra (6 to 10 wt%), Berberis aristata (6 to 10 wt%), Acacia catechu (6 to 10 wt%), Acacia arabica (6 to 10 wt%), Prunus cerasoides (2 to 6 wt%) and Hematite ( ⁇ 3 wt%).
  • the composition includes Glycyrrhiza glabra (6 to 10 wt%), Berberis aristata (6 to 10 wt%), Acacia catechu (6 to 10 wt%), Acacia arabica (6 to 10 wt%), Prunus cerasoides (2 to 6 wt%), Hematite ( ⁇ 3 wt%) and Laksha resin ( ⁇ 3 wt%).
  • the composition includes Glycyrrhiza glabra (6 to 10 wt%), Berberis aristata (6 to 10 wt%), Acacia catechu (6 to 10 wt%), Acacia arabica (6 to 10 wt%), Prunus cerasoides (2 to 6 wt%), Hematite ( ⁇ 3 wt%) and rock salt ( ⁇ 3 wt%).
  • the composition further includes atleast one of Santalum album, Vetiveria zizanoides, Rubia cordifolia, Woodfordia fruticosa, Cyperus rotundus, Cinnamomum zeylanicum, Elettaria cardamomum, Messua ferrea, Nardostachys jatamamsi, Symplocas racemosus, Curucma longa, Mimosa pudica, Acorus calamus, Aquilaria agallocha, Syzygum aromaticum, Piper cubeba, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Ficus bengalensis, Ficus glomerata, Psoralia corylifolia, Jasminum officinale and Cinnamomum camphor in an amount in the range of ⁇ 2 wt% .
  • the amount of gum acacia may be any amount suitable to perform the activity of an excipient.
  • the composition may include gum acacia in the range of 0 to 50 mg per 500mg of the composition, preferably 10 wt%.
  • gum acacia in the range of 0 to 50 mg per 500mg of the composition, preferably 10 wt%.
  • the herbo-mineral composition disclosed herein may be formulated in various dosage forms such that it is suitable for oral cavity.
  • the herbo-mineral composition may be in the form of tablets, pastes, gels, powder, mouth sprays, pellets, lozenges, granules, solutions, emulsions, suspensions, or any other form suitable for use.
  • the herbo- mineral composition is formulated in the form of tablets, preferably 500 mg tablets.
  • Table 1A depicts the quantities of each ingredient in a 500 mg tablet.
  • the tablet for treating/preventing/managing Renal disorders.
  • the tablet is a 500mg tablet having herb element, mineral element and an excipient as depicted in Table 1A.
  • Each 500 mg tablet includes:
  • Embodiments of the disclosed composition in tablet form were analyzed for parameters including physicochemical properties such as Tablet hardness, Loss on drying, Assay, Disintegration time, Ash value, etc and the results were noted.
  • Table 2 depicts the results of the analysis performed to determine the physicochemical properties of an embodiment of the disclosed composition.
  • the disclosed composition tablets have the characteristics as depicted in Table 2. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the present invention.
  • the method includes, levigating Swarna gairika, Khadira rasa and Rasanjana in a grinder; adding herbs/ingredients and salts into the grinder; and adding grinding decoctionwhile continuing grinding to obtain a ground mass.
  • the mixture of Swarna gairika, Khadira rasa and Rasanjana may be in semisolid form. In an embodiment, the levigation may be performed for a duration of around 3 hours.
  • the herbs/ingredients include dried and finely powdered form of heartwood of Santalum album, Prunus cerasoides and Aquilaria agallocha; root of Vetiveria zizanoides, Rubia cordifolia, Cyperus rotundus, Glycyrrhiza glabra, Nardostachys jatamamsi and Acorus calamus; flowers of Woodfordia fruticosa; flower bud of Syzygum aromaticum; stamen of Messua ferrea; bark of Cinnamomum zeylanicum, Symplocas racemosus, Acacia arabica, Ficus bengalensis and Ficus glomerata; seeds of Elettaria cardamomum and Psoralia
  • the grinding decoction is a decoction of herbs that may facilitate grinding.
  • the grinding decoction includes a decoction of atleast one herb selected from a list consisting of: Acacia catechu, Acacia arabica, Ficus bengalensis, Ficus glomerata, Sida cordifolia, Tinospora cordifolia, Plumbago zeylanica, Pluchea lanceolata, Boerhavia diffusa, Terminalia arjunaandEmbelia ribes.
  • he decoction may be obtained by any method of decocting generally known in the field.
  • the method of preparation of grinding decoction further includes, soaking the grinding herbs i.e.
  • soaking may be performed by soaking the grinding herbs in 16 parts of water overnight.
  • concentrating may be performed by boiling at high temperature, preferably about 80to 85 degree Celsius, until l/8th of the liquid remains. Concentration may be confirmed with the help of Brix meter.
  • the method of preparation may further include adding excipient to the ground mass, wherein gum acacia may be added to the ground mass by dissolving in the grinding decoction while continuing grinding for 3 hours to obtain a semisolid mass.
  • the method of preparation may further include drying at 50 degree Celsius, preferably in a hot air oven, wet granulating, punching to obtain 500mg tablets.
  • Fig. 2 depicts a flowchart for the preparation of fortified tablets.
  • Table 3 depicts the Herb ingredients required for grinding (grinding herbs) in one of the preferred embodiments.
  • red ochre The mineral red ochre used in the various embodiments herein is processed red ochre. It may be processed by any method generally known in the field. In an embodiment, red ochre is processed by levigation using cow's milk, wherein levigation is preferably performed until dryness is achieved and, the process is preferably, repeated seven times. In another embodiment, the levigated red ochre is further dried at about 50°C, powdered and sieved through 80 mesh.
  • Fig 1(a) illustrates an embodiment of the method of processing red ochre (purification and potentiation of red ochre, also referred to as Swarna gairika Shodhana)
  • Rasanjana includes extract of root of Berberis aristata.
  • Rasanjana that is used in the various embodiments herein may be prepared by methods that are generally known in the field.
  • the method of preparing Rasanjana includes decocting Berberis aristata roots, mixing the root decoction with equal amount of goat's milk, concentrating the mixture by boiling at a temperature of about 80 degree C to 85degree C to obtain a semi solid mass.
  • the semisolid mass may further be sun dried or dried in a hot air oven at about 50degreeC.
  • decocting Berberis aristata roots includes drying and coarsely powdering cleaned Berberis aristata roots; soaking powdered roots in an amount of 16 times of water, preferably overnight; and concentrating by boiling the mixture at a temperature of about 80°C to 85°C, preferably until l/8 th of the liquid remains.
  • Fig 1(b) is a flowchart illustrating a method of preparation of Rasanjana.
  • Khadira rasa includes water extract of Acacia catechu.
  • Khadira rasa that is used in the various embodiments herein may be prepared by methods that are generally known in the field.
  • the method of preparing Khadira sara includes decocting heartwood of Acacia catechu and boiling at a temperature of about 80°C to 85°C to obtain a semi solid mass. The semisolid mass may further be sun dried or dried in a hot air oven at about 50°C.
  • decocting heartwood of Acacia catechu further includes drying and coarsely powdering cleaned Acacia catechu heartwood; soaking powdered roots in an amount of 16 times of water, preferably overnight; and concentrating by boiling the mixture at a temperature of about 80°C to 85°C, preferably until 1/8* of the liquid remains.
  • Fig 1(c) is a flowchart illustrating a method of preparation of Khadira sara. Treatment
  • Disclosed herein are embodiments of a method of oral health care.
  • the embodiments disclosed herein are instrumental in improving oral health.
  • Also disclosed are embodiments of a method of treatment and prevention of conditions associated with oral cavity.
  • the method includes providing the oral cavity with a therapeutically effective amount of an embodiment of the disclosedoral care composition, wherein the oral care composition includes herb element, mineral element, and suitable excipient, wherein the herb element includes atleast one of the following herbs Santalum album, Prunus cerasoides, Vetiveria zizanoides, Rubia cordifolia, Woodfordia fruticosa, Cyperus rotundus, Glycyrrhiza glabra, Cinnamomum zeylanicum, Elettaria cardamomum, Messua ferrea, Lac (produced by laccifera lacca), Nardostachys jatamamsi, Symplocas racemosus, Curucma longa, Berberis aristata, Mimosa pudica, Acorus calamus, Aquilaria agallocha, Syzygum aromaticum, Piper cubeba, Emblica officinalis, Terminalia chebul
  • the therapeutically effective amount may vary. In an embodiment, the therapeutically effective amount is 500 to 1000 mg provided one or more times a day.
  • the embodiments of the disclosed oral care composition may be provided to the oral cavity by ways generally known in the field.
  • providing the oral care composition includes crushing and mixing one or more tablets with few drops of water to form a paste and applying the paste to the oral cavity.
  • the embodiments of the disclosed oral care composition may be applied to the oral cavity with the aid of fingers or brushing appliances such as tooth brush.
  • providing the oral care composition includes crushing and mixing one or more tablets with warm water to obtain a suspension; and rinsing the oral cavity with the obtained suspension.
  • two oral care tablets maybe crushed and mixed thoroughly with 20 ml of warm water to obtain a suspension which may further be used to rinse the oral cavity.
  • Embodiments of the disclosed oral care composition (also referred as Test drug) was further tested for efficacy as described hereunder by way of examples. The invention is further described by reference to the following examples by way of illustration only and should not be construed to limit the scope of the present invention. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the present invention.
  • Subjects A total of 40 subjects between the age group 9 and 12 years were chosen for our study based on inclusion and exclusion criteria.
  • Simplified oral hygiene index Simplified oral hygiene index (OHI-S) index as described by John C Greene and Jack R Vermillion in 1964 was followed in the study. Instruments used were mouth mirror and explorer. Teeth selected were 16, 11, 26, 36, 31, and 46.
  • Score 3 Supragingival calculus covering more than two-third of the exposed tooth surface or the continuous heavy band of subgingival calculus around the cervical portion of the tooth or both.
  • OHI-S score for each individual was calculated by the debris and calculus scores which were totaled and divided by the number of tooth surfaced scored.
  • DI-S simplified debris index
  • CI-S simplified calculus index
  • a baseline non stimulated whole salivary sample (2 ml) was collected in the morning by asking the subjects to drool passively into a sterile plastic bottle for 5 min. Subjects were informed not to eat or drink (except water) 1 h before saliva collection to minimize possible contamination from food debris and stimulation of saliva that may interfere in the results of the sample. The samples were collected in sterile bottles and were stored and carried in an ice-containing box (used as transport media). All samples were tested for the number of colony forming units (CFUs) for S. mutans using mitis salivarius bacitracin agar. [0074] Laboratory procedure: The sample was vortexed to get uniform mix of saliva and media using a Cyclo mixer.
  • Vortexed sample was streaked in duplicate on mitis salivarius bacitracin agar selective for S. mutans using an inoculation loop (standard loop with 4 mm diameter).
  • the mitis salivarius agar plates were incubated in aerobic conditions for 48 h at 37°C in an incubator. The plates were opened after 48 h.
  • the counts were made from the colonies with morphologic characteristics of S. mutans (0.5 mm raised convex undulated colonies of light blue color with rough margins, granular frosted glass appearance) on the plates using a magnifying lens and were expressed as number of CFU/ml of saliva.
  • Fig. 2 is an image illustrating Streptococcus mutans on mitis salivaris agar prerinse, baseline sample.
  • Fig. 3 is an image illustrating Streptococcus mutans on mitis salivaris agar postrinse using Test drug and toothpaste with toothbrush.
  • Salivary Pre- S. mutans count pre- and post- rinse with Colgate toothpaste and test drug. SD-Standard Deviation, Pre- S. mutans-Streptococcus mutans
  • the gingival bleeding index in Group 1, pre brushing was 1.8050 using toothpaste and Group 2 using Test drug (herbal) was 1.5450 with P value (0.008) showing significance.
  • Table 5 depicts gingival bleeding index in Group 1 and Group 2.
  • the gingival bleeding index post brushing was 1.6700 for Group 1 and 1.4300 for Group 2 with P value (0.009) showing significance.

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Abstract

L'invention concerne une formulation de soin de santé buccale et un procédé de préparation de celle-ci. La composition de soin buccal de l'invention comprend une combinaison de diverses herbes et divers minéraux, et peut être utilisée pour conserver une bonne hygiène buccale. En outre, l'invention concerne également un procédé de soin de santé buccale dans divers modes de réalisation.
PCT/IN2018/050503 2017-08-01 2018-08-01 Formulation de soin de santé buccale et son procédé de préparation Ceased WO2019026088A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022054629A1 (fr) * 2020-09-10 2022-03-17 株式会社アカシアの樹 Agent pour améliorer et maintenir la flore buccale et agent pour éliminer la plaque dentaire et empêcher la formation de tartre
CN114306151A (zh) * 2021-11-23 2022-04-12 电子科技大学中山学院 一种纳米沉香混悬液、无水沉香牙膏及其制备方法

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US20060194698A1 (en) * 2003-01-03 2006-08-31 Gwinn Kimberly D Use of herbs as a delivery system for bioactive phytochemicals
US20070110684A1 (en) * 2003-09-26 2007-05-17 Jensen Claude J Morinda Citrifolia-Based Oral Care Compositions and Methods
US9233133B2 (en) * 2010-10-25 2016-01-12 Manu Chaudhary Detoxifier herbal formulation
WO2016106072A1 (fr) * 2014-12-23 2016-06-30 Colgate-Palmolive Company Composition de soin buccal et procédé d'utilisation
US9572766B2 (en) * 2012-01-09 2017-02-21 Shiromani Gurudwara Prabandhak Committee's Guru Nanak Khalsa College Polyherbal composition for skin care

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060194698A1 (en) * 2003-01-03 2006-08-31 Gwinn Kimberly D Use of herbs as a delivery system for bioactive phytochemicals
US20070110684A1 (en) * 2003-09-26 2007-05-17 Jensen Claude J Morinda Citrifolia-Based Oral Care Compositions and Methods
US9233133B2 (en) * 2010-10-25 2016-01-12 Manu Chaudhary Detoxifier herbal formulation
US9572766B2 (en) * 2012-01-09 2017-02-21 Shiromani Gurudwara Prabandhak Committee's Guru Nanak Khalsa College Polyherbal composition for skin care
WO2016106072A1 (fr) * 2014-12-23 2016-06-30 Colgate-Palmolive Company Composition de soin buccal et procédé d'utilisation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022054629A1 (fr) * 2020-09-10 2022-03-17 株式会社アカシアの樹 Agent pour améliorer et maintenir la flore buccale et agent pour éliminer la plaque dentaire et empêcher la formation de tartre
JP2022046082A (ja) * 2020-09-10 2022-03-23 株式会社アカシアの樹 口腔内フローラ改善・維持剤、プラーク／歯垢の除去及び歯石形成予防剤
JP7448122B2 (ja) 2020-09-10 2024-03-12 株式会社アカシアの樹 口腔内フローラ改善・維持剤、プラーク／歯垢の除去及び歯石形成予防剤
CN114306151A (zh) * 2021-11-23 2022-04-12 电子科技大学中山学院 一种纳米沉香混悬液、无水沉香牙膏及其制备方法

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