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WO2019025993A3 - Medicinal composition of amaranth origin for cardiovascular treatment - Google Patents

Medicinal composition of amaranth origin for cardiovascular treatment Download PDF

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Publication number
WO2019025993A3
WO2019025993A3 PCT/IB2018/055773 IB2018055773W WO2019025993A3 WO 2019025993 A3 WO2019025993 A3 WO 2019025993A3 IB 2018055773 W IB2018055773 W IB 2018055773W WO 2019025993 A3 WO2019025993 A3 WO 2019025993A3
Authority
WO
WIPO (PCT)
Prior art keywords
amaranth
medicinal composition
origin
cardiovascular treatment
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/055773
Other languages
French (fr)
Other versions
WO2019025993A2 (en
Inventor
Benny Antony
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2019025993A2 publication Critical patent/WO2019025993A2/en
Publication of WO2019025993A3 publication Critical patent/WO2019025993A3/en
Priority to US16/752,916 priority Critical patent/US11338005B2/en
Anticipated expiration legal-status Critical
Priority to US17/718,249 priority patent/US12121556B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une composition médicinale comprenant un extrait enrichi en nitrate d'amarante pour la prévention et le traitement d'une lésion d'ischémie-reperfusion myocardique, et pour l'amélioration de la santé cardioprotectrice et de la protection cardiorénale. L'invention concerne également une méthode pour la prévention et le traitement d'une lésion d'ischémie-reperfusion myocardique, une méthode d'amélioration de la santé cardioprotectrice et de la protection cardiorénale à l'aide de la composition contenant un extrait enrichi en nitrate d'amarante.The present invention relates to a medicinal composition comprising an amaranth nitrate-enriched extract for the prevention and treatment of myocardial ischemia-reperfusion injury, and for the improvement of cardioprotective health and cardiorenal protection. The invention also relates to a method for the prevention and treatment of myocardial ischemia-reperfusion injury, a method of improving cardioprotective health and cardiorenal protection using the composition containing an enriched extract. amaranth nitrate.

PCT/IB2018/055773 2013-06-28 2018-08-01 Medicinal composition of amaranth origin for cardiovascular treatment Ceased WO2019025993A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16/752,916 US11338005B2 (en) 2013-06-28 2020-01-27 Medicinal composition of amaranth origin for cardiovascular treatment
US17/718,249 US12121556B2 (en) 2013-06-28 2022-04-11 Medicinal composition of amaranth origin for cardiovascular treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741027538 2017-08-02
IN201741027538 2017-08-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US16/710,152 Continuation-In-Part US11382943B2 (en) 2013-06-28 2019-12-11 Medicinal composition of amaranth extract origin having enriched nitrate content and a method of preparing the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/752,916 Continuation US11338005B2 (en) 2013-06-28 2020-01-27 Medicinal composition of amaranth origin for cardiovascular treatment

Publications (2)

Publication Number Publication Date
WO2019025993A2 WO2019025993A2 (en) 2019-02-07
WO2019025993A3 true WO2019025993A3 (en) 2019-03-14

Family

ID=65233582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/055773 Ceased WO2019025993A2 (en) 2013-06-28 2018-08-01 Medicinal composition of amaranth origin for cardiovascular treatment

Country Status (1)

Country Link
WO (1) WO2019025993A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120514111A (en) * 2025-05-20 2025-08-22 上海迈向胜利健康技术有限公司 Nutritional composition and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435570B1 (en) * 2008-06-13 2013-05-07 Board Of Regents, The University Of Texas System Nitrite formulations and their use as nitric oxide prodrugs
US9006493B2 (en) * 2010-07-22 2015-04-14 Kaneka Corporation Method for manufacturing a fat-soluble bioactive substance
US20160101138A1 (en) * 2013-06-28 2016-04-14 Arjuna Natural Extracts, Ltd. Medicinal Composition of Amaranth Extract Having Enriched Nitrate Content and a Method of Preparing the same
US20160228339A1 (en) * 2013-09-18 2016-08-11 Glymur B.V. Oral hygiene compositions
US20170151298A1 (en) * 2013-10-08 2017-06-01 Benny Antony Medicinal Composition of Extract of Seed of Emblica Officinalis and Method of Preparing the Same
US20170202785A1 (en) * 2005-05-30 2017-07-20 Benny Antony Formulation of Curcumin with Enhanced Bioavailability of Curcumin and method of preparation and treatment thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170202785A1 (en) * 2005-05-30 2017-07-20 Benny Antony Formulation of Curcumin with Enhanced Bioavailability of Curcumin and method of preparation and treatment thereof
US8435570B1 (en) * 2008-06-13 2013-05-07 Board Of Regents, The University Of Texas System Nitrite formulations and their use as nitric oxide prodrugs
US9006493B2 (en) * 2010-07-22 2015-04-14 Kaneka Corporation Method for manufacturing a fat-soluble bioactive substance
US20160101138A1 (en) * 2013-06-28 2016-04-14 Arjuna Natural Extracts, Ltd. Medicinal Composition of Amaranth Extract Having Enriched Nitrate Content and a Method of Preparing the same
US20160228339A1 (en) * 2013-09-18 2016-08-11 Glymur B.V. Oral hygiene compositions
US20170151298A1 (en) * 2013-10-08 2017-06-01 Benny Antony Medicinal Composition of Extract of Seed of Emblica Officinalis and Method of Preparing the Same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LUTZ, J.: "Enzymatic Hydrolysis of Whole Grain Amaranth (thesis)", 2008, pages FP - 60, XP055583417, Retrieved from the Internet <URL:https://krex.k-state.edu/dspace/bitstream/handle/2097/18691/JillLutz2014.pdf?sequence=5> [retrieved on 20181218] *

Also Published As

Publication number Publication date
WO2019025993A2 (en) 2019-02-07

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