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WO2019025857A3 - Additively manufactured functional dosage forms - Google Patents

Additively manufactured functional dosage forms Download PDF

Info

Publication number
WO2019025857A3
WO2019025857A3 PCT/IB2018/000974 IB2018000974W WO2019025857A3 WO 2019025857 A3 WO2019025857 A3 WO 2019025857A3 IB 2018000974 W IB2018000974 W IB 2018000974W WO 2019025857 A3 WO2019025857 A3 WO 2019025857A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
printed
outer shell
dosage forms
additively manufactured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/000974
Other languages
French (fr)
Other versions
WO2019025857A8 (en
WO2019025857A2 (en
Inventor
Anthony DRAGER
Mehan YAZDANIAN
Bradley MCINTURE
Haichen NIE
Paritosh WATTAMWAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of WO2019025857A2 publication Critical patent/WO2019025857A2/en
Publication of WO2019025857A3 publication Critical patent/WO2019025857A3/en
Publication of WO2019025857A8 publication Critical patent/WO2019025857A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Civil Engineering (AREA)
  • Composite Materials (AREA)
  • Structural Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

3D printed functional dosage forms, and methods for making thereof are disclosed. In one aspect of the disclosure, a dosage form is presented that includes an outer shell printed from a first material and at least one inner core containing an active pharmaceutical ingredient (API) disposed within the outer shell. The dosage form includes an opening structure extending from an outer surface of the outer shell to the at least one inner core. The dosage form may include a plurality of pH sensitive mucoadhesive projections printed from a third material and extending from the outer shell. The dosage form may include a plug printed from the second or third material within the opening structure and can include an outer cap printed over the plug from a fourth material. The dosage form also may include an internal hollow cavity such that the dosage form is buoyant in an aqueous solution.
PCT/IB2018/000974 2017-07-31 2018-07-30 Additively manufactured functional dosage forms Ceased WO2019025857A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762539303P 2017-07-31 2017-07-31
US62/539,303 2017-07-31

Publications (3)

Publication Number Publication Date
WO2019025857A2 WO2019025857A2 (en) 2019-02-07
WO2019025857A3 true WO2019025857A3 (en) 2019-03-21
WO2019025857A8 WO2019025857A8 (en) 2019-06-13

Family

ID=65233545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/000974 Ceased WO2019025857A2 (en) 2017-07-31 2018-07-30 Additively manufactured functional dosage forms

Country Status (1)

Country Link
WO (1) WO2019025857A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201813186D0 (en) * 2018-08-13 2018-09-26 Univ Central Lancashire Solid dosage from production
WO2020201319A1 (en) * 2019-04-01 2020-10-08 Université Libre de Bruxelles 3d printing compositions for modified-release pharmaceutical applications
ES2828509B2 (en) * 2019-11-26 2022-03-09 Fund Idonial COMPOSITION FOR 3D PRINTING OF SEMI-SOLID DRUGS
EP4072519B1 (en) * 2019-12-09 2025-08-06 DiHeSys Digital Health Systems GmbH Spot printing procedure and apparatus for the additive manufacturing of drug-containing pharmaceutical forms
WO2022115513A1 (en) * 2020-11-25 2022-06-02 University Of Maryland, College Park Heterogeneous microparticles, and systems and methods of making and use thereof
CN113925837A (en) * 2021-09-13 2022-01-14 四川轻化工大学 A kind of 3D printing technology is applied to the preparation method of ibuprofen
EP4385710A1 (en) * 2022-12-14 2024-06-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) An apparatus and a method for sealing an opening in a small tubular vessel
FI20236217A1 (en) * 2023-11-02 2025-05-03 Curifylabs Oy Printable dose formulation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449724A (en) * 1994-12-14 1995-09-12 Xerox Corporation Stable free radical polymerization process and thermoplastic materials produced therefrom
WO2016019078A1 (en) * 2014-07-30 2016-02-04 Tufts University Three dimensional printing of bio-ink compositions
WO2016038356A1 (en) * 2014-09-08 2016-03-17 University Of Central Lancashire Solid dosage form production
US20160354315A1 (en) * 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
WO2017158171A1 (en) * 2016-03-18 2017-09-21 Grünenthal GmbH Floating pharmaceutical dosage form

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449724A (en) * 1994-12-14 1995-09-12 Xerox Corporation Stable free radical polymerization process and thermoplastic materials produced therefrom
WO2016019078A1 (en) * 2014-07-30 2016-02-04 Tufts University Three dimensional printing of bio-ink compositions
WO2016038356A1 (en) * 2014-09-08 2016-03-17 University Of Central Lancashire Solid dosage form production
US20160354315A1 (en) * 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
WO2017158171A1 (en) * 2016-03-18 2017-09-21 Grünenthal GmbH Floating pharmaceutical dosage form

Also Published As

Publication number Publication date
WO2019025857A8 (en) 2019-06-13
WO2019025857A2 (en) 2019-02-07

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