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WO2019011801A1 - Marqueur médical implantable et dispositif destiné à l'implantation du marqueur - Google Patents

Marqueur médical implantable et dispositif destiné à l'implantation du marqueur Download PDF

Info

Publication number
WO2019011801A1
WO2019011801A1 PCT/EP2018/068360 EP2018068360W WO2019011801A1 WO 2019011801 A1 WO2019011801 A1 WO 2019011801A1 EP 2018068360 W EP2018068360 W EP 2018068360W WO 2019011801 A1 WO2019011801 A1 WO 2019011801A1
Authority
WO
WIPO (PCT)
Prior art keywords
marker
hollow cannula
stylet
hollow
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/068360
Other languages
German (de)
English (en)
Inventor
Norbert Heske
Thomas Heske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bip Biomed Instrumente & Produkte GmbH
Original Assignee
Bip Biomed Instrumente & Produkte GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bip Biomed Instrumente & Produkte GmbH filed Critical Bip Biomed Instrumente & Produkte GmbH
Publication of WO2019011801A1 publication Critical patent/WO2019011801A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00862—Material properties elastic or resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00893—Material properties pharmaceutically effective
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A61B2090/3908—Soft tissue, e.g. breast tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3987—Applicators for implanting markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3995—Multi-modality markers

Definitions

  • the invention relates to a medical, implantable marker for temporary or permanent positioning within an intracorporeal
  • Tissue area consisting of a biocompatible and by means of
  • an apparatus for implanting the marker in an animal or human tissue region comprising a hollow cannula with an obliquely inclined to the hollow cannula longitudinal axis and at a distal cutting edge,
  • Biopsy needle arrangement located intracorporeally. The marking of tissue areas, for example, in the context of a drug therapy of
  • the document DE 44 24 394 B4 discloses a wire-like marking unit which has at least two wire strands twisted together whose distal end sections are not twisted together and have arcuate barb elements projecting from the common twisting axis. For introducing the wire-like marking unit serves a
  • the twisted wire strands are made of a shape memory metal alloy, so that the distal end portions form the arcuate barb elements after leaving the hollow needle tip independently.
  • Marking unit which is intracorporeal placeable by means of a hollow needle and consists of at least two wires twisted together, with a distal
  • Wire end portion which forms a closed ring due to a material-inherent shape impression after the distal ejection through the hollow needle, which encloses at least an angle of 360 °.
  • the annularly forming distal wire form within a tissue region to be marked is advantageously characterized by negligible intracorporeal migration and improved visibility by means of conventional imaging diagnostic methods and good localization associated therewith.
  • the document DE 10 2004 055 583 A1 discloses a completely intracorporeal placeable marker in the form of a Closed ring, which can be minimally invasively placed using a delivery device consisting of a hollow needle and a longitudinally movably mounted within the hollow needle stylet.
  • the circular marker consists of
  • the hollow needle and stylet are removed extracorporeally, so that the intracorporeal markers for the person concerned does not cause any impairment.
  • micro-spheres preferably in the form of so-called “micro-spheres”, that is to say the “microspheres” consist entirely of gamma-emitting material.
  • the capsular or spherical gamma-emitting material is embedded in a so-called “soft matrix.”
  • the soft matrix is made of a non-hardenable material that remains in an amorphous state.
  • the invention is based on the object of a medical, implantable marker for temporary or permanent location within an intracorporeal tissue area, consisting of a biocompatible and means
  • a medical, implantable marker for temporary or permanent localization within an intracorporeal is characterized
  • Tissue region consisting of a biocompatible, distinguishable by sonographic diagnostics from the rest of the tissue range material characterized in that the marker is a body with a matrix consisting of an elastic material, which at least partially encloses a plurality of pore-like volumes.
  • the idea according to the invention was preceded by a large number of sonographic examinations of tissue materials into which markers made of different materials, with different shapes and sizes and different material consistencies, i. Density, material homogeneity or heterogeneity etc. have been placed. It has often been found, especially in annular markers, which are made of at least two wires twisted together, that of the rest
  • a winding structure impressed on the ring form it is necessary for a trained and experienced eye to detect the marker in the event of sonication in the ring plane in relation to the surrounding tissue area.
  • Such a marker has a matrix consisting of an elastic material, which includes closed-pore volumes, in each of which a gas, preferably air, is contained.
  • the cross-sectional shape of the marker in the direction of transmission on a sonogram or ultrasound image is distinguished in high contrast.
  • a type of ultrasound wave reflection tail is formed, which directly adjoins the marker in the direction of sound transmission and appears in high contrast.
  • These ultrasonic wave reflection signals are due to those occurring within the heterogeneous foam structure of the marker body
  • the visual conspicuity of the marker on the sonogram is significantly improved by the reflection tail described above.
  • a biocompatible elastic material preferably a biocompatible plastic, in particular one To manufacture silicone material with appropriate implant-approved certification.
  • a suitable material is, for example, under the
  • Silicone-based plastic is obtained by mixing two components and, depending on the processing, forms a foam and / or sponge structure, which in both cases has a silicone-based elastic matrix.
  • the marker according to the invention which is characterized by a heterogeneous material structure and whose consistency is characterized by the elastic matrix, has a specific weight which is roughly comparable to the specific weight of an intracorporeal tissue to be marked, whereby a marker introduced within a tissue area is permanent and remains stable at the originally placed tissue area. Migration-related changes in location, which can be permanently adjusted by specific weight differences between marker and tissue, as may be the case with markers made of metal, do not occur with the marker according to the invention.
  • the marker has an open-pored surface through which an anchoring process is conditioned by local ingrowth of the surrounding tissue into the structured or open-pore
  • Marker surface is supported or improved.
  • the elastic material of which the matrix consists additionally at least one substance admixed or be applied to the matrix surface, which has interaction properties by which the substance and thus the marker also in imaging X-ray, computed tomography or magnetic resonance method becomes visible.
  • a substance is for example an X-ray contrast agent, preferably in the form of Barium sulfate, or may have magnetic or magnetizable particles or metallic powder.
  • Marker function also serves as a carrier for a medical drug, by which within the tissue area in which the marker is implanted, a certain medical drug delivery is feasible, with respect to their
  • Concentration and time of delivery can be selected appropriately.
  • the size and shape of the marker is freely selectable and adaptable to the respective application requirements. It has proved to be particularly advantageous to form the marker spherical or in the form of an ellipsoid, especially in such body shapes in the direction of the sound behind the respective
  • Marker body form characteristic ultrasound echo signals, which represent on the sonogram, as it were a body shadow through which the
  • a hollow needle as thin as possible preferably hollow needles with diameters typically from 14 ga to 18 ga, i. 1, 6 mm to 1, 02 mm. This diameter dimension limits a maximum possible marker diameter, especially since the marker is to be placed in a compressed state within the hollow cannula for the purpose of implantation.
  • the marker is preferably a hollow cannula with an obliquely inclined to the hollow needle longitudinal axis and at a distal cutting edge, preferably in the form of cutting tips opening cutting surface, and a longitudinally movably mounted within the hollow cannula Mandrin, wherein the marker in a compressed state so within the Hollow cannula is arranged so that the marker, the hollow cannula on the distal side fluid-tight and the stylet middle or directly proximal side is brought to the compressed marker to the plant to ultimately distally move the marker by relative movement between the hollow cannula and stylet from the hollow cannula and to separate from the hollow cannula.
  • the marker assumes its original, relaxed spatial form and is completely surrounded by the surrounding tissue.
  • Tissue region provides the hollow cannula as well as the stylet ever a proximal-side attached handling agent, which is a separate or combined
  • they are attached to the stylet and to the hollow cannula
  • the transmission is designed such that an inverse movement conversion between stylet and hollow cannula is realized, i. E. in the case of a distally oriented movement of the mandrin, the hollow cannula is withdrawn proximally.
  • the transmission in this case preferably has an inverse ratio of 1: 1, i. a distal movement of the mandrin leads to a proximal movement of the hollow cannula to the same extent and vice versa.
  • FIG. 3 illustration of the Ausbringvorganges a marker with a
  • FIG. 1a shows a marker 1 in the form of a sphere, which has a large number of pore-like volumes 2, which is surrounded by a matrix 3 of elastic material, preferably of medically approved silicone material.
  • the gas-filled, preferably with air, filled pore-like volumes 2 are not necessarily the same size, but are subject to a statistical
  • the illustrated in Figure 1a embodiment has a substantially smooth spherical surface.
  • FIG. 1b shows an alternative form of the marker 1 in the form of an ellipsoid, which as it were has a foam-structure-like matrix 3, but which has regions 2 'open to the outside in some regions.
  • open-pore volumes 2 ' open-pore partial volumes 2', in the manner of a sponge structure, can join, as it were, into the depth of the matrix.
  • Embodiment over both sponge structure areas in which the individual sub-volumes 2 'are connected open-pore, as well as over
  • the markers of the invention are compressible due to the elastic matrix material 3 and have a
  • the specific gravity of the marker 1 may depend on the specific gravity of the biological
  • the marker according to the invention is distinguished by excellent
  • FIG. 2 shows a sonogram of a tissue region 4 in which the marker 1 according to the invention is implanted. It is assumed that the tissue region 4 is sonicated with an ultrasonic field propagating along the plane of the drawing from right to left. Due to the internal heterogeneous structure of the marker 1, caused for example by the internal sponge structure, a large number of ultrasonic wave reflections occurring within the marker occur
  • Ultrasonic reflection shadow 1 ' In addition to the over the surrounding tissue 4 high-contrast representing marker image 1, which is clearly recognizable to a physician, the ultrasonic wave shadow V forms another for the marker
  • the marker according to the invention causes the patient due to the intrinsic material elastic properties of the marker as a pleasant
  • FIG. 3 shows a device for implanting the marker 1, which has a hollow cannula 5 with a distal cutting edge with a cutting tip 6 and one
  • Cutting surface 7 is inclined relative to the hollow needle longitudinal axis 8.
  • a stylet 9 is longitudinally movably arranged, at the proximal end of a handling means 10 is attached.
  • the proximal end of the hollow cannula 5 has a corresponding one
  • Movement of hollow cannula 5 and / or stylet 9 provides.
  • the marker 1 is inserted into the hollow cannula 5 distally in a compressed state such that the marker 1 terminates the hollow cannula 5 at the distal end in a fluid-tight manner.
  • the stylet 9 is brought into contact with the marker 1 directly on the proximal side in order to separate the marker 1 from the hollow cannula 5 by advancing the stylet 9 distally.
  • the hollow cannula 5 with a plurality of markers 1, which are arranged serially one behind the other along the hollow cannula 5.
  • the stylet 9 would exert an axially directed delivery pressure over all the markers 1 mounted within the hollow cannula 5, in order to push the marker located at the distal end out of the hollow cannula 5.
  • FIG. 4a shows the distal region of a hollow cannula 5 equipped with a marker 1 and a mandrin 9 mounted proximally to the marker. It is assumed that the hollow cannula 5 is placed intracorporally up to a defined position x in a surrounding tissue region 4. For the purpose of spreading of the marker 1 from the hollow cannula 5, the stylet 9 moves distally forward and pushes in this way the marker 1 through the opening of the hollow cannula 5 therethrough. At the same time, the hollow cannula 5 is withdrawn proximally. In this way, the marker 1 is placed exactly at the point at which the opening of the hollow channel 5 has been placed in the image representation according to FIG. 4a.
  • FIG. 4b illustrates a situation in which the marker 1 assumes its original spherical shape, which typically has a diameter between 2 and 4 mm.
  • the illustrated in Figure 3 transmission 12 provides for manual actuation of the handling means 10 and 1 1 for an inverse motion implementation, preferably with an inverse ratio of 1: 1, ie a distal movement of the stylet 9 leads to an equal proximal movement of the hollow cannula. 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Robotics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un marqueur médical implantable, destiné à être placé temporairement ou durablement au sein d'une région tissulaire intra-corporelle, constitué d'un matériau biocompatible et pouvant être différencié de la région tissulaire restante au moyen d'un diagnostic par ultrasons. L'invention concerne en outre un dispositif destiné à l'implantation du marqueur dans une région tissulaire animale ou humaine, comprenant une canule ayant une surface tranchante inclinée obliquement par rapport à l'axe longitudinal de la canule et débouchant sur un tranchant distal, de préférence sous forme d'une pointe tranchante, et un mandrin logé au sein de la canule de manière à se déplacer longitudinalement. Le marqueur selon l'invention est caractérisé en ce qu'il est un corps comportant une matrice constituée d'un matériau élastique, qui entoure au moins en partie une pluralité de volumes en forme de pores. Afin d'implanter le marqueur, le corps est agencé au sein de la canule du dispositif dans un état comprimé, de manière à ce que le corps ferme hermétiquement la canule du côté distal. À cet effet, le mandrin est logé indirectement ou directement contre le corps, du côté proximal, de façon à venir en appui contre ce dernier, afin de séparer le corps de la canule par un mouvement relatif entre la canule et le mandrin.
PCT/EP2018/068360 2017-07-11 2018-07-06 Marqueur médical implantable et dispositif destiné à l'implantation du marqueur Ceased WO2019011801A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017211835.0A DE102017211835A1 (de) 2017-07-11 2017-07-11 Medizinischer, implantierbarer Marker und Vorrichtung zum Implantieren des Markers
DE102017211835.0 2017-07-11

Publications (1)

Publication Number Publication Date
WO2019011801A1 true WO2019011801A1 (fr) 2019-01-17

Family

ID=62842136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/068360 Ceased WO2019011801A1 (fr) 2017-07-11 2018-07-06 Marqueur médical implantable et dispositif destiné à l'implantation du marqueur

Country Status (2)

Country Link
DE (1) DE102017211835A1 (fr)
WO (1) WO2019011801A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112566544A (zh) * 2019-05-08 2021-03-26 阿特瑞克尔公司 生物组织位置定位和标记
CN114286652A (zh) * 2019-07-24 2022-04-05 Bip生物医学仪器与产品有限责任公司 能植入的标记

Citations (14)

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US20020188196A1 (en) * 1999-02-02 2002-12-12 Burbank Fred H. Cavity-filling biopsy site markers
US20040193044A1 (en) * 1999-02-02 2004-09-30 Senorx, Inc. Tissue site markers for in vivo imaging
DE4424394B4 (de) 1994-07-13 2004-12-16 Bip Acquisition Company Inc., Wilmington Vorrichtung zum Markieren von Gewebestellen
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
EP1602341A1 (fr) * 2004-06-04 2005-12-07 Inrad, Inc. Indicateur pour l'imagerie multimodale
DE102004055583A1 (de) 2004-11-18 2006-05-24 Bkh - Technotransfer Gmbh Marker für tierisches und menschliches Gewebe, insbesondere Weichteilgewebe
US20090131734A1 (en) 2006-02-16 2009-05-21 Navotek Medical Ltd. Implantable medical marker and methods of preparation thereof
US20090299298A1 (en) * 2005-06-01 2009-12-03 Novosis Ag Applicator
US20100234726A1 (en) * 1998-12-24 2010-09-16 Sirimanne D Laksen Device and method for safe location and marking of a biopsy cavity
DE102010048736A1 (de) 2010-10-16 2012-04-19 Bip Biomedizinische Instrumente Und Produkte Gmbh Marker
US20120179251A1 (en) * 1997-10-10 2012-07-12 Senorx, Inc. Tissue marking implant
US20150010470A1 (en) 2000-11-16 2015-01-08 Microspherix, LLC Flexible and/or Elastic Brachytherapy Seed or Strand
US20150245883A1 (en) * 2006-12-18 2015-09-03 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US20150297316A1 (en) * 2012-11-21 2015-10-22 Trustees Of Boston University Tissue markers and uses thereof

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Publication number Priority date Publication date Assignee Title
US20070156230A1 (en) * 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US20080015684A1 (en) * 2006-07-11 2008-01-17 Wu Patrick P Method And Apparatus For Attaching Radiopaque Markers To A Stent

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424394B4 (de) 1994-07-13 2004-12-16 Bip Acquisition Company Inc., Wilmington Vorrichtung zum Markieren von Gewebestellen
US20120179251A1 (en) * 1997-10-10 2012-07-12 Senorx, Inc. Tissue marking implant
US20100234726A1 (en) * 1998-12-24 2010-09-16 Sirimanne D Laksen Device and method for safe location and marking of a biopsy cavity
US20040193044A1 (en) * 1999-02-02 2004-09-30 Senorx, Inc. Tissue site markers for in vivo imaging
US20020188196A1 (en) * 1999-02-02 2002-12-12 Burbank Fred H. Cavity-filling biopsy site markers
US20150010470A1 (en) 2000-11-16 2015-01-08 Microspherix, LLC Flexible and/or Elastic Brachytherapy Seed or Strand
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
EP1602341A1 (fr) * 2004-06-04 2005-12-07 Inrad, Inc. Indicateur pour l'imagerie multimodale
DE102004055583A1 (de) 2004-11-18 2006-05-24 Bkh - Technotransfer Gmbh Marker für tierisches und menschliches Gewebe, insbesondere Weichteilgewebe
US20090299298A1 (en) * 2005-06-01 2009-12-03 Novosis Ag Applicator
US20090131734A1 (en) 2006-02-16 2009-05-21 Navotek Medical Ltd. Implantable medical marker and methods of preparation thereof
US20150245883A1 (en) * 2006-12-18 2015-09-03 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
DE102010048736A1 (de) 2010-10-16 2012-04-19 Bip Biomedizinische Instrumente Und Produkte Gmbh Marker
US20150297316A1 (en) * 2012-11-21 2015-10-22 Trustees Of Boston University Tissue markers and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112566544A (zh) * 2019-05-08 2021-03-26 阿特瑞克尔公司 生物组织位置定位和标记
CN114286652A (zh) * 2019-07-24 2022-04-05 Bip生物医学仪器与产品有限责任公司 能植入的标记

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