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WO2019004738A3 - Utilisation d'une composition comprenant un exosome dérivé de cellules souches adipeuses en tant que principe actif pour atténuer la dermatite - Google Patents

Utilisation d'une composition comprenant un exosome dérivé de cellules souches adipeuses en tant que principe actif pour atténuer la dermatite Download PDF

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Publication number
WO2019004738A3
WO2019004738A3 PCT/KR2018/007326 KR2018007326W WO2019004738A3 WO 2019004738 A3 WO2019004738 A3 WO 2019004738A3 KR 2018007326 W KR2018007326 W KR 2018007326W WO 2019004738 A3 WO2019004738 A3 WO 2019004738A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermatitis
composition
stem cell
effective ingredient
adipose stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/007326
Other languages
English (en)
Korean (ko)
Other versions
WO2019004738A2 (fr
Inventor
이용원
조병성
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exocobio Inc
Original Assignee
Exocobio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180018617A external-priority patent/KR20190003316A/ko
Application filed by Exocobio Inc filed Critical Exocobio Inc
Priority to JP2019571619A priority Critical patent/JP6970459B2/ja
Priority to CN201880054562.0A priority patent/CN111148520B/zh
Priority to ES18824926T priority patent/ES2978498T3/es
Priority to EP18824926.2A priority patent/EP3639832B1/fr
Publication of WO2019004738A2 publication Critical patent/WO2019004738A2/fr
Publication of WO2019004738A3 publication Critical patent/WO2019004738A3/fr
Priority to US16/727,739 priority patent/US11612621B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition contenant comme principe actif des exosomes dérivés de cellules souches adipeuses humaines pour prévenir, atténuer ou traiter la dermatite. Agissant sur de multiples cibles de cytokine à l'origine de la dermatite, une composition selon la présente invention peut être appliquée à un large spectre de dermatites attribuées à diverses causes et peut supprimer ou réduire efficacement la dermatite. De plus, la composition de la présente invention peut réduire l'évaporation de l'humidité de la couche cornée et améliorer l'hydratation de la peau pour protéger et renforcer les barrières cutanées, la dermatite pouvant ainsi être évitée, atténuée, réduite ou traitée.
PCT/KR2018/007326 2017-06-30 2018-06-28 Utilisation d'une composition comprenant un exosome dérivé de cellules souches adipeuses en tant que principe actif pour atténuer la dermatite Ceased WO2019004738A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2019571619A JP6970459B2 (ja) 2017-06-30 2018-06-28 脂肪由来幹細胞由来のエキソソームを有効成分として含む組成物の皮膚炎の改善の用途
CN201880054562.0A CN111148520B (zh) 2017-06-30 2018-06-28 包含来源于脂肪来源干细胞的外排体作为有效成分的组合物在改善皮炎中的用途
ES18824926T ES2978498T3 (es) 2017-06-30 2018-06-28 Utilización de una composición que comprende un exosoma derivado de células madre adiposas como ingrediente eficaz en el alivio de la dermatitis
EP18824926.2A EP3639832B1 (fr) 2017-06-30 2018-06-28 Utilisation d'une composition comprenant un exosome dérivé de cellules souches adipeuses en tant que principe actif pour atténuer la dermatite
US16/727,739 US11612621B2 (en) 2017-06-30 2019-12-26 Use of composition comprising exosome derived from adipose-derived stem cell as effective ingredient in ameliorating dermatitis

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR10-2017-0083506 2017-06-30
KR20170083506 2017-06-30
KR20170111179 2017-08-31
KR10-2017-0111179 2017-08-31
KR10-2018-0018617 2018-02-14
KR1020180018617A KR20190003316A (ko) 2017-06-30 2018-02-14 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도
KR10-2018-0062854 2018-05-31
KR1020180062854A KR20190003336A (ko) 2017-06-30 2018-05-31 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/727,739 Continuation US11612621B2 (en) 2017-06-30 2019-12-26 Use of composition comprising exosome derived from adipose-derived stem cell as effective ingredient in ameliorating dermatitis

Publications (2)

Publication Number Publication Date
WO2019004738A2 WO2019004738A2 (fr) 2019-01-03
WO2019004738A3 true WO2019004738A3 (fr) 2019-04-11

Family

ID=64741790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/007326 Ceased WO2019004738A2 (fr) 2017-06-30 2018-06-28 Utilisation d'une composition comprenant un exosome dérivé de cellules souches adipeuses en tant que principe actif pour atténuer la dermatite

Country Status (1)

Country Link
WO (1) WO2019004738A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102125567B1 (ko) 2019-07-02 2020-06-22 한양대학교 에리카산학협력단 식물 엑소좀의 대량 생산 방법
CA3151248A1 (fr) * 2019-09-16 2021-03-25 University Of Notre Dame Du Lac Filtration sur membrane a nanopore asymetrique (anm) basee sur la taille pour l'isolement, la concentration, et le fractionnement d'exosomes a haut rendement
CN111206016A (zh) * 2020-01-19 2020-05-29 北京再生生物科技研究院有限公司 一种预防兔耳痤疮的ADSCs条件培养基及制备方法
IL272145A (en) * 2020-01-20 2021-07-29 Stem Cell Medicine Ltd Cosmetic preparations with protein concentrate from a conditioned growth medium of stem cells from adipose tissue
CN115279387A (zh) * 2020-03-13 2022-11-01 (株)美迪合伙来音 抑制tslp及治疗或改善皮肤炎症疾病的包括含龙眼肉组合生药提取物的局部用组合物及其用途
JP6830286B1 (ja) * 2020-06-26 2021-02-17 デクソンファーマシューティカルズ株式会社 精巣機能改善剤および精巣機能改善方法
KR102572595B1 (ko) * 2020-12-02 2023-08-31 충북대학교 산학협력단 불멸화 고양이줄기세포 또는 이의 엑소좀풍부배양액을 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122087A (ko) * 2008-02-22 2010-11-19 에이전시 포 사이언스, 테크놀로지 앤드 리서치 중간엽 줄기세포 입자
US20150125950A1 (en) * 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
KR20160026234A (ko) * 2014-08-29 2016-03-09 (주)코스메디션 다기능 경피 흡수 미용기기 및 피부 미용방법
WO2017023690A1 (fr) * 2015-07-31 2017-02-09 Exoceuticals, Inc. Compositions d'exosomes et méthodes pour la préparation et l'utilisation de ces derniers pour la régulation et le conditionnement de la peau et des cheveux

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122087A (ko) * 2008-02-22 2010-11-19 에이전시 포 사이언스, 테크놀로지 앤드 리서치 중간엽 줄기세포 입자
US20150125950A1 (en) * 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
KR20160026234A (ko) * 2014-08-29 2016-03-09 (주)코스메디션 다기능 경피 흡수 미용기기 및 피부 미용방법
WO2017023690A1 (fr) * 2015-07-31 2017-02-09 Exoceuticals, Inc. Compositions d'exosomes et méthodes pour la préparation et l'utilisation de ces derniers pour la régulation et le conditionnement de la peau et des cheveux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOSCH, STEFFI ET AL.: "Trehalose Prevents Aggregation of Exosomes and Cryodamage", SCIENTIFIC REPORTS, vol. 6, 2016, pages 1 - 11, XP055500173, DOI: doi:10.1038/srep36162 *
See also references of EP3639832A4 *

Also Published As

Publication number Publication date
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