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WO2019090441A1 - Sonde respiratoire pour procédés chirurgicaux radioguidés - Google Patents

Sonde respiratoire pour procédés chirurgicaux radioguidés Download PDF

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Publication number
WO2019090441A1
WO2019090441A1 PCT/CL2017/050062 CL2017050062W WO2019090441A1 WO 2019090441 A1 WO2019090441 A1 WO 2019090441A1 CL 2017050062 W CL2017050062 W CL 2017050062W WO 2019090441 A1 WO2019090441 A1 WO 2019090441A1
Authority
WO
WIPO (PCT)
Prior art keywords
head
probe according
intraoperative probe
connector
intraoperative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CL2017/050062
Other languages
English (en)
Spanish (es)
Inventor
Francisco Javier MARTÍNEZ CATALDO
Luis Angelo GONZÁLEZ OYARZÚN
Sergey KULESHOV TRAVNIKOVA
Matías Patricio LIZ VARGAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Tecnica Federico Santa Maria USM
Original Assignee
Universidad Tecnica Federico Santa Maria USM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Tecnica Federico Santa Maria USM filed Critical Universidad Tecnica Federico Santa Maria USM
Priority to PE2020000476A priority Critical patent/PE20210541A1/es
Priority to MX2020004832A priority patent/MX2020004832A/es
Priority to PCT/CL2017/050062 priority patent/WO2019090441A1/fr
Priority to ARP180103287A priority patent/AR113494A1/es
Publication of WO2019090441A1 publication Critical patent/WO2019090441A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/20—Measuring radiation intensity with scintillation detectors
    • G01T1/202—Measuring radiation intensity with scintillation detectors the detector being a crystal

Definitions

  • the present invention pertains to the field of medical devices, in particular to intraoperative probes for radio-guided procedures such as laparoscopic, thoracic surgeries, radioguided tumorectomies, localization of radioactive seeds and identification of sentinel lymph node, among others either by means of robotic surgery or manual.
  • detection probes to locate tumors and / or sentinel lymph nodes by means of radionuclides that are injected to the patient prior to surgery, such as occurs in radioguided parathyroid surgery or in the identification of lymph node. sentinel.
  • the probes used for these purposes generally consist of an apparatus that has a handle for manipulation by the doctor and with a head which is inserted into the patient for example through surgical inserts.
  • the device has a detector to locate and measure the radiation emitted by the tissue that concentrates the elongated radionuc, information that is sent in real time either wired or wirelessly to a receiving equipment for viewing by the doctor.
  • US 2016170035 proposes a manual nuclear acquisition probe that includes a gamma photon sensor.
  • the gamma photon sensor includes an integrated collimator to collimate or directing gamma photons and a scintillator to convert received gamma photons into optical photons, which are then picked up and detected by a photodiode optically coupled to the scintillator.
  • the probe allows the operator to change the parameters of nuclear uptake from inside the sterile surgical field by means of a switch to facilitate the identification of a target area during a guided radio surgical procedure.
  • WO 2017069658 discloses a gamma probe comprising a power source, a detector module arranged in a collimator and an electronic module, all arranged inside a housing.
  • the electronic module comprises a comparator, a controller, display units, a unit for controlling the temperature of the detector module, a power control unit and an activation unit.
  • the comparator is designed to have a variable threshold in which it is activated by a signal from the detector module.
  • the controller is adapted to process and analyze an analog signal received from the comparator and to visualize the data obtained in the display units.
  • a drawback with the aforementioned prior art devices is that they do not propose a solution that allows their use in different radio-guided procedures through the use of different techniques such as laparoscopic, thoracic surgeries, radioguided tumorectomies, localization of radioactive seeds and ganglion identification. sentinel, among others either by means of robotic or manual surgery.
  • This is how different surgical procedures may require different types of radiopharmaceuticals and therefore the use of different probes and collimators. For example, when radiation is detected over relatively large areas, large tip probes are preferred, since they exhibit higher detection sensitivity than small tip probes. This allows the surgeon to more quickly identify the focus that contains the radiation.
  • US 2016170035 discloses a probe with a body that houses a power source and a data acquisition system that includes a preamp unit, a signal discriminator unit and controls to allow the improvement of signals.
  • the probe body also houses at least one output device for measuring (audibly and / or visually) the detected radiation and a wireless transmitter that transmits the data from the probe to a receiver.
  • a hinged head is attached to the body of the probe, which is configured to mechanically receive the interchangeable tips.
  • a tip with a scintillator coupled to a diode PIN to be used in certain cases and for low energy drugs use for example a solid state detector such as CdZnTe among others. That is, it aims to exchange tips with different detectors, depending on the surgery and drug to be used.
  • a solid state detector such as CdZnTe among others.
  • using different detectors in the same device is primarily important in constructive terms and second, the fact that only vary the tip of the device represents a limitation in the case of surgeries or procedures where heads are required.
  • different shapes and dimensions as for example in the case of laparoscopic surgery or in open surgery, where the dimensions and shape of the body of the probe that is required in each of these procedures is different and could not be done only by exchanging the tip of this.
  • the scintillators used by them are of low density and atomic number, which is disadvantageous, since the glass must be of greater dimension with respect to one of greater density, to achieve the same efficiency of absorption. As a result, a larger diameter probe is obtained and therefore more invasive.
  • the scintillators that are usually used are the CsI ⁇ Na) or CsI (Ti), which also have a high decay constant, which limits the temporal response of the probe.
  • the present proposed invention consists of an intraoperative probe and a system for radio-guided surgical procedures.
  • the probe is composed of a handle and a series of interchangeable heads selected according to the type of procedure or surgery to be performed and / or drug to be used.
  • Said handle consists mainly of a housing that houses inside a button on and off the probe, a power supply or battery to supply the power to the probe and an electronic card or PCB to control the signals of the various elements of the probe and its operation.
  • the head of the probe mainly comprises a head connector for coupling to the handle and a head body comprising inside an electrical circuit and a detector composed of an inorganic scintillator that when excited by gamma photons emits photons in the visible range, which are detected by a silicon photomultiplier (SiPM) optically coupled to the inorganic scintillator. Then the signals generated by the SiPM are sent to the handle and processed on the electronic card.
  • SiPM silicon photomultiplier
  • the handle of the proposed probe comprises an electro-mechanical connector that allows it to be connected to the different interchangeable heads and control their operation by means of a detection system and common operating principle independent of the head, which avoids having to use different types of probes for each surgical procedure to be performed, generating significant savings taking into account the high cost that these devices generally have.
  • the head of the present invention is advantageously configured in such a way that its body comprises three sub-sections, which grants different degrees of freedom in the design of interchangeable heads of any size, thickness, rigidity and shape according to the requirements of the procedure Surgical to perform.
  • a head of a total length between 300 and 400 mm with a width in the entire section of the head body between 10 and 12 mm.
  • the electrical circuit and the detector can be configured in the sub-section corresponding to the tip of the head.
  • the sub-sections of the body may be a single piece of sterilizable medical material of at least Ha class, such as surgical steel, titanium and others.
  • the probe of the present invention also supports the design of flexible heads for use for example in robotic surgeries.
  • the central sub-section of the head body must be flexible to grant a greater degree of freedom at the moment of manipulate the tip of the head by attaching a laparoscopic clip.
  • the electric circuit can be included in the sub-section closest to the handle so that the tip of the body has a shorter length and therefore is more maneuverable.
  • the central sub-section of the head body it can be connected and sealed to the other sub-sections at least complying with IP65 standard.
  • the probe admits a head that can include an internal collimator to allow to vary the field of vision of the probe depending on the radioguided surgery to be performed.
  • the thickness of the internal collimator and therefore the total width of the tip of the head will depend on the radiopharmaceutical to be detected, so that the higher the energy level of the radiopharmaceutical, the greater the thickness of the collimator must be to attenuate the gamma rays. any direction other than the field of vision.
  • the probe accepts a head configured for connection with interchangeable external collimators. This allows the surgeon to select different collimators that connect to the tip of the head to vary the sensitivity parameter in [cps / MBq] v / s the spatial resolution in [mm] or vice versa, depending on the radiosurgery to be performed.
  • the material of the internal collimator or that of the inner layer of the interchangeable collimator can be tungsten, gold or other dense material.
  • a dense material is used to collimate the gamma rays in the smallest possible thickness and prevent the width of the head from increasing, so that the radioguided surgery is less invasive.
  • the detector of the probe has been designed so that the crystal is one of the following group: LYSO (Ce), LaBr_3 (Ce), LaCl_3 (Ce) or any other that has a decay time at most a few tens of [ns], a high number of photons emitted by [KeV] absorbed and a high density together with a high effective atomic number.
  • LYSO Ce
  • LaBr_3 Ce
  • LaCl_3 LaCl_3
  • a SiPM is coupled, obtaining a detector with clear technical advantages regarding the configuration typical of the state of the art where a scintillator CsI (Na) or CsI (Ti) coupled to a silicon photodiode is used.
  • a first technical advantage associated with the foregoing has to do with the type of crystal used in the detector of the present invention, which has a decay constant at least 25 times faster than the crystals of state-of-the-art devices mentioned above, which translates into a better temporary response when radioguiding the doctor in surgery.
  • a second technical advantage is associated to the type of photon detector that is used in the present invention and corresponds to a silicon photomultiplier (SiPM) which is capable of detecting up to 1 photon, in addition to having a high gain of the order of 10. 6 Said photon detector is much superior to the traditional photodiode PIN which has unity gain and therefore requires an electrical circuit that includes a preamplifier of greater design complexity given the poor signal-to-noise ratio of the analog pulse to the output of said detector.
  • SiPM silicon photomultiplier
  • the fact that the scintillator used in the present invention has a high density together with a high effective atomic number, increases the probability that a gamma ray will be absorbed and therefore obtain a greater sensitivity in [cps / MBq ], ensuring the good performance of the medical device in radioguided surgery.
  • the electronic circuit located in the handle of the probe comprises three sub-modules.
  • a first sub-module comprising the microcontroller is configured to process different signals such as reading the temperature of the power supply, reading the voltage and current of the power supply to monitor the state of the battery during surgery and the reading of the temperature of the silicon photomultiplier (SiPM) included in the head.
  • SiPM silicon photomultiplier
  • Another important function of the electronic card is to guarantee the correct operation at different operating temperatures of the detector located in the head. To achieve this, it is It is necessary to correct the gain of the silicon photomultiplier, making an adjustment of the high voltage output of the second sub-module depending on the temperature of the photomultiplier that has been measured with a temperature sensor located in the head. Said voltage reading is processed in the first sub-module comparing with the operating voltage of the SiPM depending on the temperature reading and thus it is possible to keep constant the gain of any analogous pulse coming from the photomultiplier, as can be seen in the curve horizontal of Figure 6.
  • a third sub-module of the electronic card includes a buffer amplifier module together with an analog pulse discriminator.
  • the buffer amplifier allows to measure the analogue pulse that comes from the SiPM contained in the head detector, to obtain an energy spectrum that allows to calibrate the comparison levels of the discriminator and thus guarantee that the digital pulses after the discriminator that go towards a GPIO port of the microcontroller be of the energy window of interest, in an operating range between 5 and 40 [C °].
  • a system for guided radio procedures is proposed by means of the probe proposed in conjunction with a user interface that can be implemented in a fixed or portable device such as a Tablet, a Smart phone , a Laptop, etc.
  • the user interface wirelessly receives the data transmitted from the probe and is configured according to the head and radiopharmaceutical used to provide the physician either visually and / or auditorily the count per second of the photons detected by the probe during the surgical procedure.
  • the system allows the doctor to advantageously diagnose in real time the structures and areas of the patient with radionuclide concentration, as well as to know at all times the state of the probe, such as the battery charge, among others.
  • FIG. 1 illustrates a diagram of a cross section of the handle of the probe, according to the present invention.
  • FIG. 2 shows a diagram of a cross section of the interchangeable head of the probe of the present invention, with different degrees of freedom in the design.
  • FIG. 3 represents the tip of the interchangeable head next to a possible interchangeable collimator, according to the present invention.
  • FIG. 4 shows a schematic of the user interface when used in conjunction with the probe of the present invention.
  • Figure 1 represents the handle of the probe of the present invention, whose housing 1 is preferably made of medical grade plastic or other material for medical use of Ha class.
  • the housing 1 has an on / off button 5, a source of feeding 3, an electronic card 6 or PCB and a temperature sensor of handle 7.
  • the on / off button 5 of the probe is located on the surface of the handle, preferably at the rear and can be a switch or a normally open or closed pushbutton which in both cases may or may not include a led indicating the status on and off of the medical device.
  • the power supply 3 is preferably an autonomous battery located inside the back of the handle, which is responsible for feeding both the electronics of the handle on the electronic card 6 and the electronics of any of the interchangeable heads.
  • the power supply 3 comprises a single battery of +3 VDC at a charging current of a few tens of [mA], although other voltages can also be used.
  • the battery may or may not be rechargeable.
  • the handle temperature sensor 7 is preferably located on one side of the power supply 3. Said sensor corresponds to a resistance temperature sensor which can be an NTC or PTC thermistor welded on the electronic card 6 and included as a safety system in the event of overheating of the power supply 3 or battery.
  • the signals of the power supply 3 and of the on / off button 5 are connected to the electronic card 6 through connections 8.1 and 8.2 respectively, which can be cables, a flexible PCB or pogo pins.
  • connections 8.1 and 8.2 can be cables, a flexible PCB or pogo pins.
  • the signals that transmit these connections are the one of the button and the LED signal of the on / off button 5, the voltage of the power supply 3, the earth and the signal of the handle temperature sensor 7, among others.
  • the handle is configured to exchange different heads such as that of Figure 2 by means of an electro-mechanical handle connector (2, 4) comprising an electrical connector of handle 2 and a mechanical connector of handle 4.
  • Said electro-mechanical connector of handle (2, 4) preferably has IP65 protection or higher so that the handle can be sterilized and decontaminated after surgery.
  • the mechanical connector 4 can be a threaded element, a magnet or any other mechanical fastening system that allows connection with any of the heads that are represented in Figure 2. Said connection is produced thanks to the fact that at one end of the head there is a mechanical head connector 4.1 configured to be coupled to the mechanical connector of handle 4 and an electrical connector of head 2.1 configured to be respectively coupled to the connector handle 2 electric, said electric head connector 2.1 comprising a number of electric pins sufficient to send and receive all electrical signals between the handle and the head necessary for the correct operation of the medical device.
  • connection 8 which can be a flexible PCB, rigid PCB or a combination of connectors surface mount, through hole or pogo pins for the adaptation of electrical signals, among others.
  • the electronic card 6 is composed of 3 sub-modules, the first one of which is a low-power wireless controller and transmitter module 6.1 which has a microcontroller with one of the following architectures; 8051, ARM or AVR among others and a wireless transmitter that can be Bluetooth 4.0 + LE, 4.1, 4.2, 5.0 or any later version of such technology or other low power wireless transmission technology.
  • a low-power wireless controller and transmitter module 6.1 which has a microcontroller with one of the following architectures; 8051, ARM or AVR among others and a wireless transmitter that can be Bluetooth 4.0 + LE, 4.1, 4.2, 5.0 or any later version of such technology or other low power wireless transmission technology.
  • the second sub-module corresponds to a 6.2 high-voltage controlled source module.
  • This has a voltage converter preferably from +3 VDC to +80 VDC.
  • the topology of this converter can be a "Cockroft Walton Voltage Multiplier” or a "Boost” converter among others.
  • Boost Boost
  • the third sub-module of the electronic card 6 is a buffer amplifier module 6.3 with analog pulse discriminator, said buffer amplifier preferably being 6.3 of a bandwidth of at least 250 [MHz].
  • the interchangeable head of the medical device of the present invention is composed first of all by a head connector 9.1 which is located at one end of the head and in which the head electro-mechanical connector is configured ( 2.1, 4.1) to connect the head to the handle. Attached to said head connector 9.1 is the head body 9.2 which is divided into an initial body portion 9.3, a body tip 9.4 and a central body portion 9.5.
  • the sub-sections of the head can have different lengths, be rigid or flexible, depending on the surgical procedure to be performed.
  • An electrical circuit 11 is configured inside the head, which can go either in sub-section 9.3 or in sub-section 9.4.
  • the head comprises a detector 10 composed of an inorganic scintillator coupled by grease or optical glue to a silicon photomultiplier (SiPM) and a head temperature sensor 12.
  • SiPM silicon photomultiplier
  • the scintillator of the detector is selected from the following crystals: LYSO (Ce), LaBr_3 (Ce), LaCl_3 (Ce) or any other that has a decay time of at most a few tens of [ns], high number of photons emitted by [KeV] absorbed and high density together with a high effective atomic number.
  • the electrical circuit 1 1 has an analog pulse amplifier with a bandwidth preferably of at least 250 [MHz] and an output adapted to 50 [ ⁇ ], electronic filters to eliminate the noise present in the high voltage signal, a circuit pull-up or other configuration such as a pull-down circuit or Wheatstone bridge for reading the temperature sensor of head 12 through a connection 17.2.
  • a circuit pull-up or other configuration such as a pull-down circuit or Wheatstone bridge for reading the temperature sensor of head 12 through a connection 17.2.
  • both the analogous anode signal of the SiPM travels to be amplified in the electrical circuit 11 as well as the supply voltage to the SiPM cathode with the respective voltage correction at different temperatures.
  • Connections 17.1 and 17.2 can be cables properly isolated and adapted to 50 [ ⁇ ] for the case of the analog signal from the SiPM, or they can represent direct connections through flexible, rigid cards or some type of connector such as pogo pins, between others.
  • a connection 17 is also configured inside the head, which can be for example an FFC, FPC cable or a rigid-flexible PCB containing all the signals of interest from or to the electrical circuit 11 and which is finally connected to the electric head connector. 2.1.
  • the connection 17 forms part of the electrical circuit as a rigid-flexible PCB which is connected directly or through a terminal to the head connector 2.1.
  • a laparoscopic clamp terminal 16 is further configured in the body tip 9.4 which can be used to control the body tip 9.4 in robotic or manual surgeries where sub-section 9.5 must be flexible .
  • Figure 3 shows the body tip 9.4 of the interchangeable head illustrated in FIG.
  • Figure 2 next to a possible interchangeable collimator that in its outermost layer is preferably of some material of medical use class Ha such as surgical steel, titanium or others so that it is possible to decontaminate and properly sterilize it.
  • some material of medical use class Ha such as surgical steel, titanium or others so that it is possible to decontaminate and properly sterilize it.
  • the interchangeable heads of the present invention possess an internal collimator 13 configured at the end of the body tip 9.4.
  • Said collimator preferably comprises some of the three fields of vision 14, oriented at 0, 45, 90 degrees with respect to the detector 10.
  • the thickness of the internal collimator 13 can vary depending on the radiopharmaceutical that is desired to be detected in the radioguided surgery .
  • the interchangeable heads are configured to receive an interchangeable collimator that is assembled to the collimator terminal 15 shown in Figure 2.
  • the interchangeable collimator has a collimator connector 15.1, wherein the connection between the collimator terminal 15 and the collimator connector 15.1 can be threaded, magnetized, by thread locking, bayonet connection or any other mechanical configuration that allows the coupling between both parts.
  • the interchangeable collimator material in its inner layer and / or that of the internal collimator 13 may be tungsten, gold or other dense material.
  • the probe described above has been developed to be used in a system for radio-guided procedures, which in addition to the probe itself comprises a user interface that can be implemented in a fixed or portable device such as a Tablet, a Smart phone, a Laptop , etc.
  • a user interface that can be implemented in a fixed or portable device such as a Tablet, a Smart phone, a Laptop , etc.
  • An example of said user interface is illustrated in Figure 4.
  • the user interface wirelessly receives from the probe 18 the data transmitted from the first sub-module of the electronic card of the handle through Bluetooth 5.0, Bluetooth 4.0 or any other low-power wireless technology.
  • the user interface comprises a head selection module 19 for selecting the interchangeable head to be used depending on the type of surgery or procedure that is performed. It also comprises a radiopharmaceutical selection module 20 for choosing the radiopharmaceutical to be detected by the probe such as Tc-99m, F-18, among others. It also has a module for selecting the type and frequency of sound 21.
  • the interface also has a radioactive activity module 22 that counts the detections per second [cps] of the probe or the average recording of the last 10 seconds and based on the selected parameters activates an alarm module 23 that emits a visible alert or audible to the user.
  • the interface also has a photographic module 24 that allows the device to photograph the removed tumor or ganglion along with the record of its maximum activity in counts per second. According to a preferred embodiment, in the captured photographs there is also the record of the date, time, accounts per second and the specification of what was photographed by the device.
  • the interface has a control module 25 for monitoring probe parameters such as the battery charge status, an information module 26 that delivers surgery data, among others. It also has a graphic module 27 that illustrates a temporary graph that shows the radioactive activity detected over time.

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  • Health & Medical Sciences (AREA)
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  • Measuring Leads Or Probes (AREA)

Abstract

L'invention concerne une sonde intra-opératoire pour procédés chirurgicaux radioguidés comprenant : un manche formé par un corps (1), un bouton pour allumer et éteindre (5), une source d'alimentation (3) et une carte électronique (6) ; et une tête qui comprend un circuit électrique (11), un détecteur (10) formé d'un scintillateur inorganique accouplé optiquement à un photomultiplicateur de silicium (SiPM) et un collimateur ; la tête étant formée par un connecteur de tête (9,1) relié à un corps de tête (9.2) ; et le manche comprenant un connecteur électromécanique de manche (2, 4) conçu pour s'accoupler de manière amovible à un connecteur électromécanique de tête (2,1, 4,1) placé dans le connecteur de tête (9,1). L'invention concerne également un système pour mettre en oeuvre des procédés raduiguidés au moyen de la sonde proposée.
PCT/CL2017/050062 2017-11-10 2017-11-10 Sonde respiratoire pour procédés chirurgicaux radioguidés Ceased WO2019090441A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PE2020000476A PE20210541A1 (es) 2017-11-10 2017-11-10 Sonda intraoperatoria para procedimientos quirurgicos radioguiados
MX2020004832A MX2020004832A (es) 2017-11-10 2017-11-10 Sonda intraoperatoria para procedimientos quirurgicos radioguiados.
PCT/CL2017/050062 WO2019090441A1 (fr) 2017-11-10 2017-11-10 Sonde respiratoire pour procédés chirurgicaux radioguidés
ARP180103287A AR113494A1 (es) 2017-11-10 2018-11-09 Sonda intraoperatoria para procedimientos quirúrgicos radioguiados

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CL2017/050062 WO2019090441A1 (fr) 2017-11-10 2017-11-10 Sonde respiratoire pour procédés chirurgicaux radioguidés

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WO2019090441A1 true WO2019090441A1 (fr) 2019-05-16

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MX (1) MX2020004832A (fr)
PE (1) PE20210541A1 (fr)
WO (1) WO2019090441A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021209842A1 (fr) * 2020-04-15 2021-10-21 Consiglio Nazionale Delle Ricerche Détecteur gamma directionnel
IT202100027752A1 (it) * 2021-10-29 2023-04-29 Consiglio Nazionale Ricerche Rivelatore scintigrafico intracavitario

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WO1997003369A1 (fr) * 1995-07-13 1997-01-30 Pol.Hi.Tech. S.R.L. Sonde chirurgicale pour la laparoscopie ou la localisation de tumeurs intracavitaires
US5635717A (en) * 1992-07-17 1997-06-03 Dimason Apparatus for detecting and locating radioactive biological markers
US5987350A (en) * 1997-10-10 1999-11-16 Neoprobe Corporation Surgical probe apparatus and system
US6204505B1 (en) * 1998-10-06 2001-03-20 Neoprobe Corporation Surgical probe apparatus and system
EP1542039A1 (fr) * 2002-08-21 2005-06-15 Hamamatsu Photonics K.K. Detecteur de rayonnement
US20090177082A1 (en) * 2006-05-16 2009-07-09 Silicon Instruments Gmbh System Comprising a Gamma Probe and a Control Device
WO2017075080A1 (fr) * 2015-10-27 2017-05-04 Devicor Medical Products, Inc. Appareil et système à sonde chirurgicale et leur procédé d'utilisation

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Publication number Priority date Publication date Assignee Title
US5635717A (en) * 1992-07-17 1997-06-03 Dimason Apparatus for detecting and locating radioactive biological markers
WO1997003369A1 (fr) * 1995-07-13 1997-01-30 Pol.Hi.Tech. S.R.L. Sonde chirurgicale pour la laparoscopie ou la localisation de tumeurs intracavitaires
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