WO2019088883A1 - Transdermal preparation - Google Patents

Abstract

The invention is used to treat acne, post-acne and cellulite. The purpose of the invention is to increase the adhesive capacity, ease of use and effectiveness of a preparation. A transdermal preparation comprises a carrier base made from a plastic biopolymer, water, biologically active substances of natural origin, extracts of animal and/or plant raw material and/or mineral components and an adhesive substance of natural origin. The adhesive substance can contain 10-97% fish glue, 10-97% casein glue, 10-97% bone glue and 10-97% hide glue. According to one method for implementing the proposed invention, a plaster can first be produced; however, the invention can also be used in the form of masks, creams and transdermal systems.

Description

 TRANSDERMAL PREPARATION

 Description of the invention

 The invention relates to a broad-spectrum and can be used for the treatment of acne, post-acne, cellulite.

 Known "Mask on bone glue" CN 103735475 [1], containing 20 g of bone glue, 30 g of pectin, 50 g of skimmed milk, 10 g of propolis and 5 g of vitamin C.

 The disadvantage is the limited application due to technological limitations inherent in compositions based on bone glue.

 The closest solution is the “Applicator for cosmetic or therapeutic, prophylactic and thermal procedures” RU PM 82548 [2], containing a carrier base made of plastic biopolymer, while the base contains gelatin or polyethylene oxide as a plastic biopolymer, and biologically active substances of natural origin, it contains extracts of animal and / or vegetable raw materials and / or mineral components.

 A disadvantage of the known composition is the low adhesive ability, which leads to inconvenience of use and reduced efficiency.

 The aim of the invention is to increase the adhesiveness of the drug for the treatment of acne, postacne, cellulite, leading to improved usability and efficiency.

 The goal is achieved by the fact that a transdermal preparation containing a carrier base made of plastic biopolymer (containing bound water), and as biologically active substances of natural origin it contains extracts of animal and / or vegetable raw materials and / or mineral components, characterized by the fact that additionally contains an adhesive (or a mixture of adhesives) of natural origin (with increased adhesion to the human skin).

The adhesive may contain fish glue. Fish glue is made from various organs of fish rich in connective tissue. Transparent, has no smell, no taste. For the preparation of glue used water bath. The fish glue plates are broken into small pieces and poured into special dishes, poured with cold water so that it covers the glue plates, and left in this form for 5-15 hours. Then heated on a water bath and boiled for gluten, filtered through cheesecloth. The adhesive may contain casein glue. Casein glue is a natural glue of animal origin, the main substance of which is casein derived from milk protein.

 The adhesive may contain bone glue. To obtain glue, animal bones are cleaned, degreased, treated with a weak solution of sulfuric acid to remove mineral salts, and then boiled in special apparatuses in which the raw material is exposed to repeated exposure to steam and water. As a result of this treatment, the collagen present in the bones is converted into gluten, which is an adhesive. In order to prepare a liquid from dry bone glue or quarter glue, tiles of bone glue or quarter glue are broken into pieces, crushed and soaked for 12-24 hours in cold water, then boiled in a water bath at a temperature not exceeding 70-90 ° C and not long overheating. A warm glue solution is applied, not lower than 30 degrees Celsius, then mixed with the second substance, then cosmetic / medicinal essential oils, oil or extract or other extracts are added according to the intended recipe, depending on the purpose of this or that composition.

 The adhesive may contain mezdrovy glue. Mezdrovy glue - produced from the core (inner side of uncut skin), as well as animal skin scraps. In addition to gelatin, it contains oligopeptides formed by hydrolysis of keratin. Due to the high cysteine content, these oligopeptides form disulfate bridges during setting and drying of the glue, thereby achieving a special strength of adhesive bonding. Raw materials are processed in lime milk, and then with a solution of hydrochloric and sulfuric acid. To obtain high-quality glue from the core, it is cooked at a temperature not exceeding 70-90 ° C

 The quantitative composition of the ingredients of the adhesive is selected on the basis of the characteristics of the raw materials and the need to achieve the quality of the adhesive ability of the drug.

 Gelatin or pectin or agar-agar can be used as plastic biopolymer. The technology of preparation of these biopolymers containing water is widely known and provides the necessary properties of a transdermal therapeutic drug.

In the present invention, only natural components are used and one of the objectives of the present invention in the delivery of therapeutic ingredients contained in extracts of animal or vegetable origin to the surface of the skin, followed by diffusion under the surface of the skin, into the skin. One of the methods of implementing the proposed invention involves the preliminary manufacture patch, but it is also possible to use in the form of masks, creams, transdermal therapeutic systems and other parenteral dosage forms for external use.

 For the manufacture of the drug, gelatinous or similar preparations prepared by adding water and brought to readiness in a water bath (using pectin, agar-agar) are used, mixed with the adhesive composition, then functional additives containing active ingredients (algae extract, pepper oil , milk thistle extract, etc.). Unless otherwise specified, extracts are used on a water-alcohol basis, but other types of extracts are not excluded.

 The mask with the current composition, which is initially located on the base, is applied to the face or another part of the body, and the base is removed. Either the base (fabric, non-woven or polymer) remains and is then removed with the remnants of the active substance. The main difference is the use of gelatin (or analogs such as pectin or agar-agar) and adhesive composition. Gelatin is used to evenly distribute the (predominantly aqueous) composition of the active substance, and the glue (mainly of biological origin) is needed to fix this mask on human skin.

 The use of the proposed drug in the form of patches according to the invention is illustrated by the following examples.

 EXAMPLE 1.

Patient O., 29, turned to a beauty salon "A" on the treatment of the initial stage of cellulite. Visually, skin roughness, the so-called “orange peel” effect, is noted, its tone is reduced. The use of anti-cellulite patches in the complex treatment of cellulite is proposed. After the peeling procedure using sea salt and essential oils of orange, lemon, oregano, the patient was prescribed to wear a plaster on a fabric basis, the active adhesive composition of which included gelatin in an amount of 20% by weight, fish glue in an amount of 15%, albumin in an amount of 20% , extract of hot pepper 20% by weight, extract of mint 5% by weight, orange extract 5% by weight, algae extract 15%. The patch was worn by the patient without removing 16-24 hours. The number of procedures used at home is 10. Patient O. noted that the use of the patch alone does not require much effort and is economical due to the uniform distribution of the active substance over the surface of the patch. The proposed method consisting of 1 salon procedure, including the application of the first patch and 9 independent ones, significantly improved the appearance of the skin; in problem areas, the volume decreased by 1.5 cm. The skin gained tone.

 EXAMPLE 2.

 Patient V., 39 years old, manifestations of orange peel on her legs. There are no contraindications for the appointment of a massage, it is proposed to use standard anti-cellulite techniques using peeling, massage and applying a patch with a glue active substance applied to the substrate consisting of 10% by weight gelatin, 20% by weight of casein glue, extract of hot pepper 30% by weight, mint extract 5 % weight, orange extract 5% weight, algae extract 30%. The number of procedures is 10, the patient was asked to wear a plaster for 12 hours, starting with sticking the plaster daily at 8 am and removing the plaster at 8 pm. After a course of independent 10 procedures in a patient V., the condition of the skin in the problem areas, buttocks, thighs, objectively improved, the patient noted a decrease in the volume of the body at the sites of using patches, leveling and improving skin turgor. It was also confirmed the ease and ease of use of the patch at home. The courses of treatment can be repeated regularly, with prophylactic purposes, the sessions are recommended to be held once every 2-3 months.

 EXAMPLE 3.

 Patient E., 46 years old, flabby facial skin, deep facial wrinkles, circles under the eyes. It is proposed to use a mask applied on the face for 20 minutes during the week, along with electrophoresis of the skin of the face, scrubbing and deep cleansing of the skin of the face by washing with cosmetic preparations containing acids.

 The composition of the mask, initial substances: gelatin -30%, bone glue -2%, algae extract -28%, dandelion infusion -20%, plantain extract -20%. After a course of procedures in a patient E., the condition of the skin of the face objectively improved - the patient noted a more healthy skin color, a significant reduction of wrinkles. The courses of treatment can be repeated regularly, with the preventive purpose it is recommended to hold the sessions once every 2 months.

 EXAMPLE 4.

Catherine B, 29, appealed for a rash on her face. It was recommended to use the proposed transdermal preparation in the form of a patch with the composition: gelatin 35% by weight, fish glue 15% by weight, sage extract 25% by weight, extract Althea 10 weight%, infusion of wild rosemary 15 weight%, for 7 days, then - as needed.

 With repeated visual observation of the skin condition of Catherine B., there was a noticeable decrease in lesions on the skin of the face and noticeable blanching of the post-acne.

 Ekaterina B., gave a positive assessment of this drug, and also noted the ease of use. It was recommended to continue to use the tool as needed.

 Industrial Applicability. The claimed invention can be successfully used for the production and use of broad-spectrum drugs.

Claims

Claim  1. Transdermal preparation for the treatment of acne, postacne, cellulite and containing a carrier base made of plastic biopolymer, and as biologically active substances of natural origin it contains extracts of animal and / or vegetable raw materials and / or mineral components, characterized in that it additionally contains adhesive substance or mixture of adhesives of natural origin.  2. The preparation of claim 1, wherein the adhesive contains fish glue.  3. The preparation of claim 1, wherein the adhesive contains casein glue.  4. The preparation according to claim 1, characterized in that the adhesive contains bone glue.  5. The preparation according to claim 1, characterized in that the adhesive substance contains mezdrovy glue.  6. The preparation according to claim 1, characterized in that gelatin or pectin or agar-agar is used as a plastic biopolymer.