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WO2019086955A3 - Quantum plasmonic resonant energy transfer and ultrafast photonic pcr - Google Patents

Quantum plasmonic resonant energy transfer and ultrafast photonic pcr Download PDF

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Publication number
WO2019086955A3
WO2019086955A3 PCT/IB2018/001363 IB2018001363W WO2019086955A3 WO 2019086955 A3 WO2019086955 A3 WO 2019086955A3 IB 2018001363 W IB2018001363 W IB 2018001363W WO 2019086955 A3 WO2019086955 A3 WO 2019086955A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
diagnostic
quantum
pcr
energy transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/001363
Other languages
French (fr)
Other versions
WO2019086955A2 (en
Inventor
Luke P. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National University of Singapore
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Singapore filed Critical National University of Singapore
Priority to US16/760,983 priority Critical patent/US20200306757A1/en
Priority to CN201880084955.6A priority patent/CN111542394A/en
Publication of WO2019086955A2 publication Critical patent/WO2019086955A2/en
Publication of WO2019086955A3 publication Critical patent/WO2019086955A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/628—Detection means characterised by use of a special device being a surface plasmon resonance spectrometer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Fluid Mechanics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A rapid and precision molecular diagnostic chip making use of quantum plasmonic resonance energy transfer is disclosed for performing ultrafast polymerase chain reaction (PCR). The chip includes functionally graded microfluidic structures capable of receiving and conveying a sample using self-powered capillary pumping and capable of performing on-chip separation and target pathogen lysis. The chip can include optical traps to selectively trap and enrich various constituents of the sample, such as cell-free deoxyribonucleic acids (cfDNAs) and exosomes. In some cases, a processing device can receive a diagnostic chip, induce PCR within the diagnostic chip, and optionally detect diagnostic data from the samples within the diagnostic chip.
PCT/IB2018/001363 2017-11-01 2018-10-31 Quantum plasmonic resonant energy transfer and ultrafast photonic pcr Ceased WO2019086955A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16/760,983 US20200306757A1 (en) 2017-11-01 2018-10-31 Quantum plasmonic resonant energy transfer and ultrafast photonic pcr
CN201880084955.6A CN111542394A (en) 2017-11-01 2018-10-31 Quantum plasma resonance energy transfer and ultrafast photon PCR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762580372P 2017-11-01 2017-11-01
US62/580,372 2017-11-01

Publications (2)

Publication Number Publication Date
WO2019086955A2 WO2019086955A2 (en) 2019-05-09
WO2019086955A3 true WO2019086955A3 (en) 2019-08-29

Family

ID=66332918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/001363 Ceased WO2019086955A2 (en) 2017-11-01 2018-10-31 Quantum plasmonic resonant energy transfer and ultrafast photonic pcr

Country Status (3)

Country Link
US (1) US20200306757A1 (en)
CN (1) CN111542394A (en)
WO (1) WO2019086955A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110476031A (en) * 2017-04-04 2019-11-19 日东电工株式会社 Method and device for producing freeze-dried body
GB201721611D0 (en) * 2017-12-21 2018-02-07 Univ College Dublin Nat Univ Ireland Dublin Addressable plasmonic arrays
WO2019173283A1 (en) 2018-03-05 2019-09-12 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
US12292380B2 (en) * 2018-07-25 2025-05-06 Cornell University Integrated microfluidic device for capture and spectroscopic characterization of live cells under various treatment conditions
EP3757549A1 (en) 2019-06-26 2020-12-30 University College Dublin, National University of Ireland, Dublin Addressable plasmonic arrays
KR102267315B1 (en) * 2019-12-03 2021-06-18 고려대학교 산학협력단 A device for measuring particle size of sample
EP4150109A4 (en) * 2020-05-15 2024-06-05 The Trustees of Columbia University in the City of New York Apparatus and methods for rapid nucleic acid detection
CN112083444B (en) * 2020-08-19 2021-06-08 中国民用航空总局第二研究所 Low-latitude airport ionosphere short-time prediction method considering plasma bubbles
US20220091031A1 (en) * 2020-09-18 2022-03-24 Salvus, Llc Interferometric Detection and Quantification System and Methods of Use in Chemical Processing
US12399172B2 (en) 2020-09-18 2025-08-26 Salvus, Llc Interferometric detection and quantification system and methods of use in healthcare
US11994504B2 (en) 2020-09-18 2024-05-28 Salvus, Llc Interferometric detection and quantification system and methods of use in food processing and food supply chain
US11740177B2 (en) 2020-09-18 2023-08-29 Salvus, Llc Interferometric detection and quantification system and methods of use in aquatics
KR102555474B1 (en) * 2021-05-14 2023-07-14 성균관대학교산학협력단 Apparatus for amplifying and detecting nucleci acid at isothermal condition and method for amplifying and detecting nucleci acid at isothermal condition using the same
KR102731770B1 (en) * 2022-06-14 2024-11-20 성균관대학교산학협력단 Plasmonic metal nano particle array, manufacturing method for the same, and pcr diagnostic device including the same
KR102824202B1 (en) * 2022-06-14 2025-06-25 성균관대학교산학협력단 Pcr platform, manufacturing method for the same, and field diagnosis method using the same
KR102826482B1 (en) * 2022-06-15 2025-06-27 한국과학기술원 Thermal control board and its manufacturing method
US20240027266A1 (en) * 2022-07-25 2024-01-25 Hyperspectral Corp. Systems and methods for detecting particles of interest using spectral analysis

Citations (5)

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US20080066549A1 (en) * 2006-09-18 2008-03-20 Oldham Mark F Methods, systems and apparatus for light concentrating mechanisms
US20120028270A1 (en) * 2009-02-17 2012-02-02 Geddes Chris D Metal-enhanced bioluminescence: an approach for monitoring biological bioluminescent processes
US20130070459A1 (en) * 2011-09-16 2013-03-21 Korea University Industrial & Academic Collaboration Foundation Optical devices and methods of controlling propagation directions of light from the optical devices
WO2015031189A1 (en) * 2013-08-26 2015-03-05 Sienna Labs, Inc. Targeted delivery of nanoparticles to skin surface
WO2015188182A1 (en) * 2014-06-06 2015-12-10 Northeastern University Heterogeneous optical slot antenna and method for single molecule detection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080066549A1 (en) * 2006-09-18 2008-03-20 Oldham Mark F Methods, systems and apparatus for light concentrating mechanisms
US20120028270A1 (en) * 2009-02-17 2012-02-02 Geddes Chris D Metal-enhanced bioluminescence: an approach for monitoring biological bioluminescent processes
US20130070459A1 (en) * 2011-09-16 2013-03-21 Korea University Industrial & Academic Collaboration Foundation Optical devices and methods of controlling propagation directions of light from the optical devices
WO2015031189A1 (en) * 2013-08-26 2015-03-05 Sienna Labs, Inc. Targeted delivery of nanoparticles to skin surface
WO2015188182A1 (en) * 2014-06-06 2015-12-10 Northeastern University Heterogeneous optical slot antenna and method for single molecule detection

Also Published As

Publication number Publication date
WO2019086955A2 (en) 2019-05-09
CN111542394A (en) 2020-08-14
US20200306757A1 (en) 2020-10-01

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