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WO2019085114A1 - Procédé d'imagerie de capture d'écran en temps réel dans le domaine de la fréquence spatiale avec démodulation multifréquence - Google Patents

Procédé d'imagerie de capture d'écran en temps réel dans le domaine de la fréquence spatiale avec démodulation multifréquence Download PDF

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Publication number
WO2019085114A1
WO2019085114A1 PCT/CN2017/113692 CN2017113692W WO2019085114A1 WO 2019085114 A1 WO2019085114 A1 WO 2019085114A1 CN 2017113692 W CN2017113692 W CN 2017113692W WO 2019085114 A1 WO2019085114 A1 WO 2019085114A1
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WIPO (PCT)
Prior art keywords
real
modulation
spatial
frequency
imaging method
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Ceased
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PCT/CN2017/113692
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English (en)
Chinese (zh)
Inventor
徐敏
林维豪
曹自立
陈新林
曾碧新
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Wenzhou Medical University
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Wenzhou Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7228—Signal modulation applied to the input signal sent to patient or subject; Demodulation to recover the physiological signal

Definitions

  • the invention relates to a real-time single-shot multi-frequency demodulation spatial frequency domain imaging method.
  • the present invention provides a real-time single-shot multi-frequency demodulation spatial frequency domain imaging method.
  • the invention provides a real-time single-shot multi-frequency demodulation spatial frequency domain imaging method, which comprises the following steps:
  • the spatial modulation pattern comprising components of a plurality of modulation frequencies
  • the modulation depth is obtained. ,among them Is the intensity of the ith modulation frequency component of the incident, Is the incident DC component intensity;
  • a spatial modulation pattern is applied to the object to be tested through the beam splitter.
  • the single-shot multi-frequency demodulation method can resolve the DC values I DC and the shunt values I AC of the respective reflected light intensities of the plurality of spatial modulation frequencies in a single pattern of the plurality of spatially modulated frequencies . i , to obtain optical information of different depths.
  • a real-time single-shot multi-frequency demodulation spatial frequency domain imaging method based on the above-mentioned application in depth-resolved imaging.
  • the invention has the beneficial effects of solving the problem that the traditional demodulation technology is slow and has motion ghosting, and the demodulation technology has a high signal to noise ratio, and the SSMD-SFDI system constructed by the technology can demodulate the MTF in real time. Therefore, optical information and physiological information can be acquired in real time.
  • Figure 1 is a schematic diagram of the comparison between SSMD and standard three-phase shifting technology.
  • Figure 2 is a schematic diagram of an SSMD-SFDI device.
  • Figure 3 shows the concentration of oxyhemoglobin in a typical subject in a forearm reactive hyperemia experiment.
  • Figure 4 is a graphical representation of melanin content and skin layer thickness in a forearm reactive hyperemia experiment.
  • Fig. 5 is a graph showing the absorption coefficient at each wavelength of the epidermal layer (a-c) and the dermis layer (d-f) and the scattering coefficient (g) and scattering ability (h) of the skin.
  • Figure 6 shows the measured area under the SSMD-SFDI system, and the dotted rectangular area is the area of interest.
  • Fig. 7 is a distribution diagram of normal tissue and black sputum optical parameters (absorption coefficient (a-f), scattering coefficient (g) and scattering ability (h) of each wavelength layer).
  • Figure 8 shows normal tissue and black sputum physiological parameters (oxygenated hemoglobin (a), hypoxic hemoglobin (b), total oxygenated hemoglobin (c), oxygen saturation (d), melanin (e) and epidermal thickness (f)) Distribution map.
  • the invention provides a real-time single-shot multi-frequency demodulation spatial frequency domain imaging method
  • the single-shot multi-frequency demodulation method can separately analyze the DC values I DC and the shunt values I AC, i of the respective reflected light intensities of a plurality of spatial modulation frequencies in a pattern composed of a plurality of spatial modulation frequencies. Deep optical information;
  • the single-shot multi-frequency demodulation method can demodulate the DC value I DC of the reflected light intensity and the shunt value I AC, i for each modulation frequency for a single spatial modulation frequency pattern .
  • the incident light intensity I 0 is used to obtain the modulation depth. among them Is the incident light intensity of the reflected light intensity I AC,i at each modulation frequency, Is the incident light intensity of the I DC ;
  • the invention can be applied to modeling on 3D reconstruction.
  • the invention can be applied to large areas of skin imaging.
  • the invention can be applied to large area imaging of the mucosal layer of the endoscope surface.
  • the invention can project a spatial modulation pattern of a phase through the DMD, and other equipment can also be used, and then the CCD can be used to acquire the reflected light intensity after the diffuse reflection of the object to be tested, and CCD, spectrometer, fiber optic probe and the like can also be used here. .
  • the invention can quickly resolve the MTF by a spatial modulation pattern of a single phase, and solves the problem of the traditional three-phase shift.
  • the SSMD technology can improve the signal-to-noise ratio of the image.
  • the single-shot multi-frequency demodulation method used in the third step can demodulate the DC value I DC of the reflected light intensity in a single spatial modulation frequency pattern and corresponding to each modulation frequency, compared with the conventional standard three-phase shift method.
  • the shunt value I AC,i is maintained and a high signal to noise ratio is maintained. It overcomes the problem that the traditional standard three-phase shifting method requires three spatial modulation frequency patterns of different phases to work normally, and the motion ghosts and the inability to resolve in real time. Due to the different spatial modulation frequencies, the detection depths are different (the larger the spatial frequency, the shallower the detection depth). Therefore, multiple spatial modulation frequencies can be combined to obtain optical information of different depths, which can be used for 3D reconstruction.
  • the SSMD technology is used to quickly demodulate the DC and AC information of the reflected pattern.
  • FIG 3 shows the typical changes in oxyhemoglobin concentration, deoxyhemoglobin concentration, total hemoglobin concentration, and oxygen saturation in a forearm reactive hyperemia experiment.
  • the cuff blocks blood flow to the veins and arteries, blood is deposited in the subcutaneous blood vessels due to obstruction of the distal vein, causing the blood vessels to swell and expand, resulting in a total increase in total hemoglobin (the sum of HbO 2 and Hb, (Fig. 3(c)).
  • Vascular obstruction leads to rapid depletion of oxygen in the tissue, resulting in a rapid decrease in tissue oxyhemoglobin (HbO 2 concentration, Figure 3 (a)) and an increase in tissue deoxyhemoglobin concentration (Hb, Figure 3 (b)).
  • Skin black mites were detected using the SSMD-SFDI system in combination with a layered structure mapping model.
  • Figure 8 shows oxyhemoglobin (a), hypoxic hemoglobin (b), total hemoglobin (c), blood oxygen saturation (d), melanin (e) and epidermal layer thickness (f), respectively.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
  • Psychiatry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un procédé d'imagerie de capture d'écran en temps réel dans le domaine de la fréquence spatiale avec démodulation multifréquence. Le procédé comprend les étapes consistant à : projeter un motif de modulation spatiale sur un objet devant être inspecté, le motif de modulation pouvant comprendre des composantes de multiples fréquences de modulation; collecter une intensité de lumière réfléchie lorsqu'elle est réfléchie de manière diffuse par l'objet devant être inspecté; acquérir une valeur de courant continu et une valeur de courant de dérivation de l'intensité de lumière réfléchie au moyen d'une formule SSMD; une fois la valeur de courant continu et la valeur de courant de dérivation de l'intensité de lumière réfléchie acquises, utiliser une intensité de lumière incidente pour arriver à une profondeur de modulation; et, sur la base de la profondeur de modulation acquise, acquérir un paramètre optique correspondant à une profondeur de modulation MTF correspondante via une comparaison avec un modèle de propagation d'une lumière dans un support. L'invention résout les problèmes de lenteur et de mouvement fantôme d'une technique de démodulation classique, et propose une technique de démodulation apte à fournir un rapport signal sur bruit élevé. Un système SSMD-SFDI réalisé selon la présente technique est apte à démoduler une MTF en temps réel, et à acquérir ainsi des informations optiques et des informations physiologiques en temps réel.
PCT/CN2017/113692 2017-10-30 2017-11-30 Procédé d'imagerie de capture d'écran en temps réel dans le domaine de la fréquence spatiale avec démodulation multifréquence Ceased WO2019085114A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711041861.4A CN107802269A (zh) 2017-10-30 2017-10-30 实时单次快照多频解调空间频域成像方法
CN201711041861.4 2017-10-30

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WO2019085114A1 true WO2019085114A1 (fr) 2019-05-09

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WO (1) WO2019085114A1 (fr)

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Publication number Priority date Publication date Assignee Title
TWI687200B (zh) * 2018-07-16 2020-03-11 大立光電股份有限公司 光學脈波影像量測儀及脈波形變量測方法
CN111265188A (zh) * 2020-01-21 2020-06-12 温州医科大学 一种基于局部微循环的糖尿病足风险评估装置及方法
CN114173030B (zh) * 2021-11-04 2022-11-08 华中农业大学 基于智能手机的空间频域单次快照成像装置及其方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
US20100079684A1 (en) * 2008-09-29 2010-04-01 Seiko Epson Corporation Image processing device, projection system, and image processing method
CN103679652A (zh) * 2013-11-29 2014-03-26 北京空间机电研究所 一种大幅提高成像质量的图像复原系统
CN103954957A (zh) * 2014-05-22 2014-07-30 北京空间机电研究所 一种基于分离大气mtf的遥感影像大气邻近效应校正方法
CN105245761A (zh) * 2015-09-30 2016-01-13 温州医科大学 单次快照多频解调方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100079684A1 (en) * 2008-09-29 2010-04-01 Seiko Epson Corporation Image processing device, projection system, and image processing method
CN103679652A (zh) * 2013-11-29 2014-03-26 北京空间机电研究所 一种大幅提高成像质量的图像复原系统
CN103954957A (zh) * 2014-05-22 2014-07-30 北京空间机电研究所 一种基于分离大气mtf的遥感影像大气邻近效应校正方法
CN105245761A (zh) * 2015-09-30 2016-01-13 温州医科大学 单次快照多频解调方法

Non-Patent Citations (1)

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Title
CAO, ZILI: "Research on Theory and Method of Real-Time Spatial Frequency Domain Imaging", BACHELOR THESIS, 28 February 2017 (2017-02-28), pages 19, 24 - 29 *

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