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WO2019081477A1 - SUBSTITUTED PYRAZOLE AND THEIR SALTS AND THEIR USE AS HERBICIDAL ACTIVE SUBSTANCES - Google Patents

SUBSTITUTED PYRAZOLE AND THEIR SALTS AND THEIR USE AS HERBICIDAL ACTIVE SUBSTANCES

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Publication number
WO2019081477A1
WO2019081477A1 PCT/EP2018/078983 EP2018078983W WO2019081477A1 WO 2019081477 A1 WO2019081477 A1 WO 2019081477A1 EP 2018078983 W EP2018078983 W EP 2018078983W WO 2019081477 A1 WO2019081477 A1 WO 2019081477A1
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WIPO (PCT)
Prior art keywords
alkyl
cycloalkyl
compounds
cio
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/078983
Other languages
German (de)
French (fr)
Inventor
Thomas Müller
Birgit Kuhn
Uwe Döller
Christopher Robert GARDNER
Andreas Van Almsick
David Michael BARBER
Hansjörg Dietrich
Elmar Gatzweiler
Anu Bheemaiah MACHETTIRA
Christopher Hugh Rosinger
Dirk Schmutzler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer CropScience AG
Original Assignee
Bayer AG
Bayer CropScience AG
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Filing date
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Publication of WO2019081477A1 publication Critical patent/WO2019081477A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Definitions

  • the invention relates to the technical field of crop protection agents, in particular that of herbicides for the selective control of weeds and grass weeds in crops. Specifically, this invention relates to substituted pyrazoles and their salts, to processes for their
  • substituted pyrazoles or their salts as herbicidal active ingredients which carry one of the defined substituted phenyl, thiophene, thiazole or pyrimidine radicals on the pyrazole is, however, not yet described.
  • substituted pyrazoles or their salts as herbicidal active compounds which carry one of the defined substituted phenyl, thiophene, thiazole or pyrimidine radicals on pyrazole are particularly suitable as herbicides.
  • 10 is hydrogen, halogen, cyano, (Ci-Cg) -alkyl, (Ci-Cg) -haloalkyl, (Ci-Cg) -cyanoalkyl, (Ci-Cg) -hydroxyalkyl, (Ci-Cg) -alkoxy- ( Ci-Cg) -alkyl, (C 3 -Cio) -cycloalkyl, (C 3 -Cio) -cycloalkyl (Ci-Cg) -alkyl, (C 3 -Cg) -Halocycloalkyl, (Ci-Cg) -alkoxy, (Ci-Cg) -haloalkoxy, (Ci-Cg) -alkylthio, (Ci-Cg) -haloalkylthio, (C 3 -Cg) -cycloalkylthio, (Ci-Cg) -alkylsulfmyl
  • R is hydrogen, (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkyl, (C 2 -C 10) -alkenyl, (C 3 -C 10) -alkynyl,
  • the compounds of general formula (I) can be prepared by addition of a suitable organic compound.
  • inorganic or organic acid such as mineral acids such as HCl, HBr, H2SO4, ftPO.sub.i or HNO.sub.3, or organic acids, e.g. Carboxylic acids, such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid or salicylic acid, or sulfonic acids, such as p-toluenesulfonic acid, to a basic group, e.g. Amino, alkylamino, dialkylamino, piperidino, morpholino or pyridino, salts. These salts then contain the conjugate base of the acid as an anion. Suitable substituents which are in deprotonated form, e.g. Sulfonic acids, certain
  • Sulfonklareamide or carboxylic acids may form internal salts with their turn protonatable groups, such as amino groups. Salt formation can also be due to the action of a base
  • Suitable bases are, for example, organic amines, such as trialkylamines, morpholine, piperidine and pyridine and ammonium, alkali or
  • Potassium hydroxide, sodium and potassium carbonate and sodium and potassium bicarbonate are compounds in which the azide hydrogen is replaced by a cation suitable for agriculture, for example metal salts, in particular alkali metal salts or
  • Alkaline earth metal salts in particular sodium and potassium salts, or else ammonium salts, salts with organic amines or quaternary ammonium salts, for example with cations of the formula [NR a R b R c R d ] + wherein R a to R d are each independently an organic radical, in particular alkyl, aryl, arylalkyl or alkylaryl. Also suitable are alkylsulfonium and
  • Alkylsulfoxoniumsalze such as (Ci-C4) -trialkylsulfonium and (Ci-C4) -Trialkylsulfoxoniumsalze.
  • the substituted pyrazoles of the general formula (I) according to the invention may be present in various tautomeric structures, all of which are intended to be encompassed by the general formula (I).
  • Preferred subject of the invention are compounds of general formula (I), wherein Q is the groups Q-l. l to Q-7.1
  • Z for the group is hydrogen, halogen, cyano, (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, (C 1 -C 6 ) -cyanoalkyl, (C 1 -C 6 ) -hydroxyalkyl, (C 1 -C 6 ) -alkoxy (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl- (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -halocycloalkyl, ( Ci-C 6) alkoxy, (Ci-C 6) -haloalkoxy, (Ci-C 6) alkylthio, (Ci-C 6) haloalkylthio, (C 3 -C 6) -cycloalkylthio, (Ci-C
  • R is hydrogen, (Ci-C 8) -alkyl, (Ci-C8) -haloalkyl, (C 2 -C 8) alkenyl, (C3-C8) alkynyl, (Ci-C8) - alkoxy (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -haloalkoxy- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylthio (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -haloalkylthio - (Ci-C 8) alkyl, (C 3 -C 8) cycloalkyl, hydroxy (Ci-C 8) alkylcarbonyl, amino (Ci-C8) alkyl, (Ci-C8) alkoxycarbonyl ( Ci-C 8) alkyl, (Ci-C 8) cyanoalkyl,
  • a particularly preferred subject of the invention are compounds of the general formula (I) in which Q represents the groups Q-1. l to Q-7.1
  • Q-4.2 Q-5.1 Q-6.1 Q-7.1 stands for the group represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -Halocycloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -haloalkylthio, (C 1 -C 4 ) -alkylsulfmyl, (Ci -C 4) -Haloalkylsulfmyl, (Ci-C 4) alkylsulfonyl, (Ci-C4) haloalkylsulfonyl, represents oxygen or sulfur, is (C
  • R 4 represents hydrogen, (Ci-C 6) -alkyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) -alkenyl, (C 3 -C 6) alkynyl, (Ci-C 6) - Alkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkylthio (C 1 -C 6 ) -alkyl, C 6) -Haloalkylthio- (Ci-C 6) alkyl, (C 3 -C 6) cycloalkyl, hydroxy (Ci-C 6) alkylcarbonyl, amino (Ci-C 6) alkyl, (Ci- C 6) alkoxycarbonyl (Ci-C 6) alkyl, (Ci-C 6) cyan
  • a very particularly preferred subject matter of the invention are compounds of the general formula (I) in which Q denotes the groups Q1. l to Q-7.1
  • Z for the group represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 3) alkyl, (Ci-C 3) -haloalkyl, (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -Halocycloalkyl, (C 1 -C 3 ) -alkoxy, (C 1 -C 3 ) -haloalkoxy, (C 1 -C 3 ) -alkylthio, (C 1 -C 3 ) -haloalkylthio, (C 1 -C 3 ) -alkylsulfmyl, (Ci -C 3) -Haloalkylsulfmyl, (Ci-C 3) alkylsulfonyl, (Ci-C 3) haloalkylsulfonyl, represents oxygen or sulfur,
  • R 1 is (C 1 -C 4 ) -alkyl and (C 1 -C 4 ) -haloalkyl
  • R is (C 1 -C 4 ) -alkyl and (C 1 -C 4 ) -haloalkyl, or wherein R 1 and R 2 together with the C-atom to which they are each bonded, a completely saturated or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, in total 3 Form -7- membered ring stands,
  • R 3 is hydroxy, amino, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 2 -C 4) alkenyl, (C 3 -C 4) alkynyl, (Ci-C 4 ) -Cyanoalkyl, (C 1 -C 4 ) -hydroxyalkyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -halocycloalkyl, (C 3 -C 6 ) -cyanocycloalkyl, (C 3 -C 6 ) cycloalkenyl, (Ci-C 4) -alkyl- (C 3 -C 6) cycloalkyl, (Ci-C4) - alkoxy- (C 3 -C 6) cycloalkyl, (Ci-C 4) haloalkoxy (C 3 -C 6) cycloalkyl, (Ci-
  • R 4 is hydrogen, (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, hydroxycarbonyl- (C 1 -C 6 ) -alkyl, amino- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxycarbonyl - (Ci-C 6 ) -alkyl, or R 3 and R 4 with the N-atom to which they are attached, a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is formed, except the following compound:
  • Y represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 2) alkyl, (Ci-C 2) -haloalkyl, (C 3 -C 4) - cycloalkyl, (Ci-C 2) alkoxy , (C 1 -C 2 ) -haloalkoxy, (C 1 -C 2 ) -alkylthio, (C 1 -C 2 ) -haloalkylthio, (C 1 -C 2 ) -alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 4) -alkyl 2 ) -alkylsulfonyl, (C 1 -C 2 ) -haloalkylsulfonyl, represents oxygen or sulfur, represents (C 1 -C 2 ) -alkyl, is (C 1 -C 2 )
  • Y represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (C 1 -C 2 ) -alkyl, (C 1 -C 2 ) -haloalkyl, (C 3 -C 4) -cycloalkyl, (C 1 -C 2 ) -alkoxy, ( C 1 -C 2 ) -haloalkoxy, (C 1 -C 2 ) -alkylthio, (C 1 -C 2 ) -haloalkylthio, (C 1 -C 2 ) -alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 2 ) Alkylsulfonyl, (C 1 -C 2) - haloalkylsulfonyl,
  • W is oxygen or sulfur
  • R 1 is CH 3 ,
  • R 2 is CH 3 , with the exception of the following compound:
  • Q stands for one of the groupings Q-1.1 to Q-7.1 mentioned specifically in the table above.
  • Z stands for the groups Z-1.1 to Z-1,400.
  • Y is hydrogen, fluorine, chlorine, bromine, iodine, cyano, CH 3 , (Ci) -haloalkyl, (C 3 -C 3 ) -cycloalkyl, (Ci-C 2 ) -alkoxy, (Ci) -haloalkoxy, (Ci C 2 ) alkylthio, (C 1 -C 2 ) -alkylsulfinyl, (C 1 -C 2 ) -alkylsulfonyl,
  • W is oxygen or sulfur; R 1 is CH 3 ,
  • R is CH 3 , with the exception of the following compound:
  • alkylsulfonyl alone or as part of a chemical group - is straight-chain or branched alkylsulfonyl, preferably with 1 to 8, or with 1 to 6
  • Carbon atoms for example (but not limited to) (C 1 -C 6) alkylsulfonyl, such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methyl-propylsulfonyl, 1, 1-dimethylethylsulfonyl, pentylsulfonyl, 1 Methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpent
  • Heteroarylsulfonyl here in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino or alkoxy groups.
  • alkylthio alone or as part of a chemical group - is straight-chain or branched S-alkyl, preferably with 1 to 8, or with 1 to 6
  • Carbon atoms such as (Ci-Cio) -, (CI-C ⁇ ) - or (Ci-C4) -alkylthio, e.g. (but not limited to) (ce-Ce) -alkylthio, such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 1, 1-dimethylpropylthio, 1, 2-dimethylpropylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1, 1 Dimethylbut
  • Cycloalkylthio means according to the invention a bonded via a sulfur atom
  • Alkoxy means an alkyl radical bonded through an oxygen atom, for example (but not limited to) (C 1 -C 6) alkoxy, such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1 , 1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1, 1-dimethylpropoxy, 1, 2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy , 3-methylpentoxy, 4-methylpentoxy, 1, 1-dimethylbutoxy, 1, 2-dimethylbutoxy, 1, 3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy , 2-ethylbutoxy, 1, 1, 2-trimethylpropoxy, 1, 2,2-trimethylpropoxy, 1-ethyl-1-
  • Alkenyloxy means an alkenyl radical bonded through an oxygen atom
  • alkynyloxy means an above an oxygen atom bonded alkynyl group such as (C 2 -C 1 0) -, (C 2 -C 6) - or (C 2 -C 4) alkenoxy, and (C3-C10) -, (C 3 -C 6) - or (C 3 -C 4 ) -alkoxy.
  • Cycloalkyloxy means a cycloalkyl group bonded via an oxygen atom.
  • the number of carbon atoms refers to the alkyl radical in the
  • the number of C atoms here refers to the alkyl radical in the alkoxycarbonyl group, analogously “alkenyloxycarbonyl” and “alkynyloxycarbonyl”, unless otherwise defined elsewhere, according to the invention for alkenyl or alkynyl radicals which are bonded to the skeleton via -O-C ( O), such as (C 2 -C 10) -, (C 2 -C 6 ) - or (C 2 -C 4 ) - alkenyloxycarbonyl or (C3-C10) -, (C 3 -C 6) - or (C3-C4) -
  • the number of C atoms here refers to the alkyl radical in the alkylcarbonyloxy group.
  • aryl means an optionally substituted mono-, bi- or polycyclic aromatic system having preferably 6 to 14, in particular 6 to 10 ring C atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably phenyl.
  • optionally substituted aryl also includes polycyclic systems, such as tetrahydronaphthyl, indenyl, indanyl, fluorenyl, biphenylyl, the binding site being on the aromatic system.
  • Aryl is also generally known from the term “optionally Preferred aryl substituents here are, for example, hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl , Alkoxy, haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroaryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris [alkyl] silyl, bis [alkyl] arylsilyl, bis [alkyl] alkylsilyl,
  • heterocyclic radical contains at least one heterocyclic ring
  • heterocyclic ring in which at least one C atom is replaced by a heteroatom, preferably by a heteroatom from the group N, O, S, P
  • N, O, S, P saturated, unsaturated, partially saturated or heteroaromatic and may be unsubstituted or substituted, wherein the binding site is located on a ring atom.
  • heterocyclyl or heterocyclic ring is optionally substituted, it may be fused with other carbocyclic or heterocyclic rings.
  • polycyclic systems are also included, for example 8-azabicyclo [3.2.1] octanyl, 8-azabicyclo [2.2.2] octanyl or 1-azabicyclo [2.2.1] heptyl.
  • optionally substituted heterocyclyl also become
  • the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, preferably 1 to 4, in particular 1, 2 or 3 heteroatoms in the heterocyclic ring, preferably from the group N, O, and S, but not two
  • Oxygen atoms are to be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4-dihydro-2H-pyrrol-2 or 3-yl, 2,3- Dihydro-1H-pyrrole 1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrol-1 - or 2- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-tetrahydropyridine-2- or 3- or 4- or 5-yl or 6-yl; 1,2,3,6-tetrahydropyridine-1 or 2 or 3 or 4 or 5 or 6-yl; 1,2,3,4-tetrahydropyridine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,4-dihydropyridine-I - or 2- or 3- or 4-yl; 2,3-dihydropyridine-2 or 3 or 4 or 5 or 6-yl; 2,5-dihydropyridine-2- or 3- or 4- or
  • Preferred 3-membered ring and 4-membered ring heterocycles
  • heterocyclyl are a partially or fully hydrogenated heterocyclic radical having two heteroatoms from the group N, O and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazole-3 or 4 or 5-yl; 4,5-dihydro-1H-pyrazole-1 - or 3 or 4 or 5-yl; 2,3-dihydro-1H-pyrazole-1 - or 2 - or
  • 6- or 7-yl 2,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1,3-oxazepine 2- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 6,7-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; l, 3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,4-oxazepan-2- or 3- or 5- or 6- or 7-yl; 2,3,4,5-tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-l,
  • heterocyclyl are a partially or fully hydrogenated heterocyclic radical having 3 heteroatoms from the group N, O and S, such as, for example, l, 4,2-dioxazolidin-2 or 3 or 5-yl; l, 4,2-dioxazol-3 or 5-yl; 1,2,2-dioxazinane-2- or -3- or 5- or 6-yl; 5,6-dihydro-l, 4,2-dioxazine-3 or 5 or 6-yl; l, 4,2-dioxazine-3- or 5- or 6-yl; l, 4,2-dioxazepan-2 or 3 or 5 or 6 or 7-yl; 6,7-dihydro-5H-l, 4,2-dioxazepine-3 or 5 or 6 or 7-yl; 2,3-dihydro-7H-l, 4,2-dioxazepin-2 or 3 or 5 or 6 or 7-yl; 2,3-dihydro-5H-1,
  • heterocycles listed above are preferably, for example, hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, Halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, hydroxycarbonyl, cycloalkoxycarbonyl,
  • Alkylaminocarbonyl bis-alkylaminocarbonyl, cycloalkylaminocarbonyl,
  • the oxo group as a substituent on a ring C atom then means, for example, a carbonyl group in the heterocyclic ring.
  • lactones and lactams are preferably also included.
  • the oxo group may also be attached to the hetero ring atoms, which may exist in different oxidation states, e.g. For example, at N and S, the divalent groups N (O), S (O) (also SO for short) and S (O) 2 (also SO2 for short) occur and form in the heterocyclic ring.
  • N (O) S (O)
  • S (O) 2 also SO2 for short
  • heteroaryl stands for heteroaromatic compounds, ie.
  • heteroaryls are, for example, 1H-pyrrol-1-yl; lH-pyrrol-2-yl; lH-pyrrole
  • Carbon atoms part of another aromatic ring they are fused heteroaromatic systems, such as benzo-fused or multiply fused heteroaromatic.
  • quinolines e.g., quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl
  • Isoquinolines e.g., isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl, isoquinolin-8-yl
  • quinoxaline quinazoline
  • cinnoline 1,5-naphthyridine; 1,6-naphthyridine; 1,7-naphthyridine; 1,8-naphthyridine; 2,6-naphthyridine; 2,7-naphthyridine; phthalazine; Pyridopyrazine
  • heteroaryl are also 5- or 6-membered benzo-fused rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H- Indol-5-yl, 1H-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran 5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1
  • halogen means, for example, fluorine, chlorine, bromine or iodine.
  • halogen means, for example, a fluorine, chlorine, bromine or iodine atom.
  • alkyl means a straight-chain or branched, open-chain, saturated Hydrocarbon radical which is optionally monosubstituted or polysubstituted and which is referred to in the latter case as “substituted alkyl.”
  • Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino or nitro groups, particular preference is given to methoxy , Methyl, fluoroalkyl, cyano, nitro, fluoro, chloro, bromo or iodo.
  • bis also includes the combination of different alkyl radicals, e.g. For example, methyl (ethyl) or ethyl (methyl).
  • Haloalkyl means by the same or different halogen atoms, partially or fully substituted alkyl, alkenyl and alkynyl, for example monohaloalkyl
  • ( Monohaloalkyl) such. CH 2 CH 2 Cl, CH 2 CH 2 Br, CHClCH 3 , CH 2 Cl, CH 2 F; Perhaloalkyl such. B. CCl 3, CC1F 2, CFC1 2 CF 2 CC1F 2, CF 2 CC1FCF 3; Polyhaloalkyl such. CH 2 CHFC1, CF 2 CC1FH, CF 2 CBrFH, CH 2 CF 3; The term perhaloalkyl also encompasses the term perfluoroalkyl.
  • Partially fluorinated alkyl means a straight-chain or branched, saturated hydrocarbon which is monosubstituted or polysubstituted by fluorine, it being possible for the corresponding fluorine atoms to be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain, for example CHFCH3, CH 2 CH 2 F, CH 2 CH 2 CF 3, CHF 2, CH 2 F, CF 3 CHFCF 2
  • Partially fluorinated haloalkyl means a straight-chain or branched, saturated one
  • Hydrocarbon which is substituted by various halogen atoms having at least one fluorine atom, wherein all other optional halogen atoms are selected from the group fluorine, chlorine or bromine, iodine.
  • the corresponding halogen atoms may be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain.
  • Partially fluorinated haloalkyl also includes the complete substitution of halogen with the participation of at least one fluorine atom of the straight-chain or branched chain.
  • Haloalkoxy is, for example, OCF 3 , OCHF 2 , OCH 2 F, OCF 2 CF 3 , OCH 2 CF 3 and OCH 2 CH 2 Cl, and the same applies to haloalkenyl and other radicals substituted by halogen.
  • (C 1 -C 4) -alkyl denotes a short notation for straight-chain or branched alkyl having one to four carbon atoms corresponding to the formula
  • Range for C atoms includes the radicals methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl or tert-butyl.
  • General alkyl radicals having a larger specified range of carbon atoms eg. B. "(Ci-C6) -alkyl”, accordingly also include straight-chain or branched alkyl radicals having a larger number of carbon atoms, ie according to Example, the alkyl radicals having 5 and 6 carbon atoms.
  • the lower carbon skeletons for example having 1 to 6 carbon atoms or in unsaturated groups having 2 to 6 carbon atoms, are preferred.
  • Alkyl radicals including in the assembled radicals such as alkoxy, haloalkyl, etc., mean, for example, methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls, such as n-hexyl, i Hexyl and 1,3-dimethylbutyl, heptyls such as n-heptyl, 1-methylhexyl and 1, 4-dimethylpentyl;
  • Alkenyl and alkynyl radicals have the meaning of the possible unsaturated radicals corresponding to the alkyl radicals, wherein at least one double bond or triple bond is contained. Preference is given to radicals having a double bond or
  • alkenyl in particular also includes straight-chain or branched open-chain
  • Hydrocarbon radicals having more than one double bond such as 1,3-butadienyl and 1,4-pentadienyl, but also allenyl or cumulenyl radicals having one or more cumulated double bonds, such as allenyl (1,2-propadienyl), 1, 2-butadienyl and 1,2,3-pentatrienyl.
  • Alkenyl is, for example, vinyl, which may optionally be substituted by further alkyl radicals, for example (but not limited to) (C 2 -C 6) alkenyl, such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl , 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3 Pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl -2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1, 1-dimethyl-2-propenyl, 1, 2-dimethyl
  • alkynyl in particular also includes straight-chain or branched open-chain
  • C 2 -C 6) -alkynyl denotes, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2 Butinyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl 3 -butynyl, 3-methyl-1-butinyl, 1, 1-dimethyl-2-propynyl, 1-ethyl
  • cycloalkyl means a carbocyclic, saturated ring system preferably having 3-8 ring C atoms, eg cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, cyano, nitro, alkylthio , Haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alkocycarbonyl,
  • Cycloalkylaminocarbonyl In the case of optionally substituted cycloalkyl cyclic systems are included with substituents, wherein substituents having a double bond on
  • alkylidene group such as methylidene
  • polycyclic aliphatic systems are also included, such as, for example, bicyclo [1,1.0] butan-1-yl, bicyclo [1,1-0] butan-2-yl, bicyclo [2.1.0] pentan-1-yl , Bicyclo [1,11] pentan-1-yl, bicyclo [2.1.0] pentan-2-yl, bicyclo [2.1.0] pentan-5-yl, bicyclo [2.1.1] hexyl, bicyclo [2.2.1 ] hept-2-yl, bicyclo [2.2.2] octan-2-yl, bicyclo [3.2.1] octan-2-yl, bicyclo [3.2.2] nonan-2-yl, adamantane-1-yl and
  • spirocyclic aliphatic systems are also included, such as spiro [2.2] pent-1-yl, spiro [2.3] hex-1-yl, spiro [2.3] hex-4-yl, 3-spiro [2.3] hex-5-yl, spiro [3.3] hept-1-yl, spiro [3.3] hept-2-yl.
  • Cycloalkenyl means a carbocyclic, non-aromatic, partially unsaturated ring system preferably having 4-8 C atoms, for example 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl,
  • 3-cyclopentenyl or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1, 3-cyclohexadienyl or 1, 4-cyclohexadienyl, wherein also substituents having a double bond on the cycloalkenyl radical, for.
  • substituents having a double bond on the cycloalkenyl radical for.
  • an alkylidene group such as methylidene
  • substituted cycloalkyl the explanations for substituted cycloalkyl apply correspondingly.
  • alkylidene for example also in the form (C 1 -C 10) -alkylidene, means the radical of a straight-chain or branched open-chain hydrocarbon radical which has a double bond is bound.
  • Cycloalkylidene means a
  • Alkoxyalkyl means an alkoxy group attached via an alkyl group
  • alkoxyalkoxy means an alkoxyalkyl group bonded via an oxygen atom, e.g. (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy.
  • Alkylthioalkyl means an alkylthio radical bonded via an alkyl group
  • Alkylthioalkylthio means an alkylthioalkyl radical bonded via an oxygen atom.
  • Arylalkoxyalkyl stands for an aryloxy radical bound via an alkyl group
  • Heteroaryloxyalkyl means a heteroaryloxy group bonded via an alkyl group.
  • Haloalkoxyalkyl means a haloalkoxy radical attached and "haloalkylthioalkyl” means a haloalkylthio radical attached via an alkyl group.
  • Arylalkyl means an aryl group attached via an alkyl group
  • heteroarylalkyl means a heteroaryl group bonded via an alkyl group
  • heterocyclylalkyl means a heterocyclyl group bonded through an alkyl group.
  • Cycloalkylalkyl means a cycloalkyl radical attached via an alkyl group, for example (but not limited to) cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-cyclopropyleth-1-yl, 2-cyclopropyleth-1-yl, 1-cyclopropylpropyl l -yl, 3-cyclopropylprop-1-yl.
  • haloalkylthio alone or as part of a chemical group - represents straight-chain or branched S-haloalkyl, preferably having 1 to 8, or having 1 to 6 carbon atoms, such as (C 1 -C 5) -, (C 1 -C 5) - or (C 1 -C 4) -haloalkylthio, for example (but not limited to) trifluoromethylthio, pentafluoroethylthio, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio.
  • Halocycloalkyl and “Halocycloalkenyl” mean by the same or different halogen atoms, such as. B. F, Cl and Br, or by haloalkyl, such as. B. trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, for example 1-fluorocycloprop-l -yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobutyl-1, Trifluoromethylcycloprop-1-yl, 2 Trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl,
  • trialkylsilyl alone or as part of a chemical group - is straight-chain or branched Si-alkyl, preferably with 1 to 8, or with 1 to 6
  • Carbon atoms such as tri - [(Ci-Cg) -, (Ci-Ce) - or (Ci-C4) -alkyl] silyl, e.g. (but not limited to) trimethylsilyl, triethylsilyl, tri (n-propyl) silyl, tri (iso-propyl) silyl, tri (n-butyl) silyl, tri (1-methylprop-1-yl) silyl, Tri- (2-methylprop-1-yl) silyl, tri (1,1-dimethyleth-1-yl) silyl, tri (2,2-dimethyl-1-yl) silyl.
  • the compounds of the general formula (I) can exist as stereoisomers.
  • the possible stereoisomers defined by their specific spatial form, such as enantiomers, diastereomers, Z and E isomers, are all encompassed by the general formula (I). If, for example, one or more alkenyl groups are present, diastereomers (Z and E isomers) can occur. For example, if one or more asymmetric carbon atoms are present, enantiomers and diastereomers may occur.
  • Stereoisomers can be distinguished from those in the
  • stereoisomers can be selectively prepared by using stereoselective reactions using optically active sources and / or adjuvants.
  • the invention thus also relates to all stereoisomers which comprises the general formula (I) but are not specified with their specific stereoform, and mixtures thereof.
  • the purification can also by
  • the substituted pyrazoles of the general formula (I) according to the invention can be prepared starting from known processes.
  • the synthetic routes used and investigated are based on commercially available or easily prepared amines, on appropriately substituted aldehydes and on commercially available chemicals such as malonic acid derivatives and nitromethane.
  • the groupings Q, Y, W, R 1 , R 2 , R 3 , R 4 and R 5 of the general formula (I) have the meanings defined above in the following schemes, unless exemplary but non-limiting definitions take place.
  • the synthesis of the compounds of the general formula (Ia) according to the invention is carried out via an amide coupling of an acid of the general formula (II) with an amine of the general formula (III) in the presence of an amide coupling reagent such as T3P, dicyclohexylcarbodiimide, N- (3-dimethylaminopropyl ) -N '-ethylcarbodiimid, N, N' -Cabonyldiimidazol, 2-chloro-l, 3-dimethyl-imidazolium chloride or 2-chloro-l-methylpyridinium iodide (see Chemistry of peptide Synthsis, Ed. N.
  • Polymer-bound reagents such as polymer-bound dicyclohexylcarbodiimide are also suitable for this coupling reaction.
  • the reaction preferably takes place in the temperature range between 0 ° C and 80 ° C, in an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate and in the presence of a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1).
  • an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate
  • a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1).
  • the synthesis of the acid of the general formula (II) can be prepared by saponification of the compound of the general formula (IV) according to or analogously to methods known to those skilled in the art.
  • the saponification can be carried out in the presence of a base or a Lewis acid.
  • the base may be a hydroxide salt of an alkali metal (such as lithium, sodium or potassium), and the saponification reaction preferably takes place in the temperature range between room temperature and 100 ° C.
  • the Lewis acid may be boron tribromide and the reaction carried out in a temperature range between -20 ° C and 100 ° C, preferably -5 ° C and 50 ° C.
  • R ' (C 1 -C 4 ) -alkyl.
  • the synthesis of the compound of the general formula (IV) can be prepared by alkylating the compound of the general formula (V) with a halide of the general formula (VI) in the presence of a base or by methods analogous to those skilled in the art (see Scheme 3).
  • the base can be Carbonate salt of an alkali metal (such as lithium, sodium, potassium or cesium), and the saponification reaction preferably occurs in the temperature range
  • R ' (C 1 -C 4 ) -alkyl.
  • Scheme 4 describes the synthesis of the compound of general formula (V) by reaction of an enamine of general formula (VII) with a hydrazine of general formula (VIII) in an adequate solvent such as methanol or ethanol. Alternatively, the reaction may be carried out in a solvent such as tetrahydrofuran.
  • the compounds of the general formula (VII) can be prepared by condensation of a ketone of the general formula (IX) and dimethylformamide dimethyl acetal of the general formula (X) (see Scheme 5, Tetrahedron 1998, 54 (20), 5075-5088).
  • the compounds of the general formula (XVI) can be prepared by condensation of a ketone of the general formula (XV) and dimethylformamide dimethyl acetal of the general formula (X) (see Scheme 9, Tetrahedron 1998, 54 (20), 5075-5088).
  • Scheme 10 describes the synthesis of the compound of general formula (XVII) by reaction of an enamine of general formula (XVI) with a hydrazine of general formula (VIII) in an adequate solvent such as methanol or ethanol. Alternatively, the reaction may be carried out in a solvent such as tetrahydrofuran.
  • the base may be a carbonate salt of an alkali metal (such as lithium, sodium, potassium or cesium), and the saponification reaction preferably takes place in the temperature range between room temperature and 150 ° C in an adequate solvent such as, for example
  • R ' (C 1 -C 4 ) -alkyl.
  • the synthesis of the acid of general formula (XXI) can be prepared by saponification of the compound of general formula (XX) or analogously to methods known to those skilled in the art.
  • the saponification can be carried out in the presence of a base or a Lewis acid.
  • the base may be a hydroxide salt of an alkali metal (such as lithium, sodium or potassium), and the saponification reaction preferably takes place in the temperature range between room temperature and 100 ° C.
  • the Lewis acid may be boron tribromide, and the reaction may be carried out in a temperature range between -20 ° C and 100 ° C, preferably -5 ° C and 50 ° C.
  • R ' (C 1 -C 4 ) -alkyl.
  • Polymer-bound reagents such as polymer-bound dicyclohexylcarbodiimide are also suitable for this coupling reaction.
  • the reaction preferably takes place in the temperature range between 0 ° C and 80 ° C, in an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate and in the presence of a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1).
  • an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate
  • a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1).
  • 3-Fluoropyridine-2-carbonitrile (8.0 g, 65.52 mmol, 1.0 equiv) was dissolved in diethyl ether (150 ml) under a nitrogen atmosphere and cooled to 0 ° C with an ice-bath. To the solution was added dropwise within 30 min. add a 3M methylmagnesium bromide solution in diethyl ether (24.02mL, 72.07mmol). The resulting reaction mixture was stirred at room temperature overnight.
  • the suspension was cooled to 0 to 4 ° C. with an ice bath, mixed with 2M hydrochloric acid and stirred for 2 hours at room temperature. Thereafter, the pH was reduced by adding conc. Ammonia adjusted to pH 8. The reaction mixture was washed three times with 100 ml each time
  • reaction mixture was poured into water (50 ml) and extracted three times with 20 ml of ethyl acetate each time. Then the solvent was removed in vacuo and the residue was purified
  • Synthesis step 7 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (1.46-167)
  • reaction mixture was diluted with saturated sodium bicarbonate solution (10 ml) and then extracted with ethyl acetate (10 ml).
  • ethyl acetate 10 ml
  • the aqueous phase was extracted three times with ethyl acetate (10 ml) and the combined organic phases were dried over magnesium sulfate.
  • Cyclopropylacetic acid (23.00 g, 230 mmol, 1.0 equiv) was dissolved in dichloromethane (800 ml) and then treated with cabonyldiimidazole (CDI, 40.27 g, 248 mmol, 1.08 equiv.) Under nitrogen atmosphere. The reaction mixture was stirred for 2 h at room temperature and then admixed with N-methoxymethanamine hydrochloride (1: 1) (22.88 g, 234 mmol, 1.02 equiv.).
  • CDI cabonyldiimidazole
  • reaction mixture was stirred for 16 h at room temperature and then with ice water and
  • Synthesis step 2 2-Cyclopropyl-1- (2,6-difluorophenyl) ethanone 1,3-Difluorobenzene (7.50 g, 65.78 mmol, 1.0 equiv) was dissolved in THF (75 mL) and cooled to -78 ° C with a cold bath (nitrogen atmosphere). A 2M LDA solution (2M in THF, 65.5 mL, 98.67 mmol, 1.50 equiv.) was added dropwise.
  • reaction mixture was poured into water (100 ml) and extracted three times with 100 ml of ethyl acetate each time.
  • Table L I Preferred compounds of the formula (L I) are the compounds 1.1-1 to 1.1-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.1-1 to 1.1-400 of Table LI are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.2 Preferred compounds of the formula (1.2) are the compounds 1.2-1 to 1.2-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.2-1 to 1.2- 400 of Table 1.2 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.3 Preferred compounds of the formula (1.3) are the compounds 1.3-1 to 1.3-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.3-1 to 1.3-400 of Table 1.3 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.4 Preferred compounds of the formula (1.4) are the compounds 1.4-1 to 1.4-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.4-1 to 1.4-400 of Table 1.4 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.5 Preferred compounds of the formula (1.5) are the compounds 1.5-1 to 1.5-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.5-1 to 1.5-346 of Table 1.5 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.6 Preferred compounds of the formula (1.6) are the compounds 1.6-1 to 1.6-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.6-1 to 1.6-400 of Table 1.6 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.7 Preferred compounds of the formula (1.7) are the compounds 1.7-1 to 1.7-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.7-1 to 1.7-400 of Table 1.7 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.8 Preferred compounds of the formula (1.8) are the compounds 1.8-1 to 1.8-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.8-1 to 1.8-400 of Table 1.8 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.9 Preferred compounds of the formula (1.9) are the compounds 1.9-1 to 1.9-400, wherein Z has the meaning given in the respective line of Table 1.
  • the compounds 1.9-1 to 1.9-400 of Table 1.9 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.10 Preferred compounds of the formula (1.10) are the compounds 1.10-1 to 1.10-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.10-1 to 1.10-400 of Table 1.10 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.11 Preferred compounds of the formula (1.11) are the compounds 1.11 - 1 to 1.11 -400, in which Z has the meanings of Table 1 given in the respective line.
  • the compounds LI 1-1 to LI 1-400 of Table LI 1 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.12 Preferred compounds of the formula (1.12) are the compounds 1.12-1 to 1.12-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.12-1 to 1.12-400 of Table 1.12 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.13 Preferred compounds of the formula (1.13) are the compounds 1.13-1 to 1.13-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.13-1 to 1.13-400 of Table 1.13 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.14 Preferred compounds of the formula (1.14) are the compounds 1.14-1 to 1.14-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.14-1 to 1.14-400 of Table 1.14 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.15 Preferred compounds of the formula (1.15) are the compounds 1.15-1 to 1.15-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.15-1 to 1.15-400 of Table 1.15 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.16 Preferred compounds of the formula (1.16) are the compounds 1.16-1 to 1.16-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.16-1 to 1.16-400 of Table 1.16 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.17 Preferred compounds of the formula (1.17) are the compounds 1.17-1 to 1.17-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.17-1 to 1.17-400 of Table 1.17 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.18 Preferred compounds of the formula (1.18) are the compounds 1.18-1 to 1.18-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.18-1 to 1.18-400 of Table 1.18 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.19 Preferred compounds of the formula (1.19) are the compounds 1.19-1 to 1.19-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.19-1 to 1.19-400 of Table 1.19 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.20 Preferred compounds of the formula (1.20) are the compounds 1.20-1 to 1.20-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.20-1 to 1.20-400 of Table 1.20 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.21 Preferred compounds of the formula (1.21) are the compounds 1.21-1 to 1.21 -400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.21-1 to 1.21-400 of Table 1.21 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.22 Preferred compounds of the formula (1.22) are the compounds 1.22-1 to 1.22-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.22-1 to 1.22-400 of Table 1.22 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.23 Preferred compounds of the formula (1.23) are the compounds 1.23-1 to 1.23-400, in which Z has the meanings given in Table 1 in the respective line.
  • the compounds 1.23-1 to 1.23-400 of Table 1.23 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.24 Preferred compounds of the formula (1.24) are the compounds 1.24-1 to 1.24-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.24-1 to 1.24-400 of Table 1.24 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.25 Preferred compounds of the formula (1.25) are the compounds 1.25-1 to 1.25-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.25-1 to 1.25-400 of Table 1.25 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.26 Preferred compounds of the formula (1.26) are the compounds 1.26-1 to 1.26-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.26-1 to 1.26-400 of Table 1.26 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.27 Preferred compounds of the formula (1.27) are the compounds 1.27-1 to 1.27-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.27-1 to 1.27-400 of Table 1.27 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.28 Preferred compounds of the formula (1.28) are the compounds 1.28-1 to 1.28-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.28-1 to 1.28-400 of Table 1.28 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.29 Preferred compounds of the formula (1.29) are the compounds 1.29-1 to 1.29-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.29-1 to 1.29-400 of Table 1.29 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.30 Preferred compounds of the formula (1.30) are the compounds 1.30-1 to 1.30-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.30-1 to 1.30-400 of Table 1.30 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.31 Preferred compounds of the formula (1.31) are the compounds 1.31-1 to 1.31-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.31-1 to 1.31-400 of Table 1.31 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.32 Preferred compounds of the formula (1.32) are the compounds 1.32-1 to 1.32-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.32-1 to 1.32-400 of Table 1.32 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.33 Preferred compounds of the formula (1.33) are the compounds 1.33-1 to 1.33-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.33-1 to 1.33-400 of Table 1.33 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.34 Preferred compounds of the formula (1.34) are the compounds 1.34-1 to 1.34-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.34-1 to 1.34-400 of Table 1.34 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.35 Preferred compounds of the formula (1.35) are the compounds 1.35-1 to 1.35-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.35-1 to 1.35-400 of Table 1.35 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.36 Preferred compounds of the formula (1.36) are the compounds 1.36-1 to 1.36-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.36-1 to 1.36-400 of Table 1.36 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.37 Preferred compounds of the formula (1.37) are the compounds 1.37-1 to 1.37-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.37-1 to 1.37-400 of Table 1.37 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.38 Preferred compounds of the formula (1.38) are the compounds 1.38-1 to 1.38-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.38-1 to 1.38-400 of Table 1.38 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.39 Preferred compounds of the formula (1.39) are the compounds 1.39-1 to 1.39-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.39-1 to 1.39-400 of Table 1.39 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.40 Preferred compounds of the formula (1.40) are the compounds 1.40-1 to 1.40-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.40-1 to 1.40-400 of Table 1.40 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.41 Preferred compounds of the formula (1.41) are the compounds 1.41-1 to 1.41-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.41-1 to 1.41-400 of Table 1.41 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.42 Preferred compounds of the formula (1.42) are the compounds 1.42-1 to 1.42-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.42-1 to 1.42-400 of Table 1.42 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.43 Preferred compounds of the formula (1.43) are the compounds 1.43-1 to 1.43-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.43-1 to 1.43-400 of Table 1.43 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.44 Preferred compounds of the formula (1.44) are the compounds 1.44-1 to 1.44-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.44-1 to 1.44-400 of Table 1.44 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.45 Preferred compounds of the formula (1.45) are the compounds 1.45-1 to 1.45-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.45-1 to 1.45-400 of Table 1.45 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.46 Preferred compounds of the formula (1.46) are the compounds 1.46-1 to 1.46-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.46-1 to 1.46-400 of Table 1.46 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.47 Preferred compounds of the formula (1.47) are the compounds 1.47-1 to 1.47-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.47-1 to 1.47-400 of Table 1.47 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.48 Preferred compounds of the formula (1.48) are the compounds 1.48-1 to 1.48-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.48-1 to 1.48-400 of Table 1.48 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.49 Preferred compounds of the formula (1.49) are the compounds 1.49-1 to 1.49-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.49-1 to 1.49-400 of Table 1.49 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.50 Preferred compounds of the formula (1.50) are the compounds 1.50-1 to 1.50-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.50-1 to 1.50-400 of Table 1.50 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.51 Preferred compounds of the formula (1.51) are the compounds 1.51-1 to 1.51-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.51-1 to 1.51-400 of Table 1.51 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.52 Preferred compounds of the formula (1.52) are the compounds 1.52-1 to 1.52-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.52-1 to 1.52-400 of Table 1.52 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.53 Preferred compounds of the formula (1.53) are the compounds 1.53-1 to 1.53-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.53-1 to 1.53-400 of Table 1.53 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.54 Preferred compounds of the formula (1.54) are the compounds 1.54-1 to 1.54-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.54-1 to 1.54-400 of Table 1.54 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.55 Preferred compounds of the formula (1.55) are the compounds 1.1-55 to I. 55-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.55-1 to 1.55-400 of Table 1.55 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.56 Preferred compounds of the formula (1.56) are the compounds 1.56-1 to 1.56-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.56-1 to 1.56-400 of Table 1.56 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.57 Preferred compounds of the formula (1.57) are the compounds 1.57-1 to 1.57-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.57-1 to 1.57-400 of Table 1.57 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.58 Preferred compounds of the formula (1.58) are the compounds 1.58-1 to 1.58-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.58-1 to 1.58-400 of Table 1.58 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.59 Preferred compounds of the formula (1.59) are the compounds 1.59-1 to 1.59-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.59-1 to 1.59-346 of Table 1.59 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.60 Preferred compounds of the formula (1.60) are the compounds 1.60-1 to 1.60-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.60-1 to 1.60-400 of Table 1.60 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.61 Preferred compounds of the formula (1.61) are the compounds 1.61-1 to 1.61-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.61-1 to 1.61-400 of Table 1.61 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.62 Preferred compounds of the formula (1.62) are the compounds 1.62-1 to 1.62-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.62-1 to 1.62-400 of Table 1.62 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.63 Preferred compounds of the formula (1.63) are the compounds 1.63-1 to 1.63-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.63-1 to 1.63-400 of Table 1.63 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.64 Preferred compounds of the formula (1.64) are the compounds 1.64-1 to 1.64-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.64-1 to 1.64-400 of Table 1.64 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.65 Preferred compounds of the formula (1.65) are the compounds 1.1-65 to I 65-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.65-1 to 1.65-400 of Table 1.65 are thus affected by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.66 Preferred compounds of the formula (1.66) are the compounds 1.66-1 to 1.66-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.66-1 to 1.66-400 of Table 1.66 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.67 Preferred compounds of the formula (1.67) are the compounds 1.67-1 to 1.67-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.67-1 to 1.67-400 of Table 1.67 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.68 Preferred compounds of the formula (1.68) are the compounds 1.68-1 to 1.68-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.68-1 to 1.68-400 of Table 1.68 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.69 Preferred compounds of the formula (1.69) are the compounds 1.69-1 to 1.69-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.69-1 to 1.69-346 of Table 1.69 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.70 Preferred compounds of the formula (1.70) are the compounds 1.70-1 to 1.70-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.70-1 to 1.70-400 of Table 1.70 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.71 Preferred compounds of the formula (1.71) are the compounds 1.71-1 to 1.71-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.71-1 to 1.71-400 of Table 1.71 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.72 Preferred compounds of the formula (1.72) are the compounds 1.72-1 to 1.72-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.72-1 to 1.72-400 of Table 1.72 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above,
  • Table 1.73 Preferred compounds of the formula (1.73) are the compounds 1.73-1 to 1.73-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.73-1 to 1.73-400 of Table 1.73 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.74 Preferred compounds of the formula (1.74) are the compounds 1.74-1 to 1.74-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.74-1 to 1.74-400 of Table 1.74 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.75 Preferred compounds of the formula (1.75) are the compounds 1.1-75 to I 75-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.75-1 to 1.75-400 of Table 1.75 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.76 Preferred compounds of the formula (1.76) are the compounds 1.76-1 to 1.76-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.76-1 to 1.76-400 of Table 1.76 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.77 Preferred compounds of the formula (1.77) are the compounds 1.77-1 to 1.77-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.77-1 to 1.77-400 of Table 1.77 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.78 Preferred compounds of the formula (1.78) are the compounds 1.78-1 to 1.78-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.78-1 to 1.78-400 of Table 1.78 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.79 Preferred compounds of the formula (1.79) are the compounds 1.79-1 to 1.79-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.79-1 to 1.79-346 of Table 1.79 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.80 Preferred compounds of the formula (1.80) are the compounds 1.80-1 to 1.80-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.80-1 to 1.80-400 of Table 1.80 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.81 Preferred compounds of the formula (1.81) are the compounds 1.81-1 to 1.81-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.81-1 to 1.81-400 of Table 1.81 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.82 Preferred compounds of the formula (1.82) are the compounds 1.82-1 to 1.82-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.82-1 to 1.82-400 of Table 1.82 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.83 Preferred compounds of the formula (1.83) are the compounds 1.83-1 to 1.83-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.83-1 to 1.83-400 of Table 1.83 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.84 Preferred compounds of the formula (1.84) are the compounds 1.84-1 to 1.84-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.84-1 to 1.84-400 of Table 1.84 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.85 Preferred compounds of the formula (1.85) are the compounds 1.1-85 to I 85-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.85-1 to 1.85-400 of Table 1.85 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.86 Preferred compounds of the formula (1.86) are the compounds 1.86-1 to 1.86-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.86-1 to 1.86-400 of Table 1.86 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.87 Preferred compounds of the formula (1.87) are the compounds 1.87-1 to 1.87-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.87-1 to 1.87-400 of Table 1.87 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.88 Preferred compounds of the formula (1.88) are the compounds 1.88-1 to 1.88-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.88-1 to 1.88-400 of Table 1.88 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.89 Preferred compounds of the formula (1.89) are the compounds 1.89-1 to 1.89-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.89-1 to 1.89-346 of Table 1.89 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.90 Preferred compounds of the formula (1.90) are the compounds 1.90-1 to 1.90-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.90-1 to 1.90-400 of Table 1.90 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.91 Preferred compounds of the formula (1.91) are the compounds 1.91-1 to 1.91-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.91-1 to 1.91-400 of Table 1.91 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.92 Preferred compounds of the formula (1.92) are the compounds 1.92-1 to 1.92-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.92-1 to 1.92-400 of Table 1.92 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.93 Preferred compounds of the formula (1.93) are the compounds 1.93-1 to 1.93-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.93-1 to 1.93-400 of Table 1.93 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.94 Preferred compounds of the formula (1.94) are the compounds 1.94-1 to 1.94-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.94-1 to 1.94-400 of Table 1.94 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.95 Preferred compounds of the formula (1.95) are the compounds 1.95-1 to 1.95-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.95-1 to 1.95-400 of Table 1.95 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.96 Preferred compounds of the formula (1.96) are the compounds 1.96-1 to 1.96-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.96-1 to 1.96-400 of Table 1.96 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.97 Preferred compounds of the formula (1.97) are the compounds 1.97-1 to 1.97-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.97-1 to 1.97-400 of Table 1.97 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.98 Preferred compounds of the formula (1.98) are the compounds 1.98-1 to 1.98-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.98-1 to 1.98-400 of Table 1.98 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.99 Preferred compounds of the formula (1.99) are the compounds 1.99-1 to 1.99-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.99-1 to 1.99-346 of Table 1.99 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Preferred compounds of the formula (I00) are the compounds 11006-1 to 1100-400, in which Z has the meanings given in Table 1 in the respective line.
  • the compounds 1.100-1 to 1.100-400 of Table 1.100 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.101 Preferred compounds of the formula (1.101) are the compounds 1.101-1 to 1.101-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.101-1 to 1.101-400 of Table 1.101 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.102 Preferred compounds of the formula (1.102) are the compounds 1.102-1 to 1.102-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the connection 1.102-1 to 1.102-400 of Table 1.102 are thus defined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.103 Preferred compounds of the formula (1.103) are the compounds 1.103-1 to 1.103-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.103-1 to 1.1039-400 of Table 1.103 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.104 Preferred compounds of the formula (1.104) are the compounds 1.104-1 to 1.104-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.104-1 to 1.104-400 of Table 1.104 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.105 Preferred compounds of the formula (1.105) are the compounds 1.105-1 to 1.105-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.105-1 to 1.105-400 of Table 1.105 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.106 Preferred compounds of the formula (1.106) are the compounds 1.106-1 to 1.106-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection 1.106-1 to 1.106-400 of Table 1.106 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.107 Preferred compounds of the formula (1.107) are the compounds 1.107-1 to 1.107-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.107-1 to 1.107-400 of Table 1.107 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.108 Preferred compounds of the formula (1.108) are the compounds 1.108-1 to 1.108-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.108-1 to 1.108-400 of Table 1.108 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.109 Preferred compounds of the formula (1.109) are the compounds 1.109-1 to 1.109-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.109-1 to 1.109-400 of Table 1.109 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.110 Preferred compounds of the formula (1.110) are the compounds L I 10-1 to L I 10-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compound L I 10-1 to L I 10-400 of the table LI 10 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.111 Preferred compounds of the formula (1.111) are the compounds I. ll ll to 1.111-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the compound I. ll ll to 1.111-400 of Table 1.111 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.112 Preferred compounds of the formula (1.112) are the compounds L I 12-1 to L I 12-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the connection L I 12-1 to L I 12-400 of the table LI 12 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table LI 13 Preferred compounds of the formula (LI 13) are the compounds LI 13-1 to LI 13-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection LI 13-1 to LI 13-400 of the table LI 13 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.114 Preferred compounds of the formula (1.114) are the compounds 1.114-1 to 1.114-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compound L I 14-1 to L I 14-400 of the table L I 14 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.115 Preferred compounds of the formula (1.115) are the compounds 1.115-1 to 1.115-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the connection LI 15-1 to LI 15-400 of the table LI 15 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Preferred compounds of the formula (L I 16) are the compounds L I 16-1 to L I 16-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compound L I 16-1 to L I 16-400 of Table L I 16 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Preferred compounds of the formula (LI 17) are the compounds 1.117-1 to 1.117-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection LI 17-1 to LI 17-400 of Table LI 17 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.118 Preferred compounds of the formula (1.118) are the compounds 1.118-1 to 1.118-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compound L I 18-1 to L I 18-400 of the table L I 18 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table LI 19 Preferred compounds of the formula (LI 19) are the compounds LI 19-1 to LI 19-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection LI 19-1 to LI 19-400 of the table LI 19 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.120 Preferred compounds of the formula (1.120) are the compounds 1,120-1 to 1,120-400, in which Z has the meanings given in Table 1 of each line.
  • the connection 1.120-1 to 1.120-400 of Table 1.120 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.121 Preferred compounds of the formula (1.121) are the compounds 1.121-1 to 1.121-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.121-1 to 1.121-400 of Table 1.121 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.122 Preferred compounds of the formula (1.122) are the compounds 1.122-1 to 1.122-400, wherein Z has the meanings given in Table 1 of each line.
  • the connection 1.122-1 to 1.122-400 of Table 1.122 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.123 Preferred compounds of the formula (1.123) are the compounds 1.123-1 to 1.123-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.123-1 to 1.123-400 of Table 1.123 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.124 Preferred compounds of the formula (1.124) are the compounds 1.124-1 to 1.124-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.124-1 to 1.124-400 of Table 1.124 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.125 Preferred compounds of the formula (1.125) are the compounds 1.125-1 to 1.125-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection 1.125-1 to 1.125-400 of Table 1.125 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.126 Preferred compounds of the formula (1.126) are the compounds 1.126-1 to 1.126-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.126-1 to 1.126-400 of Table 1.126 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.127 Preferred compounds of the formula (1.127) are the compounds 1.127-1 to 1.127-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.127-1 to 1.127-400 of Table 1.127 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.128 Preferred compounds of the formula (1.128) are the compounds 1.128-1 to 1.128-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.128-1 to 1.128-400 of Table 1.128 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.129 Preferred compounds of the formula (1.129) are the compounds 1.129-1 to 1.129-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.129-1 to 1.129-400 of Table 1.129 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.130 Preferred compounds of the formula (1.130) are the compounds 1.130-1 to 1.130-400, in which Z has the meanings given in Table 1 of each line.
  • the compounds 1.130-1 to 1.130-400 of Table 1.130 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.131 Preferred compounds of the formula (1.131) are the compounds 1.131-1 to 1.131-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.131-1 to 1.131-400 of Table 1.131 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.132 Preferred compounds of the formula (1.132) are the compounds 1.132-1 to 1.132-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.132-1 to 1.132-400 of Table 1.132 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.133 Preferred compounds of the formula (1.133) are the compounds 1.133-1 to 1.133-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.133-1 to 1.133-400 of Table 1.133 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.134 Preferred compounds of the formula (1.134) are the compounds 1.134-1 to 1.134-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.134-1 to 1.134-400 of Table 1.134 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.135 Preferred compounds of the formula (1.135) are the compounds 1.135-1 to 1.135-400, wherein Z has the meanings indicated in the respective line of Table 1.
  • the compounds 1.135-1 to 1.135-400 of Table 1.135 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.136 Preferred compounds of the formula (1.136) are the compounds 1.136-1 to 1.136-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.136-1 to 1.136-400 of Table 1.136 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.137 Preferred compounds of the formula (1.137) are the compounds 1.137-1 to 1.137-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.137-1 to 1.137-400 of Table 1.137 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.138 Preferred compounds of the formula (1.138) are the compounds 1.138-1 to 1.138-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.138-1 to 1.138-400 of Table 1.138 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.139 Preferred compounds of the formula (1.139) are the compounds 1.139-1 to 1.139-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.139-1 to 1.139-400 of Table 1.139 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.140 Preferred compounds of the formula (1.140) are the compounds 1.140-1 to 1.140-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the connection 1.140-1 to 1.140-400 of Table 1.140 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.141 Preferred compounds of the formula (1.141) are the compounds 1.141-1 to 1.141-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.141-1 to 1.141-400 of Table 1.141 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.142 Preferred compounds of the formula (1.142) are the compounds 1.142-1 to 1.142-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.142-1 to 1.142-400 of Table 1.142 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.143 Preferred compounds of the formula (1.143) are the compounds 1.143-1 to 1.143-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.143-1 to 1.143-400 of Table 1.143 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.144 Preferred compounds of the formula (1.144) are the compounds 1.144-1 to 1.144-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.144-1 to 1.144-400 of Table 1.144 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.145 Preferred compounds of the formula (1.145) are the compounds 1.145-1 to 1.145-400, wherein Z has the meanings given in Table 1 of each Table.
  • the connection 1.145-1 to 1.145-400 of Table 1.145 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.146 Preferred compounds of the formula (1.146) are the compounds 1.146-1 to 1.146-400, wherein Z has the meaning given in the respective line of Table 1.
  • the compounds 1.146-1 to 1.146-400 of Table 1.146 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.147 Preferred compounds of the formula (1.147) are the compounds 1.147-1 to 1.147-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.147-1 to 1.147-400 of Table 1.147 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.148 Preferred compounds of the formula (1.148) are the compounds 1.48-1 to 1.148-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.148-1 to 1.148-400 of Table 1.148 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.149 Preferred compounds of the formula (1.149) are the compounds 1.149-1 to 1.149-400, wherein Z has the meaning given in the respective line of Table 1.
  • the compounds 1.149-1 to 1.149-400 of Table 1.85 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.150 Preferred compounds of the formula (1.150) are the compounds 1.150-1 to 1.150-400, in which Z has the meanings of Table 1 indicated in the respective line.
  • the connection 1.150-1 to 1.150-400 of Table 1.150 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.151 Preferred compounds of the formula (1.151) are the compounds 1.151-1 to 1.151-400, wherein Z has the meanings given in Table 1 of each line.
  • the compounds 1.151-1 to 1.151-400 of Table 1.151 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.152 Preferred compounds of the formula (1.152) are the compounds 1.152-1 to 1.152-400, wherein Z has the meanings given in Table 1 of each line.
  • the connection 1.152-1 to 1.152-400 of Table 1.152 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.153 Preferred compounds of the formula (1.153) are the compounds 1.153-1 to 1.153-400, wherein Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.153-1 to 1.153-400 of Table 1.153 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.154 Preferred compounds of the formula (1.154) are the compounds 1.154-1 to 1.154-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.154-1 to 1.154-400 of Table 1.154 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.155 Preferred compounds of the formula (1.155) are the compounds 1.155-1 to 1.155-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection 1.155-1 to 1.155-400 of Table 1.155 are thus determined by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.156 Preferred compounds of the formula (1.156) are the compounds 1.156-1 to 1.156-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.156-1 to 1.156-400 of Table 1.156 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.157 Preferred compounds of the formula (1.157) are the compounds 1.157-1 to 1.157-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.157-1 to 1.157-400 of Table 1.157 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.158 Preferred compounds of the formula (1.158) are the compounds 1.158-1 to 1.158-400, wherein Z has the meanings of Table 1 given in the respective line.
  • the compounds 1.158-1 to 1.158-400 of Table 1.158 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.159 Preferred compounds of the formula (1.159) are the compounds 1.159-1 to 1.159-400, wherein Z has the meanings given in Table 1 of each Table.
  • the compounds 1.159-1 to 1.159-400 of Table 1.159 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
  • Table 1.160 Preferred compounds of the formula (1.160) are the compounds 1.160-1 to 1.160-400, wherein Z has the meaning given in the respective line of Table 1.
  • the connection 1.160-1 to 1.160-400 of Table 1.160 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
  • Table 1.161 Preferred compounds of the formula (1.161) are the compounds 1.161-1 to 1.161-400, wherein Z has the meanings of Table 1 indicated in the respective line.
  • the compounds 1.161-1 to 1.161-400 of Table 1.161 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

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Abstract

La présente invention concerne des pyrazoles substitués de formule générale (I) ou leurs sels, les fractions de la formule générale (I) ayant les définitions figurant dans le descriptif, ainsi que leur utilisation comme herbicides, en particulier pour lutter contre les plantes adventices et/ou les mauvaises herbes dans les cultures de plantes utiles et/ou comme régulateurs de croissance des plantes pour influencer la croissance des cultures de plantes utiles.The present invention relates to substituted pyrazoles of the general formula (I) or their salts, the fractions of the general formula (I) having the definitions given in the description, as well as their use as herbicides, in particular for the control of weeds and plants. or weeds in useful plant cultures and / or as plant growth regulators to influence the growth of useful plant crops.

Description

Substituierte Pyrazole sowie deren Salze und ihre Verwendung als herbizide Wirkstoffe Beschreibung  Substituted pyrazoles and their salts and their use as herbicidal active substances Description

Die Erfindung betrifft das technische Gebiet der Pflanzenschutzmittel, insbesondere das der Herbizide zur selektiven Bekämpfung von Unkräutern und Ungräsern in Nutzpflanzenkulturen. Speziell betrifft diese Erfindung substituierte Pyrazole sowie deren Salze, Verfahren zu ihrer The invention relates to the technical field of crop protection agents, in particular that of herbicides for the selective control of weeds and grass weeds in crops. Specifically, this invention relates to substituted pyrazoles and their salts, to processes for their

Herstellung und ihre Verwendung als Herbizide. Production and their use as herbicides.

Bisher bekannte Pflanzenschutzmittel zur selektiven Bekämpfung von Schadpflanzen in Previously known crop protection agents for the selective control of harmful plants in

Nutzpflanzenkulturen oder Wirkstoffe zur Bekämpfung von unerwünschtem Pflanzenwuchs weisen bei ihrer Anwendung teilweise Nachteile auf, sei es, dass sie (a) keine oder aber eine unzureichende herbizide Wirkung gegen bestimmte Schadpflanzen, (b) ein zu geringes Spektrum der Schadpflanzen, das mit einem Wirkstoff bekämpft werden kann, (c) zu geringe Selektivität in Nutzpflanzenkulturen und/oder (d) ein toxikologisch ungünstiges Profil besitzen. Weiterhin führen manche Wirkstoffe, die als Pflanzenwachstumsregulatoren bei einigen Nutzpflanzen eingesetzt werden können, bei anderen Nutzpflanzen zu unerwünscht verminderten Ernteerträgen oder sind mit der Kulturpflanze nicht oder nur in einem engen Aufwandmengenbereich verträglich. Einige der bekannten Wirkstoffe lassen sich wegen schwer zugänglicher Vorprodukte und Reagenzien im industriellen Maßstab nicht wirtschaftlich herstellen oder besitzen nur unzureichende chemische Stabilitäten. Bei anderen Wirkstoffen hängt die Wirkung zu stark von Umweltbedingungen, wie Wetter- und Bodenverhältnissen ab. Commercial crops or active substances for combating undesirable plant growth have some drawbacks in their application, be it that they (a) no or insufficient herbicidal activity against certain harmful plants, (b) a too low a range of harmful plants, which fights with an active ingredient (c) have too low selectivity in crops and / or (d) have a toxicologically unfavorable profile. Furthermore, some active substances that can be used as plant growth regulators in some crops, in other crops to undesirably reduced crop yields or are compatible with the crop or only in a narrow application rate range. Some of the known active compounds can not be produced economically on the industrial scale because of difficultly accessible precursors and reagents or have only insufficient chemical stabilities. For other active ingredients the effect depends too much on environmental conditions, such as weather and soil conditions.

Die herbizide Wirkung dieser bekannten Verbindungen, insbesondere bei niedrigen Aufwandmengen, bzw. deren Verträglichkeit gegenüber Kulturpflanzen bleiben verbesserungswürdig. The herbicidal action of these known compounds, in particular at low application rates, or their compatibility with crop plants, should be improved.

Verschiedene Schriften beschreiben substituierte Pyrazole mit herbiziden Eigenschaften. Aus Various documents describe substituted pyrazoles having herbicidal properties. Out

CH629364, US3957480, DE2550566, CA1053231, US4072498, US4097672, US4115649 und J. Agric. Food Chem. 1977, 25 (5), 1039-1049 sind substituierte Pyrazole bekannt, die an der Amid-Bindung Alkylgruppen tragen. CH629364, US3957480, DE2550566, CA1053231, US4072498, US4097672, US4115649 and J. Agric. Food Chem. 1977, 25 (5), 1039-1049, substituted pyrazoles are known which carry alkyl groups at the amide bond.

Die Verwendung von substituierten Pyrazole oder deren Salze als herbizide Wirkstoffe, die am Pyrazol einen der definierten substituierten Phenyl-, Thiophen-, Thiazol- oder Pyrimidin-Reste tragen ist dagegen noch nicht beschrieben. Überraschenderweise wurde nun gefunden, dass substituierte Pyrazole oder deren Salze als herbizide Wirkstoffe, die am Pyrazol einen der definierten substituierten Phenyl-, Thiophen-, Thiazol- oder Pyrimidin-Reste tragen, als Herbizide besonders gut geeignet sind. The use of substituted pyrazoles or their salts as herbicidal active ingredients which carry one of the defined substituted phenyl, thiophene, thiazole or pyrimidine radicals on the pyrazole is, however, not yet described. Surprisingly, it has now been found that substituted pyrazoles or their salts as herbicidal active compounds which carry one of the defined substituted phenyl, thiophene, thiazole or pyrimidine radicals on pyrazole are particularly suitable as herbicides.

Figure imgf000003_0001
Figure imgf000003_0001

Figure imgf000003_0002
Figure imgf000003_0002

Figure imgf000003_0003
Figure imgf000003_0003

10 steht, für Wasserstoff, Halogen, Cyano, (Ci-Cg)-Alkyl, (Ci-Cg)-Haloalkyl, (Ci-Cg)-Cyanoalkyl, (Ci-Cg)-Hydroxyalkyl, (Ci-Cg)-Alkoxy-(Ci-Cg)-alkyl, (C3-Cio)-Cycloalkyl, (C3-Cio)-Cycloalkyl- (Ci-Cg)-alkyl, (C3-Cg)-Halocycloalkyl, (Ci-Cg)-Alkoxy, (Ci-Cg)-Haloalkoxy, (Ci-Cg)-Alkylthio, (Ci-Cg)-Haloalkylthio, (C3-Cg)-Cycloalkylthio, (Ci-Cg)-Alkylsulfmyl, (Ci-Cg)-Haloalkylsulfmyl, (C3-Cg)-Cycloalkylsulfinyl, (Ci-Cg)-Alkylsulfonyl, (Ci-Cg)-Haloalkylsulfonyl, (C3-Cg)- cycloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-Cio)-Alkyl und (Ci-Cio)-Haloalkyl steht, für (Ci-Cio)-Alkyl und (Ci-Cio)-Haloalkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7- gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-Cio)-Alkyl, (Ci-Cio)-Haloalkyl, (C2-Cio)-Alkenyl, (C3-Cio)-Alkynyl, (Ci-Cio)-Cyanoalkyl, (Ci-Cio)-Hydroxyalkyl, (C3-Cio)-Cycloalkyl, (C3-Cio)-Halocycloalkyl, (C3-Cio)-Cyanocycloalkyl, (C3-Cio)-Cycloalkenyl, (Ci-Cio)-Alkyl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Alkoxy-(C3-Cio)-cycloalkyl, (Ci-Cio)-Haloalkoxy-(C3-Cio)-cycloalkyl, (Ci-Cio)- Alkylthio-(C3-Cio)-cycloalkyl, Aryl-(C3-Cio)-cycloalkyl, Heteroaryl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Alkoxycarbonyl-(C3-Cio)-cycloalkyl, Hydroxcarbonyl-(C3-Cio)-cycloalkyl, (C3-C10)- Cycloalkyl-(C3-Cio)-cycloalkyl, (C3-Cio)-cycloalkyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkyloxy, (Ci- Cio)-Alkylamino, (Ci-Cio)-Haloalkyloxy, (Ci-Cio)-Haloalkylamino, (Ci-Cio)-Cycloalkyloxy, (Ci-Cio)-Cycloalkylamino, (Ci-Cio)-Alkylthio-(Ci-Cio)-alkyl, (Ci-Cio)-Alkylsulfinyl-(Ci-Cio)- alkyl, (Ci-Cio)-Alkyltsulfonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkoxy-(Ci-Cio)- alkyl, (C1-C10)- Haloalkoxy-(Ci-Cio)-alkyl, Hydroxy-(Ci-Cio)-alkyl, Hydrothio-(Ci-Cio)-alkyl, Heterocyclyl- (Ci-Cio)-alkyl, Aryl-(Ci-Cio)-alkyl, Heteroaryl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkyldisulfanediyl- (Ci-Cio)-alkyl, (Ci-Cio)-Alkoxycarbonyl-(Ci-Cio)-alkyl, Hyroxycarbonyl-(Ci-Cio)-alkyl, Aminocarbonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkoxycarbonyl-(C3-Cio)-cycloalkyl, 10 is hydrogen, halogen, cyano, (Ci-Cg) -alkyl, (Ci-Cg) -haloalkyl, (Ci-Cg) -cyanoalkyl, (Ci-Cg) -hydroxyalkyl, (Ci-Cg) -alkoxy- ( Ci-Cg) -alkyl, (C 3 -Cio) -cycloalkyl, (C 3 -Cio) -cycloalkyl (Ci-Cg) -alkyl, (C 3 -Cg) -Halocycloalkyl, (Ci-Cg) -alkoxy, (Ci-Cg) -haloalkoxy, (Ci-Cg) -alkylthio, (Ci-Cg) -haloalkylthio, (C 3 -Cg) -cycloalkylthio, (Ci-Cg) -alkylsulfmyl, (Ci-Cg) -haloalkylsulfmyl, ( C 3 -Cg) -cycloalkylsulfinyl, (Ci-Cg) -alkylsulfonyl, (Ci-Cg) -haloalkylsulfonyl, (C 3 -Cg) -cycloalkylsulfonyl, represents oxygen or sulfur, for (Ci-Cio) -alkyl and ( Ci-Cio) -haloalkyl, (Ci-Cio) -alkyl and (Ci-Cio) -haloalkyl, or wherein R 1 and R 2 together with the carbon atom to which they are each bonded, a fully saturated , or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S interrupted and optionally further substituted, total 3-7-membered ring, is, for hydroxy, amino, (Ci-Cio) alkyl, (Ci -Cio) -H aloalkyl, (C 2 -Cio) alkenyl, (C 3 -Cio) alkynyl, (Ci-Cio) cyanoalkyl, (Ci-Cio) -Hydroxyalkyl, (C 3 -Cio) -cycloalkyl, (C 3 -Cio ) -Halocycloalkyl, (C 3 -Cio) -cyanocycloalkyl, (C 3 -Cio) -cycloalkenyl, (C 1 -C 10) -alkyl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -alkoxy- (C 3 -Cio) -cycloalkyl, (Ci-Cio) -haloalkoxy- (C 3 -Cio) -cycloalkyl, (Ci-Cio) - alkylthio (C 3 -Cio) -cycloalkyl, aryl- (C 3 -Cio) -cycloalkyl , heteroaryl (C 3 -Cio) cycloalkyl, (Ci-Cio) alkoxycarbonyl (C 3 -Cio) cycloalkyl, Hydroxcarbonyl- (C 3 -Cio) cycloalkyl, (C3-C10) - cycloalkyl (C 3- Cio) -cycloalkyl, (C 3 -Cio) -cycloalkyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkyloxy, (C 1 -C 10) -alkylamino, (C 1 -C 10) -haloalkyloxy, (Ci -C) haloalkylamino, (C 1 -C 10) -cycloalkyloxy, (C 1 -C 10) -cycloalkylamino, (C 1 -C 10) -alkylthio (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylsulfinyl- (C 1 -C 10 -alkyl) ) - alkyl, (C 1 -C 10) -alkylsulfonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxy- (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkoxy- (C 1 -C 10) - Alkyl, hydroxy (Ci-Cio) -alkyl, hydrothio (Ci-Cio) -alkyl, heterocyclyl (Ci-Cio) -alkyl, aryl (C i-Cio) -alkyl, heteroaryl- (Ci-Cio) -alkyl, (Ci-Cio) -Alkyldisulfanediyl- (Ci-Cio) -alkyl, (Ci-Cio) -Alkoxycarbonyl- (Ci-Cio) -alkyl, Hyroxycarbonyl (C 1 -C 10) -alkyl, aminocarbonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxycarbonyl- (C 3 -C 10) -cycloalkyl,

Hydroxycarbonyl-(C3-Cio)-cycloalkyl, Aminocarbonyl-(C3-Cio)-cycloalkyl, (C1-C10)- Alkylaminocarbonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Dialkylaminocarbonyl-(Ci-Cio)-alkyl, (C1-C10)- Alkylaminocarbonyl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Dialkylaminocarbonyl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Alkylsulfonyl, (Ci-Cio)-Haloalkylsulfonyl, (C3-Cio)-Cycloalkylsulfonyl, (C3-C10)- Halocycloalkylsulfonyl, Aminosulfonyl, (Ci-Cio)-Alkylaminosulfonyl, (C1-C10)- Dialkylaminosulfonyl, Heterocyclyl, (C3-Cio)-Cycloalkyl-(C3-Cio)-cycloalkyl, (C3-C10)- Cycloalkyl-(C3-Cio)-cycloalkyl-(C3-Cio)-Cycloalkyl-(C3-Cio)-cycloalkylalkyl, Aminosulfonyl- (Ci-Cio)-alkyl, (Ci-Cio)-Alkylaminosulfonylamino, (Ci-Cio)-Dialkylaminosulfonylamino, (Ci-Cio)-Alkoxycarbonylamino, (Ci-Cio)-Alkoxycarbonyloxy, (Ci-Cio)-Alkoxycarbonylamino- (Ci-Cio)-alkyl, (Ci-Cio)-Alkenyl, (C2-Cio)-Alkynyl steht, Hydroxycarbonyl (C 3 -Cio) cycloalkyl, aminocarbonyl (C 3 -Cio) cycloalkyl, (C 1 -C 1 0) - alkylaminocarbonyl (Ci-Cio) alkyl, (Ci-Cio) dialkylaminocarbonyl ( C 1 -C 10) -alkyl, (C 1 -C 10) -alkylaminocarbonyl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -dialkylaminocarbonyl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -alkylsulfonyl, (C 1 -C 10) -haloalkylsulfonyl, (C 3 -C 10) -cycloalkylsulfonyl, (C 3 -C 10) -halocycloalkylsulfonyl, aminosulfonyl, (C 1 -C 10) -alkylaminosulfonyl, (C 1 -C 10) -dialkylaminosulfonyl , Heterocyclyl, (C 3 -C 10) cycloalkyl- (C 3 -C 10) cycloalkyl, (C 3 -C 10) cycloalkyl- (C 3 -C 10) cycloalkyl- (C 3 -C 10) cycloalkyl- (C 3 -C 10) cycloalkylalkyl) , Aminosulfonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylaminosulfonylamino, (C 1 -C 10) -dialkylaminosulfonylamino, (C 1 -C 10) -alkoxycarbonylamino, (C 1 -C 10) -alkoxycarbonyloxy, (C 1 -C 10) -alkoxycarbonylamino - (C 1 -C 10) -alkyl, (C 1 -C 10) -alkenyl, (C 2 -C 10) -alkynyl,

R für Wasserstoff, (Ci-Cio)-Alkyl, (Ci-Cio)-Haloalkyl, (C2-Cio)-Alkenyl, (C3-Cio)-Alkynyl, R is hydrogen, (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkyl, (C 2 -C 10) -alkenyl, (C 3 -C 10) -alkynyl,

(Ci-Cio)-Alkoxy-(Ci-Cio)-alkyl, (Ci-Cio)-Haloalkoxy-(Ci-Cio)-alkyl, (Ci-Cio)-Alkylthio- (Ci-Cio)-alkyl, (Ci-Cio)-Haloalkylthio-(Ci-Cio)-alkyl, (C3-Cio)-Cycloalkyl, Hydroxy-(Ci-Cio)- alkylcarbonyl, Amino-(Ci-Cio)-alkyll, (Ci-Cio)-Alkoxycarbonyl-(Ci-Cio)-alkyl, (C1-C10)- Cyanoalkyl, (C1-C10)- Alkylthio-(Ci-Cio)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: (C 1 -C 10) -alkoxy- (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkoxy- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylthio (C 1 -C 10) -alkyl, (Ci -C) haloalkylthio (C 1 -C 10) -alkyl, (C 3 -C 10) -cycloalkyl, hydroxy- (C 1 -C 10) -alkylcarbonyl, amino- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxycarbonyl - (Ci-Cio) alkyl, (C 1 -C 1 0) - cyanoalkyl, (C1-C10) - alkylthio group is (Ci-Cio) alkyl, or R 3 and R 4 with the nitrogen atom to which are bonded to form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is, except the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]).  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).

Die Verbindungen der allgemeinen Formel (I) können durch Anlagerung einer geeigneten The compounds of general formula (I) can be prepared by addition of a suitable

anorganischen oder organischen Säure, wie beispielsweise Mineralsäuren, wie beispielsweise HCl, HBr, H2SO4, ftPO i oder HNO3, oder organische Säuren, z. B. Carbonsäuren, wie Ameisensäure, Essigsäure, Propionsäure, Oxalsäure, Milchsäure oder Salicylsäure oder Sulfonsäuren, wie zum Beispiel p- Toluolsulfonsäure, an eine basische Gruppe, wie z.B. Amino, Alkylamino, Dialkylamino, Piperidino, Morpholino oder Pyridino, Salze bilden. Diese Salze enthalten dann die konjugierte Base der Säure als Anion. Geeignete Substituenten, die in deprotonierter Form, wie z.B. Sulfonsäuren, bestimmte inorganic or organic acid, such as mineral acids such as HCl, HBr, H2SO4, ftPO.sub.i or HNO.sub.3, or organic acids, e.g. Carboxylic acids, such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid or salicylic acid, or sulfonic acids, such as p-toluenesulfonic acid, to a basic group, e.g. Amino, alkylamino, dialkylamino, piperidino, morpholino or pyridino, salts. These salts then contain the conjugate base of the acid as an anion. Suitable substituents which are in deprotonated form, e.g. Sulfonic acids, certain

Sulfonsäureamide oder Carbonsäuren, vorliegen, können innere Salze mit ihrerseits protonierbaren Gruppen, wie Aminogruppen bilden. Salzbildung kann auch durch Einwirkung einer Base auf  Sulfonsäureamide or carboxylic acids, may form internal salts with their turn protonatable groups, such as amino groups. Salt formation can also be due to the action of a base

Verbindungen der allgemeinen Formel (I) erfolgen. Geeignete Basen sind beispielsweise organische Amine, wie Trialkylamine, Morpholin, Piperidin und Pyridin sowie Ammonium-, Alkali- oder Compounds of the general formula (I) take place. Suitable bases are, for example, organic amines, such as trialkylamines, morpholine, piperidine and pyridine and ammonium, alkali or

Erdalkalimetallhydroxide, -carbonate und -hydrogencarbonate, insbesondere Natrium- und Alkaline earth metal hydroxides, carbonates and bicarbonates, in particular sodium and

Kaliumhydroxid, Natrium- und Kaliumcarbonat und Natrium- und Kaliumhydrogencarbonat. Diese Salze sind Verbindungen, in denen der azide Wasserstoff durch ein für die Landwirtschaft geeignetes Kation ersetzt wird, beispielsweise Metallsalze, insbesondere Alkalimetallsalze oder  Potassium hydroxide, sodium and potassium carbonate and sodium and potassium bicarbonate. These salts are compounds in which the azide hydrogen is replaced by a cation suitable for agriculture, for example metal salts, in particular alkali metal salts or

Erdalkalimetallsalze, insbesondere Natrium- und Kaliumsalze, oder auch Ammoniumsalze, Salze mit organischen Aminen oder quartäre Ammoniumsalze, zum Beispiel mit Kationen der Formel [NRaRbRcRd]+ worin Ra bis Rd jeweils unabhängig voneinander einen organischen Rest, insbesondere Alkyl, Aryl, Arylalkyl oder Alkylaryl darstellen. Infrage kommen auch Alkylsulfonium- und Alkaline earth metal salts, in particular sodium and potassium salts, or else ammonium salts, salts with organic amines or quaternary ammonium salts, for example with cations of the formula [NR a R b R c R d ] + wherein R a to R d are each independently an organic radical, in particular alkyl, aryl, arylalkyl or alkylaryl. Also suitable are alkylsulfonium and

Alkylsulfoxoniumsalze, wie (Ci-C4)-Trialkylsulfonium- und (Ci-C4)-Trialkylsulfoxoniumsalze.  Alkylsulfoxoniumsalze, such as (Ci-C4) -trialkylsulfonium and (Ci-C4) -Trialkylsulfoxoniumsalze.

Die erfindungsgemäßen substituierten Pyrazole der allgemeinen Formel (I) können in Abhängigkeit von äußeren Bedingungen, wie pH- Wert, Lösungsmittel und Temperatur in verschiedenen tautomeren Strukturen vorliegen, die alle von der allgemeinen Formel (I) umfasst sein sollen. Depending on external conditions, such as pH, solvent and temperature, the substituted pyrazoles of the general formula (I) according to the invention may be present in various tautomeric structures, all of which are intended to be encompassed by the general formula (I).

Im Folgenden werden die erfindungsgemäß verwendeten Verbindungen der Formel (I) und ihre Salze "Verbindungen der allgemeinen Formel (I)" bezeichnet. The compounds of the formula (I) used according to the invention and their salts are referred to below as "compounds of the general formula (I)".

Bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin Q für die Gruppen Q-l . l bis Q-7.1 Preferred subject of the invention are compounds of general formula (I), wherein Q is the groups Q-l. l to Q-7.1

Figure imgf000006_0001
Figure imgf000006_0001

steht,  stands,

Z für die Gruppe

Figure imgf000006_0002
steht, für Wasserstoff, Halogen, Cyano, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (Ci-C6)-Cyanoalkyl, (Ci-C6)-Hydroxyalkyl, (Ci-C6)-Alkoxy-(Ci-C6)-alkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl- (Ci-C6)-alkyl, (C3-C8)-Halocycloalkyl, (Ci-C6)-Alkoxy, (Ci-C6)-Haloalkoxy, (Ci-C6)-Alkylthio, (Ci-C6)-Haloalkylthio, (C3-C6)-Cycloalkylthio, (Ci-C6)-Alkylsulfmyl, (Ci-C6)-Haloalkylsulfmyl, (C3-C6)-Cycloalkylsulfinyl, (Ci-C6)-Alkylsulfonyl, (Ci-C6)-Haloalkylsulfonyl, (C3-C6)- cycloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-C6)-Alkyl und (Ci-C8)-Haloalkyl steht, für (Ci-C8)-Alkyl und (Ci-C8)-Haloalkyl, steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7- gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-C8)-Alkyl, (Ci-C8)-Haloalkyl, (C2-C8)-Alkenyl, (C3-C8)-Alkynyl, (Ci-C8)-Cyanoalkyl, (Ci-C8)-Hydroxyalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Cyanocycloalkyl, (C3-C8)-Cycloalkenyl, (Ci-C8)-Alkyl-(C3-C8)-cycloalkyl, (Ci-C8)- Alkoxy-(C3-C8)-cycloalkyl, (Ci-C8)-Haloalkoxy-(C3-C8)-cycloalkyl, (Ci-C8)-Alkylthio-(C3-C8)- cycloalkyl, Aryl-(C3-C8)-cycloalkyl, Heteroaryl-(C3-C8)-cycloalkyl, (Ci-C8)-Alkoxycarbonyl- (C3-C8)-cycloalkyl, Hydroxcarbonyl-(C3-C8)-cycloalkyl, (C3-C8)-Cycloalkyl-(C3-C8)- cycloalkyl, (C3-C8)-cycloalkyl-(Ci-C8)-alkyl, (Ci-C8)-Alkyloxy, (Ci-C8)-Alkylamino, (Ci-C8)- Haloalkyloxy, (Ci-C8)-Haloalkylamino, (Ci-C8)-Cycloalkyloxy, (Ci-C8)-Cycloalkylamino, (Ci-C8)-Alkylthio-(Ci-C8)-alkyl, (Ci-C8)-Alkylsulfmyl-(Ci-C8)-alkyl, (Ci-C8)-Alkylsulfonyl- (Ci-C8)-alkyl, (Ci-C8)-Alkoxy-(Ci-C8)-alkyl, (Ci-C8)-Haloalkoxy-(Ci-C8)-alkyl, Hydroxy- (Ci-C8)-alkyl, Hydrothio-(Ci-C8)-alkyl, Heterocyclyl-(Ci-C8)-alkyl, Aryl-(Ci-C8)-alkyl, Heteroaryl-(Ci-C8)-alkyl, (Ci-C8)-Alkyldisulfanediyl-(Ci-C8)-alkyl, (Ci-C8)-Alkoxycarbonyl- (Ci-C8)-alkyl, Hyroxycarbonyl-(Ci-C8)-alkyl, Aminocarbonyl-(Ci-C8)-alkyl, (Ci-Cs)- Alkoxycarbonyl-(C3-C8)-cycloalkyl, Hydroxycarbonyl-(C3-C8)-cycloalkyl, Aminocarbonyl- (C3-C8)-cycloalkyl, (Ci-C8)-Alkylaminocarbonyl-(Ci-C8)-alkyl, (Ci-C8)-Dialkylaminocarbonyl- (Ci-C8)-alkyl, (Ci-C8)-Alkylaminocarbonyl-(C3-C8)-cycloalkyl, (Ci-C8)-Dialkylaminocarbonyl- (C3-C8)-cycloalkyl, (Ci-C8)-Alkylsulfonyl, (Ci-C8)-Haloalkylsulfonyl, (C3-C8)- Cycloalkylsulfonyl, (C3-Cg)-Halocycloalkylsulfonyl, Aminosulfonyl, (Ci-C8)- Alkylaminosulfonyl, (Ci-C8)-Dialkylaminosulfonyl, Heterocyclyl, (C3-C8)-Cycloalkyl-(C3-Cg)- cycloalkyl, (C3-C8)-Cycloalkyl-(C3-C8)-cycloalkyl-(C3-C8)-Cycloalkyl-(C3-C8)-cycloalkylalkyl, Aminosulfonyl-(Ci-C8)-alkyl, (Ci-C8)-Alkylaminosulfonylamino, (Ci-C8)- Dialkylaminosulfonylamino, (Ci-C8)-AlkoxyCarbonylamino, (Ci-C8)-Alkoxycarbonyloxy, (Ci-C8)-Alkoxycarbonylamino-(Ci-C8)-alkyl, (Ci-Cg)-Alkenyl, (C2-C8)-Alkynyl steht, Z for the group
Figure imgf000006_0002
is hydrogen, halogen, cyano, (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, (C 1 -C 6 ) -cyanoalkyl, (C 1 -C 6 ) -hydroxyalkyl, (C 1 -C 6 ) -alkoxy (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl- (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -halocycloalkyl, ( Ci-C 6) alkoxy, (Ci-C 6) -haloalkoxy, (Ci-C 6) alkylthio, (Ci-C 6) haloalkylthio, (C 3 -C 6) -cycloalkylthio, (Ci-C 6 ) -Alkylsulfmyl, (Ci-C 6) -Haloalkylsulfmyl, (C 3 -C 6) cycloalkylsulfinyl, (Ci-C 6) alkylsulfonyl, (Ci-C 6) haloalkylsulfonyl, (C 3 -C 6) - cycloalkylsulfonyl is oxygen or sulfur, (C 1 -C 6 ) -alkyl and (C 1 -C 8 ) -haloalkyl, (C 1 -C 8 ) -alkyl and (C 1 -C 8 ) -haloalkyl, or where R 1 and R 2 together with the C-atom to which they are each bonded are a fully saturated or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, in total Form a 7-membered ring, stands for Hyd roxy, amino, (Ci-C 8) -alkyl, (Ci-C8) -haloalkyl, (C 2 -C 8) -alkenyl, (C 3 -C 8) alkynyl, (Ci-C 8) cyanoalkyl , (C 1 -C 8 ) -hydroxyalkyl, (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -halocycloalkyl, (C 3 -C 8 ) -cyanocycloalkyl, (C 3 -C 8 ) -cycloalkenyl, (Ci-C 8) alkyl (C 3 -C 8) cycloalkyl, (Ci-C8) - alkoxy (C 3 -C 8) cycloalkyl, (Ci-C8) haloalkoxy (C 3 -C 8) cycloalkyl, (Ci-C8) alkylthio (C 3 -C 8) - cycloalkyl, aryl (C 3 -C 8) cycloalkyl, heteroaryl (C 3 -C 8) cycloalkyl, (C 1 -C 8 ) -alkoxycarbonyl- (C 3 -C 8 ) -cycloalkyl, hydroxcarbonyl- (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl- (C 3 -C 8 ) -cycloalkyl , (C 3 -C 8) cycloalkyl- (Ci-C 8) alkyl, (Ci-C8) alkyloxy, (Ci-C 8) alkylamino, (Ci-C 8) - haloalkyloxy, (Ci- C 8 ) -haloalkylamino, (C 1 -C 8 ) -cycloalkyloxy, (C 1 -C 8 ) -cycloalkylamino, (C 1 -C 8 ) -alkylthio (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylsulfmyl - (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylsulfonyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkoxy- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkyl 8 ) -haloalkoxy- (C 1 -C 8 ) -alkyl, hydro xy (Ci-C 8) alkyl, Hydrothio- (Ci-C 8) alkyl, heterocyclyl (Ci-C 8) alkyl, aryl (Ci-C 8) alkyl, heteroaryl (Ci-C 8 ) -alkyl, (C 1 -C 8 ) -alkyldisulfanediyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkoxycarbonyl- (C 1 -C 8 ) -alkyl, hyroxycarbonyl- (C 1 -C 8 ) - alkyl, aminocarbonyl (Ci-C8) alkyl, (Ci-Cs) - alkoxycarbonyl (C 3 -C 8) -cycloalkyl, hydroxycarbonyl (C 3 -C 8) cycloalkyl, aminocarbonyl (C 3 -C 8 ) -cycloalkyl, (C 1 -C 8 ) -alkylaminocarbonyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -dialkylaminocarbonyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylaminocarbonyl- (C 3 -C 8) cycloalkyl, (Ci-C 8) dialkylaminocarbonyl (C 3 -C 8) cycloalkyl, (Ci-C8) alkylsulfonyl, (Ci-C 8) haloalkylsulfonyl, (C 3 -C 8 ) - Cycloalkylsulfonyl, (C 3 -C 9) -halocycloalkylsulfonyl, aminosulfonyl, (C 1 -C 8 ) -alkylaminosulfonyl, (C 1 -C 8 ) -dialkylaminosulfonyl, heterocyclyl, (C 3 -C 8 ) -cycloalkyl- (C 3 -C 9) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl) C 8 ) cycloalkyl- (C 3 -C 8 ) -cycloalkyl- (C 3 -C 8 ) -cycloalkyl- (C 3 -C 8 ) -cycloalkylalkyl, aminosulphonyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylaminosulphonylamino, (Ci -C 8 ) - dialkylaminosulfonylamino, (C 1 -C 8 ) -alkoxycarbonylamino, (C 1 -C 8 ) -alkoxycarbonyloxy, (C 1 -C 8 ) -alkoxycarbonylamino- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkenyl, (C 2 -C 8 ) C8) -alkynyl,

R für Wasserstoff, (Ci-C8)-Alkyl, (Ci-C8)-Haloalkyl, (C2-C8)-Alkenyl, (C3-C8)-Alkynyl, (Ci-C8)- Alkoxy-(Ci-C8)-alkyl, (Ci-C8)-Haloalkoxy-(Ci-C8)-alkyl, (Ci-C8)-Alkylthio-(Ci-C8)-alkyl, (Ci-C8)-Haloalkylthio-(Ci-C8)-alkyl, (C3-C8)-Cycloalkyl, Hydroxy-(Ci-C8)-alkylcarbonyl, Amino-(Ci-C8)-alkyl, (Ci-C8)-Alkoxycarbonyl-(Ci-C8)-alkyl, (Ci-C8)-Cyanoalkyl, (Ci-C8)- Alkylthio-(Ci-C8)-alkyl steht, oder R und R mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: R is hydrogen, (Ci-C 8) -alkyl, (Ci-C8) -haloalkyl, (C 2 -C 8) alkenyl, (C3-C8) alkynyl, (Ci-C8) - alkoxy (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -haloalkoxy- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkylthio (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -haloalkylthio - (Ci-C 8) alkyl, (C 3 -C 8) cycloalkyl, hydroxy (Ci-C 8) alkylcarbonyl, amino (Ci-C8) alkyl, (Ci-C8) alkoxycarbonyl ( Ci-C 8) alkyl, (Ci-C 8) cyanoalkyl, (Ci-C 8) - alkylthio (Ci-C8) alkyl, or R and R with the N-atom to which they are attached are a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring, is, except for the compound mentioned below:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]).  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).

Besonders bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin Q für die Gruppen Q-l . l bis Q-7.1 A particularly preferred subject of the invention are compounds of the general formula (I) in which Q represents the groups Q-1. l to Q-7.1

Figure imgf000008_0001
Figure imgf000008_0001

Q-l . l Q-1.2 Q-1.3 Q-2.1 Q-2.2 Q-l. l Q-1.2 Q-1.3 Q-2.1 Q-2.2

Figure imgf000008_0002
Figure imgf000008_0002

Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1

Figure imgf000009_0001
Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1
Figure imgf000009_0001

Q-4.2 Q-5.1 Q-6.1 Q-7.1 steht, für die Gruppe

Figure imgf000009_0002
steht, für Wasserstoff, Fluor, Chlor, Brom, Iod, Cyano, (Ci-C4)-Alkyl, (Ci-C4)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)-Alkylthio, (Ci-C4)-Haloalkylthio, (Ci-C4)-Alkylsulfmyl, (Ci-C4)-Haloalkylsulfmyl, (Ci-C4)-Alkylsulfonyl, (Ci-C4)-Haloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-C6)-Alkyl und (Ci-C6)-Haloalkyl steht, für (Ci-C6)-Alkyl und (Ci-C6)-Haloalkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7- gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C2-C6)-Alkenyl, (C3-C6)-Alkynyl, (Ci-C6)-Cyanoalkyl, (Ci-C6)-Hydroxyalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Cyanocycloalkyl, (C3-C6)-Cycloalkenyl, (Ci-C6)-Alkyl-(C3-C6)-cycloalkyl, (Ci-C6)- Alkoxy-(C3-C6)-cycloalkyl, (Ci-C6)-Haloalkoxy-(C3-C6)-cycloalkyl, (Ci-C6)-Alkylthio-(C3-C6)- cycloalkyl, Aryl-(C3-C6)-cycloalkyl, Heteroaryl-(C3-C6)-cycloalkyl, (Ci-C6)-Alkoxycarbonyl- (C3-C6)-cycloalkyl, Hydroxcarbonyl-(C3-C6)-cycloalkyl, (C3-C6)-Cycloalkyl-(C3-C6)- cycloalkyl, (C3-C6)-cycloalkyl-(Ci-C6)-alkyl, (Ci-C6)-Alkyloxy, (Ci-C6)-Alkylammo, (Ci-C6)- Haloalkyloxy, (Ci-C6)-Haloalkylamino, (Ci-C6)-Cycloalkyloxy, (Ci-C6)-Cycloalkylamino, (Ci-C6)-Alkylthio-(Ci-C6)-alkyl, (Ci-C6)-Alkylsulfmyl-(Ci-C6)-alkyl, (Ci-C6)-Alkylsulfonyl- (Ci-C6)-alkyl, (Ci-C6)-Alkoxy-(Ci-C6)-alkyl, (Ci-C6)-Haloalkoxy-(Ci-C6)-alkyl, Hydroxy- (Ci-C6)-alkyl, Hydrothio-(Ci-C6)-alkyl, Heterocyclyl-(Ci-C6)-alkyl, Aryl-(Ci-C6)-alkyl, Heteroaryl-(Ci-C6)-alkyl, (Ci-C6)-Alkyldisulfanediyl-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl- (Ci-C6)-alkyl, Hydroxycarbonyl-(Ci-C6)-alkyl, Aminocarbonyl-(Ci-C6)-alkyl, (Ci-Ce)- Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxycarbonyl-(C3-C6)-cycloalkyl, Aminocarbonyl- (C3-C6)-cycloalkyl, (Ci-C6)-Alkylaminocarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Dialkylaminocarbonyl (Ci-C6)-alkyl, (Ci-C6)-Alkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C6)-Dialkylaminocarbonyl (C3-C6)-cycloalkyl, (Ci-C6)-Alkylsulfonyl, (Ci-C6)-Haloalkylsulfonyl, (C3-C6)- Cycloalkylsulfonyl, Aminosulfonyl, (Ci-C6)-Alkylaminosulfonyl, (Ci-Ce)- Dialkylaminosulfonyl, Heterocyclyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl, (C3-C6)- Cycloalkyl-(C3-C6)-cycloalkyl-(C3-C6)-Cycloalkyl-(C3-C6)-cycloalkylalkyl, Aminosulfonyl-(C Ce)-alkyl, (Ci-C6)-Alkylaminosulfonylamino, (Ci-C6)-Dialkylaminosulfonylamino, (Ci-Ce)- AlkoxyCarbonylamino, (Ci-C6)-Alkoxycarbonyloxy, (Ci-C6)-Alkoxycarbonylamino-(Ci-C6)- alkyl, (Ci-C6)-Alkenyl, (C2-C6)-Alkynyl, steht, Q-4.2 Q-5.1 Q-6.1 Q-7.1 stands for the group
Figure imgf000009_0002
represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -Halocycloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -haloalkylthio, (C 1 -C 4 ) -alkylsulfmyl, (Ci -C 4) -Haloalkylsulfmyl, (Ci-C 4) alkylsulfonyl, (Ci-C4) haloalkylsulfonyl, represents oxygen or sulfur, is (Ci-C 6) -alkyl and (Ci-C 6) -haloalkyl represents (C 1 -C 6 ) -alkyl and (C 1 -C 6 ) -haloalkyl, or in which R 1 and R 2 together with the C-atom to which they are respectively bonded are completely saturated or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S interrupted and optionally further substituted, total 3-7-membered ring, is, for hydroxy, amino, (Ci-C 6 ) alkyl, (Ci-C 6 ) -haloalkyl, (C 2 -C 6) -alkenyl, (C 3 -C 6) alkynyl, (Ci-C 6) cyanoalkyl, (Ci-C 6) hydroxyalkyl, (C 3 -C 6) - Cycloalkyl, (C 3 -C 6 ) -halocycloalkyl, ( C 3 -C 6) -Cyanocycloalkyl, (C 3 -C 6) cycloalkenyl, (Ci-C 6) -alkyl- (C 3 -C 6) cycloalkyl, (Ci-C6) - alkoxy (C 3 -C 6) cycloalkyl, (Ci-C 6) haloalkoxy (C 3 -C 6) cycloalkyl, (Ci-C 6) alkylthio (C 3 -C 6) - cycloalkyl, aryl (C 3 -C6) -cycloalkyl, heteroaryl- (C 3 -C 6) -cycloalkyl, (C 1 -C 6) -alkoxycarbonyl- (C 3 -C 6) -cycloalkyl, hydroxcarbonyl- (C 3 -C 6) -cycloalkyl, (C 3 -C 6 ) cycloalkyl (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -cycloalkyl- (Ci-C 6) alkyl, (Ci-C 6) alkyloxy, (Ci-C 6) -Alkylammo, (Ci-C 6 ) - Haloalkyloxy, (C 1 -C 6 ) -haloalkylamino, (C 1 -C 6 ) -cycloalkyloxy, (C 1 -C 6 ) -cycloalkylamino, (C 1 -C 6 ) -alkylthio (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) - Alkylsulfmyl (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkylsulfonyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 4 ) -alkyl C 6 ) -haloalkoxy- (C 1 -C 6 ) -alkyl, hydroxy- (C 1 -C 6 ) -alkyl, hydrothio (C 1 -C 6 ) -alkyl, heterocyclyl- (C 1 -C 6 ) -alkyl, aryl- (C 1 -C 6 ) -alkyl, heteroaryl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkyldisulfanediyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxycarbonyl- (C 1 -C 6 ) -alkyl , Hydroxycarbonyl- (C 1 -C 6) -alkyl, aminocarbonyl- (C 1 -C 6) -alkyl, (C 1 -C 6) -alkoxycarbonyl- (C 3 -C 6) -cycloalkyl, hydroxycarbonyl- (C 3 -C 6) -cycloalkyl, aminocarbonyl- C 3 -C 6) -cycloalkyl, (C 1 -C 6) -alkylaminocarbonyl- (C 1 -C 6) -alkyl, (C 1 -C 6) -dialkylaminocarbonyl (C 1 -C 6) -alkyl, (C 1 -C 6) -alkylaminocarbonyl- (C 3 -C 6) ) cycloalkyl, (Ci-C6) -dialkylaminocarbonyl (C 3 -C 6) cycloalkyl, (Ci-C 6) alkylsulfonyl, (Ci-C 6) haloalkylsulfonyl, (C 3 -C 6) - cycloalkylsulfonyl, aminosulphonyl , (C 1 -C 6) -alkylaminosulfonyl, (C 1 -C 6) -dialkylaminos ulfonyl, heterocyclyl, (C 3 -C 6) cycloalkyl- (C 3 -C 6) cycloalkyl, (C 3 -C 6) cycloalkyl- (C 3 -C 6) cycloalkyl- (C 3 -C 6) cycloalkyl- (C 3 -C 6) - cycloalkylalkyl, aminosulfonyl- (C 6 -C 6) alkyl, (C 1 -C 6) alkylaminosulfonylamino, (C 1 -C 6) -dialkylaminosulfonylamino, (C 1 -C 6) -alkoxycarbonylamino, (C 1 -C 6) -alkoxycarbonyloxy, (C 1 -C 6) -alkoxycarbonylamino - (Ci-C6) - alkyl, (Ci-C 6) alkenyl, (C 2 -C 6) alkynyl, stands,

R4 für Wasserstoff, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C2-C6)-Alkenyl, (C3-C6)-Alkynyl, (Ci-C6)- Alkoxy-(Ci-C6)-alkyl, (Ci-C6)-Haloalkoxy-(Ci-C6)-alkyl, (Ci-C6)-Alkylthio-(Ci-C6)-alkyl, (Ci-C6)-Haloalkylthio-(Ci-C6)-alkyl, (C3-C6)-Cycloalkyl, Hydroxy-(Ci-C6)-alkylcarbonyl, Amino-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Cyanoalkyl, (Ci-C6)- Alkylthio-(Ci-C6)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: R 4 represents hydrogen, (Ci-C 6) -alkyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) -alkenyl, (C 3 -C 6) alkynyl, (Ci-C 6) - Alkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkylthio (C 1 -C 6 ) -alkyl, C 6) -Haloalkylthio- (Ci-C 6) alkyl, (C 3 -C 6) cycloalkyl, hydroxy (Ci-C 6) alkylcarbonyl, amino (Ci-C 6) alkyl, (Ci- C 6) alkoxycarbonyl (Ci-C 6) alkyl, (Ci-C 6) cyanoalkyl, (Ci-C 6) - alkylthio, (Ci-C 6) -alkyl, or R 3 and R 4 with the N-atom to which they are attached form a fully saturated or partially saturated, optionally heteroatom-interrupted and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring, with the exception of the following:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]).  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).

Ganz besonders bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin worin Q für die Gruppen Q-l . l bis Q-7.1

Figure imgf000011_0001
A very particularly preferred subject matter of the invention are compounds of the general formula (I) in which Q denotes the groups Q1. l to Q-7.1
Figure imgf000011_0001

Q-l . l Q-1.2 Q-1.3 Q-2.1 Q-2.2 Q-l. l Q-1.2 Q-1.3 Q-2.1 Q-2.2

Figure imgf000011_0002
Figure imgf000011_0002

Q-2.3 -2.4 -3.1 Q-3.2 Q-4.1  Q-2.3 -2.4 -3.1 Q-3.2 Q-4.1

Figure imgf000011_0003
Figure imgf000011_0003

Q-4.2 Q-5.1 Q-6.1 Q-7.1 steht, Q-4.2 Q-5.1 Q-6.1 Q-7.1 stands,

Z für die Gruppe

Figure imgf000011_0004
steht, für Wasserstoff, Fluor, Chlor, Brom, lod, Cyano, (Ci-C3)-Alkyl, (Ci-C3)-Haloalkyl, (C3-C6)- Cycloalkyl, (C3-C6)-Halocycloalkyl, (Ci-C3)-Alkoxy, (Ci-C3)-Haloalkoxy, (Ci-C3)-Alkylthio, (Ci-C3)-Haloalkylthio, (Ci-C3)-Alkylsulfmyl, (Ci-C3)-Haloalkylsulfmyl, (Ci-C3)-Alkylsulfonyl, (Ci-C3)-Haloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, Z for the group
Figure imgf000011_0004
represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 3) alkyl, (Ci-C 3) -haloalkyl, (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -Halocycloalkyl, (C 1 -C 3 ) -alkoxy, (C 1 -C 3 ) -haloalkoxy, (C 1 -C 3 ) -alkylthio, (C 1 -C 3 ) -haloalkylthio, (C 1 -C 3 ) -alkylsulfmyl, (Ci -C 3) -Haloalkylsulfmyl, (Ci-C 3) alkylsulfonyl, (Ci-C 3) haloalkylsulfonyl, represents oxygen or sulfur,

R1 für (Ci-C4)-Alkyl und (Ci-C4)-Haloalkyl steht, R 1 is (C 1 -C 4 ) -alkyl and (C 1 -C 4 ) -haloalkyl,

R für (Ci-C4)-Alkyl und (Ci-C4)-Haloalkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7- gliedrigen Ring bilden, steht, R is (C 1 -C 4 ) -alkyl and (C 1 -C 4 ) -haloalkyl, or wherein R 1 and R 2 together with the C-atom to which they are each bonded, a completely saturated or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, in total 3 Form -7- membered ring stands,

R3 für Hydroxy, Amino, (Ci-C4)-Alkyl, (Ci-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C3-C4)-Alkynyl, (Ci-C4)-Cyanoalkyl, (Ci-C4)-Hydroxyalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Cyanocycloalkyl, (C3-C6)-Cycloalkenyl, (Ci-C4)-Alkyl-(C3-C6)-cycloalkyl, (Ci-C4)- Alkoxy-(C3-C6)-cycloalkyl, (Ci-C4)-Haloalkoxy-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylthio-(C3-C6)- cycloalkyl, Aryl-(C3-C6)-cycloalkyl, Heteroaryl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkoxycarbonyl- (C3-C6)-cycloalkyl, Hydroxcarbonyl-(C3-C6)-cycloalkyl, (C3-C6)-Cycloalkyl-(C3-C6)- cycloalkyl, (C3-C6)-cycloalkyl-(Ci-C4)-alkyl, (Ci-C4)-Alkyloxy, (Ci-C4)-Alkylamino, (Ci-C4)- Haloalkyloxy, (Ci-C4)-Haloalkylamino, (Ci-C4)-Alkylthio-(Ci-C4)-alkyl, (Ci-C4)-Alkylsulfinyl- (Ci-C4)-alkyl, (Ci-C4)-Alkylsulfonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkoxy-(Ci-C4)-alkyl, (Ci-C4)- Haloalkoxy-(Ci-C4)-alkyl, Hydroxy-(Ci-C4)-alkyl, Hydrothio-(Ci-C4)-alkyl, Heterocyclyl- (Ci-C4)-alkyl, Aryl-(Ci-C4)-alkyl, Heteroaryl-(Ci-C4)-alkyl, (Ci-C4)-Alkyldisulfanediyl-(Ci-C4)- alkyl, (Ci-C4)-Alkoxycarbonyl-(Ci-C4)-alkyl, Hydroxycarbonyl-(Ci-C4)-alkyl, Aminocarbonyl- (Ci-C4)-alkyl, (Ci-C4)-Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxycarbonyl-(C3-Ce)- cycloalkyl, Aminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylaminocarbonyl-(Ci-C4)-alkyl, (Ci-C4)-Dialkylaminocarbonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Dialkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylsulfonyl, (Ci-C4)- Haloalkylsulfonyl, (C3-C6)-Cycloalkylsulfonyl, Aminosulfonyl, (Ci-C4)-Alkylaminosulfonyl, (Ci-C4)-Dialkylaminosulfonyl, Heterocyclyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl, (C3-Ce)- Cycloalkyl-(C3-C6)-cycloalkyl-(C3-C6)-Cycloalkyl-(C3-C6)-cycloalkylalkyl, Aminosulfonyl-(Ci- C4)-alkyl, (Ci-C4)-Alkylaminosulfonylamino, (Ci-C4)-Dialkylaminosulfonylamino, (Ci-C4)- Alkoxycarbonylamino, (Ci-C4)-Alkoxycarbonyloxy, (Ci-C4)-Alkoxycarbonylamino-(Ci-C4)- alkyl, (Ci-C4)-Alkenyl, (C2-C4)-Alkynyl steht, R 3 is hydroxy, amino, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 2 -C 4) alkenyl, (C 3 -C 4) alkynyl, (Ci-C 4 ) -Cyanoalkyl, (C 1 -C 4 ) -hydroxyalkyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -halocycloalkyl, (C 3 -C 6 ) -cyanocycloalkyl, (C 3 -C 6 ) cycloalkenyl, (Ci-C 4) -alkyl- (C 3 -C 6) cycloalkyl, (Ci-C4) - alkoxy- (C 3 -C 6) cycloalkyl, (Ci-C 4) haloalkoxy (C 3 -C 6) cycloalkyl, (Ci-C 4) alkylthio (C 3 -C 6) - cycloalkyl, aryl (C 3 -C 6) cycloalkyl, heteroaryl (C 3 -C 6) cycloalkyl , (C 1 -C 4 ) alkoxycarbonyl (C 3 -C 6) cycloalkyl, hydroxcarbonyl (C 3 -C 6) cycloalkyl, (C 3 -C 6) cycloalkyl (C 3 -C 6) cycloalkyl, (C 3 -C 6) -cycloalkyl- (Ci-C 4) alkyl, (Ci-C4) -alkyloxy, (Ci-C 4) alkylamino, (Ci-C 4) - haloalkyloxy, (Ci-C 4) Haloalkylamino, (C 1 -C 4 ) -alkylthio (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkylsulfinyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkylsulfonyl- (C 1 -C 4 ) -alkyl) -C 4) alkyl, (Ci-C 4) alkoxy (Ci-C 4) alkyl, (Ci-C4) - haloalkoxy (Ci-C 4) alkyl, hydroxy (Ci-C 4 ) -alkyl, hydrothio (C 1 -C 4 ) -alkyl, Het erocyclyl- (Ci-C 4) alkyl, aryl (Ci-C 4) alkyl, heteroaryl (Ci-C 4) alkyl, (Ci-C 4) -Alkyldisulfanediyl- (Ci-C4) - alkyl , (C 1 -C 4 ) -alkoxycarbonyl- (C 1 -C 4 ) -alkyl, hydroxycarbonyl- (C 1 -C 4 ) -alkyl, aminocarbonyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkoxycarbonyl- (C 3 -C 6) -cycloalkyl, hydroxycarbonyl- (C 3 -C 6) -cycloalkyl, aminocarbonyl- (C 3 -C 6) -cycloalkyl, (C 1 -C 4 ) -alkylaminocarbonyl- (C 1 -C 4 ) -alkyl, ( Ci-C 4) dialkylaminocarbonyl (Ci-C 4) alkyl, (Ci-C4) -alkylaminocarbonyl- (C 3 -C 6) cycloalkyl, (Ci-C4) dialkylaminocarbonyl (C3-C6) cycloalkyl, (Ci-C 4) alkylsulfonyl, (Ci-C4) - haloalkylsulfonyl, (C 3 -C 6) cycloalkylsulfonyl, aminosulfonyl, (Ci-C4) alkylaminosulfonyl, (Ci-C 4) dialkylaminosulfonyl, Heterocyclyl, (C 3 -C 6) -cycloalkyl- (C 3 -C 6) -cycloalkyl, (C 3 -Ce) -cycloalkyl- (C 3 -C 6) -cycloalkyl- (C 3 -C 6) -cycloalkyl- (C 3 C6) cycloalkylalkyl, aminosulphonyl (Ci- C4) alkyl, (Ci-C 4) -Alkylaminosulfonylamino, (Ci-C 4) -Dialkylaminosulfonylamino, (Ci-C 4) - alkoxycarbonylamino, (C i-C4) alkoxycarbonyloxy, (Ci-C 4) alkoxycarbonylamino (Ci-C4) - alkyl, (Ci-C 4) -alkenyl, (C 2 -C 4) alkynyl group,

R4 für Wasserstoff, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, Hydroxycarbonyl-(Ci-C6)-alkyl, Amino- (Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl-(Ci-C6)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: R 4 is hydrogen, (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, hydroxycarbonyl- (C 1 -C 6 ) -alkyl, amino- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxycarbonyl - (Ci-C 6 ) -alkyl, or R 3 and R 4 with the N-atom to which they are attached, a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is formed, except the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]). Im Speziellen bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin 2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]). In particular preferred subject of the invention are compounds of general formula (I) wherein

Figure imgf000013_0001
Figure imgf000013_0001

steht,  stands,

Z für die Gruppe

Figure imgf000013_0002
steht, Z for the group
Figure imgf000013_0002
stands,

Y für Wasserstoff, Fluor, Chlor, Brom, lod, Cyano, (Ci-C2)-Alkyl, (Ci-C2)-Haloalkyl, (C3-C4)- Cycloalkyl, (Ci-C2)-Alkoxy, (Ci-C2)-Haloalkoxy, (Ci-C2)-Alkylthio, (Ci-C2)-Haloalkylthio, (Ci-C2)-Alkylsulfmyl, (Ci-C2)-Haloalkylsulfmyl, (Ci-C2)-Alkylsulfonyl, (C1-C2)- Haloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-C2)-Alkyl steht, für (Ci-C2)-Alkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-4- gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-C4)-Alkyl, (Ci-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C3-C4)-Alkynyl, (Ci-C4)-Cyanoalkyl, (Ci-C4)-Hydroxyalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Cyanocycloalkyl, (C3-C6)-Cycloalkenyl, (Ci-C4)-Alkyl-(C3-C6)-cycloalkyl, (Ci-C4)- Alkoxy-(C3-C6)-cycloalkyl, (Ci-C4)-Haloalkoxy-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylthio-(C3-C6)- cycloalkyl, Aryl-(C3-C6)-cycloalkyl, Heteroaryl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkoxycarbonyl- (C3-C6)-cycloalkyl, Hydroxcarbonyl-(C3-C6)-cycloalkyl, (C3-C6)-Cycloalkyl-(C3-C6)- cycloalkyl, (C3-C6)-cycloalkyl-(Ci-C4)-alkyl, (Ci-C4)-Alkyloxy, (Ci-C4)-Alkylamino, (Ci-C4)- Haloalkyloxy, (Ci-C4)-Haloalkylamino, (Ci-C4)-Alkylthio-(Ci-C4)-alkyl, (Ci-C4)-Alkylsulfinyl- (Ci-C4)-alkyl, (Ci-C4)-Alkylsulfonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkoxy-(Ci-C4)-alkyl, (Ci-C4)- Haloalkoxy-(Ci-C4)-alkyl, Hydroxy-(Ci-C4)-alkyl, Hydrothio-(Ci-C4)-alkyl, Heterocyclyl- (Ci-C4)-alkyl, Aryl-(Ci-C4)-alkyl, Heteroaryl-(Ci-C4)-alkyl, (Ci-C4)-Alkyldisulfanediyl-(Ci-C4)- alkyl, (Ci-C4)-Alkoxycarbonyl-(Ci-C4)-alkyl, Hydroxycarbonyl-(Ci-C4)-alkyl, Aminocarbonyl- (Ci-C4)-alkyl, (Ci-C4)-Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxycarbonyl-(C3-Ce)- cycloalkyl, Aminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylaminocarbonyl-(Ci-C4)-alkyl, (Ci-C4)-Dialkylaminocarbonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Dialkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylsulfonyl, (Ci-C4)- Haloalkylsulfonyl, (C3-C6)-Cycloalkylsulfonyl, Aminosulfonyl, (Ci-C4)-Alkylaminosulfonyl, (Ci-C4)-Dialkylaminosulfonyl, Heterocyclyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl, (C3-Ce)- Cycloalkyl-(C3-C6)-cycloalkyl-(C3-C6)-Cycloalkyl-(C3-C6)-cycloalkylalkyl, Aminosulfonyl-(Ci- C4)-alkyl, (Ci-C4)-Alkylaminosulfonylamino, (Ci-C4)-Dialkylaminosulfonylamino, (Ci-C4)- Alkoxycarbonylamino, (Ci-C4)-Alkoxycarbonyloxy, (Ci-C4)-Alkoxycarbonylamino-(Ci-C4)- alkyl, (Ci-C4)-Alkenyl, (C2-C4)-Alkynyl steht, für Wasserstoff, (Ci-C6)-Alkyl, Hydroxycarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl- (Ci-C6)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: Y represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 2) alkyl, (Ci-C 2) -haloalkyl, (C 3 -C 4) - cycloalkyl, (Ci-C 2) alkoxy , (C 1 -C 2 ) -haloalkoxy, (C 1 -C 2 ) -alkylthio, (C 1 -C 2 ) -haloalkylthio, (C 1 -C 2 ) -alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 4) -alkyl 2 ) -alkylsulfonyl, (C 1 -C 2 ) -haloalkylsulfonyl, represents oxygen or sulfur, represents (C 1 -C 2 ) -alkyl, is (C 1 -C 2 ) -alkyl, or where R 1 and R 2 together with the C-atom to which they are each bonded are a completely saturated or partially saturated, where appropriate by one to three heteroatoms from the group N, O and S interrupted and optionally further substituted, together form 3-4 membered ring, represents hydroxy, amino, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 2 -C 4) alkenyl, (C 3 -C 4) alkynyl, (Ci-C 4) cyanoalkyl, (Ci-C 4) hydroxyalkyl, (C 3 -C 6) -cycloalkyl, (C 3 -C 6) halocycloalkyl , (C 3 -C 6) -Cyanocycloalkyl, (C 3 -C 6) cycloalkenyl, (Ci-C 4) -alkyl- (C 3 -C 6) cycloalkyl, (Ci-C4) - alkoxy- ( C 3 -C 6) cycloalkyl, (Ci-C 4) haloalkoxy (C 3 -C 6) cycloalkyl, (Ci-C 4) alkylthio (C 3 -C 6) - cycloalkyl, aryl ( C 3 -C 6) -cycloalkyl, heteroaryl- (C 3 -C 6) -cycloalkyl, (C 1 -C 4 ) -alkoxycarbonyl- (C 3 -C 6) -cycloalkyl, hydroxcarbonyl- (C 3 -C 6) -cycloalkyl, (C 3-C6) cycloalkyl (C 3 -C 6) - cycloalkyl, (C 3 -C 6) -cycloalkyl- (Ci-C 4) alkyl, (Ci- C 4) -alkyloxy, (Ci-C 4) alkylamino, (Ci-C 4) - haloalkyloxy, (Ci-C 4) -Haloalkylamino, (Ci-C 4) alkylthio (Ci-C 4) -alkyl , (C 1 -C 4 ) -alkylsulfinyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkylsulfonyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkoxy- (C 1 -C 4 ) -alkyl) 4 ) -alkyl, (C 1 -C 4 ) -haloalkoxy- (C 1 -C 4 ) -alkyl, hydroxy- (C 1 -C 4 ) -alkyl, hydrothio (C 1 -C 4 ) -alkyl, heterocyclyl- (C 1 -C 4 ) -alkyl, C 4) alkyl, aryl (Ci-C 4) alkyl, heteroaryl (Ci-C 4) alkyl, (Ci-C 4) -Alkyldisulfanediyl- (Ci-C4) - alkyl, (Ci-C 4) alkoxycarbonyl (Ci-C 4) alkyl, hydroxycarbonyl- (Ci-C 4) alkyl, aminocarbonyl (Ci-C 4) alkyl, (Ci-C 4) alkoxycarbonyl (C 3 -C 6 ) -cycloalkyl, hydroxycarbonyl- (C 3 -C 6) -cycloalkyl, aminocarbonyl- (C 3 -C 6) -cycloalkyl, (C 1 -C 4 ) -alkylaminocarbonyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) dialkylaminocarbonyl (Ci-C 4) alkyl, (Ci-C4) -alkylaminocarbonyl- (C 3 -C 6) cycloalkyl, (Ci-C4) dialkylaminocarbonyl (C3-C6) cycloalkyl, (C -C 4 ) alkylsulfonyl, (Ci-C 4 ) - Haloalkylsulfonyl, (C 3 -C 6) -Cycloalkylsulfonyl, aminosulfonyl, (Ci-C 4 ) -A alkylaminosulfonyl, (C 1 -C 4 ) -dialkylaminosulfonyl, heterocyclyl, (C 3 -C 6) -cycloalkyl- (C 3 -C 6) -cycloalkyl, (C 3 -Ce) -cycloalkyl- (C 3 -C 6) -cycloalkyl- ( C 3 -C 6) -cycloalkyl- (C 3 -C 6) -cycloalkylalkyl, aminosulphonyl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkylaminosulphonylamino, (C 1 -C 4 ) -dialkylaminosulphonylamino, (C 1 -C 4 ) -cycloalkylalkyl; 4) - alkoxycarbonylamino, (Ci-C4) alkoxycarbonyloxy, (Ci-C 4) alkoxycarbonylamino (Ci-C4) - alkyl, (Ci-C 4) -alkenyl, (C 2 -C 4) alkynyl is hydrogen, (C 1 -C 6 ) -alkyl, hydroxycarbonyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxycarbonyl- (C 1 -C 6 ) -alkyl, or R 3 and R 4 with the N Atom to which they are attached form a completely saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is, except for the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]). Im ganz Speziellen bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]). In a very particularly preferred subject of the invention are compounds of general formula (I) wherein

Q für die Gruppen Q-l . l bis Q-7.1 Q for the groups Q-l. l to Q-7.1

Figure imgf000015_0001
Figure imgf000015_0001

steht,  stands,

Z für die Gruppen Z- 1.1 bis Z-5.1 Z for the groups Z-1.1 to Z-5.1

Figure imgf000015_0002
Figure imgf000016_0001
Figure imgf000017_0001
Figure imgf000018_0001
Figure imgf000015_0002
Figure imgf000016_0001
Figure imgf000017_0001
Figure imgf000018_0001

Figure imgf000019_0001
Figure imgf000020_0001
Figure imgf000021_0001
Figure imgf000022_0001
Figure imgf000019_0001
Figure imgf000020_0001
Figure imgf000021_0001
Figure imgf000022_0001

Figure imgf000023_0001
Figure imgf000023_0001

Figure imgf000024_0001
Figure imgf000025_0001
Figure imgf000026_0001
Figure imgf000027_0001
Figure imgf000028_0001
Figure imgf000024_0001
Figure imgf000025_0001
Figure imgf000026_0001
Figure imgf000027_0001
Figure imgf000028_0001

Z-1.400 steht,  Z-1,400 stands,

Y für Wasserstoff, Fluor, Chlor, Brom, Iod, Cyano, (Ci-C2)-Alkyl, (Ci-C2)-Haloalkyl, (C3-C4)- Cycloalkyl, (Ci-C2)-Alkoxy, (Ci-C2)-Haloalkoxy, (Ci-C2)-Alkylthio, (Ci-C2)-Haloalkylthio, (Ci-C2)-Alkylsulfmyl, (Ci-C2)-Haloalkylsulfmyl, (Ci-C2)-Alkylsulfonyl, (C1-C2)- Haloalkylsulfonyl steht, Y represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (C 1 -C 2 ) -alkyl, (C 1 -C 2 ) -haloalkyl, (C 3 -C 4) -cycloalkyl, (C 1 -C 2 ) -alkoxy, ( C 1 -C 2 ) -haloalkoxy, (C 1 -C 2 ) -alkylthio, (C 1 -C 2 ) -haloalkylthio, (C 1 -C 2 ) -alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 2 ) Alkylsulfonyl, (C 1 -C 2) - haloalkylsulfonyl,

W für Sauerstoff oder Schwefel steht; W is oxygen or sulfur;

R1 für CH3 steht, R 1 is CH 3 ,

R2 für CH3 steht, ausgenommen der nachfolgend genannten Verbindung: R 2 is CH 3 , with the exception of the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]).  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).

Im äußerst besonders Speziellen bevorzugter Erfindungsgegenstand sind Verbindungen der allgemeinen Formel (I), worin In a particularly particularly preferred subject of the invention are compounds of general formula (I) wherein

Q für eine der in der oben stehenden Tabelle spezifisch genannten Gruppierungen Q-1.1 bis Q-7.1 steht. Z für die Gruppen Z- 1.1 bis Z- 1.400 steht. Q stands for one of the groupings Q-1.1 to Q-7.1 mentioned specifically in the table above. Z stands for the groups Z-1.1 to Z-1,400.

Y für Wasserstoff, Fluor, Chlor, Brom, Iod, Cyano, CH3, (Ci)-Haloalkyl, (C3-C3)-Cycloalkyl, (Ci-C2)-Alkoxy, (Ci)-Haloalkoxy, (Ci-C2)-Alkylthio, (Ci-C2)-Alkylsulfinyl, (C1-C2)- Alkylsulfonyl steht, Y is hydrogen, fluorine, chlorine, bromine, iodine, cyano, CH 3 , (Ci) -haloalkyl, (C 3 -C 3 ) -cycloalkyl, (Ci-C 2 ) -alkoxy, (Ci) -haloalkoxy, (Ci C 2 ) alkylthio, (C 1 -C 2 ) -alkylsulfinyl, (C 1 -C 2 ) -alkylsulfonyl,

W für Sauerstoff oder Schwefel steht; R1 für CH3 steht, W is oxygen or sulfur; R 1 is CH 3 ,

R für CH3 steht, ausgenommen der nachfolgend genannten Verbindung: R is CH 3 , with the exception of the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-N,N,2-trimethylpropanamid (= CAS [63687-70-7]).  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).

Die oben aufgeführten allgemeinen oder in Vorzugsbereichen aufgeführten Restedefinitionen gelten sowohl für die Endprodukte der allgemeinen Formel (I) als auch entsprechend für die jeweils zur Herstellung benötigten Ausgangs- oder Zwischenprodukte. Diese Restedefinitionen können The general or preferred radical definitions given above apply both to the end products of the general formula (I) and correspondingly to the starting materials or intermediates required in each case for the preparation. These remainder definitions can

untereinander, also auch zwischen den angegebenen bevorzugten Bereichen beliebig kombiniert werden. among each other, so also between the specified preferred ranges are arbitrarily combined.

Vor allem aus den Gründen der höheren herbiziden Wirkung, besseren Selektivität und/oder besseren Herstellbarkeit sind erfindungsgemäße Verbindungen der genannten allgemeinen Formel (I) oder deren Salze bzw. deren erfindungsgemäße Verwendung von besonderem Interesse, worin einzelne Reste eine der bereits genannten oder im folgenden genannten bevorzugten Bedeutungen haben, oder insbesondere solche, worin eine oder mehrere der bereits genannten oder im Folgenden genannten bevorzugten Bedeutungen kombiniert auftreten. Im Hinblick auf die erfindungsgemäßen Verbindungen werden die vorstehend und weiter unten verwendeten Bezeichnungen erläutert. Diese sind dem Fachmann geläufig und haben insbesondere die im Folgenden erläuterten Bedeutungen: Above all, for reasons of higher herbicidal activity, better selectivity and / or better manufacturability, compounds of the general formula (I) according to the invention or their salts or their use according to the invention are of particular interest, in which individual radicals are one of those already mentioned or mentioned below have preferred meanings, or in particular those in which one or more of the already mentioned or mentioned below preferred meanings occur in combination. With regard to the compounds according to the invention, the terms used above and below are explained. These are familiar to the person skilled in the art and in particular have the meanings explained below:

Sofern nicht anders definiert, gilt generell für die Bezeichnung von chemischen Gruppen, dass die Anbindung an das Gerüst bzw. den Rest des Moleküls über das zuletzt genannte Strukturelement der betreffenden chemischen Gruppe erfolgt, d.h. beispielsweise im Falle von (C2-Cg)-Alkenyloxy über das Sauerstoffatom, und im Falle von Heterocyclyl-(Ci-Cg)-alkyl oder R120(0)C-(Ci-Cg)-Alkyl jeweils über das C-Atom der Alkylgruppe. Erfindungsgemäß steht "Alkylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Alkylsulfonyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Unless otherwise defined, generally applies to the designation of chemical groups that the attachment to the skeleton or the rest of the molecule via the last-mentioned structural element of the chemical group in question, ie, for example, in the case of (C2-Cg) alkenyloxy over the oxygen atom, and in the case of heterocyclyl (Ci-Cg) alkyl or R 12 0 (0) C (Ci-Cg) alkyl in each case via the C atom of the alkyl group. According to the invention "alkylsulfonyl" - alone or as part of a chemical group - is straight-chain or branched alkylsulfonyl, preferably with 1 to 8, or with 1 to 6

Kohlenstoffatomen, z.B. (aber nicht beschränkt auf) (Ci-C6)-Alkylsulfonyl wie Methylsulfonyl, Ethyl- sulfonyl, Propylsulfonyl, 1 -Methylethylsulfonyl, Butylsulfonyl, 1 -Methylpropylsulfonyl, 2-Methyl- propylsulfonyl, 1 ,1 -Dimethylethylsulfonyl, Pentylsulfonyl, 1 -Methylbutylsulfonyl, 2-Methylbutyl- sulfonyl, 3 -Methylbutylsulfonyl, 1 ,1 -Dimethylpropylsulfonyl, 1 ,2-Dimethylpropylsulfonyl, 2,2-Di- methylpropylsulfonyl, 1 -Ethylpropylsulfonyl, Hexylsulfonyl, 1 -Methylpentylsulfonyl, 2-Methyl- pentylsulfonyl, 3 -Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1 , 1 -Dimethylbutylsulfonyl, 1 ,2-Di- methylbutylsulfonyl, 1 ,3 -Dimethylbutylsulfonyl, 2,2-Dimethylbutylsulfonyl, 2,3-Dimethylbutylsulfonyl, 3 ,3 -Dimethylbutylsulfonyl, 1 -Ethylbutylsulfonyl, 2-Ethylbutylsulfonyl, 1 , 1 ,2-Trimethylpropylsulfonyl, 1 ,2,2-Trimethylpropylsulfonyl, 1 -Ethyl- 1 -methylpropylsulfonyl und 1 -Ethyl-2-methylpropylsulfonyl. Erfindungsgemäß steht "Heteroarylsulfonyl" für gegebenenfalls substituiertes Pyridylsulfonyl, Carbon atoms, for example (but not limited to) (C 1 -C 6) alkylsulfonyl, such as methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methyl-propylsulfonyl, 1, 1-dimethylethylsulfonyl, pentylsulfonyl, 1 Methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3 Methylpentylsulfonyl, 4-methylpentylsulfonyl, 1, 1-dimethylbutylsulfonyl, 1, 2-di- methylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl. According to the invention "heteroarylsulfonyl" is optionally substituted pyridylsulfonyl,

Pyrimidinylsulfonyl, Pyrazinylsulfonyl oder gegebenenfalls substituiertes polycyclisches Pyrimidinylsulfonyl, pyrazinylsulfonyl or optionally substituted polycyclic

Heteroarylsulfonyl, hier insbesondere gegebenenfalls substituiertes Chinolinylsulfonyl, beispielsweise substituiert durch Fluor, Chlor, Brom, Iod, Cyano, Nitro, Alkyl-, Haloalkyl-, Haloalkoxy-, Amino-, Alkylamino-, Alkylcarbonylamino-, Dialkylamino- oder Alkoxygruppen. Heteroarylsulfonyl, here in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino or alkoxy groups.

Erfindungsgemäß steht "Alkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 According to the invention "alkylthio" - alone or as part of a chemical group - is straight-chain or branched S-alkyl, preferably with 1 to 8, or with 1 to 6

Kohlenstoffatomen, wie (Ci-Cio)-, (CI-CÖ)- oder (Ci-C4)-Alkylthio, z.B. (aber nicht beschränkt auf) (Ci- Ce)-Alkylthio wie Methylthio, Ethylthio, Propylthio, 1 -Methylethylthio, Butylthio, 1 -Methylpropylthio, 2-Methylpropylthio, 1 ,1 -Dimethylethylthio, Pentylthio, 1 -Methylbutylthio, 2-Methylbutylthio, 3- Methylbutylthio, 1 ,1 -Dimethylpropylthio, 1 ,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1 - Ethylpropylthio, Hexylthio, 1 -Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methyl- pentylthio, 1 ,1 -Dimethylbutylthio, 1 ,2-Dimethylbutylthio, 1 ,3-Dimethylbutylthio, 2,2-Dimethylbutyl- thio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1 -Ethylbutylthio, 2-Ethylbutylthio, 1 , 1 ,2-Tri- methylpropylthio, 1 ,2,2-Trimethylpropylthio, 1 -Ethyl- 1 -methylpropylthio und 1 -Ethyl-2-methyl- propylthio. Carbon atoms, such as (Ci-Cio) -, (CI-CÖ) - or (Ci-C4) -alkylthio, e.g. (but not limited to) (ce-Ce) -alkylthio, such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 1, 1-dimethylpropylthio, 1, 2-dimethylpropylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1, 1 Dimethylbutylthio, 1, 2-dimethylbutylthio, 1, 3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1, 1, 2-tri methylpropylthio, 1, 2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl-2-methylpropylthio.

„Cycloalkylthio" bedeutet bedeutet erfindungsgemäßt ein über ein Schwefelatom gebundenen "Cycloalkylthio" means according to the invention a bonded via a sulfur atom

Cycloalkylrest. Cycloalkyl.

„Alkylsulfinyl (Alkyl-S(=0)-)", soweit nicht an anderer Stelle anders definiert steht erfindungsgemäß für Alkylreste, die über -S(=0)- an das Gerüst gebunden sind, wie (Ci-Cio)-, (CI-CÖ)- oder (C1-C4)- Alkylsulfinyl, z. B. (aber nicht beschränkt auf) (Ci-C6)-Alkylsulfinyl wie Methylsulfinyl, Ethylsulfinyl, Propylsulfinyl, 1 -Methylethylsulfinyl, Butylsulfinyl, 1 -Methylpropylsulfinyl, 2-Methylpropylsulfinyl, 1 , 1 -Dimethylethylsulfmyl, Pentylsulfmyl, 1 -Methylbutylsulfmyl, 2-Methylbutylsulfmyl, 3 - Methylbutylsulfinyl, 1 ,1 -Dimethylpropylsulfinyl, 1 ,2-Dimethylpropylsulfinyl, 2,2-Di- methylpropylsulfinyl, 1 -Ethylpropylsulfinyl, Hexylsulfinyl, 1 -Methylpentylsulfinyl, 2-Methylpentyl- sulfinyl, 3 -Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1 ,1 -Dimethylbutylsulfinyl, 1 ,2-Dimethyl- butylsulfinyl, 1 ,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- Dimethylbutylsulfinyl, 1 -Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1 ,1 ,2-Trimethylpropylsulfinyl, 1 ,2,2- Trimethylpropylsulfinyl, 1 -Ethyl- 1 -methylpropylsulfinyl und 1 -Ethyl-2-methylpropylsulfinyl. „Alkoxy" bedeutet ein über ein Sauerstoffatom gebundenen Alkylrest, z. B. (aber nicht beschränkt auf) (Ci-Ce)-Alkoxy wie Methoxy, Ethoxy, Propoxy, 1 -Methylethoxy, Butoxy, 1 -Methylpropoxy, 2- Methylpropoxy, 1 ,1 -Dimethylethoxy, Pentoxy, 1 -Methylbutoxy, 2-Methylbutoxy, 3-Methylbutoxy, 1 ,1 - Dimethylpropoxy, 1 ,2-Dimethylpropoxy, 2,2-Dimethylpropoxy, 1 -Ethylpropoxy, Hexoxy, 1 - Methylpentoxy, 2-Methylpentoxy, 3-Methylpentoxy, 4-Methylpentoxy, 1 ,1 -Dimethylbutoxy, 1 ,2-Di- methylbutoxy, 1 ,3-Dimethylbutoxy, 2,2-Dimethylbutoxy, 2,3-Dimethylbutoxy, 3,3-Dimethylbutoxy, 1 - Ethylbutoxy, 2-Ethylbutoxy, 1 , 1 ,2-Trimethylpropoxy, 1 ,2,2-Trimethylpropoxy, 1 -Ethyl-l -methylpropoxy und 1 -Ethyl-2-methylpropoxy. Alkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkenylrest, Alkinyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkinylrest wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenoxy bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)-Alkmoxy. "Alkylsulfinyl (alkyl-S (= 0) -)", unless otherwise defined elsewhere, according to the invention for alkyl radicals which are bonded to the skeleton via -S (= O) -, such as (C 1 -C 10) -, ( CI-CÖ) - or (C 1 -C 4) -alkylsulfinyl, for example (but not limited to) (C 1 -C 6) -alkylsulfinyl, such as methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2- Methylpropylsulfinyl, 1, 1-dimethylethylsulfmyl, pentylsulfmyl, 1-methylbutylsulfmyl, 2-methylbutylsulfmyl, 3-methylbutylsulfinyl, 1, 1-dimethylpropylsulfinyl, 1, 2-dimethylpropylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, hexylsulfinyl, 1 - Methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentylsulfinyl, 1, 1-dimethylbutylsulfinyl, 1, 2-dimethylbutylsulfinyl, 1,3-dimethylbutylsulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3, 3-dimethylbutylsulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1, 1, 2-trimethylpropyl sulfinyl, 1, 2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropylsulfinyl and 1-ethyl-2-methylpropylsulfinyl. "Alkoxy" means an alkyl radical bonded through an oxygen atom, for example (but not limited to) (C 1 -C 6) alkoxy, such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1 , 1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1, 1-dimethylpropoxy, 1, 2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy , 3-methylpentoxy, 4-methylpentoxy, 1, 1-dimethylbutoxy, 1, 2-dimethylbutoxy, 1, 3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy , 2-ethylbutoxy, 1, 1, 2-trimethylpropoxy, 1, 2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy. Alkenyloxy means an alkenyl radical bonded through an oxygen atom, alkynyloxy means an above an oxygen atom bonded alkynyl group such as (C 2 -C 1 0) -, (C 2 -C 6) - or (C 2 -C 4) alkenoxy, and (C3-C10) -, (C 3 -C 6) - or (C 3 -C 4 ) -alkoxy.

„Cycloalkyloxy" bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylrest. "Cycloalkyloxy" means a cycloalkyl group bonded via an oxygen atom.

„Alkylcarbonyl" (Alkyl-C(=0)-), soweit nicht an anderer Stelle anders definiert, steht erfindungsgemäß für Alkylreste, die über -C(=0)- an das Gerüst gebunden sind, wie (C1-C10)-, (Ci-Ce)- oder (C1-C4)- Alkylcarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der "Alkylcarbonyl" (alkyl-C (= O) -), unless otherwise defined elsewhere, is according to the invention alkyl radicals which are bonded to the skeleton via -C (= O) -, such as (C 1 -C 10) -, (Ci-Ce) - or (C1-C4) - alkylcarbonyl The number of carbon atoms refers to the alkyl radical in the

Alkylcarbonylgruppe. Alkylcarbonyl.

„Alkoxycarbonyl (Alkyl-0-C(=0)-)", soweit nicht an anderer Stelle anders definiert: Alkylreste, die über -0-C(=0)- an das Gerüst gebunden sind, wie (C1-C10)-, (CI-CÖ)- oder (Ci-C4)-Alkoxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkylrest in der Alkoxycarbonylgruppe. Analog stehen „Alkenyloxycarbonyl" und„Alkinyloxycarbonyl", soweit nicht an anderer Stelle anders definiert, erfindungsgemäß für Alkenyl- bzw. Alkinylreste, die über -0-C(=0)- an das Gerüst gebunden sind, wie (C2-C10)-, (C2-C6)- oder (C2-C4)-Alkenyloxycarbonyl bzw. (C3-C10)-, (C3-C6)- oder (C3-C4)- Alkinyloxycarbonyl. Die Anzahl der C-Atome bezieht sich dabei auf den Alkenyl- bzw. Alkinylrest in der Alken- bzw. Alkinyloxycarbonylgruppe. "Alkoxycarbonyl (alkyl-0-C (= 0) -)", Unless otherwise defined elsewhere: alkyl radicals attached to the skeleton via -0-C (= 0) - such as (C1-C10) - , (CI-CÖ) - or (C 1 -C 4) -alkoxycarbonyl The number of C atoms here refers to the alkyl radical in the alkoxycarbonyl group, analogously "alkenyloxycarbonyl" and "alkynyloxycarbonyl", unless otherwise defined elsewhere, according to the invention for alkenyl or alkynyl radicals which are bonded to the skeleton via -O-C (= O), such as (C 2 -C 10) -, (C 2 -C 6 ) - or (C 2 -C 4 ) - alkenyloxycarbonyl or (C3-C10) -, (C 3 -C 6) - or (C3-C4) - alkynyloxycarbonyl the number of carbon atoms refers to the alkenyl and alkynyl group in the alkynyloxycarbonyl group or alkene. ,

Der Begriff„Alkylcarbonyloxy" (Alkyl-C(=0)-0-) steht erfindungsgemäß, soweit nicht an anderer Stelle anders definiert, für Alkylreste, die über eine Carbonyloxygruppe (-C(=0)-0-) mit dem Sauerstoff an das Gerüst gebunden sind, wie (C1-C10)-, (Ci-Ce)- oder (Ci-C i)-Alkylcarbonyloxy. Die Anzahl der C- Atome bezieht sich dabei auf den Alkylrest in der Alkylcarbonyloxygruppe. The term "alkylcarbonyloxy" (alkyl-C (= 0) -O-) is according to the invention, unless otherwise defined elsewhere, for alkyl radicals which have a carbonyloxy group (-C (= O) -O-) with the oxygen the skeleton are bonded, such as (C 1 -C 10) -, (C 1 -C 6) - or (C 1 -C 4) -alkylcarbonyloxy The number of C atoms here refers to the alkyl radical in the alkylcarbonyloxy group.

Der Begriff„Aryl" bedeutet ein gegebenenfalls substituiertes mono-, bi- oder polycyclisches aromatisches System mit vorzugsweise 6 bis 14, insbesondere 6 bis 10 Ring-C- Atomen, beispielsweise Phenyl, Naphthyl, Anthryl, Phenanthrenyl, und ähnliches, vorzugsweise Phenyl. Vom Begriff„gegebenenfalls substituiertes Aryl" sind auch mehrcyclische Systeme, wie Tetrahydronaphtyl, Indenyl, Indanyl, Fluorenyl, Biphenylyl, umfasst, wobei die Bindungsstelle am aromatischen System ist. Von der Systematik her ist„Aryl" in der Regel auch von dem Begriff „gegebenenfalls substituiertes Phenyl" umfasst. Bevorzugte Aryl-Substituenten sind hier zum Beispiel Wasserstoff, Halogen, Alkyl, Cycloalkyl, Cycloalkylalkyl, Cycloalkenyl, Halocycloalkyl, Alkenyl, Alkinyl, Aryl, Arylalkyl, Heteroaryl, Heteroarylalkyl, Heterocyclyl, Heterocyclylalkyl, Alkoxyalkyl, Alkylthio, Haloalkylthio, Haloalkyl, Alkoxy, Haloalkoxy, Cycloalkoxy, Cycloalkylalkoxy, Aryloxy, Heteroraryloxy, Alkoxyalkoxy, Alkinylalkoxy, Alkenyloxy, Bis-alkylaminoalkoxy, Tris- [alkyl] silyl, Bis- [alkyl] arylsilyl, Bis- [alkyl] alkylsilyl, Tris- [alkyl] silylalkinyl, Alkylalkinyl, Cycloalkylalkinyl, Haloalkylalkinyl, Heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, The term "aryl" means an optionally substituted mono-, bi- or polycyclic aromatic system having preferably 6 to 14, in particular 6 to 10 ring C atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably phenyl. The term "optionally substituted aryl" also includes polycyclic systems, such as tetrahydronaphthyl, indenyl, indanyl, fluorenyl, biphenylyl, the binding site being on the aromatic system. "Aryl" is also generally known from the term "optionally Preferred aryl substituents here are, for example, hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkoxyalkyl, alkylthio, haloalkylthio, haloalkyl , Alkoxy, haloalkoxy, cycloalkoxy, cycloalkylalkoxy, aryloxy, heteroaryloxy, alkoxyalkoxy, alkynylalkoxy, alkenyloxy, bis-alkylaminoalkoxy, tris [alkyl] silyl, bis [alkyl] arylsilyl, bis [alkyl] alkylsilyl, tris [alkyl] silylalkynyl , Alkylalkynyl, cycloalkylalkynyl, haloalkylalkynyl, heterocyclyl-N-alkoxy, nitro, cyano, amino, alkylamino, bis-alkylamino,

Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkylcarbonylamino, cycloalkylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino,

Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Alkoxycarbonylalkylamino, arylalkoxycarbonylalkylamino, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, bis-alkylaminocarbonyl,

Heteroarylalkoxy, Arylalkoxy Heteroarylalkoxy, arylalkoxy

Ein heterocyclischer Rest (Heterocyclyl) enthält mindestens einen heterocyclischen Ring A heterocyclic radical (heterocyclyl) contains at least one heterocyclic ring

(=carbocyclischer Ring, in dem mindestens ein C-Atom durch ein Heteroatom ersetzt ist, vorzugsweise durch ein Heteroatom aus der Gruppe N, O, S, P) der gesättigt, ungesättigt, teilgesättigt oder heteroaromatisch ist und dabei unsubstituiert oder substituiert sein kann, wobei die Bindungsstelle an einem Ringatom lokalisiert ist. Ist der Heterocyclylrest oder der heterocyclische Ring gegebenenfalls substituiert, kann er mit anderen carbocyclischen oder heterocyclischen Ringen annelliert sein. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch mehrcyclische Systeme umfasst, wie beispielsweise 8-Aza-bicyclo[3.2.1]octanyl, 8-Aza-bicyclo[2.2.2]octanyl oder 1-Aza- bicyclo[2.2.1]heptyl. Im Falle von gegebenenfalls substituiertem Heterocyclyl werden auch (= carbocyclic ring in which at least one C atom is replaced by a heteroatom, preferably by a heteroatom from the group N, O, S, P) which is saturated, unsaturated, partially saturated or heteroaromatic and may be unsubstituted or substituted, wherein the binding site is located on a ring atom. When the heterocyclyl or heterocyclic ring is optionally substituted, it may be fused with other carbocyclic or heterocyclic rings. In the case of optionally substituted heterocyclyl, polycyclic systems are also included, for example 8-azabicyclo [3.2.1] octanyl, 8-azabicyclo [2.2.2] octanyl or 1-azabicyclo [2.2.1] heptyl. In the case of optionally substituted heterocyclyl also become

spirocyclische Systeme umfasst, wie beispielsweise l-Oxa-5-aza-spiro[2.3]hexyl. Wenn nicht anders definiert, enthält der heterocyclische Ring vorzugsweise 3 bis 9 Ringatome, insbesondere 3 bis 6 Ringatome, und ein oder mehrere, vorzugsweise 1 bis 4, insbesondere 1 , 2 oder 3 Heteroatome im heterocyclischen Ring, vorzugsweise aus der Gruppe N, O, und S, wobei jedoch nicht zwei spiro-cyclic systems such as 1-oxa-5-aza-spiro [2.3] hexyl. Unless defined otherwise, the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more, preferably 1 to 4, in particular 1, 2 or 3 heteroatoms in the heterocyclic ring, preferably from the group N, O, and S, but not two

Sauerstoffatome direkt benachbart sein sollen, wie beispielsweise mit einem Heteroatom aus der Gruppe N, O und S 1- oder 2- oder 3-Pyrrolidinyl, 3,4-Dihydro-2H-pyrrol-2- oder 3-yl, 2,3-Dihydro-lH-pyrrol- 1- oder 2- oder 3- oder 4- oder 5-yl; 2,5-Dihydro-lH-pyrrol-l - oder 2- oder 3-yl, 1- oder 2- oder 3- oder 4-Piperidinyl; 2,3,4,5-Tetrahydropyridin-2- oder 3- oder 4- oder 5-yl oder 6-yl; 1,2,3,6- Tetrahydropyridin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyridin-l- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4-Dihydropyridin-l - oder 2- oder 3- oder 4-yl; 2,3-Dihydropyridin- 2- oder 3- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyridin-2- oder 3- oder 4- oder 5- oder 6-yl, 1- oder 2- oder 3- oder 4-Azepanyl; 2,3,4,5-Tetrahydro-lH-azepin-l- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-lH-azepin-l- oder 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7- Tetrahydro-lH-azepin-1- oder 2- oder 3- oder 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-lH-azepin-l- oder 2- oder 3- oder 4-yl; 2,5-Dihydro-lH-azepin-Oxygen atoms are to be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4-dihydro-2H-pyrrol-2 or 3-yl, 2,3- Dihydro-1H-pyrrole 1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrol-1 - or 2- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5-tetrahydropyridine-2- or 3- or 4- or 5-yl or 6-yl; 1,2,3,6-tetrahydropyridine-1 or 2 or 3 or 4 or 5 or 6-yl; 1,2,3,4-tetrahydropyridine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,4-dihydropyridine-I - or 2- or 3- or 4-yl; 2,3-dihydropyridine-2 or 3 or 4 or 5 or 6-yl; 2,5-dihydropyridine-2- or 3- or 4- or 5- or 6-yl, 1- or 2- or 3- or 4-azepanyl; 2,3,4,5-tetrahydro-1H-azepine-1 or 2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,4,7-tetrahydro-1H-azepine-1 or 2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,6,7 Tetrahydro-1H-azepine-1 or 2- or 3- or 4-yl; 3,4,5,6-tetrahydro-2H-azepine-2 or 3 or 4 or 5 or 6 or 7-yl; 4,5-dihydro-1H-azepine-1 or 2 or 3 or 4-yl; 2,5-dihydro-lH-azepin-

1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-lH-azepin-l- oder -2- oder 3- oder 4- yl; 2,3-Dihydro-lH-azepin-l - oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,4-Dihydro-2H-azepin- 2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 5,6-Dihydro-2H-azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-3H-azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1H-azepine-1 or -2 or 3 or 4 yl; 2,3-dihydro-1H-azepine-1 or -2 or 3 or 4 or 5 or 6 or 7-yl; 3,4-dihydro-2H-azepine 2- or 3- or 4- or 5- or 6- or 7-yl; 3,6-dihydro-2H-azepine-2 or 3 or 4 or 5 or 6 or 7-yl; 5,6-dihydro-2H-azepine-2 or 3 or 4 or 5 or 6 or 7-yl; 4,5-dihydro-3H-azepine

2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 1H-Azepin-1- oder -2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 3H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4H-Azepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl, 2- oder 3-Oxolanyl (= 2- oder 3- Tetrahydrofuranyl); 2,3-Dihydrofüran-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrofüran-2- oder 3-yl, 2- oder 3- oder 4-Oxanyl (= 2- oder 3- oder 4-Tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-pyran-2- oder 3-oder 4- oder 5- oder 6-yl; 2H-Pyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Pyran-2- oder 3- oder 4-yl, 2- oder 3- oder 4-Oxepanyl; 2,3,4,5- Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydrooxepin-2- oder 3- oder 4-yl; 2,3-Dihydrooxepin-2- oder2- or 3- or 4- or 5- or 6- or 7-yl; 1H-azepine-1 or -2 or 3 or 4 or 5 or 6 or 7-yl; 2H-azepine-2- or 3- or 4- or 5- or 6- or 7-yl; 3H-azepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4H-azepine-2- or 3- or 4- or 5- or 6- or 7-yl, 2- or 3-oxolanyl (= 2- or 3-tetrahydrofuranyl); 2,3-dihydrofuran-2- or 3- or 4- or 5-yl; 2,5-dihydrofuran-2- or 3-yl, 2- or 3- or 4-oxanyl (= 2- or 3- or 4-tetrahydropyranyl); 3,4-dihydro-2H-pyran-2 or 3 or 4 or 5 or 6-yl; 3,6-dihydro-2H-pyran-2 or 3 or 4 or 5 or 6-yl; 2H-pyran-2- or 3- or 4- or 5- or 6-yl; 4H-pyran-2- or 3- or 4-yl, 2- or 3- or 4-oxepanyl; 2,3,4,5-tetrahydrooxepin-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,4,7-tetrahydrooxepin-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,6,7-tetrahydrooxepin-2 or 3 or 4-yl; 2,3-dihydrooxepin-2-or

3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydrooxepin-2- oder 3- oder 4-yl; 2,5-Dihydrooxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; Oxepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2- oder 3- Tetrahydrothiophenyl; 2,3-Dihydrothiophen-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydrothiophen-2- oder 3-yl; Tetrahydro-2H-thiopyran-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 2H-Thiopyran-2- oder 3- oder 4- oder 5- oder 6-yl; 4H-Thiopyran-2- oder 3- oder 4-yl. Bevorzugte 3-Ring und 4-Ring- Heterocyclen sind beispielsweise 1- oder 2-Aziridinyl, Oxiranyl, Thiiranyl, 1- oder 2- oder 3-Azetidinyl,3- or 4- or 5- or 6- or 7-yl; 4,5-dihydrooxepin-2 or 3 or 4-yl; 2,5-dihydrooxepin-2 or 3 or 4 or 5 or 6 or 7-yl; Oxepin-2 or 3 or 4 or 5 or 6 or 7-yl; 2- or 3-tetrahydrothiophenyl; 2,3-dihydrothiophene-2 or 3 or 4 or 5-yl; 2,5-dihydrothiophene-2 or 3-yl; Tetrahydro-2H-thiopyran-2- or 3- or 4-yl; 3,4-dihydro-2H-thiopyran-2 or 3 or 4 or 5 or 6-yl; 3,6-dihydro-2H-thiopyran-2 or 3 or 4 or 5 or 6-yl; 2H-thiopyran-2 or 3 or 4 or 5 or 6-yl; 4H-thiopyran-2- or 3- or 4-yl. Preferred 3-membered ring and 4-membered ring heterocycles are, for example, 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-azetidinyl,

2- oder 3-Oxetanyl, 2- oder 3-Thietanyl, l,3-Dioxetan-2-yl. Weitere Beispiele für "Heterocyclyl" sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit zwei Heteroatomen aus der Gruppe N, O und S, wie beispielsweise 1- oder 2- oder 3- oder 4-Pyrazolidinyl; 4,5-Dihydro-3H-pyrazol- 3- oder 4- oder 5-yl; 4,5-Dihydro-lH-pyrazol-l - oder 3- oder 4- oder 5-yl; 2,3-Dihydro-lH-pyrazol-l - oder 2- oder2- or 3-oxetanyl, 2- or 3-thietanyl, 1,3-dioxetan-2-yl. Further examples of "heterocyclyl" are a partially or fully hydrogenated heterocyclic radical having two heteroatoms from the group N, O and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazole-3 or 4 or 5-yl; 4,5-dihydro-1H-pyrazole-1 - or 3 or 4 or 5-yl; 2,3-dihydro-1H-pyrazole-1 - or 2 - or

3- oder 4- oder 5-yl; 1- oder 2- oder 3- oder 4- Imidazolidinyl; 2,3-Dihydro-lH-imidazol-l- oder 2- oder3- or 4- or 5-yl; 1- or 2- or 3- or 4-imidazolidinyl; 2,3-dihydro-1H-imidazole-I or 2- or

3- oder 4-yl; 2,5-Dihydro-lH-imidazol-l- oder 2- oder 4- oder 5-yl; 4,5-Dihydro-lH-imidazol-l- oder 2- oder 4- oder 5-yl; Hexahydropyridazin-1- oder 2- oder 3- oder 4-yl; 1,2,3,4-Tetrahydropyridazin-l- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2,3, 6-Tetrahydropyridazin-l- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,4,5, 6-Tetrahydropyridazin-l- oder 3- oder 4- oder 5- oder 6-yl; 3,4,5, 6-Tetrahydropyridazin-3- oder 4- oder 5-yl; 4,5-Dihydropyridazin-3- oder 4-yl; 3,4-Dihydropyridazin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydropyridazin-3- oder 4-yl; 1,6-Dihydropyriazin-l- oder 3- oder 4- oder 5- oder 6-yl; 3- or 4-yl; 2,5-dihydro-1H-imidazole-1- or 2- or 4- or 5-yl; 4,5-dihydro-1H-imidazole-1- or 2- or 4- or 5-yl; Hexahydropyridazine-1 or 2- or 3- or 4-yl; 1,2,3,4-tetrahydropyridazine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2,3,6-tetrahydropyridazine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,4,5,6-tetrahydropyridazine-1- or 3- or 4- or 5- or 6-yl; 3,4,5,6-tetrahydropyridazine-3- or 4- or 5-yl; 4,5-dihydropyridazine-3 or 4-yl; 3,4-dihydropyridazine-3- or 4- or 5- or 6-yl; 3,6-dihydropyridazine-3 or 4-yl; 1,6-dihydropyriazine-1- or 3- or 4- or 5- or 6-yl;

Hexahydropyrimidin-1- oder 2- oder 3- oder 4-yl; 1,4,5,6-Tetrahydropyrimidin-l- oder 2- oder 4- oder 5- oder 6-yl; 1,2,5,6-Tetrahydropyrimidin-l - oder 2- oder 4- oder 5- oder 6-yl; 1,2,3,4-Hexahydropyrimidine-1 or 2 or 3 or 4-yl; 1,4,5,6-tetrahydropyrimidine-1- or 2- or 4- or 5- or 6-yl; 1,2,5,6-tetrahydropyrimidine-1 - or 2- or 4- or 5- or 6-yl; 1,2,3,4

Tetrahydropyrimidin-1- oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,6-Dihydropyrimidin-l- oder 2- oderTetrahydropyrimidine-1 or 2 or 3 or 4 or 5 or 6-yl; 1,6-dihydropyrimidine-I or 2- or

4- oder 5- oder 6-yl; 1,2-Dihydropyrimidin-l - oder 2- oder 4- oder 5- oder 6-yl; 2,5-Dihydropyrimidin- 2- oder 4- oder 5-yl; 4,5-Dihydropyrimidin- 4- oder 5- oder 6-yl; 1,4-Dihydropyrimidin-l- oder 2- oder 4- oder 5- oder 6-yl; 1- oder 2- oder 3-Piperazinyl; 1,2,3,6-Tetrahydropyrazin-l- oder 2- oder 3- oder 5- oder 6-yl; 1,2,3,4-Tetrahydropyrazin-l - oder 2- oder 3- oder 4- oder 5- oder 6-yl; 1,2-Dihydropyrazin-l- oder 2- oder 3- oder 5- oder 6-yl; 1,4-Dihydropyrazin-l - oder 2- oder 3-yl; 2,3-Dihydropyrazin-2- oder 3- oder 5- oder 6-yl; 2,5-Dihydropyrazin-2- oder 3-yl; l,3-Dioxolan-2- oder 4- oder 5-yl; l,3-Dioxol-2- oder 4-yl; l,3-Dioxan-2- oder 4- oder 5-yl; 4H-l,3-Dioxin-2- oder 4- oder 5- oder 6-yl; l,4-Dioxan-2- oder 3- oder 5- oder 6-yl; 2,3-Dihydro-l,4-dioxin-2- oder 3- oder 5- oder 6-yl; l,4-Dioxin-2- oder 3-yl;4- or 5- or 6-yl; 1,2-dihydropyrimidine-1 - or 2- or 4- or 5- or 6-yl; 2,5-dihydropyrimidine 2- or 4- or 5-yl; 4,5-dihydropyrimidine-4- or 5- or 6-yl; 1,4-dihydropyrimidine-1- or 2- or 4- or 5- or 6-yl; 1- or 2- or 3-piperazinyl; 1,2,3,6-tetrahydropyrazine-1- or 2- or 3- or 5- or 6-yl; 1,2,3,4-tetrahydropyrazine-1 - or 2- or 3- or 4- or 5- or 6-yl; 1,2-dihydropyrazine 1- or 2- or 3- or 5- or 6-yl; 1,4-dihydropyrazine-1 - or 2- or 3-yl; 2,3-dihydropyrazine-2- or 3- or 5- or 6-yl; 2,5-dihydropyrazine-2 or 3-yl; l, 3-dioxolane-2- or 4- or 5-yl; l, 3-dioxol-2 or 4-yl; 1, 3-dioxan-2 or 4 or 5-yl; 4H-l, 3-dioxin-2 or 4 or 5 or 6-yl; 1, 4-dioxane-2 or 3 or 5 or 6-yl; 2,3-dihydro-1,4-dioxin-2- or 3- or 5- or 6-yl; l, 4-dioxin-2 or 3-yl;

1.2- Dithiolan-3- oder 4-yl; 3H-l,2-Dithiol-3- oder 4- oder 5-yl; l,3-Dithiolan-2- oder 4-yl; 1,3-Dithiol- 2- oder 4-yl; l,2-Dithian-3- oder 4-yl; 3,4-Dihydro-l,2-dithiin-3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro- l,2-dithiin-3- oder 4-yl; l,2-Dithiin-3- oder 4-yl; l,3-Dithian-2- oder 4- oder 5-yl; 4H-l,3-Dithiin-2- oder 4- oder 5- oder 6-yl; Isoxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 2,5-Dihydroisoxazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisoxazol-3- oder 4- oder 5-yl;1,2-dithiolan-3 or 4-yl; 3H-1,2-dithiol-3- or 4- or 5-yl; l, 3-dithiolan-2 or 4-yl; 1,3-dithiol-2- or 4-yl; 1, 2-dithian-3 or 4-yl; 3,4-dihydro-1,2-dithiin-3 or 4 or 5 or 6-yl; 3,6-dihydro-l, 2-dithiin-3 or 4-yl; l, 2-dithiin-3 or 4-yl; l, 3-dithian-2 or 4 or 5-yl; 4H-l, 3-dithiin-2 or 4 or 5 or 6-yl; Isoxazolidine-2 or 3 or 4 or 5-yl; 2,3-dihydroisoxazole-2 or 3 or 4 or 5-yl; 2,5-dihydroisoxazole-2 or 3 or 4 or 5-yl; 4,5-dihydroisoxazole-3 or 4 or 5-yl;

1.3- Oxazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-l,3-oxazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-l,3-oxazol-2- oder 4- oder 5-yl; 4,5-Dihydro-l,3-oxazol-2- oder 4- oder 5-yl; l,2-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-l,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-l,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-l,2-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-l,2-oxazin-3- oder 4- oder 5- oder 6-yl; 2H-l,2-Oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 6H-l,2-Oxazin-3- oder 4- oder 5- oder 6-yl; 4H-l,2-Oxazin-3- oder 4- oder 5- oder 6-yl; l,3-Oxazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-l,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-l,3-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H- l,3-oxazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-l,3-oxazin-2- oder 4- oder 5- oder 6-yl; 2H- l,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 6H-l,3-Oxazin-2- oder 4- oder 5- oder 6-yl; 4H-l,3-Oxazin-2- oder 4- oder 5- oder 6-yl; Morpholin-2- oder 3- oder 4-yl; 3,4-Dihydro-2H-l,4-oxazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6-Dihydro-2H-l,4-oxazin-2- oder 3- oder 5- oder 6-yl; 2H-l,4-oxazin-2- oder 3- oder 5- oder 6-yl; 4H-l,4-oxazin-2- oder 3-yl; 1 ,2-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,3,4,5-Tetrahydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-l,2- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-l,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-l,2-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-l,2- oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-l,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-l,2-oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; l,2-Oxazepin-3- oder 4- oder 5- oder 6- oder 7-yl; l,3-Oxazepan-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-l,3- oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7-Tetrahydro-l,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-l,3-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 2,5,6,7-Tetrahydro-l,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,5,6,7-Tetrahydro-l,3- oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-l,3-oxazepin-2- oder 3- oder 4- oder 5- oder1.3 oxazolidine-2- or 3- or 4- or 5-yl; 2,3-dihydro-1,3-oxazol-2 or 3 or 4 or 5-yl; 2,5-dihydro-1,3-oxazol-2 or 4 or 5-yl; 4,5-dihydro-1,3-oxazol-2 or 4 or 5-yl; 1, 2-oxazinan-2 or 3 or 4 or 5 or 6-yl; 3,4-dihydro-2H-1,2-oxazine-2 or 3 or 4 or 5 or 6-yl; 3,6-dihydro-2H-1,2-oxazine-2 or 3 or 4 or 5 or 6-yl; 5,6-dihydro-2H-1,2-oxazine-2 or 3 or 4 or 5 or 6-yl; 5,6-dihydro-4H-1,2-oxazine-3 or 4 or 5 or 6-yl; 2H-l, 2-oxazine-2 or 3 or 4 or 5 or 6-yl; 6H-l, 2-oxazine-3 or 4 or 5 or 6-yl; 4H-1, 2-oxazine-3 or 4 or 5 or 6-yl; l, 3-oxazinan-2 or 3 or 4 or 5 or 6-yl; 3,4-dihydro-2H-1,3-oxazine-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,3-oxazine-2 or 3 or 4 or 5 or 6-yl; 5,6-dihydro-2H-1,3-oxazine-2- or 4- or 5- or 6-yl; 5,6-dihydro-4H-1,3-oxazine-2- or 4- or 5- or 6-yl; 2H-, 3-oxazine-2- or 4- or 5- or 6-yl; 6H-1, 3-oxazine-2 or 4 or 5 or 6-yl; 4H-1, 3-oxazine-2 or 4 or 5 or 6-yl; Morpholine-2- or 3- or 4-yl; 3,4-dihydro-2H-1,4-oxazine-2- or 3- or 4- or 5- or 6-yl; 3,6-dihydro-2H-1,4-oxazine-2- or 3- or 5- or 6-yl; 2H-1,4-oxazine-2- or 3- or 5- or 6-yl; 4H-1,4-oxazine-2 or 3-yl; 1, 2-oxazepan-2 or 3 or 4 or 5 or 6 or 7 yl; 2,3,4,5-tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1, 2-oxazepine-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,6,7-tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 2,3-dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1,2-oxazepine-2 or 3 or 4 or 5 or 6 or 7-yl; 4,5-dihydro-1, 2-oxazepine-3 or 4 or 5 or 6 or 7-yl; 4,7-dihydro-1,2-oxazepine-3 or 4 or 5 or 6 or 7-yl; 6,7-dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 1, 2-oxazepine-3 or 4 or 5 or 6 or 7-yl; l, 3-oxazepan-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,4,5-tetrahydro-1, 3-oxazepine-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,4,7-tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-l, 3- oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,3-dihydro-1,3-oxazepine-2 or 3 or 4 or 5 or

6- oder 7-yl; 2,5-Dihydro-l,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 2,7-Dihydro-l,3-oxazepin- 2- oder 4- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-l,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 4,7- Dihydro-l,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-l,3-oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; l,3-Oxazepin-2- oder 4- oder 5- oder 6- oder 7-yl; 1 ,4-Oxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3,4,5-Tetrahydro-l,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,4,7- Tetrahydro-l,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3,6,7-Tetrahydro-l,4-oxazepin-6- or 7-yl; 2,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,7-dihydro-1,3-oxazepine 2- or 4- or 5- or 6- or 7-yl; 4,5-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 6,7-dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; l, 3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,4-oxazepan-2- or 3- or 5- or 6- or 7-yl; 2,3,4,5-tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-l, 4-oxazepine-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3,6,7-tetrahydro-l, 4-oxazepin

2- oder 3- oder 5- oder 6- oder 7-yl; 2,5,6,7-Tetrahydro-l,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7- yl; 4,5,6,7-Tetrahydro-l,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-l,4- oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,5-Dihydro-l,4-oxazepin-2- oder 3- oder 5- oder 6- oder2- or 3- or 5- or 6- or 7-yl; 2,5,6,7-tetrahydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 4,5,6,7-tetrahydro-l, 4-oxazepine-2 or 3 or 4 or 5 or 6 or 7-yl; 2,3-dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,5-dihydro-l, 4-oxazepine-2 or 3 or 5 or 6 or

7- yl; 2,7-Dihydro-l,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 4,5-Dihydro-l,4-oxazepin-2- oder7- yl; 2,7-dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 4,5-dihydro-1,4-oxazepine-2- or

3- oder 4- oder 5- oder 6- oder 7-yl; 4,7-Dihydro-l,4-oxazepin-2- oder 3- oder 4- oder 5- oder 6- oder 7- yl; 6,7-Dihydro-l,4-oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 1 ,4-Oxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; Isothiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydroisothiazol-2- oder 3- oder 4- oder 5- yl; 2,5-Dihydroisothiazol-2- oder 3- oder 4- oder 5-yl; 4,5-Dihydroisothiazol-3- oder 4- oder 5-yl; 1,3- Thiazolidin-2- oder 3- oder 4- oder 5-yl; 2,3-Dihydro-l ,3-thiazol-2- oder 3- oder 4- oder 5-yl; 2,5- Dihydro-l,3-thiazol-2- oder 4- oder 5-yl; 4,5-Dihydro-l,3-thiazol-2- oder 4- oder 5-yl; l,3-Thiazinan-2- oder 3- oder 4- oder 5- oder 6-yl; 3,4-Dihydro-2H-l,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 3,6- Dihydro-2H-l,3-thiazin-2- oder 3- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-2H-l,3-thiazin-2- oder 4- oder 5- oder 6-yl; 5,6-Dihydro-4H-l,3-thiazin-2- oder 4- oder 5- oder 6-yl; 2H-l,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 6H-l,3-Thiazin-2- oder 4- oder 5- oder 6-yl; 4H-l,3-Thiazin-2- oder 4- oder 5- oder 6-yl. Weitere Beispiele für "Heterocyclyl" sind ein partiell oder vollständig hydrierter heterocyclischer Rest mit 3 Heteroatomen aus der Gruppe N, O und S, wie beispielsweise l,4,2-Dioxazolidin-2- oder 3- oder 5-yl; l,4,2-Dioxazol-3- oder 5-yl; 1 ,4,2-Dioxazinan-2- oder -3- oder 5- oder 6-yl; 5,6-Dihydro-l,4,2- dioxazin-3- oder 5- oder 6-yl; l,4,2-Dioxazin-3- oder 5- oder 6-yl; l,4,2-Dioxazepan-2- oder 3- oder 5- oder 6- oder 7-yl; 6,7-Dihydro-5H-l,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-7H-l,4,2- Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 2,3-Dihydro-5H-l,4,2-Dioxazepin-2- oder 3- oder 5- oder 6- oder 7-yl; 5H-l,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl; 7H-l,4,2-Dioxazepin-3- oder 5- oder 6- oder 7-yl. Strukturbeispiele für gegebenenfalls weiter substituierte Heterocyclen sind auch im Folgenden aufgeführt: 3- or 4- or 5- or 6- or 7-yl; 4,7-dihydro-l, 4-oxazepine-2 or 3 or 4 or 5 or 6 or 7 yl; 6,7-dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; Isothiazolidine-2- or 3- or 4- or 5-yl; 2,3-dihydroisothiazole-2 or 3 or 4 or 5 yl; 2,5-dihydroisothiazole-2 or 3 or 4 or 5-yl; 4,5-dihydroisothiazole-3 or 4 or 5-yl; 1,3-thiazolidine-2- or 3- or 4- or 5-yl; 2,3-dihydro-1,3-thiazole-2 or 3 or 4 or 5-yl; 2,5-dihydro-1,3-thiazol-2 or 4 or 5-yl; 4,5-dihydro-1,3-thiazol-2 or 4 or 5-yl; l, 3-thiazinan-2 or 3 or 4 or 5 or 6-yl; 3,4-dihydro-2H-1, 3-thiazine-2 or 3 or 4 or 5 or 6-yl; 3,6-dihydro-2H-l, 3-thiazine-2 or 3 or 4 or 5 or 6-yl; 5,6-dihydro-2H-1, 3-thiazine-2 or 4 or 5 or 6-yl; 5,6-dihydro-4H-1, 3-thiazine-2 or 4 or 5 or 6-yl; 2H-1, 3-thiazine-2 or 4 or 5 or 6-yl; 6H-l, 3-thiazine-2 or 4 or 5 or 6-yl; 4H-l, 3-thiazine-2 or 4 or 5 or 6-yl. Further examples of "heterocyclyl" are a partially or fully hydrogenated heterocyclic radical having 3 heteroatoms from the group N, O and S, such as, for example, l, 4,2-dioxazolidin-2 or 3 or 5-yl; l, 4,2-dioxazol-3 or 5-yl; 1,2,2-dioxazinane-2- or -3- or 5- or 6-yl; 5,6-dihydro-l, 4,2-dioxazine-3 or 5 or 6-yl; l, 4,2-dioxazine-3- or 5- or 6-yl; l, 4,2-dioxazepan-2 or 3 or 5 or 6 or 7-yl; 6,7-dihydro-5H-l, 4,2-dioxazepine-3 or 5 or 6 or 7-yl; 2,3-dihydro-7H-l, 4,2-dioxazepin-2 or 3 or 5 or 6 or 7-yl; 2,3-dihydro-5H-1, 4,2-dioxazepine-2 or 3 or 5 or 6 or 7-yl; 5H-l, 4,2-dioxazepine-3 or 5 or 6 or 7-yl; 7H-l, 4,2-dioxazepine-3 or 5 or 6 or 7-yl. Structural examples of optionally further substituted heterocycles are also listed below:

X) 3 X)  X) 3 X ) 

Figure imgf000036_0001
Figure imgf000036_0001

Figure imgf000037_0001
Figure imgf000037_0001

Die oben aufgeführten Heterocyclen sind bevorzugt beispielsweise durch Wasserstoff, Halogen, Alkyl, Haloalkyl, Hydroxy, Alkoxy, Cycloalkoxy, Aryloxy, Alkoxyalkyl, Alkoxyalkoxy, Cycloalkyl, Halocycloalkyl, Aryl, Arylalkyl, Heteroaryl, Heterocyclyl, Alkenyl, Alkylcarbonyl, Cycloalkylcarbonyl, Arylcarbonyl, Heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, The heterocycles listed above are preferably, for example, hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, cycloalkoxy, aryloxy, alkoxyalkyl, alkoxyalkoxy, cycloalkyl, Halocycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclyl, alkenyl, alkylcarbonyl, cycloalkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, hydroxycarbonyl, cycloalkoxycarbonyl,

Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkinyl, Alkinylalkyl, Alkylalkinyl, Tris-alkylsilylalkinyl, Nitro, Amino, Cyano, Haloalkoxy, Cycloalkylalkoxycarbonyl, alkoxycarbonylalkyl, arylalkoxycarbonyl, arylalkoxycarbonylalkyl, alkynyl, alkynylalkyl, alkylalkynyl, trisalkylsilylalkynyl, nitro, amino, cyano, haloalkoxy,

Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Haloalkylthio, alkylthio, hydrothio, hydroxyalkyl, oxo, heteroarylalkoxy, arylalkoxy,

Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis- alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Alkoxycarbonylalkyl(alkyl)amino, Aminocarbonyl,  Heterocyclylalkoxy, heterocyclylalkylthio, heterocyclyloxy, heterocyclylthio, heteroaryloxy, bisalkylamino, alkylamino, cycloalkylamino, hydroxycarbonylalkylamino, alkoxycarbonylalkylamino, arylalkoxycarbonylalkylamino, alkoxycarbonylalkyl (alkyl) amino, aminocarbonyl,

Alkylaminocarbonyl, Bis-alkylaminocarbonyl, Cycloalkylaminocarbonyl, Alkylaminocarbonyl, bis-alkylaminocarbonyl, cycloalkylaminocarbonyl,

Hydroxycarbonylalkylaminocarbonyl, Alkoxycarbonylalkylaminocarbonyl, Hydroxycarbonylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl,

Arylalkoxycarbonylalkylaminocarbonyl substituiert. Arylalkoxycarbonylalkylaminocarbonyl substituted.

Wenn ein Grundkörper "durch einen oder mehrere Reste" aus einer Aufzählung von Resten (= Gruppe) oder einer generisch definierten Gruppe von Resten substituiert ist, so schließt dies jeweils die gleichzeitige Substitution durch mehrere gleiche und/oder strukturell unterschiedliche Reste ein. If a main body is "substituted by one or more radicals" from an enumeration of radicals (= group) or a generically defined group of radicals, this includes the simultaneous substitution by a plurality of identical and / or structurally different radicals.

Handelt es sich es sich um einen teilweise oder vollständig gesättigten Stickstoff-Heterocyclus, so kann dieser sowohl über Kohlenstoff als auch über den Stickstoff mit dem Rest des Moleküls verknüpft sein. Als Substituenten für einen substituierten heterocyclischen Rest kommen die weiter unten genanntenIf it is a partially or fully saturated nitrogen heterocycle, it may be linked to the rest of the molecule via both carbon and nitrogen. Substituents for a substituted heterocyclic radical are those mentioned below

Substituenten in Frage, zusätzlich auch Oxo und Thioxo. Die Oxogruppe als Substituent an einem Ring- C-Atom bedeutet dann beispielsweise eine Carbonylgruppe im heterocyclischen Ring. Dadurch sind vorzugsweise auch Lactone und Lactame umfasst. Die Oxogruppe kann auch an den Heteroringatomen, die in verschiedenen Oxidationsstufen existieren können, z.B. bei N und S, auftreten und bilden dann beispielsweise die divalenten Gruppen N(O) , S(O) (auch kurz SO) und S(0)2 (auch kurz SO2) im heterocyclischen Ring. Im Fall von -N(O)- und -S(0)-Gruppen sind jeweils beide Enantiomere umfasst. Substituents in question, in addition also oxo and thioxo. The oxo group as a substituent on a ring C atom then means, for example, a carbonyl group in the heterocyclic ring. As a result, lactones and lactams are preferably also included. The oxo group may also be attached to the hetero ring atoms, which may exist in different oxidation states, e.g. For example, at N and S, the divalent groups N (O), S (O) (also SO for short) and S (O) 2 (also SO2 for short) occur and form in the heterocyclic ring. In the case of -N (O) and -S (0) groups, both enantiomers are included.

Erfindungsgemäß steht der Ausdruck„Heteroaryl" für heteroaromatische Verbindungen, d. h. According to the invention, the term "heteroaryl" stands for heteroaromatic compounds, ie.

vollständig ungesättigte aromatische heterocyclische Verbindungen, vorzugsweise für 5- bis 7-gliedrige Ringe mit 1 bis 4, vorzugsweise 1 oder 2 gleichen oder verschiedenen Heteroatomen, vorzugsweise O, S oder N. Erfindungsgemäße Heteroaryle sind beispielsweise lH-Pyrrol-l-yl; lH-Pyrrol-2-yl; lH-Pyrrol-completely unsaturated aromatic heterocyclic compounds, preferably for 5- to 7-membered rings having 1 to 4, preferably 1 or 2 identical or different heteroatoms, preferably O, S or N. Heteroaryls according to the invention are, for example, 1H-pyrrol-1-yl; lH-pyrrol-2-yl; lH-pyrrole

3- yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, lH-Imidazol-l -yl; lH-Imidazol-2-yl; lH-Imidazol-3-yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, 1H-imidazol-1-yl; lH-imidazol-2-yl; lH-imidazole

4- yl; lH-Imidazol-5-yl; lH-Pyrazol-l-yl; lH-Pyrazol-3-yl; lH-Pyrazol-4-yl; lH-Pyrazol-5-yl, 1H-1,2,3- Triazol-l-yl, lH-l,2,3-Triazol-4-yl, lH-l,2,3-Triazol-5-yl, 2H-l,2,3-Triazol-2-yl, 2H-l,2,3-Triazol-4-yl, lH-l,2,4-Triazol-l-yl, lH-l,2,4-Triazol-3-yl, 4H-l,2,4-Triazol-4-yl, l,2,4-Oxadiazol-3-yl, 1,2,4- Oxadiazol-5-yl, l,3,4-Oxadiazol-2-yl, l,2,3-Oxadiazol-4-yl, l,2,3-Oxadiazol-5-yl, l ,2,5-Oxadiazol-3-yl, Azepinyl, Pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, 4-yl; lH-imidazol-5-yl; lH-pyrazol-l-yl; lH-pyrazol-3-yl; lH-pyrazol-4-yl; lH-pyrazol-5-yl, 1H-1,2,3-triazol-1-yl, 1H-l, 2,3-triazol-4-yl, 1H-l, 2,3-triazol-5-yl, 2H-l, 2,3-triazol-2-yl, 2H-l, 2,3-triazol-4-yl, 1H-l, 2,4-triazol-1-yl, 1H-l, 2,4- Triazol-3-yl, 4H-l, 2,4-triazol-4-yl, l, 2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, l, 3,4- Oxadiazol-2-yl, l, 2,3-oxadiazol-4-yl, l, 2,3-oxadiazol-5-yl, l, 2,5-oxadiazol-3-yl, Azepinyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrazine-2-yl, pyrazine-3-yl, pyrimidin-2-yl,

Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin-4-yl, l,3,5-Triazin-2-yl, l ,2,4-Triazin-3-yl, l,2,4-Triazin-5-yl, 1 ,2,4-Triazin-6-yl, l,2,3-Triazin-4-yl, l,2,3-Triazin-5-yl, 1 ,2,4-, 1,3,2-, 1,3,6- und 1,2,6-Oxazinyl, Isoxazol-3-yl, Isoxazol-4-yl, Isoxazol-5-yl, l,3-Oxazol-2-yl, l,3-Oxazol-4-yl, 1,3- Oxazol-5-yl, Isothiazol-3-yl, Isothiazol-4-yl, Isothiazol-5-yl, l,3-Thiazol-2-yl, l,3-Thiazol-4-yl, 1,3- Thiazol-5-yl, Oxepinyl, Thiepinyl, 1 ,2,4-Triazolonyl und 1 ,2,4-Diazepinyl, 2H-l,2,3,4-Tetrazol-5-yl, lH-l,2,3,4-Tetrazol-5-yl, l,2,3,4-Oxatriazol-5-yl, l,2,3,4-Thiatriazol-5-yl, l,2,3,5-Oxatriazol-4-yl, l,2,3,5-Thiatriazol-4-yl. Die erfindungsgemäßen Heteroarylgruppen können ferner mit einem oder mehreren, gleichen oder verschiedenen Resten substituiert sein. Sind zwei benachbarte Pyrimidin-4-yl, pyrimidin-5-yl, pyridazin-3-yl, pyridazin-4-yl, l, 3,5-triazin-2-yl, l, 2,4-triazin-3-yl, 2,4-triazin-5-yl, 1, 2,4-triazin-6-yl, l, 2,3-triazin-4-yl, l, 2,3-triazin-5-yl, 1, 2, 4-, 1,3,2-, 1,3,6- and 1,2,6-oxazinyl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, 1,3-oxazole-2 -yl, 1,3-oxazol-4-yl, 1,3-oxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, l, 3-thiazol-2-yl , 1, 3-Thiazol-4-yl, 1,3-thiazol-5-yl, oxepinyl, thiepinyl, 1, 2,4-triazolonyl and 1, 2,4-diazepinyl, 2H-l, 2,3,4 -Tetrazol-5-yl, 1H-l, 2,3,4-tetrazol-5-yl, l, 2,3,4-oxatriazol-5-yl, l, 2,3,4-thiatriazol-5-yl 1,2,3,5-Oxatriazol-4-yl, 1,2,3,5-thiatriazol-4-yl. The heteroaryl groups according to the invention may furthermore be substituted by one or more identical or different radicals. Are two neighbors

Kohlenstoffatome Bestandteil eines weiteren aromatischen Rings, so handelt es sich um annellierte heteroaromatische Systeme, wie benzokondensierte oder mehrfach annellierte Heteroaromaten. Carbon atoms part of another aromatic ring, they are fused heteroaromatic systems, such as benzo-fused or multiply fused heteroaromatic.

Bevorzugt sind beispielsweise Chinoline (z. B. Chinolin-2-yl, Chinolin-3-yl, Chinolin-4-yl, Chinolin-5- yl, Chinolin-6-yl, Chinolin-7-yl, Chinolin-8-yl); Isochinoline (z. B. Isochinolin-l -yl, Isochinolin-3-yl, Isochinolin-4-yl, Isochinolin-5-yl, Isochinolin-6-yl, Isochinolin-7-yl, Isochinolin-8-yl); Chinoxalin; Chinazolin; Cinnolin; 1,5-Naphthyridin; 1 ,6-Naphthyridin; 1 ,7-Naphthyridin; 1,8-Naphthyridin; 2,6- Naphthyridin; 2,7-Naphthyridin; Phthalazin; Pyridopyrazine; Pyridopyrimidine; Pyridopyridazine; Pteridine; Pyrimidopyrimidine. Beispiele für Heteroaryl sind auch 5- oder 6-gliedrige benzokondensierte Ringe aus der Gruppe lH-Indol-l-yl, lH-Indol-2-yl, lH-Indol-3-yl, lH-Indol-4-yl, lH-Indol-5-yl, 1H- Indol-6-yl, lH-Indol-7-yl, l-Benzofuran-2-yl, l-Benzofuran-3-yl, l-Benzofuran-4-yl, l-Benzofuran-5- yl, l-Benzofuran-6-yl, l-Benzofuran-7-yl, l-Benzothiophen-2-yl, l-Benzothiophen-3-yl, 1-Preferred are, for example, quinolines (e.g., quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl ); Isoquinolines (e.g., isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl, isoquinolin-8-yl); quinoxaline; quinazoline; cinnoline; 1,5-naphthyridine; 1,6-naphthyridine; 1,7-naphthyridine; 1,8-naphthyridine; 2,6-naphthyridine; 2,7-naphthyridine; phthalazine; Pyridopyrazine; pyridopyrimidines; Pyridopyridazine; pteridines; Pyrimidopyrimidine. Examples of heteroaryl are also 5- or 6-membered benzo-fused rings from the group 1H-indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H- Indol-5-yl, 1H-indol-6-yl, 1H-indol-7-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran 5-yl, 1-benzofuran-6-yl, 1-benzofuran-7-yl, 1-benzothiophen-2-yl, 1-benzothiophen-3-yl, 1

Benzothiophen-4-yl, l-Benzothiophen-5-yl, l-Benzothiophen-6-yl, l-Benzothiophen-7-yl, lH-Indazol-Benzothiophen-4-yl, 1-benzothiophene-5-yl, 1-benzothiophene-6-yl, 1-benzothiophene-7-yl, 1H-indazole

1- yl, lH-Indazol-3-yl, lH-Indazol-4-yl, lH-Indazol-5-yl, lH-Indazol-6-yl, lH-Indazol-7-yl, 2H-Indazol-1-yl, 1H-indazol-3-yl, 1H-indazol-4-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 1H-indazol-7-yl, 2H-indazole

2- yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H- Isoindol-2-yl, 2H-Isoindol-l-yl, 2H-Isoindol-3-yl, 2H-Isoindol-4-yl, 2H-Isoindol-5-yl, 2H-Isoindol-6-yl; 2H-Isoindol-7-yl, lH-Benzimidazol-l-yl, lH-Benzimidazol-2-yl, lH-Benzimidazol-4-yl, 1H- Benzimidazol-5-yl, lH-Benzimidazol-6-yl, lH-Benzimidazol-7-yl, l,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, l,3-Benzoxazol-5-yl, l,3-Benzoxazol-6-yl, l,3-Benzoxazol-7-yl, l,3-Benzthiazol-2-yl, l,3-Benzthiazol-4-yl, l,3-Benzthiazol-5-yl, l,3-Benzthiazol-6-yl, l,3-Benzthiazol-7-yl, 1,2- Benzisoxazol-3-yl, l,2-Benzisoxazol-4-yl, l,2-Benzisoxazol-5-yl, l,2-Benzisoxazol-6-yl, 1,2- Benzisoxazol-7-yl, l,2-Benzisothiazol-3-yl, l,2-Benzisothiazol-4-yl, l,2-Benzisothiazol-5-yl, 1,2- Benzisothiazol-6-yl, 1 ,2-Benzisothiazol-7-yl. 2-yl, 2H-indazol-3-yl, 2H-indazol-4-yl, 2H-indazol-5-yl, 2H-indazol-6-yl, 2H-indazol-7-yl, 2H-isoindole-2 yl, 2H-isoindol-1-yl, 2H-isoindol-3-yl, 2H-isoindol-4-yl, 2H-isoindol-5-yl, 2H-isoindol-6-yl; 2H-isoindol-7-yl, 1H-benzimidazol-1-yl, 1H-benzimidazol-2-yl, 1H-benzimidazol-4-yl, 1H-benzimidazol-5-yl, 1H-benzimidazol-6-yl, 1H- Benzimidazol-7-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-4-yl, 1,3-benzoxazol-5-yl, 1,3-benzoxazol-6-yl, l, 3 Benzoxazol-7-yl, 1,3-benzthiazol-2-yl, 1,3-benzthiazol-4-yl, 1,3-benzthiazol-5-yl, 1,3-benzthiazol-6-yl, l, 3 Benzothiazol-7-yl, 1,2-benzisoxazol-3-yl, 1,2-benzisoxazol-4-yl, 1,2-benzisoxazol-5-yl, 1,2-benzisoxazol-6-yl, 1,2- Benzisoxazol-7-yl, 1,2-benzisothiazol-3-yl, 1,2-benzisothiazol-4-yl, 1,2-benzisothiazol-5-yl, 1,2-benzisothiazol-6-yl, 1, 2 benzisothiazol-7-yl.

Die Bezeichnung "Halogen" bedeutet beispielsweise Fluor, Chlor, Brom oder Iod. Wird die The term "halogen" means, for example, fluorine, chlorine, bromine or iodine. Will the

Bezeichnung für einen Rest verwendet, dann bedeutet "Halogen" beispielsweise ein Fluor-, Chlor-, Brom- oder Iodatom. When used to denote a radical, then "halogen" means, for example, a fluorine, chlorine, bromine or iodine atom.

Erfindungsgemäß bedeutet„Alkyl" einen geradkettigen oder verzweigten offenkettigen, gesättigten Kohlenwasserstoffrest, der gegebenenfalls ein- oder mehrfach substituiert ist und im letzteren Falle als „substituiertes Alkyl" bezeichnet wird. Bevorzugte Substituenten sind Halogenatome, Alkoxy-, Haloalkoxy-, Cyano-, Alkylthio, Haloalkylthio-, Amino- oder Nitrogruppen, besonders bevorzugt sind Methoxy, Methyl, Fluoralkyl, Cyano, Nitro, Fluor, Chlor, Brom oder Iod. Die Vorsilbe„Bis" schließt auch die Kombination unterschiedlicher Alkylreste ein, z. B. Methyl(Ethyl) oder Ethyl(Methyl). According to the invention, "alkyl" means a straight-chain or branched, open-chain, saturated Hydrocarbon radical which is optionally monosubstituted or polysubstituted and which is referred to in the latter case as "substituted alkyl." Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino or nitro groups, particular preference is given to methoxy , Methyl, fluoroalkyl, cyano, nitro, fluoro, chloro, bromo or iodo. The prefix "bis" also includes the combination of different alkyl radicals, e.g. For example, methyl (ethyl) or ethyl (methyl).

„Haloalkyl", ,,-alkenyl" und„-alkinyl" bedeuten durch gleiche oder verschiedene Halogenatome, teilweise oder vollständig substituiertes Alkyl, Alkenyl bzw. Alkinyl, z.B. Monohaloalkyl "Haloalkyl", "- alkenyl" and "alkynyl" mean by the same or different halogen atoms, partially or fully substituted alkyl, alkenyl and alkynyl, for example monohaloalkyl

(= Monohalogenalkyl) wie z. B. CH2CH2C1, CH2CH2Br, CHC1CH3, CH2C1, CH2F; Perhaloalkyl wie z. B. CCI3, CC1F2, CFC12,CF2CC1F2, CF2CC1FCF3; Polyhaloalkyl wie z. B. CH2CHFC1, CF2CC1FH, CF2CBrFH, CH2CF3; Der Begriff Perhaloalkyl umfasst dabei auch den Begriff Perfluoralkyl. (= Monohaloalkyl) such. CH 2 CH 2 Cl, CH 2 CH 2 Br, CHClCH 3 , CH 2 Cl, CH 2 F; Perhaloalkyl such. B. CCl 3, CC1F 2, CFC1 2 CF 2 CC1F 2, CF 2 CC1FCF 3; Polyhaloalkyl such. CH 2 CHFC1, CF 2 CC1FH, CF 2 CBrFH, CH 2 CF 3; The term perhaloalkyl also encompasses the term perfluoroalkyl.

„Teilfluoriertes Alkyl" bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der einfach oder mehrfach durch Fluor substituiert ist, wobei sich die entsprechenden Fluoratome als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden können, wie z. B. CHFCH3, CH2CH2F, CH2CH2CF3, CHF2, CH2F, CHFCF2CF3 "Partially fluorinated alkyl" means a straight-chain or branched, saturated hydrocarbon which is monosubstituted or polysubstituted by fluorine, it being possible for the corresponding fluorine atoms to be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain, for example CHFCH3, CH 2 CH 2 F, CH 2 CH 2 CF 3, CHF 2, CH 2 F, CF 3 CHFCF 2

„Teilfluoriertes Haloalkyl" bedeutet einen geradkettigen oder verzweigten, gesättigten "Partially fluorinated haloalkyl" means a straight-chain or branched, saturated one

Kohlenwasserstoff, der durch verschiedenene Halogenatomen mit mindestens einem Fluoratom substituiert ist, wobei alle anderen gegebenenfalls vorhandenen Halogenatome ausgewählt sind aus der Gruppe Fluor, Chlor oder Brom, Iod. Die entsprechenden Halogenatome können sich dabei als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden. Teilfluoriertes Haloalkyl schließt auch die vollständige Substitution der geradkettigen oder verzweigten Kette durch Halogen unter Beteiligung von mindestens einem Fluoratom ein. Hydrocarbon which is substituted by various halogen atoms having at least one fluorine atom, wherein all other optional halogen atoms are selected from the group fluorine, chlorine or bromine, iodine. The corresponding halogen atoms may be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain. Partially fluorinated haloalkyl also includes the complete substitution of halogen with the participation of at least one fluorine atom of the straight-chain or branched chain.

„Haloalkoxy" ist z.B. OCF3, OCHF2, OCH2F, OCF2CF3, OCH2CF3 und 0CH2CH2C1; Entsprechendes gilt für Haloalkenyl und andere durch Halogen substituierten Reste. "Haloalkoxy" is, for example, OCF 3 , OCHF 2 , OCH 2 F, OCF 2 CF 3 , OCH 2 CF 3 and OCH 2 CH 2 Cl, and the same applies to haloalkenyl and other radicals substituted by halogen.

Der hier beispielhaft genannte Ausdruck "(Ci-C4)-Alkyl" bedeutet eine Kurzschreibweise für geradkettiges oder verzweigtes Alkyl mit einem bis 4 Kohlenstoffatomen entsprechend der The term "(C 1 -C 4) -alkyl" given here by way of example denotes a short notation for straight-chain or branched alkyl having one to four carbon atoms corresponding to the formula

Bereichsangabe für C-Atome, d. h. umfasst die Reste Methyl, Ethyl, 1 -Propyl, 2-Propyl, 1 -Butyl, 2-Butyl, 2-Methylpropyl oder tert-Butyl. Allgemeine Alkylreste mit einem größeren angegebenen Bereich von C-Atomen, z. B. "(Ci-C6)-Alkyl", umfassen entsprechend auch geradkettige oder verzweigte Alkylreste mit einer größeren Zahl von C-Atomen, d. h. gemäß Beispiel auch die Alkylreste mit 5 und 6 C-Atomen. Wenn nicht speziell angegeben, sind bei den Kohlenwasserstoffresten wie Alkyl-, Alkenyl- und Alkinylresten, auch in zusammengesetzten Resten, die niederen Kohlenstoffgerüste, z.B. mit 1 bis 6 C-Atomen bzw. bei ungesättigten Gruppen mit 2 bis 6 C-Atomen, bevorzugt. Alkylreste, auch in den zusammengesetzten Resten wie Alkoxy, Haloalkyl usw., bedeuten z.B. Methyl, Ethyl, n- oder i-Propyl, n-, i-, t- oder 2-Butyl, Pentyle, Hexyle, wie n-Hexyl, i-Hexyl und 1,3-Dimethylbutyl, Heptyle, wie n-Heptyl, 1 -Methylhexyl und 1 ,4-Dimethylpentyl; Alkenyl- und Alkinylreste haben die Bedeutung der den Alkylresten entsprechenden möglichen ungesättigten Reste, wobei mindestens eine Doppelbindung bzw. Dreifachbindung enthalten ist. Bevorzugt sind Reste mit einer Doppelbindung bzw. Range for C atoms, ie, includes the radicals methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl or tert-butyl. General alkyl radicals having a larger specified range of carbon atoms, eg. B. "(Ci-C6) -alkyl", accordingly also include straight-chain or branched alkyl radicals having a larger number of carbon atoms, ie according to Example, the alkyl radicals having 5 and 6 carbon atoms. Unless specifically stated, in the hydrocarbon radicals such as alkyl, alkenyl and alkynyl, even in composite radicals, the lower carbon skeletons, for example having 1 to 6 carbon atoms or in unsaturated groups having 2 to 6 carbon atoms, are preferred. Alkyl radicals, including in the assembled radicals such as alkoxy, haloalkyl, etc., mean, for example, methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls, such as n-hexyl, i Hexyl and 1,3-dimethylbutyl, heptyls such as n-heptyl, 1-methylhexyl and 1, 4-dimethylpentyl; Alkenyl and alkynyl radicals have the meaning of the possible unsaturated radicals corresponding to the alkyl radicals, wherein at least one double bond or triple bond is contained. Preference is given to radicals having a double bond or

Dreifachbindung. Triple bond.

Der Begriff„Alkenyl" schließt insbesondere auch geradkettige oder verzweigte offenkettige The term "alkenyl" in particular also includes straight-chain or branched open-chain

Kohlenwasserstoffreste mit mehr als einer Doppelbindung ein, wie 1,3-Butadienyl und 1 ,4-Pentadienyl, aber auch Allenyl- oder Kumulenyl-reste mit einer bzw. mehreren kumulierten Doppelbindungen, wie beispielsweise Allenyl (1,2-Propadienyl), 1 ,2-Butadienyl und 1,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z B. (aber nicht beschränkt auf) (C2-C6)- Alkenyl wie Ethenyl, 1-Propenyl, 2-Propenyl, 1 -Methylethenyl, 1 -Butenyl, 2-Butenyl, 3- Butenyl, 1 -Methyl- 1-propenyl, 2-Methyl-l-propenyl, 1 -Methyl-2-propenyl, 2-Methyl-2-propenyl, 1- Pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1 -Methyl- 1 -butenyl, 2-Methyl-l -butenyl, 3 -Methyl- 1- butenyl, 1 -Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, l-Methyl-3 -butenyl, 2-Methyl-3- butenyl, 3 -Methyl-3 -butenyl, 1 , 1 -Dimethyl-2-propenyl, 1 ,2-Dimethyl- 1 -propenyl, 1 ,2-Dimethyl-2- propenyl, 1 -Ethyl- 1-propenyl, 1 -Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- Hexenyl, 1 -Methyl- 1-pentenyl, 2-Methyl-l -pentenyl, 3-Methyl-l-pentenyl, 4-Methyl-l-pentenyl, 1- Methyl-2-pentenyl, 2-Methyl-2-pentenyl, 3-Methyl-2-pentenyl, 4-Methyl-2-pentenyl, l-Methyl-3- pentenyl, 2-Methyl-3 -pentenyl, 3 -Methyl-3 -pentenyl, 4-Methyl-3 -pentenyl, 1 -Methyl-4-pentenyl, 2- Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1 , 1 -Dimethyl-2-butenyl, 1 , 1 -Dimethyl- 3 -butenyl, 1 ,2-Dimethyl- 1 -butenyl, 1 ,2-Dimethyl-2-butenyl, 1 ,2-Dimethyl-3 -butenyl, 1,3-Dimethyl-l- butenyl, l,3-Dimethyl-2-butenyl, l,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3 -butenyl, 2,3-Dimethyl-l- butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-l -butenyl, 3,3-Dimethyl-2- butenyl, 1-Ethyl-l-butenyl, l-Ethyl-2 -butenyl, 1 -Ethyl- 3 -butenyl, 2-Ethyl-l-butenyl, 2-Ethyl-2-butenyl, 2-Ethyl-3 -butenyl, 1 , 1 ,2-Trimethyl-2-propenyl, 1 -Ethyl- 1 -methyl-2-propenyl, 1 -Ethyl-2-methyl- 1 - propenyl und 1 -Ethyl-2-methyl-2-propenyl. Hydrocarbon radicals having more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, but also allenyl or cumulenyl radicals having one or more cumulated double bonds, such as allenyl (1,2-propadienyl), 1, 2-butadienyl and 1,2,3-pentatrienyl. Alkenyl is, for example, vinyl, which may optionally be substituted by further alkyl radicals, for example (but not limited to) (C 2 -C 6) alkenyl, such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl , 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3 Pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl -2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1, 1-dimethyl-2-propenyl, 1, 2-dimethyl-1-propenyl, 1 , 2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1 pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl , 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentene 1, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1, 1-dimethyl-2-butenyl, 1, 1-dimethyl 3 -butenyl, 1, 2-dimethyl-1-butenyl, 1, 2-dimethyl-2-butenyl, 1, 2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl 2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl 3-butenyl, 3,3-dimethyl-1-butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2- Ethyl 1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1, 1, 2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl 2-methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl.

Der Begriff„Alkinyl" schließt insbesondere auch geradkettige oder verzweigte offenkettige The term "alkynyl" in particular also includes straight-chain or branched open-chain

Kohlenwasserstoffreste mit mehr als einer Dreifachbindung oder auch mit einer oder mehreren Hydrocarbon radicals with more than one triple bond or with one or more

Dreifachbindungen und einer oder mehreren Doppelbindungen ein, wie beispielsweise 1,3-Butatrienyl bzw. 3-Penten-l -in-l -yl. (C2-C6)-Alkinyl bedeutet z.B. Ethinyl, 1-Propinyl, 2-Propinyl, 1-Butinyl, 2- Butinyl, 3-Butinyl, 1 -Methyl-2-propinyl, 1 -Pentinyl, 2-Pentinyl, 3-Pentinyl, 4-Pentinyl, l -Methyl-2- butinyl, l -Methyl-3 -butinyl, 2-Methyl-3 -butinyl, 3 -Methyl- 1 -butinyl, 1 , 1 -Dimethyl-2-propinyl, 1 -Ethyl-Triple bonds and one or more double bonds, such as 1,3-butatrienyl and 3-penten-1-yn-1-yl, respectively. (C 2 -C 6) -alkynyl denotes, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2 Butinyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl 3 -butynyl, 3-methyl-1-butinyl, 1, 1-dimethyl-2-propynyl, 1-ethyl

2- propinyl, 1 -Hexinyl, 2-Hexinyl, 3-Hexinyl, 4-Hexinyl, 5-Hexinyl, 1 -Methyl-2-pentinyl, l -Methyl-3- pentinyl, 1 -Methyl-4-pentinyl, 2-Methyl-3-pentinyl, 2-Methyl-4-pentinyl, 3 -Methyl- 1 -pentinyl, 3- Methyl-4-pentinyl, 4-Methyl- 1 -pentinyl, 4-Methyl-2-pentinyl, 1 , 1 -Di-methyl-2-butinyl, 1 , 1 -Dimethyl-3 - butinyl, 1 ,2-Dimethyl-3 -butinyl, 2,2-Dimethyl-3 -butinyl, 3,3-Dimethyl-l -butinyl, 1 -Ethyl-2-butinyl, 1 - Ethyl-3 -butinyl, 2-Ethyl-3 -butinyl und 1 -Ethyl- 1 -methyl-2-propinyl. 2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2- Methyl 3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1, 1 - Di-methyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1 - Ethyl 2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl.

Der Begriff„Cycloalkyl" bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl, das gegebenenfalls weiter substituiert ist, bevorzugt durch Wasserstoff, Alkyl, Alkoxy, Cyano, Nitro, Alkylthio, Haloalkylthio, Halogen, Alkenyl, Alkinyl, Haloalkyl, AMino, Alkylamino, Bisalkylamino, Alkocycarbonyl, The term "cycloalkyl" means a carbocyclic, saturated ring system preferably having 3-8 ring C atoms, eg cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, which is optionally further substituted, preferably by hydrogen, alkyl, alkoxy, cyano, nitro, alkylthio , Haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alkocycarbonyl,

Hydroxycarbonyl, Arylalkoxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl,

Cycloalkylaminocarbonyl. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden cyclische Systeme mit Substituenten umfasst, wobei auch Substituenten mit einer Doppelbindung am Cycloalkylaminocarbonyl. In the case of optionally substituted cycloalkyl cyclic systems are included with substituents, wherein substituents having a double bond on

Cycloalkylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkyl werden auch mehrcyclische aliphatische Systeme umfasst, wie beispielsweise Bicyclo[l .1.0]butan-l -yl, Bicyclo[l .1.0]butan-2-yl, Bicyclo[2.1.0]pentan-l -yl, Bicyclo[l .1.1 ]pentan-l - yl, Bicyclo[2.1.0]pentan-2-yl, Bicyclo[2.1.0]pentan-5-yl, Bicyclo[2.1.1 ]hexyl, Bicyclo[2.2.1 ]hept-2-yl, Bicyclo[2.2.2]octan-2-yl, Bicyclo[3.2.1 ]octan-2-yl, Bicyclo[3.2.2]nonan-2-yl, Adamantan-l -yl und Cycloalkyl, z. As an alkylidene group such as methylidene, are included. In the case of optionally substituted cycloalkyl, polycyclic aliphatic systems are also included, such as, for example, bicyclo [1,1.0] butan-1-yl, bicyclo [1,1-0] butan-2-yl, bicyclo [2.1.0] pentan-1-yl , Bicyclo [1,11] pentan-1-yl, bicyclo [2.1.0] pentan-2-yl, bicyclo [2.1.0] pentan-5-yl, bicyclo [2.1.1] hexyl, bicyclo [2.2.1 ] hept-2-yl, bicyclo [2.2.2] octan-2-yl, bicyclo [3.2.1] octan-2-yl, bicyclo [3.2.2] nonan-2-yl, adamantane-1-yl and

Adamantan-2-yl, aber auch Systeme wie z. B. l ,l '-Bi(cyclopropyl)-l -yl, l , l '-Bi(cyclopropyl)-2-yl. Der Ausdruck "(C3-Cv)-Cycloalkyl" bedeutet eine Kurzschreibweise für Cycloalkyl mit drei bis 7 Adamantan-2-yl, but also systems such. B. l, l '-Bi (cyclopropyl) -1-yl, l, l' -Bi (cyclopropyl) -2-yl. The term "(C3-Cv) cycloalkyl" means a shorthand notation for cycloalkyl of three to seven

Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome. Im Falle von substituiertem Cycloalkyl werden auch spirocyclische aliphatische Systeme umfasst, wie beispielsweise Spiro[2.2]pent-l -yl, Spiro[2.3]hex-l -yl, Spiro[2.3]hex-4-yl, 3-Spiro[2.3]hex-5-yl, Spiro[3.3]hept-l -yl, Spiro[3.3]hept-2-yl. Carbon atoms corresponding to the range for C atoms. In the case of substituted cycloalkyl, spirocyclic aliphatic systems are also included, such as spiro [2.2] pent-1-yl, spiro [2.3] hex-1-yl, spiro [2.3] hex-4-yl, 3-spiro [2.3] hex-5-yl, spiro [3.3] hept-1-yl, spiro [3.3] hept-2-yl.

„Cycloalkenyl" bedeutet ein carbocyclisches, nicht aromatisches, partiell ungesättigtes Ringsystem mit vorzugsweise 4-8 C-Atomen, z.B. 1 -Cyclobutenyl, 2-Cyclobutenyl, 1 -Cyclopentenyl, 2-Cyclopentenyl,"Cycloalkenyl" means a carbocyclic, non-aromatic, partially unsaturated ring system preferably having 4-8 C atoms, for example 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl,

3- Cyclopentenyl, oder 1 -Cyclohexenyl, 2-Cyclohexenyl, 3-Cyclohexenyl, 1 ,3-Cyclohexadienyl oder 1 ,4-Cyclohexadienyl, wobei auch Substituenten mit einer Doppelbindung am Cycloalkenylrest, z. B. eine Alkylidengruppe wie Methyliden, umfasst sind. Im Falle von gegebenenfalls substituiertem Cycloalkenyl gelten die Erläuterungen für substituiertes Cycloalkyl entsprechend. 3-cyclopentenyl, or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1, 3-cyclohexadienyl or 1, 4-cyclohexadienyl, wherein also substituents having a double bond on the cycloalkenyl radical, for. As an alkylidene group such as methylidene, are included. In the case of optionally substituted cycloalkenyl, the explanations for substituted cycloalkyl apply correspondingly.

Der Begriff„Alkyliden", z. B. auch in der Form (Ci-Cio)-Alkyliden, bedeutet den Rest eines geradkettigen oder verzweigten offenkettigen Kohlenwasserstoffrests, der über eine Zweifachbindung gebunden ist. Als Bindungsstelle für Alkyliden kommen naturgemäß nur Positionen am Grundkörper in Frage, an denen zwei H- Atome durch die Doppelbindung ersetzt werden können; Reste sind z. B. =CH2, =CH-CH3, =C(CH3)-CH3, =C(CH3)-C2H5 oder =C(C2H5)-C2H5. Cycloalkyliden bedeutet ein The term "alkylidene", for example also in the form (C 1 -C 10) -alkylidene, means the radical of a straight-chain or branched open-chain hydrocarbon radical which has a double bond is bound. As a binding site for alkylidene naturally only positions on the body in question, in which two H atoms can be replaced by the double bond; Remains are z. B. = CH 2, = CH-CH 3, = C (CH 3) -CH 3, = C (CH 3) -C 2 H 5 or = C (C 2 H 5) C 2 H5. Cycloalkylidene means a

carbocyclischer Rest, der über eine Zweifachbindung gebunden ist. carbocyclic radical bonded via a double bond.

„Alkoxyalkyl" steht für einen über eine Alkylgruppe gebundenen Alkoxyrest und„Alkoxyalkoxy" bedeutet einen über ein Sauerstoffatom gebundenen Alkoxyalkylrest, z.B. (aber nicht beschränkt auf) Methoxymethoxy, Methoxyethoxy, Ethoxyethoxy, Methoxy-n-propyloxy. "Alkoxyalkyl" means an alkoxy group attached via an alkyl group, and "alkoxyalkoxy" means an alkoxyalkyl group bonded via an oxygen atom, e.g. (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy.

„Alkylthioalkyl" steht für einen über eine Alkylgruppe gebundenen Alkylthiorest und "Alkylthioalkyl" means an alkylthio radical bonded via an alkyl group and

„Alkylthioalkylthio" bedeutet einen über ein Sauerstoffatom gebundenen Alkylthioalkylrest. "Alkylthioalkylthio" means an alkylthioalkyl radical bonded via an oxygen atom.

„Arylalkoxyalkyl" steht für einen über eine Alkylgruppe gebundenen Aryloxyrest und "Arylalkoxyalkyl" stands for an aryloxy radical bound via an alkyl group and

„Heteroaryloxyalkyl" bedeutet einen über eine Alkylgruppe gebundenen Heteroaryloxyrest. "Heteroaryloxyalkyl" means a heteroaryloxy group bonded via an alkyl group.

„Haloalkoxyalkyl" steht für einen gebundenen Haloalkoxyrest und„Haloalkylthioalkyl" bedeutet einen über eine Alkylgruppe gebundenen Haloalkylthiorest. „Arylalkyl" steht für einen über eine Alkylgruppe gebundenen Arylrest,„Heteroarylalkyl" bedeutet einen über eine Alkylgruppe gebundenen Heteroarylrest, und„Heterocyclylalkyl" bedeutet einen über eine Alkylgruppe gebundenen Heterocyclylrest. "Haloalkoxyalkyl" means a haloalkoxy radical attached and "haloalkylthioalkyl" means a haloalkylthio radical attached via an alkyl group. "Arylalkyl" means an aryl group attached via an alkyl group, "heteroarylalkyl" means a heteroaryl group bonded via an alkyl group, and "heterocyclylalkyl" means a heterocyclyl group bonded through an alkyl group.

„Cycloalkylalkyl" steht für einen über eine Alkylgruppe gebundenen Cycloalkylrest, z. B. (aber nicht beschränkt auf) Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, 1 - Cyclopropyleth-l -yl, 2-Cyclopropyleth-l -yl, 1 -Cyclopropylprop-l -yl, 3-Cyclopropylprop-l -yl. "Cycloalkylalkyl" means a cycloalkyl radical attached via an alkyl group, for example (but not limited to) cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-cyclopropyleth-1-yl, 2-cyclopropyleth-1-yl, 1-cyclopropylpropyl l -yl, 3-cyclopropylprop-1-yl.

Erfindungsgemäß steht "Haloalkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Halogenalkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie (Ci-Cs)-, (CI-CÖ)- oder (Ci-C4)-Haloalkylthio, z.B. (aber nicht beschränkt auf) Trifluormethylthio, Pentafluorethylthio, Difluormethyl, 2,2-Difluoreth-l -ylthio, 2,2,2-Difluoreth-l - ylthio, 3,3,3-prop-l -ylthio. According to the invention, "haloalkylthio" - alone or as part of a chemical group - represents straight-chain or branched S-haloalkyl, preferably having 1 to 8, or having 1 to 6 carbon atoms, such as (C 1 -C 5) -, (C 1 -C 5) - or (C 1 -C 4) -haloalkylthio, for example (but not limited to) trifluoromethylthio, pentafluoroethylthio, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio.

„Halocycloalkyl" und„Halocycloalkenyl" bedeuten durch gleiche oder verschiedene Halogenatome, wie z. B. F, Cl und Br, oder durch Haloalkyl, wie z. B. Trifluormethyl oder Difluormethyl teilweise oder vollständig substituiertes Cycloalkyl oder Cycloalkenyl , z.B. 1 -Fluorcycloprop-l -yl, 2-Fluorcycloprop- 1 -yl, 2,2-Difluorcycloprop-l -yl, 1 -Fluorcyclobut-l -yl, 1 -Trifluormethylcycloprop-l -yl, 2- Trifluormethylcycloprop- 1 -yl, 1 -Chlor-cycloprop- 1 -yl, 2-Chlorcycloprop- 1 -yl, 2,2-Dichlorcycloprop- 1 - yl, 3,3-Difluorcyclobutyl, "Halocycloalkyl" and "Halocycloalkenyl" mean by the same or different halogen atoms, such as. B. F, Cl and Br, or by haloalkyl, such as. B. trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, for example 1-fluorocycloprop-l -yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobutyl-1, Trifluoromethylcycloprop-1-yl, 2 Trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl,

Erfindungsgemäß steht "Trialkylsilyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Si-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 According to the invention "trialkylsilyl" - alone or as part of a chemical group - is straight-chain or branched Si-alkyl, preferably with 1 to 8, or with 1 to 6

Kohlenstoffatomen, wie Tri-[(Ci-Cg)-, (Ci-Ce)- oder (Ci-C4)-alkyl]silyl, z.B. (aber nicht beschränkt auf) Trimethylsilyl, Triethylsilyl, Tri-(n-propyl)silyl, Tri-(iso-propyl)silyl, Tri-(n-butyl)silyl, Tri-(1 - methylprop-l -yl)silyl, Tri-(2-methylprop-l -yl)silyl, Tri(l ,l -Dimethyleth-l -yl)silyl, Tri(2,2- Dimethyleth- 1 -yl)silyl.  Carbon atoms such as tri - [(Ci-Cg) -, (Ci-Ce) - or (Ci-C4) -alkyl] silyl, e.g. (but not limited to) trimethylsilyl, triethylsilyl, tri (n-propyl) silyl, tri (iso-propyl) silyl, tri (n-butyl) silyl, tri (1-methylprop-1-yl) silyl, Tri- (2-methylprop-1-yl) silyl, tri (1,1-dimethyleth-1-yl) silyl, tri (2,2-dimethyl-1-yl) silyl.

Wenn die Verbindungen durch Wasserstoffverschiebung Tautomere bilden können, welche strukturell formal nicht durch die allgemeine Formel (I) erfasst würden, so sind diese Tautomere gleichwohl von der Definition der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) umfasst, sofern nicht ein bestimmtes Tautomer Gegenstand der Betrachtung ist. So können beispielsweise viele If the compounds can form tautomers by hydrogen shift which would not be structurally formally recognized by the general formula (I), these tautomers are nevertheless encompassed by the definition of the compounds of the general formula (I) according to the invention, unless a particular tautomer is the subject of consideration is. For example, many

Carbonylverbindungen sowohl in der Ketoform wie auch in der Enolform vorliegen, wobei beide Formen durch die Definition der Verbindung der allgemeinen Formel (I) umfasst werden.  Carbonyl compounds in both the keto form as well as in the enol form, both forms by the definition of the compound of general formula (I) are included.

Die Verbindungen der allgemeinen Formel (I) können je nach Art und Verknüpfung der Substituenten als Stereoisomere vorliegen. Die durch ihre spezifische Raumform definierten möglichen Stereoisomere, wie Enantiomere, Diastereomere, Z- und E-Isomere sind alle von der allgemeinen Formel (I) umfasst. Sind beispielsweise eine oder mehrere Alkenylgruppen vorhanden, so können Diastereomere (Z- und E- Isomere) auftreten. Sind beispielsweise ein oder mehrere asymmetrische Kohlenstoffatome vorhanden, so können Enantiomere und Diastereomere auftreten. Stereoisomere lassen sich aus den bei der Depending on the nature and linkage of the substituents, the compounds of the general formula (I) can exist as stereoisomers. The possible stereoisomers defined by their specific spatial form, such as enantiomers, diastereomers, Z and E isomers, are all encompassed by the general formula (I). If, for example, one or more alkenyl groups are present, diastereomers (Z and E isomers) can occur. For example, if one or more asymmetric carbon atoms are present, enantiomers and diastereomers may occur. Stereoisomers can be distinguished from those in the

Herstellung anfallenden Gemischen nach üblichen Trennmethoden erhalten. Die chromatographische Trennung kann sowohl im analytischen Maßstab zur Feststellung des Enantiomerenüberschusses bzw. des Diastereomerenüberschusses, wie auch im präparativen Maßstab zur Herstellung von Prüfmustern für die biologische Ausprüfung erfolgen. Ebenso können Stereoisomere durch Einsatz stereoselektiver Reaktionen unter Verwendung optisch aktiver Ausgangs- und/oder Hilfsstoffe selektiv hergestellt werden. Die Erfindung betrifft somit auch alle Stereoisomeren, die von der allgemeinen Formel (I) umfasst, jedoch nicht mit ihrer spezifischen Stereoform angegeben sind, sowie deren Gemische. Preparation of resulting mixtures obtained by conventional separation methods. The chromatographic separation can be carried out both on an analytical scale to determine the enantiomeric excess or the diastereomeric excess, as well as on a preparative scale for the preparation of test samples for the biological assay. Similarly, stereoisomers can be selectively prepared by using stereoselective reactions using optically active sources and / or adjuvants. The invention thus also relates to all stereoisomers which comprises the general formula (I) but are not specified with their specific stereoform, and mixtures thereof.

Sofern die Verbindungen als Feststoffe erhalten werden, kann die Reinigung auch durch If the compounds are obtained as solids, the purification can also by

Umkristallisieren oder Digerieren erfolgen. Sofern einzelne Verbindungen (I) nicht auf den nachstehend beschriebenen Wegen zufriedenstellend zugänglich sind, können sie durch Derivatisierung anderer Verbindungen (I) hergestellt werden. Als Isolierungs-, Reinigungs- und Stereoisomerenauftrennungsverfahren von Verbindungen der allgemeinen Formel (I) kommen Methoden in Frage, die dem Fachmann aus analogen Fällen allgemein bekannt sind, z.B. durch physikalische Verfahren wie Kristallisation, Chromatographieverfahren, vor allem Säulenchromatographie und HPLC (Hochdruckflüssigchromatographie), Destillation, gegebenenfalls unter reduziertem Druck, Extraktion und andere Verfahren, können gegebenfalls verbleibende Gemische in der Regel durch chromatographische Trennung, z.B. an chiralen Festphasen, getrennt werden. Für präparative Mengen oder im industriellen Maßstab kommen Verfahren in Frage wie Kristallisation, z.B. diastereomerer Salze, die aus den Diastereomerengemischen mit optisch aktiven Säuren und gegebenenfalls bei vorhandenen sauren Gruppen mit optisch aktiven Basen erhalten werden können. Recrystallize or digest. Unless individual compounds (I) are satisfactorily accessible by the routes described below, they can be prepared by derivatization of other compounds (I). Suitable isolation, purification and stereoisomer separation methods of compounds of the general formula (I) are methods which are generally known to the person skilled in the art from analogous cases, for example by physical methods such as crystallization, chromatography methods, especially column chromatography and HPLC (high pressure liquid chromatography), distillation , optionally under reduced pressure, extraction and other methods, any remaining mixtures can be separated, as a rule, by chromatographic separation, for example on chiral solid phases. Suitable for preparative amounts or on an industrial scale are processes such as crystallization, for example diastereomeric salts, which can be obtained from the diastereomer mixtures with optically active acids and optionally in the presence of acidic groups having optically active bases.

Synthese von substituierten Pyrazole der allgemeinen Formel (I) Synthesis of substituted pyrazoles of the general formula (I)

Figure imgf000045_0001
Figure imgf000045_0001

Die erfindungsgemäßen substituierten Pyrazole der allgemeinen Formel (I) können ausgehend von bekannten Verfahren hergestellt werden. Die eingesetzten und untersuchten Syntheserouten gehen dabei von kommerziell erhältlichen oder leicht herstellbaren Aminen, von entsprechend substituierten Aldehyden und von kommerziell erhältlichen Chemikalien wie Malonsäurederivaten und Nitromethan aus. Die Gruppierungen Q, Y, W, R1, R2, R3, R4 und R5 der allgemeinen Formel (I) haben in den nachfolgenden Schemata die zuvor definierten Bedeutungen, sofern nicht beispielhafte, aber nicht einschränkende, Definitionen erfolgen. The substituted pyrazoles of the general formula (I) according to the invention can be prepared starting from known processes. The synthetic routes used and investigated are based on commercially available or easily prepared amines, on appropriately substituted aldehydes and on commercially available chemicals such as malonic acid derivatives and nitromethane. The groupings Q, Y, W, R 1 , R 2 , R 3 , R 4 and R 5 of the general formula (I) have the meanings defined above in the following schemes, unless exemplary but non-limiting definitions take place.

Die Synthese der erfindungsgemäßen Verbindungen der allgemeinen Formel (Ia) erfolgt über eine Amidkupplung von einer Säure der allgemeinen Formel (II) mit einem Amin der allgemeinen Formel (III) in Gegenwart eines Amidkupplungsreagenzes wie zum Beispiel T3P, Dicyclohexylcarbodiimid, N- (3-Dimethylaminopropyl)-N'-ethylcarbodiimid, N,N'-Cabonyldiimidazol, 2-Chlor-l,3-dimethyl- imidazolium chlorid oder 2-Chlor-l-methylpyridinium iodid (siehe Chemistry of Peptide Synthsis, Ed. N. Leo Benoiton, Taylor & Francis, 2006, ISBN- 10: 1-57444-454-9). Polymergebundene Reagenzien wie zum Beispiel polymergebundenes Dicyclohexylcarbodiimid sind auch für diese Kupplungs-reaktion geeignet. Die Reaktion findet bevorzugt in dem Temperaturbereich zwischen 0 °C und 80 °C, in einem adäquaten Lösungsmittel wie zum Beispiel Dichlormethan, Acetonitril, NN-Dimethyl-formamid oder Ethylacetat und in Gegenwart eine Base wie zum Beispiel Triethylamin, N,N-Diisopropylethylamin oder l,8-Diazabicyclo[5.4.0]undec-7-cen statt (siehe Schema 1). Für die T3P Peptidkupplungsbedingungen siehe Organic Process Research & Develo ment 2009, 13, 900-906. The synthesis of the compounds of the general formula (Ia) according to the invention is carried out via an amide coupling of an acid of the general formula (II) with an amine of the general formula (III) in the presence of an amide coupling reagent such as T3P, dicyclohexylcarbodiimide, N- (3-dimethylaminopropyl ) -N '-ethylcarbodiimid, N, N' -Cabonyldiimidazol, 2-chloro-l, 3-dimethyl-imidazolium chloride or 2-chloro-l-methylpyridinium iodide (see Chemistry of peptide Synthsis, Ed. N. Leo Benoiton, Taylor & Francis, 2006, ISBN 10: 1-57444-454-9). Polymer-bound reagents such as polymer-bound dicyclohexylcarbodiimide are also suitable for this coupling reaction. The reaction preferably takes place in the temperature range between 0 ° C and 80 ° C, in an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate and in the presence of a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1). For the T3P peptide coupling conditions, see Organic Process Research & Develo ment 2009, 13, 900-906.

Figure imgf000046_0001
Figure imgf000046_0001

(la) Schema 1  (la) Scheme 1

Die Synthese der Säure der allgemeinen Formel (II) lässt sich durch Verseifung der Verbindung der allgemeinen Formel (IV) nach oder analog dem Fachmann bekannten Methoden herstellen. The synthesis of the acid of the general formula (II) can be prepared by saponification of the compound of the general formula (IV) according to or analogously to methods known to those skilled in the art.

Die Verseifung lässt sich in Gegenwart einer Base oder einer Lewis-Säure durchführen. Die Base kann ein Hydroxid-Salz von einem Alkali-Metall (wie zum Beispiel Lithium, Natrium oder Kalium) sein, und die Verseifungsreaktion findet bevorzugt in dem Temperaturbereich zwischen Raumtemperatur und 100 °C statt. Die Lewis-Säure kann Bortribromid sein, und die Reaktion in einem Temperaturbereich zwischen -20 °C und 100 °C, vorzu sweise -5 °C und 50 °C durchgeführt werden. The saponification can be carried out in the presence of a base or a Lewis acid. The base may be a hydroxide salt of an alkali metal (such as lithium, sodium or potassium), and the saponification reaction preferably takes place in the temperature range between room temperature and 100 ° C. The Lewis acid may be boron tribromide and the reaction carried out in a temperature range between -20 ° C and 100 ° C, preferably -5 ° C and 50 ° C.

Figure imgf000046_0002
Figure imgf000046_0002

(IV)  (IV)

Mit R' = (Ci-C4)-Alkyl. With R '= (C 1 -C 4 ) -alkyl.

Schema 2 Scheme 2

Die Synthese der Verbindung der allgemeinen Formel (IV) lässt sich durch Alkylierung der Verbindung der allgemeinen Formel (V) mit einem Halogenid der allgemeinen Formel (VI) in Gegenwart einer Base nach oder analog dem Fachmann bekannten Methoden herstellen (siehe Schema 3). Die Base kann ein Carbonat-Salz von einem Alkali-Metall (wie zum Beispiel Lithium, Natrium, Kalium oder Caesium) sein, und die Verseifungsreaktion findet bevorzugt in dem Temperaturbereich zwischen The synthesis of the compound of the general formula (IV) can be prepared by alkylating the compound of the general formula (V) with a halide of the general formula (VI) in the presence of a base or by methods analogous to those skilled in the art (see Scheme 3). The base can be Carbonate salt of an alkali metal (such as lithium, sodium, potassium or cesium), and the saponification reaction preferably occurs in the temperature range

Raumtemperatur und 150 °C in einem adäquaten Lösungsmittel wie zum Beispiel Dichlormethan, Acetonitril, NN-Dimethylformamid oder Ethylacetat statt. Siehe J. Med. Chem. 2011, 54(16), 5820- 5835 und WO2010/010154. Room temperature and 150 ° C in an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate instead. See J. Med. Chem. 2011, 54 (16), 5820-5835 and WO2010 / 010154.

Figure imgf000047_0001
Figure imgf000047_0001

Mit R' = (Ci-C4)-Alkyl. With R '= (C 1 -C 4 ) -alkyl.

Mit X = Halogen. With X = halogen.

Schema 3 Scheme 3

In Schema 4 wird die Synthese der Verbindung der allgemeinen Formel (V) durch Reaktion eines Enamines der allgemeinen Formel (VII) mit einem Hydrazin der allgemeinen Formel (VIII) in einem adäquaten Lösungsmittel wie zum Beispiel Methanol oder Ethanol beschrieben. Alternativ kann man die Reaktion in einem Lösungsmittel wie zum Beispiel Tetrahydrofuran durchführen. Siehe Scheme 4 describes the synthesis of the compound of general formula (V) by reaction of an enamine of general formula (VII) with a hydrazine of general formula (VIII) in an adequate solvent such as methanol or ethanol. Alternatively, the reaction may be carried out in a solvent such as tetrahydrofuran. Please refer

WO2013/178591 und US2007/0049603. WO2013 / 178591 and US2007 / 0049603.

Figure imgf000047_0002
Figure imgf000047_0002

(viii) (V)  (viii) (V)

Schema 4 Scheme 4

Die Verbindungen der allgemeinen Formel (VII) lassen sich durch Kondensation eines Ketons der allgemeinen Formel (IX) und Dimethylformamiddimethylacetal der allgemeinen Formel (X) herstellen (siehe Schema 5; Tetrahedron 1998, 54(20), 5075-5088). The compounds of the general formula (VII) can be prepared by condensation of a ketone of the general formula (IX) and dimethylformamide dimethyl acetal of the general formula (X) (see Scheme 5, Tetrahedron 1998, 54 (20), 5075-5088).

Figure imgf000047_0003
Schema 5.
Figure imgf000047_0003
Scheme 5.

In Schema 6 wird die Synthese der Verbindung der allgemeinen Formel (IX) durch Reaktion eines Nitrils der allgemeinen Formel (XI) mit einem Grignard-Reagenz der allgemeinen Formel (XII) in in einem adäquaten Lösungsmittel wie zum Beispiel Tetrahydrofuran, durchführen. Die Reaktion findet bevorzugt in dem Temperaturbereich zwischen -100 °C und 100 °C statt. Siehe US2014/0194443 und Synthesis 2009, 9, 1494-1498.

Figure imgf000048_0001
In Scheme 6, the synthesis of the compound of general formula (IX) is carried out by reaction of a nitrile of general formula (XI) with a Grignard reagent of general formula (XII) in an adequate solvent such as tetrahydrofuran. The reaction preferably takes place in the temperature range between -100 ° C and 100 ° C. See US2014 / 0194443 and Synthesis 2009, 9, 1494-1498.
Figure imgf000048_0001

(χ|) (χ| (ix)( χ |) (χ | (ix)

Mit X = Halogen. With X = halogen.

Schema 6. Alternativ lassen sich Verbindungen der allgemeinen Formel (Ia) durch Reaktion eines Scheme 6. Alternatively, compounds of the general formula (Ia) can be obtained by reaction of a

Säurehalogenides der allgemeinen Formel (XIII) und einem Amin der allgemeinen Formel (III) in Gegenwart einer Base wie zum Beispiel Triethylamin, in einem adäquaten Lösungsmittel wie zum Beispiel Dichlormethan herstellen (siehe Schema 7). Die Reaktion wird bevorzugt in dem  Acid halides of general formula (XIII) and an amine of general formula (III) in the presence of a base such as triethylamine, in an adequate solvent such as dichloromethane produce (see Scheme 7). The reaction is preferred in the

Temperaturbereich zwischen -20 °C und 100 °C durchgeführt, vorzugsweise zwischen -5 °C und 50 °C durchgeführt. Temperature range between -20 ° C and 100 ° C carried out, preferably between -5 ° C and 50 ° C.

Figure imgf000048_0002
Figure imgf000048_0002

(XIII) (III) (la) (XIII) (III) (Ia)

Mit X' = Fluor, Chlor und Brom. With X '= fluorine, chlorine and bromine.

Schema 7. Die Verbindungen der allgemeinen Formel (XIII) durch Reaktion der Verbindung der allgemeinen Formel (II) mit einem Thionylhalogenid der allgemeinen Formel (XIV) nach oder analog dem Scheme 7. The compounds of the general formula (XIII) by reaction of the compound of the general formula (II) with a thionyl halide of the general formula (XIV) according to or analogously to

Fachmann bekannten Methoden herstellen siehe Schema 8). To prepare methods known to those skilled in the art, see Scheme 8).

Figure imgf000049_0001
Figure imgf000049_0001

(Ii) (xiv) ( iii) Mit X' = Fluor, Chlor und Brom.  (Ii) (xiv) (iii) With X '= fluorine, chlorine and bromine.

Schema 8. Scheme 8.

Die Verbindungen der allgemeinen Formel (XVI) lassen sich durch Kondensation eines Ketons der allgemeinen Formel (XV) und Dimethylformamiddimethylacetal der allgemeinen Formel (X) herstellen (siehe Schema 9; Tetrahedron 1998, 54(20), 5075-5088). The compounds of the general formula (XVI) can be prepared by condensation of a ketone of the general formula (XV) and dimethylformamide dimethyl acetal of the general formula (X) (see Scheme 9, Tetrahedron 1998, 54 (20), 5075-5088).

Figure imgf000049_0002
Figure imgf000049_0002

Schema 9.  Scheme 9.

In Schema 10 wird die Synthese der Verbindung der allgemeinen Formel (XVII) durch Reaktion eines Enamines der allgemeinen Formel (XVI) mit einem Hydrazin der allgemeinen Formel (VIII) in einem adäquaten Lösungsmittel wie zum Beispiel Methanol oder Ethanol beschrieben. Alternativ kann man die Reaktion in einem Lösungsmittel wie zum Beispiel Tetrahydrofuran durchführen. Siehe Scheme 10 describes the synthesis of the compound of general formula (XVII) by reaction of an enamine of general formula (XVI) with a hydrazine of general formula (VIII) in an adequate solvent such as methanol or ethanol. Alternatively, the reaction may be carried out in a solvent such as tetrahydrofuran. Please refer

WO2013/178591 und US2007/0049603. WO2013 / 178591 and US2007 / 0049603.

Figure imgf000049_0003
Figure imgf000049_0003

(xvi) (viii) (xvii)  (xvi) (viii) (xvii)

Schema 10. In Schema 1 1 wird die Synthese der Verbindung der allgemeinen Formel (XIX) durch Reaktion eines Pyrazoles der allgemeinen Formel (XVII) mit einem Halogensuccinimid der allgemeinen Formel Scheme 10. In Scheme 1 1, the synthesis of the compound of the general formula (XIX) is effected by reaction of a pyrazole of the general formula (XVII) with a halosuccinimide of the general formula

(XVIII) in einem adä uaten Lösungsmittel wie zum Beispiel DMF beschrieben. (XVIII) in an appropriate solvent such as DMF.

Figure imgf000050_0001
Figure imgf000050_0001

(XVII) (XVIII) (XIX) (XVII) (XVIII) (XIX)

Mit X" = Chlor, Brom und Iod. With X "= chlorine, bromine and iodine.

Schema 1 1. Die Synthese der Verbindung der allgemeinen Formel (XX) lässt sich durch Alkylierung der Scheme 1 1. The synthesis of the compound of general formula (XX) can be carried out by alkylation of the

Verbindung der allgemeinen Formel (XIX) mit einem Halogenid der allgemeinen Formel (VI) in Gegenwart einer Base nach oder analog dem Fachmann bekannten Methoden herstellen (siehe Schema 12). Die Base kann ein Carbonat-Salz von einem Alkali-Metall (wie zum Beispiel Lithium, Natrium, Kalium oder Caesium) sein, und die Verseifungsreaktion findet bevorzugt in dem Temperaturbereich zwischen Raumtemperatur und 150 °C in einem adäquaten Lösungsmittel wie zum Beispiel  Compound of the general formula (XIX) with a halide of the general formula (VI) in the presence of a base according to or analogous methods known in the art (see Scheme 12). The base may be a carbonate salt of an alkali metal (such as lithium, sodium, potassium or cesium), and the saponification reaction preferably takes place in the temperature range between room temperature and 150 ° C in an adequate solvent such as, for example

Dichlormethan, Acetonitril, NN-Dimethylformamid oder Ethylacetat statt. Dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate.

Figure imgf000050_0002
Figure imgf000050_0002

(xix) (vi) (XX) (xix) (vi) (XX)

Mit R' = (Ci-C4)-Alkyl. With R '= (C 1 -C 4 ) -alkyl.

Mit X = Halogen. With X = halogen.

Mit X" = Chlor, Brom und Iod. With X "= chlorine, bromine and iodine.

Schema 12 Scheme 12

Die Synthese der Säure der allgemeinen Formel (XXI) lässt sich durch Verseifung der Verbindung der allgemeinen Formel (XX) nach oder analog dem Fachmann bekannten Methoden herstellen. The synthesis of the acid of general formula (XXI) can be prepared by saponification of the compound of general formula (XX) or analogously to methods known to those skilled in the art.

Die Verseifung lässt sich in Gegenwart einer Base oder einer Lewis-Säure durchführen. Die Base kann ein Hydroxid-Salz von einem Alkali-Metall (wie zum Beispiel Lithium, Natrium oder Kalium) sein, und die Verseifungsreaktion findet bevorzugt in dem Temperaturbereich zwischen Raumtemperatur und 100 °C statt. Die Lewis-Säure kann Bortribromid sein, und die Reaktion in einem Temperaturbereich zwischen -20 °C und 100 °C, vorzugsweise -5 °C und 50 °C durchgeführt werden. The saponification can be carried out in the presence of a base or a Lewis acid. The base may be a hydroxide salt of an alkali metal (such as lithium, sodium or potassium), and the saponification reaction preferably takes place in the temperature range between room temperature and 100 ° C. The Lewis acid may be boron tribromide, and the reaction may be carried out in a temperature range between -20 ° C and 100 ° C, preferably -5 ° C and 50 ° C.

Figure imgf000051_0001
Figure imgf000051_0001

(XX) (xxi)  (XX) (xxi)

Mit R' = (Ci-C4)-Alkyl. With R '= (C 1 -C 4 ) -alkyl.

Mit X' ' = Chlor, Brom und Iod.  With X '' = chlorine, bromine and iodine.

Schema 13 Die Synthese der erfindungsgemäßen Verbindungen der allgemeinen Formel (Ib) erfolgt über eineScheme 13 The synthesis of the compounds of general formula (Ib) according to the invention is carried out via a

Amidkupplung von einer Säure der allgemeinen Formel (XXI) mit einem Amin der allgemeinen Formel (III) in Gegenwart eines Amidkupplungsreagenzes wie zum Beispiel T3P, Dicyclohexylcarbodiimid, N- (3-Dimethylaminopropyl)-N'-ethylcarbodiimid, N,N'-Cabonyldiimidazol, 2-Chlor-l,3-dimethyl- imidazolium chlorid oder 2-Chlor-l-methylpyridinium iodid (siehe Chemistry of Peptide Synthsis, Ed. Ν. Leo Benoiton, Taylor & Francis, 2006, ISBN- 10: 1-57444-454-9). Polymergebundene Reagenzien wie zum Beispiel polymergebundenes Dicyclohexylcarbodiimid sind auch für diese Kupplungs-reaktion geeignet. Die Reaktion findet bevorzugt in dem Temperaturbereich zwischen 0 °C und 80 °C, in einem adäquaten Lösungsmittel wie zum Beispiel Dichlormethan, Acetonitril, NN-Dimethyl-formamid oder Ethylacetat und in Gegenwart eine Base wie zum Beispiel Triethylamin, N,N-Diisopropylethylamin oder l,8-Diazabicyclo[5.4.0]undec-7-cen statt (siehe Schema 1). Für die T3P Peptidkupplungsbedingungen siehe Organic Process Research & Development 2009, 13, 900-906. Amide coupling of an acid of general formula (XXI) '-ethylcarbodiimid, N, N' with an amine of general formula (III) in the presence of a Amidkupplungsreagenzes such as T3P, dicyclohexylcarbodiimide, N- (3-dimethylaminopropyl) -N -Cabonyldiimidazol, 2-chloro-1,3-dimethylimidazolium chloride or 2-chloro-1-methylpyridinium iodide (see Chemistry of Peptide Synthsis, Ed., Leo Leo Benoiton, Taylor & Francis, 2006, ISBN 10: 1-57444-454 -9). Polymer-bound reagents such as polymer-bound dicyclohexylcarbodiimide are also suitable for this coupling reaction. The reaction preferably takes place in the temperature range between 0 ° C and 80 ° C, in an adequate solvent such as dichloromethane, acetonitrile, N, N-dimethylformamide or ethyl acetate and in the presence of a base such as triethylamine, N, N-diisopropylethylamine or l, 8-diazabicyclo [5.4.0] undec-7-cene (see Scheme 1). For the T3P peptide coupling conditions, see Organic Process Research & Development 2009, 13, 900-906.

Figure imgf000051_0002
Figure imgf000051_0002

Schema 14 Ausgewählte detaillierte Synthesebeispiele für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) sind im Folgenden aufgeführt. Die angegebenen Beispielnummern entsprechen den in den nachstehenden Tabellen L I bis 1.49 genannten Nummerierungen. Die 'H-NMR-, 13C-NMR- und 19F- NMR-spektroskopischen Daten, die für die in den nachfolgenden Abschnitten beschriebenen chemischen Beispiele angegeben sind, (400 MHz bei 'H-NMR und 150 MHz bei 13C-NMR und 375 MHz bei "F-NMR, Lösungsmittel CDCL, CD3OD oder de-DMSO, interner Standard: Tetramethylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Broker erhalten, und die bezeichneten Signale haben die nachfolgend aufgeführten Bedeutungen: br = breit(es); s = Singulett, d = Dublett, t = Triplett, dd = Doppeldublett, ddd = Dublett eines Doppeldubletts, m = Multiplett, q = Quartett, quint = Quintett, sext = Sextett, sept = Septett, dq = Doppelquartett, dt = Doppeltrip lett. Bei Diastereomerengemischen werden entweder die jeweils signifikanten Signale beider Diastereomere oder das charakteristische Signal des Hauptdiastereomers angegeben. Die verwendeten Abkürzungen für chemische Gruppen haben beispielsweise die nachfolgenden Bedeutungen: Me = CH3, Et = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t- Bu = C(CH3)3, n-Bu = unverzweigtes Butyl, n-Pr = unverzweigtes Propyl, i-Pr = verzweigtes Propyl, c- Pr = Cyclopropyl, c-Hex = Cyclohexyl. Scheme 14 Selected detailed synthesis examples of the compounds of the general formula (I) according to the invention are listed below. The given example numbers correspond to the numbers listed in tables LI to 1.49 below. The 'H-NMR, 13 C-NMR and 19 F-NMR spectroscopic data given for the chemical examples described in the following sections (400 MHz for' H-NMR and 150 MHz for 13 C-NMR and 375 MHz in "F-NMR, solvent CDCL, CD" 3 " OD or de-DMSO, internal standard: tetramethylsilane δ = 0.00 ppm) were obtained with a Broker instrument and the designated signals have the meanings given below: br = broad (it); s = singlet, d = doublet, t = triplet, dd = double doublet, ddd = doublet of double doublet, m = multiplet, q = quartet, quint = quintet, sext = sextet, sept = septet, dq = Double quartet, dt = double-triplet For diastereomeric mixtures, either the respective significant signals of both diastereomers or the characteristic signal of the main diastereomer are given The abbreviations used for chemical groups have the following meanings, for example: Me = CH 3 , Et = CH 2 CH 3 , t -Hex = C (C H 3 ) 2CH (CH 3 ) 2, t -Bu = C (CH 3 ) 3 , n-Bu = unbranched butyl, n-Pr = unbranched propyl, i-Pr = branched propyl, c-Pr = cyclopropyl, c- Hex = cyclohexyl.

Synthesebeispiele: Synthesis Examples:

Synthesebeispiel No. 1.73-101 : Synthesis Example No. 1.73-101:

Synthesestufel : 1 -(2-Chlor-6-fluorphenyl)pro an- 1 -

Figure imgf000052_0001
Synthesis test: 1 - (2-chloro-6-fluorophenyl) peranone 1 -
Figure imgf000052_0001

2-Chlor-6-fluorbenzonitril (5,0 g, 32,14 mmol, 1,0 equiv) wurde in Diethylether (100 ml) unter Stickstoffatmosphäre gelöst und mit einem Eisbad auf 0 °C gekühlt. Zu der Lösung tropfte man innerhalb von 30 min. eine 3M Ethylmagnesiumbromid-Lösung in Diethylether (11,79 ml, 35,36 mmol, 1,1 equiv.) zu. Das resultierende Reaktionsgemisch wurde bei Raumtemperaturüber Nacht gerührt. Anschließend kühlte man die Suspension mit einem Eisbad auf 0 bis 4 °C ab, versetzte diese mit 2M Salzsäure und rührte 2 h bei Raumtemperatur. Danach wurde der pH- Wert durch Zugabe von konz. Ammoniak auf pH 8 eingestellt. Das Reaktionsgemisch wurde dreimal mit jeweils 100 ml 2-Chloro-6-fluorobenzonitrile (5.0 g, 32.14 mmol, 1.0 equiv) was dissolved in diethyl ether (100 ml) under a nitrogen atmosphere and cooled to 0 ° C with an ice bath. To the solution was added dropwise within 30 min. add a 3M ethyl magnesium bromide solution in diethyl ether (11.79 mL, 35.36 mmol, 1.1 equiv.). The resulting reaction mixture was stirred at room temperature overnight. Subsequently, the suspension was cooled to 0 to 4 ° C. with an ice bath, mixed with 2M hydrochloric acid and stirred for 2 hours at room temperature. Thereafter, the pH was reduced by adding conc. Ammonia adjusted to pH 8. The reaction mixture was washed three times with 100 ml each time

Dichlormethan extrahiert. Die organische Phase trocknete man über Magnesiumsulfat und entfernte das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/H eptan) des resultierenden Rohproduktes konnte l-(2-Chlor-6-fluorphenyl)propan-l -on in Form eines gelben Öls isoliert werden (5,05 g, 78% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.30 (d, 1H), 7.20 (d, 1H), 7.03 (t, 1H), 2.85 (q, 2H), 1.22 (t, 3H). Extracted dichloromethane. The organic phase was dried over magnesium sulfate and the solvent removed in vacuo. Final purification by column chromatography (gradient of ethyl acetate / hexane) of the resulting crude product gave l- (2-chloro-6-fluorophenyl) propan-1-one in Form a yellow oil (5.05 g, 78% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 7.30 (d, 1H), 7.20 (d, 1H), 7.03 (t, 1H), 2.85 (q, 2H), 1.22 (t, 3H).

Synthesestufe 2: (2E)-l-(2-Chlor-6-fluorphen l)-3-(dimethylamino)-2-methylprop-2-en-l-on Synthesis step 2: (2E) -l- (2-chloro-6-fluorophenol) -3- (dimethylamino) -2-methylprop-2-en-1-one

Figure imgf000053_0001
Figure imgf000053_0001

l-(2-Chlor-6-fluorphenyl)propan-l-on (4,1 g, 18,68 mmol, 1,0 equiv) und 1 , 1 -Dimethoxy-N,N- dimethylmethanamin (9,89 ml, 74,70 mmol, 4 equiv) wurden in DMF (45 ml) gelöst und über Nacht 90 °C erhitzt und anschließend im Vakuum eingeengt. Das Rohprodukt wurde ohne weitere Aufreinigung in der nächsten Synthesestufe eingesetzt. 1- (2-chloro-6-fluorophenyl) propan-1-one (4.1 g, 18.68 mmol, 1.0 equiv) and 1, 1-dimethoxy-N, N-dimethylmethanamine (9.89 mL, 74.70 mmol, 4 equiv) were dissolved in DMF (45 ml) and heated at 90 ° C overnight and then concentrated in vacuo. The crude product was used without further purification in the next stage of the synthesis.

Synthesestufe 3: 3-(2-Chlor-6-fluorphenyl)-4-methyl-lH-pyrazol Synthesis step 3: 3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazole

Figure imgf000053_0002
Figure imgf000053_0002

(2E)-l-(2-Chlor-6-fluorphenyl)-3-(dimethylamino)-2-methylprop-2-en-l-on (7,3 g, 30,20 mmol, 1,0 equiv) wurde in Ethanol (90 ml) gelöst, und mit Hydrazinhydrat (4,41 ml, 90,61 mmol, 3,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 8 h auf eine Temperatur von 80 °C erhitzt. Nach dem Abkühlen auf Raumtemperatur entfernte man das Lösungsmittel im Vakuum. (2E) -1- (2-chloro-6-fluorophenyl) -3- (dimethylamino) -2-methylprop-2-en-1-one (7.3 g, 30.20 mmol, 1.0 equiv.) in ethanol (90 ml) and treated with hydrazine hydrate (4.41 ml, 90.61 mmol, 3.0 equiv). The resulting reaction mixture was heated to a temperature of 80 ° C for 8 hours. After cooling to room temperature, the solvent was removed in vacuo.

Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 3-(2-Chlor-6-fluorphenyl)-4-methyl-lH-pyrazol in Form eines gelben Öls isoliert werden (3,3 g, 44% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 8.65 (bs, 1H), 7.48 (s, 1H), 7.30 (m, 2H), 7.09 (t, 1H), 2.00 (s, 3H).  By final column chromatographic purification (gradient ethyl acetate / heptane) of the resulting crude product 3- (2-chloro-6-fluorophenyl) -4-methyl-lH-pyrazole was isolated as a yellow oil (3.3 g, 44% of theory ). 'H NMR (400 MHz, CDCl3 δ, ppm) 8.65 (bs, 1H), 7.48 (s, 1H), 7.30 (m, 2H), 7.09 (t, 1H), 2.00 (s, 3H).

Synthesestufe 4: Ethyl-2-[3-(2-chlor-6-fluorphenyl)-4-methyl-lH-pyrazol-l -yl]-2-methylpropanoat

Figure imgf000054_0001
Synthesis Step 4: Ethyl 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methylpropanoate
Figure imgf000054_0001

3-(2-Chlor-6-fluorphenyl)-4-methyl-lH-pyrazol (1,15 g, 5,46 mmol, 1,0 equiv), Ethyl-2-brom-2- methylpropanoat (1,00 ml, 6,83 mmol, 1,25 equiv) und Caesiumcarbonat (3,56 g, 10,92 mmol, 2,0 equiv) wurden in DMF (22 ml) gelöst und 6 h auf 100 °C erhitzt. Nach dem Abkühlen wurde das Reaktionsgemisch in Wasser (50 ml) gegossen und zweimal mit jeweils 50 ml Ethylacetat extrahiert. Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch 3- (2-Chloro-6-fluorophenyl) -4-methyl-1H-pyrazole (1.15 g, 5.46 mmol, 1.0 equiv), ethyl 2-bromo-2-methylpropanoate (1.00 ml , 6.83 mmol, 1.25 equiv) and cesium carbonate (3.56 g, 10.92 mmol, 2.0 equiv) were dissolved in DMF (22 ml) and heated to 100 ° C for 6 h. After cooling, the reaction mixture was poured into water (50 ml) and extracted twice with 50 ml of ethyl acetate each time. Then the solvent was removed in vacuo and the residue was purified

Säulenchromatographie (Gradient Essigester/Heptan). Ethyl-2-[3-(2-chlor-6-fluorphenyl)-4-methyl- lH-pyrazol-l-yl]-2-methylpropanoat wurde in Form eines gelben Öls isoliert (837 mg, 47% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.46 (s, 1H), 7.27 (m, 2H), 7.04 (m, 1H), 4.16 (q, 2H), 1.96 (s, 3H), 1,87 (s, 6H), 1.20 (t, 3H). Column chromatography (gradient ethyl acetate / heptane). Ethyl 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methylpropanoate was isolated as a yellow oil (837 mg, 47% of theory). 'H NMR (400 MHz, CDC1 3 δ, ppm) 7.46 (s, 1H), 7.27 (m, 2H), 7.04 (m, 1H), 4.16 (q, 2H), 1.96 (s, 3H), 1 , 87 (s, 6H), 1.20 (t, 3H).

Synthesestufe 5: 2-[3-(2-Chlor-6-fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-2-methylpropansäure Synthesis step 5: 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methylpropanoic acid

Figure imgf000054_0002
Figure imgf000054_0002

Ethyl-2-[3-(2-chlor-6-fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-2-methylpropanoat (0,80 g, 2,46 mmol, 1,0 equiv) und Natriumhydroxid (148 mg, 3,70 mmol, 1,5 equiv) wurden in Ethanol (7 ml) und Wasser (7 ml) gelöst und 2 h bei Raumtemperatur gerührt. Man entfernt das Lösungsmittel im Vakuum nimmt den Rückstand in Wasser (15 ml) auf und säuert die Lösung mit 10%iger Salzsäure an, wobei ein weißer Niederschlag entsteht. Den Niederschlag filtrierte man ab und trocknete diesen an der Luft. 2- [3 -(2- Chlor-6-fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-2-methylpropansäure wurde in Form eines weißenEthyl 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methylpropanoate (0.80 g, 2.46 mmol, 1.0 equiv) and Sodium hydroxide (148 mg, 3.70 mmol, 1.5 equiv) was dissolved in ethanol (7 ml) and water (7 ml) and stirred for 2 h at room temperature. The solvent is removed in vacuo and the residue is taken up in water (15 ml) and the solution is acidified with 10% hydrochloric acid to give a white precipitate. The precipitate was filtered off and dried in air. 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methylpropanoic acid was obtained as a white

Feststoffes isoliert (554 mg, 75% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 12.87 (bs, 1H), 7.79 (s, 1H), 7.48 (m, 1H), 7.42 (d, 1H), 7.30 (t, 1H), 1,96 (s, 3H), 1.87 (s, 6H), 1.20 (t, 3H). Synthesestufe 6 : 2- [3 -(2-Chlor-6-fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -2-methyl- 1 -(Pyrrolidin- 1 - yl)propan-l -on (1.73-101) Solid isolated (554 mg, 75% of theory). 'H NMR (400 MHz, CDCl3 δ, ppm) 12.87 (bs, 1H), 7.79 (s, 1H), 7.48 (m, 1H), 7.42 (d, 1H), 7.30 (t, 1H), 1, 96 (s, 3H), 1.87 (s, 6H), 1.20 (t, 3H). Synthesis step 6: 2- [3 - (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methyl-1 - (pyrrolidin-1-yl) propan-1-one (1.73-101)

Figure imgf000055_0001
Figure imgf000055_0001

2- [3 -(2-Chlor-6-fluorphenyl)-4-methyl-l H-pyrazol- l-yl]-2-methylpropansäure (100 mg, 0,34 mmol, 1,0 equiv), 3- {[(Ethylimino)methylen]amino} -N,N-dimethylpropan-l-aminiumchlorid (77,53 mg, 0,40 mmol, 1,20 equiv.), N,N-Diisopropylethylamin (176 μΐ, 1,01 mmol, 3,0 equiv.), Pyrrolidin (35 μΐ, 0,42 mmol, 1,25 equiv.) und lH-Benzotriazol-l -olhydrat (1 : 1) (61,93 mg, 0,40 mmol, 1,2 equiv) wurden in DMF (3 ml) gelöst und 8 h auf 80 °C erhitzt. Nach dem Abkühlen verdünnte man das Reaktionsgemisch mit gesättigter Natriumhydrogencarbonat-Lösung (3 ml) und extrahierte danach mit DCM. Die Phasen wurden mit einem Phasenseparator getrennt. Man entfernte das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 2- [3 -(2-Chlor-6-fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -2-methyl- 1 -(pyrrolidin- l-yl)propan-l-on in Form eines weißen Feststoffes isoliert werden (95 mg, 80% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.39 (s, 1H), 7.28 (m, 2H), 7.06 (m, 1H), 3.52 (t, 1H), 2.66 (t, 2H), 1.95 (s, 3H), 1.83 (s, 6H), 1.71 (m, 4H). 2- [3 - (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methyl-propanoic acid (100 mg, 0.34 mmol, 1.0 equiv), 3 { [(Ethylimino) methylene] amino} -N, N-dimethylpropane-1-amino-chloride (77.53 mg, 0.40 mmol, 1.20 equiv.), N, N-diisopropylethylamine (176 μΐ, 1.01 mmol, 3.0 equiv.), Pyrrolidine (35 μΐ, 0.42 mmol, 1.25 equiv.) And 1H-benzotriazole 1-ol hydrate (1: 1) (61.93 mg, 0.40 mmol, 1.2 equiv) were dissolved in DMF (3 ml) and heated to 80 ° C for 8 h. After cooling, the reaction mixture was diluted with saturated sodium bicarbonate solution (3 ml) and then extracted with DCM. The phases were separated with a phase separator. The solvent was removed in vacuo. Final purification by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product afforded 2- [3- (2-chloro-6-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -2-methyl-1 - ( pyrrolidin-1-yl) propan-1-one in the form of a white solid (95 mg, 80% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 7.39 (s, 1H), 7.28 (m, 2H), 7.06 (m, 1H), 3.52 (t, 1H), 2.66 (t, 2H), 1.95 (s, 3H), 1.83 (s, 6H), 1.71 (m, 4H).

Synthesebeispiel No. 1.46-167: Synthesis Example No. 1.46-167:

Synthesestufel : l-(3-Fluorpyridin-2-yl)ethanon

Figure imgf000055_0002
Synthesis test: 1- (3-fluoropyridin-2-yl) ethanone
Figure imgf000055_0002

3-Fluorpyridin-2-carbonitril (8,0 g, 65,52 mmol, 1.0 equiv) wurde in Diethylether (150 ml) unter Stickstoffatmosphäre gelöst und mit einem Eisbad auf 0 °C gekühlt. Zu der Lösung tropfte man innerhalb von 30 min. eine 3M Methylmagnesiumbromid-Lösung in Diethylether (24,02 ml, 72,07 mmol) zu. Das resultierende Reaktionsgemisch wurde bei Raumtemperaturüber Nacht gerührt. 3-Fluoropyridine-2-carbonitrile (8.0 g, 65.52 mmol, 1.0 equiv) was dissolved in diethyl ether (150 ml) under a nitrogen atmosphere and cooled to 0 ° C with an ice-bath. To the solution was added dropwise within 30 min. add a 3M methylmagnesium bromide solution in diethyl ether (24.02mL, 72.07mmol). The resulting reaction mixture was stirred at room temperature overnight.

Anschließend kühlte man die Suspension mit einem Eisbad auf 0 bis 4 °C ab, versetzte diese mit 2M Salzsäure und rührte 2 h bei Raumtemperatur. Danach wurde der pH- Wert durch Zugabe von konz. Ammoniak auf pH 8 eingestellt. Das Reaktionsgemisch wurde dreimal mit jeweils 100 ml Subsequently, the suspension was cooled to 0 to 4 ° C. with an ice bath, mixed with 2M hydrochloric acid and stirred for 2 hours at room temperature. Thereafter, the pH was reduced by adding conc. Ammonia adjusted to pH 8. The reaction mixture was washed three times with 100 ml each time

Dichlormethan extrahiert. Die organische Phase trocknete man über Magnesiumsulfat und entfernte das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/H eptan) des resultierenden Rohproduktes konnte l-(3-Fluorpyridin-2-yl)ethanon in Form eines farblosen Feststoffes isoliert werden (5,31 g, 58% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 8.51 (m, IH), 7.52 (m, 2H), 2.72 (s, 3H). Extracted dichloromethane. The organic phase was dried over magnesium sulfate and the solvent removed in vacuo. Final purification by column chromatography (gradient of ethyl acetate / hexane) of the resulting crude product afforded l- (3-fluoropyridin-2-yl) ethanone as a colorless solid (5.31 g, 58% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 8:51 (m, IH), 7:52 (m, 2H), 2.72 (s, 3H).

Synthesestufe 2: (2E)-3-(Dimethylamino)-l -(3-fluorpyridin-2-yl)prop-2-en-l-on Synthesis step 2: (2E) -3- (dimethylamino) -1- (3-fluoropyridin-2-yl) prop-2-en-1-one

Figure imgf000056_0001
Figure imgf000056_0001

l-(3-Fluorpyridin-2-yl)ethanon (5,00 g, 35,94 mmol, 1.0 equiv) und 1 , 1 -Dimethoxy-N,N- dimethylmethanamin (19,03 ml, 143,75 mmol, 4 equiv) wurden in DMF (60 ml) gelöst und über Nacht 90 °C erhitzt und anschließend im Vakuum eingeengt. Das Rohprodukt wurde ohne weitere 1- (3-fluoropyridin-2-yl) ethanone (5.00 g, 35.94 mmol, 1.0 equiv) and 1, 1-dimethoxy-N, N-dimethylmethanamine (19.03 mL, 143.75 mmol, 4 equiv) were dissolved in DMF (60 ml) and heated at 90 ° C overnight and then concentrated in vacuo. The crude product was without further

Aufreinigung in der nächsten Synthesestufe eingesetzt. Synthesestufe 3 : 3-Fluor-2-(lH-pyrazol-3-yl)pyridin Purification used in the next stage of the synthesis. Synthesis Step 3: 3-Fluoro-2- (1H-pyrazol-3-yl) pyridine

Figure imgf000056_0002
Figure imgf000056_0002

(2E)-3-(Dimethylamino)-l-(3-fluorpyridin-2-yl)prop-2-en-l-on (6,5 g, 35,90 mmol, 1,0 equiv) wurde in Ethanol (30 ml) gelöst, und mit Hydrazinhydrat (7,06 ml, 143,60 mmol, 4,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 8 h auf eine Temperatur von 80 °C erhitzt. Nach dem Abkühlen auf Raumtemperatur entfernte man das Lösungsmittel im Vakuum. Durch abschließende (2E) -3- (Dimethylamino) -1- (3-fluoropyridin-2-yl) prop-2-en-1-one (6.5 g, 35.90 mmol, 1.0 equiv) was dissolved in ethanol ( 30 ml), and hydrazine hydrate (7.06 ml, 143.60 mmol, 4.0 equiv.) Was added. The resulting reaction mixture was heated to a temperature of 80 ° C for 8 hours. After cooling to room temperature, the solvent was removed in vacuo. By final

säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 3-Fluor-2-(lH-pyrazol-3-yl)pyridin in Form eines gelben Öls isoliert werden (6,40 g, 98% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 8.45 (m, IH), 7.71 (d, IH), 7.51 (t, IH), 7.28 (m, IH), 6,93 (m, IH). column chromatographic purification (gradient ethyl acetate / heptane) of the resulting crude product, 3-fluoro-2- (1H-pyrazol-3-yl) pyridine was isolated as a yellow oil (6.40 g, 98% of theory). 'H NMR (400 MHz, CDCl3 δ, ppm) 8.45 (m, IH), 7.71 (d, IH), 7.51 (t, IH), 7.28 (m, IH), 6.93 (m, IH).

Synthesestufe 4: 2-(4-Brom-lH-pyrazol-3-yl)-3-fluorpyridin

Figure imgf000057_0001
Synthesis step 4: 2- (4-bromo-1H-pyrazol-3-yl) -3-fluoropyridine
Figure imgf000057_0001

3-Fluor-2-(lH-pyrazol-3-yl)pyridin (1,88 g, 35,90 mmol, 1,0 equiv) wurde in Dichlormethan (35 ml) gelöst und portionsweise mit N-Bromsuccinimid (2,06 g, 11,55 mmol, 1,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde über Nacht bei Raumtemperatur gerührt. Das Reaktionsgemisch wurde mit einer gesättigten Natriumthiosulfat-Lösung behandelt. Die Phasen trennte man mit einem Phasenseparator. Durch abschließende säulenchromatographische Reinigung (Gradient 3-Fluoro-2- (1H-pyrazol-3-yl) pyridine (1.88 g, 35.90 mmol, 1.0 equiv) was dissolved in dichloromethane (35 ml) and partitioned with N-bromosuccinimide (2.06 g, 11.55 mmol, 1.0 equiv). The resulting reaction mixture was stirred at room temperature overnight. The reaction mixture was treated with a saturated sodium thiosulfate solution. The phases were separated with a phase separator. By final column chromatographic purification (gradient

Essigester/Heptan) des resultierenden Rohproduktes 2-(4-Brom-lH-pyrazol-3-yl)-3-fluorpyridin in Form eines weißen Feststoffes isoliert werden (1,10 g, 37% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 13.53 (s, 1H), 8.55 (s, 1H), 8.10 (s, 1H), 7.87 (m, 1H), 7.57 (m, 1H). Ethyl acetate / heptane) of the resulting crude product 2- (4-bromo-1H-pyrazol-3-yl) -3-fluoropyridine in the form of a white solid (1.10 g, 37% of theory). 'H NMR (400 MHz, CDC1 3 δ, ppm) 13.53 (s, 1H), 8.55 (s, 1H), 8.10 (s, 1H), 7.87 (m, 1H), 7.57 (m, 1H).

Synthesestufe 5 : Ethyl-2- [4-brom-3 -(3 -fluorpyridin-2-yl)- 1 H-pyrazol- 1 -yl] -2-methylpropanoat Synthesis Step 5: Ethyl 2- [4-bromo-3 - (3-fluoropyridin-2-yl) -1 H -pyrazol-1-yl] -2-methylpropanoate

Figure imgf000057_0002
Figure imgf000057_0002

2-(4-Brom-lH-pyrazol-3-yl)-3-fluorpyridin (1,00 g, 4,13 mmol, 1,0 equiv), Ethyl-2-brom-2- methylpropanoat (0,76 ml, 5,16 mmol, 1,25 equiv) und Caesiumcarbonat (2,69 g, 8,26 mmol, 2,0 equiv) wurden in DMF (15 ml) gelöst und 6 h auf 100 °C erhitzt. Nach dem Abkühlen wurde das 2- (4-Bromo-1H-pyrazol-3-yl) -3-fluoropyridine (1.00 g, 4.13 mmol, 1.0 equiv), ethyl 2-bromo-2-methylpropanoate (0.76 ml , 5.16 mmol, 1.25 equiv) and cesium carbonate (2.69 g, 8.26 mmol, 2.0 equiv) were dissolved in DMF (15 mL) and heated to 100 ° C for 6 h. After cooling, the

Reaktionsgemisch in Wasser (50 ml) gegossen und dreimal mit jeweils 20 ml Ethylacetat extrahiert. Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch The reaction mixture was poured into water (50 ml) and extracted three times with 20 ml of ethyl acetate each time. Then the solvent was removed in vacuo and the residue was purified

Säulenchromatographie (Gradient Essigester/Heptan). Ethyl-2-[4-brom-3-(3-fluorpyridin-2-yl)-lH- pyrazol-l-yl] -2-methylpropanoat wurde in Form eines gelben Öls isoliert (1,18 g, 79%> der Theorie). 'H- NMR (400 MHz, CDCI3 δ, ppm) 8.56 (s, 1H), 7.72 (s, 1H), 7.49 (t, 1H), 7,35 (m, 1H), 4.18 (q, 2H), 1.89 (s, 6H), 1.22 (t, 3H). Column chromatography (gradient ethyl acetate / heptane). Ethyl 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -2-methylpropanoate was isolated as a yellow oil (1.18 g, 79%> Theory). 'H NMR (400 MHz, CDCl3 δ, ppm) 8.56 (s, 1H), 7.72 (s, 1H), 7.49 (t, 1H), 7.35 (m, 1H), 4.18 (q, 2H), 1.89 (s, 6H), 1.22 (t, 3H).

Synthesestufe 6 : 2- [4-Brom-3 -(3 -fluorpyridin-2-yl)- 1 H-pyrazol- 1 -yl] -2-methylpropansäure

Figure imgf000058_0001
Synthesis step 6: 2- [4-Bromo-3 - (3-fluoropyridin-2-yl) -1 H -pyrazol-1-yl] -2-methylpropanoic acid
Figure imgf000058_0001

Ethyl-2-[4-brom-3-(3-fluorpyridin-2-yl)-lH-pyrazol-l-yl]-2-methylpropanoat (0,15 g, 0,42 mmol, 1,0 equiv) und Natriumhydroxid (25 mg, 0,63 mmol, 1,5 equiv) wurden in Ethanol (3 ml) und Wasser (3 ml) gelöst und 2 h bei Raumtemperatur gerührt. Man entfernt das Lösungsmittel im Vakuum nimmt den Rückstand in Wasser (15 ml) auf und säuert die Lösung mit 10%iger Salzsäure an, wobei ein weißer Niederschlag entsteht. Den Niederschlag filtrierte man ab und trocknete diesen an der Luft. 2-[4-Brom- 3-(3-fluorpyridin-2-yl)-lH-pyrazol-l-yl]-2-methylpropansäurewurde in Form eines weißen Feststoffes isoliert (100 mg, 72% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 8.53 (m, 1H), 8.31 (s, 1H), 7.84 (t, 1H), 7.55 (m, 1H), 1.78 (s, 6H). Ethyl 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -2-methylpropanoate (0.15 g, 0.42 mmol, 1.0 equiv) and Sodium hydroxide (25 mg, 0.63 mmol, 1.5 equiv) was dissolved in ethanol (3 ml) and water (3 ml) and stirred for 2 h at room temperature. The solvent is removed in vacuo and the residue is taken up in water (15 ml) and the solution is acidified with 10% hydrochloric acid to give a white precipitate. The precipitate was filtered off and dried in air. 2- [4-Bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -2-methylpropanoic acid was isolated as a white solid (100 mg, 72% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 8:53 (m, 1H), 8.31 (s, 1H), 7.84 (t, 1H), 7:55 (m, 1H), 1.78 (s, 6H).

Synthesestufe 7: 2-[4-Brom-3-(3-fluorpyridin-2-yl)-lH-pyrazol-l-yl]-N,N,2-trimethylpropanamid (1.46- 167) Synthesis step 7: 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (1.46-167)

Figure imgf000058_0002
Figure imgf000058_0002

2-[4-Brom-3-(3-fluorpyridin-2-yl)-lH-pyrazol-l-yl]-2-methylpropansäure (200 mg, 0,61 mmol, 1,0 equiv), 3- {[(Ethylimino)methylen]amino} -N,N-dimethylpropan-l-aminiumchlorid (143,07 mg, 0,73 mmol, 1,20 equiv.), N,N-Diisopropylethylamin (372 μΐ, 2,13 mmol, 3,5 equiv.), Diethylamin (381 μΐ, 0,76 mmol, 1,25 equiv.) und lH-Benzotriazol-l-olhydrat (1 : 1) (112 mg, 0,73 mmol, 1,2 equiv) wurden in DMF (4 ml) gelöst und 8 h auf 80 °C erhitzt. Nach dem Abkühlen verdünnte man das 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -2-methylpropanoic acid (200 mg, 0.61 mmol, 1.0 equiv), 3: [ (Ethylimino) methylene] amino} -N, N-dimethylpropane-1-amino-chloride (143.07 mg, 0.73 mmol, 1.20 equiv.), N, N-diisopropylethylamine (372 μΐ, 2.13 mmol, 3 , 5 equiv.), Diethylamine (381 μΐ, 0.76 mmol, 1.25 equiv.) And 1H-benzotriazole 1-ol hydrate (1: 1) (112 mg, 0.73 mmol, 1.2 equiv) dissolved in DMF (4 ml) and heated at 80 ° C for 8 h. After cooling, this was diluted

Reaktionsgemisch mit gesättigter Natriumhydrogencarbonat-Lösung (3 ml) und extrahierte danach mit DCM. Die Phasen wurden mit einem Phasenseparator getrennt. Man entfernte das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 2-[4-Brom-3-(3-fluorpyridin-2-yl)-lH-pyrazol-l-yl]-N,N,2- trimethylpropanamid in Form eines gelben Öls isoliert werden (134 mg, 56% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 8.57 (m, 1H), 7.60 (s, 1H), 7.53 (t, 1H), 7.37 (m, 1H), 2.96 (bs, 3H), 2,54 (bs, 3H), 1.86 (s, 6H). Reaction mixture with saturated sodium bicarbonate solution (3 ml) and then extracted with DCM. The phases were separated with a phase separator. The solvent was removed in vacuo. Final purification by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product afforded 2- [4-bromo-3- (3-fluoropyridin-2-yl) -1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide in Form a yellow oil (134 mg, 56% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 8.57 (m, 1H), 7.60 (s, 1H), 7.53 (t, 1H), 7.37 (m, 1H), 2.96 (bs, 3H), 2.54 (bs , 3H), 1.86 (s, 6H).

Synthesebeispiel No. 1.1-303: Synthesis Example No. 1.1-303:

Synthesestufe 1 : (2E)-l-(2,6-Difluorphenyl)-3-(dimethylamino)prop-2-en-l -on Synthesis step 1: (2E) -1- (2,6-difluorophenyl) -3- (dimethylamino) prop-2-en-1-one

Figure imgf000059_0001
l-(2,6-Difluorphenyl)ethanon (5,00 g, 32,02 mmol, 1.0 equiv) und 1 , 1 -Dimethoxy-N,N- dimethylmethanamin (16,96 ml, 143,75 mmol, 4 equiv) wurden in DMF (60 ml) gelöst und über Nacht 90 °C erhitzt und anschließend im Vakuum eingeengt. Das Rohprodukt wurde ohne weitere
Figure imgf000059_0001
1- (2,6-Difluorophenyl) ethanone (5.00 g, 32.02 mmol, 1.0 equiv.) and 1, 1-dimethoxy-N, N-dimethylmethanamine (16.96 ml, 143.75 mmol, 4 equiv.). were dissolved in DMF (60 ml) and heated at 90 ° C overnight and then concentrated in vacuo. The crude product was without further

Aufreinigung in der nächsten Synthesestufe eingesetzt. Purification used in the next stage of the synthesis.

Synthesestufe 2: 3-(2,6-Difluorphenyl)-lH-pyrazol Synthesis step 2: 3- (2,6-Difluorophenyl) -1H-pyrazole

Figure imgf000059_0002
Figure imgf000059_0002

(2E)-l-(2,6-Difluorphenyl)-3-(dimethylamino)prop-2-en-l-on (6,76 g, 30,40 mmol, 1,0 equiv) wurde in Ethanol (60 ml) gelöst, und mit Hydrazinhydrat (4,44 ml, 143,60 mmol, 3,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 8 h auf eine Temperatur von 80 °C erhitzt. Nach dem Abkühlen auf Raumtemperatur entfernte man das Lösungsmittel im Vakuum. Durch abschließende (2E) -1- (2,6-Difluorophenyl) -3- (dimethylamino) prop-2-en-1-one (6.76 g, 30.40 mmol, 1.0 equiv) was dissolved in ethanol (60 ml ), and hydrazine hydrate (4.44 ml, 143.60 mmol, 3.0 equiv) was added. The resulting reaction mixture was heated to a temperature of 80 ° C for 8 hours. After cooling to room temperature, the solvent was removed in vacuo. By final

säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 3-(2,6-Difluorphenyl)-lH-pyrazol in Form eines weißen Feststoffes isoliert werden (5,65 g, 99% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 7.70 (d, 1H), 7.29 (m, 1H), 7.04 (t, 2H), 6.84 (d, 1H). Synthesestufe 3 : Ethyl-2-[3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropanoat

Figure imgf000060_0001
column chromatographic purification (gradient ethyl acetate / heptane) of the resulting crude product, 3- (2,6-difluorophenyl) -1H-pyrazole was isolated as a white solid (5.65 g, 99% of theory). 'H NMR (400 MHz, CDCl3 δ, ppm) 7.70 (d, 1H), 7.29 (m, 1H), 7.04 (t, 2H), 6.84 (d, 1H). Synthesis Step 3: Ethyl 2- [3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoate
Figure imgf000060_0001

3-(2,6-Difluorphenyl)-lH-pyrazol (5,97 g, 18,55 mmol, 1,0 equiv), Ethyl-2-brom-2-methylpropanoat (3,40 ml, 23,18 mmol, 1,25 equiv) und Caesiumcarbonat (12,09 g, 37,09 mmol, 2,0 equiv) wurden in DMF (65 ml) gelöst und 6 h auf 100 °C erhitzt. Nach dem Abkühlen wurde das Reaktionsgemisch in Wasser (100 ml) gegossen und dreimal mit jeweils 100 ml Ethylacetat extrahiert. Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch Säulenchromatographie 3- (2,6-Difluorophenyl) -1H-pyrazole (5.97 g, 18.55 mmol, 1.0 equiv), ethyl 2-bromo-2-methylpropanoate (3.40 mL, 23.18 mmol, 1.25 equiv) and cesium carbonate (12.09 g, 37.09 mmol, 2.0 equiv) were dissolved in DMF (65 ml) and heated to 100 ° C for 6 h. After cooling, the reaction mixture was poured into water (100 ml) and extracted three times with 100 ml of ethyl acetate each time. Then the solvent was removed in vacuo and the residue was purified by column chromatography

(Gradient Essigester/Heptan). Ethyl-2- [3-(2,6-difluorphenyl)- 1 H-pyrazol- 1 -yl] -2-methylpropanoat wurde in Form eines gelben Öls isoliert (2,66 g, 48% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.65 (d, 1H), 7.25 (m, 1H), 6.94 (t, 2H), 6,58 (d, 1H), 4.17 (q, 2H), 1.90 (s, 6H), 1.21 (t, 3H). (Gradient vinegar / heptane). Ethyl 2- [3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoate was isolated as a yellow oil (2.66 g, 48% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 7.65 (d, 1H), 7.25 (m, 1H), 6.94 (t, 2H), 6.58 (d, 1H), 4.17 (q, 2H) , 1.90 (s, 6H), 1.21 (t, 3H).

Synthesestufe 4: 2-[3-(2,6-Difluorphenyl)-lH- razol-l-yl]-2-methylpropansäure Synthesis step 4: 2- [3- (2,6-Difluorophenyl) -1H-razol-1-yl] -2-methylpropanoic acid

Figure imgf000060_0002
Figure imgf000060_0002

Ethyl-2-[3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropanoat (2,50 g, 8,50 mmol, 1,0 equiv) und Natriumhydroxid (509 mg, 12,74 mmol, 1,5 equiv) wurden in Ethanol (25 ml) und Wasser (25 ml) gelöst und 2 h bei Raumtemperatur gerührt. Man entfernt das Lösungsmittel im Vakuum nimmt den Rückstand in Wasser (200 ml) auf und säuert die Lösung mit 2 M Salzsäure an, wobei ein weißer Niederschlag entsteht. Den Niederschlag filtrierte man ab und trocknete diesen an der Luft. 2-[3-(2,6- Difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropansäure wurde in Form eines weißen Feststoffes isoliert (2,19 g, 96% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 12.99 (bs, 1H), 8.01 (d, 1H), 7.44 (m, 1H), 7.17 (t, 1H), 6.55 (d, 1H), 1.78 (s, 6H). Ethyl 2- [3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoate (2.50 g, 8.50 mmol, 1.0 equiv.) And sodium hydroxide (509 mg, 12 , 74 mmol, 1.5 equiv) were dissolved in ethanol (25 ml) and water (25 ml) and stirred for 2 h at room temperature. The solvent is removed in vacuo, the residue is taken up in water (200 ml) and the solution is acidified with 2 M hydrochloric acid to give a white precipitate. The precipitate was filtered off and dried in air. 2- [3- (2,6-Difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoic acid was isolated as a white solid (2.19 g, 96% of theory). 'H-NMR (400 MHz, CDCl3 δ, ppm) 12.99 (bs, 1H), 8.01 (d, 1H), 7.44 (m, 1H), 7.17 (t, 1H), 6.55 (d, 1H), 1.78 ( s, 6H).

Synthesestufe 5: 2-[3-(2,6-Difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropanoylchlorid

Figure imgf000061_0001
Synthesis step 5: 2- [3- (2,6-Difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoyl chloride
Figure imgf000061_0001

2-[3-(2,6-Difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropansäure (1,40 g, 5,26 mmol, 1,0 equiv) und Thionylchlorid (575 μΐ, 7,89 mmol, 1,5 equiv) wurden in Dichlormethan (70 ml) gelöst und 3 h zum Sieden erhitzt. Nach dem Abkühlen entfernte man das Lösungsmittel im Vakuum und setzte das Produkte sofort ohne weitere Aufreinigung in der nächsten Stufe ein. 2- [3- (2,6-Difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoic acid (1.40 g, 5.26 mmol, 1.0 equiv) and thionyl chloride (575 μΐ, 7.89 mmol, 1.5 equiv) were dissolved in dichloromethane (70 ml) and heated to boiling for 3 h. After cooling, the solvent was removed in vacuo and the product was immediately added to the next step without further purification.

Synthesestufe 6: 2-[3-(2,6-Difluorphenyl)-lH-pyrazol-l-yl]-N-methoxy-N,2-dimethylpropanamid (1.1- 303) Synthesis step 6: 2- [3- (2,6-Difluorophenyl) -1H-pyrazol-1-yl] -N-methoxy-N, 2-dimethylpropanamide (1.1-303)

Figure imgf000061_0002
Figure imgf000061_0002

2-[3-(2,6-Difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropanoylchlorid (108 mg, 0,38 mmol, 1,0 equiv), N-Methoxymethanaminhydrochlorid (55,60 mg, 0,57 mmol, 1,5 equiv) und Triethylamin (265 μΐ, 1,90 mmol, 5 equiv) wurden in Dichlormethan (3 ml) gelöst und über Nacht bei Raumtemperatur gerührt.2- [3- (2,6-Difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoyl chloride (108 mg, 0.38 mmol, 1.0 equiv), N-methoxymethanamine hydrochloride (55.60 mg, 0 , 57 mmol, 1.5 equiv) and triethylamine (265 μΐ, 1.90 mmol, 5 equiv) were dissolved in dichloromethane (3 ml) and stirred overnight at room temperature.

Man verdünnt mit Dichlormethan (5 ml) und wäscht mit Wasser (2 ml). Die Phasen trennte man mit einem Phasenseparator. Durch abschließende säulenchromatographische Reinigung (Gradient Dilute with dichloromethane (5 ml) and wash with water (2 ml). The phases were separated with a phase separator. By final column chromatographic purification (gradient

Essigester/Heptan) des resultierenden Rohproduktes konnte 2-[3-(2,6-Difluorphenyl)-lH-pyrazol-l-yl]- N-methoxy-N,2-dimethylpropanamid in Form eines farblosen Öls isoliert werden (95 mg, 80% der Ethyl acetate / heptane) of the resulting crude product, it was possible to isolate 2- [3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -N-methoxy-N, 2-dimethylpropanamide in the form of a colorless oil (95 mg, 80% of

Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.63 (d, 1H), 7.24 (m, 1H), 6.94 (t, 2H), 6.57 (d, 1H),Theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 7.63 (d, 1H), 7.24 (m, 1H), 6.94 (t, 2H), 6.57 (d, 1H),

3.16 (bs, 3H), 2.97 (bs, 3H), 1.86 (s, 6H). 3.16 (bs, 3H), 2.97 (bs, 3H), 1.86 (s, 6H).

Synthesebeispiel No. 1.116-211 : Synthesestufel : 2-Brom-l -(3-fluorpyridin-2-yl)ethanonhydrobromid (1 : 1) Synthesis Example No. 1.116-211: Synthesis test: 2-bromo-1- (3-fluoropyridin-2-yl) ethanone hydrobromide (1: 1)

Figure imgf000062_0001
l-(3-fluorpyridin-2-yl)ethanon (4,1 g, 29,47 mmol, 1.0 equiv) wurde in Eisessig (30 ml) gelöst und anschließend mit 32 %igen HBr-Lösung in Eisessig (30 ml) versetzt, wobei sich ein gelber Feststoff bildete. Dieser Feststoff löste sich innerhalb von 15 min wieder. Anschließend tropfte man Brom (1,67 ml, 32,42 mmol, 1,1 equiv.) gelöst in Eisessig (10 ml) zu und rührte das Reaktionsgemisch über Nacht bei Raumtemperatur. Danach verdünnte man das Reaktionsgemisch mit Diethylether (100 ml) und filtrierte den Niederschlag ab. Der Niederschlag wurde mit Dieethylether (50 ml) gewaschen und an der Luft getrocknet. 2-Brom- 1 -(3 -fluorpyridin-2-yl)ethanonhydrobromid (1 : 1) wurden in Form eines weißen Feststoffes isoliert (3,98 g, 44% der Theorie). 'H-NMR (400 MHz, DMSO-d6 δ, ppm) 8.58 (d, 1H), 7.96 (dd, 1H), 7.81 (m, 1H), 5.01 (bs, 1H), 4.96 (s, 2H).
Figure imgf000062_0001
1- (3-fluoropyridin-2-yl) ethanone (4.1 g, 29.47 mmol, 1.0 equiv) was dissolved in glacial acetic acid (30 ml), then 32% HBr solution in glacial acetic acid (30 ml) was added , whereupon a yellow solid formed. This solid redissolved within 15 minutes. Then, bromine (1.67 ml, 32.42 mmol, 1.1 equiv.) Dissolved in glacial acetic acid (10 ml) was added dropwise, and the reaction mixture was stirred overnight at room temperature. Thereafter, the reaction mixture was diluted with diethyl ether (100 ml) and the precipitate was filtered off. The precipitate was washed with diethyl ether (50 ml) and dried in air. 2-Bromo-1- (3-fluoropyridin-2-yl) ethanone hydrobromide (1: 1) was isolated as a white solid (3.98 g, 44% of theory). 'H-NMR (400 MHz, DMSO-d 6 δ, ppm) 8:58 (d, 1H), 7.96 (dd, 1H), 7.81 (m, 1H), 5.01, (bs, 1H), 4.96 (s, 2H) ,

Synthesestufe 2: l-(3-Fluorpyridin-2-yl)-2-methoxyethanon

Figure imgf000062_0002
Synthesis step 2: 1- (3-fluoropyridin-2-yl) -2-methoxy-ethanone
Figure imgf000062_0002

2-Brom-l-(3-fluorpyridin-2-yl)ethanonhydrobromid (1 : 1) (10,0 g, 40,48 mmol, 1,0 equiv) wurde in Methanol (50 ml) gelöst und bei Raumtemperatur Bortrifluoretherat () und SilbercarbonatQ versetzt. Das Reaktionsgemisch rührte man 16h bei 60 °C und entfernte dann das Lösungsmittel im Vakuum. Den Rückstand nahm man in Wasser (150 ml) auf und extrahierte zweimal mit Ethylacetat (ä 500 ml). 2-Bromo-1- (3-fluoropyridin-2-yl) ethanone hydrobromide (1: 1) (10.0 g, 40.48 mmol, 1.0 equiv) was dissolved in methanol (50 ml) and boron trifluoroetherate ( ) and silver carbonate. The reaction mixture was stirred for 16 h at 60 ° C and then the solvent was removed in vacuo. The residue was taken up in water (150 ml) and extracted twice with ethyl acetate (a 500 ml).

Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch Then the solvent was removed in vacuo and the residue was purified

Säulenchromatographie (Gradient Essigester/Heptan). l-(3-Fluorpyridin-2-yl)-2-methoxyethanon wurde in Form eines farblosen Öls isoliert (5,1 g, 58% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 8.45 (d, 1H), 7.55 (m, 2H), 4.90 (s, 2H), 3.51 (s, 3H). Column chromatography (gradient ethyl acetate / heptane). 1- (3-fluoropyridin-2-yl) -2-methoxy-ethanone was isolated as a colorless oil (5.1 g, 58% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 8.45 (d, 1H), 7:55 (m, 2H), 4.90 (s, 2H), 3.51, (s, 3H).

Synthesestufe 3: (2Z)-3-(Dimethylamino)-l -(3-fluorpyridin-2-yl)-2-methoxyprop-2-en-l -on Synthesis Step 3: (2Z) -3- (Dimethylamino) -1- (3-fluoropyridin-2-yl) -2-methoxyprop-2-en-1-one

Figure imgf000062_0003
l-(3-Fluorpyridin-2-yl)-2-methoxyethanon (5,00 g, 29,56 mmol, 1.0 equiv) und 1 , 1 -Dimethoxy-N,N- dimethylmethanamin (11,74 ml, 88,68 mmol, 3 equiv) wurden in DMF (30 ml) gelöst und über Nacht 90 °C erhitzt und anschließend im Vakuum eingeengt. Das Rohprodukt wurde ohne weitere Aufreinigung in der nächsten Synthesestufe eingesetzt. 'H-NMR (400 MHz, CDC13 δ, ppm) 8.40 (m, 1H), 7.45 (dd, 1H), 7.34 (m, 1H), 6.48 (bs, 1H), 3.98 (s, 3H), 3.92 (s, 3H), 3.37 (s, 3H).
Figure imgf000062_0003
1- (3-fluoropyridin-2-yl) -2-methoxy-ethanone (5.00 g, 29.56 mmol, 1.0 equiv) and 1, 1-dimethoxy-N, N-dimethylmethanamine (11.74 mL, 88.68 mmol, 3 equiv) were dissolved in DMF (30 ml) and heated at 90 ° C overnight and then concentrated in vacuo. The crude product was used without further purification in the next stage of the synthesis. 'H-NMR (400 MHz, CDC1 3 δ, ppm) 8:40 (m, 1H), 7:45 (dd, 1H), 7:34 (m, 1H), 6:48 (bs, 1H), 3.98 (s, 3H), 3.92 (s, 3H), 3.37 (s, 3H).

Synthesestufe 4: 3-Fluor-2-(4-methoxy-lH-pyrazol-3-yl)pyridin Synthesis Stage 4: 3-Fluoro-2- (4-methoxy-1H-pyrazol-3-yl) pyridine

Figure imgf000063_0001
Figure imgf000063_0001

(2Z)-3-(Dimethylamino)-l-(3-fluorpyridin-2-yl)-2-methoxyprop-2-en-l-on (6,61 g, 29,50 mmol, 1,0 equiv) wurde in Ethanol (60 ml) gelöst, und mit Hydrazinhydrat (4,29 ml, 88,50 mmol, 3,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 8 h auf eine Temperatur von 80 °C erhitzt. Nach dem Abkühlen auf Raumtemperatur entfernte man das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 3-Fluor-2-(4-methoxy-lH-pyrazol-3-yl)pyridin in Form eines gelben Feststoffes isoliert werden (3,00 g, 52% der Theorie). 'H-NMR (400 MHz, CDCI3 δ, ppm) 10.77 (bs, 1H), 8.51 (m, 1H), 7.49 (m, 2H), 7.24 (m, 1H), 3.92 (s, 3H). (2Z) -3- (Dimethylamino) -1- (3-fluoropyridin-2-yl) -2-methoxyprop-2-en-1-one (6.61 g, 29.50 mmol, 1.0 equiv.) dissolved in ethanol (60 ml) and treated with hydrazine hydrate (4.29 ml, 88.50 mmol, 3.0 equiv). The resulting reaction mixture was heated to a temperature of 80 ° C for 8 hours. After cooling to room temperature, the solvent was removed in vacuo. Final purification by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product allowed 3-fluoro-2- (4-methoxy-1H-pyrazol-3-yl) pyridine to be isolated as a yellow solid (3.00 g, 52% of Theory). 'H NMR (400 MHz, CDCl3 δ, ppm) 10.77 (bs, 1H), 8.51 (m, 1H), 7.49 (m, 2H), 7.24 (m, 1H), 3.92 (s, 3H).

Synthesestufe 5: Ethyl-2-[3-(3-fluorpyridin-2-yl)-4-methoxy-lH-pyrazol-l-yl]-2-methylpropanoat Synthesis Step 5: Ethyl 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoate

Figure imgf000063_0002
Figure imgf000063_0002

3-Fluor-2-(4-methoxy-lH-pyrazol-3-yl)pyridin (3,00 g, 15,53 mmol, 1,0 equiv), Ethyl-2-brom-2- methylpropanoat (2,85 ml, 19,41 mmol, 1,25 equiv) und Caesiumcarbonat (10,12 g, 31,06 mmol, 2,0 equiv) wurden in DMF (50 ml) gelöst und 6 h auf 100 °C erhitzt. Nach dem Abkühlen wurde das Reaktionsgemisch in Wasser (100 ml) gegossen und dreimal mit jeweils 75 ml Ethylacetat extrahiert. Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch 3-Fluoro-2- (4-methoxy-1H-pyrazol-3-yl) pyridine (3.00 g, 15.53 mmol, 1.0 equiv), ethyl 2-bromo-2-methylpropanoate (2.85 g ml, 19.41 mmol, 1.25 equiv) and cesium carbonate (10.12 g, 31.06 mmol, 2.0 equiv) were dissolved in DMF (50 ml) and heated to 100 ° C for 6 h. After cooling, the reaction mixture was poured into water (100 ml) and extracted three times with 75 ml of ethyl acetate each time. Then the solvent was removed in vacuo and the residue was purified

Säulenchromatographie (Gradient Essigester/Heptan). Ethyl-2- [3 -(3 -fluorpyridin-2-yl)-4-methoxy- 1 H- pyrazol-l-yl]-2-methylpropanoat wurde in Form eines gelben Öls isoliert (3,03 g, 63% der Theorie). lH- NMR (400 MHz, CDC13 δ, ppm) 8.54 (m, 1H), 7.45 (dd, 1H), 7.32 (s, 1H), 7.24 (m, 1H), 4.18 (q, 2H), 3.83 (s, 3H), 1.89 (s, 6H), 1.22 (t, 3H). Column chromatography (gradient ethyl acetate / heptane). Ethyl 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoate was isolated as a yellow oil (3.03 g, 63% of the yield) Theory). 1 H NMR (400 MHz, CDCl 3 δ, ppm) 8.54 (m, 1H), 7.45 (dd, 1H), 7.32 (s, 1H), 7.24 (m, 1H), 4.18 (q, 2H), 3.83 (s, 3H), 1.89 (s, 6H), 1.22 (t, 3H).

Synthesestufe 6 : 2- [3 -(3 -Fluorpyridin-2-yl)-4-methoxy- 1 H-pyrazol- 1 -yl] -2-methylpropansäure Synthesis step 6: 2- [3 - (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoic acid

Figure imgf000064_0001
Figure imgf000064_0001

Ethyl-2-[3-(3-fluorpyridin-2-yl)-4-methoxy-lH-pyrazol-l-yl]-2-methylpropanoat (3,00 g, 9,76 mmol, 1,0 equiv) und Natriumhydroxid (586 mg, 14,64 mmol, 1,5 equiv) wurden in Ethanol (30 ml) und Wasser (30 ml) gelöst und 2 h bei Raumtemperatur gerührt. Man entfernt das Lösungsmittel im Vakuum nimmt den Rückstand in Wasser (70 ml) auf und säuert die Lösung mit Ethylacetat extrahiert. Die organische Phase trocknete man über Magnesiumsulfat und entfernte das Lösungsmittel im Vakuum. 2- [3-(3-Fluorpyridin-2-yl)-4-methoxy-lH-pyrazol-l-yl]-2-methylpropansäure wurde in Form eines weißen Feststoffes isoliert (2,15 g, 67% der Theorie). 'H-NMR (400 MHz, DMSO-d6 δ, ppm) 8.51 (m, 1H), 7.85 (m, 2H), 7.52 (m, 1H), 3.74 (s, 3H), 1.78 (s, 6H). Synthesestufe 7: 2-[3-(3-Fluorpyridin-2-yl)-4-methoxy-lH-pyrazol-l-yl]-2-methyl-N-(prop-2-in-l- yl)propanamid (1.116-211) Ethyl 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoate (3.00 g, 9.76 mmol, 1.0 equiv) and Sodium hydroxide (586 mg, 14.64 mmol, 1.5 equiv) was dissolved in ethanol (30 ml) and water (30 ml) and stirred for 2 h at room temperature. The solvent is removed in vacuo, the residue is taken up in water (70 ml) and the solution is acidified with ethyl acetate. The organic phase was dried over magnesium sulfate and the solvent removed in vacuo. 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoic acid was isolated as a white solid (2.15 g, 67% of theory). 'H-NMR (400 MHz, DMSO-d 6 δ, ppm) 8:51 (m, 1H), 7.85 (m, 2H), 7:52 (m, 1H), 3.74 (s, 3H), 1.78 (s, 6H) , Synthesis step 7: 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methyl-N- (prop-2-yn-1-yl) propanamide ( 1116-211)

Figure imgf000064_0002
2- [3 -(3 -Fluorpyridin-2-yl)-4-methoxy-l H-pyrazol- 1-yl] -2-methylpropansäure (100 mg, 0,34 mmol, 1,0 equiv), 2,4,6-Tripropyl-l,3,5,2,4,6-trioxatriphosphinan-2,4,6-trioxid (T3P, 275 μΐ, 0,93 mmol, 1,50 equiv.; 50%ig in THF), Triethylamin (301 μΐ, 2,16 mmol, 3,5 equiv.) und Prop-2-in-l -amin (47 μΐ, 0,74 mmol, 1,2 equiv.) wurden in THF (5 ml) gelöst und 8 h bei Raumtemperatur gerührt. Danach verdünnte man das Reaktionsgemisch mit gesättigter Natriumhydrogencarbonat-Lösung 10 ml) und extrahierte danach mit Ethylacetat (10 ml). Die wässrige Phase wurde dreimal mit Ethylacetat extrahiert (10 ml) und die vereinigten organischen Phasen über Magnesiumsulfat getrocknet. Man entfernte das
Figure imgf000064_0002
2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methylpropanoic acid (100 mg, 0.34 mmol, 1.0 equiv), 2.4 , 6-Tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (T3P, 275 μΐ, 0.93 mmol, 1.50 equiv .; 50% in THF), triethylamine (301 μΐ, 2.16 mmol, 3.5 equiv.) And prop-2-in-1-amine (47 μΐ, 0.74 mmol, 1.2 equiv.) Were added in Dissolved THF (5 ml) and stirred for 8 h at room temperature. Thereafter, the reaction mixture was diluted with saturated sodium bicarbonate solution (10 ml) and then extracted with ethyl acetate (10 ml). The aqueous phase was extracted three times with ethyl acetate (10 ml) and the combined organic phases were dried over magnesium sulfate. You removed that

Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 2-[3-(3-Fluorpyridin-2-yl)-4-methoxy-lH- pyrazol-l-yl]-2-methyl-N-(prop-2-in-l-yl)propanamid in Form eines weißen Feststoffes isoliert werden (118 mg, 60% der Theorie). 'H-NMR (400 MHz, DMSO-d6 δ, ppm) 8.48 (m, 1H), 7.85 (m, 1H), 7.74 (m, 2H), 7.46 (m, 1H), 3.83 (dd, 2H), 3.72 (s, 3H), 1.73 (s, 6H). Solvent in a vacuum. Final purification by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product afforded 2- [3- (3-fluoropyridin-2-yl) -4-methoxy-1H-pyrazol-1-yl] -2-methyl-N- (prop -2-in-1-yl) propanamide in the form of a white solid (118 mg, 60% of theory). 'H-NMR (400 MHz, DMSO-d 6 δ, ppm) 8.48 (m, 1H), 7.85 (m, 1H), 7.74 (m, 2H), 7.46 (m, 1H), 3.83 (dd, 2H) , 3.72 (s, 3H), 1.73 (s, 6H).

Synthesebeispiel No. 1.169-101 : Synthesis Example No. 1.169-101:

Synthesestufel : 2-Cyclopropyl-N-methoxy-N-meth lacetamid  Synthesis test: 2-cyclopropyl-N-methoxy-N-methacetamide

Figure imgf000065_0001
Figure imgf000065_0001

Cyclopropylessigsäure (23,00 g, 230 mmol, 1.0 equiv) wurde in Dichlormethan (800 ml) gelöst und anschließend mit Cabonyldiimidazol (CDI, 40,27 g, 248 mmol, 1,08 equiv.) unter Stickstoffatmosphäre versetzt. Das Reaktionsgemisch wurde 2 h bei Raumtemperatur gerührt und anschließend mit N- Methoxymethanaminhydrochlorid (1 :1) (22,88 g, 234 mmol, 1,02 equiv.) versetzt. Das Cyclopropylacetic acid (23.00 g, 230 mmol, 1.0 equiv) was dissolved in dichloromethane (800 ml) and then treated with cabonyldiimidazole (CDI, 40.27 g, 248 mmol, 1.08 equiv.) Under nitrogen atmosphere. The reaction mixture was stirred for 2 h at room temperature and then admixed with N-methoxymethanamine hydrochloride (1: 1) (22.88 g, 234 mmol, 1.02 equiv.). The

Reaktionsgemisch wurde 16 h bei Raumtemperatur gerührt und danach mit Eiswasser und The reaction mixture was stirred for 16 h at room temperature and then with ice water and

Dichlormethan verdünnt. Die organische Phase extrahierte man mit verdünnter Salzsäure und anschließend mit gesättigter Natriumhydrogencarbonat-Lösung. Die vereinigten organischen Phasen wurden über Magnesiumsulfat getrocknet und das Lösungsmittel im Vakuum entfernt. Das Diluted dichloromethane. The organic phase was extracted with dilute hydrochloric acid and then with saturated sodium bicarbonate solution. The combined organic phases were dried over magnesium sulfate and the solvent removed in vacuo. The

resultierenden Rohproduktes 2-Cyclopropyl-N-methoxy-N-methylacetamid wurde in Form eines farblosen Feststoffes isoliert und ohne weitere Aufreinigung in der nächsten Stufe eingesetzt (20,00 g, 62% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 3,65 (s, 3H), 3,17 (s, 3H), 2,33 (d, 2H), 1,08 (m, 1H), 0,53 (m, 2H), 0,17 Im, 2H). resulting crude product 2-cyclopropyl-N-methoxy-N-methylacetamide was isolated as a colorless solid and used without further purification in the next stage (20.00 g, 62% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 3.65 (s, 3H), 3.17 (s, 3H), 2.33 (d, 2H), 1.08 (m, 1H), 0.53 (m, 2H), 0.17 l, 2H).

Synthesestufe 2: 2-Cyclopropyl-l-(2,6-difluorphenyl)ethanon

Figure imgf000065_0002
1,3-Difluorbenzol (7,50 g, 65,78 mmol, 1,0 equiv) wurde in THF (75 ml) gelöst und mit einem Kältebad auf -78°C gekühlt (Stickstoffatmosphäre). Eine 2 M LDA-Lösung (2M in THF, 65,5 ml, 98,67 mmol, 1,50 equiv.) wurde zugetropft. Anschließend rührt man 30 min bei -78 °C nach und versetzt dann mit 2- Cyclopropyl-N-methoxy-N-methylacetamid (11,00 g, 78,94 mmol, 1,20 equiv.). Nach vollständiger Umsetzung (DC-Kontrolle) erwärmt man das Reaktionsgemisch auf 0 °C und versetzt das Synthesis step 2: 2-Cyclopropyl-1- (2,6-difluorophenyl) ethanone
Figure imgf000065_0002
1,3-Difluorobenzene (7.50 g, 65.78 mmol, 1.0 equiv) was dissolved in THF (75 mL) and cooled to -78 ° C with a cold bath (nitrogen atmosphere). A 2M LDA solution (2M in THF, 65.5 mL, 98.67 mmol, 1.50 equiv.) Was added dropwise. The mixture is then stirred for 30 min at -78 ° C and then treated with 2-cyclopropyl-N-methoxy-N-methylacetamide (11.00 g, 78.94 mmol, 1.20 equiv.). After complete reaction (TLC check), the reaction mixture is warmed to 0 ° C and the

Reaktionsgemisch mit einer gesättigten Ammoniumchlorid-Lösung. Man extrahierte zweimal mit Ethylacetat (ä 500 ml), terennt die Phasen und wäscht die vereinigten organischen Phasen über Natriumsulfat. Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch Säulenchromatographie (Gradient Essigester/Petrolether). 2-Cyclopropyl-l-(2,6- difluorphenyl)ethanon wurde in Form eines farblosen Öls isoliert (5,0 g, 39% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7.38 (m, 1H), 6.94 (m, 2H), 2.75 (d, 2H), 1.07 (m, 1H), 0.59 (m, 2H), 0.18 (m, 2H). Reaction mixture with a saturated ammonium chloride solution. It was extracted twice with ethyl acetate (a 500 ml), the phases are separated and the combined organic phases are washed over sodium sulfate. Then the solvent was removed in vacuo and the residue was purified by column chromatography (gradient ethyl acetate / petroleum ether). 2-Cyclopropyl-1- (2,6-difluorophenyl) ethanone was isolated as a colorless oil (5.0 g, 39% of theory). 'H-NMR (400 MHz, CDC1 3 δ, ppm) 7.38 (m, 1H), 6.94 (m, 2H), 2.75 (d, 2H), 1.07 (m, 1H), 0.59 (m, 2H), 0.18 (m, 2H).

Synthesestufe 3: (2E)-2-Cyclopropyl-l -(2,6-difluor henyl)-3-(dimethylamino)prop-2-en-l-on Synthesis Step 3: (2E) -2-Cyclopropyl-1- (2,6-difluorohexyl) -3- (dimethylamino) prop-2-en-1-one

Figure imgf000066_0001
Figure imgf000066_0001

2-Cyclopropyl-l-(2,6-difluorphenyl)ethanon (5,50 g, 28.03 mmol, 1.0 equiv) und 1 , 1 -Dimethoxy-N,N- dimethylmethanamin (14,85 ml, 112,13 mmol, 4 equiv) wurden in DMF (25 ml) gelöst und für 2h auf 150 °C erhitzt und anschließend im Vakuum eingeengt. Das Rohprodukt wurde ohne weitere 2-Cyclopropyl-1- (2,6-difluorophenyl) ethanone (5.50 g, 28.03 mmol, 1.0 equiv) and 1, 1-dimethoxy-N, N-dimethylmethanamine (14.85 mL, 112.13 mmol, 4 equiv) were dissolved in DMF (25 ml) and heated to 150 ° C for 2 h and then concentrated in vacuo. The crude product was without further

Aufreinigung in der nächsten Synthesestufe eingesetzt. 'H-NMR (400 MHz, CDCI3 δ, ppm) 7.25 (m, 2H), 6.87 (m, 2H), 3.19 (bs, 6H), 1.52 (m, 1H), 0.76 (m, 2H), 0.43 (m, 2H). Purification used in the next stage of the synthesis. 'H-NMR (400 MHz, CDCl3 δ, ppm) 7.25 (m, 2H), 6.87 (m, 2H), 3.19 (bs, 6H), 1.52 (m, 1H), 0.76 (m, 2H), 0.43 ( m, 2H).

Synthesestufe 4: 4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol Synthesis Stage 4: 4-Cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazole

Figure imgf000066_0002
Figure imgf000066_0002

(2E)-2-Cyclopropyl-l-(2,6-difluorphenyl)-3-(dimethylamino)prop-2-en-l -on (7,00 g, 27,86 mmol, 1,0 equiv) wurde in Ethanol (50 ml) gelöst, und mit Hydrazinhydrat (8,13 ml, 83,76 mmol, 3,0 equiv) versetzt. Das resultierende Reaktionsgemisch wurde 8 h auf eine Temperatur von 80 °C erhitzt. Nach dem Abkühlen auf Raumtemperatur entfernte man das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol in Form eines gelben Feststoffes isoliert werden (5,64 g, 91% der Theorie). 'H-NMR (400 MHz, CDC13 δ, ppm) 7,37 (m, 1H), 7.33 (s, 1H), 7.02 (m, 2H), 1.62 (m, 1H), 0.78 (m, 3H), 0.48 (m, 2H). (2E) -2-Cyclopropyl-1- (2,6-difluorophenyl) -3- (dimethylamino) prop-2-en-1-one (7.00 g, 27.86 mmol, 1.0 equiv.) Was added Ethanol (50 ml), and hydrazine hydrate (8.13 ml, 83.76 mmol, 3.0 equiv.) Was added. The resulting reaction mixture was heated to a temperature of 80 ° C for 8 hours. After cooling to room temperature, the solvent was removed in vacuo. By final purified by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product, 4-cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazole was isolated as a yellow solid (5.64 g, 91% of theory). 'H NMR (400 MHz, CDC1 3 δ, ppm) 7.37 (m, 1H), 7.33 (s, 1H), 7.02 (m, 2H), 1.62 (m, 1H), 0.78 (m, 3H) , 0.48 (m, 2H).

Synthesestufe 5 : Ethyl-2- [4-cyclopropyl-3 -(2,6-difluorphenyl)- 1 H-pyrazol- 1 -yl] -2-methylpropanoat Synthesis Step 5: Ethyl 2- [4-cyclopropyl-3 - (2,6-difluorophenyl) -1 H -pyrazol-1-yl] -2-methylpropanoate

Figure imgf000067_0001
Figure imgf000067_0001

4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol (5,64 g, 25,61 mmol, 1,0 equiv), Ethyl-2-brom-2- methylpropanoat (4,70 ml, 32,01 mmol, 1,25 equiv) und Caesiumcarbonat (16,69 g, 51,22 mmol, 2,0 equiv) wurden in DMF (75 ml) gelöst und 2 h auf 100 °C erhitzt. Nach dem Abkühlen wurde das4-Cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazole (5.64 g, 25.61 mmol, 1.0 equiv), ethyl 2-bromo-2-methylpropanoate (4.70 mL, 32 , 01 mmol, 1.25 equiv) and cesium carbonate (16.69 g, 51.22 mmol, 2.0 equiv) were dissolved in DMF (75 ml) and heated at 100 ° C for 2 h. After cooling, the

Reaktionsgemisch in Wasser (100 ml) gegossen und dreimal mit jeweils 100 ml Ethylacetat extrahiert.The reaction mixture was poured into water (100 ml) and extracted three times with 100 ml of ethyl acetate each time.

Anschließend entfernte man das Lösungsmittel im Vakuum und reinigte den Rückstand durch Then the solvent was removed in vacuo and the residue was purified

Säulenchromatographie (Gradient Essigester/Heptan). Ethyl-2-[4-cyclopropyl-3-(2,6-difluorphenyl)- 1 H-pyrazol- 1-yl] -2-methylpropanoat wurde in Form eines gelben Öls isoliert (2,62 g, 30% der Theorie). Column chromatography (gradient ethyl acetate / heptane). Ethyl 2- [4-cyclopropyl-3- (2,6-difluorophenyl) -1 H -pyrazol-1-yl] -2-methylpropanoate was isolated as a yellow oil (2.62 g, 30% of theory). ,

'H-NMR (400 MHz, CDCI3 δ, ppm) 7.39 (m, 1H), 7.28 (s, 1H), 6.95 (m, 1H), 4.15 (q, 2H), 1.85 (s, 6H),'H-NMR (400 MHz, CDCl3 δ, ppm) 7.39 (m, 1H), 7.28 (s, 1H), 6.95 (m, 1H), 4.15 (q, 2H), 1.85 (s, 6H),

1.55 (m, 1H), 1.19 (t, 3H), 0.72 (m, 2H), 0.44 (m, 2H). 1.55 (m, 1H), 1.19 (t, 3H), 0.72 (m, 2H), 0.44 (m, 2H).

Synthesestufe 6 : 2- [4-Cyclopropyl-3 -(2,6-difluorphenyl)- 1 H-pyrazol- 1 -yl] -2-methylpropansäure Synthesis step 6: 2- [4-Cyclopropyl-3 - (2,6-difluorophenyl) -1 H -pyrazol-1-yl] -2-methylpropanoic acid

Figure imgf000067_0002
Figure imgf000067_0002

Ethyl-2-[4-cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropanoat (2,60 g, 7,78 mmol, 1,0 equiv) und Natriumhydroxid (467 mg, 11,66 mmol, 1,5 equiv) wurden in Ethanol (25 ml) und Wasser (25 ml) gelöst und 2 h bei Raumtemperatur gerührt. Man entfernt das Lösungsmittel im Vakuum nimmt den Rückstand in Wasser (50 ml) auf und säuert die Lösung mit Ethylacetat extrahiert. Die organische Phase trocknete man über Magnesiumsulfat und entfernte das Lösungsmittel im Vakuum. 2- [4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropansäure wurde in Form eines weißen Feststoffes isoliert (2,35 g, 95% der Theorie). 'H-NMR (400 MHz, DMSO-d6 δ, ppm) 7,38 (m, 1H), 7.34 (s, 1H), 7.01 (m, 2H), 1.78 (s, 6H), 1,60 (m, 1H), 0.79 (m, 2H), 0.45 (m, 2H). Synthesestufe 7 : 2-[4-Cyclopropyl-3-(2,6-difluorphenyl)- 1 H-pyrazol- 1 -yl] -2-methyl- 1 -(Pyrrolidin- 1 - yl)propan-l -on (1.169-101) Ethyl 2- [4-cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoate (2.60 g, 7.78 mmol, 1.0 equiv) and sodium hydroxide ( 467 mg, 11.66 mmol, 1.5 equiv) were dissolved in ethanol (25 ml) and water (25 ml) and stirred for 2 h at room temperature. The solvent is removed in vacuo, the residue is taken up in water (50 ml) and the solution is acidified with ethyl acetate. The organic phase was dried over magnesium sulfate and the solvent removed in vacuo. 2 [4-Cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoic acid was isolated as a white solid (2.35 g, 95% of theory). 'H-NMR (400 MHz, DMSO-d 6 δ, ppm) 7.38 (m, 1H), 7:34 (s, 1H), 7:01 (m, 2H), 1.78 (s, 6H), 1.60 ( m, 1H), 0.79 (m, 2H), 0.45 (m, 2H). Synthesis Step 7: 2- [4-Cyclopropyl-3- (2,6-difluorophenyl) -1 H -pyrazol-1-yl] -2-methyl-1- (pyrrolidin-1-yl) propan-1-one (1.169 -101)

Figure imgf000068_0001
2-[4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2-methylpropansäure (200 mg, 0,65 mmol, 1,0 equiv), 2,4,6-Tripropyl-l,3,5,2,4,6-trioxatriphosphinan-2,4,6-trioxid (T3P, 583 μΐ, 0,98 mmol, 1,50 equiv.; 50%>ig in THF), Triethylamin (319 μΐ, 2,29 mmol, 3,5 equiv.) und Pyrrolidin (65 μΐ, 0,78 mmol, 1,2 equiv.) wurden in Dichlormethan (5 ml) gelöst und 16 h bei Raumtemperatur gerührt. Danach verdünnte man das Reaktionsgemisch mit gesättigter Natriumhydrogencarbonat-Lösung (5 ml) und extrahierte danach mit Dichlormethan (10 ml). Die wässrige Phase wurde dreimal mit Dichlormethan extrahiert (10 ml) und die Phasen über einen Phasenseparator getrennt. Man entfernte das Lösungsmittel im Vakuum. Durch abschließende säulenchromatographische Reinigung (Gradient Essigester/Heptan) des resultierenden Rohproduktes konnte 2-[4-Cyclopropyl-3-(2,6-difluorphenyl)-lH-pyrazol-l-yl]-2- methyl-1 -(Pyrrolidin- l-yl)propan-l-on in Form eines weißen Feststoffes isoliert werden (184 mg, 77%> der Theorie). 'H-NMR (400 MHz, DMSO-d6 δ, ppm) 7.32 (m, 1H), 7.21 (s, 1H), 6.96 (m, 2H), 3.51 (m, 2H), 2.57 (m, 2H), 1.81 (s, 6H), 1.71 (m, 4H), 1.51(m, 1H), 0.75 (m, 2H), 0.41 (m, 2H).
Figure imgf000068_0001
2- [4-Cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methylpropanoic acid (200 mg, 0.65 mmol, 1.0 equiv.), 2,4,6- Tripropyl-l, 3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide (T3P, 583 μΐ, 0.98 mmol, 1.50 equiv; 50% in THF), triethylamine ( 319 μΐ, 2.29 mmol, 3.5 equiv.) And pyrrolidine (65 μΐ, 0.78 mmol, 1.2 equiv.) Were dissolved in dichloromethane (5 ml) and stirred at room temperature for 16 h. Thereafter, the reaction mixture was diluted with saturated sodium bicarbonate solution (5 ml) and then extracted with dichloromethane (10 ml). The aqueous phase was extracted three times with dichloromethane (10 ml) and the phases separated via a phase separator. The solvent was removed in vacuo. Final purification by column chromatography (gradient ethyl acetate / heptane) of the resulting crude product afforded 2- [4-cyclopropyl-3- (2,6-difluorophenyl) -1H-pyrazol-1-yl] -2-methyl-1 - (pyrrolidin-1 -yl) propan-1-one can be isolated as a white solid (184 mg, 77%> of theory). 'H-NMR (400 MHz, DMSO-d 6 δ, ppm) 7:32 (m, 1H), 7.21 (s, 1H), 6.96 (m, 2H), 3.51, (m, 2H), 2:57 (m, 2H) , 1.81 (s, 6H), 1.71 (m, 4H), 1.51 (m, 1H), 0.75 (m, 2H), 0.41 (m, 2H).

In Analogie zu den oben angeführten und an entsprechender Stelle rezitierten Herstellungsbeispielen und unter Berücksichtigung der allgemeinen Angaben zur Herstellung von substituierten Pyrazole erhält man die nachfolgend genannten Verbindungen: By analogy with the production examples recited above and recited at the appropriate place and taking into account the general information on the preparation of substituted pyrazoles, the following compounds are obtained:

Figure imgf000069_0001
Figure imgf000069_0001

Tabelle L I : Bevorzugte Verbindungen der Formel (L I) sind die Verbindungen 1.1-1 bis 1.1-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.1-1 bis 1.1- 400 der Tabelle LI sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table L I: Preferred compounds of the formula (L I) are the compounds 1.1-1 to 1.1-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.1-1 to 1.1-400 of Table LI are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Tabelle 1 : Table 1 :

No. Z  No. Z

1 Z-\ A 1 Z- \ A

2 Z-1.2  2 Z-1.2

3 Z-1.3  3 Z-1.3

4 Z-1.4  4 Z-1.4

5 Z-1.5  5 Z-1.5

6 Z-1.6  6 Z-1.6

7 Z-1.7  7 Z-1.7

8 Z-1.8  8 Z-1.8

9 Z-1.9  9 Z-1.9

10 Z-1.10  10 Z-1.10

11 z-i.n  11 z-i.n

12 Z-1.12  12 Z-1.12

13 Z-1.13  13 Z-1.13

14 Z-1.14  14 Z-1.14

15 Z-1.15  15 Z-1.15

16 Z-1.16  16 Z-1.16

17 Z-1.17  17 Z-1.17

18 Z-1.18 No. Z 18 Z-1.18 No. Z

19 Z-1.1919 Z-1.19

20 Z-1.2020 Z-1.20

21 Z-1.2121 Z-1.21

22 Z-1.2222 Z-1.22

23 Z-1.2323 Z-1.23

24 Z-1.2424 Z-1.24

25 Z-1.2525 Z-1.25

26 Z-1.2626 Z-1.26

27 Z-1.2727 Z-1.27

28 Z-1.2828 Z-1.28

29 Z-1.2929 Z-1.29

30 Z-1.3030 Z-1.30

31 Z-1.3131 Z-1.31

32 Z-1.3232 Z-1.32

33 Z-1.3333 Z-1.33

34 Z-1.3434 Z-1.34

35 Z-1.3535 Z-1.35

36 Z-1.3636 Z-1.36

37 Z-1.3737 Z-1.37

38 Z-1.3838 Z-1.38

39 Z-1.3939 Z-1.39

40 Z-1.4040 Z-1.40

41 Z-1.4141 Z-1.41

42 Z-1.4242 Z-1.42

43 Z-1.4343 Z-1.43

44 Z-1.4444 Z-1.44

45 Z-1.4545 Z-1.45

46 Z-1.4646 Z-1.46

47 Z-1.4747 Z-1.47

48 Z-1.4848 Z-1.48

49 Z-1.4949 Z-1.49

50 Z-1.5050 Z-1.50

51 Z-1.5151 Z-1.51

52 Z-1.52 No. Z 52 Z-1.52 No. Z

53 Z-1.5353 Z-1.53

54 Z-1.5454 Z-1.54

55 Z-1.5555 Z-1.55

56 Z-1.5656 Z-1.56

57 Z-1.5757 Z-1.57

58 Z-1.5858 Z-1.58

59 Z-1.5959 Z-1.59

60 Z-1.6060 Z-1.60

61 Z-1.6161 Z-1.61

62 Z-1.6262 Z-1.62

63 Z-1.6363 Z-1.63

64 Z-1.6464 Z-1.64

65 Z-1.6565 Z-1.65

66 Z-1.6666 Z-1.66

67 Z-1.6767 Z-1.67

68 Z-1.6868 Z-1.68

69 Z-1.6969 Z-1.69

70 Z-1.7070 Z-1.70

71 Z-1.7171 Z-1.71

72 Z-1.7272 Z-1.72

73 Z-1.7373 Z-1.73

74 Z-1.7474 Z-1.74

75 Z-1.7575 Z-1.75

76 Z-1.7676 Z-1.76

77 Z-1.7777 Z-1.77

78 Z-1.7878 Z-1.78

79 Z-1.7979 Z-1.79

80 Z-1.8080 Z-1.80

81 Z-1.8181 Z-1.81

82 Z-1.8282 Z-1.82

83 Z-1.8383 Z-1.83

84 Z-1.8484 Z-1.84

85 Z-1.8585 Z-1.85

86 Z-1.86 No. z86 Z-1.86 No. z

87 Z-1.8787 Z-1.87

88 Z-1.8888 Z-1.88

89 Z-1.8989 Z-1.89

90 Z-1.9090 Z-1.90

91 Z-1.9191 Z-1.91

92 Z-1.9292 Z-1.92

93 Z-1.9393 Z-1.93

94 Z-1.9494 Z-1.94

95 Z-1.9595 Z-1.95

96 Z-1.9696 Z-1.96

97 Z-1.9797 Z-1.97

98 Z-1.9898 Z-1.98

99 Z-1.9999 Z-1.99

100 Z-1.100100 Z-1,100

101 Z-1.101101 Z-1.101

102 Z-1.102102 Z-1.102

103 Z-1.103103 Z-1.103

104 Z-1.104104 Z-1.104

105 Z-1.105105 Z-1.105

106 Z-1.106106 Z-1.106

107 Z-1.107107 Z-1.107

108 Z-1.108108 Z-1.108

109 Z-1.109109 Z-1.109

110 Z-1.110110 Z-1.110

111 Z-l . l l l111 Z-l. l l l

112 Z-1.112112 Z-1,112

113 Z-1.113113 Z-1,113

114 Z-1.114114 Z-1,114

115 Z-1.115115 Z-1,115

116 Z-1.116116 Z-1,116

117 Z-1.117117 Z-1,117

118 Z-1.118118 Z-1,118

119 Z-1.119119 Z-1.119

120 Z-1.120 No. Z 120 Z-1,120 No. Z

121 Z-1.121121 Z-1.121

122 Z-1.122122 Z-1.122

123 Z-1.123123 Z-1.123

124 Z-1.124124 Z-1.124

125 Z-1.125125 Z-1.125

126 Z-1.126126 Z-1.126

127 Z-1.127127 Z-1.127

128 Z-1.128128 Z-1.128

129 Z-1.129129 Z-1.129

130 Z-1.130130 Z-1,130

131 Z-1.131131 Z-1,131

132 Z-1.132132 Z-1,132

133 Z-1.133133 Z-1,133

134 Z-1.134134 Z-1,134

135 Z-1.135135 Z-1,135

136 Z-1.136136 Z-1,136

137 Z-1.137137 Z-1,137

138 Z-1.138138 Z-1,138

139 Z-1.139139 Z-1.139

140 Z-1.140140 Z-1,140

141 Z-1.141141 Z-1,141

142 Z-1.142142 Z-1,142

143 Z-1.143143 Z-1,143

144 Z-1.144144 Z-1,144

145 Z-1.145145 Z-1,145

146 Z-1.146146 Z-1,146

147 Z-1.147147 Z-1,147

148 Z-1.148148 Z-1,148

149 Z-1.149149 Z-1,149

150 Z-1.150150 Z-1,150

151 Z-1.151151 Z-1,151

152 Z-1.152152 Z-1,152

153 Z-1.153153 Z-1,153

154 Z-1.154 No. Z 154 Z-1,154 No. Z

155 Z-1.155155 Z-1,155

156 Z-1.156156 Z-1,156

157 Z-1.157157 Z-1,157

158 Z-1.158158 Z-1,158

159 Z-1.159159 Z-1.159

160 Z-1.160160 Z-1,160

161 Z-1.161161 Z-1.161

162 Z-1.162162 Z-1,162

163 Z-1.163163 Z-1.163

164 Z-1.164164 Z-1.164

165 Z-1.165165 Z-1,165

166 Z-1.166166 Z-1.166

167 Z-1.167167 Z-1.167

168 Z-1.168168 Z-1.168

169 Z-1.169169 Z-1.169

170 Z-1.170170 Z-1,170

171 Z-1.171171 Z-1,171

172 Z-1.172172 Z-1,172

173 Z-1.173173 Z-1,173

174 Z-1.174174 Z-1,174

175 Z-1.175175 Z-1,175

176 Z-1.176176 Z-1,176

177 Z-1.177177 Z-1,177

178 Z-1.178178 Z-1.178

179 Z-1.179179 Z-1.179

180 Z-1.180180 Z-1,180

181 Z-1.181181 Z-1,181

182 Z-1.182182 Z-1,182

183 Z-1.183183 Z-1,183

184 Z-1.184184 Z-1,184

185 Z-1.185185 Z-1,185

186 Z-1.186186 Z-1,186

187 Z-1187187 Z-1187

188 Z-1.188 No. Z 188 Z-1,188 No. Z

189 Z-1.189189 Z-1,189

190 Z-1.190190 Z-1.190

191 Z-1.191191 Z-1.191

192 Z-1.192192 Z-1.192

193 Z-1.193193 Z-1.193

194 Z-1.194194 Z-1,194

195 Z-1.195195 Z-1.195

196 Z-1.196196 Z-1,196

197 Z-1.197197 Z-1,197

198 Z-1.198198 Z-1,198

199 Z-1.199199 Z-1.199

200 Z-1.200200 Z-1,200

201 Z-1.201201 Z-1.201

202 Z-1. 202202 Z-1. 202

203 Z-1. 203203 Z-1. 203

204 Z-1. 204204 Z-1. 204

205 Z-1. 205205 Z-1. 205

206 Z-1. 206206 Z-1. 206

207 Z-1. 207207 Z-1. 207

208 Z-1. 208208 Z-1. 208

209 Z-1. 209209 Z-1. 209

210 Z-1.210210 Z-1.210

211 Z-1. 211211 Z-1. 211

212 Z-1. 212212 Z-1. 212

213 Z-1. 213213 Z-1. 213

214 Z-1. 214214 Z-1. 214

215 Z-1. 215215 Z-1. 215

216 Z-1. 216216 Z-1. 216

217 Z-1. 217217 Z-1. 217

218 Z-1. 218218 Z-1. 218

219 Z-1. 219219 Z-1. 219

220 Z-1. 220220 Z-1. 220

221 Z-1.221221 Z-1.221

222 Z-1.222 No. Z 222 Z-1.222 No. Z

223 Z-1.223223 Z-1.223

-224 Z- 1.224-224 Z- 1,224

225 Z-1.225225 Z-1,225

226 Z-1.226226 Z-1.226

227 Z-1.227227 Z-1.227

228 Z-1.228228 Z-1.228

229 Z-1.229229 Z-1.229

230 Z-1.230230 Z-1,230

231 Z-1.231231 Z-1,231

232 Z-1.232232 Z-1.232

233 Z-1.233233 Z-1.233

234 Z-1.234234 Z-1,234

235 Z-1.235235 Z-1,235

236 Z-1.236236 Z-1,236

237 Z-1.237237 Z-1.237

238 Z-1.238238 Z-1.238

239 Z-1.239239 Z-1.239

240 Z- 1-240240 Z 1-240

241 Z-1.241241 Z-1.241

242 Z- 1.242242 Z-1.242

243 Z-1.243243 Z-1.243

244 Z- 1.244244 Z- 1.244

245 Z-1.245245 Z-1,245

246 Z-1.246246 Z-1.246

247 Z-1.247247 Z-1.247

248 Z-1.248248 Z-1.248

249 Z-1.249249 Z-1.249

250 Z-1.250250 Z-1,250

251 Z-1.251251 Z-1.251

252 Z-1.252252 Z-1.252

253 Z-1.253253 Z-1.253

254 Z-1.254254 Z-1.254

255 Z-1.255255 Z-1.255

256 Z-1.256256 Z-1.256

257 Z-1.257 No. Z 257 Z-1.257 No. Z

258 Z-1.258258 Z-1.258

259 Z-1.259259 Z-1.259

260 Z-1.260260 Z-1,260

261 Z-1.261261 Z-1.261

262 Z-1.262262 Z-1.262

263 Z-1.263263 Z-1.263

264 Z-1.264264 Z-1.264

265 Z-1.265265 Z-1,265

266 Z-1.266266 Z-1.266

267 Z-1.267267 Z-1.267

268 Z-1.268268 Z-1.268

269 Z-1.269269 Z-1.269

270 Z-1.270270 Z-1,270

271 Z-1.271271 Z-1.271

272 Z-1.272272 Z-1.272

273 Z-1.273273 Z-1.273

274 Z-1.274274 Z-1.274

275 Z-1.275275 Z-1.275

276 Z-1.276276 Z-1.276

277 Z-1.277277 Z-1.277

278 Z-1.278278 Z-1.278

279 Z-1.279279 Z-1.279

280 Z-1.280280 Z-1,280

281 Z-1.281281 Z-1.281

282 Z-1.282282 Z-1.282

283 Z-1.283283 Z-1.283

284 Z-1.284284 Z-1.284

285 Z-1.285285 Z-1.285

286 Z-1.286286 Z-1.286

287 Z-1.287287 Z-1.287

288 Z-1.288288 Z-1.288

289 Z-1.289289 Z-1.289

290 Z-1.290290 Z-1,290

291 Z-1.291 No. Z 291 Z-1.291 No. Z

292 Z-1.292292 Z-1.292

293 Z-1.293293 Z-1.293

294 Z-1.294294 Z-1.294

295 Z-1.295295 Z-1,295

296 Z-1.296296 Z-1.296

297 Z-1.297297 Z-1.297

298 Z-1.298298 Z-1.298

299 Z-1.299299 Z-1,299

300 Z-1.300300 Z-1.300

301 Z-1.301301 Z-1.301

302 Z-1.302302 Z-1.302

303 Z-1.303303 Z-1.303

304 Z-1.304304 Z-1.304

305 Z-1.305305 Z-1.305

306 Z-1.306306 Z-1.306

307 Z-1.307307 Z-1.307

308 Z-1.308308 Z-1.308

309 Z-1.309309 Z-1.309

310 Z-1.310310 Z-1.310

311 Z-1.311311 Z-1.311

312 Z-1.312312 Z-1.312

313 Z-1.313313 Z-1.313

314 Z-1.314314 Z-1.314

315 Z-1.315315 Z-1.315

316 Z-1.316316 Z-1.316

317 Z-1.317317 Z-1.317

318 Z-1.318318 Z-1.318

319 Z-1.319319 Z-1.319

320 Z-1.320320 Z-1.320

321 Z-1.321321 Z-1.321

322 Z-1.322322 Z-1.322

323 Z-1.323323 Z-1.323

324 Z-1.324324 Z-1.324

325 Z-1.325 No. Z 325 Z-1,325 No. Z

326 Z-1.326326 Z-1.326

327 Z-1.327327 Z-1.327

328 Z-1.328328 Z-1.328

329 Z-1.329329 Z-1.329

330 Z-1.330330 Z-1.330

331 Z-1.331331 Z-1.331

332 Z-1.332332 Z-1.332

333 Z-1.333333 Z-1.333

334 Z-1.334334 Z-1.334

335 Z-1.335335 Z-1.335

336 Z-1.336336 Z-1.336

337 Z-1.337337 Z-1.337

338 Z-1.338338 Z-1.338

339 Z-1.339339 Z-1.339

340 Z-1.340340 Z-1.340

341 Z-1.341341 Z-1.341

342 Z-1.342342 Z-1.342

343 Z-1.343343 Z-1.343

344 Z-1.344344 Z-1.344

345 Z-1.345345 Z-1.345

346 Z-1.346346 Z-1.346

347 Z-1.347347 Z-1.347

348 Z-1.348348 Z-1.348

349 Z-1.349349 Z-1.349

350 Z-1.350350 Z-1.350

351 Z-1.351351 Z-1.351

352 Z-1.352352 Z-1.352

353 Z-1.353353 Z-1.353

354 Z-1.354354 Z-1.354

355 Z-1.355355 Z-1.355

356 Z-1.356356 Z-1.356

357 Z-1.357357 Z-1.357

358 Z-1.358358 Z-1.358

359 Z-1.359 No. Z 359 Z-1.359 No. Z

360 Z-1.360360 Z-1.360

361 Z-1.361361 Z-1.361

362 Z-1.362362 Z-1.362

363 Z-1.363363 Z-1.363

364 Z-1.364364 Z-1.364

365 Z-1.365365 Z-1.365

366 Z-1.366366 Z-1.366

367 Z-1.367367 Z-1,367

368 Z-1.368368 Z-1.368

369 Z-1.369369 Z-1.369

370 Z-1.370370 Z-1.370

371 Z-1.371371 Z-1.371

372 Z-1.372372 Z-1.372

373 Z-1.373373 Z-1.373

374 Z-1.374374 Z-1.374

375 Z-1.375375 Z-1.375

376 Z-1.376376 Z-1.376

377 Z-1.377377 Z-1.377

378 Z-1.378378 Z-1.378

379 Z-1.379379 Z-1.379

380 Z-1.380380 Z-1.380

381 Z-1.381381 Z-1.381

382 Z-1.382382 Z-1.382

383 Z-1.383383 Z-1.383

384 Z-1.384384 Z-1.384

385 Z-1.385385 Z-1.385

386 Z-1.386386 Z-1.386

387 Z-1.387387 Z-1.387

388 Z-1.388388 Z-1.388

389 Z-1.389389 Z-1.389

390 Z-1.390390 Z-1.390

391 Z-1.391391 Z-1,391

392 Z-1.392392 Z-1.392

393 Z-1.393 No. Z 393 Z-1.393 No. Z

394 Z-1.394 394 Z-1.394

395 Z-1.395  395 Z-1.395

396 Z-1.396  396 Z-1,396

397 Z-1.397  397 Z-1,397

398 Z-1.398  398 Z-1.398

399 Z-1.399  399 Z-1.399

400 Z-1.400  400 Z-1,400

Figure imgf000081_0001
Figure imgf000081_0001

Tabelle 1.2: Bevorzugte Verbindungen der Formel (1.2) sind die Verbindungen 1.2-1 bis 1.2-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.2-1 bis 1.2- 400 der Tabelle 1.2 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.2: Preferred compounds of the formula (1.2) are the compounds 1.2-1 to 1.2-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.2-1 to 1.2- 400 of Table 1.2 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000081_0002
Tabelle 1.3: Bevorzugte Verbindungen der Formel (1.3) sind die Verbindungen 1.3-1 bis 1.3-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.3-1 bis 1.3- 400 der Tabelle 1.3 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000081_0002
Table 1.3: Preferred compounds of the formula (1.3) are the compounds 1.3-1 to 1.3-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.3-1 to 1.3-400 of Table 1.3 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000082_0001
Figure imgf000082_0001

Tabelle 1.4: Bevorzugte Verbindungen der Formel (1.4) sind die Verbindungen 1.4-1 bis 1.4-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.4-1 bis 1.4- 400 der Tabelle 1.4 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.4: Preferred compounds of the formula (1.4) are the compounds 1.4-1 to 1.4-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.4-1 to 1.4-400 of Table 1.4 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000082_0002
Figure imgf000082_0002

Tabelle 1.5: Bevorzugte Verbindungen der Formel (1.5) sind die Verbindungen 1.5-1 bis 1.5-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.5-1 bis 1.5- 346 der Tabelle 1.5 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.5: Preferred compounds of the formula (1.5) are the compounds 1.5-1 to 1.5-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.5-1 to 1.5-346 of Table 1.5 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000083_0001
Figure imgf000083_0001

Tabelle 1.6: Bevorzugte Verbindungen der Formel (1.6) sind die Verbindungen 1.6-1 bis 1.6-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.6-1 bis 1.6- 400 der Tabelle 1.6 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.6: Preferred compounds of the formula (1.6) are the compounds 1.6-1 to 1.6-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.6-1 to 1.6-400 of Table 1.6 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000083_0002
Tabelle 1.7: Bevorzugte Verbindungen der Formel (1.7) sind die Verbindungen 1.7-1 bis 1.7-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.7-1 bis 1.7- 400 der Tabelle 1.7 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000083_0002
Table 1.7: Preferred compounds of the formula (1.7) are the compounds 1.7-1 to 1.7-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.7-1 to 1.7-400 of Table 1.7 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000084_0001
Figure imgf000084_0001

Tabelle 1.8: Bevorzugte Verbindungen der Formel (1.8) sind die Verbindungen 1.8-1 bis 1.8-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.8-1 bis 1.8- 400 der Tabelle 1.8 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.8: Preferred compounds of the formula (1.8) are the compounds 1.8-1 to 1.8-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.8-1 to 1.8-400 of Table 1.8 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000084_0002
Tabelle 1.9: Bevorzugte Verbindungen der Formel (1.9) sind die Verbindungen 1.9-1 bis 1.9-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.9-1 bis 1.9- 400 der Tabelle 1.9 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000084_0002
Table 1.9: Preferred compounds of the formula (1.9) are the compounds 1.9-1 to 1.9-400, wherein Z has the meaning given in the respective line of Table 1. The compounds 1.9-1 to 1.9-400 of Table 1.9 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000085_0001
Figure imgf000085_0001

Tabelle 1.10: Bevorzugte Verbindungen der Formel (1.10) sind die Verbindungen 1.10-1 bis 1.10-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.10-1 bis 1.10-400 der Tabelle 1.10 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.10: Preferred compounds of the formula (1.10) are the compounds 1.10-1 to 1.10-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.10-1 to 1.10-400 of Table 1.10 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000085_0002
Tabelle 1.11 : Bevorzugte Verbindungen der Formel (1.11) sind die Verbindungen 1.11 - 1 bis 1.11 -400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen L I 1-1 bis L I 1-400 der Tabelle LI 1 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000086_0001
Figure imgf000085_0002
Table 1.11: Preferred compounds of the formula (1.11) are the compounds 1.11 - 1 to 1.11 -400, in which Z has the meanings of Table 1 given in the respective line. The compounds LI 1-1 to LI 1-400 of Table LI 1 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000086_0001

Tabelle 1.12: Bevorzugte Verbindungen der Formel (1.12) sind die Verbindungen 1.12-1 bis 1.12-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.12-1 bis 1.12-400 der Tabelle 1.12 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.12: Preferred compounds of the formula (1.12) are the compounds 1.12-1 to 1.12-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.12-1 to 1.12-400 of Table 1.12 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000086_0002
Tabelle 1.13: Bevorzugte Verbindungen der Formel (1.13) sind die Verbindungen 1.13-1 bis 1.13-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.13-1 bis 1.13-400 der Tabelle 1.13 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000087_0001
Figure imgf000086_0002
Table 1.13: Preferred compounds of the formula (1.13) are the compounds 1.13-1 to 1.13-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.13-1 to 1.13-400 of Table 1.13 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000087_0001

Tabelle 1.14: Bevorzugte Verbindungen der Formel (1.14) sind die Verbindungen 1.14-1 bis 1.14-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.14-1 bis 1.14-400 der Tabelle 1.14 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.14: Preferred compounds of the formula (1.14) are the compounds 1.14-1 to 1.14-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.14-1 to 1.14-400 of Table 1.14 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000087_0002
Tabelle 1.15: Bevorzugte Verbindungen der Formel (1.15) sind die Verbindungen 1.15-1 bis 1.15-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.15-1 bis 1.15-400 der Tabelle 1.15 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000088_0001
Figure imgf000087_0002
Table 1.15: Preferred compounds of the formula (1.15) are the compounds 1.15-1 to 1.15-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.15-1 to 1.15-400 of Table 1.15 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000088_0001

Tabelle 1.16: Bevorzugte Verbindungen der Formel (1.16) sind die Verbindungen 1.16-1 bis 1.16-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.16-1 bis 1.16-400 der Tabelle 1.16 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.16: Preferred compounds of the formula (1.16) are the compounds 1.16-1 to 1.16-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.16-1 to 1.16-400 of Table 1.16 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000088_0002
Tabelle 1.17: Bevorzugte Verbindungen der Formel (1.17) sind die Verbindungen 1.17-1 bis 1.17-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.17-1 bis 1.17-400 der Tabelle 1.17 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000089_0001
Figure imgf000088_0002
Table 1.17: Preferred compounds of the formula (1.17) are the compounds 1.17-1 to 1.17-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.17-1 to 1.17-400 of Table 1.17 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000089_0001

Tabelle 1.18: Bevorzugte Verbindungen der Formel (1.18) sind die Verbindungen 1.18-1 bis 1.18-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.18-1 bis 1.18-400 der Tabelle 1.18 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.18: Preferred compounds of the formula (1.18) are the compounds 1.18-1 to 1.18-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.18-1 to 1.18-400 of Table 1.18 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000089_0002
Tabelle 1.19: Bevorzugte Verbindungen der Formel (1.19) sind die Verbindungen 1.19-1 bis 1.19-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.19-1 bis 1.19-400 der Tabelle 1.19 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000090_0001
Figure imgf000089_0002
Table 1.19: Preferred compounds of the formula (1.19) are the compounds 1.19-1 to 1.19-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.19-1 to 1.19-400 of Table 1.19 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000090_0001

Tabelle 1.20: Bevorzugte Verbindungen der Formel (1.20) sind die Verbindungen 1.20-1 bis 1.20-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.20-1 bis 1.20-400 der Tabelle 1.20 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.20: Preferred compounds of the formula (1.20) are the compounds 1.20-1 to 1.20-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.20-1 to 1.20-400 of Table 1.20 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000090_0002
Tabelle 1.21 : Bevorzugte Verbindungen der Formel (1.21) sind die Verbindungen 1.21 - 1 bis 1.21 -400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.21-1 bis 1.21-400 der Tabelle 1.21 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000091_0001
Figure imgf000090_0002
Table 1.21: Preferred compounds of the formula (1.21) are the compounds 1.21-1 to 1.21 -400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.21-1 to 1.21-400 of Table 1.21 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000091_0001

Tabelle 1.22: Bevorzugte Verbindungen der Formel (1.22) sind die Verbindungen 1.22-1 bis 1.22-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.22-1 bis 1.22-400 der Tabelle 1.22 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.22: Preferred compounds of the formula (1.22) are the compounds 1.22-1 to 1.22-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.22-1 to 1.22-400 of Table 1.22 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000091_0002
Tabelle 1.23: Bevorzugte Verbindungen der Formel (1.23) sind die Verbindungen 1.23-1 bis 1.23-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.23-1 bis 1.23-400 der Tabelle 1.23 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000092_0001
Figure imgf000091_0002
Table 1.23: Preferred compounds of the formula (1.23) are the compounds 1.23-1 to 1.23-400, in which Z has the meanings given in Table 1 in the respective line. The compounds 1.23-1 to 1.23-400 of Table 1.23 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000092_0001

Tabelle 1.24: Bevorzugte Verbindungen der Formel (1.24) sind die Verbindungen 1.24-1 bis 1.24-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.24-1 bis 1.24-400 der Tabelle 1.24 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.24: Preferred compounds of the formula (1.24) are the compounds 1.24-1 to 1.24-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.24-1 to 1.24-400 of Table 1.24 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000092_0002
Tabelle 1.25: Bevorzugte Verbindungen der Formel (1.25) sind die Verbindungen 1.25-1 bis 1.25-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.25-1 bis 1.25-400 der Tabelle 1.25 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000093_0001
Figure imgf000092_0002
Table 1.25: Preferred compounds of the formula (1.25) are the compounds 1.25-1 to 1.25-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.25-1 to 1.25-400 of Table 1.25 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000093_0001

Tabelle 1.26: Bevorzugte Verbindungen der Formel (1.26) sind die Verbindungen 1.26-1 bis 1.26-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.26-1 bis 1.26-400 der Tabelle 1.26 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.26: Preferred compounds of the formula (1.26) are the compounds 1.26-1 to 1.26-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.26-1 to 1.26-400 of Table 1.26 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000093_0002
Tabelle 1.27: Bevorzugte Verbindungen der Formel (1.27) sind die Verbindungen 1.27-1 bis 1.27-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.27-1 bis 1.27-400 der Tabelle 1.27 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000094_0001
Figure imgf000093_0002
Table 1.27: Preferred compounds of the formula (1.27) are the compounds 1.27-1 to 1.27-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.27-1 to 1.27-400 of Table 1.27 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000094_0001

Tabelle 1.28: Bevorzugte Verbindungen der Formel (1.28) sind die Verbindungen 1.28-1 bis 1.28-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.28-1 bis 1.28-400 der Tabelle 1.28 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.28: Preferred compounds of the formula (1.28) are the compounds 1.28-1 to 1.28-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.28-1 to 1.28-400 of Table 1.28 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000094_0002
Tabelle 1.29: Bevorzugte Verbindungen der Formel (1.29) sind die Verbindungen 1.29-1 bis 1.29-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.29-1 bis 1.29-400 der Tabelle 1.29 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000095_0001
Figure imgf000094_0002
Table 1.29: Preferred compounds of the formula (1.29) are the compounds 1.29-1 to 1.29-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.29-1 to 1.29-400 of Table 1.29 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000095_0001

Tabelle 1.30: Bevorzugte Verbindungen der Formel (1.30) sind die Verbindungen 1.30-1 bis 1.30-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.30-1 bis 1.30-400 der Tabelle 1.30 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.30: Preferred compounds of the formula (1.30) are the compounds 1.30-1 to 1.30-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.30-1 to 1.30-400 of Table 1.30 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000095_0002
Tabelle 1.31 : Bevorzugte Verbindungen der Formel (1.31) sind die Verbindungen 1.31-1 bis 1.31-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.31-1 bis 1.31-400 der Tabelle 1.31 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000096_0001
Figure imgf000095_0002
Table 1.31: Preferred compounds of the formula (1.31) are the compounds 1.31-1 to 1.31-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.31-1 to 1.31-400 of Table 1.31 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000096_0001

Tabelle 1.32: Bevorzugte Verbindungen der Formel (1.32) sind die Verbindungen 1.32-1 bis 1.32-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.32-1 bis 1.32-400 der Tabelle 1.32 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.32: Preferred compounds of the formula (1.32) are the compounds 1.32-1 to 1.32-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.32-1 to 1.32-400 of Table 1.32 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000096_0002
Tabelle 1.33: Bevorzugte Verbindungen der Formel (1.33) sind die Verbindungen 1.33-1 bis 1.33-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.33-1 bis 1.33-400 der Tabelle 1.33 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000097_0001
Figure imgf000096_0002
Table 1.33: Preferred compounds of the formula (1.33) are the compounds 1.33-1 to 1.33-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.33-1 to 1.33-400 of Table 1.33 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000097_0001

Tabelle 1.34: Bevorzugte Verbindungen der Formel (1.34) sind die Verbindungen 1.34-1 bis 1.34-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.34-1 bis 1.34-400 der Tabelle 1.34 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.34: Preferred compounds of the formula (1.34) are the compounds 1.34-1 to 1.34-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.34-1 to 1.34-400 of Table 1.34 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000097_0002
Tabelle 1.35: Bevorzugte Verbindungen der Formel (1.35) sind die Verbindungen 1.35-1 bis 1.35-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.35-1 bis 1.35-400 der Tabelle 1.35 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000098_0001
Figure imgf000097_0002
Table 1.35: Preferred compounds of the formula (1.35) are the compounds 1.35-1 to 1.35-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.35-1 to 1.35-400 of Table 1.35 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000098_0001

Tabelle 1.36: Bevorzugte Verbindungen der Formel (1.36) sind die Verbindungen 1.36-1 bis 1.36-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.36-1 bis 1.36-400 der Tabelle 1.36 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.36: Preferred compounds of the formula (1.36) are the compounds 1.36-1 to 1.36-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.36-1 to 1.36-400 of Table 1.36 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000098_0002
Tabelle 1.37: Bevorzugte Verbindungen der Formel (1.37) sind die Verbindungen 1.37-1 bis 1.37-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.37-1 bis 1.37-400 der Tabelle 1.37 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000099_0001
Figure imgf000098_0002
Table 1.37: Preferred compounds of the formula (1.37) are the compounds 1.37-1 to 1.37-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.37-1 to 1.37-400 of Table 1.37 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000099_0001

Tabelle 1.38: Bevorzugte Verbindungen der Formel (1.38) sind die Verbindungen 1.38-1 bis 1.38-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.38-1 bis 1.38-400 der Tabelle 1.38 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.38: Preferred compounds of the formula (1.38) are the compounds 1.38-1 to 1.38-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.38-1 to 1.38-400 of Table 1.38 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000099_0002
Tabelle 1.39: Bevorzugte Verbindungen der Formel (1.39) sind die Verbindungen 1.39-1 bis 1.39-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.39-1 bis 1.39-400 der Tabelle 1.39 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000100_0001
Figure imgf000099_0002
Table 1.39: Preferred compounds of the formula (1.39) are the compounds 1.39-1 to 1.39-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.39-1 to 1.39-400 of Table 1.39 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000100_0001

Tabelle 1.40: Bevorzugte Verbindungen der Formel (1.40) sind die Verbindungen 1.40-1 bis 1.40-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.40-1 bis 1.40-400 der Tabelle 1.40 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.40: Preferred compounds of the formula (1.40) are the compounds 1.40-1 to 1.40-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.40-1 to 1.40-400 of Table 1.40 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000100_0002
Tabelle 1.41 : Bevorzugte Verbindungen der Formel (1.41) sind die Verbindungen 1.41-1 bis 1.41-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.41-1 bis 1.41-400 der Tabelle 1.41 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000101_0001
Figure imgf000100_0002
Table 1.41: Preferred compounds of the formula (1.41) are the compounds 1.41-1 to 1.41-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.41-1 to 1.41-400 of Table 1.41 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000101_0001

Tabelle 1.42: Bevorzugte Verbindungen der Formel (1.42) sind die Verbindungen 1.42-1 bis 1.42-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.42-1 bis 1.42-400 der Tabelle 1.42 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.42: Preferred compounds of the formula (1.42) are the compounds 1.42-1 to 1.42-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.42-1 to 1.42-400 of Table 1.42 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000101_0002
Tabelle 1.43: Bevorzugte Verbindungen der Formel (1.43) sind die Verbindungen 1.43-1 bis 1.43-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.43-1 bis 1.43-400 der Tabelle 1.43 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000102_0001
Figure imgf000101_0002
Table 1.43: Preferred compounds of the formula (1.43) are the compounds 1.43-1 to 1.43-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.43-1 to 1.43-400 of Table 1.43 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000102_0001

Tabelle 1.44: Bevorzugte Verbindungen der Formel (1.44) sind die Verbindungen 1.44-1 bis 1.44-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.44-1 bis 1.44-400 der Tabelle 1.44 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.44: Preferred compounds of the formula (1.44) are the compounds 1.44-1 to 1.44-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.44-1 to 1.44-400 of Table 1.44 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000102_0002
Tabelle 1.45: Bevorzugte Verbindungen der Formel (1.45) sind die Verbindungen 1.45-1 bis 1.45-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.45-1 bis 1.45-400 der Tabelle 1.45 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000103_0001
Figure imgf000102_0002
Table 1.45: Preferred compounds of the formula (1.45) are the compounds 1.45-1 to 1.45-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.45-1 to 1.45-400 of Table 1.45 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000103_0001

Tabelle 1.46: Bevorzugte Verbindungen der Formel (1.46) sind die Verbindungen 1.46-1 bis 1.46-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.46-1 bis 1.46-400 der Tabelle 1.46 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.46: Preferred compounds of the formula (1.46) are the compounds 1.46-1 to 1.46-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.46-1 to 1.46-400 of Table 1.46 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000103_0002
Tabelle 1.47: Bevorzugte Verbindungen der Formel (1.47) sind die Verbindungen 1.47-1 bis 1.47-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.47-1 bis 1.47-400 der Tabelle 1.47 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000104_0001
Figure imgf000103_0002
Table 1.47: Preferred compounds of the formula (1.47) are the compounds 1.47-1 to 1.47-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.47-1 to 1.47-400 of Table 1.47 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000104_0001

Tabelle 1.48: Bevorzugte Verbindungen der Formel (1.48) sind die Verbindungen 1.48-1 bis 1.48-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.48-1 bis 1.48-400 der Tabelle 1.48 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.48: Preferred compounds of the formula (1.48) are the compounds 1.48-1 to 1.48-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.48-1 to 1.48-400 of Table 1.48 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000104_0002
Figure imgf000104_0002

Tabelle 1.49: Bevorzugte Verbindungen der Formel (1.49) sind die Verbindungen 1.49-1 bis 1.49-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.49-1 bis 1.49-400 der Tabelle 1.49 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000105_0001
Table 1.49: Preferred compounds of the formula (1.49) are the compounds 1.49-1 to 1.49-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.49-1 to 1.49-400 of Table 1.49 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000105_0001

Tabelle 1.50: Bevorzugte Verbindungen der Formel (1.50) sind die Verbindungen 1.50-1 bis 1.50-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.50-1 bis 1.50-400 der Tabelle 1.50 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.50: Preferred compounds of the formula (1.50) are the compounds 1.50-1 to 1.50-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.50-1 to 1.50-400 of Table 1.50 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000105_0002
Tabelle 1.51 : Bevorzugte Verbindungen der Formel (1.51) sind die Verbindungen 1.51-1 bis 1.51-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.51-1 bis 1.51-400 der Tabelle 1.51 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000106_0001
Figure imgf000105_0002
Table 1.51: Preferred compounds of the formula (1.51) are the compounds 1.51-1 to 1.51-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.51-1 to 1.51-400 of Table 1.51 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000106_0001

Tabelle 1.52: Bevorzugte Verbindungen der Formel (1.52) sind die Verbindungen 1.52-1 bis 1.52-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.52-1 bis 1.52-400 der Tabelle 1.52 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.52: Preferred compounds of the formula (1.52) are the compounds 1.52-1 to 1.52-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.52-1 to 1.52-400 of Table 1.52 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000106_0002
Tabelle 1.53: Bevorzugte Verbindungen der Formel (1.53) sind die Verbindungen 1.53-1 bis 1.53-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.53-1 bis 1.53-400 der Tabelle 1.53 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000107_0001
Figure imgf000106_0002
Table 1.53: Preferred compounds of the formula (1.53) are the compounds 1.53-1 to 1.53-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.53-1 to 1.53-400 of Table 1.53 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000107_0001

Tabelle 1.54: Bevorzugte Verbindungen der Formel (1.54) sind die Verbindungen 1.54-1 bis 1.54-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.54-1 bis 1.54-400 der Tabelle 1.54 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.54: Preferred compounds of the formula (1.54) are the compounds 1.54-1 to 1.54-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.54-1 to 1.54-400 of Table 1.54 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000107_0002
Tabelle 1.55: Bevorzugte Verbindungen der Formel (1.55) sind die Verbindungen 1.1-55 bis I. 55-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.55-1 bis 1.55-400 der Tabelle 1.55 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000108_0001
Figure imgf000107_0002
Table 1.55: Preferred compounds of the formula (1.55) are the compounds 1.1-55 to I. 55-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.55-1 to 1.55-400 of Table 1.55 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000108_0001

Tabelle 1.56: Bevorzugte Verbindungen der Formel (1.56) sind die Verbindungen 1.56-1 bis 1.56-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.56-1 bis 1.56-400 der Tabelle 1.56 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.56: Preferred compounds of the formula (1.56) are the compounds 1.56-1 to 1.56-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.56-1 to 1.56-400 of Table 1.56 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000108_0002
Tabelle 1.57: Bevorzugte Verbindungen der Formel (1.57) sind die Verbindungen 1.57-1 bis 1.57-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.57-1 bis 1.57-400 der Tabelle 1.57 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000109_0001
Figure imgf000108_0002
Table 1.57: Preferred compounds of the formula (1.57) are the compounds 1.57-1 to 1.57-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.57-1 to 1.57-400 of Table 1.57 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000109_0001

Tabelle 1.58: Bevorzugte Verbindungen der Formel (1.58) sind die Verbindungen 1.58-1 bis 1.58-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.58-1 bis 1.58-400 der Tabelle 1.58 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.58: Preferred compounds of the formula (1.58) are the compounds 1.58-1 to 1.58-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.58-1 to 1.58-400 of Table 1.58 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000109_0002
Tabelle 1.59: Bevorzugte Verbindungen der Formel (1.59) sind die Verbindungen 1.59-1 bis 1.59-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.59-1 bis 1.59-346 der Tabelle 1.59 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000110_0001
Figure imgf000109_0002
Table 1.59: Preferred compounds of the formula (1.59) are the compounds 1.59-1 to 1.59-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.59-1 to 1.59-346 of Table 1.59 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000110_0001

Tabelle 1.60: Bevorzugte Verbindungen der Formel (1.60) sind die Verbindungen 1.60-1 bis 1.60-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.60-1 bis 1.60-400 der Tabelle 1.60 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.60: Preferred compounds of the formula (1.60) are the compounds 1.60-1 to 1.60-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.60-1 to 1.60-400 of Table 1.60 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000110_0002
Tabelle 1.61 : Bevorzugte Verbindungen der Formel (1.61) sind die Verbindungen 1.61-1 bis 1.61-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.61-1 bis 1.61-400 der Tabelle 1.61 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000111_0001
Figure imgf000110_0002
Table 1.61: Preferred compounds of the formula (1.61) are the compounds 1.61-1 to 1.61-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.61-1 to 1.61-400 of Table 1.61 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000111_0001

Tabelle 1.62: Bevorzugte Verbindungen der Formel (1.62) sind die Verbindungen 1.62-1 bis 1.62-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.62-1 bis 1.62-400 der Tabelle 1.62 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.62: Preferred compounds of the formula (1.62) are the compounds 1.62-1 to 1.62-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.62-1 to 1.62-400 of Table 1.62 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000111_0002
Tabelle 1.63: Bevorzugte Verbindungen der Formel (1.63) sind die Verbindungen 1.63-1 bis 1.63-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.63-1 bis 1.63-400 der Tabelle 1.63 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000112_0001
Figure imgf000111_0002
Table 1.63: Preferred compounds of the formula (1.63) are the compounds 1.63-1 to 1.63-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.63-1 to 1.63-400 of Table 1.63 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000112_0001

Tabelle 1.64: Bevorzugte Verbindungen der Formel (1.64) sind die Verbindungen 1.64-1 bis 1.64-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.64-1 bis 1.64-400 der Tabelle 1.64 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.64: Preferred compounds of the formula (1.64) are the compounds 1.64-1 to 1.64-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.64-1 to 1.64-400 of Table 1.64 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000112_0002
Tabelle 1.65: Bevorzugte Verbindungen der Formel (1.65) sind die Verbindungen 1.1-65 bis I 65-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.65-1 bis 1.65-400 der Tabelle 1.65 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000113_0001
Figure imgf000112_0002
Table 1.65: Preferred compounds of the formula (1.65) are the compounds 1.1-65 to I 65-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.65-1 to 1.65-400 of Table 1.65 are thus affected by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000113_0001

Tabelle 1.66: Bevorzugte Verbindungen der Formel (1.66) sind die Verbindungen 1.66-1 bis 1.66-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.66-1 bis 1.66-400 der Tabelle 1.66 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.66: Preferred compounds of the formula (1.66) are the compounds 1.66-1 to 1.66-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.66-1 to 1.66-400 of Table 1.66 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000113_0002
Tabelle 1.67: Bevorzugte Verbindungen der Formel (1.67) sind die Verbindungen 1.67-1 bis 1.67-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.67-1 bis 1.67-400 der Tabelle 1.67 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000114_0001
Figure imgf000113_0002
Table 1.67: Preferred compounds of the formula (1.67) are the compounds 1.67-1 to 1.67-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.67-1 to 1.67-400 of Table 1.67 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000114_0001

Tabelle 1.68: Bevorzugte Verbindungen der Formel (1.68) sind die Verbindungen 1.68-1 bis 1.68-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.68-1 bis 1.68-400 der Tabelle 1.68 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.68: Preferred compounds of the formula (1.68) are the compounds 1.68-1 to 1.68-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.68-1 to 1.68-400 of Table 1.68 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000114_0002
Tabelle 1.69: Bevorzugte Verbindungen der Formel (1.69) sind die Verbindungen 1.69-1 bis 1.69-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.69-1 bis 1.69-346 der Tabelle 1.69 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000115_0001
Figure imgf000114_0002
Table 1.69: Preferred compounds of the formula (1.69) are the compounds 1.69-1 to 1.69-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.69-1 to 1.69-346 of Table 1.69 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000115_0001

Tabelle 1.70: Bevorzugte Verbindungen der Formel (1.70) sind die Verbindungen 1.70-1 bis 1.70-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.70-1 bis 1.70-400 der Tabelle 1.70 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.70: Preferred compounds of the formula (1.70) are the compounds 1.70-1 to 1.70-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.70-1 to 1.70-400 of Table 1.70 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000115_0002
Tabelle 1.71 : Bevorzugte Verbindungen der Formel (1.71) sind die Verbindungen 1.71-1 bis 1.71-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.71-1 bis 1.71-400 der Tabelle 1.71 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000116_0001
Figure imgf000115_0002
Table 1.71: Preferred compounds of the formula (1.71) are the compounds 1.71-1 to 1.71-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.71-1 to 1.71-400 of Table 1.71 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000116_0001

Tabelle 1.72: Bevorzugte Verbindungen der Formel (1.72) sind die Verbindungen 1.72-1 bis 1.72-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.72-1 bis 1.72-400 der Tabelle 1.72 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert, Table 1.72: Preferred compounds of the formula (1.72) are the compounds 1.72-1 to 1.72-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.72-1 to 1.72-400 of Table 1.72 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above,

ausgenommen der nachfolgend genannten Verbindung: except for the following compound:

2-[3-(2-Fluorphenyl)-4-methyl-lH-pyrazol-l-yl]-N,N,2-trimethylpropanamid CAS [63687-70-7]  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide CAS [63687-70-7]

Figure imgf000116_0002
Figure imgf000116_0002

Tabelle 1.73: Bevorzugte Verbindungen der Formel (1.73) sind die Verbindungen 1.73-1 bis 1.73-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.73-1 bis 1.73-400 der Tabelle 1.73 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.73: Preferred compounds of the formula (1.73) are the compounds 1.73-1 to 1.73-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.73-1 to 1.73-400 of Table 1.73 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000117_0001
Figure imgf000117_0001

Tabelle 1.74: Bevorzugte Verbindungen der Formel (1.74) sind die Verbindungen 1.74-1 bis 1.74-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.74-1 bis 1.74-400 der Tabelle 1.74 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.74: Preferred compounds of the formula (1.74) are the compounds 1.74-1 to 1.74-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.74-1 to 1.74-400 of Table 1.74 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000117_0002
Tabelle 1.75: Bevorzugte Verbindungen der Formel (1.75) sind die Verbindungen 1.1-75 bis I 75-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.75-1 bis 1.75-400 der Tabelle 1.75 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000118_0001
Figure imgf000117_0002
Table 1.75: Preferred compounds of the formula (1.75) are the compounds 1.1-75 to I 75-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.75-1 to 1.75-400 of Table 1.75 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000118_0001

Tabelle 1.76: Bevorzugte Verbindungen der Formel (1.76) sind die Verbindungen 1.76-1 bis 1.76-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.76-1 bis 1.76-400 der Tabelle 1.76 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.76: Preferred compounds of the formula (1.76) are the compounds 1.76-1 to 1.76-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.76-1 to 1.76-400 of Table 1.76 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000118_0002
Tabelle 1.77: Bevorzugte Verbindungen der Formel (1.77) sind die Verbindungen 1.77-1 bis 1.77-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.77-1 bis 1.77-400 der Tabelle 1.77 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000119_0001
Figure imgf000118_0002
Table 1.77: Preferred compounds of the formula (1.77) are the compounds 1.77-1 to 1.77-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.77-1 to 1.77-400 of Table 1.77 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000119_0001

Tabelle 1.78: Bevorzugte Verbindungen der Formel (1.78) sind die Verbindungen 1.78-1 bis 1.78-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.78-1 bis 1.78-400 der Tabelle 1.78 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.78: Preferred compounds of the formula (1.78) are the compounds 1.78-1 to 1.78-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.78-1 to 1.78-400 of Table 1.78 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000119_0002
Tabelle 1.79: Bevorzugte Verbindungen der Formel (1.79) sind die Verbindungen 1.79-1 bis 1.79-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.79-1 bis 1.79-346 der Tabelle 1.79 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000120_0001
Figure imgf000119_0002
Table 1.79: Preferred compounds of the formula (1.79) are the compounds 1.79-1 to 1.79-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.79-1 to 1.79-346 of Table 1.79 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000120_0001

Tabelle 1.80: Bevorzugte Verbindungen der Formel (1.80) sind die Verbindungen 1.80-1 bis 1.80-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.80-1 bis 1.80-400 der Tabelle 1.80 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.80: Preferred compounds of the formula (1.80) are the compounds 1.80-1 to 1.80-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.80-1 to 1.80-400 of Table 1.80 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000120_0002
Tabelle 1.81 : Bevorzugte Verbindungen der Formel (1.81) sind die Verbindungen 1.81-1 bis 1.81-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.81-1 bis 1.81-400 der Tabelle 1.81 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000121_0001
Figure imgf000120_0002
Table 1.81: Preferred compounds of the formula (1.81) are the compounds 1.81-1 to 1.81-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.81-1 to 1.81-400 of Table 1.81 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000121_0001

Tabelle 1.82: Bevorzugte Verbindungen der Formel (1.82) sind die Verbindungen 1.82-1 bis 1.82-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.82-1 bis 1.82-400 der Tabelle 1.82 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.82: Preferred compounds of the formula (1.82) are the compounds 1.82-1 to 1.82-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.82-1 to 1.82-400 of Table 1.82 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000121_0002
Tabelle 1.83: Bevorzugte Verbindungen der Formel (1.83) sind die Verbindungen 1.83-1 bis 1.83-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.83-1 bis 1.83-400 der Tabelle 1.83 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000122_0001
Figure imgf000121_0002
Table 1.83: Preferred compounds of the formula (1.83) are the compounds 1.83-1 to 1.83-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.83-1 to 1.83-400 of Table 1.83 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000122_0001

Tabelle 1.84: Bevorzugte Verbindungen der Formel (1.84) sind die Verbindungen 1.84-1 bis 1.84-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.84-1 bis 1.84-400 der Tabelle 1.84 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.84: Preferred compounds of the formula (1.84) are the compounds 1.84-1 to 1.84-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.84-1 to 1.84-400 of Table 1.84 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000122_0002
Tabelle 1.85: Bevorzugte Verbindungen der Formel (1.85) sind die Verbindungen 1.1-85 bis I 85-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.85-1 bis 1.85-400 der Tabelle 1.85 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000123_0001
Figure imgf000122_0002
Table 1.85: Preferred compounds of the formula (1.85) are the compounds 1.1-85 to I 85-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.85-1 to 1.85-400 of Table 1.85 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000123_0001

Tabelle 1.86: Bevorzugte Verbindungen der Formel (1.86) sind die Verbindungen 1.86-1 bis 1.86-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.86-1 bis 1.86-400 der Tabelle 1.86 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.86: Preferred compounds of the formula (1.86) are the compounds 1.86-1 to 1.86-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.86-1 to 1.86-400 of Table 1.86 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000123_0002
Tabelle 1.87: Bevorzugte Verbindungen der Formel (1.87) sind die Verbindungen 1.87-1 bis 1.87-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.87-1 bis 1.87-400 der Tabelle 1.87 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000124_0001
Figure imgf000123_0002
Table 1.87: Preferred compounds of the formula (1.87) are the compounds 1.87-1 to 1.87-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.87-1 to 1.87-400 of Table 1.87 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000124_0001

Tabelle 1.88: Bevorzugte Verbindungen der Formel (1.88) sind die Verbindungen 1.88-1 bis 1.88-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.88-1 bis 1.88-400 der Tabelle 1.88 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.88: Preferred compounds of the formula (1.88) are the compounds 1.88-1 to 1.88-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.88-1 to 1.88-400 of Table 1.88 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000124_0002
Tabelle 1.89: Bevorzugte Verbindungen der Formel (1.89) sind die Verbindungen 1.89-1 bis 1.89-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.89-1 bis 1.89-346 der Tabelle 1.89 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000125_0001
Figure imgf000124_0002
Table 1.89: Preferred compounds of the formula (1.89) are the compounds 1.89-1 to 1.89-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.89-1 to 1.89-346 of Table 1.89 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000125_0001

Tabelle 1.90: Bevorzugte Verbindungen der Formel (1.90) sind die Verbindungen 1.90-1 bis 1.90-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.90-1 bis 1.90-400 der Tabelle 1.90 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.90: Preferred compounds of the formula (1.90) are the compounds 1.90-1 to 1.90-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.90-1 to 1.90-400 of Table 1.90 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000125_0002
Tabelle 1.91 : Bevorzugte Verbindungen der Formel (1.91) sind die Verbindungen 1.91-1 bis 1.91-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.91-1 bis 1.91-400 der Tabelle 1.91 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000126_0001
Figure imgf000125_0002
Table 1.91: Preferred compounds of the formula (1.91) are the compounds 1.91-1 to 1.91-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.91-1 to 1.91-400 of Table 1.91 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000126_0001

Tabelle 1.92: Bevorzugte Verbindungen der Formel (1.92) sind die Verbindungen 1.92-1 bis 1.92-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.92-1 bis 1.92-400 der Tabelle 1.92 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.92: Preferred compounds of the formula (1.92) are the compounds 1.92-1 to 1.92-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.92-1 to 1.92-400 of Table 1.92 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000126_0002
Tabelle 1.93: Bevorzugte Verbindungen der Formel (1.93) sind die Verbindungen 1.93-1 bis 1.93-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.93-1 bis 1.93-400 der Tabelle 1.93 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000127_0001
Figure imgf000126_0002
Table 1.93: Preferred compounds of the formula (1.93) are the compounds 1.93-1 to 1.93-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.93-1 to 1.93-400 of Table 1.93 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000127_0001

Tabelle 1.94: Bevorzugte Verbindungen der Formel (1.94) sind die Verbindungen 1.94-1 bis 1.94-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.94-1 bis 1.94-400 der Tabelle 1.94 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.94: Preferred compounds of the formula (1.94) are the compounds 1.94-1 to 1.94-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.94-1 to 1.94-400 of Table 1.94 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000127_0002
Tabelle 1.95: Bevorzugte Verbindungen der Formel (1.95) sind die Verbindungen 1.95-1 bis 1.95-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.95-1 bis 1.95-400 der Tabelle 1.95 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000128_0001
Figure imgf000127_0002
Table 1.95: Preferred compounds of the formula (1.95) are the compounds 1.95-1 to 1.95-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.95-1 to 1.95-400 of Table 1.95 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000128_0001

Tabelle 1.96: Bevorzugte Verbindungen der Formel (1.96) sind die Verbindungen 1.96-1 bis 1.96-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.96-1 bis 1.96-400 der Tabelle 1.96 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.96: Preferred compounds of the formula (1.96) are the compounds 1.96-1 to 1.96-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.96-1 to 1.96-400 of Table 1.96 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000128_0002
Tabelle 1.97: Bevorzugte Verbindungen der Formel (1.97) sind die Verbindungen 1.97-1 bis 1.97-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.97-1 bis 1.97-400 der Tabelle 1.97 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000129_0001
Figure imgf000128_0002
Table 1.97: Preferred compounds of the formula (1.97) are the compounds 1.97-1 to 1.97-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.97-1 to 1.97-400 of Table 1.97 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000129_0001

Tabelle 1.98: Bevorzugte Verbindungen der Formel (1.98) sind die Verbindungen 1.98-1 bis 1.98-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.98-1 bis 1.98-400 der Tabelle 1.98 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.98: Preferred compounds of the formula (1.98) are the compounds 1.98-1 to 1.98-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.98-1 to 1.98-400 of Table 1.98 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000129_0002
Tabelle 1.99: Bevorzugte Verbindungen der Formel (1.99) sind die Verbindungen 1.99-1 bis 1.99-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.99-1 bis 1.99-346 der Tabelle 1.99 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000130_0001
Figure imgf000129_0002
Table 1.99: Preferred compounds of the formula (1.99) are the compounds 1.99-1 to 1.99-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.99-1 to 1.99-346 of Table 1.99 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000130_0001

Tabelle L I 00: Bevorzugte Verbindungen der Formel (L I 00) sind die Verbindungen 11006-1 bis 1.100- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.100-1 bis 1.100-400 der Tabelle 1.100 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Preferred compounds of the formula (I00) are the compounds 11006-1 to 1100-400, in which Z has the meanings given in Table 1 in the respective line. The compounds 1.100-1 to 1.100-400 of Table 1.100 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000130_0002
Figure imgf000130_0002

Tabelle 1.101 : Bevorzugte Verbindungen der Formel (1.101 ) sind die Verbindungen 1.101-1 bis 1.101- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.101-1 bis 1.101-400 der Tabelle 1.101 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000131_0001
Table 1.101: Preferred compounds of the formula (1.101) are the compounds 1.101-1 to 1.101-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.101-1 to 1.101-400 of Table 1.101 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000131_0001

Tabelle 1.102: Bevorzugte Verbindungen der Formel (1.102) sind die Verbindungen 1.102-1 bis 1.102- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.102-1 bis 1.102-400 der Tabelle 1.102 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.102: Preferred compounds of the formula (1.102) are the compounds 1.102-1 to 1.102-400, in which Z has the meanings of Table 1 indicated in the respective line. The connection 1.102-1 to 1.102-400 of Table 1.102 are thus defined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000131_0002
Tabelle 1.103: Bevorzugte Verbindungen der Formel (1.103) sind die Verbindungen 1.103-1 bis 1.103- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.103-1 bis 1.1039-400 der Tabelle 1.103 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000132_0001
Figure imgf000131_0002
Table 1.103: Preferred compounds of the formula (1.103) are the compounds 1.103-1 to 1.103-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.103-1 to 1.1039-400 of Table 1.103 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000132_0001

Tabelle 1.104: Bevorzugte Verbindungen der Formel (1.104) sind die Verbindungen 1.104-1 bis 1.104- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.104-1 bis 1.104-400 der Tabelle 1.104 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.104: Preferred compounds of the formula (1.104) are the compounds 1.104-1 to 1.104-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.104-1 to 1.104-400 of Table 1.104 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000132_0002
Figure imgf000132_0002

Tabelle 1.105: Bevorzugte Verbindungen der Formel (1.105) sind die Verbindungen 1.105-1 bis 1.105- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.105-1 bis 1.105-400 der Tabelle 1.105 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000133_0001
Table 1.105: Preferred compounds of the formula (1.105) are the compounds 1.105-1 to 1.105-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.105-1 to 1.105-400 of Table 1.105 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000133_0001

Tabelle 1.106: Bevorzugte Verbindungen der Formel (1.106) sind die Verbindungen 1.106-1 bis 1.106- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.106-1 bis 1.106-400 der Tabelle 1.106 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.106: Preferred compounds of the formula (1.106) are the compounds 1.106-1 to 1.106-400, wherein Z has the meaning given in the respective line of Table 1. The connection 1.106-1 to 1.106-400 of Table 1.106 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000133_0002
Figure imgf000133_0002

Tabelle 1.107: Bevorzugte Verbindungen der Formel (1.107) sind die Verbindungen 1.107-1 bis 1.107- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.107-1 bis 1.107-400 der Tabelle 1.107 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000134_0001
Table 1.107: Preferred compounds of the formula (1.107) are the compounds 1.107-1 to 1.107-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.107-1 to 1.107-400 of Table 1.107 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000134_0001

Tabelle 1.108: Bevorzugte Verbindungen der Formel (1.108) sind die Verbindungen 1.108-1 bis 1.108- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.108-1 bis 1.108-400 der Tabelle 1.108 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.108: Preferred compounds of the formula (1.108) are the compounds 1.108-1 to 1.108-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.108-1 to 1.108-400 of Table 1.108 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000134_0002
Figure imgf000134_0002

Tabelle 1.109: Bevorzugte Verbindungen der Formel (1.109) sind die Verbindungen 1.109-1 bis 1.109- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.109-1 bis 1.109-400 der Tabelle 1.109 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.109: Preferred compounds of the formula (1.109) are the compounds 1.109-1 to 1.109-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.109-1 to 1.109-400 of Table 1.109 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000135_0001
Figure imgf000135_0001

Tabelle 1.110: Bevorzugte Verbindungen der Formel (1.110) sind die Verbindungen L I 10-1 bis L I 10- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 10-1 bis L I 10-400 der Tabelle LI 10 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.110: Preferred compounds of the formula (1.110) are the compounds L I 10-1 to L I 10-400, wherein Z has the meanings of Table 1 given in the respective line. The compound L I 10-1 to L I 10-400 of the table LI 10 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000135_0002
Figure imgf000135_0002

Tabelle 1.111 : Bevorzugte Verbindungen der Formel (1.111 ) sind die Verbindungen I. l l l-l bis 1.111- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung I. l l l-l bis 1.111-400 der Tabelle 1.111 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000136_0001
Table 1.111: Preferred compounds of the formula (1.111) are the compounds I. ll ll to 1.111-400, in which Z has the meanings of Table 1 indicated in the respective line. The compound I. ll ll to 1.111-400 of Table 1.111 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000136_0001

Tabelle 1.112: Bevorzugte Verbindungen der Formel (1.112) sind die Verbindungen L I 12-1 bis L I 12- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 12-1 bis L I 12-400 der Tabelle LI 12 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.112: Preferred compounds of the formula (1.112) are the compounds L I 12-1 to L I 12-400, in which Z has the meanings of Table 1 indicated in the respective line. The connection L I 12-1 to L I 12-400 of the table LI 12 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000136_0002
Figure imgf000136_0002

Tabelle LI 13: Bevorzugte Verbindungen der Formel (LI 13) sind die Verbindungen L I 13-1 bis L I 13- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 13-1 bis L I 13-400 der Tabelle LI 13 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table LI 13: Preferred compounds of the formula (LI 13) are the compounds LI 13-1 to LI 13-400, wherein Z has the meaning given in the respective line of Table 1. The connection LI 13-1 to LI 13-400 of the table LI 13 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000137_0001
Figure imgf000137_0001

Tabelle 1.114: Bevorzugte Verbindungen der Formel (1.114) sind die Verbindungen 1.114-1 bis 1.114- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 14-1 bis L I 14-400 der Tabelle L I 14 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.114: Preferred compounds of the formula (1.114) are the compounds 1.114-1 to 1.114-400, wherein Z has the meanings given in Table 1 of each Table. The compound L I 14-1 to L I 14-400 of the table L I 14 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000137_0002
Figure imgf000137_0002

Tabelle 1.115: Bevorzugte Verbindungen der Formel (1.115) sind die Verbindungen 1.115-1 bis 1.115- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 15-1 bis L I 15-400 der Tabelle L I 15 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.115: Preferred compounds of the formula (1.115) are the compounds 1.115-1 to 1.115-400, wherein Z has the meanings indicated in the respective line of Table 1. The connection LI 15-1 to LI 15-400 of the table LI 15 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000138_0001
Figure imgf000138_0001

Tabelle L I 16: Bevorzugte Verbindungen der Formel (L I 16) sind die Verbindungen L I 16-1 bis L I 16- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 16-1 bis L I 16-400 der Tabelle L I 16 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Preferred compounds of the formula (L I 16) are the compounds L I 16-1 to L I 16-400, wherein Z has the meanings of Table 1 given in the respective line. The compound L I 16-1 to L I 16-400 of Table L I 16 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000138_0002
Figure imgf000138_0002

Tabelle 1.117: Bevorzugte Verbindungen der Formel (L I 17) sind die Verbindungen 1.117-1 bis 1.117- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 17-1 bis L I 17-400 der Tabelle L I 17 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000139_0001
Table 1.117: Preferred compounds of the formula (LI 17) are the compounds 1.117-1 to 1.117-400, wherein Z has the meaning given in the respective line of Table 1. The connection LI 17-1 to LI 17-400 of Table LI 17 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000139_0001

Tabelle 1.118: Bevorzugte Verbindungen der Formel (1.118) sind die Verbindungen 1.118-1 bis 1.118- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 18-1 bis L I 18-400 der Tabelle L I 18 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.118: Preferred compounds of the formula (1.118) are the compounds 1.118-1 to 1.118-400, wherein Z has the meanings of Table 1 given in the respective line. The compound L I 18-1 to L I 18-400 of the table L I 18 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000139_0002
Figure imgf000139_0002

Tabelle L I 19: Bevorzugte Verbindungen der Formel (L I 19) sind die Verbindungen L I 19-1 bis L I 19- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung L I 19-1 bis L I 19-400 der Tabelle L I 19 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table LI 19: Preferred compounds of the formula (LI 19) are the compounds LI 19-1 to LI 19-400, wherein Z has the meaning given in the respective line of Table 1. The connection LI 19-1 to LI 19-400 of the table LI 19 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000140_0001
Figure imgf000140_0001

Tabelle 1.120: Bevorzugte Verbindungen der Formel (1.120) sind die Verbindungen 1.120-1 bis 1.120- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.120-1 bis 1.120-400 der Tabelle 1.120 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.120: Preferred compounds of the formula (1.120) are the compounds 1,120-1 to 1,120-400, in which Z has the meanings given in Table 1 of each line. The connection 1.120-1 to 1.120-400 of Table 1.120 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000140_0002
Figure imgf000140_0002

Tabelle 1.121 : Bevorzugte Verbindungen der Formel (1.121) sind die Verbindungen 1.121-1 bis 1.121- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.121-1 bis 1.121-400 der Tabelle 1.121 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.121: Preferred compounds of the formula (1.121) are the compounds 1.121-1 to 1.121-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.121-1 to 1.121-400 of Table 1.121 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000141_0001
Figure imgf000141_0001

Tabelle 1.122: Bevorzugte Verbindungen der Formel (1.122) sind die Verbindungen 1.122-1 bis 1.122- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.122-1 bis 1.122-400 der Tabelle 1.122 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.122: Preferred compounds of the formula (1.122) are the compounds 1.122-1 to 1.122-400, wherein Z has the meanings given in Table 1 of each line. The connection 1.122-1 to 1.122-400 of Table 1.122 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000141_0002
Figure imgf000141_0002

Tabelle 1.123: Bevorzugte Verbindungen der Formel (1.123) sind die Verbindungen 1.123-1 bis 1.123- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.123-1 bis 1.123-400 der Tabelle 1.123 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.123: Preferred compounds of the formula (1.123) are the compounds 1.123-1 to 1.123-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.123-1 to 1.123-400 of Table 1.123 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000142_0001
Figure imgf000142_0001

Tabelle 1.124: Bevorzugte Verbindungen der Formel (1.124) sind die Verbindungen 1.124-1 bis 1.124- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.124-1 bis 1.124-400 der Tabelle 1.124 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.124: Preferred compounds of the formula (1.124) are the compounds 1.124-1 to 1.124-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.124-1 to 1.124-400 of Table 1.124 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000142_0002
Figure imgf000142_0002

Tabelle 1.125: Bevorzugte Verbindungen der Formel (1.125) sind die Verbindungen 1.125-1 bis 1.125- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.125-1 bis 1.125-400 der Tabelle 1.125 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000143_0001
Table 1.125: Preferred compounds of the formula (1.125) are the compounds 1.125-1 to 1.125-400, wherein Z has the meaning given in the respective line of Table 1. The connection 1.125-1 to 1.125-400 of Table 1.125 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000143_0001

Tabelle 1.126: Bevorzugte Verbindungen der Formel (1.126) sind die Verbindungen 1.126-1 bis 1.126- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.126-1 bis 1.126-400 der Tabelle 1.126 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.126: Preferred compounds of the formula (1.126) are the compounds 1.126-1 to 1.126-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.126-1 to 1.126-400 of Table 1.126 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000143_0002
Figure imgf000143_0002

Tabelle 1.127: Bevorzugte Verbindungen der Formel (1.127) sind die Verbindungen 1.127-1 bis 1.127- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.127-1 bis 1.127-400 der Tabelle 1.127 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000144_0001
Table 1.127: Preferred compounds of the formula (1.127) are the compounds 1.127-1 to 1.127-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.127-1 to 1.127-400 of Table 1.127 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000144_0001

Tabelle 1.128: Bevorzugte Verbindungen der Formel (1.128) sind die Verbindungen 1.128-1 bis 1.128- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.128-1 bis 1.128-400 der Tabelle 1.128 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.128: Preferred compounds of the formula (1.128) are the compounds 1.128-1 to 1.128-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.128-1 to 1.128-400 of Table 1.128 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000144_0002
Figure imgf000144_0002

Tabelle 1.129: Bevorzugte Verbindungen der Formel (1.129) sind die Verbindungen 1.129-1 bis 1.129- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.129-1 bis 1.129-400 der Tabelle 1.129 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.129: Preferred compounds of the formula (1.129) are the compounds 1.129-1 to 1.129-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.129-1 to 1.129-400 of Table 1.129 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000145_0001
Figure imgf000145_0001

Tabelle 1.130: Bevorzugte Verbindungen der Formel (1.130) sind die Verbindungen 1.130-1 bis 1.130- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.130-1 bis 1.130-400 der Tabelle 1.130 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.130: Preferred compounds of the formula (1.130) are the compounds 1.130-1 to 1.130-400, in which Z has the meanings given in Table 1 of each line. The compounds 1.130-1 to 1.130-400 of Table 1.130 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000145_0002
Figure imgf000145_0002

Tabelle 1.131 : Bevorzugte Verbindungen der Formel (1.131) sind die Verbindungen 1.131-1 bis 1.131- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.131-1 bis 1.131-400 der Tabelle 1.131 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000146_0001
Table 1.131: Preferred compounds of the formula (1.131) are the compounds 1.131-1 to 1.131-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.131-1 to 1.131-400 of Table 1.131 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000146_0001

Tabelle 1.132: Bevorzugte Verbindungen der Formel (1.132) sind die Verbindungen 1.132-1 bis 1.132- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.132-1 bis 1.132-400 der Tabelle 1.132 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.132: Preferred compounds of the formula (1.132) are the compounds 1.132-1 to 1.132-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.132-1 to 1.132-400 of Table 1.132 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000146_0002
Figure imgf000146_0002

Tabelle 1.133: Bevorzugte Verbindungen der Formel (1.133) sind die Verbindungen 1.133-1 bis 1.133- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.133-1 bis 1.133-400 der Tabelle 1.133 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.133: Preferred compounds of the formula (1.133) are the compounds 1.133-1 to 1.133-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.133-1 to 1.133-400 of Table 1.133 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000147_0001
Figure imgf000147_0001

Tabelle 1.134: Bevorzugte Verbindungen der Formel (1.134) sind die Verbindungen 1.134-1 bis 1.134- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.134-1 bis 1.134-400 der Tabelle 1.134 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.134: Preferred compounds of the formula (1.134) are the compounds 1.134-1 to 1.134-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.134-1 to 1.134-400 of Table 1.134 are thus characterized by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000147_0002
Figure imgf000147_0002

Tabelle 1.135: Bevorzugte Verbindungen der Formel (1.135) sind die Verbindungen 1.135-1 bis 1.135- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.135-1 bis 1.135-400 der Tabelle 1.135 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.135: Preferred compounds of the formula (1.135) are the compounds 1.135-1 to 1.135-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.135-1 to 1.135-400 of Table 1.135 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000148_0001
Figure imgf000148_0001

Tabelle 1.136: Bevorzugte Verbindungen der Formel (1.136) sind die Verbindungen 1.136-1 bis 1.136- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.136-1 bis 1.136-400 der Tabelle 1.136 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.136: Preferred compounds of the formula (1.136) are the compounds 1.136-1 to 1.136-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.136-1 to 1.136-400 of Table 1.136 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000148_0002
Figure imgf000148_0002

Tabelle 1.137: Bevorzugte Verbindungen der Formel (1.137) sind die Verbindungen 1.137-1 bis 1.137- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.137-1 bis 1.137-400 der Tabelle 1.137 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.137: Preferred compounds of the formula (1.137) are the compounds 1.137-1 to 1.137-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.137-1 to 1.137-400 of Table 1.137 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000149_0001
Figure imgf000149_0001

Tabelle 1.138: Bevorzugte Verbindungen der Formel (1.138) sind die Verbindungen 1.138-1 bis 1.138- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.138-1 bis 1.138-400 der Tabelle 1.138 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.138: Preferred compounds of the formula (1.138) are the compounds 1.138-1 to 1.138-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.138-1 to 1.138-400 of Table 1.138 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000149_0002
Figure imgf000149_0002

Tabelle 1.139: Bevorzugte Verbindungen der Formel (1.139) sind die Verbindungen 1.139-1 bis 1.139- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.139-1 bis 1.139-400 der Tabelle 1.139 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.139: Preferred compounds of the formula (1.139) are the compounds 1.139-1 to 1.139-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.139-1 to 1.139-400 of Table 1.139 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000150_0001
Figure imgf000150_0001

Tabelle 1.140: Bevorzugte Verbindungen der Formel (1.140) sind die Verbindungen 1.140-1 bis 1.140- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.140-1 bis 1.140-400 der Tabelle 1.140 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.140: Preferred compounds of the formula (1.140) are the compounds 1.140-1 to 1.140-400, wherein Z has the meanings of Table 1 given in the respective line. The connection 1.140-1 to 1.140-400 of Table 1.140 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000150_0002
Figure imgf000150_0002

Tabelle 1.141 : Bevorzugte Verbindungen der Formel (1.141) sind die Verbindungen 1.141-1 bis 1.141- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.141-1 bis 1.141-400 der Tabelle 1.141 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.141: Preferred compounds of the formula (1.141) are the compounds 1.141-1 to 1.141-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.141-1 to 1.141-400 of Table 1.141 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000151_0001
Figure imgf000151_0001

Tabelle 1.142: Bevorzugte Verbindungen der Formel (1.142) sind die Verbindungen 1.142-1 bis 1.142- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.142-1 bis 1.142-400 der Tabelle 1.142 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.142: Preferred compounds of the formula (1.142) are the compounds 1.142-1 to 1.142-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.142-1 to 1.142-400 of Table 1.142 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000151_0002
Figure imgf000151_0002

Tabelle 1.143: Bevorzugte Verbindungen der Formel (1.143) sind die Verbindungen 1.143-1 bis 1.143- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.143-1 bis 1.143-400 der Tabelle 1.143 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.143: Preferred compounds of the formula (1.143) are the compounds 1.143-1 to 1.143-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.143-1 to 1.143-400 of Table 1.143 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000152_0001
Figure imgf000152_0001

Tabelle 1.144: Bevorzugte Verbindungen der Formel (1.144) sind die Verbindungen 1.144-1 bis 1.144- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.144-1 bis 1.144-400 der Tabelle 1.144 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.144: Preferred compounds of the formula (1.144) are the compounds 1.144-1 to 1.144-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.144-1 to 1.144-400 of Table 1.144 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000152_0002
Figure imgf000152_0002

Tabelle 1.145: Bevorzugte Verbindungen der Formel (1.145) sind die Verbindungen 1.145-1 bis 1.145- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.145-1 bis 1.145-400 der Tabelle 1.145 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.145: Preferred compounds of the formula (1.145) are the compounds 1.145-1 to 1.145-400, wherein Z has the meanings given in Table 1 of each Table. The connection 1.145-1 to 1.145-400 of Table 1.145 are thus by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000153_0001
Figure imgf000153_0001

Tabelle 1.146: Bevorzugte Verbindungen der Formel (1.146) sind die Verbindungen 1.146-1 bis 1.146- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.146-1 bis 1.146-400 der Tabelle 1.146 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.146: Preferred compounds of the formula (1.146) are the compounds 1.146-1 to 1.146-400, wherein Z has the meaning given in the respective line of Table 1. The compounds 1.146-1 to 1.146-400 of Table 1.146 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000153_0002
Figure imgf000153_0002

Tabelle 1.147: Bevorzugte Verbindungen der Formel (1.147) sind die Verbindungen 1.147-1 bis 1.147- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.147-1 bis 1.147-400 der Tabelle 1.147 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000154_0001
Table 1.147: Preferred compounds of the formula (1.147) are the compounds 1.147-1 to 1.147-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.147-1 to 1.147-400 of Table 1.147 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000154_0001

Tabelle 1.148: Bevorzugte Verbindungen der Formel (1.148) sind die Verbindungen 1.48-1 bis 1.148-400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.148-1 bis 1.148-400 der Tabelle 1.148 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.148: Preferred compounds of the formula (1.148) are the compounds 1.48-1 to 1.148-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.148-1 to 1.148-400 of Table 1.148 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000154_0002
Tabelle 1.149: Bevorzugte Verbindungen der Formel (1.149) sind die Verbindungen 1.149-1 bis 1.149- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.149-1 bis 1.149-400 der Tabelle 1.85 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.
Figure imgf000154_0002
Table 1.149: Preferred compounds of the formula (1.149) are the compounds 1.149-1 to 1.149-400, wherein Z has the meaning given in the respective line of Table 1. The compounds 1.149-1 to 1.149-400 of Table 1.85 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000155_0001
Figure imgf000155_0001

Tabelle 1.150: Bevorzugte Verbindungen der Formel (1.150) sind die Verbindungen 1.150-1 bis 1.150- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.150-1 bis 1.150-400 der Tabelle 1.150 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.150: Preferred compounds of the formula (1.150) are the compounds 1.150-1 to 1.150-400, in which Z has the meanings of Table 1 indicated in the respective line. The connection 1.150-1 to 1.150-400 of Table 1.150 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000155_0002
Figure imgf000155_0002

Tabelle 1.151 : Bevorzugte Verbindungen der Formel (1.151) sind die Verbindungen 1.151-1 bis 1.151- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.151-1 bis 1.151-400 der Tabelle 1.151 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.151: Preferred compounds of the formula (1.151) are the compounds 1.151-1 to 1.151-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.151-1 to 1.151-400 of Table 1.151 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000156_0001
Figure imgf000156_0001

Tabelle 1.152: Bevorzugte Verbindungen der Formel (1.152) sind die Verbindungen 1.152-1 bis 1.152- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.152-1 bis 1.152-400 der Tabelle 1.152 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.152: Preferred compounds of the formula (1.152) are the compounds 1.152-1 to 1.152-400, wherein Z has the meanings given in Table 1 of each line. The connection 1.152-1 to 1.152-400 of Table 1.152 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000156_0002
Figure imgf000156_0002

Tabelle 1.153: Bevorzugte Verbindungen der Formel (1.153) sind die Verbindungen 1.153-1 bis 1.153- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.153-1 bis 1.153-400 der Tabelle 1.153 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000157_0001
Table 1.153: Preferred compounds of the formula (1.153) are the compounds 1.153-1 to 1.153-400, wherein Z has the meanings of Table 1 indicated in the respective line. The compounds 1.153-1 to 1.153-400 of Table 1.153 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000157_0001

Tabelle 1.154: Bevorzugte Verbindungen der Formel (1.154) sind die Verbindungen 1.154-1 bis 1.154- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.154-1 bis 1.154-400 der Tabelle 1.154 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.154: Preferred compounds of the formula (1.154) are the compounds 1.154-1 to 1.154-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.154-1 to 1.154-400 of Table 1.154 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000157_0002
Figure imgf000157_0002

Tabelle 1.155: Bevorzugte Verbindungen der Formel (1.155) sind die Verbindungen 1.155-1 bis 1.155- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.155-1 bis 1.155-400 der Tabelle 1.155 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.155: Preferred compounds of the formula (1.155) are the compounds 1.155-1 to 1.155-400, wherein Z has the meaning given in the respective line of Table 1. The connection 1.155-1 to 1.155-400 of Table 1.155 are thus determined by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000158_0001
Figure imgf000158_0001

Tabelle 1.156: Bevorzugte Verbindungen der Formel (1.156) sind die Verbindungen 1.156-1 bis 1.156- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.156-1 bis 1.156-400 der Tabelle 1.156 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.156: Preferred compounds of the formula (1.156) are the compounds 1.156-1 to 1.156-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.156-1 to 1.156-400 of Table 1.156 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000158_0002
Figure imgf000158_0002

Tabelle 1.157: Bevorzugte Verbindungen der Formel (1.157) sind die Verbindungen 1.157-1 bis 1.157- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.157-1 bis 1.157-400 der Tabelle 1.157 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.157: Preferred compounds of the formula (1.157) are the compounds 1.157-1 to 1.157-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.157-1 to 1.157-400 of Table 1.157 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000159_0001
Figure imgf000159_0001

Tabelle 1.158: Bevorzugte Verbindungen der Formel (1.158) sind die Verbindungen 1.158-1 bis 1.158- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.158-1 bis 1.158-400 der Tabelle 1.158 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.158: Preferred compounds of the formula (1.158) are the compounds 1.158-1 to 1.158-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.158-1 to 1.158-400 of Table 1.158 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000159_0002
Figure imgf000159_0002

Tabelle 1.159: Bevorzugte Verbindungen der Formel (1.159) sind die Verbindungen 1.159-1 bis 1.159- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.159-1 bis 1.159-400 der Tabelle 1.159 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000160_0001
Table 1.159: Preferred compounds of the formula (1.159) are the compounds 1.159-1 to 1.159-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.159-1 to 1.159-400 of Table 1.159 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000160_0001

Tabelle 1.160: Bevorzugte Verbindungen der Formel (1.160) sind die Verbindungen 1.160-1 bis 1.160- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.160-1 bis 1.160-400 der Tabelle 1.160 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.160: Preferred compounds of the formula (1.160) are the compounds 1.160-1 to 1.160-400, wherein Z has the meaning given in the respective line of Table 1. The connection 1.160-1 to 1.160-400 of Table 1.160 are thus determined by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000160_0002
Figure imgf000160_0002

Tabelle 1.161 : Bevorzugte Verbindungen der Formel (1.161) sind die Verbindungen 1.161-1 bis 1.161 - 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.161-1 bis 1.161-400 der Tabelle 1.161 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.161: Preferred compounds of the formula (1.161) are the compounds 1.161-1 to 1.161-400, wherein Z has the meanings of Table 1 indicated in the respective line. The compounds 1.161-1 to 1.161-400 of Table 1.161 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000161_0001
Figure imgf000161_0001

Tabelle 1.162: Bevorzugte Verbindungen der Formel (1.162) sind die Verbindungen 1.162-1 bis 1.162- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.162-1 bis 1.162-400 der Tabelle 1.162 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.162: Preferred compounds of the formula (1.162) are the compounds 1.162-1 to 1.162-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.162-1 to 1.162-400 of Table 1.162 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000161_0002
Figure imgf000161_0002

Tabelle 1.163: Bevorzugte Verbindungen der Formel (1.163) sind die Verbindungen 1.163-1 bis 1.163- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.163-1 bis 1.163-400 der Tabelle 1.163 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.163: Preferred compounds of the formula (1.163) are the compounds 1.163-1 to 1.163-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.163-1 to 1.163-400 of Table 1.163 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000162_0001
Figure imgf000162_0001

Tabelle 1.164: Bevorzugte Verbindungen der Formel (1.164) sind die Verbindungen 1.164-1 bis 1.164- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.164-1 bis 1.164-400 der Tabelle 1.164 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.164: Preferred compounds of the formula (1.164) are the compounds 1.164-1 to 1.164-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.164-1 to 1.164-400 of Table 1.164 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000162_0002
Figure imgf000162_0002

Tabelle 1.165: Bevorzugte Verbindungen der Formel (1.165) sind die Verbindungen 1.165-1 bis 1.165- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.165-1 bis 1.165-400 der Tabelle 1.165 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.165: Preferred compounds of the formula (1.165) are the compounds 1.165-1 to 1.165-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.165-1 to 1.165-400 of Table 1.165 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000163_0001
Figure imgf000163_0001

Tabelle 1.166: Bevorzugte Verbindungen der Formel (1.166) sind die Verbindungen 1.166-1 bis 1.166- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.166-1 bis 1.166-400 der Tabelle 1.166 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.166: Preferred compounds of the formula (1.166) are the compounds 1.166-1 to 1.166-400, wherein Z has the meaning given in the respective line of Table 1. The compounds 1.166-1 to 1.166-400 of Table 1.166 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000163_0002
Figure imgf000163_0002

Tabelle 1.167: Bevorzugte Verbindungen der Formel (1.167) sind die Verbindungen 1.167-1 bis 1.167- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.167-1 bis 1.167-400 der Tabelle 1.167 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000164_0001
Table 1.167: Preferred compounds of the formula (1.167) are the compounds 1.167-1 to 1.167-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.167-1 to 1.167-400 of Table 1.167 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000164_0001

Tabelle 1.168: Bevorzugte Verbindungen der Formel (1.168) sind die Verbindungen 1.168-1 bis 1.168- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.168-1 bis 1.168-400 der Tabelle 1.168 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.168: Preferred compounds of the formula (1.168) are the compounds 1.168-1 to 1.168-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.168-1 to 1.168-400 of Table 1.168 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000164_0002
Figure imgf000164_0002

Tabelle 1.169: Bevorzugte Verbindungen der Formel (1.169) sind die Verbindungen 1.169-1 bis 1.169- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.169-1 bis 1.169-400 der Tabelle 1.169 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000165_0001
Table 1.169: Preferred compounds of the formula (1.169) are the compounds 1.169-1 to 1.169-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.169-1 to 1.169-400 of Table 1.169 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000165_0001

Tabelle 1.170: Bevorzugte Verbindungen der Formel (1.170) sind die Verbindungen 1.170-1 bis 1.170- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.170-1 bis 1.170-400 der Tabelle 1.170 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.170: Preferred compounds of the formula (1,170) are the compounds 1,170-1 to 1,170,400, in which Z has the meanings of Table 1 indicated in the respective line. The connection 1.170-1 to 1.170-400 of Table 1.170 are thus by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000165_0002
Figure imgf000165_0002

Tabelle 1.171 : Bevorzugte Verbindungen der Formel (1.171) sind die Verbindungen 1.171-1 bis 1.171- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.171-1 bis 1.171-400 der Tabelle 1.171 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000166_0001
Table 1.171: Preferred compounds of the formula (1.171) are the compounds 1.171-1 to 1.171-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.171-1 to 1.171-400 of Table 1.171 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000166_0001

Tabelle 1.172: Bevorzugte Verbindungen der Formel (1.172) sind die Verbindungen 1.172-1 bis 1.172- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.172-1 bis 1.172-400 der Tabelle 1.172 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.172: Preferred compounds of the formula (1.172) are the compounds 1.172-1 to 1.172-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.172-1 to 1.172-400 of Table 1.172 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000166_0002
Figure imgf000166_0002

Tabelle 1.173: Bevorzugte Verbindungen der Formel (1.173) sind die Verbindungen 1.173-1 bis 1.173- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.173-1 bis 1.173-400 der Tabelle 1.173 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000167_0001
Table 1.173: Preferred compounds of the formula (1.173) are the compounds 1.173-1 to 1.173-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.173-1 to 1.173-400 of Table 1.173 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000167_0001

Tabelle 1.174: Bevorzugte Verbindungen der Formel (1.174) sind die Verbindungen 1.174-1 bis 1.174- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.174-1 bis 1.174-400 der Tabelle 1.174 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.174: Preferred compounds of the formula (1.174) are the compounds 1.174-1 to 1.174-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.174-1 to 1.174-400 of Table 1.174 are thus distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000167_0002
Figure imgf000167_0002

Tabelle 1.175: Bevorzugte Verbindungen der Formel (1.175) sind die Verbindungen 1.175-1 bis 1.175- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.175-1 bis 1.175-400 der Tabelle 1.175 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000168_0001
Table 1.175: Preferred compounds of the formula (1.175) are the compounds 1.175-1 to 1.175-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.175-1 to 1.175-400 of Table 1.175 are thus characterized by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000168_0001

Tabelle 1.176: Bevorzugte Verbindungen der Formel (1.176) sind die Verbindungen 1.176-1 bis 1.176- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.176-1 bis 1.176-400 der Tabelle 1.176 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert. Table 1.176: Preferred compounds of the formula (1.176) are the compounds 1.176-1 to 1.176-400, wherein Z has the meanings of Table 1 given in the respective line. The compounds 1.176-1 to 1.176-400 of Table 1.176 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.

Figure imgf000168_0002
Figure imgf000168_0002

Tabelle 1.177: Bevorzugte Verbindungen der Formel (1.177) sind die Verbindungen 1.177-1 bis 1.177- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.177-1 bis 1.177-400 der Tabelle 1.177 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000169_0001
Table 1.177: Preferred compounds of the formula (1.177) are the compounds 1.177-1 to 1.177-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.177-1 to 1.177-400 of Table 1.177 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000169_0001

Tabelle 1.178: Bevorzugte Verbindungen der Formel (1.178) sind die Verbindungen 1.178-1 bis 1.178- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.178-1 bis 1.178-400 der Tabelle 1.178 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.178: Preferred compounds of the formula (1.178) are the compounds 1.178-1 to 1.178-400, wherein Z has the meanings given in Table 1 of each Table. The compounds 1.178-1 to 1.178-400 of Table 1.178 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000169_0002
Figure imgf000169_0002

Tabelle 1.179: Bevorzugte Verbindungen der Formel (1.179) sind die Verbindungen 1.179-1 bis 1.179- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.179-1 bis 1.179-400 der Tabelle 1.179 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert.

Figure imgf000170_0001
Table 1.179: Preferred compounds of the formula (1.179) are the compounds 1.179-1 to 1.179-400, wherein Z has the meanings indicated in the respective line of Table 1. The compounds 1.179-1 to 1.179-400 of Table 1.179 are thus distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.
Figure imgf000170_0001

Tabelle 1.180: Bevorzugte Verbindungen der Formel (1.180) sind die Verbindungen 1.180-1 bis 1.180- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.180-1 bis 1.180-400 der Tabelle 1.180 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.180: Preferred compounds of the formula (1.180) are the compounds 1.180-1 to 1.180-400, in which Z has the meanings of Table 1 indicated in the respective line. The connection 1.180-1 to 1.180-400 of Table 1.180 are thus determined by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Figure imgf000170_0002
Figure imgf000170_0002

Tabelle 1.181 : Bevorzugte Verbindungen der Formel (1.181) sind die Verbindungen 1.181-1 bis 1.181 - 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindung 1.181-1 bis 1.181-400 der Tabelle 1.181 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der oben stehenden Tabelle 1 definiert.

Figure imgf000171_0001
Table 1.181: Preferred compounds of the formula (1.181) are the compounds 1.181-1 to 1.181-400, in which Z has the meanings of Table 1 indicated in the respective line. The compounds 1.181-1 to 1.181-400 of Table 1.181 are therefore distinguished by the meaning of the respective entries no. 1 to 400 for Z of Table 1 above.
Figure imgf000171_0001

Tabelle 1.182: Bevorzugte Verbindungen der Formel (1.182) sind die Verbindungen 1.182-1 bis 1.182- 400, worin Z die in der jeweiligen Zeile angegebenen Bedeutungen der Tabelle 1 hat. Die Verbindungen 1.182-1 bis 1.182-400 der Tabelle 1.182 sind somit durch die Bedeutung der jeweiligen Einträge No. 1 bis 400 für Z der Tabelle 1 definiert. Table 1.182: Preferred compounds of the formula (1.182) are the compounds 1.182-1 to 1.182-400, wherein Z has the meanings given in Table 1 of each line. The compounds 1.182-1 to 1.182-400 of Table 1.182 are therefore distinguished by the meaning of the respective entries no. 1 to 400 defined for Z of Table 1.

Spektroskopische Daten ausgewählter Tabellenbeispiele: Spectroscopic data of selected table examples:

Ausgewählte detaillierte Synthesebeispiele für die erfindungsgemäßen Verbindungen der allgemeinen Formeln (I) sind im Folgenden aufgeführt. Die 'H-NMR-, 13C-NMR- und 19F-NMR-spektroskopischen Daten, die für die in den nachfolgenden Abschnitten beschriebenen chemischen Beispiele angegeben sind, (400 MHz bei 'H-NMR und 150 MHz bei 13C-NMR und 375 MHz bei "F-NMR, Lösungsmittel CDCb, CD3OD oder d6-DMSO, interner Standard: Tetramethylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Bruker erhalten, und die bezeichneten Signale haben die nachfolgend aufgeführten Bedeutungen: br = breit(es); s = Singulett, d = Dublett, t = Triplett, dd = Doppeldublett, ddd = Dublett eines Doppeldubletts, m = Multiplett, q = Quartett, quint = Quintett, sext = Sextett, sept = Septett, dq = Doppelquartett, dt = Doppeltriplett. Bei Diastereomerengemischen werden entweder die jeweils signifikanten Signale beider Diastereomere oder das charakteristische Signal des Hauptdiastereomers angegeben. Die verwendeten Abkürzungen für chemische Gruppen haben beispielsweise die nachfolgenden Bedeutungen: Me = CH3, Et = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t-Bu = C(CH3)3, n- Bu = unverzweigtes Butyl, n-Pr = unverzweigtes Propyl, i-Pr = verzweigtes Propyl, c-Pr = Cyclopropyl, c-Hex = Cyclohexyl. Selected detailed synthesis examples of the compounds of the general formulas (I) according to the invention are listed below. The 'H-NMR, 13 C-NMR and 19 F-NMR spectroscopic data given for the chemical examples described in the following sections (400 MHz for' H-NMR and 150 MHz for 13 C-NMR and 375 MHz in "F-NMR, solvent CDCb, CD3OD or d6-DMSO, internal standard: tetramethylsilane δ = 0.00 ppm) were obtained with a Bruker instrument and the designated signals have the meanings given below: br = broad (es); s = singlet, d = doublet, t = triplet, dd = double doublet, ddd = doublet of double doublet, m = multiplet, q = quartet, quint = quintet, sext = sextet, sept = septet, dq = double quartet, ., Me = CH 3 Et = CH2CH3, t-Hex = C (CH: dt = double triplet at diastereomers either the respective significant signals of both diastereomers, or the characteristic signal of the major diastereomer are specified, the abbreviations used for chemical groups example, have the following meanings. 3 ) 2CH (CH 3 ) 2, t-Bu = C (CH 3 ) 3 , n-Bu = unbranched butyl, n-Pr = unbranched propyl, i-Pr = branched propyl, c-Pr = cyclopropyl, c-hex = cyclohexyl.

Die nachfolgend aufgeführten spektroskopischen Daten ausgewählter Tabellenbeispiele wurden über klassische 'H-NMR-Interpretation oder über NMR-Peak-Listenverfahren ausgewertet. The spectroscopic data of selected table examples listed below were evaluated by classical 'H-NMR interpretation or by NMR peak list methods.

Klassische 'H-NMR-Interpretation NMR-Peak-Listenverfahren Classical 'H NMR interpretation NMR peak list procedures

Die 1H-NMR-Daten ausgewählter Beispiele werden in Form von 1H-NMR-Peaklisten notiert. Zu jedem Signalpeak wird erst der δ-Wert in ppm und dann die Signalintensität in runden Klammern aufgeführt. Die δ-Wert - Signalintensitäts- Zahlenpaare von verschiedenen Signalpeaks werden durch Semikolons voneinander getrennt aufgelistet. The 1H NMR data of selected examples are noted in terms of 1H NMR peak lists. For each signal peak, first the δ value in ppm and then the signal intensity in round brackets are listed. The δ-value signal intensity number pairs of different signal peaks are listed separated by semicolons.

Die Peakliste eines Beispieles hat daher die Form: δι (Intensität^; 82 (Intensität2); ; δ; (Intensität^; ; δη (Intensitätn) The peak list of an example therefore has the form: δι (intensity ^; 82 (intensity 2);; δ; (intensity ^;; δ η (intensity n )

Die Intensität scharfer Signale korreliert mit der Höhe der Signale in einem gedruckten Beispiel eines NMR-Spektrums in cm und zeigt die wirklichen Verhältnisse der Signalintensitäten. Bei breitenThe intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. In broad

Signalen können mehrere Peaks oder die Mitte des Signals und ihre relative Intensität im Vergleich zum intensivsten Signal im Spektrum gezeigt werden. Signals can show multiple peaks or the center of the signal and their relative intensity compared to the most intense signal in the spectrum.

Zur Kalibrierung der chemischen Verschiebung von 1H-NMR-Spektren benutzen wir Tetramethylsilan und/oder die chemische Verschiebung des Lösungsmittels, besondern im Falle von Spektren, die in DMSO gemessen werden. Daher kann in NMR-Peaklisten der Tetramethylsilan-Peak vorkommen, muss es aber nicht. To calibrate the chemical shift of 1H NMR spectra we use tetramethylsilane and / or the chemical shift of the solvent, especially in the case of spectra measured in DMSO. Therefore, the tetramethylsilane peak can occur in NMR peaks, but it does not have to.

Die Listen der IH-NMR-Peaks sind ähnlich den klassischen IH-NMR- Ausdrucken und enthalten somit gewöhnlich alle Peaks, die bei einer klassischen NMR-Interpretation aufgeführt werden. The lists of the IH-NMR peaks are similar to the classical IH-NMR prints and thus usually contain all the peaks that are listed in a classical NMR interpretation.

Darüber hinaus können sie wie klassische IH-NMR- Ausdrucke Lösungsmittelsignale, Signale von Stereoisomeren der Zielverbindungen, die ebenfalls Gegenstand der Erfindung sind, und/oder Peaks von Verunreinigungen zeigen. In addition, like classical IH-NMR prints, they can show solvent signals, signals from stereoisomers of the target compounds, which are also the subject of the invention, and / or peaks of impurities.

Bei der Angabe von Verbindungssignalen im Delta-Bereich von Lösungsmitteln und/oder Wasser sind in unseren Listen von IH-NMR-Peaks die gewöhnlichen Lösungsmittelpeaks, zum Beispiel Peaks von DMSO in DMSO-D6 und der Peak von Wasser, gezeigt, die gewöhnlich im Durchschnitt eine hohe Intensität aufweisen. When indicating compound signals in the delta range of solvents and / or water, our lists of IH NMR peaks show the usual solvent peaks, for example, peaks of DMSO in DMSO-D6 and the peak of water, which are usually average have a high intensity.

Die Peaks von Stereoisomeren der Targetverbindungen und/oder Peaks von Verunreinigungen haben gewöhnlich im Durchschnitt eine geringere Intensität als die Peaks der Zielverbindungen (zum Beispiel mit einer Reinheit von >90 %). Solche Stereoisomere und/oder Verunreinigungen können typisch für das jeweilige The peaks of stereoisomers of the target compounds and / or peaks of impurities usually have on average a lower intensity than the peaks of the target compounds (for example with a purity of> 90%). Such stereoisomers and / or impurities may be typical of each

Herstellungsverfahren sein. Ihre Peaks können somit dabei helfen, die Reproduktion Be manufacturing process. Their peaks can thus help the reproduction

Herstellungsverfahrens anhand von "Nebenprodukt-Fingerabdrucken" zu erkennen. Detect manufacturing process by "by-product fingerprints".

Einem Experten, der die Peaks der Zielverbindungen mit bekannten Verfahren (MestreC, ACD- Simulation, aber auch mit empirisch ausgewerteten Erwartungswerten) berechnet, kann je nach Bedarf die Peaks der Zielverbindungen isolieren, wobei gegebenenfalls zusätzliche Intensitätsfilter eingesetzt werden. Diese Isolierung wäre ähnlich dem betreffenden Peak-Picking bei der klassischen 1H-NMR- Interpretation. An expert calculating the peaks of the target compounds by known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can isolate the peaks of the target compounds as needed, using additional intensity filters, if necessary. This isolation would be similar to peak picking in classical 1H NMR interpretation.

Weitere Details zu 1H-NMR-Peaklisten können der Research Disclosure Database Number 564025 entnommen werden. Further details on 1H NMR peaks can be found in Research Disclosure Database Number 564025.

1.1-1 : 1 H-NMR(400.0 MHz, CDCI3): 1.1-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6802 (1.8); 7.6740 (1.8); 7.2964 (0.8); 7.2754 (0.5); 7.2602 (23.1); 7.0199 (1.0); 6.9992 (1.8); 6.9785 (0.9); 6.6130 (0.9); 6.6070 (0.9); 2.7279 (0.6); 2.7182 (0.6); 1.8779 (16.0); 1.5524 (4.1); 0.7209 (0.8); 0.7173 (1.2); 0.7033δ = 7.6802 (1.8); 7.6740 (1.8); 7.2964 (0.8); 7.2754 (0.5); 7.2602 (23.1); 7.0199 (1.0); 6.9992 (1.8); 6.9785 (0.9); 6.6130 (0.9); 6.6070 (0.9); 2.7279 (0.6); 2.7182 (0.6); 1.8779 (16.0); 1.5524 (4.1); 0.7209 (0.8); 0.7173 (1.2); 0.7033

(1.0) ; 0.6993 (0.9); 0.4320 (0.7); 0.4291 (0.8); 0.4254 (0.8); 0.4193 (0.8); 0.4157 (0.8); -0.0002 (8.0) (1.0); 0.6993 (0.9); 0.4320 (0.7); 0.4291 (0.8); 0.4254 (0.8); 0.4193 (0.8); 0.4157 (0.8); -0.0002 (8.0)

1.1-3: 1 H-NMR(400.0 MHz, CDCI3):  1.1-3: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6820 (1.8); 7.6758 (1.8); 7.3203 (0.8); 7.2599 (24.7); 7.0398 (1.1); 7.0189 (2.0); 6.9980 (1.0); 6.6401 (1.0); 6.6343 (1.0); 5.2984 (2.9); 1.8800 (16.0); 1.5430 (1.5); 1.5290 (0.9); 1.5139 (1.6); 1.5080 (1.6); 1.4936 (0.8); 1.1740δ = 7.6820 (1.8); 7.6758 (1.8); 7.3203 (0.8); 7.2599 (24.7); 7.0398 (1.1); 7.0189 (2.0); 6.9980 (1.0); 6.6401 (1.0); 6.6343 (1.0); 5.2984 (2.9); 1.8800 (16.0); 1.5430 (1.5); 1.5290 (0.9); 1.5139 (1.6); 1.5080 (1.6); 1.4936 (0.8); 1.1740

(0.8); 1.1596 (1.6); 1.1536 (1.6); 1.1386 (0.6); -0.0002 (9.0) (0.8); 1.1596 (1.6); 1.1536 (1.6); 1.1386 (0.6); -0.0002 (9.0)

1.1-4: 1 H-NMR(400.0 MHz, CDCI3):  1.1-4: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7050 (2.0); 7.6989 (2.0); 7.6454 (0.5); 7.2968 (0.8); 7.2757 (0.6); 7.2599 (38.9); 7.0171 (1.1); 6.9963 (2.1); 6.9757 (1.0); 6.6272 (1.0); 6.6212 (1.0); 4.1238 (0.8); 4.1060 (2.7); 4.0881 (2.8); 4.0703 (0.9); 1.9058 (16.0); 1.5473δ = 7.7050 (2.0); 7.6989 (2.0); 7.6454 (0.5); 7.2968 (0.8); 7.2757 (0.6); 7.2599 (38.9); 7.0171 (1.1); 6.9963 (2.1); 6.9757 (1.0); 6.6272 (1.0); 6.6212 (1.0); 4.1238 (0.8); 4.1060 (2.7); 4.0881 (2.8); 4.0703 (0.9); 1.9058 (16.0); 1.5473

(7.1) ; 1.5206 (0.8); 1.5086 (2.0); 1.5004 (2.0); 1.4890 (0.8); 1.2159 (2.8); 1.1980 (5.8); 1.1802 (2.7); 1.0527 (0.8);(7.1); 1.5206 (0.8); 1.5086 (2.0); 1.5004 (2.0); 1.4890 (0.8); 1.2159 (2.8); 1.1980 (5.8); 1.1802 (2.7); 1.0527 (0.8);

1.0413 (2.0); 1.0331 (2.0); 1.0210 (0.7); -0.0002 (13.6) 1.0413 (2.0); 1.0331 (2.0); 1.0210 (0.7); -0.0002 (13.6)

1.1-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.1-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5805 (1.7); 7.5745 (1.7); 7.2725 (0.5); 7.2602 (23.6); 7.2425 (0.6); 7.2367 (0.6); 6.9742 (1.0); 6.9539 (1.7); 6.9335 (0.9); 6.5939 (1.0); 6.5882 (0.9); 3.5344 (1.0); 2.5701 (1.0); 1.8626 (16.0); 1.7226 (0.9); 1.7129 (1.3); 1.7055δ = 7.5805 (1.7); 7.5745 (1.7); 7.2725 (0.5); 7.2602 (23.6); 7.2425 (0.6); 7.2367 (0.6); 6.9742 (1.0); 6.9539 (1.7); 6.9335 (0.9); 6.5939 (1.0); 6.5882 (0.9); 3.5344 (1.0); 2.5701 (1.0); 1.8626 (16.0); 1.7226 (0.9); 1.7129 (1.3); 1.7055

(2.9); 1.6980 (1.4); 1.6885 (1.1); 1.5572 (6.1); -0.0002 (8.6) (2.9); 1.6980 (1.4); 1.6885 (1.1); 1.5572 (6.1); -0.0002 (8.6)

1.1-122: 1 H-NMR(400.0 MHz, CDCI3):  1.1-122: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6230 (1.8); 7.6169 (1.8); 7.2599 (31.5); 7.2326 (0.7); 6.9496 (0.9); 6.9289 (1.6); 6.9084 (0.8); 6.5488 (0.8); 6.5468 (0.6); 6.5447 (0.6); 6.5428 (0.9); 5.2984 (0.7); 3.7328 (0.8); 3.7143 (0.9); 3.6954 (0.8); 3.3922 (0.9); 3.3749δ = 7.6230 (1.8); 7.6169 (1.8); 7.2599 (31.5); 7.2326 (0.7); 6.9496 (0.9); 6.9289 (1.6); 6.9084 (0.8); 6.5488 (0.8); 6.5468 (0.6); 6.5447 (0.6); 6.5428 (0.9); 5.2984 (0.7); 3.7328 (0.8); 3.7143 (0.9); 3.6954 (0.8); 3.3922 (0.9); 3.3749

(1.9); 3.3578 (1.0); 2.1509 (0.8); 2.1320 (0.9); 2.1137 (0.8); 1.8867 (16.0); 1.5528 (8.1); -0.0002 (11.3) (1.9); 3.3578 (1.0); 2.1509 (0.8); 2.1320 (0.9); 2.1137 (0.8); 1.8867 (16.0); 1.5528 (8.1); -0.0002 (11.3)

1.1-124: 1 H-NMR(400.0 MHz, CDCI3):  1.1-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5330 (1.8); 7.5270 (1.8); 7.2602 (27.6); 6.9787 (0.9); 6.9582 (1.6); 6.9377 (0.8); 6.6079 (0.8); 6.6020 (0.8);δ = 7.5330 (1.8); 7.5270 (1.8); 7.2602 (27.6); 6.9787 (0.9); 6.9582 (1.6); 6.9377 (0.8); 6.6079 (0.8); 6.6020 (0.8);

1.8623 (16.0); 1.5498 (7.3); 1.4964 (0.6); -0.0002 (10.1) 1.8623 (16.0); 1.5498 (7.3); 1.4964 (0.6); -0.0002 (10.1)

1.1-149: 1 H-NMR(400.0 MHz, CDCI3):  1.1-149: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6500 (1.9); 7.6439 (1.9); 7.2599 (27.0); 7.2435 (0.8); 6.9570 (1.0); 6.9365 (1.6); 6.9162 (0.8); 6.5542 (0.9); 6.5517 (0.8); 6.5483 (0.9); 5.7476 (0.6); 5.6889 (0.6); 5.2983 (1.0); 4.2078 (1.0); 4.2016 (1.3); 4.1951 (1.0); 3.5711δ = 7.6500 (1.9); 7.6439 (1.9); 7.2599 (27.0); 7.2435 (0.8); 6.9570 (1.0); 6.9365 (1.6); 6.9162 (0.8); 6.5542 (0.9); 6.5517 (0.8); 6.5483 (0.9); 5.7476 (0.6); 5.6889 (0.6); 5.2983 (1.0); 4.2078 (1.0); 4.2016 (1.3); 4.1951 (1.0); 3.5711

(1.0); 3.5650 (1.2); 3.5594 (1.0); 1.8964 (16.0); 1.5511 (3.7); -0.0002 (9.4) (1.0); 3.5650 (1.2); 3.5594 (1.0); 1.8964 (16.0); 1.5511 (3.7); -0.0002 (9.4)

1.1-152: 1 H-NMR(400.0 MHz, CDCI3):  1.1-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5669 (1.8); 7.5609 (1.8); 7.2713 (0.8); 7.2601 (27.6); 7.2503 (0.6); 6.9852 (0.9); 6.9646 (1.6); 6.9442 (0.8);δ = 7.5669 (1.8); 7.5609 (1.8); 7.2713 (0.8); 7.2601 (27.6); 7.2503 (0.6); 6.9852 (0.9); 6.9646 (1.6); 6.9442 (0.8);

6.6315 (0.9); 6.6294 (0.6); 6.6277 (0.6); 6.6256 (0.9); 1.8722 (16.0); 1.5480 (8.4); -0.0002 (9.9) 6.6315 (0.9); 6.6294 (0.6); 6.6277 (0.6); 6.6256 (0.9); 1.8722 (16.0); 1.5480 (8.4); -0.0002 (9.9)

1.1-167: 1 H-NMR(400.0 MHz, CDCI3):  1.1-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5376 (1.7); 7.5315 (1.7); 7.2604 (15.6); 6.9775 (0.9); 6.9569 (1.5); 6.9365 (0.8); 6.6171 (0.8); 6.6113 (0.8);δ = 7.5376 (1.7); 7.5315 (1.7); 7.2604 (15.6); 6.9775 (0.9); 6.9569 (1.5); 6.9365 (0.8); 6.6171 (0.8); 6.6113 (0.8);

1.8694 (16.0); 1.5593 (1.6); -0.0002 (5.6) 1.8694 (16.0); 1.5593 (1.6); -0.0002 (5.6)

1.1-170: 1 H-NMR(400.0 MHz, CDCI3):  1.1-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7243 (1.9); 7.7181 (1.9); 7.2849 (0.8); 7.2687 (0.5); 7.2599 (36.4); 7.2484 (0.6); 7.0104 (1.0); 6.9896 (1.8); 6.9690 (0.9); 6.6702 (0.9); 6.6641 (0.9); 3.9674 (2.6); 3.9533 (2.6); 3.6987 (9.7); 1.9288 (16.0); 1.5450 (14.3); -δ = 7.7243 (1.9); 7.7181 (1.9); 7.2849 (0.8); 7.2687 (0.5); 7.2599 (36.4); 7.2484 (0.6); 7.0104 (1.0); 6.9896 (1.8); 6.9690 (0.9); 6.6702 (0.9); 6.6641 (0.9); 3.9674 (2.6); 3.9533 (2.6); 3.6987 (9.7); 1.9288 (16.0); 1.5450 (14.3); -

0.0002 (13.1); -0.0085 (0.5) 0.0002 (13.1); -0.0085 (0.5)

1.1-171 : 1 H-NMR(400.0 MHz, CDCI3):  1.1-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6735 (1.0); 7.2811 (0.9); 7.2752 (0.9); 7.2601 (80.3); 7.2447 (0.8); 7.2392 (1.0); 7.2237 (0.5); 6.9962 (0.6); 6.9821 (2.3); 6.9617 (3.9); 6.9413 (2.0); 6.6420 (1.2); 5.2984 (2.0); 4.0707 (2.6); 3.7537 (4.2); 2.5331 (4.1); 1.8929 (16.0); 1.5444 (15.6); 0.0079 (0.9); -0.0002 (28.8); -0.0085 (0.9) 1.1-213: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.6735 (1.0); 7.2811 (0.9); 7.2752 (0.9); 7.2601 (80.3); 7.2447 (0.8); 7.2392 (1.0); 7.2237 (0.5); 6.9962 (0.6); 6.9821 (2.3); 6.9617 (3.9); 6.9413 (2.0); 6.6420 (1.2); 5.2984 (2.0); 4.0707 (2.6); 3.7537 (4.2); 2.5331 (4.1); 1.8929 (16.0); 1.5444 (15.6); 0.0079 (0.9); -0.0002 (28.8); -0.0085 (0.9) 1.1-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7005 (1.8); 7.6942 (1.9); 7.3170 (0.8); 7.2960 (0.5); 7.2598 (35.0); 7.0407 (1.0); 7.0196 (1.8); 6.9988 (0.9); 6.6665 (0.9); 6.6648 (0.6); 6.6621 (0.6); 6.6604 (0.9); 5.2984 (1.2); 4.1244 (3.4); 4.1101 (3.4); 1.9084 (16.0); 1.5410δ = 7.7005 (1.8); 7.6942 (1.9); 7.3170 (0.8); 7.2960 (0.5); 7.2598 (35.0); 7.0407 (1.0); 7.0196 (1.8); 6.9988 (0.9); 6.6665 (0.9); 6.6648 (0.6); 6.6621 (0.6); 6.6604 (0.9); 5.2984 (1.2); 4.1244 (3.4); 4.1101 (3.4); 1.9084 (16.0); 1.5410

(2.1); -0.0002 (12.7) (2.1); -0.0002 (12.7)

1.1-214: 1 H-NMR(400.0 MHz, CDCI3):  1.1-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5811 (1.5); 7.5750 (1.5); 7.2758 (0.8); 7.2599 (27.6); 7.2550 (1.0); 6.9866 (1.0); 6.9660 (1.6); 6.9456 (0.8);δ = 7.5811 (1.5); 7.5750 (1.5); 7.2758 (0.8); 7.2599 (27.6); 7.2550 (1.0); 6.9866 (1.0); 6.9660 (1.6); 6.9456 (0.8);

6.6529 (0.8); 6.6470 (0.8); 5.2985 (0.9); 1.8905 (16.0); 1.5431 (4.4); -0.0002 (9.8) 6.6529 (0.8); 6.6470 (0.8); 5.2985 (0.9); 1.8905 (16.0); 1.5431 (4.4); -0.0002 (9.8)

1.1-303: 1 H-NMR(400.0 MHz, CDCI3):  1.1-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6252 (1.7); 7.6191 (1.7); 7.2656 (0.7); 7.2599 (30.4); 7.2448 (0.7); 6.9597 (0.9); 6.9392 (1.5); 6.9187 (0.8); 6.5721 (0.8); 6.5696 (0.6); 6.5662 (0.8); 3.1633 (6.8); 2.9749 (3.9); 1.8634 (16.0); 1.5491 (11.6); -0.0002 (10.5) 1.1-353: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.6252 (1.7); 7.6191 (1.7); 7.2656 (0.7); 7.2599 (30.4); 7.2448 (0.7); 6.9597 (0.9); 6.9392 (1.5); 6.9187 (0.8); 6.5721 (0.8); 6.5696 (0.6); 6.5662 (0.8); 3.1633 (6.8); 2.9749 (3.9); 1.8634 (16.0); 1.5491 (11.6); -0.0002 (10.5) 1.1-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.9845 (0.5); 7.6932 (1.9); 7.6870 (2.0); 7.3130 (0.8); 7.2606 (16.1); 7.0329 (1.0); 7.0119 (1.9); 6.9912 (0.9); 6.6614 (0.9); 6.6598 (0.6); 6.6569 (0.6); 6.6553 (0.9); 4.0481 (0.6); 3.9302 (1.2); 3.9220 (0.8); 3.9193 (1.2); 3.9158 (0.6); 3.9080 (1.4); 3.6670 (0.6); 3.6557 (0.6); 3.6502 (0.7); 3.6450 (0.7); 3.6391 (0.5); 1.9240 (16.0); 1.5752 (1.9); -δ = 9.9845 (0.5); 7.6932 (1.9); 7.6870 (2.0); 7.3130 (0.8); 7.2606 (16.1); 7.0329 (1.0); 7.0119 (1.9); 6.9912 (0.9); 6.6614 (0.9); 6.6598 (0.6); 6.6569 (0.6); 6.6553 (0.9); 4.0481 (0.6); 3.9302 (1.2); 3.9220 (0.8); 3.9193 (1.2); 3.9158 (0.6); 3.9080 (1.4); 3.6670 (0.6); 3.6557 (0.6); 3.6502 (0.7); 3.6450 (0.7); 3.6391 (0.5); 1.9240 (16.0); 1.5752 (1.9); -

0.0002 (8.0) 0.0002 (8.0)

1.4-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.4-1: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5359 (0.7); 8.5244 (0.7); 7.6902 (1.6); 7.6839 (1.7); 7.5148 (0.5); 7.5113 (0.5); 7.4878 (0.5); 7.4844 (0.5); 7.3036 (0.5); 7.2939 (0.6); 7.2922 (0.6); 7.2826 (0.9); 7.2731 (0.5); 7.2713 (0.5); 7.2641 (7.4); 6.9472 (0.9); 6.9415 (1.4); 6.9357 (0.9); 2.6763 (0.6); 2.6674 (0.6); 1.9089 (16.0); 0.7088 (0.5); 0.7070 (0.8); 0.7035 (1.2); 0.7007 (0.6); 0.6893 (1.0); 0.6856 (0.9); 0.3954 (0.7); 0.3924 (0.8); 0.3889 (0.8); 0.3864 (0.7); 0.3827 (0.8); 0.3793 (0.8); -0.0002δ = 8.5359 (0.7); 8.5244 (0.7); 7.6902 (1.6); 7.6839 (1.7); 7.5148 (0.5); 7.5113 (0.5); 7.4878 (0.5); 7.4844 (0.5); 7.3036 (0.5); 7.2939 (0.6); 7.2922 (0.6); 7.2826 (0.9); 7.2731 (0.5); 7.2713 (0.5); 7.2641 (7.4); 6.9472 (0.9); 6.9415 (1.4); 6.9357 (0.9); 2.6763 (0.6); 2.6674 (0.6); 1.9089 (16.0); 0.7088 (0.5); 0.7070 (0.8); 0.7035 (1.2); 0.7007 (0.6); 0.6893 (1.0); 0.6856 (0.9); 0.3954 (0.7); 0.3924 (0.8); 0.3889 (0.8); 0.3864 (0.7); 0.3827 (0.8); 0.3793 (0.8); -0.0002

(2-9) (2-9)

1.4-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.4-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5466 (0.7); 8.5350 (0.7); 7.5676 (1.8); 7.5615 (1.9); 7.4838 (0.5); 7.4803 (0.5); 7.4568 (0.5); 7.4533 (0.5); 7.2714 (0.6); 7.2651 (8.2); 7.2620 (0.9); 7.2600 (0.7); 7.2505 (0.9); 6.9666 (0.8); 6.9600 (1.2); 6.9531 (0.8); 5.2989δ = 8.5466 (0.7); 8.5350 (0.7); 7.5676 (1.8); 7.5615 (1.9); 7.4838 (0.5); 7.4803 (0.5); 7.4568 (0.5); 7.4533 (0.5); 7.2714 (0.6); 7.2651 (8.2); 7.2620 (0.9); 7.2600 (0.7); 7.2505 (0.9); 6.9666 (0.8); 6.9600 (1.2); 6.9531 (0.8); 5.2989

(0.5); 3.5364 (0.8); 2.6152 (0.8); 1.9060 (16.0); 1.7004 (0.6); 1.6850 (1.0); 1.6709 (0.7); -0.0002 (3.0) (0.5); 3.5364 (0.8); 2.6152 (0.8); 1.9060 (16.0); 1.7004 (0.6); 1.6850 (1.0); 1.6709 (0.7); -0.0002 (3.0)

1.4-167: 1 H-NMR(400.0 MHz, CDCI3):  1.4-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5490 (0.7); 8.5375 (0.7); 7.5215 (1.8); 7.5154 (1.8); 7.4857 (0.5); 7.4823 (0.5); 7.2725 (0.6); 7.2656 (6.1); 7.2631 (0.8); 7.2611 (0.6); 7.2516 (0.8); 6.9766 (0.8); 6.9702 (1.0); 6.9694 (1.0); 6.9629 (0.8); 1.9144 (16.0); -0.0002δ = 8.5490 (0.7); 8.5375 (0.7); 7.5215 (1.8); 7.5154 (1.8); 7.4857 (0.5); 7.4823 (0.5); 7.2725 (0.6); 7.2656 (6.1); 7.2631 (0.8); 7.2611 (0.6); 7.2516 (0.8); 6.9766 (0.8); 6.9702 (1.0); 6.9694 (1.0); 6.9629 (0.8); 1.9144 (16.0); -0.0002

(2-4) (2-4)

1.4-167: 1 H-NMR(400.0 MHz, CDCI3):  1.4-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5500 (0.6); 8.5384 (0.6); 7.5213 (1.7); 7.5152 (1.7); 7.2624 (13.6); 7.2521 (0.8); 6.9768 (0.7); 6.9705 (0.9);δ = 8.5500 (0.6); 8.5384 (0.6); 7.5213 (1.7); 7.5152 (1.7); 7.2624 (13.6); 7.2521 (0.8); 6.9768 (0.7); 6.9705 (0.9);

6.9694 (0.9); 6.9631 (0.7); 1.9144 (16.0); -0.0002 (5.2) 6.9694 (0.9); 6.9631 (0.7); 1.9144 (16.0); -0.0002 (5.2)

1.4-170: 1 H-NMR(400.0 MHz, CDCI3):  1.4-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5421 (0.7); 8.5306 (0.7); 7.7524 (1.8); 7.7461 (1.9); 7.5079 (0.6); 7.5045 (0.6); 7.4810 (0.6); 7.4775 (0.5); 7.2968 (0.6); 7.2872 (0.6); 7.2854 (0.6); 7.2758 (1.0); 7.2635 (8.7); 6.9990 (1.0); 6.9927 (1.8); 6.9863 (1.0); 3.9579δ = 8.5421 (0.7); 8.5306 (0.7); 7.7524 (1.8); 7.7461 (1.9); 7.5079 (0.6); 7.5045 (0.6); 7.4810 (0.6); 7.4775 (0.5); 7.2968 (0.6); 7.2872 (0.6); 7.2854 (0.6); 7.2758 (1.0); 7.2635 (8.7); 6.9990 (1.0); 6.9927 (1.8); 6.9863 (1.0); 3.9579

(2.6) ; 3.9442 (2.6); 3.6789 (10.0); 1.9638 (16.0); -0.0002 (3.3) (2.6); 3.9442 (2.6); 3.6789 (10.0); 1.9638 (16.0); -0.0002 (3.3)

1.4- 171 : 1 H-NMR(400.0 MHz, CDCI3):  1.4-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5633 (1.0); 8.5594 (1.7); 8.5556 (1.0); 8.5517 (1.1); 8.5479 (1.7); 8.5441 (1.0); 7.7175 (1.1); 7.7131 (1.1); 7.5141 (0.9); 7.5107 (1.0); 7.4933 (1.1); 7.4899 (1.2); 7.4871 (1.0); 7.4836 (1.0); 7.4662 (1.1); 7.4628 (1.1); 7.2788 (1.0); 7.2689 (1.5); 7.2673 (1.6); 7.2606 (73.9); 7.2482 (1.0); 7.2467 (1.0); 7.2369 (0.8); 7.0010 (1.0); 6.9967 (1.1); 4.0731 (3.0); 3.7641 (4.9); 2.5539 (4.8); 1.9364 (16.0); 1.9145 (0.6); 0.0080 (0.8); -0.0002 (28.2); -0.0085 (0.9)δ = 8.5633 (1.0); 8.5594 (1.7); 8.5556 (1.0); 8.5517 (1.1); 8.5479 (1.7); 8.5441 (1.0); 7.7175 (1.1); 7.7131 (1.1); 7.5141 (0.9); 7.5107 (1.0); 7.4933 (1.1); 7.4899 (1.2); 7.4871 (1.0); 7.4836 (1.0); 7.4662 (1.1); 7.4628 (1.1); 7.2788 (1.0); 7.2689 (1.5); 7.2673 (1.6); 7.2606 (73.9); 7.2482 (1.0); 7.2467 (1.0); 7.2369 (0.8); 7.0010 (1.0); 6.9967 (1.1); 4.0731 (3.0); 3.7641 (4.9); 2.5539 (4.8); 1.9364 (16.0); 1.9145 (0.6); 0.0080 (0.8); -0.0002 (28.2); -0.0085 (0.9)

1.5- 1 : 1 H-NMR(400.0 MHz, CDCI3): 1.5- 1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6028 (0.9); 8.5991 (0.9); 8.5913 (0.9); 8.5875 (0.9); 7.8234 (1.0); 7.8196 (1.0); 7.8031 (1.1); 7.7993 (1.1); 7.6754 (2.0); 7.6692 (2.1); 7.2610 (19.7); 7.2444 (1.1); 7.2329 (1.1); 7.2242 (1.0); 7.2126 (1.0); 6.9123 (1.9); 6.9061 (1.8); 2.6749 (0.6); 2.6664 (0.6); 1.8946 (16.0); 0.7143 (0.5); 0.7124 (0.8); 0.7089 (1.2); 0.7061 (0.5); 0.6961 (0.8); 0.6948 (1.0); 0.6910 (0.9); 0.4017 (0.7); 0.3988 (0.9); 0.3953 (0.8); 0.3927 (0.7); 0.3890 (0.9); 0.3856 (0.8); -0.0002δ = 8.6028 (0.9); 8.5991 (0.9); 8.5913 (0.9); 8.5875 (0.9); 7.8234 (1.0); 7.8196 (1.0); 7.8031 (1.1); 7.7993 (1.1); 7.6754 (2.0); 7.6692 (2.1); 7.2610 (19.7); 7.2444 (1.1); 7.2329 (1.1); 7.2242 (1.0); 7.2126 (1.0); 6.9123 (1.9); 6.9061 (1.8); 2.6749 (0.6); 2.6664 (0.6); 1.8946 (16.0); 0.7143 (0.5); 0.7124 (0.8); 0.7089 (1.2); 0.7061 (0.5); 0.6961 (0.8); 0.6948 (1.0); 0.6910 (0.9); 0.4017 (0.7); 0.3988 (0.9); 0.3953 (0.8); 0.3927 (0.7); 0.3890 (0.9); 0.3856 (0.8); -0.0002

(7-0) (7-0)

I.5-2: 1 H-NMR(400.0 MHz, CDCI3):  I.5-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6044 (0.9); 8.6007 (0.9); 8.5929 (0.9); 8.5891 (0.9); 7.8290 (1.0); 7.8252 (1.0); 7.8087 (1.1); 7.8049 (1.1); 7.6610 (2.0); 7.6548 (2.0); 7.2613 (16.6); 7.2461 (1.2); 7.2346 (1.1); 7.2258 (1.1); 7.2143 (1.0); 6.9020 (1.8); 6.8959 (1.8); 1.8697 (16.0); 1.5849 (1.4); 1.2991 (6.1); 0.6146 (1.2); 0.6037 (1.2); 0.5746 (1.4); 0.5646 (1.2); 0.5628 (1.2); -δ = 8.6044 (0.9); 8.6007 (0.9); 8.5929 (0.9); 8.5891 (0.9); 7.8290 (1.0); 7.8252 (1.0); 7.8087 (1.1); 7.8049 (1.1); 7.6610 (2.0); 7.6548 (2.0); 7.2613 (16.6); 7.2461 (1.2); 7.2346 (1.1); 7.2258 (1.1); 7.2143 (1.0); 6.9020 (1.8); 6.8959 (1.8); 1.8697 (16.0); 1.5849 (1.4); 1.2991 (6.1); 0.6146 (1.2); 0.6037 (1.2); 0.5746 (1.4); 0.5646 (1.2); 0.5628 (1.2); -

0.0002 (5.6) 0.0002 (5.6)

I.5-3: 1 H-NMR(400.0 MHz, CDCI3):  I.5-3: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6100 (0.8); 8.6063 (0.9); 8.5985 (0.9); 8.5948 (0.9); 7.8421 (0.9); 7.8384 (0.9); 7.8218 (1.0); 7.8181 (1.0); 7.6807 (1.8); 7.6744 (1.9); 7.2692 (1.1); 7.2611 (13.1); 7.2489 (0.9); 7.2374 (0.9); 6.9322 (1.7); 6.9260 (1.7); 1.8953 (16.0); 1.6038 (2.0); 1.5205 (0.7); 1.5055 (1.6); 1.4996 (1.7); 1.4853 (0.8); 1.1592 (0.8); 1.1448 (1.6); 1.1389 (1.6);δ = 8.6100 (0.8); 8.6063 (0.9); 8.5985 (0.9); 8.5948 (0.9); 7.8421 (0.9); 7.8384 (0.9); 7.8218 (1.0); 7.8181 (1.0); 7.6807 (1.8); 7.6744 (1.9); 7.2692 (1.1); 7.2611 (13.1); 7.2489 (0.9); 7.2374 (0.9); 6.9322 (1.7); 6.9260 (1.7); 1.8953 (16.0); 1.6038 (2.0); 1.5205 (0.7); 1.5055 (1.6); 1.4996 (1.7); 1.4853 (0.8); 1.1592 (0.8); 1.1448 (1.6); 1.1389 (1.6);

1.1239 (0.7); -0.0002 (4.7) 1.1239 (0.7); -0.0002 (4.7)

I.5-9: 1 H-NMR(400.0 MHz, CDCI3):  I.5-9: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6055 (0.9); 8.6018 (0.9); 8.5940 (0.9); 8.5902 (0.9); 7.8339 (0.9); 7.8302 (0.9); 7.8136 (1.0); 7.8099 (0.9); 7.6951 (2.1); 7.6889 (2.1); 7.2609 (23.2); 7.2548 (1.4); 7.2432 (1.0); 7.2344 (0.9); 7.2229 (0.9); 6.9292 (1.7); 6.9231δ = 8.6055 (0.9); 8.6018 (0.9); 8.5940 (0.9); 8.5902 (0.9); 7.8339 (0.9); 7.8302 (0.9); 7.8136 (1.0); 7.8099 (0.9); 7.6951 (2.1); 7.6889 (2.1); 7.2609 (23.2); 7.2548 (1.4); 7.2432 (1.0); 7.2344 (0.9); 7.2229 (0.9); 6.9292 (1.7); 6.9231

(1.7) ; 3.2224 (11.6); 1.9113 (16.0); 1.5787 (1.2); 1.0742 (0.6); 1.0608 (1.5); 1.0555 (1.6); 1.0531 (1.0); 1.0423 (0.8); 0.8473 (0.8); 0.8364 (1.0); 0.8338 (1.6); 0.8287 (1.5); 0.8151 (0.6); -0.0002 (8.6) 1.5-10: 1 H-NMR(400.0 MHz, CDCI3): (1.7); 3.2224 (11.6); 1.9113 (16.0); 1.5787 (1.2); 1.0742 (0.6); 1.0608 (1.5); 1.0555 (1.6); 1.0531 (1.0); 1.0423 (0.8); 0.8473 (0.8); 0.8364 (1.0); 0.8338 (1.6); 0.8287 (1.5); 0.8151 (0.6); -0.0002 (8.6) 1.5-10: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6049 (0.9); 8.6011 (1.0); 8.5933 (1.0); 8.5896 (1.0); 7.8317 (1.2); 7.8279 (1.2); 7.8114 (1.1); 7.8076 (1.1); 7.6861 (2.0); 7.6799 (2.1); 7.2604 (38.4); 7.2540 (1.3); 7.2524 (1.9); 7.2493 (0.7); 7.2477 (0.6); 7.2469 (0.5); 7.2409 (1.3); 7.2321 (1.2); 7.2206 (1.1); 6.9272 (1.8); 6.9210 (1.8); 3.5298 (0.8); 3.5121 (2.5); 3.4944 (2.6); 3.4767 (0.8); 1.9032 (16.0); 1.5614 (2.8); 1.0985 (2.6); 1.0808 (5.4); 1.0732 (0.9); 1.0631 (2.8); 1.0597 (1.8); 1.0543 (1.8); 1.0412δ = 8.6049 (0.9); 8.6011 (1.0); 8.5933 (1.0); 8.5896 (1.0); 7.8317 (1.2); 7.8279 (1.2); 7.8114 (1.1); 7.8076 (1.1); 7.6861 (2.0); 7.6799 (2.1); 7.2604 (38.4); 7.2540 (1.3); 7.2524 (1.9); 7.2493 (0.7); 7.2477 (0.6); 7.2469 (0.5); 7.2409 (1.3); 7.2321 (1.2); 7.2206 (1.1); 6.9272 (1.8); 6.9210 (1.8); 3.5298 (0.8); 3.5121 (2.5); 3.4944 (2.6); 3.4767 (0.8); 1.9032 (16.0); 1.5614 (2.8); 1.0985 (2.6); 1.0808 (5.4); 1.0732 (0.9); 1.0631 (2.8); 1.0597 (1.8); 1.0543 (1.8); 1.0412

(1.0); 0.8476 (0.8); 0.8343 (1.6); 0.8291 (1.6); 0.8155 (0.7); -0.0002 (14.8); -0.0085 (0.6) (1.0); 0.8476 (0.8); 0.8343 (1.6); 0.8291 (1.6); 0.8155 (0.7); -0.0002 (14.8); -0.0085 (0.6)

1.5-12: 1 H-NMR(400.0 MHz, CDCI3):  1.5-12: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5928 (1.8); 8.5894 (1.7); 8.5813 (1.9); 8.5778 (1.8); 7.7887 (1.8); 7.7853 (1.7); 7.7685 (2.0); 7.7650 (1.8); 7.4990 (1.3); 7.2616 (24.7); 7.2059 (1.8); 7.1943 (1.8); 7.1856 (1.7); 7.1741 (1.7); 6.9052 (2.0); 6.8999 (2.1); 2.5342 (0.6); 1.9026 (16.0); 1.5845 (4.2); 1.2564 (0.5); 0.7104 (0.6); 0.5983 (0.8); 0.5856 (2.7); 0.5798 (2.6); 0.5751 (2.6);δ = 8.5928 (1.8); 8.5894 (1.7); 8.5813 (1.9); 8.5778 (1.8); 7.7887 (1.8); 7.7853 (1.7); 7.7685 (2.0); 7.7650 (1.8); 7.4990 (1.3); 7.2616 (24.7); 7.2059 (1.8); 7.1943 (1.8); 7.1856 (1.7); 7.1741 (1.7); 6.9052 (2.0); 6.8999 (2.1); 2.5342 (0.6); 1.9026 (16.0); 1.5845 (4.2); 1.2564 (0.5); 0.7104 (0.6); 0.5983 (0.8); 0.5856 (2.7); 0.5798 (2.6); 0.5751 (2.6);

0.5576 (0.8); -0.0002 (8.7) 0.5576 (0.8); -0.0002 (8.7)

1.5-17: 1 H-NMR(400.0 MHz, CDCI3):  1.5-17: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5969 (1.0); 8.5931 (1.0); 8.5853 (1.0); 8.5815 (1.0); 7.8335 (1.0); 7.8297 (1.1); 7.8132 (1.2); 7.8094 (1.1); 7.6787 (2.4); 7.6725 (2.3); 7.2617 (15.2); 7.2500 (1.2); 7.2384 (1.2); 7.2297 (1.1); 7.2181 (1.0); 6.9315 (2.0); 6.9254δ = 8.5969 (1.0); 8.5931 (1.0); 8.5853 (1.0); 8.5815 (1.0); 7.8335 (1.0); 7.8297 (1.1); 7.8132 (1.2); 7.8094 (1.1); 7.6787 (2.4); 7.6725 (2.3); 7.2617 (15.2); 7.2500 (1.2); 7.2384 (1.2); 7.2297 (1.1); 7.2181 (1.0); 6.9315 (2.0); 6.9254

(2.0) ; 5.2984 (0.5); 2.7756 (4.6); 1.8898 (16.0); 1.6090 (0.9); 0.8780 (0.7); 0.8746 (1.6); 0.8691 (1.0); 0.8613 (1.1);(2.0); 5.2984 (0.5); 2.7756 (4.6); 1.8898 (16.0); 1.6090 (0.9); 0.8780 (0.7); 0.8746 (1.6); 0.8691 (1.0); 0.8613 (1.1);

0.8568 (0.7); 0.8291 (0.7); 0.8244 (0.9); 0.8114 (1.4); -0.0002 (5.3) 0.8568 (0.7); 0.8291 (0.7); 0.8244 (0.9); 0.8114 (1.4); -0.0002 (5.3)

1.5-19: 1 H-NMR(400.0 MHz, CDCI3):  1.5-19: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6084 (1.2); 8.6047 (1.4); 8.5969 (1.3); 8.5931 (1.4); 7.8418 (1.0); 7.8381 (1.1); 7.8215 (1.2); 7.8178 (1.2); 7.6814 (2.9); 7.6752 (3.0); 7.2601 (76.8); 7.2456 (1.8); 7.2340 (1.4); 7.2272 (0.6); 6.9217 (2.3); 6.9155 (2.3); 3.0147 (0.8); 3.0066 (0.8); 2.9946 (0.5); 1.9293 (1.0); 1.9200 (1.0); 1.8917 (16.0); 1.6148 (0.5); 1.5538 (8.0); 1.2185 (0.9);δ = 8.6084 (1.2); 8.6047 (1.4); 8.5969 (1.3); 8.5931 (1.4); 7.8418 (1.0); 7.8381 (1.1); 7.8215 (1.2); 7.8178 (1.2); 7.6814 (2.9); 7.6752 (3.0); 7.2601 (76.8); 7.2456 (1.8); 7.2340 (1.4); 7.2272 (0.6); 6.9217 (2.3); 6.9155 (2.3); 3.0147 (0.8); 3.0066 (0.8); 2.9946 (0.5); 1.9293 (1.0); 1.9200 (1.0); 1.8917 (16.0); 1.6148 (0.5); 1.5538 (8.0); 1.2185 (0.9);

1.2139 (0.5); 1.2026 (0.6); 1.1983 (0.9); 1.0953 (1.1); 0.0080 (1.0); -0.0002 (30.1); -0.0085 (1.2) 1.2139 (0.5); 1.2026 (0.6); 1.1983 (0.9); 1.0953 (1.1); 0.0080 (1.0); -0.0002 (30.1); -0.0085 (1.2)

I.5-56: 1 H-NMR(400.0 MHz, CDCI3):  I.5-56: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5955 (1.0); 8.5918 (1.1); 8.5840 (1.1); 8.5803 (1.1); 7.8857 (0.6); 7.8257 (1.1); 7.8219 (1.1); 7.8054 (1.2); 7.8016 (1.2); 7.7179 (2.1); 7.7116 (2.2); 7.2635 (12.7); 7.2496 (1.3); 7.2408 (1.2); 7.2293 (1.1); 7.0067 (2.0); 7.0004δ = 8.5955 (1.0); 8.5918 (1.1); 8.5840 (1.1); 8.5803 (1.1); 7.8857 (0.6); 7.8257 (1.1); 7.8219 (1.1); 7.8054 (1.2); 7.8016 (1.2); 7.7179 (2.1); 7.7116 (2.2); 7.2635 (12.7); 7.2496 (1.3); 7.2408 (1.2); 7.2293 (1.1); 7.0067 (2.0); 7.0004

(2.1) ; 5.2992 (8.4); 3.9960 (0.9); 3.9753 (0.6); 3.9647 (1.1); 3.9542 (0.5); 3.7940 (0.6); 3.7829 (1.0); 3.7719 (0.6); 3.7518 (0.8); 3.7449 (0.9); 3.7288 (0.8); 3.7216 (1.0); 3.6911 (1.0); 3.6850 (0.8); 3.6658 (0.7); 3.6596 (1.0); 3.6541 (0.6); 3.6349 (0.6); 3.6286 (0.6); 2.3339 (0.6); 2.3002 (0.7); 2.0072 (0.6); 1.9788 (0.6); 1.9735 (0.8); 1.9685 (0.6); 1.9341 (16.0); 1.8983 (0.6); 1.8879 (0.5); 1.8753 (0.6); 1.8648 (0.9); 1.8544 (0.6); 1.8416 (0.5); 1.8313 (0.5); 1.7876(2.1); 5.2992 (8.4); 3.9960 (0.9); 3.9753 (0.6); 3.9647 (1.1); 3.9542 (0.5); 3.7940 (0.6); 3.7829 (1.0); 3.7719 (0.6); 3.7518 (0.8); 3.7449 (0.9); 3.7288 (0.8); 3.7216 (1.0); 3.6911 (1.0); 3.6850 (0.8); 3.6658 (0.7); 3.6596 (1.0); 3.6541 (0.6); 3.6349 (0.6); 3.6286 (0.6); 2.3339 (0.6); 2.3002 (0.7); 2.0072 (0.6); 1.9788 (0.6); 1.9735 (0.8); 1.9685 (0.6); 1.9341 (16.0); 1.8983 (0.6); 1.8879 (0.5); 1.8753 (0.6); 1.8648 (0.9); 1.8544 (0.6); 1.8416 (0.5); 1.8313 (0.5); 1.7876

(0.8); 1.7772 (0.7); 1.7619 (0.7); 1.7525 (0.9); 1.7434 (0.6); 1.7280 (0.5); 1.7176 (0.6); -0.0002 (4.6) (0.8); 1.7772 (0.7); 1.7619 (0.7); 1.7525 (0.9); 1.7434 (0.6); 1.7280 (0.5); 1.7176 (0.6); -0.0002 (4.6)

I.5-63: 1 H-NMR(400.0 MHz, CDCI3):  I.5-63: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.8149 (0.8); 8.6559 (1.0); 8.6445 (1.1); 7.9557 (1.5); 7.8682 (1.0); 7.8479 (1.1); 7.7630 (1.7); 7.7571 (1.9); 7.7470 (0.6); 7.7421 (0.9); 7.7285 (0.6); 7.7235 (0.9); 7.7192 (0.6); 7.3785 (1.3); 7.3592 (2.6); 7.2974 (0.8); 7.2859 (0.9); 7.2770 (0.9); 7.2612 (7.4); 7.0316 (1.6); 7.0258 (1.7); 5.2979 (0.5); 2.0059 (16.0); 1.6064 (0.8); -0.0002 (2.5) I.5-73: 1 H-NMR(400.0 MHz, CDCI3): δ = 9.8149 (0.8); 8.6559 (1.0); 8.6445 (1.1); 7.9557 (1.5); 7.8682 (1.0); 7.8479 (1.1); 7.7630 (1.7); 7.7571 (1.9); 7.7470 (0.6); 7.7421 (0.9); 7.7285 (0.6); 7.7235 (0.9); 7.7192 (0.6); 7.3785 (1.3); 7.3592 (2.6); 7.2974 (0.8); 7.2859 (0.9); 7.2770 (0.9); 7.2612 (7.4); 7.0316 (1.6); 7.0258 (1.7); 5.2979 (0.5); 2.0059 (16.0); 1.6064 (0.8); -0.0002 (2.5) I.5-73: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6262 (0.9); 8.6225 (1.0); 8.6146 (1.0); 8.6109 (1.0); 7.8632 (0.9); 7.8595 (0.9); 7.8430 (1.0); 7.8392 (1.0); 7.7532 (1.9); 7.7469 (2.0); 7.4429 (1.8); 7.4339 (1.8); 7.2678 (1.4); 7.2597 (49.6); 7.2477 (1.2); 7.2360 (1.0); 6.9859δ = 8.6262 (0.9); 8.6225 (1.0); 8.6146 (1.0); 8.6109 (1.0); 7.8632 (0.9); 7.8595 (0.9); 7.8430 (1.0); 7.8392 (1.0); 7.7532 (1.9); 7.7469 (2.0); 7.4429 (1.8); 7.4339 (1.8); 7.2678 (1.4); 7.2597 (49.6); 7.2477 (1.2); 7.2360 (1.0); 6.9859

(1.8); 6.9795 (3.8); 6.9704 (2.0); 2.0272 (16.0); 0.0079 (0.8); -0.0002 (18.7); -0.0084 (0.5) (1.8); 6.9795 (3.8); 6.9704 (2.0); 2.0272 (16.0); 0.0079 (0.8); -0.0002 (18.7); -0.0084 (0.5)

1.5-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.5-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6064 (1.0); 8.6026 (1.0); 8.5948 (1.0); 8.5911 (0.9); 7.7983 (1.0); 7.7945 (1.0); 7.7781 (1.1); 7.7743 (1.0); 7.5675 (2.0); 7.5615 (2.0); 7.2651 (15.1); 7.2199 (1.1); 7.2083 (1.1); 7.1997 (1.0); 7.1881 (1.0); 6.9206 (1.8); 6.9146δ = 8.6064 (1.0); 8.6026 (1.0); 8,55948 (1.0); 8.5911 (0.9); 7.7983 (1.0); 7.7945 (1.0); 7.7781 (1.1); 7.7743 (1.0); 7.5675 (2.0); 7.5615 (2.0); 7.2651 (15.1); 7.2199 (1.1); 7.2083 (1.1); 7.1997 (1.0); 7.1881 (1.0); 6.9206 (1.8); 6.9146

(1.8) ; 3.5356 (1.1); 2.6161 (1.2); 2.5998 (0.5); 1.8892 (16.0); 1.7064 (1.4); 1.6984 (1.8); 1.6924 (1.4); 1.6816 (0.7);(1.8); 3.5356 (1.1); 2.6161 (1.2); 2.5998 (0.5); 1.8892 (16.0); 1.7064 (1.4); 1.6984 (1.8); 1.6924 (1.4); 1.6816 (0.7);

1.6763 (0.5); -0.0002 (5.4) 1.6763 (0.5); -0.0002 (5.4)

1.5-106: 1 H-NMR(400.0 MHz, CDCI3):  1.5-106: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5954 (4.8); 8.5839 (5.0); 7.7906 (4.4); 7.7705 (4.7); 7.5797 (2.9); 7.5669 (3.2); 7.2629 (52.6); 7.2183 (4.1); 7.2067 (4.1); 7.1981 (4.0); 7.1865 (3.8); 6.9159 (3.4); 5.2990 (1.6); 3.8106 (1.4); 3.7893 (2.7); 3.7720 (1.6); 3.7399 (0.5); 3.6780 (10.7); 3.6426 (1.7); 3.6115 (10.1); 3.0794 (0.7); 3.0642 (0.9); 3.0501 (0.9); 3.0369 (1.0); 2.9551 (1.0); 2.9240 (1.0); 2.9053 (1.6); 2.8828 (2.8); 2.8434 (1.3); 2.8255 (0.7); 2.7548 (1.0); 2.7296 (1.0); 2.7106 (0.7); 2.6252 (0.5); 2.6073 (1.0); 2.5816 (0.9); 2.0433 (2.2); 2.0231 (1.8); 2.0077 (2.6); 1.9932 (3.2); 1.9769 (2.9); 1.9631 (1.9); 1.9147 (9.0); 1.8780 (16.0); 1.6103 (4.1); 1.2844 (0.8); 1.2766 (0.7); 1.2568 (3.3); 1.2409 (0.7); 0.8803 (0.5); -0.0002δ = 8.5954 (4.8); 8.5839 (5.0); 7.7906 (4.4); 7.7705 (4.7); 7.5797 (2.9); 7.5669 (3.2); 7.2629 (52.6); 7.2183 (4.1); 7.2067 (4.1); 7.1981 (4.0); 7.1865 (3.8); 6.9159 (3.4); 5.2990 (1.6); 3.8106 (1.4); 3.7893 (2.7); 3.7720 (1.6); 3.7399 (0.5); 3.6780 (10.7); 3.6426 (1.7); 3.6115 (10.1); 3.0794 (0.7); 3.0642 (0.9); 3.0501 (0.9); 3.0369 (1.0); 2.9551 (1.0); 2.9240 (1.0); 2.9053 (1.6); 2.8828 (2.8); 2.8434 (1.3); 2.8255 (0.7); 2.7548 (1.0); 2.7296 (1.0); 2.7106 (0.7); 2.6252 (0.5); 2.6073 (1.0); 2.5816 (0.9); 2.0433 (2.2); 2.0231 (1.8); 2.0077 (2.6); 1.9932 (3.2); 1.9769 (2.9); 1.9631 (1.9); 1.9147 (9.0); 1.8780 (16.0); 1.6103 (4.1); 1.2844 (0.8); 1.2766 (0.7); 1.2568 (3.3); 1.2409 (0.7); 0.8803 (0.5); -0.0002

(17-7) (17-7)

1.5-124: 1 H-NMR(400.0 MHz, CDCI3):  1.5-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6121 (0.8); 8.6083 (0.9); 8.6005 (0.8); 8.5968 (0.9); 7.7959 (0.8); 7.7921 (0.9); 7.7757 (0.9); 7.7719 (0.9); 7.5117 (1.7); 7.5057 (1.8); 7.2640 (6.9); 7.2126 (0.9); 7.2010 (0.9); 7.1924 (0.8); 7.1808 (0.8); 6.9354 (1.6); 6.9294δ = 8.6121 (0.8); 8.6083 (0.9); 8.6005 (0.8); 8.5968 (0.9); 7.7959 (0.8); 7.7921 (0.9); 7.7757 (0.9); 7.7719 (0.9); 7.5117 (1.7); 7.5057 (1.8); 7.2640 (6.9); 7.2126 (0.9); 7.2010 (0.9); 7.1924 (0.8); 7.1808 (0.8); 6.9354 (1.6); 6.9294

(1.6); 1.8873 (16.0); 1.6255 (1.2); 1.5104 (0.8); 1.4977 (0.8); -0.0002 (2.5) (1.6); 1.8873 (16.0); 1.6255 (1.2); 1.5104 (0.8); 1.4977 (0.8); -0.0002 (2.5)

1.5-134: 1 H-NMR(400.0 MHz, CDCI3):  1.5-134: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6127 (1.0); 8.6090 (1.0); 8.6011 (1.1); 8.5974 (1.0); 7.7996 (1.0); 7.7959 (1.0); 7.7794 (1.2); 7.7756 (1.1); 7.5057 (2.3); 7.4997 (2.3); 7.2612 (25.6); 7.2149 (1.1); 7.2034 (1.1); 7.1947 (1.1); 7.1831 (1.0); 6.9378 (1.9); 6.9318δ = 8.6127 (1.0); 8.6090 (1.0); 8.6011 (1.1); 8,55974 (1.0); 7.7996 (1.0); 7.7959 (1.0); 7.7794 (1.2); 7.7756 (1.1); 7.5057 (2.3); 7.4997 (2.3); 7.2612 (25.6); 7.2149 (1.1); 7.2034 (1.1); 7.1947 (1.1); 7.1831 (1.0); 6.9378 (1.9); 6.9318

(1.9) ; 2.6238 (0.5); 2.6173 (0.6); 2.5911 (0.9); 2.5858 (0.9); 2.5592 (0.6); 2.5526 (0.5); 1.8835 (16.0); 1.5803 (1.0);(1.9); 2.6238 (0.5); 2.6173 (0.6); 2.5911 (0.9); 2.5858 (0.9); 2.5592 (0.6); 2.5526 (0.5); 1.8835 (16.0); 1.5803 (1.0);

0.8632 (3.6); 0.8471 (3.4); -0.0002 (9.6) 0.8632 (3.6); 0.8471 (3.4); -0.0002 (9.6)

1.5-137: 1 H-NMR(400.0 MHz, CDCI3):  1.5-137: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6099 (0.9); 8.6062 (0.9); 8.5983 (0.9); 8.5946 (0.9); 7.8089 (0.8); 7.8052 (0.9); 7.7886 (0.9); 7.7849 (0.9); 7.5490 (1.8); 7.5429 (1.9); 7.2600 (57.0); 7.2334 (1.0); 7.2219 (0.9); 7.2132 (0.8); 7.2016 (0.8); 6.9732 (1.6); 6.9672δ = 8.6099 (0.9); 8.6062 (0.9); 8.5983 (0.9); 8.5946 (0.9); 7.8089 (0.8); 7.8052 (0.9); 7.7886 (0.9); 7.7849 (0.9); 7.5490 (1.8); 7.5429 (1.9); 7.2600 (57.0); 7.2334 (1.0); 7.2219 (0.9); 7.2132 (0.8); 7.2016 (0.8); 6.9732 (1.6); 6.9672

(1.6) ; 1.9022 (16.0); 1.8879 (1.1); 1.5496 (3.8); 0.0079 (0.9); -0.0002 (22.0); -0.0085 (0.9) (1.6); 1.9022 (16.0); 1.8879 (1.1); 1.5496 (3.8); 0.0079 (0.9); -0.0002 (22.0); -0.0085 (0.9)

1.5-152: 1 H-NMR(400.0 MHz, CDCI3):  1.5-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6103 (0.9); 8.6065 (0.9); 8.5987 (0.9); 8.5950 (0.9); 7.8021 (0.9); 7.7983 (0.9); 7.7818 (1.0); 7.7781 (1.0); 7.5467 (1.8); 7.5407 (1.9); 7.2638 (7.3); 7.2276 (1.0); 7.2160 (1.0); 7.2074 (0.9); 7.1958 (0.9); 6.9601 (1.7); 6.9540δ = 8.6103 (0.9); 8.6065 (0.9); 8.5987 (0.9); 8.5950 (0.9); 7.8021 (0.9); 7.7983 (0.9); 7.7818 (1.0); 7.7781 (1.0); 7.5467 (1.8); 7.5407 (1.9); 7.2638 (7.3); 7.2276 (1.0); 7.2160 (1.0); 7.2074 (0.9); 7.1958 (0.9); 6.9601 (1.7); 6.9540

(1.7) ; 5.2987 (1.4); 1.8972 (16.0); -0.0002 (2.6) 1.5-166: 1 H-NMR(400.0 MHz, CDCI3): (1.7); 5.2987 (1.4); 1.8972 (16.0); -0.0002 (2.6) 1.5-166: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6145 (0.9); 8.6107 (0.9); 8.6029 (0.9); 8.5992 (0.9); 7.8294 (1.0); 7.8257 (0.9); 7.8091 (1.0); 7.8054 (1.0); 7.7007 (1.8); 7.6945 (1.9); 7.2614 (15.8); 7.2488 (1.0); 7.2373 (1.0); 7.2285 (0.9); 7.2170 (0.9); 6.9354 (1.7); 6.9292δ = 8.6145 (0.9); 8.6107 (0.9); 8.6029 (0.9); 8.5992 (0.9); 7.8294 (1.0); 7.8257 (0.9); 7.8091 (1.0); 7.8054 (1.0); 7.7007 (1.8); 7.6945 (1.9); 7.2614 (15.8); 7.2488 (1.0); 7.2373 (1.0); 7.2285 (0.9); 7.2170 (0.9); 6.9354 (1.7); 6.9292

(1.7); 2.7385 (5.1); 2.7264 (5.1); 1.9214 (16.0); 1.5939 (1.2); -0.0002 (5.6) (1.7); 2.7385 (5.1); 2.7264 (5.1); 1.9214 (16.0); 1.5939 (1.2); -0.0002 (5.6)

1.5-167: 1 H-NMR(400.0 MHz, CDCI3):  1.5-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6121 (0.9); 8.6084 (0.9); 8.6005 (0.9); 8.5968 (0.9); 7.8004 (1.0); 7.7966 (1.0); 7.7802 (1.1); 7.7764 (1.0); 7.5220 (2.0); 7.5159 (2.0); 7.2654 (12.0); 7.2206 (1.1); 7.2090 (1.0); 7.2004 (1.0); 7.1888 (1.0); 6.9440 (1.7); 6.9379δ = 8.6121 (0.9); 8.6084 (0.9); 8.6005 (0.9); 8.5968 (0.9); 7.8004 (1.0); 7.7966 (1.0); 7.7802 (1.1); 7.7764 (1.0); 7.5220 (2.0); 7.5159 (2.0); 7.2654 (12.0); 7.2206 (1.1); 7.2090 (1.0); 7.2004 (1.0); 7.1888 (1.0); 6.9440 (1.7); 6.9379

(1.7) ; 2.9787 (0.6); 2.4889 (0.6); 1.8973 (16.0); -0.0002 (4.4) (1.7); 2.9787 (0.6); 2.4889 (0.6); 1.8973 (16.0); -0.0002 (4.4)

1.5-170: 1 H-NMR(400.0 MHz, CDCI3):  1.5-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6109 (0.8); 8.6072 (0.8); 8.5993 (0.8); 8.5956 (0.8); 7.8222 (0.7); 7.8184 (0.7); 7.8019 (0.8); 7.7982 (0.8); 7.7292 (1.9); 7.7230 (2.0); 7.2602 (29.0); 7.2407 (0.9); 7.2292 (0.8); 7.2205 (0.8); 7.2089 (0.8); 6.9774 (1.6); 6.9712δ = 8.6109 (0.8); 8.6072 (0.8); 8.5993 (0.8); 8.5956 (0.8); 7.8222 (0.7); 7.8184 (0.7); 7.8019 (0.8); 7.7982 (0.8); 7.7292 (1.9); 7.7230 (2.0); 7.2602 (29.0); 7.2407 (0.9); 7.2292 (0.8); 7.2205 (0.8); 7.2089 (0.8); 6.9774 (1.6); 6.9712

(1.6); 3.9608 (2.7); 3.9468 (2.7); 3.6895 (9.8); 1.9504 (16.0); -0.0002 (11.0) (1.6); 3.9608 (2.7); 3.9468 (2.7); 3.6895 (9.8); 1.9504 (16.0); -0.0002 (11.0)

1.5-171 : 1 H-NMR(400.0 MHz, CDCI3):  1.5-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6141 (1.2); 8.6104 (1.3); 8.6025 (1.4); 8.5988 (1.3); 8.1181 (0.8); 7.7990 (1.7); 7.7952 (1.6); 7.7788 (1.7); 7.7750 (1.7); 7.6978 (0.6); 7.6914 (0.9); 7.6866 (0.9); 7.5197 (0.5); 7.2608 (88.0); 7.2175 (1.7); 7.2059 (1.7); 7.1973 (1.6); 7.1857 (1.5); 6.9968 (0.5); 6.9735 (1.0); 6.9682 (1.1); 6.9323 (0.5); 4.1066 (2.6); 4.0717 (2.5); 3.9885 (1.4); 3.7821 (3.0); 3.7601 (4.2); 3.7542 (6.4); 3.0407 (4.3); 2.9967 (0.7); 2.9333 (2.1); 2.5637 (4.0); 1.9193 (11.4); 1.9141 (7.6); 1.8954 (0.8); 1.5564 (16.0); 1.2553 (0.9); 1.0655 (0.7); 1.0473 (1.4); 1.0291 (0.7); 0.0079 (1.0); -0.0002 (30.9);δ = 8.6141 (1.2); 8.6104 (1.3); 8.6025 (1.4); 8.5988 (1.3); 8.1181 (0.8); 7.7990 (1.7); 7.7952 (1.6); 7.7788 (1.7); 7.7750 (1.7); 7.6978 (0.6); 7.6914 (0.9); 7.6866 (0.9); 7.5197 (0.5); 7.2608 (88.0); 7.2175 (1.7); 7.2059 (1.7); 7.1973 (1.6); 7.1857 (1.5); 6.9968 (0.5); 6.9735 (1.0); 6.9682 (1.1); 6.9323 (0.5); 4.1066 (2.6); 4.0717 (2.5); 3.9885 (1.4); 3.7821 (3.0); 3.7601 (4.2); 3.7542 (6.4); 3.0407 (4.3); 2.9967 (0.7); 2.9333 (2.1); 2.5637 (4.0); 1.9193 (11.4); 1.9141 (7.6); 1.8954 (0.8); 1.5564 (16.0); 1.2553 (0.9); 1.0655 (0.7); 1.0473 (1.4); 1.0291 (0.7); 0.0079 (1.0); -0.0002 (30.9);

-0.0085 (1.0) -0.0085 (1.0)

1.5-193: 1 H-NMR(400.0 MHz, CDCI3):  1.5-193: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6005 (1.0); 8.5890 (1.0); 7.8272 (0.9); 7.8069 (1.0); 7.7016 (1.6); 7.6956 (1.7); 7.2604 (14.1); 7.2504 (1.4); 7.2387 (1.0); 7.2300 (0.9); 7.2184 (0.8); 6.9489 (1.5); 6.9429 (1.6); 5.7837 (0.7); 3.5756 (0.7); 3.5646 (0.8); 3.5605δ = 8.6005 (1.0); 8.5890 (1.0); 7.8272 (0.9); 7.8069 (1.0); 7.7016 (1.6); 7.6956 (1.7); 7.2604 (14.1); 7.2504 (1.4); 7.2387 (1.0); 7.2300 (0.9); 7.2184 (0.8); 6.9489 (1.5); 6.9429 (1.6); 5.7837 (0.7); 3.5756 (0.7); 3.5646 (0.8); 3.5605

(0.9); 3.5496 (0.8); 1.9262 (16.0); 1.5810 (2.0); -0.0002 (4.9) (0.9); 3.5496 (0.8); 1.9262 (16.0); 1.5810 (2.0); -0.0002 (4.9)

1.5-194: 1 H-NMR(400.0 MHz, CDCI3):  1.5-194: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5983 (0.8); 8.5948 (1.0); 8.5868 (0.9); 8.5833 (1.0); 7.7992 (0.8); 7.7956 (1.0); 7.7789 (0.9); 7.7753 (1.0); 7.5400 (1.4); 7.5343 (1.4); 7.2604 (17.9); 7.2203 (0.9); 7.2088 (0.9); 7.2001 (0.8); 7.1886 (0.8); 6.9554 (1.4); 6.9495δ = 8.5983 (0.8); 8,55948 (1.0); 8.5868 (0.9); 8.5833 (1.0); 7.7992 (0.8); 7.7956 (1.0); 7.7789 (0.9); 7.7753 (1.0); 7.5400 (1.4); 7.5343 (1.4); 7.2604 (17.9); 7.2203 (0.9); 7.2088 (0.9); 7.2001 (0.8); 7.1886 (0.8); 6.9554 (1.4); 6.9495

(1.5) ; 2.5767 (1.1); 1.8998 (16.0); 1.5600 (2.2); -0.0002 (6.3) (1.5); 2.5767 (1.1); 1.8998 (16.0); 1.5600 (2.2); -0.0002 (6.3)

1.5-213: 1 H-NMR(400.0 MHz, CDCI3):  1.5-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6109 (0.9); 8.6072 (0.9); 8.5994 (0.9); 8.5957 (0.9); 7.8466 (1.0); 7.8429 (1.0); 7.8264 (1.0); 7.8226 (1.0); 7.7038 (1.9); 7.6976 (2.0); 7.2705 (1.1); 7.2620 (9.2); 7.2591 (1.5); 7.2502 (1.0); 7.2386 (1.0); 6.9549 (1.8); 6.9486δ = 8.6109 (0.9); 8.6072 (0.9); 8.5994 (0.9); 8.5957 (0.9); 7.8466 (1.0); 7.8429 (1.0); 7.8264 (1.0); 7.8226 (1.0); 7.7038 (1.9); 7.6976 (2.0); 7.2705 (1.1); 7.2620 (9.2); 7.2591 (1.5); 7.2502 (1.0); 7.2386 (1.0); 6.9549 (1.8); 6.9486

(1.8) ; 4.1255 (3.3); 4.1113 (3.3); 1.9265 (16.0); -0.0002 (3.1) (1.8); 4.1255 (3.3); 4.1113 (3.3); 1.9265 (16.0); -0.0002 (3.1)

1.5-214: 1 H-NMR(400.0 MHz, CDCI3):  1.5-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6014 (0.8); 8.5977 (0.8); 8.5899 (0.8); 8.5862 (0.8); 7.8053 (0.8); 7.8016 (0.9); 7.7851 (0.9); 7.7813 (0.9); 7.5593 (1.5); 7.5532 (1.6); 7.2623 (8.9); 7.2316 (0.9); 7.2200 (0.9); 7.2114 (0.8); 7.1998 (0.8); 6.9679 (1.4); 6.9618δ = 8.6014 (0.8); 8,597 (0.8); 8,589 (0.8); 8.5862 (0.8); 7.8053 (0.8); 7.8016 (0.9); 7.7851 (0.9); 7.7813 (0.9); 7.5593 (1.5); 7.5532 (1.6); 7.2623 (8.9); 7.2316 (0.9); 7.2200 (0.9); 7.2114 (0.8); 7.1998 (0.8); 6.9679 (1.4); 6.9618

(1.4); 5.2988 (0.7); 1.9134 (16.0); -0.0002 (3.1) (1.4); 5.2988 (0.7); 1.9134 (16.0); -0.0002 (3.1)

1.5-216: 1 H-NMR(400.0 MHz, CDCI3):  1.5-216: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5992 (0.8); 8.5955 (0.8); 8.5877 (0.8); 8.5840 (0.8); 7.8233 (0.8); 7.8196 (0.8); 7.8031 (0.9); 7.7993 (0.9); 7.7044 (1.7); 7.6982 (1.7); 7.2628 (6.6); 7.2549 (0.9); 7.2434 (0.9); 7.2346 (0.8); 7.2231 (0.8); 6.9815 (1.6); 6.9753δ = 8.5992 (0.8); 8.5955 (0.8); 8,587 (0.8); 8.5840 (0.8); 7.8233 (0.8); 7.8196 (0.8); 7.8031 (0.9); 7.7993 (0.9); 7.7044 (1.7); 7.6982 (1.7); 7.2628 (6.6); 7.2549 (0.9); 7.2434 (0.9); 7.2346 (0.8); 7.2231 (0.8); 6.9815 (1.6); 6.9753

(1.6) ; 1.9193 (14.4); 1.6310 (16.0); 1.6182 (0.7); -0.0002 (2.3) (1.6); 1.9193 (14.4); 1.6310 (16.0); 1.6182 (0.7); -0.0002 (2.3)

I.5-227: 1 H-NMR(400.0 MHz, CDCI3):  I.5-227: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6073 (0.8); 8.6036 (0.9); 8.5958 (0.9); 8.5921 (0.9); 7.8339 (0.9); 7.8302 (0.9); 7.8137 (1.0); 7.8099 (1.0); 7.7084 (1.8); 7.7022 (1.9); 7.2624 (8.4); 7.2532 (1.0); 7.2417 (1.0); 7.2329 (0.9); 7.2214 (0.9); 6.9595 (1.7); 6.9533δ = 8.6073 (0.8); 8.6036 (0.9); 8.5958 (0.9); 8.5921 (0.9); 7.8339 (0.9); 7.8302 (0.9); 7.8137 (1.0); 7.8099 (1.0); 7.7084 (1.8); 7.7022 (1.9); 7.2624 (8.4); 7.2532 (1.0); 7.2417 (1.0); 7.2329 (0.9); 7.2214 (0.9); 6.9595 (1.7); 6.9533

(1.7) ; 3.4700 (0.7); 3.4535 (1.8); 3.4378 (1.8); 3.4214 (0.7); 2.5914 (1.5); 2.5747 (3.1); 2.5580 (1.4); 1.9248 (16.0); -(1.7); 3.4700 (0.7); 3.4535 (1.8); 3.4378 (1.8); 3.4214 (0.7); 2.5914 (1.5); 2.5747 (3.1); 2.5580 (1.4); 1.9248 (16.0); -

0.0002 (3.0) 0.0002 (3.0)

I.5-228: 1 H-NMR(400.0 MHz, CDCI3):  I.5-228: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5976 (0.9); 8.5940 (0.9); 8.5861 (0.9); 8.5824 (0.9); 7.7986 (0.9); 7.7949 (0.9); 7.7783 (1.0); 7.7746 (1.0); 7.5814 (1.6); 7.5753 (1.6); 7.2623 (12.7); 7.2217 (1.0); 7.2102 (0.9); 7.2015 (0.9); 7.1899 (0.9); 6.9617 (1.2); 6.9557 (1.2); 5.2987 (7.7); 2.9548 (0.6); 2.8830 (0.6); 2.5941 (0.7); 2.0432 (1.1); 1.9212 (0.6); 1.8979 (16.0); 1.5960 (0.6);δ = 8.5976 (0.9); 8.5940 (0.9); 8.5861 (0.9); 8.5824 (0.9); 7.7986 (0.9); 7.7949 (0.9); 7.7783 (1.0); 7.7746 (1.0); 7.5814 (1.6); 7.5753 (1.6); 7.2623 (12.7); 7.2217 (1.0); 7.2102 (0.9); 7.2015 (0.9); 7.1899 (0.9); 6.9617 (1.2); 6.9557 (1.2); 5.2987 (7.7); 2.9548 (0.6); 2.8830 (0.6); 2.5941 (0.7); 2.0432 (1.1); 1.9212 (0.6); 1.8979 (16.0); 1.5960 (0.6);

1.2582 (0.9); -0.0002 (4.4) 1.2582 (0.9); -0.0002 (4.4)

I.5-248: 1 H-NMR(400.0 MHz, CDCI3):  I.5-248: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6076 (1.0); 8.6039 (1.0); 8.5961 (1.0); 8.5924 (1.0); 7.8893 (1.0); 7.8856 (1.0); 7.8690 (1.0); 7.8653 (1.0); 7.7390 (2.0); 7.7327 (2.1); 7.3883 (1.4); 7.3861 (1.4); 7.2780 (1.2); 7.2664 (1.5); 7.2599 (37.2); 7.2463 (1.1); 6.9670δ = 8.6076 (1.0); 8.6039 (1.0); 8.5961 (1.0); 8.5924 (1.0); 7.8893 (1.0); 7.8856 (1.0); 7.8690 (1.0); 7.8653 (1.0); 7.7390 (2.0); 7.7327 (2.1); 7.3883 (1.4); 7.3861 (1.4); 7.2780 (1.2); 7.2664 (1.5); 7.2599 (37.2); 7.2463 (1.1); 6.9670

(1.8) ; 6.9607 (1.8); 2.0102 (16.0); 1.5922 (1.2); -0.0002 (14.2); -0.0084 (0.6) (1.8); 6.9607 (1.8); 2.0102 (16.0); 1.5922 (1.2); -0.0002 (14.2); -0.0084 (0.6)

I.5-248: 1 H-NMR(400.0 MHz, CDCI3):  I.5-248: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6053 (0.9); 8.6017 (1.0); 8.5938 (1.0); 8.5901 (0.9); 7.8861 (0.9); 7.8824 (1.0); 7.8658 (1.0); 7.8622 (1.0); 7.7381 (1.8); 7.7319 (1.9); 7.3867 (1.6); 7.2745 (1.2); 7.2595 (43.7); 7.2428 (1.0); 6.9630 (1.7); 6.9568 (1.7); 2.0089δ = 8.6053 (0.9); 8.6017 (1.0); 8.5938 (1.0); 8.5901 (0.9); 7.8861 (0.9); 7.8824 (1.0); 7.8658 (1.0); 7.8622 (1.0); 7.7381 (1.8); 7.7319 (1.9); 7.3867 (1.6); 7.2745 (1.2); 7.2595 (43.7); 7.2428 (1.0); 6.9630 (1.7); 6.9568 (1.7); 2.0089

(16.0); 1.5588 (7.1); 0.0070 (1.0); -0.0002 (21.8); -0.0083 (0.9) (16.0); 1.5588 (7.1); 0.0070 (1.0); -0.0002 (21.8); -0.0083 (0.9)

I.5-284: 1 H-NMR(400.0 MHz, CDCI3):  I.5-284: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6109 (1.2); 8.6071 (1.2); 8.5993 (1.2); 8.5955 (1.2); 7.8030 (1.2); 7.7992 (1.2); 7.7828 (1.3); 7.7790 (1.2); 7.5324 (2.6); 7.5263 (2.7); 7.2603 (53.9); 7.2244 (1.3); 7.2128 (1.3); 7.2042 (1.2); 7.1926 (1.2); 6.9540 (2.2); 6.9480δ = 8.6109 (1.2); 8.6071 (1.2); 8.5993 (1.2); 8.5955 (1.2); 7.8030 (1.2); 7.7992 (1.2); 7.7828 (1.3); 7.7790 (1.2); 7.5324 (2.6); 7.5263 (2.7); 7.2603 (53.9); 7.2244 (1.3); 7.2128 (1.3); 7.2042 (1.2); 7.1926 (1.2); 6.9540 (2.2); 6.9480

(2.2) ; 1.8967 (16.0); 1.5564 (3.2); 0.0079 (0.7); -0.0002 (20.9); -0.0085 (0.8) (2.2); 1.8967 (16.0); 1.5564 (3.2); 0.0079 (0.7); -0.0002 (20.9); -0.0085 (0.8)

I.5-284: 1 H-NMR(400.0 MHz, CDCI3):  I.5-284: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6094 (1.2); 8.6056 (1.2); 8.5978 (1.2); 8.5940 (1.2); 7.8004 (1.3); 7.7966 (1.3); 7.7801 (1.4); 7.7763 (1.3); 7.5313 (2.6); 7.5253 (2.6); 7.2606 (25.8); 7.2218 (1.4); 7.2102 (1.4); 7.2016 (1.3); 7.1900 (1.3); 6.9514 (2.3); 6.9454δ = 8.6094 (1.2); 8.6056 (1.2); 8.5978 (1.2); 8.5940 (1.2); 7.8004 (1.3); 7.7966 (1.3); 7.7801 (1.4); 7.7763 (1.3); 7.5313 (2.6); 7.5253 (2.6); 7.2606 (25.8); 7.2218 (1.4); 7.2102 (1.4); 7.2016 (1.3); 7.1900 (1.3); 6.9514 (2.3); 6.9454

(2.3) ; 5.2982 (4.6); 1.8963 (16.0); 1.5594 (2.3); -0.0002 (15.1); -0.0085 (0.6) 1.5-303: 1 H-NMR(400.0 MHz, CDCI3): (2.3); 5.2982 (4.6); 1.8963 (16.0); 1.5594 (2.3); -0.0002 (15.1); -0.0085 (0.6) 1.5-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5897 (0.8); 8.5860 (0.8); 8.5782 (0.8); 8.5744 (0.8); 7.7797 (0.8); 7.7759 (0.9); 7.7595 (0.9); 7.7557 (0.9); 7.6180 (1.7); 7.6119 (1.8); 7.2618 (10.7); 7.1955 (0.9); 7.1839 (0.9); 7.1753 (0.8); 7.1637 (0.8); 6.8947 (1.6); 6.8886δ = 8.5897 (0.8); 8,55860 (0.8); 8.5782 (0.8); 8.5744 (0.8); 7.7797 (0.8); 7.7759 (0.9); 7.7595 (0.9); 7.7557 (0.9); 7.6180 (1.7); 7.6119 (1.8); 7.2618 (10.7); 7.1955 (0.9); 7.1839 (0.9); 7.1753 (0.8); 7.1637 (0.8); 6.8947 (1.6); 6.8886

(1.6); 3.1579 (7.2); 2.9892 (4.2); 1.8915 (16.0); -0.0002 (3.9) (1.6); 3.1579 (7.2); 2.9892 (4.2); 1.8915 (16.0); -0.0002 (3.9)

I.5-353: 1 H-NMR(400.0 MHz, CDCI3):  I.5-353: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5942 (0.9); 8.5905 (0.9); 8.5826 (1.0); 8.5789 (0.9); 7.8516 (1.0); 7.8479 (1.0); 7.8313 (1.1); 7.8276 (1.1); 7.6984 (2.0); 7.6922 (2.1); 7.2823 (1.1); 7.2707 (1.2); 7.2624 (27.6); 7.2504 (1.1); 6.9413 (1.9); 6.9350 (1.9); 3.9290 (1.2); 3.9208 (0.8); 3.9181 (1.3); 3.9143 (0.8); 3.9112 (0.6); 3.9068 (1.5); 3.8366 (0.7); 3.8176 (0.7); 3.7400 (1.5);δ = 8.5942 (0.9); 8.5905 (0.9); 8.5826 (1.0); 8.5789 (0.9); 7.8516 (1.0); 7.8479 (1.0); 7.8313 (1.1); 7.8276 (1.1); 7.6984 (2.0); 7.6922 (2.1); 7.2823 (1.1); 7.2707 (1.2); 7.2624 (27.6); 7.2504 (1.1); 6.9413 (1.9); 6.9350 (1.9); 3.9290 (1.2); 3.9208 (0.8); 3.9181 (1.3); 3.9143 (0.8); 3.9112 (0.6); 3.9068 (1.5); 3.8366 (0.7); 3.8176 (0.7); 3.7400 (1.5);

3.6964 (1.0); 3.6850 (1.1); 3.6742 (0.9); 1.9383 (16.0); -0.0002 (9.6) 3.6964 (1.0); 3.6850 (1.1); 3.6742 (0.9); 1.9383 (16.0); -0.0002 (9.6)

I.5-374: 1 H-NMR(400.0 MHz, CDCI3):  I.5-374: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5924 (2.4); 8.5887 (2.6); 8.5810 (2.6); 8.5772 (2.7); 8.0928 (1.2); 7.8236 (2.5); 7.8198 (2.6); 7.8033 (2.8); 7.7995 (2.8); 7.7061 (5.4); 7.6998 (5.6); 7.2619 (49.9); 7.2565 (4.1); 7.2450 (3.2); 7.2362 (2.9); 7.2247 (2.8); 7.0071δ = 8.5924 (2.4); 8.5887 (2.6); 8.5810 (2.6); 8.5772 (2.7); 8.0928 (1.2); 7.8236 (2.5); 7.8198 (2.6); 7.8033 (2.8); 7.7995 (2.8); 7.7061 (5.4); 7.6998 (5.6); 7.2619 (49.9); 7.2565 (4.1); 7.2450 (3.2); 7.2362 (2.9); 7.2247 (2.8); 7.0071

(5.0) ; 7.0008 (5.1); 5.2990 (3.1); 3.4209 (2.6); 3.3916 (3.3); 3.2850 (2.5); 3.2570 (3.0); 3.1838 (2.2); 3.1812 (2.3); 3.1545 (1.8); 3.1519 (1.8); 3.0915 (1.6); 3.0805 (2.0); 3.0751 (2.0); 3.0714 (2.0); 3.0674 (2.3); 3.0620 (2.1); 3.0550(5.0); 7,0008 (5.1); 5.2990 (3.1); 3.4209 (2.6); 3.3916 (3.3); 3.2850 (2.5); 3.2570 (3.0); 3.1838 (2.2); 3.1812 (2.3); 3.1545 (1.8); 3.1519 (1.8); 3.0915 (1.6); 3.0805 (2.0); 3.0751 (2.0); 3.0714 (2.0); 3.0674 (2.3); 3.0620 (2.1); 3.0550

(2.1) ; 3.0489 (2.2); 3.0253 (0.8); 3.0137 (0.9); 3.0060 (0.9); 2.9979 (1.2); 2.9944 (1.0); 2.9863 (1.2); 2.9786 (1.2); 2.9670 (1.3); 2.9617 (2.7); 2.9592 (2.7); 2.9337 (2.2); 2.9312 (2.2); 2.8677 (0.9); 2.8507 (1.1); 2.8469 (1.1); 2.8404 (0.7); 2.8299 (1.1); 2.8234 (0.8); 2.8196 (0.9); 2.8026 (0.8); 2.6252 (0.5); 2.6224 (0.5); 2.6200 (0.5); 2.6044 (0.9); 2.6015 (0.7); 2.5925 (0.7); 2.5896 (0.8); 2.5873 (0.7); 2.5845 (0.7); 2.5756 (0.6); 2.5728 (0.6); 2.4507 (0.9); 2.4309(2.1); 3.0489 (2.2); 3.0253 (0.8); 3.0137 (0.9); 3.0060 (0.9); 2.9979 (1.2); 2.9944 (1.0); 2.9863 (1.2); 2.9786 (1.2); 2.9670 (1.3); 2.9617 (2.7); 2.9592 (2.7); 2.9337 (2.2); 2.9312 (2.2); 2.8677 (0.9); 2.8507 (1.1); 2.8469 (1.1); 2.8404 (0.7); 2.8299 (1.1); 2.8234 (0.8); 2.8196 (0.9); 2.8026 (0.8); 2.6252 (0.5); 2.6224 (0.5); 2.6200 (0.5); 2.6044 (0.9); 2.6015 (0.7); 2.5925 (0.7); 2.5896 (0.8); 2.5873 (0.7); 2.5845 (0.7); 2.5756 (0.6); 2.5728 (0.6); 2.4507 (0.9); 2.4309

(1.5) ; 2.4181 (0.7); 2.4106 (0.8); 2.3981 (1.2); 2.3933 (0.7); 2.3778 (0.7); 2.3735 (1.0); 2.3611 (1.0); 2.3600 (1.1); 2.3547 (0.6); 2.3413 (1.9); 2.3225 (1.0); 2.3214 (1.0); 2.2981 (0.9); 2.2955 (0.9); 2.2849 (1.0); 2.2821 (1.5); 2.2792 (0.9); 2.2685 (0.9); 2.2660 (1.2); 2.2634 (0.6); 2.2528 (0.5); 2.2500 (0.7); 1.9374 (15.7); 1.9317 (16.0); 1.9035 (0.8); 1.8848 (0.9); 1.5899 (0.5); 0.0080 (0.6); -0.0002 (17.8); -0.0085 (0.6) (1.5); 2.4181 (0.7); 2.4106 (0.8); 2.3981 (1.2); 2.3933 (0.7); 2.3778 (0.7); 2.3735 (1.0); 2.3611 (1.0); 2.3600 (1.1); 2.3547 (0.6); 2.3413 (1.9); 2.3225 (1.0); 2.3214 (1.0); 2.2981 (0.9); 2.2955 (0.9); 2.2849 (1.0); 2.2821 (1.5); 2.2792 (0.9); 2.2685 (0.9); 2.2660 (1.2); 2.2634 (0.6); 2.2528 (0.5); 2.2500 (0.7); 1.9374 (15.7); 1.9317 (16.0); 1.9035 (0.8); 1.8848 (0.9); 1.5899 (0.5); 0.0080 (0.6); -0.0002 (17.8); -0.0085 (0.6)

1.5- 375: 1 H-NMR(400.0 MHz, CDCI3):  1.5-375: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5980 (1.1); 8.5958 (1.1); 8.5866 (1.2); 8.5844 (1.2); 7.8172 (1.0); 7.8150 (1.0); 7.7969 (1.2); 7.7947 (1.2); 7.6918 (1.9); 7.6859 (2.0); 7.2634 (7.1); 7.2409 (1.1); 7.2293 (1.1); 7.2206 (1.0); 7.2090 (1.0); 7.0136 (0.7); 6.9576 (1.8); 6.9518 (1.9); 3.8409 (1.0); 3.8339 (1.5); 3.8283 (1.2); 3.8181 (1.2); 3.8112 (2.0); 3.7984 (1.6); 3.7790 (1.0); 3.6504 (1.9); 3.6279 (1.6); 2.1327 (0.8); 2.1194 (0.6); 2.1143 (0.6); 1.8947 (16.0); 1.8732 (1.6); 1.8607 (0.9); 1.8536 (0.8); 1.8413 (0.9); 1.4245 (9.6); 1.2572 (0.6); -0.0002 (2.5) δ = 8.5980 (1.1); 8.5958 (1.1); 8.5866 (1.2); 8.5844 (1.2); 7.8172 (1.0); 7.8150 (1.0); 7.7969 (1.2); 7.7947 (1.2); 7.6918 (1.9); 7.6859 (2.0); 7.2634 (7.1); 7.2409 (1.1); 7.2293 (1.1); 7.2206 (1.0); 7.2090 (1.0); 7.0136 (0.7); 6.9576 (1.8); 6.9518 (1.9); 3.8409 (1.0); 3.8339 (1.5); 3.8283 (1.2); 3.8181 (1.2); 3.8112 (2.0); 3.7984 (1.6); 3.7790 (1.0); 3.6504 (1.9); 3.6279 (1.6); 2.1327 (0.8); 2.1194 (0.6); 2.1143 (0.6); 1.8947 (16.0); 1.8732 (1.6); 1.8607 (0.9); 1.8536 (0.8); 1.8413 (0.9); 1.4245 (9.6); 1.2572 (0.6); -0.0002 (2.5)

1.6- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.6- 1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6331 (0.9); 8.6294 (0.9); 8.6216 (0.9); 8.6179 (0.9); 8.0207 (1.0); 8.0170 (1.0); 8.0005 (1.0); 7.9967 (1.0); 7.6737 (1.9); 7.6675 (2.0); 7.2633 (8.0); 7.1621 (1.0); 7.1506 (1.0); 7.1419 (1.0); 7.1304 (1.0); 6.8806 (1.8); 6.8744 (1.8); 5.2986 (1.3); 2.6618 (0.6); 2.6534 (0.6); 1.8935 (16.0); 1.6245 (0.5); 0.7099 (0.9); 0.7064 (1.3); 0.7037 (0.7); 0.6923 (1.2); 0.6885 (1.0); 0.6857 (0.6); 0.4097 (0.8); 0.4068 (1.0); 0.4032 (0.9); 0.4008 (0.8); 0.3971 (1.0); 0.3936δ = 8.6331 (0.9); 8.6294 (0.9); 8.6216 (0.9); 8.6179 (0.9); 8.0207 (1.0); 8.0170 (1.0); 8,0005 (1.0); 7.9967 (1.0); 7.6737 (1.9); 7.6675 (2.0); 7.2633 (8.0); 7.1621 (1.0); 7.1506 (1.0); 7.1419 (1.0); 7.1304 (1.0); 6.8806 (1.8); 6.8744 (1.8); 5.2986 (1.3); 2.6618 (0.6); 2.6534 (0.6); 1.8935 (16.0); 1.6245 (0.5); 0.7099 (0.9); 0.7064 (1.3); 0.7037 (0.7); 0.6923 (1.2); 0.6885 (1.0); 0.6857 (0.6); 0.4097 (0.8); 0.4068 (1.0); 0.4032 (0.9); 0.4008 (0.8); 0.3971 (1.0); 0.3936

(0.9); -0.0002 (3.0) (0.9); -0.0002 (3.0)

1.6-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.6-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6267 (0.8); 8.6231 (0.8); 8.6152 (0.8); 8.6116 (0.8); 7.9942 (0.8); 7.9905 (0.8); 7.9740 (0.9); 7.9704 (0.9); 7.5599 (1.7); 7.5539 (1.7); 7.2638 (7.0); 7.1295 (0.9); 7.1179 (0.8); 7.1093 (0.8); 7.0977 (0.8); 6.8749 (1.6); 6.8689δ = 8.6267 (0.8); 8.6231 (0.8); 8.6152 (0.8); 8.6116 (0.8); 7.9942 (0.8); 7.9905 (0.8); 7.9740 (0.9); 7.9704 (0.9); 7.5599 (1.7); 7.5539 (1.7); 7.2638 (7.0); 7.1295 (0.9); 7.1179 (0.8); 7.1093 (0.8); 7.0977 (0.8); 6.8749 (1.6); 6.8689

(1.6) ; 3.5350 (1.1); 2.6331 (1.1); 1.8829 (16.0); 1.7187 (1.0); 1.7091 (1.3); 1.7016 (2.9); 1.6938 (1.2); 1.6846 (1.0); -(1.6); 3.5350 (1.1); 2.6331 (1.1); 1.8829 (16.0); 1.7187 (1.0); 1.7091 (1.3); 1.7016 (2.9); 1.6938 (1.2); 1.6846 (1.0); -

0.0002 (2.6) 0.0002 (2.6)

1.6-167: 1 H-NMR(400.0 MHz, CDCI3):  1.6-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6308 (0.8); 8.6272 (0.8); 8.6193 (0.8); 8.6156 (0.8); 7.9958 (0.8); 7.9920 (0.8); 7.9756 (0.8); 7.9719 (0.8); 7.5150 (1.6); 7.5090 (1.7); 7.2614 (12.9); 7.1298 (0.8); 7.1182 (0.8); 7.1096 (0.8); 7.0980 (0.8); 6.8969 (1.5); 6.8908 (1.5); 5.2986 (0.6); 1.8900 (16.0); 1.5754 (0.9); -0.0002 (4.8) δ = 8.6308 (0.8); 8.6272 (0.8); 8.6193 (0.8); 8.6156 (0.8); 7.9958 (0.8); 7.9920 (0.8); 7.9756 (0.8); 7.9719 (0.8); 7.5150 (1.6); 7.5090 (1.7); 7.2614 (12.9); 7.1298 (0.8); 7.1182 (0.8); 7.1096 (0.8); 7.0980 (0.8); 6.8969 (1.5); 6.8908 (1.5); 5.2986 (0.6); 1.8900 (16.0); 1.5754 (0.9); -0.0002 (4.8)

1.6- 213: 1 H-NMR(400.0 MHz, CDCI3):  1.6-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6432 (0.8); 8.6396 (0.9); 8.6318 (0.8); 8.6281 (0.9); 8.0421 (0.9); 8.0384 (0.9); 8.0219 (0.9); 8.0182 (1.0); 7.7039 (1.8); 7.6977 (1.8); 7.2622 (8.3); 7.1880 (0.9); 7.1765 (0.9); 7.1677 (0.9); 7.1562 (0.9); 6.9206 (1.7); 6.9144δ = 8.6432 (0.8); 8.6396 (0.9); 8.6318 (0.8); 8.6281 (0.9); 8.0421 (0.9); 8.0384 (0.9); 8.0219 (0.9); 8.0182 (1.0); 7.7039 (1.8); 7.6977 (1.8); 7.2622 (8.3); 7.1880 (0.9); 7.1765 (0.9); 7.1677 (0.9); 7.1562 (0.9); 6.9206 (1.7); 6.9144

(1.7) ; 5.2986 (0.9); 4.1299 (3.6); 4.1157 (3.3); 2.0430 (1.6); 1.9237 (16.0); 1.2580 (1.4); -0.0002 (3.1) (1.7); 5.2986 (0.9); 4.1299 (3.6); 4.1157 (3.3); 2.0430 (1.6); 1.9237 (16.0); 1.2580 (1.4); -0.0002 (3.1)

1.7- 1 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.7-1: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.4433 (0.8); 8.4405 (0.8); 8.4316 (0.8); 8.4288 (0.8); 7.8546 (2.7); 7.8485 (2.8); 7.6667 (0.8); 7.6644 (0.8); 7.6625 (0.7); 7.6494 (0.7); 7.6476 (0.8); 7.6452 (0.8); 7.6435 (0.7); 7.4468 (0.5); 7.2322 (1.0); 7.2205 (1.0); 7.2132 (0.9); 7.2014 (0.9); 6.7993 (2.9); 6.7932 (2.9); 5.7538 (1.3); 3.3121 (14.8); 2.6243 (0.5); 2.6157 (0.9); 2.6061 (0.9); 2.5975 (0.5); 2.5595 (7.7); 2.5234 (0.5); 2.5100 (8.2); 2.5055 (16.9); 2.5009 (23.3); 2.4964 (16.0); 2.4918 (7.2); 1.7228 (16.0); 1.6956 (0.9); 0.6013 (1.3); 0.5957 (1.7); 0.5834 (1.7); 0.5778 (1.2); 0.5662 (0.6); 0.4184 (0.6); 0.4072δ = 8.4433 (0.8); 8.4405 (0.8); 8.4316 (0.8); 8.4288 (0.8); 7.8546 (2.7); 7.8485 (2.8); 7.6667 (0.8); 7.6644 (0.8); 7.6625 (0.7); 7.6494 (0.7); 7.6476 (0.8); 7.6452 (0.8); 7.6435 (0.7); 7.4468 (0.5); 7.2322 (1.0); 7.2205 (1.0); 7.2132 (0.9); 7.2014 (0.9); 6.7993 (2.9); 6.7932 (2.9); 5.7538 (1.3); 3.3121 (14.8); 2.6243 (0.5); 2.6157 (0.9); 2.6061 (0.9); 2.5975 (0.5); 2.5595 (7.7); 2.5234 (0.5); 2.5100 (8.2); 2.5055 (16.9); 2.5009 (23.3); 2.4964 (16.0); 2.4918 (7.2); 1.7228 (16.0); 1.6956 (0.9); 0.6013 (1.3); 0.5957 (1.7); 0.5834 (1.7); 0.5778 (1.2); 0.5662 (0.6); 0.4184 (0.6); 0.4072

(1.5); 0.4015 (1.4); 0.3972 (1.3); 0.3917 (1.3); -0.0002 (6.5) (1.5); 0.4015 (1.4); 0.3972 (1.3); 0.3917 (1.3); -0.0002 (6.5)

I.7-3: 1 H-NMR(400.0 MHz, CDCI3):  I.7-3: 1H-NMR (400.0 MHz, CDCl3):

δ= 8.5325 (0.5); 8.5297 (0.6); 8.5208 (0.6); 8.5178 (0.5); 7.6585 (1.9); 7.6523 (2.0); 7.6102 (0.5); 7.6081 (0.5); 7.5910 (0.6); 7.5888 (0.6); 7.2608 (20.8); 7.2050 (0.7); 7.1932 (0.7); 7.1859 (0.7); 7.1740 (0.6); 6.9472 (1.9); 6.9410δ = 8.5325 (0.5); 8.5297 (0.6); 8.5208 (0.6); 8.5178 (0.5); 7.6585 (1.9); 7.6523 (2.0); 7.6102 (0.5); 7.6081 (0.5); 7.5910 (0.6); 7.5888 (0.6); 7.2608 (20.8); 7.2050 (0.7); 7.1932 (0.7); 7.1859 (0.7); 7.1740 (0.6); 6.9472 (1.9); 6.9410

(1.8) ; 2.6229 (6.0); 1.8916 (16.0); 1.8693 (0.8); 1.5028 (0.7); 1.4876 (1.6); 1.4819 (1.6); 1.4793 (0.9); 1.4674 (0.8);(1.8); 2.6229 (6.0); 1.8916 (16.0); 1.8693 (0.8); 1.5028 (0.7); 1.4876 (1.6); 1.4819 (1.6); 1.4793 (0.9); 1.4674 (0.8);

1.1029 (0.8); 1.0912 (0.9); 1.0884 (1.5); 1.0827 (1.5); 1.0675 (0.7); -0.0002 (7.1) 1.1029 (0.8); 1.0912 (0.9); 1.0884 (1.5); 1.0827 (1.5); 1.0675 (0.7); -0.0002 (7.1)

I.7-38: 1 H-NMR(400.0 MHz, CDCI3):  I.7-38: 1H NMR (400.0 MHz, CDCl3):

δ= 8.5185 (0.6); 8.5092 (0.6); 7.6700 (1.9); 7.6638 (2.0); 7.5868 (0.5); 7.5664 (0.5); 7.2599 (53.6); 7.1776 (0.6); 7.1658 (0.6); 7.1583 (0.6); 7.1466 (0.5); 6.9765 (1.6); 6.9704 (1.6); 3.8234 (0.8); 3.8092 (0.8); 3.7999 (1.0); 3.7856 (0.9); 3.7413 (0.5); 3.7232 (1.6); 3.7087 (0.7); 3.7035 (0.9); 3.6883 (0.7); 3.4917 (0.6); 3.4842 (0.6); 3.4681 (0.5); 2.6468 (6.3); 1.8931 (16.0); 1.8645 (0.9); 1.5534 (3.4); 1.2555 (0.6); 0.0079 (0.6); -0.0002 (18.9); -0.0085 (0.6) 1.7-101 : 1 H-NMR(400.0 MHz, CDCI3): δ = 8.5185 (0.6); 8.5092 (0.6); 7.6700 (1.9); 7.6638 (2.0); 7.5868 (0.5); 7.5664 (0.5); 7.2599 (53.6); 7.1776 (0.6); 7.1658 (0.6); 7.1583 (0.6); 7.1466 (0.5); 6.9765 (1.6); 6.9704 (1.6); 3.8234 (0.8); 3.8092 (0.8); 3.7999 (1.0); 3.7856 (0.9); 3.7413 (0.5); 3.7232 (1.6); 3.7087 (0.7); 3.7035 (0.9); 3.6883 (0.7); 3.4917 (0.6); 3.4842 (0.6); 3.4681 (0.5); 2.6468 (6.3); 1.8931 (16.0); 1.8645 (0.9); 1.5534 (3.4); 1.2555 (0.6); 0.0079 (0.6); -0.0002 (18.9); -0.0085 (0.6) 1.7-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.4959 (0.5); 8.4870 (0.5); 8.4842 (0.5); 7.5607 (0.5); 7.5587 (0.5); 7.5490 (1.9); 7.5430 (2.3); 7.2617 (15.3); 7.1418 (0.6); 7.1300 (0.6); 7.1227 (0.6); 7.1109 (0.6); 6.9430 (1.3); 6.9370 (1.3); 3.5373 (0.9); 2.6091 (5.7); 2.5696δ = 8.4959 (0.5); 8.4870 (0.5); 8.4842 (0.5); 7.5607 (0.5); 7.5587 (0.5); 7.5490 (1.9); 7.5430 (2.3); 7.2617 (15.3); 7.1418 (0.6); 7.1300 (0.6); 7.1227 (0.6); 7.1109 (0.6); 6.9430 (1.3); 6.9370 (1.3); 3.5373 (0.9); 2.6091 (5.7); 2.5696

(0.9); 1.8541 (16.0); 1.6891 (1.3); 1.6805 (1.3); 1.6723 (1.2); -0.0002 (5.2) (0.9); 1.8541 (16.0); 1.6891 (1.3); 1.6805 (1.3); 1.6723 (1.2); -0.0002 (5.2)

1.7-213: 1 H-NMR(400.0 MHz, CDCI3):  1.7-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5310 (0.5); 8.5228 (0.5); 8.5201 (0.5); 7.6892 (1.8); 7.6830 (1.8); 7.6131 (0.5); 7.5960 (0.6); 7.5939 (0.6); 7.2599 (35.0); 7.2094 (0.7); 7.1975 (0.8); 7.1901 (0.8); 7.1784 (0.8); 6.9504 (1.7); 6.9442 (1.7); 4.0877 (3.3); 4.0732δ = 8.5310 (0.5); 8.5228 (0.5); 8.5201 (0.5); 7.6892 (1.8); 7.6830 (1.8); 7.6131 (0.5); 7.5960 (0.6); 7.5939 (0.6); 7.2599 (35.0); 7.2094 (0.7); 7.1975 (0.8); 7.1901 (0.8); 7.1.784 (0.8); 6.9504 (1.7); 6.9442 (1.7); 4.0877 (3.3); 4.0732

(3.3); 2.6311 (5.9); 1.9263 (16.0); 1.9002 (0.9); -0.0002 (12.5) (3.3); 2.6311 (5.9); 1.9263 (16.0); 1.9002 (0.9); -0.0002 (12.5)

I.7-284: 1 H-NMR(400.0 MHz, CDCI3):  I.7-284: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.5141 (0.7); 8.5048 (0.7); 7.5870 (0.5); 7.5697 (0.6); 7.5238 (2.4); 7.5178 (2.4); 7.2611 (24.7); 7.1566 (0.5); 6.9971 (0.6); 2.6248 (7.4); 1.8601 (16.0); 1.8379 (0.7); -0.0002 (10.4) δ = 8.5141 (0.7); 8.5048 (0.7); 7,55870 (0.5); 7.5697 (0.6); 7.5238 (2.4); 7.5178 (2.4); 7.2611 (24.7); 7.1566 (0.5); 6.9971 (0.6); 2.6248 (7.4); 1.8601 (16.0); 1.8379 (0.7); -0.0002 (10.4)

1.7- 137: 1 H-NMR(400.0 MHz, CDCI3):  1.7-137: 1 H-NMR (400.0 MHz, CDCl 3):

5= 7.5356 (1.5); 7.5296 (1.6); 7.2605 (23.6); 2.6179 (5.1); 1.8661 (16.0); 1.8495 (0.9); -0.0002 (9.6)  5 = 7.5356 (1.5); 7.5296 (1.6); 7.2605 (23.6); 2.6179 (5.1); 1.8661 (16.0); 1.8495 (0.9); -0.0002 (9.6)

1.8- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.8- 1: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6212 (1.6); 7.6150 (1.7); 7.2597 (24.6); 7.2302 (1.5); 7.2168 (1.6); 6.9715 (1.6); 6.9582 (1.5); 6.8974 (1.6); 6.8913 (1.5); 2.6724 (0.6); 2.6633 (0.6); 1.8537 (16.0); 1.8419 (0.6); 1.5451 (8.8); 0.7246 (1.1); 0.7212 (1.3); 0.7075δ = 7.6212 (1.6); 7.6150 (1.7); 7.2597 (24.6); 7.2302 (1.5); 7.2168 (1.6); 6.9715 (1.6); 6.9582 (1.5); 6.8974 (1.6); 6.8913 (1.5); 2.6724 (0.6); 2.6633 (0.6); 1.8537 (16.0); 1.8419 (0.6); 1.5451 (8.8); 0.7246 (1.1); 0.7212 (1.3); 0.7075

(1.3); 0.7035 (1.0); 0.3910 (0.9); 0.3881 (1.1); 0.3846 (1.1); 0.3784 (1.1); 0.3750 (1.0); -0.0002 (8.8) (1.3); 0.7035 (1.0); 0.3910 (0.9); 0.3881 (1.1); 0.3846 (1.1); 0.3784 (1.1); 0.3750 (1.0); -0.0002 (8.8)

1.8-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.8-101: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5179 (2.4); 7.2704 (19.3); 7.2596 (20.3); 7.1978 (1.2); 7.1859 (2.1); 7.1750 (1.5); 6.9493 (2.5); 6.9380 (4.3); 3.5370 (2.5); 2.5616 (2.6); 1.8432 (14.7); 1.8333 (16.0); 1.7003 (5.5); 1.5578 (6.4); 1.5480 (6.4); 0.0104 (7.6); -δ = 7.5179 (2.4); 7.2704 (19.3); 7.2596 (20.3); 7.1978 (1.2); 7.1859 (2.1); 7.1750 (1.5); 6.9493 (2.5); 6.9380 (4.3); 3.5370 (2.5); 2.5616 (2.6); 1.8432 (14.7); 1.8333 (16.0); 1.7003 (5.5); 1.5578 (6.4); 1.5480 (6.4); 0.0104 (7.6); -

0.0002 (8.1) 0.0002 (8.1)

1.8-152: 1 H-NMR(400.0 MHz, CDCI3):  1.8-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5068 (1.2); 7.5006 (0.8); 7.2659 (30.2); 7.2594 (54.0); 7.2032 (0.7); 7.1898 (0.8); 6.9653 (1.2); 6.9592 (0.8); 6.9478 (0.8); 6.9344 (0.7); 1.8400 (5.2); 1.8340 (7.6); 1.5393 (9.1); 1.5328 (16.0); 0.0063 (11.6); -0.0002 (21.2); -δ = 7.5068 (1.2); 7.5006 (0.8); 7.2659 (30.2); 7.2594 (54.0); 7.2032 (0.7); 7.1898 (0.8); 6.9653 (1.2); 6.9592 (0.8); 6.9478 (0.8); 6.9344 (0.7); 1.8400 (5.2); 1.8340 (7.6); 1.5393 (9.1); 1.5328 (16.0); 0.0063 (11.6); -0.0002 (21.2); -

0.0084 (1.1) 0.0084 (1.1)

I.8-353: 1 H-NMR(400.0 MHz, CDCI3):  I.8-353: 1 H NMR (400.0 MHz, CDCl 3):

δ= 9.4143 (0.6); 7.6459 (2.0); 7.6396 (2.0); 7.2606 (25.2); 7.2517 (2.1); 7.2383 (2.0); 6.9840 (2.0); 6.9706 (1.9); 6.9246 (1.8); 6.9182 (1.8); 3.9557 (0.7); 3.9088 (1.2); 3.9042 (0.5); 3.9006 (0.9); 3.8979 (1.3); 3.8944 (0.8); 3.8906 (0.6); 3.8867 (1.4); 3.6621 (0.7); 3.6512 (0.8); 3.6408 (0.6); 2.0432 (2.0); 1.9059 (16.0); 1.8939 (0.6); 1.5700 (0.8); 1.2762 (0.6); 1.2583 (1.2); 1.2405 (0.6); 1.1087 (0.6); 1.1053 (0.6); 1.0904 (1.2); 1.0869 (1.1); 1.0719 (0.5); 0.8818 (0.5); -0.0002 (9.8) δ = 9.4143 (0.6); 7.6459 (2.0); 7.6396 (2.0); 7.2606 (25.2); 7.2517 (2.1); 7.2383 (2.0); 6.9840 (2.0); 6.9706 (1.9); 6.9246 (1.8); 6.9182 (1.8); 3.9557 (0.7); 3.9088 (1.2); 3.9042 (0.5); 3.9006 (0.9); 3.8979 (1.3); 3.8944 (0.8); 3.8906 (0.6); 3.8867 (1.4); 3.6621 (0.7); 3.6512 (0.8); 3.6408 (0.6); 2.0432 (2.0); 1.9059 (16.0); 1.8939 (0.6); 1.5700 (0.8); 1.2762 (0.6); 1.2583 (1.2); 1.2405 (0.6); 1.1087 (0.6); 1.1053 (0.6); 1.0904 (1.2); 1.0869 (1.1); 1.0719 (0.5); 0.8818 (0.5); -0.0002 (9.8)

1.15- 167: 1 H-NMR(400.0 MHz, CDCI3):  1.15-167: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4506 (1.7); 7.4383 (1.8); 7.3446 (0.7); 7.2609 (11.4); 7.0010 (0.9); 6.9820 (1.1); 6.9799 (1.0); 6.9612 (0.8); 1.8694 (0.7); 1.8294 (16.0); 1.5631 (2.2); -0.0002 (4.4) δ = 7.4506 (1.7); 7.4383 (1.8); 7.3446 (0.7); 7.2609 (11.4); 7.0010 (0.9); 6.9820 (1.1); 6.9799 (1.0); 6.9612 (0.8); 1.8694 (0.7); 1.8294 (16.0); 1.5631 (2.2); -0.0002 (4.4)

1.16- 1 : 1 H-NMR(400.6 MHz, CDCI3):  1.16-1: 1 H-NMR (400.6 MHz, CDCl3):

δ= 7.5628 (1.8); 7.5509 (1.8); 7.2612 (24.0); 7.2545 (0.6); 7.2515 (0.7); 7.2356 (0.8); 7.2326 (0.9); 7.2135 (0.6); 2.6839 (0.5); 2.6749 (0.5); 1.8345 (16.0); 1.5666 (3.0); 0.7377 (0.8); 0.7343 (1.2); 0.7216 (0.8); 0.7201 (1.0); 0.7165δ = 7.5628 (1.8); 7.5509 (1.8); 7.2612 (24.0); 7.2545 (0.6); 7.2515 (0.7); 7.2356 (0.8); 7.2326 (0.9); 7.2135 (0.6); 2.6839 (0.5); 2.6749 (0.5); 1.8345 (16.0); 1.5666 (3.0); 0.7377 (0.8); 0.7343 (1.2); 0.7216 (0.8); 0.7201 (1.0); 0.7165

(0.9); 0.4123 (0.7); 0.4092 (0.8); 0.4058 (0.8); 0.4032 (0.6); 0.3995 (0.8); 0.3962 (0.7); -0.0002 (8.1) (0.9); 0.4123 (0.7); 0.4092 (0.8); 0.4058 (0.8); 0.4032 (0.6); 0.3995 (0.8); 0.3962 (0.7); -0.0002 (8.1)

1.16-2: 1 H-NMR(400.6 MHz, CDCI3):  1.16-2: 1 H NMR (400.6 MHz, CDCl 3):

δ= 7.5465 (1.8); 7.5345 (1.8); 7.2613 (18.7); 7.2565 (0.7); 7.2535 (0.7); 7.2376 (0.8); 7.2345 (0.9); 7.2156 (0.6); 1.8100 (16.0); 1.5696 (3.8); 1.3130 (5.9); 0.6123 (1.2); 0.6081 (0.9); 0.5958 (1.1); 0.5912 (1.6); 0.5887 (1.1); 0.5856δ = 7.5465 (1.8); 7.5345 (1.8); 7.2613 (18.7); 7.2565 (0.7); 7.2535 (0.7); 7.2376 (0.8); 7.2345 (0.9); 7.2156 (0.6); 1.8100 (16.0); 1.5696 (3.8); 1.3130 (5.9); 0.6123 (1.2); 0.6081 (0.9); 0.5958 (1.1); 0.5912 (1.6); 0.5887 (1.1); 0.5856

(1.3); -0.0002 (6.3) (1.3); -0.0002 (6.3)

1.16-101 : 1 H-NMR(400.6 MHz, CDCI3):  1.16-101: 1 H-NMR (400.6 MHz, CDCl 3):

δ= 7.6604 (0.5); 7.6559 (0.6); 7.4548 (1.8); 7.4425 (1.8); 7.2612 (27.6); 7.2251 (0.5); 7.2222 (0.6); 7.2063 (0.8); 7.2033 (0.9); 3.5387 (0.7); 2.6741 (0.8); 1.8255 (0.7); 1.8173 (16.0); 1.7587 (0.5); 1.7485 (0.9); 1.7417 (1.6); 1.7347δ = 7.6604 (0.5); 7.6559 (0.6); 7.4548 (1.8); 7.4425 (1.8); 7.2612 (27.6); 7.2251 (0.5); 7.2222 (0.6); 7.2063 (0.8); 7.2033 (0.9); 3.5387 (0.7); 2.6741 (0.8); 1.8255 (0.7); 1.8173 (16.0); 1.7587 (0.5); 1.7485 (0.9); 1.7417 (1.6); 1.7347

(0.9); 1.5678 (7.0); -0.0002 (9.6) (0.9); 1.5678 (7.0); -0.0002 (9.6)

1.16-152: 1 H-NMR(400.6 MHz, CDCI3):  1.16-152: 1 H-NMR (400.6 MHz, CDCl 3):

δ= 7.6527 (0.5); 7.6482 (0.5); 7.4444 (1.8); 7.4321 (1.8); 7.2610 (37.9); 7.2326 (0.6); 7.2296 (0.6); 7.2137 (0.8);δ = 7.6527 (0.5); 7.6482 (0.5); 7.4444 (1.8); 7.4321 (1.8); 7.2610 (37.9); 7.2326 (0.6); 7.2296 (0.6); 7.2137 (0.8);

7.2107 (0.9); 1.8237 (16.0); 1.5562 (13.2); -0.0002 (13.1) 7.2107 (0.9); 1.8237 (16.0); 1.5562 (13.2); -0.0002 (13.1)

1.16-167: 1 H-NMR(400.6 MHz, CDCI3):  1.16-167: 1 H-NMR (400.6 MHz, CDCl 3):

δ= 7.6638 (0.5); 7.4143 (1.7); 7.4021 (1.7); 7.2614 (15.3); 7.2228 (0.6); 7.2069 (0.7); 7.2039 (0.8); 1.8255 (16.0); -δ = 7.6638 (0.5); 7.4143 (1.7); 7.4021 (1.7); 7.2614 (15.3); 7.2228 (0.6); 7.2069 (0.7); 7.2039 (0.8); 1.8255 (16.0); -

0.0002 (5.3) 0.0002 (5.3)

1.29-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.29-1: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7127 (3.8); 7.4087 (0.8); 7.2601 (26.2); 7.0469 (1.1); 7.0281 (1.3); 7.0260 (1.2); 7.0072 (1.0); 2.7152 (0.6); 2.7057 (0.6); 2.1697 (1.7); 1.8554 (16.0); 1.5481 (8.3); 0.7329 (0.9); 0.7294 (1.2); 0.7153 (1.1); 0.7115 (0.9); 0.4238δ = 7.7127 (3.8); 7.4087 (0.8); 7.2601 (26.2); 7.0469 (1.1); 7.0281 (1.3); 7.0260 (1.2); 7.0072 (1.0); 2.7152 (0.6); 2.7057 (0.6); 2.1697 (1.7); 1.8554 (16.0); 1.5481 (8.3); 0.7329 (0.9); 0.7294 (1.2); 0.7153 (1.1); 0.7115 (0.9); 0.4238

(0.8); 0.4208 (0.9); 0.4173 (0.9); 0.4110 (0.9); 0.4076 (0.8); -0.0002 (9.6) (0.8); 0.4208 (0.9); 0.4173 (0.9); 0.4110 (0.9); 0.4076 (0.8); -0.0002 (9.6)

1.29-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.29-1: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7127 (4.3); 7.4086 (0.8); 7.3875 (0.5); 7.2602 (20.2); 7.2545 (0.6); 7.0469 (1.1); 7.0281 (1.2); 7.0258 (1.2); 7.0071 (1.0); 2.7153 (0.6); 2.7057 (0.6); 1.8554 (16.0); 0.7328 (0.8); 0.7294 (1.3); 0.7265 (0.6); 0.7151 (1.1); 0.7114 (1.0); 0.7085 (0.6); 0.4238 (0.8); 0.4207 (0.9); 0.4173 (0.9); 0.4147 (0.8); 0.4110 (0.9); 0.4076 (0.9); -0.0002 (9.2) I.29-3: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.7127 (4.3); 7.4086 (0.8); 7.3875 (0.5); 7.2602 (20.2); 7.2545 (0.6); 7.0469 (1.1); 7.0281 (1.2); 7.0258 (1.2); 7.0071 (1.0); 2.7153 (0.6); 2.7057 (0.6); 1.8554 (16.0); 0.7328 (0.8); 0.7294 (1.3); 0.7265 (0.6); 0.7151 (1.1); 0.7114 (1.0); 0.7085 (0.6); 0.4238 (0.8); 0.4207 (0.9); 0.4173 (0.9); 0.4147 (0.8); 0.4110 (0.9); 0.4076 (0.9); -0.0002 (9.2) I.29-3: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7148 (4.3); 7.4327 (0.8); 7.4115 (0.5); 7.2600 (40.8); 7.0657 (1.2); 7.0467 (1.4); 7.0448 (1.3); 7.0257 (1.1); 1.8682 (16.0); 1.5435 (4.2); 1.5326 (1.2); 1.5173 (1.6); 1.5116 (1.7); 1.5088 (1.0); 1.4971 (0.9); 1.1524 (0.8); 1.1406 (0.9); 1.1378 (1.5); 1.1321 (1.5); 1.1168 (0.7); -0.0002 (14.5); -0.0085 (0.5) 1.29-4: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.7148 (4.3); 7.4327 (0.8); 7.4115 (0.5); 7.2600 (40.8); 7.0657 (1.2); 7.0467 (1.4); 7.0448 (1.3); 7.0257 (1.1); 1.8682 (16.0); 1.5435 (4.2); 1.5326 (1.2); 1.5173 (1.6); 1.5116 (1.7); 1.5088 (1.0); 1.4971 (0.9); 1.1524 (0.8); 1.1406 (0.9); 1.1378 (1.5); 1.1321 (1.5); 1.1168 (0.7); -0.0002 (14.5); -0.0085 (0.5) 1.29-4: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7371 (3.8); 7.4094 (0.8); 7.2600 (33.4); 7.1066 (0.7); 7.0441 (1.2); 7.0255 (1.4); 7.0046 (1.1); 4.1304 (0.8); 4.1125 (2.6); 4.0947 (2.7); 4.0768 (0.8); 1.8834 (16.0); 1.5456 (5.7); 1.5304 (0.9); 1.5182 (2.2); 1.5100 (2.2); 1.4985 (0.9); 1.2237 (2.7); 1.2058 (5.5); 1.1880 (2.6); 1.0548 (0.9); 1.0432 (2.1); 1.0351 (2.1); 1.0229 (0.7); -0.0002 (12.4) 1.29-101 : 1 H-NMR(400.0 MHz, CDCI3): δ = 7.7371 (3.8); 7.4094 (0.8); 7.2600 (33.4); 7.1066 (0.7); 7.0441 (1.2); 7.0255 (1.4); 7.0046 (1.1); 4.1304 (0.8); 4.1125 (2.6); 4.0947 (2.7); 4.0768 (0.8); 1.8834 (16.0); 1.5456 (5.7); 1.5304 (0.9); 1.5182 (2.2); 1,500 (2.2); 1.4985 (0.9); 1.2237 (2.7); 1.2058 (5.5); 1.1880 (2.6); 1.0548 (0.9); 1.0432 (2.1); 1.0351 (2.1); 1.0229 (0.7); -0.0002 (12.4) 1.29-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6306 (3.6); 7.3713 (0.8); 7.2600 (32.8); 7.0019 (1.1); 6.9837 (1.1); 6.9809 (1.1); 6.9627 (0.9); 3.5314 (0.8);δ = 7.6306 (3.6); 7.3713 (0.8); 7.2600 (32.8); 7.0019 (1.1); 6.9837 (1.1); 6.9809 (1.1); 6.9627 (0.9); 3.5314 (0.8);

2.6476 (0.9); 1.8343 (16.0); 1.7647 (0.8); 1.7539 (1.0); 1.5488 (5.7); -0.0002 (11.8) 2.6476 (0.9); 1.8343 (16.0); 1.7647 (0.8); 1.7539 (1.0); 1.5488 (5.7); -0.0002 (11.8)

1.29-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.29-101: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6307 (3.1); 7.3711 (0.8); 7.3502 (0.5); 7.2603 (16.5); 7.2592 (16.1); 7.0007 (1.3); 6.9812 (1.7); 6.9624 (1.1); 3.5465 (0.8); 3.5298 (1.3); 3.5138 (0.7); 2.6606 (0.7); 2.6467 (1.4); 2.6309 (0.8); 1.8336 (16.0); 1.7532 (1.8); 1.5563δ = 7.6307 (3.1); 7.3711 (0.8); 7.3502 (0.5); 7.2603 (16.5); 7.2592 (16.1); 7,0007 (1.3); 6.9812 (1.7); 6.9624 (1.1); 3.5465 (0.8); 3.5298 (1.3); 3.5138 (0.7); 2.6606 (0.7); 2.6467 (1.4); 2.6309 (0.8); 1.8336 (16.0); 1.7532 (1.8); 1.5563

(0.7); -0.0002 (7.4); -0.0013 (7.3) (0.7); -0.0002 (7.4); -0.0013 (7.3)

1.29-167: 1 H-NMR(400.0 MHz, CDCI3):  1.29-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5877 (3.5); 7.3729 (0.7); 7.2602 (24.9); 7.0054 (1.0); 6.9871 (1.1); 6.9844 (1.0); 6.9661 (0.9); 2.1698 (0.8);δ = 7.5877 (3.5); 7.3729 (0.7); 7.2602 (24.9); 7.0054 (1.0); 6.9871 (1.1); 6.9844 (1.0); 6.9661 (0.9); 2.1698 (0.8);

1.8417 (16.0); 1.5484 (4.4); -0.0002 (9.0) 1.8417 (16.0); 1.5484 (4.4); -0.0002 (9.0)

1.29-170: 1 H-NMR(400.0 MHz, CDCI3):  1.29-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7563 (4.0); 7.3994 (0.8); 7.2601 (27.0); 7.0366 (1.2); 7.0181 (1.3); 7.0157 (1.2); 6.9970 (1.1); 5.2984 (0.7);δ = 7.7563 (4.0); 7.3994 (0.8); 7.2601 (27.0); 7.0366 (1.2); 7.0181 (1.3); 7.0157 (1.2); 6.9970 (1.1); 5.2984 (0.7);

3.9682 (2.8); 3.9543 (2.8); 3.7155 (10.0); 2.1697 (1.5); 1.9002 (16.0); 1.5462 (6.8); -0.0002 (9.9) 3.9682 (2.8); 3.9543 (2.8); 3.7155 (10.0); 2.1697 (1.5); 1.9002 (16.0); 1.5462 (6.8); -0.0002 (9.9)

1.29-171 : 1 H-NMR(400.0 MHz, CDCI3):  1.29-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7224 (1.3); 7.3991 (0.8); 7.3937 (0.8); 7.3833 (0.5); 7.3780 (1.7); 7.3728 (0.6); 7.3620 (0.8); 7.3569 (1.0); 7.2646 (65.7); 7.0109 (2.4); 7.0003 (0.8); 6.9928 (2.7); 6.9901 (2.6); 6.9718 (2.2); 4.0712 (2.4); 3.7565 (4.3); 2.5939δ = 7.7224 (1.3); 7.3991 (0.8); 7.3937 (0.8); 7.3833 (0.5); 7.3780 (1.7); 7.3728 (0.6); 7.3620 (0.8); 7.3569 (1.0); 7.2646 (65.7); 7.0109 (2.4); 7,0003 (0.8); 6.9928 (2.7); 6.9901 (2.6); 6.9718 (2.2); 4.0712 (2.4); 3.7565 (4.3); 2.5939

(3.7); 2.5788 (0.7); 1.8639 (16.0); 1.8417 (0.6); 1.6542 (5.2); 0.0079 (0.7); -0.0002 (23.3); -0.0084 (0.7) (3.7); 2.5788 (0.7); 1.8639 (16.0); 1.8417 (0.6); 1.6542 (5.2); 0.0079 (0.7); -0.0002 (23.3); -0.0084 (0.7)

1.29-213: 1 H-NMR(400.0 MHz, CDCI3):  1.29-213: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7383 (4.1); 7.4295 (0.8); 7.2599 (37.3); 7.0666 (1.2); 7.0477 (1.3); 7.0457 (1.2); 7.0267 (1.0); 5.2985 (1.0);δ = 7.7383 (4.1); 7.4295 (0.8); 7.2599 (37.3); 7.0666 (1.2); 7.0477 (1.3); 7.0457 (1.2); 7.0267 (1.0); 5.2985 (1.0);

4.1117 (3.4); 4.0974 (3.4); 1.8913 (16.0); 1.5495 (0.5); 1.5408 (8.5); -0.0002 (13.7) 4.1117 (3.4); 4.0974 (3.4); 1.8913 (16.0); 1.5495 (0.5); 1.5408 (8.5); -0.0002 (13.7)

1.29-214: 1 H-NMR(400.0 MHz, CDCI3):  1.29-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6315 (4.4); 7.3882 (0.8); 7.2596 (38.3); 7.0152 (1.1); 6.9966 (1.2); 6.9941 (1.1); 6.9757 (1.0); 2.6898 (0.6);δ = 7.6315 (4.4); 7.3882 (0.8); 7.2596 (38.3); 7.0152 (1.1); 6.9966 (1.2); 6.9941 (1.1); 6.9757 (1.0); 2.6898 (0.6);

1.8906 (0.5); 1.8666 (16.0); 1.5351 (3.5); -0.0002 (13.8) 1.8906 (0.5); 1.8666 (16.0); 1.5351 (3.5); -0.0002 (13.8)

I.29-303: 1 H-NMR(400.0 MHz, CDCI3):  I.29-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6659 (3.6); 7.3582 (0.8); 7.2600 (27.0); 6.9887 (1.0); 6.9703 (1.1); 6.9677 (1.1); 6.9494 (0.9); 5.2985 (1.5);δ = 7.6659 (3.6); 7.3582 (0.8); 7.2600 (27.0); 6,987 (1.0); 6.9703 (1.1); 6.9677 (1.1); 6.9494 (0.9); 5.2985 (1.5);

3.1769 (9.0); 3.0651 (6.9); 2.1697 (1.1); 1.8396 (16.0); 1.5443 (7.2); -0.0002 (9.7) 3.1769 (9.0); 3.0651 (6.9); 2.1697 (1.1); 1.8396 (16.0); 1.5443 (7.2); -0.0002 (9.7)

I.29-353: 1 H-NMR(400.0 MHz, CDCI3):  I.29-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3681 (0.6); 7.7328 (4.6); 7.4258 (0.8); 7.2606 (18.3); 7.0579 (1.2); 7.0391 (1.4); 7.0369 (1.2); 7.0180 (1.1); 3.9203 (1.2); 3.9094 (1.5); 3.9022 (0.6); 3.8982 (1.4); 3.8910 (0.6); 3.6626 (0.6); 3.6512 (0.7); 3.6461 (0.8); 3.6405 (0.7); 3.6353 (0.5); 1.9238 (0.6); 1.9051 (16.0); 1.5707 (2.0); -0.0002 (9.1) δ = 9.3681 (0.6); 7.7328 (4.6); 7.4258 (0.8); 7.2606 (18.3); 7.0579 (1.2); 7.0391 (1.4); 7.0369 (1.2); 7.0180 (1.1); 3.9203 (1.2); 3.9094 (1.5); 3.9022 (0.6); 3.8982 (1.4); 3.8910 (0.6); 3.6626 (0.6); 3.6512 (0.7); 3.6461 (0.8); 3.6405 (0.7); 3.6353 (0.5); 1.9238 (0.6); 1.9051 (16.0); 1.5707 (2.0); -0.0002 (9.1)

1.31- 167: 1 H-NMR(400.0 MHz, CDCI3):  1.31-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6092 (4.0); 7.3669 (0.9); 7.3526 (0.8); 7.3464 (0.7); 7.3324 (0.7); 7.3171 (0.8); 7.3135 (1.1); 7.2602 (24.8); 7.1154 (0.5); 7.1123 (0.5); 7.0944 (0.8); 7.0915 (0.6); 5.2984 (2.6); 1.8485 (16.0); 1.5464 (7.1); -0.0002 (8.9) δ = 7.6092 (4.0); 7.3669 (0.9); 7.3526 (0.8); 7.3464 (0.7); 7.3324 (0.7); 7.3171 (0.8); 7.3135 (1.1); 7.2602 (24.8); 7.1154 (0.5); 7.1123 (0.5); 7.0944 (0.8); 7.0915 (0.6); 5.2984 (2.6); 1.8485 (16.0); 1.5464 (7.1); -0.0002 (8.9)

1.32- 167: 1 H-NMR(400.0 MHz, CDCI3):  1.32-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5783 (0.8); 8.5667 (0.8); 7.5686 (3.6); 7.5227 (0.6); 7.5196 (0.9); 7.4989 (0.5); 7.4954 (0.5); 7.3708 (0.6); 7.3695 (0.6); 7.3595 (0.8); 7.2616 (15.3); 1.8597 (16.0); -0.0002 (5.1) δ = 8.5783 (0.8); 8.5667 (0.8); 7.5686 (3.6); 7.5227 (0.6); 7.5196 (0.9); 7.4989 (0.5); 7.4954 (0.5); 7.3708 (0.6); 7.3695 (0.6); 7.3595 (0.8); 7.2616 (15.3); 1.8597 (16.0); -0.0002 (5.1)

1.33- 2: 1 H-NMR(400.0 MHz, CDCI3):  1.33-2: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6645 (1.0); 8.6608 (1.0); 8.6529 (1.0); 8.6492 (1.0); 7.8668 (1.0); 7.8631 (1.0); 7.8463 (1.1); 7.8426 (1.1); 7.6919 (4.2); 7.3525 (1.1); 7.3408 (1.1); 7.3321 (1.0); 7.3204 (1.0); 7.2614 (15.9); 5.2985 (0.5); 1.8343 (16.0); 1.5738 (4.2); 1.3008 (6.2); 0.6187 (1.2); 0.6105 (1.2); 0.5846 (1.2); 0.5800 (1.2); 0.5779 (1.2); 0.5754 (1.4); -0.0002 (6.2) I.33-3: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6645 (1.0); 8.6608 (1.0); 8.6529 (1.0); 8.6492 (1.0); 7.8668 (1.0); 7.8631 (1.0); 7.8463 (1.1); 7.8426 (1.1); 7.6919 (4.2); 7.3525 (1.1); 7.3408 (1.1); 7.3321 (1.0); 7.3204 (1.0); 7.2614 (15.9); 5.2985 (0.5); 1.8343 (16.0); 1.5738 (4.2); 1.3008 (6.2); 0.6187 (1.2); 0.6105 (1.2); 0.5846 (1.2); 0.5800 (1.2); 0.5779 (1.2); 0.5754 (1.4); -0.0002 (6.2) I.33-3: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6908 (1.0); 8.6871 (1.1); 8.6789 (1.1); 8.6752 (1.1); 7.9444 (1.0); 7.9407 (1.1); 7.9239 (1.2); 7.9202 (1.1); 7.7083 (4.6); 7.4362 (1.2); 7.4243 (1.2); 7.4157 (1.4); 7.4038 (1.3); 7.2598 (53.3); 2.0446 (0.9); 1.8692 (16.0); 1.5176 (0.7); 1.5023 (1.4); 1.4966 (1.6); 1.4938 (0.9); 1.4821 (0.9); 1.2590 (0.7); 1.1539 (0.9); 1.1423 (0.8); 1.1394 (1.5);δ = 8.6908 (1.0); 8.6871 (1.1); 8.6789 (1.1); 8.6752 (1.1); 7.9444 (1.0); 7.9407 (1.1); 7.9239 (1.2); 7.9202 (1.1); 7.7083 (4.6); 7.4362 (1.2); 7.4243 (1.2); 7.4157 (1.4); 7.4038 (1.3); 7.2598 (53.3); 2.0446 (0.9); 1.8692 (16.0); 1.5176 (0.7); 1.5023 (1.4); 1.4966 (1.6); 1.4938 (0.9); 1.4821 (0.9); 1.2590 (0.7); 1.1539 (0.9); 1.1423 (0.8); 1.1394 (1.5);

1.1337 (1.5); 1.1184 (0.7); 0.0080 (0.6); -0.0002 (20.7); -0.0085 (0.6) 1.1337 (1.5); 1.1184 (0.7); 0.0080 (0.6); -0.0002 (20.7); -0.0085 (0.6)

1.33-17: 1 H-NMR(400.0 MHz, CDCI3):  1.33-17: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6617 (0.9); 8.6581 (0.9); 8.6500 (1.0); 8.6464 (0.9); 7.8759 (0.9); 7.8722 (0.9); 7.8554 (1.0); 7.8518 (1.0); 7.7080 (3.7); 7.3617 (1.0); 7.3500 (1.0); 7.3413 (0.9); 7.3295 (0.9); 7.2601 (28.2); 7.1665 (0.5); 2.7751 (5.1); 1.8586δ = 8.6617 (0.9); 8.6581 (0.9); 8.6500 (1.0); 8.6464 (0.9); 7.8759 (0.9); 7.8722 (0.9); 7.8554 (1.0); 7.8518 (1.0); 7.7080 (3.7); 7.3617 (1.0); 7.3500 (1.0); 7.3413 (0.9); 7.3295 (0.9); 7.2601 (28.2); 7.1665 (0.5); 2.7751 (5.1); 1.8586

(16.0); 0.8876 (1.7); 0.8825 (1.0); 0.8740 (1.0); 0.8263 (0.9); 0.8130 (1.6); -0.0002 (12.0) (16.0); 0.8876 (1.7); 0.8825 (1.0); 0.8740 (1.0); 0.8263 (0.9); 0.8130 (1.6); -0.0002 (12.0)

I.33-59: 1 H-NMR(400.0 MHz, CDCI3):  I.33-59: 1H-NMR (400.0 MHz, CDCl3):

δ= 8.7065 (0.5); 8.6995 (1.2); 8.6959 (1.2); 8.6878 (1.1); 8.6842 (1.2); 7.9030 (1.0); 7.8993 (1.0); 7.8826 (1.1); 7.8789 (1.1); 7.7892 (4.1); 7.6401 (0.8); 7.6351 (1.6); 7.6302 (0.9); 7.3956 (1.1); 7.3839 (1.1); 7.3751 (1.0); 7.3635 (1.0); 7.3187 (0.5); 7.3161 (0.5); 7.3136 (0.5); 7.3008 (0.6); 7.2983 (0.7); 7.2958 (0.8); 7.2933 (0.7); 7.2596 (50.4); 7.2237 (1.2); 7.2037 (1.7); 7.1834 (0.9); 7.0822 (0.6); 7.0798 (0.7); 7.0773 (0.7); 7.0747 (0.7); 7.0623 (0.5); 7.0599δ = 8.7065 (0.5); 8.6995 (1.2); 8.6959 (1.2); 8.6878 (1.1); 8.6842 (1.2); 7.9030 (1.0); 7.8993 (1.0); 7.8826 (1.1); 7.8789 (1.1); 7.7892 (4.1); 7.6401 (0.8); 7.6351 (1.6); 7.6302 (0.9); 7.3956 (1.1); 7.3839 (1.1); 7.3751 (1.0); 7.3635 (1.0); 7.3187 (0.5); 7.3161 (0.5); 7.3136 (0.5); 7.3008 (0.6); 7.2983 (0.7); 7.2958 (0.8); 7.2933 (0.7); 7.2596 (50.4); 7.2237 (1.2); 7.2037 (1.7); 7.1834 (0.9); 7.0822 (0.6); 7.0798 (0.7); 7.0773 (0.7); 7.0747 (0.7); 7.0623 (0.5); 7.0599

(0.6); 7.0574 (0.6); 7.0548 (0.5); 1.9686 (16.0); 1.5574 (1.0); 0.0081 (0.7); -0.0002 (21.3); -0.0084 (1.1) (0.6); 7.0574 (0.6); 7.0548 (0.5); 1.9686 (16.0); 1.5574 (1.0); 0.0081 (0.7); -0.0002 (21.3); -0.0084 (1.1)

I.33-63: 1 H-NMR(400.0 MHz, CDCI3):  I.33-63: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7111 (1.1); 8.7074 (1.2); 8.6994 (1.2); 8.6957 (1.2); 7.9221 (1.0); 7.9193 (1.1); 7.9089 (1.2); 7.9052 (1.2); 7.8885 (1.3); 7.8848 (1.2); 7.7941 (5.0); 7.7250 (1.3); 7.6972 (0.6); 7.6920 (0.5); 7.6808 (0.9); 7.6751 (0.5); 7.5182 (1.5); 7.4094 (1.4); 7.3978 (1.4); 7.3923 (1.1); 7.3890 (1.3); 7.3841 (1.1); 7.3806 (1.2); 7.3772 (3.5); 7.3747 (2.0); 7.3086 (0.5); 7.2593 (273.4); 7.2091 (0.7); 6.9953 (1.5); 1.9761 (16.0); 1.8754 (4.7); 1.5348 (6.0); 1.2556 (1.6); 1.0735 (0.8); 1.0552 (1.6); 1.0371 (0.7); 0.0079 (3.0); -0.0002 (102.9); -0.0085 (3.0) 1.33-101 : 1 H-NMR(400.0 MHz, CDCI3): δ = 8.7111 (1.1); 8.7074 (1.2); 8.6994 (1.2); 8.6957 (1.2); 7.9221 (1.0); 7.9193 (1.1); 7.9089 (1.2); 7.9052 (1.2); 7.8885 (1.3); 7.8848 (1.2); 7.7941 (5.0); 7.7250 (1.3); 7.6972 (0.6); 7.6920 (0.5); 7.6808 (0.9); 7.6751 (0.5); 7.5182 (1.5); 7.4094 (1.4); 7.3978 (1.4); 7.3923 (1.1); 7.3890 (1.3); 7.3841 (1.1); 7.3806 (1.2); 7.3772 (3.5); 7.3747 (2.0); 7.3086 (0.5); 7.2593 (273.4); 7.2091 (0.7); 6.9953 (1.5); 1.9761 (16.0); 1.8754 (4.7); 1.5348 (6.0); 1.2556 (1.6); 1.0735 (0.8); 1.0552 (1.6); 1.0371 (0.7); 0.0079 (3.0); -0.0002 (102.9); -0.0085 (3.0) 1.33-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6481 (1.0); 8.6444 (1.0); 8.6364 (1.0); 8.6327 (1.1); 7.8359 (1.0); 7.8322 (1.1); 7.8156 (1.2); 7.8118 (1.2); 7.6089 (4.4); 7.3282 (1.1); 7.3165 (1.2); 7.3078 (1.1); 7.2961 (1.1); 7.2616 (19.2); 3.5326 (0.8); 2.9548 (0.6); 2.8840 (0.5); 2.8826 (0.5); 2.7221 (0.8); 1.8470 (16.0); 1.7576 (0.8); 1.7477 (1.0); 1.7421 (1.0); 1.7323 (0.8); -0.0002 (7.6) 1.33-102: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6481 (1.0); 8.6444 (1.0); 8.6364 (1.0); 8.6327 (1.1); 7.8359 (1.0); 7.8322 (1.1); 7.8156 (1.2); 7.8118 (1.2); 7.6089 (4.4); 7.3282 (1.1); 7.3165 (1.2); 7.3078 (1.1); 7.2961 (1.1); 7.2616 (19.2); 3.5326 (0.8); 2.9548 (0.6); 2.8840 (0.5); 2.8826 (0.5); 2.7221 (0.8); 1.8470 (16.0); 1.7576 (0.8); 1.7477 (1.0); 1.7421 (1.0); 1.7323 (0.8); -0.0002 (7.6) 1.33-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6494 (1.8); 8.6457 (1.9); 8.6377 (1.9); 8.6340 (1.9); 7.8385 (1.9); 7.8348 (2.0); 7.8181 (2.2); 7.8144 (2.0); 7.5818 (9.2); 7.5187 (0.7); 7.3286 (2.2); 7.3169 (2.1); 7.3082 (2.0); 7.2965 (2.0); 7.2599 (136.3); 6.9959 (0.8); 2.7641δ = 8.6494 (1.8); 8.6457 (1.9); 8.6377 (1.9); 8.6340 (1.9); 7.8385 (1.9); 7.8348 (2.0); 7.8181 (2.2); 7.8144 (2.0); 7.5818 (9.2); 7.5187 (0.7); 7.3286 (2.2); 7.3169 (2.1); 7.3082 (2.0); 7.2965 (2.0); 7.2599 (136.3); 6.9959 (0.8); 2.7641

(1.2) ; 2.7462 (2.0); 2.7292 (0.8); 1.8791 (0.5); 1.8600 (0.5); 1.8506 (0.8); 1.8310 (16.0); 1.6855 (0.6); 1.6701 (0.6); 1.6550 (0.6); 1.5929 (0.8); 1.4479 (0.5); 1.2163 (5.7); 1.2006 (5.7); 0.0080 (1.7); 0.0056 (0.6); -0.0002 (59.3); -(1.2); 2.7462 (2.0); 2.7292 (0.8); 1.8791 (0.5); 1.8600 (0.5); 1.8506 (0.8); 1.8310 (16.0); 1.6855 (0.6); 1.6701 (0.6); 1.6550 (0.6); 1.5929 (0.8); 1.4479 (0.5); 1.2163 (5.7); 1.2006 (5.7); 0.0080 (1.7); 0.0056 (0.6); -0.0002 (59.3); -

0.0085 (1.6) 0.0085 (1.6)

1.33-108: 1 H-NMR(400.0 MHz, CDCI3):  1.33-108: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6536 (3.5); 8.6499 (3.7); 8.6419 (3.7); 8.6382 (3.6); 7.8393 (3.6); 7.8356 (3.6); 7.8189 (4.0); 7.8152 (3.7); 7.5608 (16.0); 7.5188 (1.2); 7.3273 (4.0); 7.3156 (3.9); 7.3096 (0.8); 7.3069 (3.6); 7.2952 (3.8); 7.2729 (0.6); 7.2721 (0.6); 7.2713 (0.7); 7.2705 (0.7); 7.2697 (0.8); 7.2689 (0.9); 7.2681 (1.1); 7.2673 (1.3); 7.2665 (1.6); 7.2657 (2.0); 7.2599 (205.7); 7.2503 (0.6); 6.9959 (1.2); 3.6498 (0.5); 2.0742 (1.0); 1.9271 (0.6); 1.8836 (3.1); 1.8669 (2.3); 1.8581δ = 8.6536 (3.5); 8.6499 (3.7); 8.6419 (3.7); 8.6382 (3.6); 7.8393 (3.6); 7.8356 (3.6); 7.8189 (4.0); 7.8152 (3.7); 7.5608 (16.0); 7.5188 (1.2); 7.3273 (4.0); 7.3156 (3.9); 7.3096 (0.8); 7.3069 (3.6); 7.2952 (3.8); 7.2729 (0.6); 7.2721 (0.6); 7.2713 (0.7); 7.2705 (0.7); 7.2697 (0.8); 7.2689 (0.9); 7.2681 (1.1); 7.2673 (1.3); 7.2665 (1.6); 7.2657 (2.0); 7.2599 (205.7); 7.2503 (0.6); 6.9959 (1.2); 3.6498 (0.5); 2.0742 (1.0); 1.9271 (0.6); 1.8836 (3.1); 1.8669 (2.3); 1.8581

(2.3) ; 1.8421 (3.5); 1.5879 (1.9); 1.4941 (0.7); 1.3425 (1.9); 0.8411 (1.8); 0.0080 (2.6); 0.0056 (0.9); 0.0048 (1.1); -(2.3); 1.8421 (3.5); 1.5879 (1.9); 1.4941 (0.7); 1.3425 (1.9); 0.8411 (1.8); 0.0080 (2.6); 0.0056 (0.9); 0.0048 (1.1); -

0.0002 (88.6); -0.0085 (2.5) 0.0002 (88.6); -0.0085 (2.5)

1.33-124: 1 H-NMR(400.0 MHz, CDCI3):  1.33-124: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6774 (0.9); 8.6737 (1.0); 8.6656 (1.0); 8.6619 (1.0); 7.8649 (1.0); 7.8612 (1.0); 7.8445 (1.1); 7.8408 (1.0); 7.5494 (3.9); 7.3572 (1.1); 7.3454 (1.0); 7.3368 (1.0); 7.3250 (1.0); 7.2613 (15.8); 5.2985 (0.6); 1.8435 (16.0); 1.5421δ = 8.6774 (0.9); 8.6737 (1.0); 8.6656 (1.0); 8.6619 (1.0); 7.8649 (1.0); 7.8612 (1.0); 7.8445 (1.1); 7.8408 (1.0); 7.5494 (3.9); 7.3572 (1.1); 7.3454 (1.0); 7.3368 (1.0); 7.3250 (1.0); 7.2613 (15.8); 5.2985 (0.6); 1.8435 (16.0); 1.5421

(0.7); -0.0002 (6.2) (0.7); -0.0002 (6.2)

1.33-133: 1 H-NMR(400.0 MHz, CDCI3):  1.33-133: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6506 (1.5); 8.6469 (1.6); 8.6389 (1.5); 8.6351 (1.5); 7.8398 (1.5); 7.8361 (1.5); 7.8194 (1.6); 7.8157 (1.6); 7.5496 (6.2); 7.3323 (1.6); 7.3206 (1.6); 7.3119 (1.5); 7.3002 (1.5); 7.2601 (71.0); 4.1454 (1.2); 4.1275 (3.8); 4.1097 (3.8); 4.0919 (1.2); 2.8242 (0.5); 2.4331 (0.7); 1.8455 (16.0); 1.5710 (1.4); 1.2512 (4.1); 1.2334 (8.6); 1.2155 (4.1);δ = 8.6506 (1.5); 8.6469 (1.6); 8.6389 (1.5); 8.6351 (1.5); 7.8398 (1.5); 7.8361 (1.5); 7.8194 (1.6); 7.8157 (1.6); 7.5496 (6.2); 7.3323 (1.6); 7.3206 (1.6); 7.3119 (1.5); 7.3002 (1.5); 7.2601 (71.0); 4.1454 (1.2); 4.1275 (3.8); 4.1097 (3.8); 4.0919 (1.2); 2.8242 (0.5); 2.4331 (0.7); 1.8455 (16.0); 1.5710 (1.4); 1.2512 (4.1); 1.2334 (8.6); 1.2155 (4.1);

0.0080 (0.7); -0.0002 (29.9); -0.0085 (1.2) 0.0080 (0.7); -0.0002 (29.9); -0.0085 (1.2)

1.33-135: 1 H-NMR(400.0 MHz, CDCI3):  1.33-135: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6519 (1.2); 8.6481 (1.2); 8.6402 (1.3); 8.6365 (1.3); 7.8393 (1.3); 7.8356 (1.3); 7.8189 (1.4); 7.8152 (1.4); 7.5445 (5.5); 7.3311 (1.4); 7.3195 (1.4); 7.3107 (1.4); 7.2990 (1.3); 7.2603 (45.6); 7.2528 (0.7); 7.2520 (0.7); 7.2504 (0.6); 7.2496 (0.5); 3.3404 (0.6); 3.3312 (0.5); 3.3002 (16.0); 1.8453 (15.8); 1.5866 (0.6); 0.0080 (0.5); -0.0002δ = 8.6519 (1.2); 8.6481 (1.2); 8.6402 (1.3); 8.6365 (1.3); 7.8393 (1.3); 7.8356 (1.3); 7.8189 (1.4); 7.8152 (1.4); 7.5445 (5.5); 7.3311 (1.4); 7.3195 (1.4); 7.3107 (1.4); 7.2990 (1.3); 7.2603 (45.6); 7.2528 (0.7); 7.2520 (0.7); 7.2504 (0.6); 7.2496 (0.5); 3.3404 (0.6); 3.3312 (0.5); 3.3002 (16.0); 1.8453 (15.8); 1.5866 (0.6); 0.0080 (0.5); -0.0002

(20.2); -0.0085 (0.8) (20.2); -0.0085 (0.8)

1.33-150: 1 H-NMR(400.0 MHz, CDCI3):  1.33-150: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6336 (1.0); 8.6299 (1.0); 8.6219 (1.0); 8.6182 (1.0); 7.8160 (1.1); 7.8122 (1.0); 7.7956 (1.2); 7.7918 (1.1); 7.6385 (4.6); 7.3017 (1.2); 7.2899 (1.2); 7.2812 (1.1); 7.2696 (1.2); 7.2601 (36.3); 3.7496 (0.8); 3.7352 (0.6); 3.3700 (0.6); 3.3563 (0.9); 3.3454 (0.5); 1.8586 (16.0); 1.6641 (0.6); 1.6487 (1.3); 1.6438 (1.0); 1.6345 (0.8); 1.6210 (0.5); -δ = 8.6336 (1.0); 8.6299 (1.0); 8.6219 (1.0); 8.6182 (1.0); 7.8160 (1.1); 7.8122 (1.0); 7.7956 (1.2); 7.7918 (1.1); 7.6385 (4.6); 7.3017 (1.2); 7.2899 (1.2); 7.2812 (1.1); 7.2696 (1.2); 7.2601 (36.3); 3.7496 (0.8); 3.7352 (0.6); 3.3700 (0.6); 3.3563 (0.9); 3.3454 (0.5); 1.8586 (16.0); 1.6641 (0.6); 1.6487 (1.3); 1.6438 (1.0); 1.6345 (0.8); 1.6210 (0.5); -

0.0002 (14.9) 0.0002 (14.9)

1.33-152: 1 H-NMR(400.0 MHz, CDCI3):  1.33-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6953 (1.0); 8.6916 (1.0); 8.6834 (1.0); 8.6797 (1.0); 7.8897 (1.0); 7.8860 (1.0); 7.8692 (1.1); 7.8655 (1.1); 7.5911 (4.1); 7.3919 (1.1); 7.3800 (1.1); 7.3714 (1.0); 7.3595 (1.0); 7.2612 (16.3); 5.2984 (1.0); 2.0443 (1.0); 1.9068δ = 8.6953 (1.0); 8.6916 (1.0); 8.6834 (1.0); 8.6797 (1.0); 7.8897 (1.0); 7.8860 (1.0); 7.8692 (1.1); 7.8655 (1.1); 7.5911 (4.1); 7.3919 (1.1); 7.3800 (1.1); 7.3714 (1.0); 7.3595 (1.0); 7.2612 (16.3); 5.2984 (1.0); 2.0443 (1.0); 1.9068

(0.6); 1.8550 (16.0); 1.2588 (0.6); -0.0002 (6.4) (0.6); 1.8550 (16.0); 1.2588 (0.6); -0.0002 (6.4)

1.33-167: 1 H-NMR(400.0 MHz, CDCI3):  1.33-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6479 (0.8); 8.6444 (1.0); 8.6362 (0.9); 8.6327 (0.9); 7.8322 (0.8); 7.8286 (0.9); 7.8118 (0.9); 7.8082 (1.0); 7.5611 (3.2); 7.3241 (0.9); 7.3124 (0.9); 7.3037 (0.9); 7.2920 (0.8); 7.2606 (18.9); 1.8531 (16.0); 1.5529 (2.2); -δ = 8.6479 (0.8); 8.6444 (1.0); 8.6362 (0.9); 8.6327 (0.9); 7.8322 (0.8); 7.8286 (0.9); 7.8118 (0.9); 7.8082 (1.0); 7.5611 (3.2); 7.3241 (0.9); 7.3124 (0.9); 7.3037 (0.9); 7.2920 (0.8); 7.2606 (18.9); 1.8531 (16.0); 1.5529 (2.2); -

0.0002 (7.0) 0.0002 (7.0)

1.33-213: 1 H-NMR(400.0 MHz, CDCI3):  1.33-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6925 (1.0); 8.6888 (1.0); 8.6807 (1.0); 8.6770 (1.0); 7.9345 (1.0); 7.9308 (1.0); 7.9140 (1.1); 7.9103 (1.1); 7.7405 (4.4); 7.4218 (1.1); 7.4099 (1.1); 7.4013 (1.0); 7.3894 (1.0); 7.2609 (16.0); 5.2987 (0.9); 4.1098 (3.4); 4.0955δ = 8.6925 (1.0); 8.6888 (1.0); 8.6807 (1.0); 8.6770 (1.0); 7.9345 (1.0); 7.9308 (1.0); 7.9140 (1.1); 7.9103 (1.1); 7.7405 (4.4); 7.4218 (1.1); 7.4099 (1.1); 7.4013 (1.0); 7.3894 (1.0); 7.2609 (16.0); 5.2987 (0.9); 4.1098 (3.4); 4.0955

(3.3); 1.8984 (16.0); -0.0002 (5.7) (3.3); 1.8984 (16.0); -0.0002 (5.7)

1.33-214: 1 H-NMR(400.0 MHz, CDCI3):  1.33-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7294 (0.8); 8.7258 (0.8); 8.7174 (0.8); 8.7137 (0.8); 7.9351 (0.9); 7.9314 (0.9); 7.9146 (1.0); 7.9109 (1.0); 7.6151 (3.9); 7.4384 (0.9); 7.4263 (0.9); 7.4179 (0.9); 7.4058 (0.8); 7.2610 (14.9); 5.2986 (1.2); 2.7349 (0.7); 1.8764δ = 8.7294 (0.8); 8.7258 (0.8); 8.7174 (0.8); 8.7137 (0.8); 7.9351 (0.9); 7.9314 (0.9); 7.9146 (1.0); 7.9109 (1.0); 7.6151 (3.9); 7.4384 (0.9); 7.4263 (0.9); 7.4179 (0.9); 7.4058 (0.8); 7.2610 (14.9); 5.2986 (1.2); 2.7349 (0.7); 1.8764

(16.0); 1.2563 (0.8); -0.0002 (5.6) (16.0); 1.2563 (0.8); -0.0002 (5.6)

I.33-227: 1 H-NMR(400.0 MHz, CDCI3):  I.33-227: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6835 (0.8); 8.6798 (0.9); 8.6716 (0.9); 8.6680 (0.9); 7.9162 (1.0); 7.9126 (1.0); 7.8957 (1.1); 7.8921 (1.0); 7.7397 (4.4); 7.4029 (1.0); 7.3910 (1.0); 7.3824 (0.9); 7.3706 (0.9); 7.2612 (17.0); 3.4697 (0.6); 3.4530 (1.6); 3.4376δ = 8.6835 (0.8); 8.6798 (0.9); 8.6716 (0.9); 8.6680 (0.9); 7.9162 (1.0); 7.9126 (1.0); 7.8957 (1.1); 7.8921 (1.0); 7.7397 (4.4); 7.4029 (1.0); 7.3910 (1.0); 7.3824 (0.9); 7.3706 (0.9); 7.2612 (17.0); 3.4697 (0.6); 3.4530 (1.6); 3.4376

(1.6); 3.4210 (0.7); 2.5947 (1.4); 2.5780 (3.1); 2.5612 (1.4); 1.8897 (16.0); -0.0002 (6.4) (1.6); 3.4210 (0.7); 2.5947 (1.4); 2.5780 (3.1); 2.5612 (1.4); 1.8897 (16.0); -0.0002 (6.4)

I.33-228: 1 H-NMR(400.0 MHz, CDCI3):  I.33-228: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6830 (1.0); 8.6793 (1.1); 8.6711 (1.1); 8.6674 (1.1); 7.8823 (1.1); 7.8785 (1.1); 7.8618 (1.2); 7.8581 (1.2); 7.6314 (4.4); 7.3805 (1.2); 7.3686 (1.1); 7.3600 (1.1); 7.3482 (1.1); 7.2603 (30.3); 3.5941 (0.5); 2.6879 (1.3); 1.8754δ = 8.6830 (1.0); 8.6793 (1.1); 8.6711 (1.1); 8.6674 (1.1); 7.8823 (1.1); 7.8785 (1.1); 7.8618 (1.2); 7.8581 (1.2); 7.6314 (4.4); 7.3805 (1.2); 7.3686 (1.1); 7.3600 (1.1); 7.3482 (1.1); 7.2603 (30.3); 3.5941 (0.5); 2.6879 (1.3); 1.8754

(0.6); 1.8622 (16.0); -0.0002 (11.7) (0.6); 1.8622 (16.0); -0.0002 (11.7)

I.33-323: 1 H-NMR(400.0 MHz, CDCI3):  I.33-323: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7789 (0.7); 8.7701 (0.6); 8.6508 (1.0); 8.6472 (1.1); 8.6391 (1.1); 8.6355 (1.0); 8.0488 (0.6); 7.8556 (1.0); 7.8520 (0.9); 7.8351 (1.0); 7.8315 (1.0); 7.7573 (5.9); 7.3475 (1.0); 7.3358 (0.9); 7.3271 (0.9); 7.3154 (0.8); 7.2625 (15.5); 5.2986 (7.4); 2.0431 (0.6); 1.9955 (8.4); 1.9173 (16.0); 1.7121 (1.1); 1.2580 (0.7); -0.0002 (6.1) 1.33- 353: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 8.7789 (0.7); 8.7701 (0.6); 8.6508 (1.0); 8.6472 (1.1); 8.6391 (1.1); 8.6355 (1.0); 8.0488 (0.6); 7.8556 (1.0); 7.8520 (0.9); 7.8351 (1.0); 7.8315 (1.0); 7.7573 (5.9); 7.3475 (1.0); 7.3358 (0.9); 7.3271 (0.9); 7.3154 (0.8); 7.2625 (15.5); 5.2986 (7.4); 2.0431 (0.6); 1.9955 (8.4); 1.9173 (16.0); 1.7121 (1.1); 1.2580 (0.7); -0.0002 (6.1) 1.33-353: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 11.1536 (1.6); 8.6381 (1.9); 8.6345 (2.0); 8.6265 (2.0); 8.6228 (2.0); 8.2376 (5.8); 8.0769 (1.9); 8.0733 (2.0); 8.0564 (2.2); 8.0528 (2.0); 7.5302 (2.3); 7.5185 (2.1); 7.5096 (2.0); 7.4980 (2.1); 5.7534 (1.0); 4.6205 (0.8); 4.6060 (1.9); 4.5916 (0.9); 3.7778 (1.1); 3.7657 (1.9); 3.7530 (1.3); 3.5267 (0.8); 3.5132 (1.7); 3.5011 (1.5); 3.4875 (0.6); 3.3122 (30.3); 2.5234 (0.9); 2.5187 (1.3); 2.5100 (15.0); 2.5054 (31.2); 2.5008 (42.9); 2.4963 (29.2); 2.4917 (13.1); 1.9881 (0.8); 1.7361 (16.0); 0.9939 (0.5); 0.9910 (0.5) δ = 11.1536 (1.6); 8.6381 (1.9); 8.6345 (2.0); 8.6265 (2.0); 8.6228 (2.0); 8.2376 (5.8); 8.0769 (1.9); 8.0733 (2.0); 8.0564 (2.2); 8.0528 (2.0); 7.5302 (2.3); 7.5185 (2.1); 7.5096 (2.0); 7.4980 (2.1); 5.7534 (1.0); 4.6205 (0.8); 4.6060 (1.9); 4.5916 (0.9); 3.7778 (1.1); 3.7657 (1.9); 3.7530 (1.3); 3.5267 (0.8); 3.5132 (1.7); 3.5011 (1.5); 3.4875 (0.6); 3.3122 (30.3); 2.5234 (0.9); 2.5187 (1.3); 2,5100 (15.0); 2.5054 (31.2); 2,5008 (42.9); 2.4963 (29.2); 2.4917 (13.1); 1.9881 (0.8); 1.7361 (16.0); 0.9939 (0.5); 0.9910 (0.5)

1.34- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.34-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.6948 (0.9); 8.6912 (0.9); 8.6832 (0.9); 8.6796 (0.9); 8.0406 (0.9); 8.0370 (0.9); 8.0203 (1.0); 8.0167 (1.0); 7.7027 (3.7); 7.2728 (1.0); 7.2626 (9.0); 7.2525 (1.0); 7.2409 (0.9); 2.6541 (0.6); 2.6456 (0.6); 2.0432 (0.5); 1.8934 (0.8); 1.8594 (16.0); 1.5997 (0.8); 0.7217 (1.0); 0.7182 (1.3); 0.7043 (1.3); 0.7004 (1.0); 0.4137 (0.9); 0.4107 (1.0);δ = 8.6948 (0.9); 8.6912 (0.9); 8.6832 (0.9); 8.6796 (0.9); 8.0406 (0.9); 8.0370 (0.9); 8.0203 (1.0); 8.0167 (1.0); 7.7027 (3.7); 7.2728 (1.0); 7.2626 (9.0); 7.2525 (1.0); 7.2409 (0.9); 2.6541 (0.6); 2.6456 (0.6); 2.0432 (0.5); 1.8934 (0.8); 1.8594 (16.0); 1.5997 (0.8); 0.7217 (1.0); 0.7182 (1.3); 0.7043 (1.3); 0.7004 (1.0); 0.4137 (0.9); 0.4107 (1.0);

0.4072 (1.1); 0.4011 (1.0); 0.3975 (1.0); -0.0002 (3.1) 0.4072 (1.1); 0.4011 (1.0); 0.3975 (1.0); -0.0002 (3.1)

1.34-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.34-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6810 (0.9); 8.6774 (1.0); 8.6694 (1.0); 8.6657 (1.0); 8.0123 (1.0); 8.0087 (1.0); 7.9920 (1.1); 7.9883 (1.0); 7.6021 (4.0); 7.2611 (19.7); 7.2401 (1.2); 7.2285 (1.1); 7.2198 (1.0); 7.2082 (1.0); 3.5345 (1.0); 2.7519 (1.0); 2.7366 (0.5); 1.8829 (0.7); 1.8468 (16.0); 1.7600 (0.8); 1.7498 (1.1); 1.7440 (1.1); 1.7341 (0.8); 1.5650 (1.3); -0.0002 (7.2) 1.34-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6810 (0.9); 8.6774 (1.0); 8.6694 (1.0); 8.6657 (1.0); 8.0123 (1.0); 8.0087 (1.0); 7.9920 (1.1); 7.9883 (1.0); 7.6021 (4.0); 7.2611 (19.7); 7.2401 (1.2); 7.2285 (1.1); 7.2198 (1.0); 7.2082 (1.0); 3.5345 (1.0); 2.7519 (1.0); 2.7366 (0.5); 1.8829 (0.7); 1.8468 (16.0); 1.7600 (0.8); 1.7498 (1.1); 1.7440 (1.1); 1.7341 (0.8); 1.5650 (1.3); -0.0002 (7.2) 1.34-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6862 (0.8); 8.6826 (0.9); 8.6746 (0.9); 8.6710 (0.9); 8.0189 (0.9); 8.0153 (0.9); 7.9985 (1.0); 7.9949 (1.0); 7.5762 (3.6); 7.2623 (10.1); 7.2558 (1.1); 7.2440 (0.9); 7.2353 (0.9); 7.2237 (0.9); 5.2985 (4.5); 1.8937 (0.6); 1.8556δ = 8.6862 (0.8); 8.6826 (0.9); 8.6746 (0.9); 8.6710 (0.9); 8.0189 (0.9); 8.0153 (0.9); 7.9985 (1.0); 7.9949 (1.0); 7.5762 (3.6); 7.2623 (10.1); 7.2558 (1.1); 7.2440 (0.9); 7.2353 (0.9); 7.2237 (0.9); 5.2985 (4.5); 1.8937 (0.6); 1.8556

(16.0); 1.5743 (0.6); 1.2580 (0.5); -0.0002 (3.7) (16.0); 1.5743 (0.6); 1.2580 (0.5); -0.0002 (3.7)

1.34-167: 1 H-NMR(400.0 MHz, CDCI3):  1.34-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6831 (0.8); 8.6794 (0.9); 8.6715 (0.8); 8.6678 (0.9); 8.0140 (0.8); 8.0103 (0.9); 7.9936 (0.9); 7.9900 (0.9); 7.5561 (3.4); 7.2620 (10.7); 7.2417 (0.9); 7.2301 (0.9); 7.2214 (0.9); 7.2098 (0.9); 1.8900 (0.7); 1.8524 (16.0); 1.5730δ = 8.6831 (0.8); 8.6794 (0.9); 8.6715 (0.8); 8.6678 (0.9); 8.0140 (0.8); 8.0103 (0.9); 7.9936 (0.9); 7.9900 (0.9); 7.5561 (3.4); 7.2620 (10.7); 7.2417 (0.9); 7.2301 (0.9); 7.2214 (0.9); 7.2098 (0.9); 1.8900 (0.7); 1.8524 (16.0); 1.5730

(1.3) ; -0.0002 (3.9) (1.3); -0.0002 (3.9)

1.34- 213: 1 H-NMR(400.0 MHz, CDCI3):  1.34-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7039 (0.9); 8.7003 (0.9); 8.6923 (0.9); 8.6887 (0.9); 8.0633 (0.9); 8.0596 (0.9); 8.0428 (1.0); 8.0392 (1.0); 7.7380 (3.7); 7.2948 (1.0); 7.2832 (1.0); 7.2744 (1.0); 7.2611 (13.5); 5.2987 (1.8); 4.1197 (3.4); 4.1054 (3.3); 1.9246 (0.7); 1.8959 (16.0); -0.0002 (4.8) δ = 8.7039 (0.9); 8.7003 (0.9); 8.6923 (0.9); 8.6887 (0.9); 8.0633 (0.9); 8.0596 (0.9); 8.0428 (1.0); 8.0392 (1.0); 7.7380 (3.7); 7.2948 (1.0); 7.2832 (1.0); 7.2744 (1.0); 7.2611 (13.5); 5.2987 (1.8); 4.1197 (3.4); 4.1054 (3.3); 1.9246 (0.7); 1.8959 (16.0); -0.0002 (4.8)

1.35- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.35-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.8221 (0.6); 8.8197 (0.6); 8.8089 (0.6); 8.8064 (0.6); 8.0793 (0.5); 8.0614 (0.6); 7.7004 (4.3); 7.6617 (0.6); 7.6483 (0.6); 7.6420 (0.6); 7.6286 (0.6); 7.2599 (47.9); 2.6572 (0.6); 2.6490 (0.6); 2.5099 (6.0); 1.8514 (16.0); 1.2554 (0.5); 0.6896 (0.8); 0.6855 (1.3); 0.6826 (0.6); 0.6718 (1.2); 0.6675 (1.0); 0.6646 (0.5); 0.4590 (0.8); 0.4560 (0.9);δ = 8.8221 (0.6); 8.8197 (0.6); 8.8089 (0.6); 8.8064 (0.6); 8.0793 (0.5); 8.0614 (0.6); 7.7004 (4.3); 7.6617 (0.6); 7.6483 (0.6); 7.6420 (0.6); 7.6286 (0.6); 7.2599 (47.9); 2.6572 (0.6); 2.6490 (0.6); 2.5099 (6.0); 1.8514 (16.0); 1.2554 (0.5); 0.6896 (0.8); 0.6855 (1.3); 0.6826 (0.6); 0.6718 (1.2); 0.6675 (1.0); 0.6646 (0.5); 0.4590 (0.8); 0.4560 (0.9);

0.4505 (0.9); 0.4463 (0.9); 0.4423 (0.8); -0.0002 (10.2) 0.4505 (0.9); 0.4463 (0.9); 0.4423 (0.8); -0.0002 (10.2)

I.35-3: 1 H-NMR(400.0 MHz, CDCI3):  I.35-3: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.7742 (0.6); 8.7629 (0.6); 8.1702 (0.6); 8.1504 (0.6); 7.7367 (0.7); 7.7229 (1.0); 7.7170 (1.0); 7.7028 (0.8); 7.6986 (4.9); 7.5183 (0.7); 7.2954 (0.5); 7.2916 (0.5); 7.2771 (0.8); 7.2731 (0.9); 7.2724 (0.9); 7.2715 (0.9); 7.2700δ = 8.7742 (0.6); 8.7629 (0.6); 8.1702 (0.6); 8.1504 (0.6); 7.7367 (0.7); 7.7229 (1.0); 7.7170 (1.0); 7.7028 (0.8); 7.6986 (4.9); 7.5183 (0.7); 7.2954 (0.5); 7.2916 (0.5); 7.2771 (0.8); 7.2731 (0.9); 7.2724 (0.9); 7.2715 (0.9); 7.2700

(1.0) ; 7.2691 (1.0); 7.2683 (1.1); 7.2675 (1.2); 7.2659 (1.5); 7.2594 (122.2); 7.2259 (0.6); 6.9954 (0.7); 2.5393 (5.9); 1.8589 (16.0); 1.4552 (0.8); 1.4406 (1.4); 1.4337 (1.6); 1.4306 (1.0); 1.4194 (1.0); 1.2562 (2.2); 1.2061 (0.9); 1.1915(1.0); 7.2691 (1.0); 7.2683 (1.1); 7.2675 (1.2); 7.2659 (1.5); 7.2594 (122.2); 7.2259 (0.6); 6.9954 (0.7); 2.5393 (5.9); 1.8589 (16.0); 1.4552 (0.8); 1.4406 (1.4); 1.4337 (1.6); 1.4306 (1.0); 1.4194 (1.0); 1.2562 (2.2); 1.2061 (0.9); 1.1915

(1.4) ; 1.1851 (1.4); 1.1701 (0.6); 0.0079 (1.6); 0.0063 (0.7); -0.0002 (46.4); -0.0059 (1.4); -0.0068 (1.3); -0.0085 (2.0) I.35-56: 1 H-NMR(400.0 MHz, CDCI3): (1.4); 1.1851 (1.4); 1.1701 (0.6); 0.0079 (1.6); 0.0063 (0.7); -0.0002 (46.4); -0.0059 (1.4); -0.0068 (1.3); -0.0085 (2.0) I.35-56: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7586 (0.7); 8.7473 (0.7); 8.2191 (0.7); 8.1992 (0.8); 7.7784 (0.8); 7.7645 (0.8); 7.7585 (0.8); 7.7446 (0.8); 7.7095 (4.7); 7.5183 (0.6); 7.4003 (0.8); 7.2934 (0.6); 7.2594 (101.0); 6.9954 (0.6); 3.8650 (0.7); 3.8432 (0.6); 3.8336δ = 8.7586 (0.7); 8.7473 (0.7); 8.2191 (0.7); 8.1992 (0.8); 7.7784 (0.8); 7.7645 (0.8); 7.7585 (0.8); 7.7446 (0.8); 7.7095 (4.7); 7.5183 (0.6); 7,4003 (0.8); 7.2934 (0.6); 7.2594 (101.0); 6.9954 (0.6); 3.8650 (0.7); 3.8432 (0.6); 3.8336

(1.1) ; 3.8237 (0.5); 3.7410 (0.8); 3.7355 (0.8); 3.7148 (0.9); 3.7094 (1.2); 3.6836 (0.6); 2.5602 (6.9); 2.3383 (0.7); 2.3052 (0.8); 1.9545 (0.5); 1.9444 (0.5); 1.9283 (0.6); 1.9192 (0.8); 1.9096 (0.6); 1.8940 (0.6); 1.8839 (0.7); 1.8592(1.1); 3.8237 (0.5); 3.7410 (0.8); 3.7355 (0.8); 3.7148 (0.9); 3.7094 (1.2); 3.6836 (0.6); 2.5602 (6.9); 2.3383 (0.7); 2.3052 (0.8); 1.9545 (0.5); 1.9444 (0.5); 1.9283 (0.6); 1.9192 (0.8); 1.9096 (0.6); 1.8940 (0.6); 1.8839 (0.7); 1.8592

(16.0); 1.2559 (1.6); 0.0080 (1.6); -0.0002 (38.5); -0.0085 (1.4) (16.0); 1.2559 (1.6); 0.0080 (1.6); -0.0002 (38.5); -0.0085 (1.4)

1.35-124: 1 H-NMR(400.0 MHz, CDCI3):  1.35-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5815 (0.5); 8.5788 (0.6); 8.5697 (0.6); 8.5670 (0.6); 7.5903 (0.6); 7.5884 (0.6); 7.5387 (3.8); 7.2613 (15.5); 7.2403 (0.6); 7.2284 (0.6); 7.2210 (0.6); 7.2091 (0.5); 5.2982 (0.5); 2.3693 (5.9); 1.8264 (16.0); 1.5724 (1.0); 1.5420δ = 8.5815 (0.5); 8.5788 (0.6); 8.5697 (0.6); 8.5670 (0.6); 7.5903 (0.6); 7.5884 (0.6); 7.5387 (3.8); 7.2613 (15.5); 7.2403 (0.6); 7.2284 (0.6); 7.2210 (0.6); 7.2091 (0.5); 5.2982 (0.5); 2.3693 (5.9); 1.8264 (16.0); 1.5724 (1.0); 1.5420

(0.7); -0.0002 (5.6) (0.7); -0.0002 (5.6)

1.35-136: 1 H-NMR(400.0 MHz, CDCI3):  1.35-136: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5096 (0.7); 8.5066 (0.8); 8.4980 (0.8); 8.4949 (0.8); 7.5754 (0.7); 7.5567 (0.7); 7.5193 (2.5); 7.5132 (2.5); 7.2612 (24.3); 7.1615 (0.8); 7.1496 (0.8); 7.1424 (0.7); 7.1305 (0.7); 6.9836 (1.3); 6.9778 (1.3); 5.2984 (0.6); 2.7265δ = 8.5096 (0.7); 8.5066 (0.8); 8.4980 (0.8); 8.4949 (0.8); 7.5754 (0.7); 7.5567 (0.7); 7.5193 (2.5); 7.5132 (2.5); 7.2612 (24.3); 7.1615 (0.8); 7.1496 (0.8); 7.1424 (0.7); 7.1305 (0.7); 6.9836 (1.3); 6.9778 (1.3); 5.2984 (0.6); 2.7265

(0.6); 2.6154 (8.3); 1.8544 (16.0); 1.5890 (0.7); -0.0002 (9.8) (0.6); 2.6154 (8.3); 1.8544 (16.0); 1.5890 (0.7); -0.0002 (9.8)

1.35-152: 1 H-NMR(400.0 MHz, CDCI3):  1.35-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.0355 (0.6); 9.0329 (0.6); 9.0217 (0.6); 9.0192 (0.6); 8.1431 (0.5); 8.1410 (0.6); 8.1233 (0.6); 8.1213 (0.6); 7.7391 (0.7); 7.7254 (0.7); 7.7193 (0.7); 7.7056 (0.6); 7.6431 (4.9); 7.5184 (0.5); 7.2596 (99.3); 6.9956 (0.5); 2.5121δ = 9.0355 (0.6); 9.0329 (0.6); 9.0217 (0.6); 9.0192 (0.6); 8.1431 (0.5); 8.1410 (0.6); 8.1233 (0.6); 8.1213 (0.6); 7.7391 (0.7); 7.7254 (0.7); 7.7193 (0.7); 7.7056 (0.6); 7.6431 (4.9); 7.5184 (0.5); 7.2596 (99.3); 6.9956 (0.5); 2.5121

(5.8) ; 1.8518 (16.0); 1.2560 (0.6); 0.0079 (0.9); -0.0002 (29.6); -0.0085 (1.1) (5.8); 1.8518 (16.0); 1.2560 (0.6); 0.0079 (0.9); -0.0002 (29.6); -0.0085 (1.1)

1.35-167: 1 H-NMR(400.0 MHz, CDCI3):  1.35-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9900 (0.6); 8.9785 (0.6); 8.1965 (0.6); 8.1784 (0.6); 7.7823 (0.7); 7.7683 (0.7); 7.7625 (0.6); 7.7485 (0.6); 7.6468 (3.8); 7.2595 (83.3); 3.0206 (0.7); 2.9353 (0.5); 2.5230 (6.2); 2.1130 (0.8); 1.8540 (16.0); 1.2565 (1.2); 0.0080δ = 8.9900 (0.6); 8.9785 (0.6); 8.1965 (0.6); 8.1784 (0.6); 7.7823 (0.7); 7.7683 (0.7); 7.7625 (0.6); 7.7485 (0.6); 7.6468 (3.8); 7.2595 (83.3); 3.0206 (0.7); 2.9353 (0.5); 2.5230 (6.2); 2.1130 (0.8); 1.8540 (16.0); 1.2565 (1.2); 0.0080

(0.9); -0.0002 (25.0); -0.0085 (0.8) (0.9); -0.0002 (25.0); -0.0085 (0.8)

1.35-213: 1 H-NMR(400.0 MHz, CDCI3):  1.35-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.8830 (0.6); 8.8807 (0.7); 8.8692 (0.7); 8.8668 (0.7); 8.2514 (0.6); 8.2496 (0.6); 8.2316 (0.7); 8.2297 (0.7); 7.8111 (0.8); 7.7972 (0.8); 7.7913 (0.8); 7.7832 (4.6); 7.7774 (0.8); 7.2640 (9.0); 5.2996 (3.6); 4.0790 (2.9); 4.0649δ = 8.8830 (0.6); 8.8807 (0.7); 8.8692 (0.7); 8.8668 (0.7); 8.2514 (0.6); 8.2496 (0.6); 8.2316 (0.7); 8.2297 (0.7); 7.8111 (0.8); 7.7972 (0.8); 7.7913 (0.8); 7.7832 (4.6); 7.7774 (0.8); 7.2640 (9.0); 5.2996 (3.6); 4.0790 (2.9); 4.0649

(2.9) ; 2.5659 (6.5); 1.9079 (16.0); -0.0002 (3.5) 1.35-227: 1 H-NMR(400.0 MHz, CDCI3): (2.9); 2.5659 (6.5); 1.9079 (16.0); -0.0002 (3.5) 1.35-227: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5806 (0.5); 8.5793 (0.6); 8.5766 (0.6); 8.5752 (0.6); 8.5687 (0.6); 8.5674 (0.6); 8.5647 (0.6); 8.5635 (0.5); 7.7250 (4.4); 7.6479 (0.5); 7.6462 (0.6); 7.6439 (0.6); 7.6286 (0.6); 7.6268 (0.7); 7.6245 (0.6); 7.6228 (0.5); 7.2835 (0.7); 7.2713 (0.8); 7.2622 (11.9); 7.2524 (0.8); 5.2983 (1.5); 3.4510 (0.7); 3.4345 (1.8); 3.4190 (1.9); 3.4026 (0.8); 2.5927 (1.6); 2.5761 (3.3); 2.5595 (1.5); 2.3993 (6.1); 2.0430 (1.0); 1.8867 (16.0); 1.2581 (1.0); 1.2548 (0.6); -0.0002δ = 8.5806 (0.5); 8.5793 (0.6); 8.5766 (0.6); 8.5752 (0.6); 8.5687 (0.6); 8.5674 (0.6); 8.5647 (0.6); 8.5635 (0.5); 7.7250 (4.4); 7.6479 (0.5); 7.6462 (0.6); 7.6439 (0.6); 7.6286 (0.6); 7.6268 (0.7); 7.6245 (0.6); 7.6228 (0.5); 7.2835 (0.7); 7.2713 (0.8); 7.2622 (11.9); 7.2524 (0.8); 5.2983 (1.5); 3.4510 (0.7); 3.4345 (1.8); 3.4190 (1.9); 3.4026 (0.8); 2.5927 (1.6); 2.5761 (3.3); 2.5595 (1.5); 2.3993 (6.1); 2.0430 (1.0); 1.8867 (16.0); 1.2581 (1.0); 1.2548 (0.6); -0.0002

(4-5) (4-5)

I.35-228: 1 H-NMR(400.0 MHz, CDCI3):  I.35-228: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7501 (0.6); 8.7376 (0.6); 7.6551 (3.5); 7.5183 (0.6); 7.2594 (109.6); 6.9954 (0.6); 3.6007 (0.6); 2.6947 (1.6); 2.4093 (6.0); 1.8573 (16.0); 1.2559 (3.8); 0.8802 (0.8); 0.8746 (0.6); 0.8532 (0.8); 0.8370 (0.6); 0.0079 (1.3); -0.0002δ = 8.7501 (0.6); 8.7376 (0.6); 7.6551 (3.5); 7.5183 (0.6); 7.2594 (109.6); 6.9954 (0.6); 3.6007 (0.6); 2.6947 (1.6); 2.4093 (6.0); 1.8573 (16.0); 1.2559 (3.8); 0.8802 (0.8); 0.8746 (0.6); 0.8532 (0.8); 0.8370 (0.6); 0.0079 (1.3); -0.0002

(41.6) (41.6)

1.39-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.39-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6687 (3.5); 7.4028 (1.6); 7.3894 (1.8); 7.2598 (37.6); 7.0585 (1.7); 7.0452 (1.7); 2.6793 (0.6); 2.6699 (0.6); 1.8438 (16.0); 1.5412 (15.1); 0.7359 (1.0); 0.7329 (1.3); 0.7189 (1.4); 0.7150 (1.1); 0.4258 (1.0); 0.4221 (1.1); 0.4161δ = 7.6687 (3.5); 7.4028 (1.6); 7.3894 (1.8); 7.2598 (37.6); 7.0585 (1.7); 7.0452 (1.7); 2.6793 (0.6); 2.6699 (0.6); 1.8438 (16.0); 1.5412 (15.1); 0.7359 (1.0); 0.7329 (1.3); 0.7189 (1.4); 0.7150 (1.1); 0.4258 (1.0); 0.4221 (1.1); 0.4161

(1.0); 0.4124 (1.0); -0.0002 (13.9); -0.0012 (10.8); -0.0083 (0.7) (1.0); 0.4124 (1.0); -0.0002 (13.9); -0.0012 (10.8); -0.0083 (0.7)

1.39-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.39-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5814 (3.9); 7.3702 (1.8); 7.3568 (2.0); 7.2601 (31.5); 7.0266 (2.0); 7.0131 (1.8); 5.2986 (1.0); 3.5320 (0.8); 2.6670 (0.8); 1.8299 (16.0); 1.7564 (1.0); 1.7498 (1.1); 1.7444 (1.1); 1.7397 (1.0); 1.5474 (10.4); -0.0002 (12.3) 1.39-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5814 (3.9); 7.3702 (1.8); 7.3568 (2.0); 7.2601 (31.5); 7.0266 (2.0); 7.0131 (1.8); 5.2986 (1.0); 3.5320 (0.8); 2.6670 (0.8); 1.8299 (16.0); 1.7564 (1.0); 1.7498 (1.1); 1.7444 (1.1); 1.7397 (1.0); 1.5474 (10.4); -0.0002 (12.3) 1.39-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5680 (2.6); 7.5652 (3.0); 7.3860 (1.2); 7.3831 (1.4); 7.3727 (1.4); 7.3697 (1.5); 7.2627 (28.0); 7.2598 (33.3); 7.2557 (12.9); 7.0377 (1.3); 7.0348 (1.5); 7.0244 (1.3); 7.0215 (1.4); 5.2985 (0.6); 3.5172 (0.8); 1.8388 (16.0); 1.5425δ = 7.5680 (2.6); 7.5652 (3.0); 7.3860 (1.2); 7.3831 (1.4); 7.3727 (1.4); 7.3697 (1.5); 7.2627 (28.0); 7.2598 (33.3); 7.2557 (12.9); 7.0377 (1.3); 7.0348 (1.5); 7.0244 (1.3); 7.0215 (1.4); 5.2985 (0.6); 3.5172 (0.8); 1.8388 (16.0); 1.5425

(10.3); 1.5396 (12.1); 0.0027 (10.5); -0.0002 (12.5); -0.0047 (5.1) (10.3); 1.5396 (12.1); 0.0027 (10.5); -0.0002 (12.5); -0.0047 (5.1)

I.39-353: 1 H-NMR(400.0 MHz, CDCI3):  I.39-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.7691 (0.7); 7.6878 (3.9); 7.4236 (1.8); 7.4102 (2.0); 7.2605 (49.0); 7.0744 (2.0); 7.0611 (1.9); 4.4331 (0.5); 4.4238 (0.6); 4.1304 (0.5); 4.1126 (0.5); 3.9564 (0.9); 3.9508 (0.7); 3.9486 (0.8); 3.9300 (1.4); 3.9256 (0.7); 3.9192 (1.5); 3.9156 (1.0); 3.9118 (0.7); 3.9079 (1.6); 3.6632 (0.8); 3.6525 (0.9); 3.6420 (0.7); 2.0437 (2.5); 1.8960 (16.0); 1.5574 (2.2); 1.2765 (0.8); 1.2587 (1.6); 1.2408 (0.7); 1.1095 (1.0); 1.1061 (1.0); 1.0911 (1.9); 1.0877 (1.9); 1.0727δ = 9.7691 (0.7); 7.6878 (3.9); 7.4236 (1.8); 7.4102 (2.0); 7.2605 (49.0); 7.0744 (2.0); 7.0611 (1.9); 4.4331 (0.5); 4.4238 (0.6); 4.1304 (0.5); 4.1126 (0.5); 3.9564 (0.9); 3.9508 (0.7); 3.9486 (0.8); 3.9300 (1.4); 3.9256 (0.7); 3.9192 (1.5); 3.9156 (1.0); 3.9118 (0.7); 3.9079 (1.6); 3.6632 (0.8); 3.6525 (0.9); 3.6420 (0.7); 2.0437 (2.5); 1.8960 (16.0); 1.5574 (2.2); 1.2765 (0.8); 1.2587 (1.6); 1.2408 (0.7); 1.1095 (1.0); 1.1061 (1.0); 1.0911 (1.9); 1.0877 (1.9); 1.0727

(0.9); 1.0692 (0.8); 0.8818 (0.6); 0.0080 (0.6); -0.0002 (18.8); -0.0085 (0.7) (0.9); 1.0692 (0.8); 0.8818 (0.6); 0.0080 (0.6); -0.0002 (18.8); -0.0085 (0.7)

I.43-2: 1 H-NMR(400.0 MHz, CDCI3):  I.43-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7262 (4.2); 7.4114 (0.8); 7.2601 (30.6); 7.0470 (1.1); 7.0285 (1.2); 7.0260 (1.1); 7.0075 (1.0); 1.8537 (0.5); 1.8338 (16.0); 1.5456 (8.3); 1.3162 (6.3); 0.6264 (1.2); 0.6171 (1.2); 0.5902 (1.4); 0.5844 (1.1); 0.5823 (1.3); 0.5800δ = 7.7262 (4.2); 7.4114 (0.8); 7.2601 (30.6); 7.0470 (1.1); 7.0285 (1.2); 7.0260 (1.1); 7.0075 (1.0); 1.8537 (0.5); 1.8338 (16.0); 1.5456 (8.3); 1.3162 (6.3); 0.6264 (1.2); 0.6171 (1.2); 0.5902 (1.4); 0.5844 (1.1); 0.5823 (1.3); 0.5800

(1.3); -0.0002 (11.4) (1.3); -0.0002 (11.4)

1.43-102: 1 H-NMR(400.0 MHz, CDCI3):  1.43-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6375 (8.0); 7.5190 (0.5); 7.4090 (0.5); 7.3932 (1.1); 7.3879 (0.9); 7.3773 (0.7); 7.3721 (2.2); 7.3668 (0.8); 7.3562 (1.0); 7.3510 (1.3); 7.3351 (0.6); 7.2602 (87.1); 7.0007 (3.0); 6.9962 (1.0); 6.9928 (0.5); 6.9892 (0.6); 6.9824 (3.3); 6.9796 (3.1); 6.9733 (0.7); 6.9614 (2.6); 5.2984 (0.8); 4.2876 (0.6); 4.2793 (0.7); 4.2713 (0.8); 4.2634 (0.6); 4.2537 (0.5); 2.6654 (1.8); 2.6478 (2.9); 2.6328 (1.2); 1.8801 (0.8); 1.8686 (0.8); 1.8628 (1.1); 1.8458 (2.1); 1.8264 (16.0); 1.8184 (13.5); 1.6902 (0.9); 1.6755 (0.8); 1.6613 (0.8); 1.5508 (8.1); 1.4642 (0.7); 1.4509 (0.7); 1.4416 (0.7);δ = 7.6375 (8.0); 7.5190 (0.5); 7.4090 (0.5); 7.3932 (1.1); 7.3879 (0.9); 7.3773 (0.7); 7.3721 (2.2); 7.3668 (0.8); 7.3562 (1.0); 7.3510 (1.3); 7.3351 (0.6); 7.2602 (87.1); 7,0007 (3.0); 6.9962 (1.0); 6.9928 (0.5); 6.9892 (0.6); 6.9824 (3.3); 6.9796 (3.1); 6.9733 (0.7); 6.9614 (2.6); 5.2984 (0.8); 4.2876 (0.6); 4.2793 (0.7); 4.2713 (0.8); 4.2634 (0.6); 4.2537 (0.5); 2.6654 (1.8); 2.6478 (2.9); 2.6328 (1.2); 1.8801 (0.8); 1.8686 (0.8); 1.8628 (1.1); 1.8458 (2.1); 1.8264 (16.0); 1.8184 (13.5); 1.6902 (0.9); 1.6755 (0.8); 1.6613 (0.8); 1.5508 (8.1); 1.4642 (0.7); 1.4509 (0.7); 1.4416 (0.7);

1.4376 (0.6); 1.4280 (0.7); 1.2114 (7.9); 1.1957 (7.9); 0.0079 (1.0); -0.0002 (34.2); -0.0085 (1.2) 1.4376 (0.6); 1.4280 (0.7); 1.2114 (7.9); 1.1957 (7.9); 0.0079 (1.0); -0.0002 (34.2); -0.0085 (1.2)

1.43-124: 1 H-NMR(400.0 MHz, CDCI3):  1.43-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6039 (4.3); 7.3749 (0.8); 7.2600 (28.8); 7.2544 (0.8); 7.0045 (1.0); 6.9862 (1.2); 6.9835 (1.0); 6.9653 (0.9);δ = 7.6039 (4.3); 7.3749 (0.8); 7.2600 (28.8); 7.2544 (0.8); 7.0045 (1.0); 6.9862 (1.2); 6.9835 (1.0); 6.9653 (0.9);

1.8387 (16.0); 1.5447 (7.9); -0.0002 (11.7) 1.8387 (16.0); 1.5447 (7.9); -0.0002 (11.7)

1.43-136: 1 H-NMR(400.0 MHz, CDCI3):  1.43-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6333 (4.2); 7.4151 (0.5); 7.4098 (0.5); 7.3940 (1.0); 7.3779 (0.6); 7.3730 (0.6); 7.2603 (24.5); 7.0170 (1.5); 6.9964 (2.2); 6.9778 (1.4); 5.2985 (1.6); 2.7964 (0.5); 2.7855 (0.8); 2.7744 (0.6); 2.0434 (0.6); 1.8646 (0.8); 1.8453δ = 7.6333 (4.2); 7.4151 (0.5); 7.4098 (0.5); 7.3940 (1.0); 7.3779 (0.6); 7.3730 (0.6); 7.2603 (24.5); 7.0170 (1.5); 6.9964 (2.2); 6.9778 (1.4); 5.2985 (1.6); 2.7964 (0.5); 2.7855 (0.8); 2.7744 (0.6); 2.0434 (0.6); 1.8646 (0.8); 1.8453

(16.0); 1.6802 (0.8); 1.6634 (0.8); 1.5445 (9.6); -0.0002 (9.4) (16.0); 1.6802 (0.8); 1.6634 (0.8); 1.5445 (9.6); -0.0002 (9.4)

1.43-152: 1 H-NMR(400.0 MHz, CDCI3):  1.43-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6429 (3.9); 7.3888 (0.8); 7.2601 (21.1); 7.0124 (1.1); 6.9942 (1.2); 6.9914 (1.2); 6.9732 (1.0); 5.2983 (0.7);δ = 7.6429 (3.9); 7.3888 (0.8); 7.2601 (21.1); 7.0124 (1.1); 6.9942 (1.2); 6.9914 (1.2); 6.9732 (1.0); 5.2983 (0.7);

1.8512 (16.0); 1.5489 (1.0); -0.0002 (8.1) 1.8512 (16.0); 1.5489 (1.0); -0.0002 (8.1)

1.43-192: 1 H-NMR(400.0 MHz, CDCI3):  1.43-192: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5325 (1.9); 7.5306 (1.9); 7.3686 (0.8); 7.3475 (0.5); 7.2605 (27.9); 7.0324 (1.1); 7.0129 (1.4); 6.9923 (1.2); 5.2986 (0.6); 5.0637 (0.8); 3.7218 (0.6); 3.7067 (1.2); 3.6918 (1.4); 3.6764 (0.7); 3.2760 (1.4); 3.2644 (1.1); 3.2608 (1.5); 3.2584 (1.2); 3.2461 (1.2); 2.1736 (2.9); 2.1287 (0.5); 2.0293 (4.9); 2.0274 (5.0); 1.8559 (16.0); -0.0002 (9.8) I.43-303: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5325 (1.9); 7.5306 (1.9); 7.3686 (0.8); 7.3475 (0.5); 7.2605 (27.9); 7.0324 (1.1); 7.0129 (1.4); 6.9923 (1.2); 5.2986 (0.6); 5.0637 (0.8); 3.7218 (0.6); 3.7067 (1.2); 3.6918 (1.4); 3.6764 (0.7); 3.2760 (1.4); 3.2644 (1.1); 3.2608 (1.5); 3.2584 (1.2); 3.2461 (1.2); 2.1736 (2.9); 2.1287 (0.5); 2.0293 (4.9); 2.0274 (5.0); 1.8559 (16.0); -0.0002 (9.8) I.43-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6937 (4.0); 7.3608 (0.8); 7.2599 (33.2); 6.9872 (1.1); 6.9688 (1.2); 6.9661 (1.1); 6.9479 (1.0); 3.1750 (9.5);δ = 7.6937 (4.0); 7.3608 (0.8); 7.2599 (33.2); 6.9872 (1.1); 6.9688 (1.2); 6.9661 (1.1); 6.9479 (1.0); 3.1750 (9.5);

3.1635 (0.6); 3.0485 (6.8); 1.8635 (0.7); 1.8440 (16.0); 1.5428 (7.9); -0.0002 (11.7); -0.0085 (0.6) 3.1635 (0.6); 3.0485 (6.8); 1.8635 (0.7); 1.8440 (16.0); 1.5428 (7.9); -0.0002 (11.7); -0.0085 (0.6)

I.43-353: 1 H-NMR(400.0 MHz, CDCI3):  I.43-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3389 (0.7); 7.7580 (3.7); 7.4288 (0.8); 7.2598 (44.8); 7.0572 (1.2); 7.0386 (1.4); 7.0363 (1.3); 7.0175 (1.1); 3.9183 (1.1); 3.9138 (0.5); 3.9076 (1.2); 3.9041 (0.9); 3.8963 (1.3); 3.6537 (1.1); 3.6425 (1.1); 3.6316 (0.9); 2.6674δ = 9.3389 (0.7); 7.7580 (3.7); 7.4288 (0.8); 7.2598 (44.8); 7.0572 (1.2); 7.0386 (1.4); 7.0363 (1.3); 7.0175 (1.1); 3.9183 (1.1); 3.9138 (0.5); 3.9076 (1.2); 3.9041 (0.9); 3.8963 (1.3); 3.6537 (1.1); 3.6425 (1.1); 3.6316 (0.9); 2.6674

(1.0); 1.9242 (0.6); 1.9101 (16.0); 0.0080 (0.5); -0.0002 (17.2); -0.0085 (0.6) (1.0); 1.9242 (0.6); 1.9101 (16.0); 0.0080 (0.5); -0.0002 (17.2); -0.0085 (0.6)

1.46-167: 1 H-NMR(400.0 MHz, CDCI3):  1.46-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6451 (0.9); 8.6413 (0.9); 8.6334 (0.9); 8.6297 (0.9); 7.8305 (1.0); 7.8267 (0.9); 7.8101 (1.0); 7.8063 (1.0); 7.5923 (3.9); 7.3266 (1.0); 7.3150 (1.0); 7.3063 (1.0); 7.2945 (1.0); 7.2617 (15.9); 2.9551 (1.3); 2.8840 (1.0); 2.8826 (1.0); 1.8552 (16.0); 1.5701 (2.1); -0.0002 (6.0) 1.46- 353: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6451 (0.9); 8.6413 (0.9); 8.6334 (0.9); 8.6297 (0.9); 7.8305 (1.0); 7.8267 (0.9); 7.8101 (1.0); 7.8063 (1.0); 7.5923 (3.9); 7.3266 (1.0); 7.3150 (1.0); 7.3063 (1.0); 7.2945 (1.0); 7.2617 (15.9); 2.9551 (1.3); 2.8840 (1.0); 2.8826 (1.0); 1.8552 (16.0); 1.5701 (2.1); -0.0002 (6.0) 1.46-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.5853 (0.7); 8.5685 (0.5); 8.5648 (0.9); 8.5612 (0.5); 8.5569 (0.6); 8.5532 (0.9); 8.5496 (0.5); 7.7581 (4.1); 7.5825 (0.7); 7.5794 (1.0); 7.5763 (0.5); 7.5586 (0.6); 7.5552 (0.6); 7.4455 (0.6); 7.4352 (0.7); 7.4340 (0.7); 7.4240 (0.9); 7.4142 (0.5); 7.4129 (0.6); 7.2619 (18.4); 3.9412 (1.2); 3.9331 (0.8); 3.9303 (1.3); 3.9264 (0.8); 3.9236 (0.5); 3.9189 (1.4); 3.7148 (1.2); 3.7074 (0.7); 3.7035 (1.1); 3.6926 (0.9); 1.9124 (16.0); -0.0002 (9.4) δ = 9.5853 (0.7); 8.5685 (0.5); 8.5648 (0.9); 8.5612 (0.5); 8.5569 (0.6); 8.5532 (0.9); 8.5496 (0.5); 7.7581 (4.1); 7.5825 (0.7); 7.5794 (1.0); 7.5763 (0.5); 7.5586 (0.6); 7.5552 (0.6); 7.4455 (0.6); 7.4352 (0.7); 7.4340 (0.7); 7.4240 (0.9); 7.4142 (0.5); 7.4129 (0.6); 7.2619 (18.4); 3.9412 (1.2); 3.9331 (0.8); 3.9303 (1.3); 3.9264 (0.8); 3.9236 (0.5); 3.9189 (1.4); 3.7148 (1.2); 3.7074 (0.7); 3.7035 (1.1); 3.6926 (0.9); 1.9124 (16.0); -0.0002 (9.4)

1.47- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.47-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.6598 (0.9); 8.6561 (1.0); 8.6481 (1.0); 8.6444 (1.0); 7.8603 (1.0); 7.8565 (1.0); 7.8398 (1.1); 7.8361 (1.1); 7.7312 (4.2); 7.3546 (1.2); 7.3430 (1.1); 7.3342 (1.1); 7.3225 (1.0); 7.2612 (17.5); 2.6641 (0.6); 2.6557 (0.6); 1.8618 (16.0); 1.5730 (0.8); 0.7265 (0.6); 0.7246 (0.9); 0.7212 (1.3); 0.7184 (0.6); 0.7083 (0.9); 0.7069 (1.2); 0.7033 (1.0);δ = 8.6598 (0.9); 8.6561 (1.0); 8.6481 (1.0); 8.6444 (1.0); 7.8603 (1.0); 7.8565 (1.0); 7.8398 (1.1); 7.8361 (1.1); 7.7312 (4.2); 7.3546 (1.2); 7.3430 (1.1); 7.3342 (1.1); 7.3225 (1.0); 7.2612 (17.5); 2.6641 (0.6); 2.6557 (0.6); 1.8618 (16.0); 1.5730 (0.8); 0.7265 (0.6); 0.7246 (0.9); 0.7212 (1.3); 0.7184 (0.6); 0.7083 (0.9); 0.7069 (1.2); 0.7033 (1.0);

0.7004 (0.5); 0.4048 (0.8); 0.4018 (1.0); 0.3984 (0.9); 0.3958 (0.8); 0.3921 (0.9); 0.3887 (0.9); -0.0002 (6.7) 0.7004 (0.5); 0.4048 (0.8); 0.4018 (1.0); 0.3984 (0.9); 0.3958 (0.8); 0.3921 (0.9); 0.3887 (0.9); -0.0002 (6.7)

I.47-2: 1 H-NMR(400.0 MHz, CDCI3):  I.47-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6633 (0.9); 8.6597 (0.9); 8.6517 (1.0); 8.6480 (0.9); 7.8648 (1.0); 7.8611 (1.0); 7.8444 (1.0); 7.8407 (1.0); 7.7178 (3.9); 7.3554 (1.0); 7.3437 (1.0); 7.3350 (1.0); 7.3233 (1.0); 7.2606 (24.2); 1.8372 (16.0); 1.5569 (6.3); 1.3003δ = 8.6633 (0.9); 8.6597 (0.9); 8.6517 (1.0); 8.6480 (0.9); 7.8648 (1.0); 7.8611 (1.0); 7.8444 (1.0); 7.8407 (1.0); 7.7178 (3.9); 7.3554 (1.0); 7.3437 (1.0); 7.3350 (1.0); 7.3233 (1.0); 7.2606 (24.2); 1.8372 (16.0); 1.5569 (6.3); 1.3003

(6.6); 0.6189 (1.3); 0.6103 (1.3); 0.5841 (1.4); 0.5766 (1.3); 0.5742 (1.4); -0.0002 (9.2) (6.6); 0.6189 (1.3); 0.6103 (1.3); 0.5841 (1.4); 0.5766 (1.3); 0.5742 (1.4); -0.0002 (9.2)

1.47-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.47-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6425 (1.0); 8.6388 (1.0); 8.6309 (1.0); 8.6271 (1.0); 7.8273 (1.0); 7.8236 (1.0); 7.8070 (1.1); 7.8032 (1.1); 7.6378 (4.2); 7.3245 (1.1); 7.3128 (1.1); 7.3041 (1.0); 7.2924 (1.0); 7.2614 (22.5); 5.2984 (3.8); 3.5328 (0.8); 2.7125δ = 8.6425 (1.0); 8.6388 (1.0); 8.6309 (1.0); 8.6271 (1.0); 7.8273 (1.0); 7.8236 (1.0); 7.8070 (1.1); 7.8032 (1.1); 7.6378 (4.2); 7.3245 (1.1); 7.3128 (1.1); 7.3041 (1.0); 7.2924 (1.0); 7.2614 (22.5); 5.2984 (3.8); 3.5328 (0.8); 2.7125

(0.8); 1.8489 (16.0); 1.7543 (0.8); 1.7444 (1.0); 1.7387 (1.0); 1.7290 (0.7); -0.0002 (8.2) (0.8); 1.8489 (16.0); 1.7543 (0.8); 1.7444 (1.0); 1.7387 (1.0); 1.7290 (0.7); -0.0002 (8.2)

1.47-152: 1 H-NMR(400.0 MHz, CDCI3):  1.47-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6480 (1.0); 8.6443 (1.0); 8.6363 (1.0); 8.6326 (1.0); 7.8374 (1.0); 7.8337 (1.0); 7.8170 (1.1); 7.8133 (1.1); 7.6138 (4.1); 7.3411 (1.1); 7.3294 (1.1); 7.3207 (1.0); 7.3090 (1.0); 7.2611 (18.4); 5.2985 (2.2); 1.8589 (16.0); 1.5583δ = 8.6480 (1.0); 8.6443 (1.0); 8.6363 (1.0); 8.6326 (1.0); 7.8374 (1.0); 7.8337 (1.0); 7.8170 (1.1); 7.8133 (1.1); 7.6138 (4.1); 7.3411 (1.1); 7.3294 (1.1); 7.3207 (1.0); 7.3090 (1.0); 7.2611 (18.4); 5.2985 (2.2); 1.8589 (16.0); 1.5583

(4.2); -0.0002 (7.3) (4.2); -0.0002 (7.3)

1.47-167: 1 H-NMR(400.0 MHz, CDCI3):  1.47-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5742 (0.7); 8.5626 (0.8); 7.6000 (3.6); 7.5197 (0.7); 7.5167 (0.8); 7.4961 (0.5); 7.4926 (0.5); 7.3838 (0.5);δ = 8.5742 (0.7); 8.5626 (0.8); 7.6000 (3.6); 7.5197 (0.7); 7.5167 (0.8); 7.4961 (0.5); 7.4926 (0.5); 7.3838 (0.5);

7.3738 (0.6); 7.3723 (0.6); 7.3625 (0.8); 7.2605 (25.2); 5.2985 (0.6); 1.8608 (16.0); -0.0002 (9.5) 7.3738 (0.6); 7.3723 (0.6); 7.3625 (0.8); 7.2605 (25.2); 5.2985 (0.6); 1.8608 (16.0); -0.0002 (9.5)

1.47-167: 1 H-NMR(400.0 MHz, CDCI3):  1.47-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5789 (0.6); 8.5673 (0.7); 7.6012 (3.1); 7.5278 (0.6); 7.3830 (0.5); 7.3717 (0.7); 7.2600 (43.5); 5.2985 (16.0);δ = 8.5789 (0.6); 8.5673 (0.7); 7.6012 (3.1); 7.5278 (0.6); 7.3830 (0.5); 7.3717 (0.7); 7.2600 (43.5); 5.2985 (16.0);

3.7216 (0.6); 2.9553 (0.5); 1.9063 (0.9); 1.8618 (13.7); 0.0079 (0.5); -0.0002 (17.9); -0.0085 (0.6) 3.7216 (0.6); 2.9553 (0.5); 1.9063 (0.9); 1.8618 (13.7); 0.0079 (0.5); -0.0002 (17.9); -0.0085 (0.6)

1.47-170: 1 H-NMR(400.0 MHz, CDCI3):  1.47-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6554 (1.0); 8.6517 (1.0); 8.6437 (1.0); 8.6400 (1.0); 7.8526 (1.0); 7.8489 (1.1); 7.8322 (1.2); 7.8285 (1.1); 7.7778 (4.4); 7.3457 (1.2); 7.3340 (1.2); 7.3253 (1.1); 7.3136 (1.1); 7.2617 (14.0); 3.9584 (2.8); 3.9444 (2.8); 3.7096δ = 8.6554 (1.0); 8.6517 (1.0); 8.6437 (1.0); 8.6400 (1.0); 7.8526 (1.0); 7.8489 (1.1); 7.8322 (1.2); 7.8285 (1.1); 7.7778 (4.4); 7.3457 (1.2); 7.3340 (1.2); 7.3253 (1.1); 7.3136 (1.1); 7.2617 (14.0); 3.9584 (2.8); 3.9444 (2.8); 3.7096

(10.5); 2.9548 (1.1); 2.8834 (0.9); 2.8821 (0.9); 1.9112 (16.0); -0.0002 (5.5) (10.5); 2.9548 (1.1); 2.8834 (0.9); 2.8821 (0.9); 1.9112 (16.0); -0.0002 (5.5)

I.47-303: 1 H-NMR(400.0 MHz, CDCI3):  I.47-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.0182 (1.5); 7.2710 (5.5); 3.1707 (0.9); 3.1083 (0.7); 2.9568 (16.0); 2.8839 (13.3); 2.8826 (13.3); 1.8629 (1.5); -δ = 8.0182 (1.5); 7.2710 (5.5); 3.1707 (0.9); 3.1083 (0.7); 2.9568 (16.0); 2.8839 (13.3); 2.8826 (13.3); 1.8629 (1.5); -

0.0002 (2.1) 0.0002 (2.1)

I.47-323: 1 H-NMR(400.0 MHz, CDCI3):  I.47-323: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7659 (0.6); 8.7578 (0.6); 8.6469 (1.0); 8.6434 (1.0); 8.6353 (1.0); 8.6317 (0.9); 7.9282 (0.5); 7.8534 (0.9); 7.8499 (0.9); 7.8330 (1.0); 7.8294 (0.9); 7.7822 (5.3); 7.3484 (0.9); 7.3367 (0.9); 7.3280 (0.8); 7.3163 (0.8); 7.2618 (20.4); 5.2986 (4.0); 4.1301 (0.5); 4.1122 (0.5); 2.0432 (2.4); 2.0017 (7.9); 1.9236 (16.0); 1.6613 (2.8); 1.2760 (0.8);δ = 8.7659 (0.6); 8.7578 (0.6); 8.6469 (1.0); 8.6434 (1.0); 8.6353 (1.0); 8.6317 (0.9); 7.9282 (0.5); 7.8534 (0.9); 7.8499 (0.9); 7.8330 (1.0); 7.8294 (0.9); 7.7822 (5.3); 7.3484 (0.9); 7.3367 (0.9); 7.3280 (0.8); 7.3163 (0.8); 7.2618 (20.4); 5.2986 (4.0); 4.1301 (0.5); 4.1122 (0.5); 2.0432 (2.4); 2.0017 (7.9); 1.9236 (16.0); 1.6613 (2.8); 1.2760 (0.8);

1.2581 (2.2); 1.2403 (0.6); -0.0002 (7.5) 1.2581 (2.2); 1.2403 (0.6); -0.0002 (7.5)

1.57-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.57-1: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7553 (4.1); 7.4142 (0.8); 7.3931 (0.5); 7.2598 (47.7); 7.0461 (1.2); 7.0277 (1.3); 7.0251 (1.2); 7.0067 (1.0); 2.7084 (0.7); 2.6988 (0.7); 1.8777 (2.6); 1.8618 (16.0); 1.5449 (14.6); 0.7265 (1.0); 0.7231 (1.4); 0.7090 (1.2); 0.7052 (1.1); 0.7025 (0.7); 0.4253 (0.5); 0.4151 (0.9); 0.4121 (1.0); 0.4086 (1.0); 0.4023 (1.0); 0.3990 (0.9); 0.0080 (0.5); -δ = 7.7553 (4.1); 7.4142 (0.8); 7.3931 (0.5); 7.2598 (47.7); 7.0461 (1.2); 7.0277 (1.3); 7.0251 (1.2); 7.0067 (1.0); 2.7084 (0.7); 2.6988 (0.7); 1.8777 (2.6); 1.8618 (16.0); 1.5449 (14.6); 0.7265 (1.0); 0.7231 (1.4); 0.7090 (1.2); 0.7052 (1.1); 0.7025 (0.7); 0.4253 (0.5); 0.4151 (0.9); 0.4121 (1.0); 0.4086 (1.0); 0.4023 (1.0); 0.3990 (0.9); 0.0080 (0.5); -

0.0002 (17.0); -0.0085 (0.6) 0.0002 (17.0); -0.0085 (0.6)

I.57-2: 1 H-NMR(400.0 MHz, CDCI3):  I.57-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7419 (3.4); 7.4143 (0.7); 7.2598 (39.2); 7.0471 (1.0); 7.0288 (1.1); 7.0261 (1.0); 7.0078 (0.9); 1.8536 (2.2); 1.8355 (12.9); 1.5442 (16.0); 1.3132 (5.6); 0.6203 (1.1); 0.6121 (1.0); 0.5854 (1.2); 0.5799 (1.0); 0.5776 (1.1); 0.5752δ = 7.7419 (3.4); 7.4143 (0.7); 7.2598 (39.2); 7.0471 (1.0); 7.0288 (1.1); 7.0261 (1.0); 7.0078 (0.9); 1.8536 (2.2); 1.8355 (12.9); 1.5442 (16.0); 1.3132 (5.6); 0.6203 (1.1); 0.6121 (1.0); 0.5854 (1.2); 0.5799 (1.0); 0.5776 (1.1); 0.5752

(1.1); -0.0002 (14.3) (1.1); -0.0002 (14.3)

1.57-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.57-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6800 (3.7); 7.3768 (0.7); 7.2600 (40.8); 7.0000 (1.0); 6.9819 (1.2); 6.9789 (1.0); 6.9610 (0.9); 3.5259 (0.8); 2.6062 (0.8); 1.8623 (2.4); 1.8392 (14.8); 1.7456 (1.0); 1.7390 (1.0); 1.7054 (0.5); 1.5494 (16.0); -0.0002 (14.7); -δ = 7.6800 (3.7); 7.3768 (0.7); 7.2600 (40.8); 7,000 (1.0); 6.9819 (1.2); 6.9789 (1.0); 6.9610 (0.9); 3.5259 (0.8); 2.6062 (0.8); 1.8623 (2.4); 1.8392 (14.8); 1.7456 (1.0); 1.7390 (1.0); 1.7054 (0.5); 1.5494 (16.0); -0.0002 (14.7); -

0.0085 (0.6) 0.0085 (0.6)

1.57-102: 1 H-NMR(400.0 MHz, CDCI3):  1.57-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6581 (4.0); 7.3961 (0.6); 7.3909 (0.5); 7.3750 (1.1); 7.3591 (0.6); 7.3539 (0.7); 7.2599 (66.4); 7.0002 (1.6); 6.9959 (0.7); 6.9820 (1.8); 6.9792 (1.7); 6.9610 (1.4); 6.9536 (0.5); 5.2982 (0.5); 2.6407 (0.6); 2.6344 (0.7); 2.6170 (1.1); 2.5999 (0.6); 1.8738 (0.5); 1.8460 (3.2); 1.8288 (8.1); 1.8185 (6.9); 1.5461 (16.0); 1.2210 (0.8); 1.2064 (4.4);δ = 7.6581 (4.0); 7.3961 (0.6); 7.3909 (0.5); 7.3750 (1.1); 7.3591 (0.6); 7.3539 (0.7); 7.2599 (66.4); 7,0002 (1.6); 6.9959 (0.7); 6.9820 (1.8); 6.9792 (1.7); 6.9610 (1.4); 6.9536 (0.5); 5.2982 (0.5); 2.6407 (0.6); 2.6344 (0.7); 2.6170 (1.1); 2.5999 (0.6); 1.8738 (0.5); 1.8460 (3.2); 1.8288 (8.1); 1.8185 (6.9); 1.5461 (16.0); 1.2210 (0.8); 1.2064 (4.4);

1.1908 (3.9); 0.0079 (0.9); -0.0002 (24.4); -0.0084 (0.9) 1.1908 (3.9); 0.0079 (0.9); -0.0002 (24.4); -0.0084 (0.9)

1.57-124: 1 H-NMR(400.0 MHz, CDCI3):  1.57-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6251 (4.1); 7.3780 (0.8); 7.2600 (36.3); 7.0042 (1.1); 6.9861 (1.2); 6.9831 (1.1); 6.9651 (1.0); 1.8621 (2.5);δ = 7.6251 (4.1); 7.3780 (0.8); 7.2600 (36.3); 7.0042 (1.1); 6.9861 (1.2); 6.9831 (1.1); 6.9651 (1.0); 1.8621 (2.5);

1.8391 (16.0); 1.5456 (10.7); -0.0002 (13.2) 1.8391 (16.0); 1.5456 (10.7); -0.0002 (13.2)

1.57-136: 1 H-NMR(400.0 MHz, CDCI3):  1.57-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6530 (5.8); 7.4180 (0.6); 7.4128 (0.5); 7.3969 (1.2); 7.3809 (0.5); 7.3758 (0.7); 7.2601 (46.9); 7.0171 (1.7); 6.9988 (1.9); 6.9961 (2.0); 6.9900 (0.6); 6.9778 (1.5); 6.9691 (0.6); 5.2983 (2.8); 2.7817 (0.7); 2.0432 (0.6); 1.8650 (3.1); 1.8462 (16.0); 1.6819 (0.6); 1.6556 (0.7); 1.5446 (14.2); 0.0079 (0.6); -0.0002 (17.0); -0.0085 (0.6) 1.57-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.6530 (5.8); 7.4180 (0.6); 7.4128 (0.5); 7.3969 (1.2); 7.3809 (0.5); 7.3758 (0.7); 7.2601 (46.9); 7.0171 (1.7); 6.9988 (1.9); 6.9961 (2.0); 6.9900 (0.6); 6.9778 (1.5); 6.9691 (0.6); 5.2983 (2.8); 2.7817 (0.7); 2.0432 (0.6); 1.8650 (3.1); 1.8462 (16.0); 1.6819 (0.6); 1.6556 (0.7); 1.5446 (14.2); 0.0079 (0.6); -0.0002 (17.0); -0.0085 (0.6) 1.57-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6627 (4.4); 7.3920 (0.8); 7.2601 (36.5); 7.0126 (1.1); 6.9944 (1.3); 6.9915 (1.1); 6.9734 (1.0); 5.2982 (0.7);δ = 7.6627 (4.4); 7.3920 (0.8); 7.2601 (36.5); 7.0126 (1.1); 6.9944 (1.3); 6.9915 (1.1); 6.9734 (1.0); 5.2982 (0.7);

1.8721 (2.5); 1.8520 (16.0); 1.5455 (8.4); -0.0002 (13.2) 1.8721 (2.5); 1.8520 (16.0); 1.5455 (8.4); -0.0002 (13.2)

1.57-167: 1 H-NMR(400.0 MHz, CDCI3):  1.57-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6391 (3.9); 7.3787 (0.7); 7.2600 (38.2); 7.0039 (1.0); 6.9857 (1.1); 6.9828 (1.0); 6.9647 (0.9); 1.8691 (2.5);δ = 7.6391 (3.9); 7.3787 (0.7); 7.2600 (38.2); 7.0039 (1.0); 6.9857 (1.1); 6.9828 (1.0); 6.9647 (0.9); 1.8691 (2.5);

1.8460 (16.0); 1.5482 (13.6); -0.0002 (13.6) 1.8460 (16.0); 1.5482 (13.6); -0.0002 (13.6)

I.57-353: 1 H-NMR(400.0 MHz, CDCI3):  I.57-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3183 (0.7); 7.7725 (4.1); 7.4314 (0.8); 7.2598 (61.8); 7.2096 (0.5); 7.0576 (1.2); 7.0390 (1.4); 7.0366 (1.3); 7.0180 (1.2); 3.9136 (1.2); 3.9085 (0.8); 3.9029 (1.2); 3.8993 (0.9); 3.8916 (1.3); 3.6505 (1.2); 3.6392 (1.2); 3.6285δ = 9.3183 (0.7); 7.7725 (4.1); 7.4314 (0.8); 7.2598 (61.8); 7.2096 (0.5); 7.0576 (1.2); 7.0390 (1.4); 7.0366 (1.3); 7.0180 (1.2); 3.9136 (1.2); 3.9085 (0.8); 3.9029 (1.2); 3.8993 (0.9); 3.8916 (1.3); 3.6505 (1.2); 3.6392 (1.2); 3.6285

(0.9); 1.9242 (3.3); 1.9115 (16.0); 1.5462 (0.6); 0.0080 (0.7); -0.0002 (24.0); -0.0085 (0.9) (0.9); 1.9242 (3.3); 1.9115 (16.0); 1.5462 (0.6); 0.0080 (0.7); -0.0002 (24.0); -0.0085 (0.9)

1.61-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.61-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6592 (1.0); 8.6555 (1.1); 8.6475 (1.1); 8.6438 (1.1); 7.8574 (1.2); 7.8537 (1.2); 7.8369 (1.3); 7.8332 (1.2); 7.7501 (4.7); 7.3540 (1.3); 7.3424 (1.3); 7.3336 (1.2); 7.3219 (1.2); 7.2611 (21.6); 2.6616 (0.6); 2.6532 (0.6); 1.8613 (16.0); 1.5662 (2.5); 0.7236 (0.6); 0.7215 (0.8); 0.7181 (1.3); 0.7152 (0.6); 0.7054 (0.9); 0.7039 (1.1); 0.7002 (1.0);δ = 8.6592 (1.0); 8.6555 (1.1); 8.6475 (1.1); 8.6438 (1.1); 7.8574 (1.2); 7.8537 (1.2); 7.8369 (1.3); 7.8332 (1.2); 7.7501 (4.7); 7.3540 (1.3); 7.3424 (1.3); 7.3336 (1.2); 7.3219 (1.2); 7.2611 (21.6); 2.6616 (0.6); 2.6532 (0.6); 1.8613 (16.0); 1.5662 (2.5); 0.7236 (0.6); 0.7215 (0.8); 0.7181 (1.3); 0.7152 (0.6); 0.7054 (0.9); 0.7039 (1.1); 0.7002 (1.0);

0.6973 (0.5); 0.4043 (0.8); 0.4012 (1.0); 0.3979 (0.9); 0.3951 (0.8); 0.3915 (1.0); 0.3881 (0.8); -0.0002 (8.5) 0.6973 (0.5); 0.4043 (0.8); 0.4012 (1.0); 0.3979 (0.9); 0.3951 (0.8); 0.3915 (1.0); 0.3881 (0.8); -0.0002 (8.5)

1.61-152: 1 H-NMR(400.0 MHz, CDCI3):  1.61-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6472 (1.0); 8.6436 (1.0); 8.6355 (1.0); 8.6319 (1.0); 7.8361 (1.0); 7.8324 (1.0); 7.8157 (1.1); 7.8120 (1.0); 7.6369 (3.7); 7.3406 (1.1); 7.3289 (1.0); 7.3202 (1.0); 7.3086 (1.0); 7.2598 (61.6); 5.2983 (0.5); 1.8957 (0.8); 1.8567δ = 8.6472 (1.0); 8.6436 (1.0); 8.6355 (1.0); 8.6319 (1.0); 7.8361 (1.0); 7.8324 (1.0); 7.8157 (1.1); 7.8120 (1.0); 7.6369 (3.7); 7.3406 (1.1); 7.3289 (1.0); 7.3202 (1.0); 7.3086 (1.0); 7.2598 (61.6); 5.2983 (0.5); 1.8957 (0.8); 1.8567

(16.0); 1.2557 (2.0); 0.0080 (0.8); -0.0002 (24.2); -0.0083 (1.0) (16.0); 1.2557 (2.0); 0.0080 (0.8); -0.0002 (24.2); -0.0083 (1.0)

1.61-2: 1 H-NMR(400.0 MHz, CDCI3):  1.61-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7186 (0.6); 8.7152 (0.6); 8.7067 (0.6); 8.7032 (0.6); 8.6685 (1.0); 8.6649 (1.0); 8.6569 (1.0); 8.6533 (1.0); 7.8785 (1.6); 7.8749 (1.6); 7.8581 (1.7); 7.8545 (1.6); 7.7536 (4.2); 7.7500 (2.1); 7.5284 (0.6); 7.5192 (0.5); 7.3793 (1.2); 7.3765 (0.8); 7.3677 (1.2); 7.3645 (0.8); 7.3589 (1.1); 7.3561 (0.7); 7.3472 (1.1); 7.3442 (0.7); 7.2602 (46.9); 3.4881 (1.2); 1.9033 (5.3); 1.8945 (1.5); 1.8703 (16.0); 1.5183 (0.7); 1.5032 (1.6); 1.4974 (1.8); 1.4830 (1.0); 1.2552δ = 8.7186 (0.6); 8.7152 (0.6); 8.7067 (0.6); 8.7032 (0.6); 8.6685 (1.0); 8.6649 (1.0); 8.6569 (1.0); 8.6533 (1.0); 7.8785 (1.6); 7.8749 (1.6); 7.8581 (1.7); 7.8545 (1.6); 7.7536 (4.2); 7.7500 (2.1); 7.5284 (0.6); 7.5192 (0.5); 7.3793 (1.2); 7.3765 (0.8); 7.3677 (1.2); 7.3645 (0.8); 7.3589 (1.1); 7.3561 (0.7); 7.3472 (1.1); 7.3442 (0.7); 7.2602 (46.9); 3.4881 (1.2); 1.9033 (5.3); 1.8945 (1.5); 1.8703 (16.0); 1.5183 (0.7); 1.5032 (1.6); 1.4974 (1.8); 1.4830 (1.0); 1.2552

(0.6); 1.1483 (0.8); 1.1338 (1.6); 1.1280 (1.8); 1.1129 (0.8); -0.0002 (17.6); -0.0083 (1.3) (0.6); 1.1483 (0.8); 1.1338 (1.6); 1.1280 (1.8); 1.1129 (0.8); -0.0002 (17.6); -0.0083 (1.3)

1.61-353: 1 H-NMR(400.0 MHz, CDCI3):  1.61-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.5149 (0.8); 8.6444 (1.0); 8.6407 (1.0); 8.6326 (1.0); 8.6290 (1.0); 7.8840 (1.0); 7.8803 (1.0); 7.8636 (1.1); 7.8599 (1.1); 7.7699 (4.0); 7.3844 (1.1); 7.3727 (1.0); 7.3640 (1.0); 7.3522 (1.0); 7.2599 (80.6); 3.9150 (1.2); 3.9099 (0.5); 3.9041 (1.3); 3.9003 (0.8); 3.8973 (0.6); 3.8928 (1.5); 3.6867 (1.0); 3.6754 (1.1); 3.6646 (0.9); 2.9554 (0.7);δ = 9.5149 (0.8); 8.6444 (1.0); 8.6407 (1.0); 8.6326 (1.0); 8.6290 (1.0); 7.8840 (1.0); 7.8803 (1.0); 7.8636 (1.1); 7.8599 (1.1); 7.7699 (4.0); 7.3844 (1.1); 7.3727 (1.0); 7.3640 (1.0); 7.3522 (1.0); 7.2599 (80.6); 3.9150 (1.2); 3.9099 (0.5); 3.9041 (1.3); 3.9003 (0.8); 3.8973 (0.6); 3.8928 (1.5); 3.6867 (1.0); 3.6754 (1.1); 3.6646 (0.9); 2.9554 (0.7);

2.8842 (0.6); 2.8828 (0.6); 1.9132 (16.0); 1.5633 (0.8); 0.0080 (0.9); -0.0002 (30.6); -0.0085 (1.2) 2.8842 (0.6); 2.8828 (0.6); 1.9132 (16.0); 1.5633 (0.8); 0.0080 (0.9); -0.0002 (30.6); -0.0085 (1.2)

1.71-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4919 (1.6); 7.4900 (1.6); 7.3507 (0.8); 7.2597 (19.9); 7.0219 (1.0); 7.0026 (1.2); 7.0012 (1.1); 6.9820 (0.8); 2.7103 (0.6); 2.7006 (0.6); 2.0161 (4.4); 2.0142 (4.4); 1.8492 (16.0); 1.5466 (3.2); 0.7079 (0.9); 0.7044 (1.2); 0.6903δ = 7.4919 (1.6); 7.4900 (1.6); 7.3507 (0.8); 7.2597 (19.9); 7.0219 (1.0); 7.0026 (1.2); 7.0012 (1.1); 6.9820 (0.8); 2.7103 (0.6); 2,7006 (0.6); 2.0161 (4.4); 2.0142 (4.4); 1.8492 (16.0); 1.5466 (3.2); 0.7079 (0.9); 0.7044 (1.2); 0.6903

(1.1) ; 0.6864 (0.9); 0.6837 (0.5); 0.4132 (0.8); 0.4103 (0.9); 0.4066 (0.9); 0.4005 (0.9); 0.3970 (0.8); -0.0002 (11.4) 1.71-2: 1 H-NMR(400.0 MHz, CDCI3): (1.1); 0.6864 (0.9); 0.6837 (0.5); 0.4132 (0.8); 0.4103 (0.9); 0.4066 (0.9); 0.4005 (0.9); 0.3970 (0.8); -0.0002 (11.4) 1.71-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4779 (1.6); 7.4759 (1.6); 7.3511 (0.8); 7.2605 (14.5); 7.0237 (1.0); 7.0046 (1.1); 7.0029 (1.0); 6.9838 (0.8); 2.0165 (4.3); 2.0146 (4.2); 1.8239 (16.0); 1.5647 (2.6); 1.3084 (6.1); 0.6162 (1.1); 0.6057 (0.6); 0.6020 (0.6); 0.5736δ = 7.4779 (1.6); 7.4759 (1.6); 7.3511 (0.8); 7.2605 (14.5); 7.0237 (1.0); 7.0046 (1.1); 7.0029 (1.0); 6.9838 (0.8); 2.0165 (4.3); 2.0146 (4.2); 1.8239 (16.0); 1.5647 (2.6); 1.3084 (6.1); 0.6162 (1.1); 0.6057 (0.6); 0.6020 (0.6); 0.5736

(0.5); 0.5702 (0.9); 0.5622 (1.0); 0.5601 (1.2); 0.5589 (1.2); -0.0002 (5.1) (0.5); 0.5702 (0.9); 0.5622 (1.0); 0.5601 (1.2); 0.5589 (1.2); -0.0002 (5.1)

1.71-3: 1 H-NMR(400.0 MHz, CDCI3):  1.71-3: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4937 (1.8); 7.4917 (1.7); 7.3749 (0.8); 7.2595 (41.2); 7.0417 (1.1); 7.0220 (1.4); 7.0015 (0.9); 2.0278 (4.6); 2.0259 (4.5); 1.8903 (0.7); 1.8552 (16.0); 1.5360 (3.0); 1.5097 (0.7); 1.4946 (1.5); 1.4888 (1.6); 1.4744 (0.8); 1.1483δ = 7.4937 (1.8); 7.4917 (1.7); 7.3749 (0.8); 7.2595 (41.2); 7.0417 (1.1); 7.0220 (1.4); 7.0015 (0.9); 2.0278 (4.6); 2.0259 (4.5); 1.8903 (0.7); 1.8552 (16.0); 1.5360 (3.0); 1.5097 (0.7); 1.4946 (1.5); 1.4888 (1.6); 1.4744 (0.8); 1.1483

(0.8); 1.1338 (1.5); 1.1280 (1.5); 1.1128 (0.7); -0.0002 (14.9) (0.8); 1.1338 (1.5); 1.1280 (1.5); 1.1128 (0.7); -0.0002 (14.9)

1.71-4: 1 H-NMR(400.0 MHz, CDCI3):  1.71-4: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5155 (2.0); 7.5136 (1.9); 7.3517 (0.8); 7.3307 (0.5); 7.2880 (0.7); 7.2614 (11.4); 7.0195 (1.1); 7.0003 (1.4); 6.9797 (1.0); 4.1251 (0.9); 4.1072 (2.8); 4.0894 (2.8); 4.0715 (0.9); 2.0211 (5.3); 2.0194 (5.1); 1.8768 (16.0); 1.5784δ = 7.5155 (2.0); 7.5136 (1.9); 7.3517 (0.8); 7.3307 (0.5); 7.2880 (0.7); 7.2614 (11.4); 7.0195 (1.1); 7,0003 (1.4); 6.9797 (1.0); 4.1251 (0.9); 4.1072 (2.8); 4.0894 (2.8); 4.0715 (0.9); 2.0211 (5.3); 2.0194 (5.1); 1.8768 (16.0); 1.5784

(1.2) ; 1.5105 (0.8); 1.4984 (2.1); 1.4903 (2.1); 1.4788 (0.8); 1.2208 (2.9); 1.2030 (6.0); 1.1851 (2.8); 1.0390 (0.8);(1.2); 1.5105 (0.8); 1.4984 (2.1); 1.4903 (2.1); 1.4788 (0.8); 1.2208 (2.9); 1.2030 (6.0); 1.1851 (2.8); 1.0390 (0.8);

1.0276 (2.0); 1.0194 (2.0); 1.0073 (0.7); -0.0002 (4.0) 1.0276 (2.0); 1.0194 (2.0); 1.0073 (0.7); -0.0002 (4.0)

1.71-5: 1 H-NMR(400.0 MHz, CDCI3):  1.71-5: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4985 (1.6); 7.4971 (1.6); 7.3610 (0.8); 7.2596 (25.2); 7.0300 (1.0); 7.0105 (1.3); 6.9904 (0.9); 2.0253 (4.5); 2.0239 (4.5); 1.8475 (16.0); 1.5401 (7.1); 1.2728 (0.6); 1.2573 (1.4); 1.2528 (1.6); 1.2495 (0.8); 1.2381 (0.8); 0.9920δ = 7.4985 (1.6); 7.4971 (1.6); 7.3610 (0.8); 7.2596 (25.2); 7.0300 (1.0); 7.0105 (1.3); 6.9904 (0.9); 2.0253 (4.5); 2.0239 (4.5); 1.8475 (16.0); 1.5401 (7.1); 1.2728 (0.6); 1.2573 (1.4); 1.2528 (1.6); 1.2495 (0.8); 1.2381 (0.8); 0.9920

(1.0); 0.9882 (1.2); -0.0002 (9.2) (1.0); 0.9882 (1.2); -0.0002 (9.2)

1.71-6: 1 H-NMR(400.0 MHz, CDCI3):  1.71-6: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4893 (1.7); 7.4874 (1.6); 7.3499 (0.8); 7.2599 (28.7); 7.0220 (1.0); 7.0030 (1.2); 6.9823 (0.9); 2.0152 (4.5); 2.0134 (4.5); 1.8336 (16.0); 1.5568 (0.6); 1.5479 (8.9); 1.5384 (1.5); 1.5198 (1.6); 1.5014 (0.5); 0.8281 (2.0); 0.8096δ = 7.4893 (1.7); 7.4874 (1.6); 7.3499 (0.8); 7.2599 (28.7); 7.0220 (1.0); 7.0030 (1.2); 6.9823 (0.9); 2.0152 (4.5); 2.0134 (4.5); 1.8336 (16.0); 1.5568 (0.6); 1.5479 (8.9); 1.5384 (1.5); 1.5198 (1.6); 1.5014 (0.5); 0.8281 (2.0); 0.8096

(4.2); 0.7910 (1.8); 0.5989 (1.2); 0.5897 (1.2); 0.5661 (1.3); 0.5578 (1.2); 0.5553 (1.3); -0.0002 (10.0) (4.2); 0.7910 (1.8); 0.5989 (1.2); 0.5897 (1.2); 0.5661 (1.3); 0.5578 (1.2); 0.5553 (1.3); -0.0002 (10.0)

1.71-7: 1 H-NMR(400.0 MHz, CDCI3):  1.71-7: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4900 (1.6); 7.4881 (1.6); 7.3500 (0.8); 7.2599 (26.1); 7.0215 (1.0); 7.0024 (1.2); 7.0007 (1.1); 6.9817 (0.9); 2.0189 (4.4); 2.0171 (4.4); 1.8393 (16.0); 1.5482 (8.0); 1.3132 (0.6); 0.5608 (1.2); 0.5558 (1.9); 0.5518 (1.4); 0.5431 (1.4); 0.5390 (2.0); 0.5339 (1.3); 0.3525 (0.9); 0.3489 (1.0); 0.3317 (1.0); 0.3281 (1.0); 0.0858 (1.1); 0.0828 (1.1);δ = 7.4900 (1.6); 7.4881 (1.6); 7.3500 (0.8); 7.2599 (26.1); 7.0215 (1.0); 7.0024 (1.2); 7,0007 (1.1); 6.9817 (0.9); 2.0189 (4.4); 2.0171 (4.4); 1.8393 (16.0); 1.5482 (8.0); 1.3132 (0.6); 0.5608 (1.2); 0.5558 (1.9); 0.5518 (1.4); 0.5431 (1.4); 0.5390 (2.0); 0.5339 (1.3); 0.3525 (0.9); 0.3489 (1.0); 0.3317 (1.0); 0.3281 (1.0); 0.0858 (1.1); 0.0828 (1.1);

0.0732 (1.0); 0.0701 (1.2); -0.0002 (9.6) 0.0732 (1.0); 0.0701 (1.2); -0.0002 (9.6)

1.71-8: 1 H-NMR(400.0 MHz, CDCI3):  1.71-8: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4899 (1.7); 7.4879 (1.7); 7.3563 (0.8); 7.3352 (0.5); 7.3190 (0.5); 7.2596 (40.4); 7.0263 (1.0); 7.0071 (1.2); 6.9864 (0.9); 6.1314 (0.6); 5.9855 (1.3); 5.8396 (0.6); 2.0215 (4.4); 2.0196 (4.5); 1.9862 (0.9); 1.9846 (0.9); 1.8436 (16.0); 1.8250 (3.1); 1.5403 (5.5); 1.1218 (0.8); 1.1071 (1.5); 1.1028 (1.7); 1.0888 (0.9); 0.7766 (1.1); 0.7719 (1.1); - 0.0002 (14.0); -0.0085 (0.6) 1.71-9: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4899 (1.7); 7.4879 (1.7); 7.3563 (0.8); 7.3352 (0.5); 7.3190 (0.5); 7.2596 (40.4); 7.0263 (1.0); 7.0071 (1.2); 6.9864 (0.9); 6.1314 (0.6); 5.9855 (1.3); 5.8396 (0.6); 2.0215 (4.4); 2.0196 (4.5); 1.9862 (0.9); 1.9846 (0.9); 1.8436 (16.0); 1.8250 (3.1); 1.5403 (5.5); 1.1218 (0.8); 1.1071 (1.5); 1.1028 (1.7); 1.0888 (0.9); 0.7766 (1.1); 0.7719 (1.1); - 0.0002 (14.0); -0.0085 (0.6) 1.71-9: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5128 (1.8); 7.5108 (1.7); 7.3580 (0.8); 7.2603 (17.3); 7.0276 (1.0); 7.0085 (1.2); 7.0069 (1.1); 6.9878 (0.9); 5.2982 (0.8); 3.2275 (10.1); 2.0242 (4.6); 2.0222 (4.5); 1.8663 (16.0); 1.5571 (2.9); 1.0708 (0.6); 1.0572 (1.6); 1.0521δ = 7.5128 (1.8); 7.5108 (1.7); 7.3580 (0.8); 7.2603 (17.3); 7.0276 (1.0); 7.0085 (1.2); 7.0069 (1.1); 6,9888 (0.9); 5.2982 (0.8); 3.2275 (10.1); 2.0242 (4.6); 2.0222 (4.5); 1.8663 (16.0); 1.5571 (2.9); 1.0708 (0.6); 1.0572 (1.6); 1.0521

(1.6); 1.0388 (0.8); 0.8374 (0.8); 0.8239 (1.6); 0.8190 (1.5); 0.8051 (0.6); -0.0002 (6.5) (1.6); 1.0388 (0.8); 0.8374 (0.8); 0.8239 (1.6); 0.8190 (1.5); 0.8051 (0.6); -0.0002 (6.5)

1.71-10: 1 H-NMR(400.0 MHz, CDCI3):  1.71-10: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5041 (1.8); 7.5021 (1.8); 7.3557 (0.8); 7.2600 (26.8); 7.0245 (1.0); 7.0055 (1.3); 7.0039 (1.2); 6.9847 (0.9); 3.5358 (0.7); 3.5181 (2.4); 3.5004 (2.4); 3.4827 (0.8); 2.0213 (4.7); 2.0195 (4.7); 1.8579 (16.0); 1.5487 (5.3); 1.1100δ = 7.5041 (1.8); 7.5021 (1.8); 7.3557 (0.8); 7.2600 (26.8); 7.0245 (1.0); 7.0055 (1.3); 7.0039 (1.2); 6.9847 (0.9); 3.5358 (0.7); 3.5181 (2.4); 3.5004 (2.4); 3.4827 (0.8); 2.0213 (4.7); 2.0195 (4.7); 1.8579 (16.0); 1.5487 (5.3); 1.1100

(2.6) ; 1.0923 (5.4); 1.0745 (2.6); 1.0702 (0.8); 1.0564 (1.7); 1.0513 (1.7); 1.0381 (0.9); 0.8383 (0.8); 0.8250 (1.6);(2.6); 1.0923 (5.4); 1.0745 (2.6); 1.0702 (0.8); 1.0564 (1.7); 1.0513 (1.7); 1.0381 (0.9); 0.8383 (0.8); 0.8250 (1.6);

0.8199 (1.6); 0.8061 (0.6); -0.0002 (9.9) 0.8199 (1.6); 0.8061 (0.6); -0.0002 (9.9)

1.71-11 : 1 H-NMR(599.8 MHz, CDCI3):  1.71-11: 1 H-NMR (599.8 MHz, CDCl 3):

δ= 8.4692 (0.9); 7.5274 (6.8); 7.5266 (6.8); 7.4021 (1.3); 7.3915 (2.1); 7.3882 (2.0); 7.3808 (1.3); 7.3775 (2.9); 7.3743 (1.2); 7.3668 (1.5); 7.3635 (1.6); 7.3528 (0.8); 7.2647 (7.4); 7.0310 (0.3); 7.0285 (0.5); 7.0218 (3.9); 7.0171 (0.7); 7.0144 (0.8); 7.0087 (5.3); 7.0031 (0.9); 7.0001 (0.8); 6.9955 (3.8); 6.9886 (0.6); 6.7482 (2.4); 5.2998 (11.4); 2.0496 (2.4); 2.0419 (7.2); 2.0360 (7.7); 2.0285 (21.9); 2.0189 (1.6); 2.0119 (3.0); 2.0064 (3.0); 1.9997 (1.1); 1.9911 (0.3); 1.8854 (2.4); 1.8695 (0.4); 1.8530 (0.7); 1.7965 (50.0); 1.7773 (0.7); 1.6864 (0.4); 1.6377 (0.8); 1.2561 (0.5); 1.2110 (2.6); 1.2034 (7.3); 1.1976 (7.3); 1.1898 (2.6); 1.1140 (0.9); 1.1072 (2.8); 1.1016 (2.8); 1.0947 (1.0); -0.0001δ = 8.4692 (0.9); 7.5274 (6.8); 7.5266 (6.8); 7.4021 (1.3); 7.3915 (2.1); 7.3882 (2.0); 7.3808 (1.3); 7.3775 (2.9); 7.3743 (1.2); 7.3668 (1.5); 7.3635 (1.6); 7.3528 (0.8); 7.2647 (7.4); 7.0310 (0.3); 7.0285 (0.5); 7.0218 (3.9); 7.0171 (0.7); 7.0144 (0.8); 7.0087 (5.3); 7.0031 (0.9); 7,0001 (0.8); 6.9955 (3.8); 6.9886 (0.6); 6.7482 (2.4); 5.2998 (11.4); 2.0496 (2.4); 2.0419 (7.2); 2.0360 (7.7); 2.0285 (21.9); 2.0189 (1.6); 2.0119 (3.0); 2.0064 (3.0); 1.9997 (1.1); 1.9911 (0.3); 1.8854 (2.4); 1.8695 (0.4); 1.8530 (0.7); 1.7965 (50.0); 1.7773 (0.7); 1.6864 (0.4); 1.6377 (0.8); 1.2561 (0.5); 1.2110 (2.6); 1.2034 (7.3); 1.1976 (7.3); 1.1898 (2.6); 1.1140 (0.9); 1.1072 (2.8); 1.1016 (2.8); 1.0947 (1.0); -0.0001

(6-7) (6-7)

1.71-12: 1 H-NMR(400.0 MHz, CDCI3):  1.71-12: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3439 (1.2); 7.3336 (2.4); 7.3282 (2.4); 7.3232 (1.6); 7.3121 (0.9); 7.3071 (2.7); 7.3019 (0.9); 7.2914 (1.2); 7.2860 (1.6); 7.2701 (1.0); 7.2614 (37.5); 6.9836 (0.6); 6.9728 (3.4); 6.9630 (0.6); 6.9539 (3.8); 6.9520 (3.4); 6.9434 (0.6); 6.9333 (2.8); 5.2979 (0.6); 2.7344 (1.3); 2.7224 (1.3); 2.5838 (0.8); 2.5472 (0.5); 2.0288 (1.1); 2.0269 (1.0); 1.9863 (16.0); 1.9849 (15.0); 1.8841 (0.6); 1.8666 (4.2); 1.8442 (16.0); 1.8329 (3.1); 1.5833 (1.9); 1.2567 (0.8);δ = 7.3439 (1.2); 7.3336 (2.4); 7.3282 (2.4); 7.3232 (1.6); 7.3121 (0.9); 7.3071 (2.7); 7.3019 (0.9); 7.2914 (1.2); 7.2860 (1.6); 7.2701 (1.0); 7.2614 (37.5); 6.9836 (0.6); 6.9728 (3.4); 6.9630 (0.6); 6.9539 (3.8); 6.9520 (3.4); 6.9434 (0.6); 6.9333 (2.8); 5.2979 (0.6); 2.7344 (1.3); 2.7224 (1.3); 2.5838 (0.8); 2.5472 (0.5); 2.0288 (1.1); 2.0269 (1.0); 1.9863 (16.0); 1.9849 (15.0); 1.8841 (0.6); 1.8666 (4.2); 1.8442 (16.0); 1.8329 (3.1); 1.5833 (1.9); 1.2567 (0.8);

0.7045 (0.7); 0.6044 (1.1); 0.5924 (3.0); 0.5862 (2.6); 0.5818 (2.6); 0.5765 (2.0); 0.5636 (0.6); -0.0002 (12.8) 0.7045 (0.7); 0.6044 (1.1); 0.5924 (3.0); 0.5862 (2.6); 0.5818 (2.6); 0.5765 (2.0); 0.5636 (0.6); -0.0002 (12.8)

1.71-13: 1 H-NMR(599.8 MHz, CDCI3):  1.71-13: 1 H-NMR (599.8 MHz, CDCl 3):

δ= 7.3661 (7.1); 7.3650 (6.7); 7.3469 (0.6); 7.3362 (1.3); 7.3329 (1.3); 7.3222 (2.5); 7.3190 (1.0); 7.3115 (1.4); 7.3082 (1.4); 7.2976 (0.6); 7.2643 (5.3); 6.9821 (0.4); 6.9754 (3.6); 6.9625 (5.2); 6.9489 (3.2); 6.9419 (0.4); 2.4944 (28.3); 1.9982 (19.4); 1.8286 (50.0); 1.6163 (2.0); 1.5676 (2.0); 1.5573 (5.5); 1.5533 (5.6); 1.5435 (2.3); 1.2977 (2.2);δ = 7.3661 (7.1); 7.3650 (6.7); 7.3469 (0.6); 7.3362 (1.3); 7.3329 (1.3); 7.3222 (2.5); 7.3190 (1.0); 7.3115 (1.4); 7.3082 (1.4); 7.2976 (0.6); 7.2643 (5.3); 6.9821 (0.4); 6.9754 (3.6); 6.9625 (5.2); 6.9489 (3.2); 6.9419 (0.4); 2.4944 (28.3); 1.9982 (19.4); 1.8286 (50.0); 1.6163 (2.0); 1.5676 (2.0); 1.5573 (5.5); 1.5533 (5.6); 1.5435 (2.3); 1.2977 (2.2);

1.2879 (5.8); 1.2841 (5.9); 1.2739 (1.9); 1.2566 (0.4); -0.0001 (4.7) 1.2879 (5.8); 1.2841 (5.9); 1.2739 (1.9); 1.2566 (0.4); -0.0001 (4.7)

1.71-14: 1 H-NMR(400.0 MHz, CDCI3):  1.71-14: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4888 (4.2); 7.4868 (4.2); 7.3852 (1.0); 7.3801 (0.8); 7.3691 (0.6); 7.3641 (2.0); 7.3591 (0.7); 7.3479 (0.8); 7.3430 (1.2); 7.3270 (0.6); 7.2599 (42.4); 7.0333 (2.5); 7.0137 (3.1); 7.0039 (0.5); 6.9956 (1.3); 6.9931 (2.2); 6.9207 (0.7); 4.5467 (0.6); 4.5436 (0.6); 4.5385 (0.6); 4.5354 (0.6); 4.5296 (0.6); 4.5266 (0.6); 4.5215 (0.6); 4.5184 (0.6); 4.3919 (0.6); 4.3889 (0.6); 4.3838 (0.6); 4.3808 (0.6); 4.3749 (0.6); 4.3719 (0.6); 4.3668 (0.6); 4.3637 (0.6); 3.0714 (0.5); 3.0683 (0.5); 3.0621 (0.5); 3.0591 (0.5); 2.0194 (10.9); 2.0175 (11.0); 1.8478 (16.0); 1.8374 (15.8); 1.5951 (0.6); 1.3936 (0.5); 1.3854 (0.5); 1.3733 (0.6); 1.3691 (0.6); 1.3651 (0.7); 1.3609 (0.6); 1.3488 (0.6); 1.3406 (0.6); 1.3350 (0.6); 1.3268 (0.5); 1.3146 (0.6); 1.3104 (0.6); 1.3065 (0.6); 1.3023 (0.6); 1.2901 (0.6); 1.2819 (0.6); 0.8675 (0.5); 0.8534 (0.6); 0.8504 (0.6); 0.8472 (0.6); 0.8390 (0.6); 0.8364 (0.7); 0.8331 (0.6); 0.8301 (0.6); 0.8250 (0.6); 0.8220 (0.6); 0.8187 (0.6); 0.8161 (0.6); 0.8079 (0.6); 0.8047 (0.6); 0.8018 (0.5); 0.0080 (0.6); -0.0002 (18.4); -δ = 7.4888 (4.2); 7.4868 (4.2); 7.3852 (1.0); 7.3801 (0.8); 7.3691 (0.6); 7.3641 (2.0); 7.3591 (0.7); 7.3479 (0.8); 7.3430 (1.2); 7.3270 (0.6); 7.2599 (42.4); 7.0333 (2.5); 7.0137 (3.1); 7.0039 (0.5); 6.9956 (1.3); 6.9931 (2.2); 6.9207 (0.7); 4.5467 (0.6); 4.5436 (0.6); 4.5385 (0.6); 4.5354 (0.6); 4.5296 (0.6); 4.5266 (0.6); 4.5215 (0.6); 4.5184 (0.6); 4.3919 (0.6); 4.3889 (0.6); 4.3838 (0.6); 4.3808 (0.6); 4.3749 (0.6); 4.3719 (0.6); 4.3668 (0.6); 4.3637 (0.6); 3.0714 (0.5); 3.0683 (0.5); 3.0621 (0.5); 3.0591 (0.5); 2.0194 (10.9); 2.0175 (11.0); 1.8478 (16.0); 1.8374 (15.8); 1.5951 (0.6); 1.3936 (0.5); 1.3854 (0.5); 1.3733 (0.6); 1.3691 (0.6); 1.3651 (0.7); 1.3609 (0.6); 1.3488 (0.6); 1.3406 (0.6); 1.3350 (0.6); 1.3268 (0.5); 1.3146 (0.6); 1.3104 (0.6); 1.3065 (0.6); 1.3023 (0.6); 1.2901 (0.6); 1.2819 (0.6); 0.8675 (0.5); 0.8534 (0.6); 0.8504 (0.6); 0.8472 (0.6); 0.8390 (0.6); 0.8364 (0.7); 0.8331 (0.6); 0.8301 (0.6); 0.8250 (0.6); 0.8220 (0.6); 0.8187 (0.6); 0.8161 (0.6); 0.8079 (0.6); 0.8047 (0.6); 0.8018 (0.5); 0.0080 (0.6); -0.0002 (18.4); -

0.0085 (0.5) 0.0085 (0.5)

1.71-15: 1 H-NMR(400.0 MHz, CDCI3):  1.71-15: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5119 (0.7); 7.5099 (0.7); 7.4871 (2.9); 7.4851 (2.8); 7.3710 (0.8); 7.3656 (0.6); 7.3499 (1.5); 7.3448 (0.5); 7.3335 (0.7); 7.3289 (0.9); 7.2598 (69.5); 7.0218 (1.7); 7.0025 (2.1); 7.0010 (2.0); 6.9960 (0.9); 6.9818 (1.5); 2.3913 (0.6); 2.3823 (0.9); 2.3729 (0.9); 2.3640 (0.7); 2.0138 (8.8); 2.0119 (8.8); 1.8791 (2.6); 1.8716 (2.7); 1.8438 (16.0); 1.2556 (0.5); 1.0588 (6.3); 1.0435 (7.0); 0.8706 (1.7); 0.8562 (1.1); 0.7607 (0.6); 0.7530 (0.5); 0.7456 (0.6); 0.5660 (0.5); 0.5562 (0.6); 0.5524 (0.8); 0.5428 (1.1); 0.5295 (0.6); 0.5198 (0.6); 0.4869 (0.7); 0.4724 (0.9); 0.4687 (0.7);δ = 7.5119 (0.7); 7.5099 (0.7); 7.4871 (2.9); 7.4851 (2.8); 7.3710 (0.8); 7.3656 (0.6); 7.3499 (1.5); 7.3448 (0.5); 7.3335 (0.7); 7.3289 (0.9); 7.2598 (69.5); 7.0218 (1.7); 7.0025 (2.1); 7.0010 (2.0); 6.9960 (0.9); 6.9818 (1.5); 2.3913 (0.6); 2.3823 (0.9); 2.3729 (0.9); 2.3640 (0.7); 2.0138 (8.8); 2.0119 (8.8); 1.8791 (2.6); 1.8716 (2.7); 1.8438 (16.0); 1.2556 (0.5); 1.0588 (6.3); 1.0435 (7.0); 0.8706 (1.7); 0.8562 (1.1); 0.7607 (0.6); 0.7530 (0.5); 0.7456 (0.6); 0.5660 (0.5); 0.5562 (0.6); 0.5524 (0.8); 0.5428 (1.1); 0.5295 (0.6); 0.5198 (0.6); 0.4869 (0.7); 0.4724 (0.9); 0.4687 (0.7);

0.4580 (0.5); 0.4541 (0.9); 0.0080 (0.8); -0.0002 (27.0); -0.0085 (0.8) 0.4580 (0.5); 0.4541 (0.9); 0.0080 (0.8); -0.0002 (27.0); -0.0085 (0.8)

1.71-16: 1 H-NMR(400.0 MHz, CDCI3):  1.71-16: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4877 (3.6); 7.3710 (0.8); 7.3660 (0.7); 7.3500 (1.6); 7.3449 (0.5); 7.3340 (0.8); 7.3289 (0.9); 7.2602 (38.0); 7.0217 (2.2); 7.0023 (2.7); 6.9822 (1.9); 6.7432 (0.7); 2.4095 (0.9); 2.4003 (1.2); 2.3911 (1.1); 2.3826 (0.8); 2.0150 (10.1); 1.8454 (16.0); 1.8424 (16.0); 1.5526 (10.7); 1.3524 (0.7); 1.3350 (1.0); 1.3174 (1.1); 1.2993 (0.8); 1.2488 (0.6); 1.2307 (1.1); 1.2129 (1.0); 1.1955 (0.8); 0.9863 (4.5); 0.9678 (9.4); 0.9495 (3.3); 0.7297 (0.5); 0.7247 (0.6); 0.7162 (0.6); 0.7080 (0.6); 0.6997 (0.5); 0.5305 (1.2); 0.5200 (2.2); 0.5087 (1.3); 0.5026 (2.1); 0.4986 (1.2); 0.4861δ = 7.4877 (3.6); 7.3710 (0.8); 7.3660 (0.7); 7.3500 (1.6); 7.3449 (0.5); 7.3340 (0.8); 7.3289 (0.9); 7.2602 (38.0); 7.0217 (2.2); 7.0023 (2.7); 6.9822 (1.9); 6.7432 (0.7); 2.4095 (0.9); 2.4003 (1.2); 2.3911 (1.1); 2.3826 (0.8); 2.0150 (10.1); 1.8454 (16.0); 1.8424 (16.0); 1.5526 (10.7); 1.3524 (0.7); 1.3350 (1.0); 1.3174 (1.1); 1.2993 (0.8); 1.2488 (0.6); 1.2307 (1.1); 1.2129 (1.0); 1.1955 (0.8); 0.9863 (4.5); 0.9678 (9.4); 0.9495 (3.3); 0.7297 (0.5); 0.7247 (0.6); 0.7162 (0.6); 0.7080 (0.6); 0.6997 (0.5); 0.5305 (1.2); 0.5200 (2.2); 0.5087 (1.3); 0.5026 (2.1); 0.4986 (1.2); 0.4861

(1.2); -0.0002 (13.3) (1.2); -0.0002 (13.3)

1.71-17: 1 H-NMR(400.0 MHz, CDCI3):  1.71-17: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4933 (2.3); 7.3589 (0.8); 7.3381 (0.5); 7.2599 (23.8); 7.0284 (1.2); 7.0090 (1.8); 6.9897 (1.1); 2.7926 (5.4); 2.0206 (6.4); 1.8900 (0.5); 1.8424 (16.0); 1.5425 (6.4); 0.8702 (2.0); 0.8576 (1.7); 0.8268 (1.5); 0.8137 (2.0); 0.7944δ = 7.4933 (2.3); 7.3589 (0.8); 7.3381 (0.5); 7.2599 (23.8); 7.0284 (1.2); 7.0090 (1.8); 6.9897 (1.1); 2.7926 (5.4); 2.0206 (6.4); 1.8900 (0.5); 1.8424 (16.0); 1.5425 (6.4); 0.8702 (2.0); 0.8576 (1.7); 0.8268 (1.5); 0.8137 (2.0); 0.7944

(0.6); -0.0002 (8.4) (0.6); -0.0002 (8.4)

1.71-18: 1 H-NMR(400.0 MHz, CDCI3):  1.71-18: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4975 (3.5); 7.4956 (3.6); 7.3684 (0.9); 7.3634 (0.7); 7.3474 (1.7); 7.3423 (0.6); 7.3313 (0.7); 7.3264 (1.0); 7.3104 (0.6); 7.2598 (64.6); 7.0183 (2.1); 6.9992 (2.4); 6.9975 (2.3); 6.9785 (1.8); 6.5872 (0.6); 2.0136 (9.5); 2.0117δ = 7.4975 (3.5); 7.4956 (3.6); 7.3684 (0.9); 7.3634 (0.7); 7.3474 (1.7); 7.3423 (0.6); 7.3313 (0.7); 7.3264 (1.0); 7.3104 (0.6); 7.2598 (64.6); 7.0183 (2.1); 6.9992 (2.4); 6.9975 (2.3); 6.9785 (1.8); 6.5872 (0.6); 2.0136 (9.5); 2.0117

(9.7) ; 1.8531 (15.7); 1.8505 (16.0); 1.5476 (19.2); 1.2775 (13.9); 0.8888 (4.3); 0.8742 (7.9); 0.8168 (0.7); 0.8104 (0.8); 0.7951 (0.9); 0.6845 (1.4); 0.6713 (1.4); 0.6631 (1.0); 0.6502 (1.0); 0.1805 (0.9); 0.1664 (1.6); 0.1527 (0.8); 0.0080 (0.7); -0.0002 (23.7); -0.0085 (0.7) 1.71-19: 1 H-NMR(400.0 MHz, CDCI3): (9.7); 1.8531 (15.7); 1.8505 (16.0); 1.5476 (19.2); 1.2775 (13.9); 0.8888 (4.3); 0.8742 (7.9); 0.8168 (0.7); 0.8104 (0.8); 0.7951 (0.9); 0.6845 (1.4); 0.6713 (1.4); 0.6631 (1.0); 0.6502 (1.0); 0.1805 (0.9); 0.1664 (1.6); 0.1527 (0.8); 0.0080 (0.7); -0.0002 (23.7); -0.0085 (0.7) 1.71-19: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5202 (0.5); 7.5187 (0.7); 7.4969 (4.2); 7.4949 (4.2); 7.4056 (0.5); 7.3895 (1.1); 7.3844 (0.8); 7.3734 (0.6); 7.3684 (2.0); 7.3635 (0.7); 7.3520 (0.8); 7.3473 (1.3); 7.3312 (0.6); 7.2600 (55.0); 7.2100 (0.7); 7.0392 (2.6); 7.0285 (0.6); 7.0194 (3.2); 7.0099 (0.8); 6.9988 (2.2); 5.2982 (1.0); 3.0778 (0.8); 3.0748 (0.6); 3.0660 (1.2); 3.0571 (1.2); 3.0483 (0.5); 3.0453 (0.8); 2.0253 (10.9); 2.0232 (11.4); 1.8796 (1.8); 1.8727 (1.8); 1.8527 (15.9); 1.8471 (16.0); 1.6181 (0.5); 1.6096 (0.8); 1.6011 (0.8); 1.5927 (0.8); 1.5841 (0.6); 1.5476 (5.6); 1.2221 (0.7); 1.2063 (1.4); 1.2018 (0.8); 1.1906 (0.8); 1.1859 (1.4); 1.1702 (0.7); 1.0850 (1.9); 0.9788 (0.5); 0.9662 (0.7); 0.9541 (0.7); 0.9419 (0.7);δ = 7.5202 (0.5); 7.5187 (0.7); 7.4969 (4.2); 7.4949 (4.2); 7.4056 (0.5); 7.3895 (1.1); 7.3844 (0.8); 7.3734 (0.6); 7.3684 (2.0); 7.3635 (0.7); 7.3520 (0.8); 7.3473 (1.3); 7.3312 (0.6); 7.2600 (55.0); 7.2100 (0.7); 7.0392 (2.6); 7.0285 (0.6); 7.0194 (3.2); 7.0099 (0.8); 6.9988 (2.2); 5.2982 (1.0); 3.0778 (0.8); 3.0748 (0.6); 3.0660 (1.2); 3.0571 (1.2); 3.0483 (0.5); 3.0453 (0.8); 2.0253 (10.9); 2.0232 (11.4); 1.8796 (1.8); 1.8727 (1.8); 1.8527 (15.9); 1.8471 (16.0); 1.6181 (0.5); 1.6096 (0.8); 1.6011 (0.8); 1.5927 (0.8); 1.5841 (0.6); 1.5476 (5.6); 1.2221 (0.7); 1.2063 (1.4); 1.2018 (0.8); 1.1906 (0.8); 1.1859 (1.4); 1.1702 (0.7); 1.0850 (1.9); 0.9788 (0.5); 0.9662 (0.7); 0.9541 (0.7); 0.9419 (0.7);

0.0080 (0.6); -0.0002 (20.4); -0.0085 (0.6) 0.0080 (0.6); -0.0002 (20.4); -0.0085 (0.6)

1.71-20: 1 H-NMR(400.0 MHz, CDCI3):  1.71-20: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5077 (3.6); 7.5058 (3.6); 7.3675 (0.9); 7.3626 (0.7); 7.3515 (0.6); 7.3464 (1.7); 7.3413 (0.6); 7.3304 (0.7); 7.3253 (1.0); 7.3094 (0.5); 7.2612 (22.6); 7.0150 (2.2); 6.9959 (2.6); 6.9943 (2.4); 6.9752 (1.9); 6.5391 (0.6); 2.4613 (0.7); 2.4510 (1.4); 2.4412 (1.4); 2.4314 (1.4); 2.4211 (0.7); 2.0113 (9.6); 2.0094 (9.4); 1.8711 (16.0); 1.8687 (15.8); 1.5810 (1.5); 1.0606 (15.3); 0.8845 (15.1); 0.6649 (1.1); 0.6513 (1.3); 0.6454 (1.2); 0.6317 (1.1); 0.2258 (1.1); 0.2142δ = 7.5077 (3.6); 7.5058 (3.6); 7.3675 (0.9); 7.3626 (0.7); 7.3515 (0.6); 7.3464 (1.7); 7.3413 (0.6); 7.3304 (0.7); 7.3253 (1.0); 7.3094 (0.5); 7.2612 (22.6); 7.0150 (2.2); 6.9959 (2.6); 6.9943 (2.4); 6.9752 (1.9); 6.5391 (0.6); 2.4613 (0.7); 2.4510 (1.4); 2.4412 (1.4); 2.4314 (1.4); 2.4211 (0.7); 2.0113 (9.6); 2.0094 (9.4); 1.8711 (16.0); 1.8687 (15.8); 1.5810 (1.5); 1.0606 (15.3); 0.8845 (15.1); 0.6649 (1.1); 0.6513 (1.3); 0.6454 (1.2); 0.6317 (1.1); 0.2258 (1.1); 0.2142

(1.5) ; 0.2015 (1.0); -0.0002 (8.5) (1.5); 0.2015 (1.0); -0.0002 (8.5)

1.71-20: 1 H-NMR(400.0 MHz, CDCI3):  1.71-20: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5079 (3.7); 7.5059 (3.7); 7.3679 (0.9); 7.3628 (0.7); 7.3519 (0.5); 7.3468 (1.7); 7.3417 (0.6); 7.3305 (0.7); 7.3257 (1.0); 7.3097 (0.7); 7.2601 (41.1); 7.0153 (2.2); 6.9961 (2.8); 6.9945 (2.4); 6.9753 (1.9); 6.5424 (0.6); 2.4611 (0.7); 2.4508 (1.4); 2.4410 (1.4); 2.4312 (1.4); 2.4209 (0.7); 2.0115 (9.7); 2.0096 (9.7); 1.8719 (15.7); 1.8690 (15.6); 1.5999 (0.5); 1.0605 (16.0); 0.8843 (15.8); 0.6648 (1.1); 0.6511 (1.2); 0.6453 (1.2); 0.6315 (1.1); 0.2267 (1.1); 0.2149δ = 7.5079 (3.7); 7.5059 (3.7); 7.3679 (0.9); 7.3628 (0.7); 7.3519 (0.5); 7.3468 (1.7); 7.3417 (0.6); 7.3305 (0.7); 7.3257 (1.0); 7.3097 (0.7); 7.2601 (41.1); 7.0153 (2.2); 6.9961 (2.8); 6.9945 (2.4); 6.9753 (1.9); 6.5424 (0.6); 2.4611 (0.7); 2.4508 (1.4); 2.4410 (1.4); 2.4312 (1.4); 2.4209 (0.7); 2.0115 (9.7); 2.0096 (9.7); 1.8719 (15.7); 1.8690 (15.6); 1.5999 (0.5); 1.0605 (16.0); 0.8843 (15.8); 0.6648 (1.1); 0.6511 (1.2); 0.6453 (1.2); 0.6315 (1.1); 0.2267 (1.1); 0.2149

(1.4); 0.2023 (1.0); 0.0079 (0.6); -0.0002 (16.8) (1.4); 0.2023 (1.0); 0.0079 (0.6); -0.0002 (16.8)

1.71-21 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-21: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5068 (4.6); 7.5048 (4.5); 7.3918 (0.6); 7.3759 (1.2); 7.3712 (0.8); 7.3599 (0.7); 7.3548 (2.2); 7.3497 (0.8); 7.3383 (0.9); 7.3337 (1.4); 7.3177 (0.8); 7.2598 (75.7); 7.1420 (0.7); 7.0236 (2.7); 7.0166 (0.5); 7.0129 (0.6); 7.0043 (3.1); 7.0027 (2.8); 6.9958 (0.8); 6.9900 (0.5); 6.9860 (1.2); 6.9835 (2.3); 3.3285 (0.6); 3.3235 (0.6); 3.3134 (0.6); 3.3108 (0.6); 3.3007 (0.6); 3.2956 (0.6); 3.2856 (0.6); 2.0229 (11.6); 2.0208 (11.5); 1.8760 (15.7); 1.8634 (16.0); 1.8251 (0.6); 1.7633 (0.6); 1.7474 (0.6); 1.7409 (0.7); 1.7383 (0.6); 1.7303 (0.6); 1.7251 (0.7); 1.7223 (0.7); 1.7145 (0.8); 1.7079 (0.8); 1.7053 (0.7); 1.6999 (0.7); 1.6921 (0.8); 1.6893 (0.7); 1.6829 (0.6); 1.6670 (0.6); 1.5437 (15.1); 1.2949 (0.5); 1.2908 (0.5); 1.2836 (0.5); 1.2799 (0.6); 1.2725 (0.6); 1.2699 (0.7); 1.2586 (0.8); 1.2551 (0.7); 1.2477δ = 7.5068 (4.6); 7.5048 (4.5); 7.3918 (0.6); 7.3759 (1.2); 7.3712 (0.8); 7.3599 (0.7); 7.3548 (2.2); 7.3497 (0.8); 7.3383 (0.9); 7.3337 (1.4); 7.3177 (0.8); 7.2598 (75.7); 7.1420 (0.7); 7.0236 (2.7); 7.0166 (0.5); 7.0129 (0.6); 7.0043 (3.1); 7.0027 (2.8); 6.9958 (0.8); 6.9900 (0.5); 6.9860 (1.2); 6.9835 (2.3); 3.3285 (0.6); 3.3235 (0.6); 3.3134 (0.6); 3.3108 (0.6); 3.3007 (0.6); 3.2956 (0.6); 3.2856 (0.6); 2.0229 (11.6); 2.0208 (11.5); 1.8760 (15.7); 1.8634 (16.0); 1.8251 (0.6); 1.7633 (0.6); 1.7474 (0.6); 1.7409 (0.7); 1.7383 (0.6); 1.7303 (0.6); 1.7251 (0.7); 1.7223 (0.7); 1.7145 (0.8); 1.7079 (0.8); 1.7053 (0.7); 1.6999 (0.7); 1.6921 (0.8); 1.6893 (0.7); 1.6829 (0.6); 1.6670 (0.6); 1.5437 (15.1); 1.2949 (0.5); 1.2908 (0.5); 1.2836 (0.5); 1.2799 (0.6); 1.2725 (0.6); 1.2699 (0.7); 1.2586 (0.8); 1.2551 (0.7); 1.2477

(0.5); 1.2440 (0.6); 1.2367 (0.6); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (1.0) (0.5); 1.2440 (0.6); 1.2367 (0.6); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (1.0)

1.71-22: 1 H-NMR(400.0 MHz, CDCI3):  1.71-22: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4885 (4.6); 7.4865 (4.5); 7.3920 (0.6); 7.3759 (1.2); 7.3705 (0.8); 7.3600 (0.7); 7.3549 (2.1); 7.3498 (0.8); 7.3393 (0.9); 7.3384 (0.9); 7.3338 (1.4); 7.3178 (0.7); 7.2603 (51.5); 7.0237 (2.6); 7.0167 (0.5); 7.0130 (0.6); 7.0043δ = 7.4885 (4.6); 7.4865 (4.5); 7.3920 (0.6); 7.3759 (1.2); 7.3705 (0.8); 7.3600 (0.7); 7.3549 (2.1); 7.3498 (0.8); 7.3393 (0.9); 7.3384 (0.9); 7.3338 (1.4); 7.3178 (0.7); 7.2603 (51.5); 7.0237 (2.6); 7.0167 (0.5); 7.0130 (0.6); 7.0043

(3.1) ; 7.0028 (2.8); 6.9963 (0.7); 6.9944 (0.6); 6.9900 (0.6); 6.9860 (1.2); 6.9835 (2.3); 6.7619 (0.8); 5.2983 (15.9); 3.7813 (1.3); 3.7751 (0.6); 3.7636 (1.4); 3.7573 (2.0); 3.7459 (0.5); 3.7396 (2.0); 3.7219 (0.6); 3.6834 (0.6); 3.6658(3.1); 7.0028 (2.8); 6.9963 (0.7); 6.9944 (0.6); 6.9900 (0.6); 6.9860 (1.2); 6.9835 (2.3); 6.7619 (0.8); 5.2983 (15.9); 3.7813 (1.3); 3.7751 (0.6); 3.7636 (1.4); 3.7573 (2.0); 3.7459 (0.5); 3.7396 (2.0); 3.7219 (0.6); 3.6834 (0.6); 3.6658

(2.2) ; 3.6595 (0.6); 3.6482 (2.3); 3.6418 (1.6); 3.6306 (0.8); 3.6242 (1.5); 3.1367 (0.9); 3.1327 (1.0); 3.1271 (1.1); 3.1231 (1.1); 3.1186 (1.1); 3.1146 (1.2); 3.1090 (1.1); 3.1050 (1.0); 2.6955 (0.5); 2.6915 (0.6); 2.6873 (0.6); 2.6833(2.2); 3.6595 (0.6); 3.6482 (2.3); 3.6418 (1.6); 3.6306 (0.8); 3.6242 (1.5); 3.1367 (0.9); 3.1327 (1.0); 3.1271 (1.1); 3.1231 (1.1); 3.1186 (1.1); 3.1146 (1.2); 3.1090 (1.1); 3.1050 (1.0); 2.6955 (0.5); 2.6915 (0.6); 2.6873 (0.6); 2.6833

(1.1) ; 2.6793 (0.7); 2.6750 (0.8); 2.6734 (0.8); 2.6711 (0.8); 2.6694 (0.8); 2.6651 (0.7); 2.6611 (1.2); 2.6571 (0.7); 2.6529 (0.6); 2.6489 (0.6); 2.0172 (11.0); 2.0151 (11.2); 1.8480 (15.7); 1.8410 (16.0); 1.2076 (7.4); 1.1900 (15.7); 1.1723 (7.4); 1.0826 (1.1); 1.0730 (1.1); 1.0653 (1.3); 1.0604 (1.3); 1.0556 (1.4); 1.0508 (1.2); 1.0430 (1.2); 1.0334(1.1); 2.6793 (0.7); 2.6750 (0.8); 2.6734 (0.8); 2.6711 (0.8); 2.6694 (0.8); 2.6651 (0.7); 2.6611 (1.2); 2.6571 (0.7); 2.6529 (0.6); 2.6489 (0.6); 2.0172 (11.0); 2.0151 (11.2); 1.8480 (15.7); 1.8410 (16.0); 1.2076 (7.4); 1.1900 (15.7); 1.1723 (7.4); 1.0826 (1.1); 1.0730 (1.1); 1.0653 (1.3); 1.0604 (1.3); 1.0556 (1.4); 1.0508 (1.2); 1.0430 (1.2); 1.0334

(1.2) ; 0.7196 (0.9); 0.7073 (1.0); 0.7018 (1.7); 0.6895 (1.7); 0.6841 (0.9); 0.6718 (0.8); 0.0080 (0.6); -0.0002 (22.6); -(1.2); 0.7196 (0.9); 0.7073 (1.0); 0.7018 (1.7); 0.6895 (1.7); 0.6841 (0.9); 0.6718 (0.8); 0.0080 (0.6); -0.0002 (22.6); -

0.0085 (0.9) 0.0085 (0.9)

1.71-23: 1 H-NMR(400.0 MHz, CDCI3):  1.71-23: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5229 (1.7); 7.5210 (1.6); 7.3496 (0.8); 7.2601 (29.4); 7.0172 (1.0); 6.9980 (1.2); 6.9963 (1.2); 6.9775 (0.8); 3.0489 (1.3); 3.0354 (1.4); 3.0313 (1.4); 3.0179 (1.3); 2.1697 (2.2); 2.0310 (4.6); 2.0292 (4.4); 1.8733 (16.0); 1.5501δ = 7.5229 (1.7); 7.5210 (1.6); 7.3496 (0.8); 7.2601 (29.4); 7.0172 (1.0); 6.9980 (1.2); 6.9963 (1.2); 6.9775 (0.8); 3.0489 (1.3); 3.0354 (1.4); 3.0313 (1.4); 3.0179 (1.3); 2.1697 (2.2); 2.0310 (4.6); 2.0292 (4.4); 1.8733 (16.0); 1.5501

(9.4); 0.4404 (0.9); 0.4374 (1.0); 0.4203 (1.0); 0.4172 (0.8); 0.1226 (1.2); 0.1080 (1.1); -0.0002 (10.4) (9.4); 0.4404 (0.9); 0.4374 (1.0); 0.4203 (1.0); 0.4172 (0.8); 0.1226 (1.2); 0.1080 (1.1); -0.0002 (10.4)

1.71-24: 1 H-NMR(400.0 MHz, CDCI3):  1.71-24: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3432 (0.8); 7.3101 (0.7); 7.2891 (0.5); 7.2605 (26.1); 6.9772 (0.9); 6.9584 (1.0); 6.9563 (1.0); 6.9376 (0.8);δ = 7.3432 (0.8); 7.3101 (0.7); 7.2891 (0.5); 7.2605 (26.1); 6.9772 (0.9); 6.9584 (1.0); 6.9563 (1.0); 6.9376 (0.8);

2.1696 (7.7); 1.9929 (2.9); 1.8390 (16.0); 1.5554 (5.4); -0.0002 (10.2) 2.1696 (7.7); 1.9929 (2.9); 1.8390 (16.0); 1.5554 (5.4); -0.0002 (10.2)

1.71-25: 1 H-NMR(400.0 MHz, CDCI3):  1.71-25: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5332 (1.7); 7.5312 (1.6); 7.3454 (0.8); 7.2602 (20.1); 7.0117 (1.0); 6.9926 (1.2); 6.9908 (1.0); 6.9719 (0.9); 3.1900 (2.2); 3.1758 (2.2); 2.0287 (4.5); 2.0268 (4.5); 1.8880 (16.0); 1.5555 (3.5); 0.9194 (0.5); 0.2069 (2.3); 0.2041 (2.1); 0.1955 (1.0); 0.1866 (1.0); 0.1832 (0.9); 0.1724 (0.6); 0.1373 (0.8); 0.1267 (1.4); -0.0002 (7.5); -0.1692 (1.1); -δ = 7.5332 (1.7); 7.5312 (1.6); 7.3454 (0.8); 7.2602 (20.1); 7.0117 (1.0); 6.9926 (1.2); 6.9908 (1.0); 6.9719 (0.9); 3.1900 (2.2); 3.1758 (2.2); 2.0287 (4.5); 2.0268 (4.5); 1.8880 (16.0); 1.5555 (3.5); 0.9194 (0.5); 0.2069 (2.3); 0.2041 (2.1); 0.1955 (1.0); 0.1866 (1.0); 0.1832 (0.9); 0.1724 (0.6); 0.1373 (0.8); 0.1267 (1.4); -0.0002 (7.5); -0.1692 (1.1); -

0.1721 (1.2); -0.1822 (1.1); -0.1852 (1.1) 0.1721 (1.2); -0.1822 (1.1); -0.1852 (1.1)

1.71-26: 1 H-NMR(400.0 MHz, CDCI3):  1.71-26: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5075 (1.7); 7.5056 (1.6); 7.3610 (0.8); 7.2607 (10.0); 7.0365 (1.0); 7.0173 (1.2); 6.9967 (0.9); 2.2696 (0.5);δ = 7.5075 (1.7); 7.5056 (1.6); 7.3610 (0.8); 7.2607 (10.0); 7.0365 (1.0); 7.0173 (1.2); 6.9967 (0.9); 2.2696 (0.5);

2.2472 (0.6); 2.0335 (4.5); 2.0317 (4.4); 1.8450 (16.0); 1.7816 (0.5); 1.6816 (0.6); 1.5704 (1.2); -0.0002 (4.4) 2.2472 (0.6); 2.0335 (4.5); 2.0317 (4.4); 1.8450 (16.0); 1.7816 (0.5); 1.6816 (0.6); 1.5704 (1.2); -0.0002 (4.4)

1.71-27: 1 H-NMR(400.0 MHz, CDCI3):  1.71-27: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5247 (1.8); 7.5228 (1.8); 7.3723 (0.8); 7.2604 (20.9); 7.0365 (1.0); 7.0167 (1.4); 6.9964 (1.0); 2.7556 (0.5); 2.7439 (0.7); 2.7326 (0.5); 2.7231 (0.5); 2.7124 (0.5); 2.2891 (0.5); 2.2861 (0.6); 2.2572 (0.7); 2.0437 (4.6); 2.0418δ = 7.5247 (1.8); 7.5228 (1.8); 7.3723 (0.8); 7.2604 (20.9); 7.0365 (1.0); 7.0167 (1.4); 6.9964 (1.0); 2.7556 (0.5); 2.7439 (0.7); 2.7326 (0.5); 2.7231 (0.5); 2.7124 (0.5); 2.2891 (0.5); 2.2861 (0.6); 2.2572 (0.7); 2.0437 (4.6); 2.0418

(4.6) ; 1.8714 (16.0); 1.5489 (4.3); -0.0002 (7.6) (4.6); 1.8714 (16.0); 1.5489 (4.3); -0.0002 (7.6)

1.71-28: 1 H-NMR(400.0 MHz, CDCI3):  1.71-28: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5289 (1.6); 7.5270 (1.6); 7.3525 (0.8); 7.2594 (20.6); 7.0162 (1.0); 6.9969 (1.2); 6.9954 (1.2); 6.9763 (0.9); 2.5019 (0.7); 2.4874 (0.6); 2.4810 (0.5); 2.4662 (0.5); 2.0331 (4.3); 2.0312 (4.3); 1.9527 (0.6); 1.8593 (16.0); 1.5392 (3.6); -0.0002 (7.5) 1.71-29: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5289 (1.6); 7.5270 (1.6); 7.3525 (0.8); 7.2594 (20.6); 7.0162 (1.0); 6.9969 (1.2); 6.9954 (1.2); 6.9763 (0.9); 2.5019 (0.7); 2.4874 (0.6); 2.4810 (0.5); 2.4662 (0.5); 2.0331 (4.3); 2.0312 (4.3); 1.9527 (0.6); 1.8593 (16.0); 1.5392 (3.6); -0.0002 (7.5) 1.71-29: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5298 (1.9); 7.5279 (1.8); 7.3674 (0.8); 7.3463 (0.6); 7.2605 (19.4); 7.0331 (1.1); 7.0133 (1.4); 6.9929 (1.0); 5.2983 (1.3); 4.3888 (0.5); 3.4235 (0.7); 3.4032 (0.8); 3.3879 (0.6); 3.3719 (1.0); 3.3517 (0.9); 3.0145 (0.9); 2.9993 (1.2); 2.9629 (1.0); 2.9480 (0.7); 2.0396 (4.5); 2.0377 (4.4); 2.0292 (0.6); 2.0272 (0.6); 1.8901 (1.9); 1.8750 (16.0);δ = 7.5298 (1.9); 7.5279 (1.8); 7.3674 (0.8); 7.3463 (0.6); 7.2605 (19.4); 7.0331 (1.1); 7.0133 (1.4); 6.9929 (1.0); 5.2983 (1.3); 4,388 (0.5); 3.4235 (0.7); 3.4032 (0.8); 3.3879 (0.6); 3.3719 (1.0); 3.3517 (0.9); 3.0145 (0.9); 2.9993 (1.2); 2.9629 (1.0); 2.9480 (0.7); 2.0396 (4.5); 2.0377 (4.4); 2.0292 (0.6); 2.0272 (0.6); 1.8901 (1.9); 1.8750 (16.0);

1.5512 (2.5); -0.0002 (8.5) 1.5512 (2.5); -0.0002 (8.5)

1.71-30: 1 H-NMR(400.0 MHz, CDCI3):  1.71-30: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5095 (1.6); 7.5074 (1.9); 7.5050 (2.1); 7.5030 (1.7); 7.3790 (0.6); 7.3622 (0.8); 7.3581 (0.8); 7.3413 (0.7); 7.2598 (37.0); 7.0391 (1.0); 7.0319 (1.0); 7.0198 (1.3); 7.0128 (1.2); 6.9992 (1.0); 6.9954 (0.6); 6.9920 (0.8); 2.4446 (0.6); 2.4376 (0.5); 2.4225 (0.5); 2.4156 (0.6); 2.0323 (8.1); 1.9569 (2.4); 1.9377 (2.9); 1.9218 (1.0); 1.8463 (14.3); 1.8409 (16.0); 1.5517 (6.0); 1.3496 (0.6); 1.3428 (0.6); 1.3267 (0.6); 1.3198 (0.6); 1.1268 (4.5); 1.1092 (4.2); 1.0381δ = 7.5095 (1.6); 7.5074 (1.9); 7.5050 (2.1); 7.5030 (1.7); 7.3790 (0.6); 7.3622 (0.8); 7.3581 (0.8); 7.3413 (0.7); 7.2598 (37.0); 7.0391 (1.0); 7.0319 (1.0); 7.0198 (1.3); 7.0128 (1.2); 6.9992 (1.0); 6.9954 (0.6); 6.9920 (0.8); 2.4446 (0.6); 2.4376 (0.5); 2.4225 (0.5); 2.4156 (0.6); 2.0323 (8.1); 1.9569 (2.4); 1.9377 (2.9); 1.9218 (1.0); 1.8463 (14.3); 1.8409 (16.0); 1.5517 (6.0); 1.3496 (0.6); 1.3428 (0.6); 1.3267 (0.6); 1.3198 (0.6); 1.1268 (4.5); 1.1092 (4.2); 1.0381

(3.7); 1.0216 (3.6); -0.0002 (12.7) (3.7); 1.0216 (3.6); -0.0002 (12.7)

1.71-31 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-31: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4983 (1.8); 7.4965 (1.8); 7.3565 (0.8); 7.2598 (19.9); 7.0305 (1.1); 7.0112 (1.3); 6.9907 (0.9); 4.1104 (0.5); 4.0913 (0.6); 2.3654 (0.6); 2.3465 (0.7); 2.3419 (0.7); 2.3351 (0.8); 2.3162 (0.7); 2.0268 (5.0); 2.0251 (4.9); 2.0174 (0.8); 1.9957 (1.4); 1.9782 (0.7); 1.8819 (1.1); 1.8757 (0.5); 1.8635 (1.0); 1.8522 (0.7); 1.8356 (16.0); 1.8253 (0.6); 1.8226 (0.6); 1.8073 (0.6); 1.8018 (1.0); 1.7844 (1.2); 1.7289 (0.6); 1.7069 (0.9); 1.6992 (0.8); 1.6772 (0.6); 1.5508δ = 7.4983 (1.8); 7.4965 (1.8); 7.3565 (0.8); 7.2598 (19.9); 7.0305 (1.1); 7.0112 (1.3); 6.9907 (0.9); 4.1104 (0.5); 4.0913 (0.6); 2.3654 (0.6); 2.3465 (0.7); 2.3419 (0.7); 2.3351 (0.8); 2.3162 (0.7); 2.0268 (5.0); 2.0251 (4.9); 2.0174 (0.8); 1.9957 (1.4); 1.9782 (0.7); 1.8819 (1.1); 1.8757 (0.5); 1.8635 (1.0); 1.8522 (0.7); 1.8356 (16.0); 1.8253 (0.6); 1.8226 (0.6); 1.8073 (0.6); 1.8018 (1.0); 1.7844 (1.2); 1.7289 (0.6); 1.7069 (0.9); 1.6992 (0.8); 1.6772 (0.6); 1.5508

(2.6) ; -0.0002 (7.4) (2.6); -0.0002 (7.4)

1.71-32: 1 H-NMR(400.0 MHz, CDCI3):  1.71-32: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.5210 (3.4); 7.5090 (3.7); 7.3789 (1.7); 7.3578 (2.4); 7.3423 (1.8); 7.2618 (46.6); 7.2597 (51.1); 7.0327 (3.5); 7.0140 (5.3); 6.9953 (3.3); 6.7827 (1.0); 6.6531 (0.7); 4.3431 (0.9); 4.3218 (0.7); 3.8320 (1.0); 3.8115 (1.3); 3.7915δ = 7.5210 (3.4); 7.5090 (3.7); 7.3789 (1.7); 7.3578 (2.4); 7.3423 (1.8); 7.2618 (46.6); 7.2597 (51.1); 7.0327 (3.5); 7.0140 (5.3); 6.9953 (3.3); 6.7827 (1.0); 6.6531 (0.7); 4.3431 (0.9); 4.3218 (0.7); 3.8320 (1.0); 3.8115 (1.3); 3.7915

(1.0) ; 2.5720 (0.7); 2.1852 (1.2); 2.1626 (1.3); 2.1424 (1.2); 2.0316 (16.0); 1.8713 (14.6); 1.8644 (15.1); 1.8567 (15.4); 1.8447 (13.4); 1.5420 (9.9); 1.3178 (1.1); 1.2549 (1.5); 1.2293 (1.4); 1.2048 (1.0); 1.0605 (6.1); 1.0442 (5.8);(1.0); 2.5720 (0.7); 2.1852 (1.2); 2.1626 (1.3); 2.1424 (1.2); 2.0316 (16.0); 1.8713 (14.6); 1.8644 (15.1); 1.8567 (15.4); 1.8447 (13.4); 1.5420 (9.9); 1.3178 (1.1); 1.2549 (1.5); 1.2293 (1.4); 1.2048 (1.0); 1.0605 (6.1); 1.0442 (5.8);

0.8493 (4.0); 0.8325 (3.9); -0.0002 (18.5) 0.8493 (4.0); 0.8325 (3.9); -0.0002 (18.5)

1.71-33: 1 H-NMR(400.0 MHz, CDCI3):  1.71-33: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3205 (0.5); 7.2603 (23.1); 6.9898 (0.6); 6.9708 (0.8); 6.9514 (0.5); 2.0502 (0.5); 1.9743 (2.1); 1.8449 (0.6);δ = 7.3205 (0.5); 7.2603 (23.1); 6.9898 (0.6); 6.9708 (0.8); 6.9514 (0.5); 2.0502 (0.5); 1.9743 (2.1); 1.8449 (0.6);

1.8221 (16.0); 1.5503 (3.6); 1.2649 (0.8); 0.8819 (1.5); 0.8641 (0.6); -0.0002 (13.2); -0.0085 (0.5) 1.8221 (16.0); 1.5503 (3.6); 1.2649 (0.8); 0.8819 (1.5); 0.8641 (0.6); -0.0002 (13.2); -0.0085 (0.5)

1.71-34: 1 H-NMR(400.0 MHz, CDCI3):  1.71-34: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5231 (1.8); 7.5211 (1.9); 7.3737 (0.8); 7.3527 (0.5); 7.2599 (30.7); 7.0487 (1.0); 7.0292 (1.2); 7.0086 (0.9); 4.9416 (0.6); 4.8590 (1.2); 4.8421 (1.8); 4.8240 (0.9); 4.4569 (1.2); 4.4397 (1.9); 4.4238 (1.1); 2.1697 (2.0); 2.0462δ = 7.5231 (1.8); 7.5211 (1.9); 7.3737 (0.8); 7.3527 (0.5); 7.2599 (30.7); 7.0487 (1.0); 7.0292 (1.2); 7.0086 (0.9); 4.9416 (0.6); 4.8590 (1.2); 4.8421 (1.8); 4.8240 (0.9); 4.4569 (1.2); 4.4397 (1.9); 4.4238 (1.1); 2.1697 (2.0); 2.0462

(4.4); 2.0443 (4.4); 1.8595 (16.0); 1.5455 (6.0); -0.0002 (11.7) (4.4); 2.0443 (4.4); 1.8595 (16.0); 1.5455 (6.0); -0.0002 (11.7)

1.71-35: 1 H-NMR(400.0 MHz, CDCI3):  1.71-35: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9301 (0.6); 7.5524 (1.9); 7.5505 (1.8); 7.3631 (0.8); 7.3420 (0.5); 7.2594 (57.7); 7.0290 (1.1); 7.0093 (1.5); 6.9954 (0.5); 6.9888 (1.0); 5.0141 (2.4); 4.9970 (2.6); 4.5944 (2.5); 4.5773 (2.3); 3.7972 (12.2); 2.0560 (4.9); 2.0542δ = 7.9301 (0.6); 7.5524 (1.9); 7.5505 (1.8); 7.3631 (0.8); 7.3420 (0.5); 7.2594 (57.7); 7.0290 (1.1); 7.0093 (1.5); 6.9954 (0.5); 6,988 (1.0); 5.0141 (2.4); 4.9970 (2.6); 4.5944 (2.5); 4.5773 (2.3); 3.7972 (12.2); 2.0560 (4.9); 2.0542

(4.7) ; 1.8928 (0.5); 1.8764 (16.0); 1.5346 (6.0); 0.0080 (0.7); -0.0002 (20.8); -0.0085 (0.7) (4.7); 1.8928 (0.5); 1.8764 (16.0); 1.5346 (6.0); 0.0080 (0.7); -0.0002 (20.8); -0.0085 (0.7)

1.71-36: 1 H-NMR(400.0 MHz, CDCI3):  1.71-36: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5072 (1.7); 7.5055 (1.8); 7.3493 (0.8); 7.2603 (19.2); 7.0193 (1.0); 7.0002 (1.3); 6.9796 (0.9); 4.0824 (0.5); 4.0649 (0.5); 2.0196 (4.8); 2.0182 (5.0); 1.9019 (0.5); 1.8841 (0.6); 1.8692 (0.5); 1.8521 (16.0); 1.6002 (0.6); 1.5826δ = 7.5072 (1.7); 7.5055 (1.8); 7.3493 (0.8); 7.2603 (19.2); 7.0193 (1.0); 7,0002 (1.3); 6.9796 (0.9); 4.0824 (0.5); 4.0649 (0.5); 2.0196 (4.8); 2.0182 (5.0); 1.9019 (0.5); 1.8841 (0.6); 1.8692 (0.5); 1.8521 (16.0); 1.6002 (0.6); 1.5826

(0.5); 1.5569 (5.8); 1.5434 (0.6); 1.5236 (0.5); 1.2871 (0.5); 1.2716 (0.5); -0.0002 (6.8) (0.5); 1.5569 (5.8); 1.5434 (0.6); 1.5236 (0.5); 1.2871 (0.5); 1.2716 (0.5); -0.0002 (6.8)

1.71-37: 1 H-NMR(400.0 MHz, CDCI3):  1.71-37: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5020 (1.8); 7.5001 (1.8); 7.3372 (0.8); 7.3162 (0.5); 7.2599 (33.4); 7.0030 (1.1); 6.9840 (1.2); 6.9822 (1.1); 6.9633 (0.9); 5.8934 (0.5); 5.8843 (0.5); 5.8794 (0.6); 5.6097 (0.6); 5.6043 (0.6); 5.5956 (0.5); 5.5903 (0.5); 2.2818 (0.6); 2.2774 (0.9); 2.2577 (0.5); 2.1697 (3.4); 2.0126 (4.8); 2.0107 (4.8); 1.8587 (16.0); 1.5476 (9.9); -0.0002 (12.3) 1.71-38: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5020 (1.8); 7,5001 (1.8); 7.3372 (0.8); 7.3162 (0.5); 7.2599 (33.4); 7.0030 (1.1); 6.9840 (1.2); 6.9822 (1.1); 6.9633 (0.9); 5.8934 (0.5); 5.8843 (0.5); 5.8794 (0.6); 5.6097 (0.6); 5.6043 (0.6); 5.5956 (0.5); 5.5903 (0.5); 2.2818 (0.6); 2.2774 (0.9); 2.2577 (0.5); 2.1697 (3.4); 2.0126 (4.8); 2.0107 (4.8); 1.8587 (16.0); 1.5476 (9.9); -0.0002 (12.3) 1.71-38: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5067 (1.8); 7.5048 (1.8); 7.3530 (0.8); 7.3319 (0.5); 7.2601 (33.2); 7.0229 (1.1); 7.0037 (1.3); 6.9831 (1.0); 3.9028 (0.8); 3.8878 (0.8); 3.8795 (0.9); 3.8644 (0.8); 3.8119 (0.8); 3.7720 (0.5); 3.7659 (0.6); 3.7515 (0.6); 3.5139 (0.6); 3.5043 (0.6); 3.4905 (0.6); 3.4809 (0.6); 2.1697 (2.4); 2.0220 (4.8); 2.0203 (4.8); 1.8547 (16.0); 1.5499 (10.4); -δ = 7.5067 (1.8); 7.5048 (1.8); 7.3530 (0.8); 7.3319 (0.5); 7.2601 (33.2); 7.0229 (1.1); 7.0037 (1.3); 6.9831 (1.0); 3.9028 (0.8); 3.8878 (0.8); 3.8795 (0.9); 3.8644 (0.8); 3.8119 (0.8); 3.7720 (0.5); 3.7659 (0.6); 3.7515 (0.6); 3.5139 (0.6); 3.5043 (0.6); 3.4905 (0.6); 3.4809 (0.6); 2.1697 (2.4); 2.0220 (4.8); 2.0203 (4.8); 1.8547 (16.0); 1.5499 (10.4); -

0.0002 (11.6) 0.0002 (11.6)

1.71-39: 1 H-NMR(400.0 MHz, CDCI3):  1.71-39: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5338 (4.0); 7.3851 (0.6); 7.3644 (1.0); 7.3479 (1.8); 7.3278 (1.3); 7.3108 (1.1); 7.2603 (36.0); 7.0159 (2.3); 6.9967 (3.5); 6.9769 (2.0); 4.5444 (0.6); 4.5223 (1.0); 4.4976 (1.1); 4.4757 (0.8); 4.4610 (0.9); 4.4385 (1.7); 4.4155δ = 7.5338 (4.0); 7.3851 (0.6); 7.3644 (1.0); 7.3479 (1.8); 7.3278 (1.3); 7.3108 (1.1); 7.2603 (36.0); 7.0159 (2.3); 6.9967 (3.5); 6.9769 (2.0); 4.5444 (0.6); 4.5223 (1.0); 4.4976 (1.1); 4.4757 (0.8); 4.4610 (0.9); 4.4385 (1.7); 4.4155

(1.1) ; 4.2666 (0.8); 4.2509 (0.9); 4.2414 (1.0); 4.2259 (1.0); 4.2164 (0.8); 4.2010 (0.7); 2.6409 (0.7); 2.6248 (0.8); 2.6096 (0.8); 2.5914 (0.5); 2.1789 (1.0); 2.1694 (1.5); 2.1522 (1.1); 2.1254 (0.8); 2.0286 (11.1); 1.9039 (12.7); 1.8807(1.1); 4.2666 (0.8); 4.2509 (0.9); 4.2414 (1.0); 4.2259 (1.0); 4.2164 (0.8); 4.2010 (0.7); 2.6409 (0.7); 2.6248 (0.8); 2.6096 (0.8); 2.5914 (0.5); 2.1789 (1.0); 2.1694 (1.5); 2.1522 (1.1); 2.1254 (0.8); 2.0286 (11.1); 1.9039 (12.7); 1.8807

(13.0); 1.5486 (16.0); -0.0002 (12.6) (13.0); 1.5486 (16.0); -0.0002 (12.6)

1.71-40: 1 H-NMR(400.0 MHz, CDCI3):  1.71-40: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5009 (2.6); 7.4996 (2.6); 7.3685 (0.6); 7.3634 (0.6); 7.3474 (1.2); 7.3315 (0.5); 7.3265 (0.7); 7.2601 (36.4); 7.0165 (1.6); 6.9965 (2.1); 6.9769 (1.4); 5.2983 (0.6); 4.4896 (1.0); 4.4761 (1.1); 4.4675 (1.1); 4.4539 (1.2); 4.4365 (0.5); 4.4193 (0.5); 4.0762 (1.0); 4.0608 (1.0); 4.0531 (1.3); 4.0377 (1.1); 3.7707 (1.0); 3.7594 (1.0); 3.7476 (0.9); 3.7362 (0.8); 3.6574 (16.0); 2.5880 (0.5); 2.5689 (0.6); 2.5662 (0.6); 2.5542 (0.6); 2.5471 (0.5); 2.5350 (0.6); 2.5323 (0.6); 2.5132 (0.5); 2.0258 (7.3); 1.9431 (0.8); 1.9092 (0.7); 1.8430 (10.0); 1.8313 (10.0); 1.5468 (7.2); -0.0002 (12.9) 1.71-45: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5009 (2.6); 7.4996 (2.6); 7.3685 (0.6); 7.3634 (0.6); 7.3474 (1.2); 7.3315 (0.5); 7.3265 (0.7); 7.2601 (36.4); 7.0165 (1.6); 6.9965 (2.1); 6.9769 (1.4); 5.2983 (0.6); 4.4896 (1.0); 4.4761 (1.1); 4.4675 (1.1); 4.4539 (1.2); 4.4365 (0.5); 4.4193 (0.5); 4.0762 (1.0); 4.0608 (1.0); 4.0531 (1.3); 4.0377 (1.1); 3.7707 (1.0); 3.7594 (1.0); 3.7476 (0.9); 3.7362 (0.8); 3.6574 (16.0); 2.5880 (0.5); 2.5689 (0.6); 2.5662 (0.6); 2.5542 (0.6); 2.5471 (0.5); 2.5350 (0.6); 2.5323 (0.6); 2.5132 (0.5); 2.0258 (7.3); 1.9431 (0.8); 1.9092 (0.7); 1.8430 (10.0); 1.8313 (10.0); 1.5468 (7.2); -0.0002 (12.9) 1.71-45: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.8744 (1.2); 7.5211 (3.9); 7.5191 (4.2); 7.3972 (0.9); 7.3924 (0.8); 7.3811 (0.6); 7.3762 (1.8); 7.3712 (0.7); 7.3603 (0.8); 7.3550 (1.2); 7.3390 (0.6); 7.2601 (57.0); 7.0397 (2.4); 7.0198 (3.2); 7.0104 (0.6); 6.9993 (2.2); 5.2984 (1.1); 4.2944 (3.0); 4.2700 (3.5); 4.0209 (0.5); 4.0058 (0.6); 3.9986 (1.1); 3.9833 (1.2); 3.9789 (1.2); 3.9637 (1.0); 3.9407 (1.1); 3.9347 (3.0); 3.9240 (1.5); 3.9224 (1.4); 3.9184 (0.8); 3.9103 (2.7); 3.9059 (1.4); 3.9018 (1.0); 3.8834 (0.7); 2.6818 (0.7); 2.6655 (0.8); 2.6623 (0.8); 2.6483 (1.0); 2.6320 (1.0); 2.6288 (1.0); 2.6124 (0.9); 2.3162 (0.7); 2.3008 (0.8); 2.2977 (0.9); 2.2826 (1.3); 2.2673 (0.7); 2.2643 (0.7); 2.2490 (0.6); 2.0363 (9.8); 2.0343 (9.8); 1.8750 (15.9); 1.8717 (16.0); 1.5490 (2.7); 0.0079 (0.6); -0.0002 (20.0); -0.0085 (0.8) 1.71-46: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.8744 (1.2); 7.5211 (3.9); 7.5191 (4.2); 7.3972 (0.9); 7.3924 (0.8); 7.3811 (0.6); 7.3762 (1.8); 7.3712 (0.7); 7.3603 (0.8); 7.3550 (1.2); 7.3390 (0.6); 7.2601 (57.0); 7.0397 (2.4); 7.0198 (3.2); 7.0104 (0.6); 6.9993 (2.2); 5.2984 (1.1); 4.2944 (3.0); 4.2700 (3.5); 4.0209 (0.5); 4.0058 (0.6); 3.9986 (1.1); 3.9833 (1.2); 3.9789 (1.2); 3.9637 (1.0); 3.9407 (1.1); 3.9347 (3.0); 3.9240 (1.5); 3.9224 (1.4); 3.9184 (0.8); 3.9103 (2.7); 3.9059 (1.4); 3.9018 (1.0); 3.8834 (0.7); 2.6818 (0.7); 2.6655 (0.8); 2.6623 (0.8); 2.6483 (1.0); 2.6320 (1.0); 2.6288 (1.0); 2.6124 (0.9); 2.3162 (0.7); 2.3008 (0.8); 2.2977 (0.9); 2.2826 (1.3); 2.2673 (0.7); 2.2643 (0.7); 2.2490 (0.6); 2.0363 (9.8); 2.0343 (9.8); 1.8750 (15.9); 1.8717 (16.0); 1.5490 (2.7); 0.0079 (0.6); -0.0002 (20.0); -0.0085 (0.8) 1.71-46: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7681 (0.6); 7.5264 (1.9); 7.5244 (1.9); 7.3731 (0.9); 7.3521 (0.5); 7.2600 (31.7); 7.0342 (1.1); 7.0144 (1.5); 6.9940 (1.0); 3.4759 (1.4); 3.4466 (1.7); 3.1626 (1.5); 3.1333 (1.2); 3.0573 (0.7); 3.0299 (0.9); 2.8672 (0.8); 2.8398 (0.6); 2.5151 (1.3); 2.4979 (2.2); 2.4806 (1.0); 2.0324 (4.8); 2.0306 (4.9); 1.8784 (16.0); 1.8248 (1.1); 1.5459 (2.2); -δ = 7.7681 (0.6); 7.5264 (1.9); 7.5244 (1.9); 7.3731 (0.9); 7.3521 (0.5); 7.2600 (31.7); 7.0342 (1.1); 7.0144 (1.5); 6.9940 (1.0); 3.4759 (1.4); 3.4466 (1.7); 3.1626 (1.5); 3.1333 (1.2); 3.0573 (0.7); 3.0299 (0.9); 2.8672 (0.8); 2.8398 (0.6); 2.5151 (1.3); 2.4979 (2.2); 2.4806 (1.0); 2.0324 (4.8); 2.0306 (4.9); 1.8784 (16.0); 1.8248 (1.1); 1.5459 (2.2); -

0.0002 (11.4) 0.0002 (11.4)

1.71-47: 1 H-NMR(400.0 MHz, CDCI3):  1.71-47: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5245 (4.3); 7.5228 (4.2); 7.3338 (0.6); 7.3179 (1.1); 7.3129 (1.0); 7.3019 (0.6); 7.2969 (2.0); 7.2916 (0.7); 7.2810 (1.0); 7.2758 (1.4); 7.2585 (71.8); 7.1957 (3.0); 7.1883 (3.4); 7.1788 (2.0); 7.1350 (3.8); 7.1263 (3.6); 7.1213δ = 7.5245 (4.3); 7.5228 (4.2); 7.3338 (0.6); 7.3179 (1.1); 7.3129 (1.0); 7.3019 (0.6); 7.2969 (2.0); 7.2916 (0.7); 7.2810 (1.0); 7.2758 (1.4); 7.2585 (71.8); 7.1957 (3.0); 7.1883 (3.4); 7.1788 (2.0); 7.1350 (3.8); 7.1263 (3.6); 7.1213

(2.2) ; 6.9420 (2.6); 6.9231 (3.0); 6.9026 (2.3); 6.7513 (0.6); 6.7327 (0.6); 5.3907 (0.6); 5.3709 (1.7); 5.3512 (1.7); 5.3311 (0.6); 2.9575 (0.5); 2.9438 (0.5); 2.9355 (0.5); 2.9263 (1.0); 2.9179 (1.0); 2.9042 (1.0); 2.8958 (1.0); 2.8590 (0.7); 2.8380 (1.4); 2.8176 (1.0); 2.7984 (0.7); 2.5568 (0.5); 2.5375 (0.9); 2.5290 (0.9); 2.5249 (0.6); 2.5174 (0.8);(2.2); 6.9420 (2.6); 6.9231 (3.0); 6.9026 (2.3); 6.7513 (0.6); 6.7327 (0.6); 5.3907 (0.6); 5.3709 (1.7); 5.3512 (1.7); 5.3311 (0.6); 2.9575 (0.5); 2.9438 (0.5); 2.9355 (0.5); 2.9263 (1.0); 2.9179 (1.0); 2.9042 (1.0); 2.8958 (1.0); 2.8590 (0.7); 2.8380 (1.4); 2.8176 (1.0); 2.7984 (0.7); 2.5568 (0.5); 2.5375 (0.9); 2.5290 (0.9); 2.5249 (0.6); 2.5174 (0.8);

2.5095 (0.5); 2.5054 (1.0); 2.4970 (0.9); 1.9896 (11.9); 1.9883 (11.8); 1.9295 (16.0); 1.9095 (16.0); 1.8250 (0.6);2.5095 (0.5); 2.5054 (1.0); 2.4970 (0.9); 1.9896 (11.9); 1.9883 (11.8); 1.9295 (16.0); 1.9095 (16.0); 1.8250 (0.6);

1.7145 (1.0); 1.6939 (1.0); 1.6824 (1.0); 1.6619 (1.0); 1.5401 (6.9); 0.0080 (0.9); -0.0002 (25.9); -0.0084 (0.8) 1.7145 (1.0); 1.6939 (1.0); 1.6824 (1.0); 1.6619 (1.0); 1.5401 (6.9); 0.0080 (0.9); -0.0002 (25.9); -0.0084 (0.8)

1.71-48: 1 H-NMR(400.0 MHz, CDCI3):  1.71-48: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5253 (1.8); 7.5233 (1.8); 7.3655 (0.8); 7.2605 (15.4); 7.2098 (0.6); 7.0269 (1.1); 7.0076 (1.3); 6.9870 (1.0);δ = 7.5253 (1.8); 7.5233 (1.8); 7.3655 (0.8); 7.2605 (15.4); 7.2098 (0.6); 7.0269 (1.1); 7.0076 (1.3); 6,99870 (1.0);

2.0260 (4.6); 2.0242 (4.7); 1.8722 (16.0); 1.6398 (1.0); 1.6192 (2.6); 1.5931 (0.6); 1.5511 (1.3); -0.0002 (7.5) 2.0260 (4.6); 2.0242 (4.7); 1.8722 (16.0); 1.6398 (1.0); 1.6192 (2.6); 1.5931 (0.6); 1.5511 (1.3); -0.0002 (7.5)

1.71-49: 1 H-NMR(400.0 MHz, CDCI3):  1.71-49: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4971 (1.9); 7.4952 (1.9); 7.3506 (0.8); 7.3296 (0.5); 7.2600 (34.4); 7.0230 (1.1); 7.0039 (1.3); 6.9833 (1.0); 4.1221 (0.9); 4.1043 (2.9); 4.0865 (2.9); 4.0687 (1.0); 2.0221 (5.0); 2.0205 (5.0); 1.8491 (16.0); 1.8097 (0.7); 1.8028δ = 7.4971 (1.9); 7.4952 (1.9); 7.3506 (0.8); 7.3296 (0.5); 7.2600 (34.4); 7.0230 (1.1); 7.0039 (1.3); 6.9833 (1.0); 4.1221 (0.9); 4.1043 (2.9); 4.0865 (2.9); 4.0687 (1.0); 2.0221 (5.0); 2.0205 (5.0); 1.8491 (16.0); 1.8097 (0.7); 1.8028

(0.6); 1.5449 (4.6); 1.2488 (3.2); 1.2309 (6.6); 1.2131 (3.1); 1.1599 (0.7); 1.1295 (0.7); -0.0002 (12.9) (0.6); 1.5449 (4.6); 1.2488 (3.2); 1.2309 (6.6); 1.2131 (3.1); 1.1599 (0.7); 1.1295 (0.7); -0.0002 (12.9)

1.71-50: 1 H-NMR(400.0 MHz, CDCI3):  1.71-50: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5104 (1.8); 7.5084 (1.8); 7.5011 (0.5); 7.3584 (0.5); 7.3424 (0.9); 7.3213 (0.6); 7.2605 (29.4); 7.0053 (1.3); 6.9863 (1.4); 6.9656 (0.9); 5.2985 (0.7); 3.6618 (11.0); 3.6562 (2.9); 2.0202 (5.8); 2.0185 (5.7); 1.8527 (16.0); 1.8476 (4.8); 1.6683 (0.5); 1.6573 (0.7); 1.6470 (0.8); 1.6391 (0.8); 1.6263 (0.8); 1.6207 (0.8); 1.6103 (0.8); 1.6007 (0.6);δ = 7.5104 (1.8); 7.5084 (1.8); 7.5011 (0.5); 7.3584 (0.5); 7.3424 (0.9); 7.3213 (0.6); 7.2605 (29.4); 7.0053 (1.3); 6.9863 (1.4); 6.9656 (0.9); 5.2985 (0.7); 3.6618 (11.0); 3.6562 (2.9); 2.0202 (5.8); 2.0185 (5.7); 1.8527 (16.0); 1.8476 (4.8); 1.6683 (0.5); 1.6573 (0.7); 1.6470 (0.8); 1.6391 (0.8); 1.6263 (0.8); 1.6207 (0.8); 1.6103 (0.8); 1.6007 (0.6);

1.5563 (3.5); 1.4625 (0.5); -0.0002 (11.2) 1.5563 (3.5); 1.4625 (0.5); -0.0002 (11.2)

1.71-51 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-51: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.7944 (2.9); 7.8424 (6.2); 7.8404 (6.1); 7.6965 (2.1); 7.6767 (2.2); 7.5445 (0.7); 7.5281 (1.4); 7.5233 (1.1); 7.5117 (0.9); 7.5070 (2.5); 7.5024 (0.9); 7.4905 (1.1); 7.4860 (1.5); 7.4696 (0.7); 7.2205 (0.6); 7.2099 (3.6); 7.2034 (0.7); 7.1997 (0.7); 7.1898 (5.1); 7.1799 (0.7); 7.1696 (3.0); 5.7529 (2.2); 4.5402 (0.7); 4.5261 (1.0); 4.5206 (0.8);δ = 10.7944 (2.9); 7.8424 (6.2); 7.8404 (6.1); 7.6965 (2.1); 7.6767 (2.2); 7.5445 (0.7); 7.5281 (1.4); 7.5233 (1.1); 7.5117 (0.9); 7.5070 (2.5); 7.5024 (0.9); 7.4905 (1.1); 7.4860 (1.5); 7.4696 (0.7); 7.2205 (0.6); 7.2099 (3.6); 7.2034 (0.7); 7.1997 (0.7); 7.1898 (5.1); 7.1799 (0.7); 7.1696 (3.0); 5.7529 (2.2); 4.5402 (0.7); 4.5261 (1.0); 4.5206 (0.8);

4.5096 (1.0); 4.5067 (1.2); 4.4960 (0.8); 4.4903 (0.8); 4.4762 (0.8); 4.0384 (0.5); 4.0206 (0.5); 3.3124 (101.8); 2.7398 (0.7); 2.7222 (0.6); 2.7107 (0.9); 2.7077 (0.9); 2.6965 (0.9); 2.6786 (1.0); 2.6699 (0.7); 2.6648 (1.0); 2.5234 (1.6); 2.5187 (2.2); 2.5100 (27.3); 2.5054 (59.6); 2.5008 (83.7); 2.4962 (59.5); 2.4916 (27.4); 2.4804 (1.2); 2.4526 (0.8); 2.4456 (1.0); 2.4358 (0.6); 2.3276 (0.5); 1.9879 (2.5); 1.9620 (1.0); 1.9513 (1.0); 1.9271 (15.7); 1.8989 (1.1); 1.88924.5096 (1.0); 4.5067 (1.2); 4.4960 (0.8); 4.4903 (0.8); 4.4762 (0.8); 4.0384 (0.5); 4.0206 (0.5); 3.3124 (101.8); 2.7398 (0.7); 2.7222 (0.6); 2.7107 (0.9); 2.7077 (0.9); 2.6965 (0.9); 2.6786 (1.0); 2.6699 (0.7); 2.6648 (1.0); 2.5234 (1.6); 2.5187 (2.2); 2.5100 (27.3); 2.5054 (59.6); 2,5008 (83.7); 2.4962 (59.5); 2.4916 (27.4); 2.4804 (1.2); 2.4526 (0.8); 2.4456 (1.0); 2.4358 (0.6); 2.3276 (0.5); 1.9879 (2.5); 1.9620 (1.0); 1.9513 (1.0); 1.9271 (15.7); 1.8989 (1.1); 1.8892

(1.1) ; 1.8841 (1.3); 1.8766 (1.2); 1.8693 (0.8); 1.8617 (0.8); 1.8519 (0.6); 1.8447 (0.5); 1.7414 (16.0); 1.7288 (16.0); 1.7037 (1.8); 1.6954 (0.8); 1.6792 (0.7); 1.6424 (0.8); 1.5670 (0.7); 1.2363 (1.6); 1.1925 (0.8); 1.1747 (1.5); 1.1569(1.1); 1.8841 (1.3); 1.8766 (1.2); 1.8693 (0.8); 1.8617 (0.8); 1.8519 (0.6); 1.8447 (0.5); 1.7414 (16.0); 1.7288 (16.0); 1.7037 (1.8); 1.6954 (0.8); 1.6792 (0.7); 1.6424 (0.8); 1.5670 (0.7); 1.2363 (1.6); 1.1925 (0.8); 1.1747 (1.5); 1.1569

(0.7); 0.0080 (1.3); 0.0046 (0.6); -0.0002 (41.8); -0.0085 (1.2) (0.7); 0.0080 (1.3); 0.0046 (0.6); -0.0002 (41.8); -0.0085 (1.2)

1.71-52: 1 H-NMR(400.0 MHz, CDCI3):  1.71-52: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5398 (4.3); 7.5378 (4.2); 7.3631 (0.5); 7.3472 (1.1); 7.3424 (0.8); 7.3313 (0.6); 7.3262 (2.0); 7.3211 (0.7); 7.3103 (0.9); 7.3051 (1.3); 7.2892 (0.6); 7.2605 (71.2); 6.9967 (2.9); 6.9777 (2.9); 6.9759 (2.7); 6.9570 (2.3); 6.9322 (0.7); 6.9156 (0.7); 5.9961 (0.8); 5.2983 (3.3); 4.2740 (0.5); 4.2579 (0.9); 4.2448 (0.7); 4.2292 (0.9); 4.2131 (0.5); 3.3389 (0.6); 3.3329 (0.9); 3.3183 (1.5); 3.3041 (1.4); 3.2985 (1.2); 2.3197 (0.6); 2.3050 (0.6); 2.2870 (0.7); 2.2732 (0.6); 2.0188 (11.1); 2.0169 (11.0); 1.9137 (0.7); 1.8990 (15.3); 1.8876 (1.5); 1.8766 (16.0); 1.8667 (1.1); 1.8611 (0.7); 1.8557 (0.6); 1.6351 (0.6); 1.6310 (0.5); 1.6222 (0.6); 1.6031 (0.6); 1.5903 (0.5); 1.2550 (0.6); 0.0080 (0.7); -δ = 7.5398 (4.3); 7.5378 (4.2); 7.3631 (0.5); 7.3472 (1.1); 7.3424 (0.8); 7.3313 (0.6); 7.3262 (2.0); 7.3211 (0.7); 7.3103 (0.9); 7.3051 (1.3); 7.2892 (0.6); 7.2605 (71.2); 6.9967 (2.9); 6.9777 (2.9); 6.9759 (2.7); 6.9570 (2.3); 6.9322 (0.7); 6.9156 (0.7); 5.9961 (0.8); 5.2983 (3.3); 4.2740 (0.5); 4.2579 (0.9); 4.2448 (0.7); 4.2292 (0.9); 4.2131 (0.5); 3.3389 (0.6); 3.3329 (0.9); 3.3183 (1.5); 3.3041 (1.4); 3.2985 (1.2); 2.3197 (0.6); 2.3050 (0.6); 2.2870 (0.7); 2.2732 (0.6); 2.0188 (11.1); 2.0169 (11.0); 1.9137 (0.7); 1.8990 (15.3); 1.8876 (1.5); 1.8766 (16.0); 1.8667 (1.1); 1.8611 (0.7); 1.8557 (0.6); 1.6351 (0.6); 1.6310 (0.5); 1.6222 (0.6); 1.6031 (0.6); 1.5903 (0.5); 1.2550 (0.6); 0.0080 (0.7); -

0.0002 (25.5); -0.0085 (0.7) 0.0002 (25.5); -0.0085 (0.7)

1.7-152: 1 H-NMR(400.0 MHz, CDCI3):  1.7-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5060 (0.6); 8.5031 (0.6); 8.4942 (0.6); 8.4913 (0.6); 7.5701 (0.5); 7.5680 (0.5); 7.5510 (0.6); 7.5489 (0.6); 7.5268 (1.8); 7.5208 (1.9); 7.2621 (11.4); 7.1541 (0.7); 7.1423 (0.7); 7.1349 (0.6); 7.1231 (0.6); 6.9809 (1.3); 6.9749δ = 8.5060 (0.6); 8.5031 (0.6); 8.4942 (0.6); 8.4913 (0.6); 7.5701 (0.5); 7.5680 (0.5); 7.5510 (0.6); 7.5489 (0.6); 7.5268 (1.8); 7.5208 (1.9); 7.2621 (11.4); 7.1541 (0.7); 7.1423 (0.7); 7.1349 (0.6); 7.1231 (0.6); 6.9809 (1.3); 6.9749

(1.3) ; 5.2981 (4.2); 2.6239 (6.0); 1.8586 (16.0); 1.8411 (0.7); -0.0002 (4.0) (1.3); 5.2981 (4.2); 2.6239 (6.0); 1.8586 (16.0); 1.8411 (0.7); -0.0002 (4.0)

1.71-53: 1 H-NMR(400.0 MHz, CDCI3):  1.71-53: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9801 (1.3); 7.5143 (2.3); 7.3736 (0.9); 7.3525 (0.5); 7.2598 (107.1); 7.0343 (1.4); 7.0145 (2.1); 6.9956 (1.6); 3.7194 (0.9); 3.6886 (1.0); 3.1356 (0.7); 3.1018 (1.2); 3.0743 (0.7); 2.8503 (7.6); 2.7007 (1.1); 2.6685 (1.2); 2.1972 (0.6); 2.1705 (0.9); 2.1631 (0.9); 2.0947 (0.6); 2.0378 (6.7); 1.8932 (1.0); 1.8650 (16.0); 1.2569 (1.2); 0.0080 (1.2); -δ = 7.9801 (1.3); 7.5143 (2.3); 7.3736 (0.9); 7.3525 (0.5); 7.2598 (107.1); 7.0343 (1.4); 7.0145 (2.1); 6.9956 (1.6); 3.7194 (0.9); 3.6886 (1.0); 3.1356 (0.7); 3.1018 (1.2); 3.0743 (0.7); 2.8503 (7.6); 2.7007 (1.1); 2.6685 (1.2); 2.1972 (0.6); 2.1705 (0.9); 2.1631 (0.9); 2.0947 (0.6); 2.0378 (6.7); 1.8932 (1.0); 1.8650 (16.0); 1.2569 (1.2); 0.0080 (1.2); -

0.0002 (38.5); -0.0084 (1.2) 0.0002 (38.5); -0.0084 (1.2)

1.71-54: 1 H-NMR(400.0 MHz, CDCI3):  1.71-54: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5193 (2.0); 7.5175 (2.1); 7.3645 (0.9); 7.3482 (0.7); 7.3433 (1.1); 7.3273 (0.7); 7.3124 (0.7); 7.3097 (1.0); 7.3058 (1.0); 7.2920 (2.0); 7.2811 (2.4); 7.2716 (0.9); 7.2691 (1.0); 7.2645 (1.1); 7.2589 (17.0); 7.2514 (0.8); 7.0226δ = 7.5193 (2.0); 7.5175 (2.1); 7.3645 (0.9); 7.3482 (0.7); 7.3433 (1.1); 7.3273 (0.7); 7.3124 (0.7); 7.3097 (1.0); 7.3058 (1.0); 7.2920 (2.0); 7.2811 (2.4); 7.2716 (0.9); 7.2691 (1.0); 7.2645 (1.1); 7.2589 (17.0); 7.2514 (0.8); 7.0226

(1.2) ; 7.0032 (1.5); 6.9828 (1.1); 5.2971 (2.2); 3.4794 (2.8); 2.4434 (0.7); 2.0308 (5.2); 2.0291 (5.3); 1.8670 (16.0);(1.2); 7.0032 (1.5); 6.9828 (1.1); 5.2971 (2.2); 3.4794 (2.8); 2.4434 (0.7); 2.0308 (5.2); 2.0291 (5.3); 1.8670 (16.0);

1.5567 (0.9); -0.0002 (8.9) 1.5567 (0.9); -0.0002 (8.9)

1.71-55: 1 H-NMR(400.0 MHz, CDCI3):  1.71-55: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5290 (2.0); 7.5270 (2.0); 7.4149 (0.6); 7.3663 (0.9); 7.3453 (0.6); 7.2603 (24.9); 7.0288 (1.2); 7.0093 (1.4); 7.0082 (1.3); 6.9887 (1.0); 5.2984 (0.7); 4.1176 (0.5); 3.5751 (0.8); 3.5566 (0.5); 3.5466 (0.7); 2.0291 (5.2); 2.0272δ = 7.5290 (2.0); 7.5270 (2.0); 7.4149 (0.6); 7.3663 (0.9); 7.3453 (0.6); 7.2603 (24.9); 7.0288 (1.2); 7.0093 (1.4); 7.0082 (1.3); 6,987 (1.0); 5.2984 (0.7); 4.1176 (0.5); 3.5751 (0.8); 3.5566 (0.5); 3.5466 (0.7); 2.0291 (5.2); 2.0272

(5.2); 1.8790 (16.0); 1.5495 (1.2); -0.0002 (9.4) (5.2); 1.8790 (16.0); 1.5495 (1.2); -0.0002 (9.4)

1.71-56: 1 H-NMR(400.0 MHz, CDCI3):  1.71-56: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5339 (1.9); 7.5319 (1.8); 7.5022 (0.7); 7.3746 (0.8); 7.3535 (0.5); 7.2600 (40.1); 7.0339 (1.1); 7.0142 (1.4); 6.9959 (0.8); 6.9937 (1.0); 3.8659 (0.6); 3.8446 (0.5); 3.8343 (1.0); 3.8242 (0.5); 3.7765 (0.7); 3.7702 (0.8); 3.7518 (0.8); 3.7454 (1.2); 2.3486 (0.6); 2.3149 (0.7); 2.0363 (4.8); 2.0343 (4.7); 1.8790 (16.0); 1.8627 (0.8); 1.8460 (0.6); 1.8360 (0.8); 1.8256 (0.6); 1.5444 (2.4); -0.0002 (14.7); -0.0085 (0.6) 1.71-57: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5339 (1.9); 7.5319 (1.8); 7.5022 (0.7); 7.3746 (0.8); 7.3535 (0.5); 7.2600 (40.1); 7.0339 (1.1); 7.0142 (1.4); 6.9959 (0.8); 6.9937 (1.0); 3.8659 (0.6); 3.8446 (0.5); 3.8343 (1.0); 3.8242 (0.5); 3.7765 (0.7); 3.7702 (0.8); 3.7518 (0.8); 3.7454 (1.2); 2.3486 (0.6); 2.3149 (0.7); 2.0363 (4.8); 2.0343 (4.7); 1.8790 (16.0); 1.8627 (0.8); 1.8460 (0.6); 1.8360 (0.8); 1.8256 (0.6); 1.5444 (2.4); -0.0002 (14.7); -0.0085 (0.6) 1.71-57: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5223 (2.7); 7.5204 (2.8); 7.4462 (1.0); 7.3951 (0.7); 7.3900 (0.6); 7.3790 (0.5); 7.3740 (1.3); 7.3579 (0.6); 7.3529 (0.8); 7.2608 (23.8); 7.0348 (1.7); 7.0150 (2.2); 7.0060 (0.6); 6.9947 (1.6); 5.2983 (3.3); 4.0053 (0.5); 4.0010 (0.6); 3.9935 (0.6); 3.9894 (0.5); 3.8293 (0.5); 3.8245 (0.6); 3.7980 (1.5); 3.7930 (1.2); 3.7872 (0.6); 3.7827 (0.6); 3.7747 (0.6); 3.7703 (0.7); 3.7668 (0.8); 3.7614 (0.7); 2.5036 (0.8); 2.4708 (0.8); 2.4657 (0.5); 2.3551 (0.7); 2.3499 (0.6); 2.3220 (0.7); 2.3167 (0.7); 2.0341 (7.4); 2.0323 (7.3); 1.8959 (1.4); 1.8863 (1.6); 1.8703 (16.0); 1.6428 (0.7); 1.6309 (0.7); 1.3258 (0.9); 1.2978 (0.9); 1.2931 (0.9); 1.2646 (1.1); 1.2278 (6.5); 1.2123 (6.4); 1.1789 (1.0); 1.1630δ = 7.5223 (2.7); 7.5204 (2.8); 7.4462 (1.0); 7.3951 (0.7); 7.3900 (0.6); 7.3790 (0.5); 7.3740 (1.3); 7.3579 (0.6); 7.3529 (0.8); 7.2608 (23.8); 7.0348 (1.7); 7.0150 (2.2); 7.0060 (0.6); 6.9947 (1.6); 5.2983 (3.3); 4.0053 (0.5); 4.0010 (0.6); 3.9935 (0.6); 3.9894 (0.5); 3.8293 (0.5); 3.8245 (0.6); 3.7980 (1.5); 3.7930 (1.2); 3.7872 (0.6); 3.7827 (0.6); 3.7747 (0.6); 3.7703 (0.7); 3.7668 (0.8); 3.7614 (0.7); 2.5036 (0.8); 2.4708 (0.8); 2.4657 (0.5); 2.3551 (0.7); 2.3499 (0.6); 2.3220 (0.7); 2.3167 (0.7); 2.0341 (7.4); 2.0323 (7.3); 1.8959 (1.4); 1.8863 (1.6); 1.8703 (16.0); 1.6428 (0.7); 1.6309 (0.7); 1.3258 (0.9); 1.2978 (0.9); 1.2931 (0.9); 1.2646 (1.1); 1.2278 (6.5); 1.2123 (6.4); 1.1789 (1.0); 1.1630

(0.8); 1.1519 (0.8); 1.1365 (0.8); -0.0002 (11.9) (0.8); 1.1519 (0.8); 1.1365 (0.8); -0.0002 (11.9)

1.71-58: 1 H-NMR(400.0 MHz, CDCI3):  1.71-58: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5785 (0.7); 7.5385 (2.3); 7.5365 (2.3); 7.3868 (0.5); 7.3658 (1.1); 7.3447 (0.7); 7.2606 (19.9); 7.0243 (1.4); 7.0048 (1.7); 6.9844 (1.3); 5.2985 (3.4); 3.3172 (0.8); 3.2833 (0.8); 2.8191 (0.8); 2.7851 (0.7); 2.0508 (0.5); 2.0288δ = 7.5785 (0.7); 7.5385 (2.3); 7.5365 (2.3); 7.3868 (0.5); 7.3658 (1.1); 7.3447 (0.7); 7.2606 (19.9); 7.0243 (1.4); 7.0048 (1.7); 6.9844 (1.3); 5.2985 (3.4); 3.3172 (0.8); 3.2833 (0.8); 2.8191 (0.8); 2.7851 (0.7); 2.0508 (0.5); 2.0288

(6.8); 2.0271 (6.9); 1.9853 (0.6); 1.8898 (16.0); -0.0002 (9.9) (6.8); 2.0271 (6.9); 1.9853 (0.6); 1.8898 (16.0); -0.0002 (9.9)

1.71-59: 1 H-NMR(400.0 MHz, CDCI3):  1.71-59: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7075 (0.8); 7.7024 (1.5); 7.6974 (0.8); 7.5747 (1.8); 7.5728 (1.8); 7.3915 (0.8); 7.3705 (0.5); 7.2956 (0.6); 7.2931 (0.6); 7.2904 (0.6); 7.2879 (0.6); 7.2589 (31.2); 7.2276 (0.9); 7.2076 (1.5); 7.1874 (0.7); 7.0761 (1.1); 7.0663 (0.7); 7.0638 (0.8); 7.0612 (0.8); 7.0585 (1.4); 7.0566 (1.4); 7.0466 (0.7); 7.0439 (0.6); 7.0415 (0.6); 7.0387 (0.9);δ = 7.7075 (0.8); 7.7024 (1.5); 7.6974 (0.8); 7.5747 (1.8); 7.5728 (1.8); 7.3915 (0.8); 7.3705 (0.5); 7.2956 (0.6); 7.2931 (0.6); 7.2904 (0.6); 7.2879 (0.6); 7.2589 (31.2); 7.2276 (0.9); 7.2076 (1.5); 7.1874 (0.7); 7.0761 (1.1); 7.0663 (0.7); 7.0638 (0.8); 7.0612 (0.8); 7.0585 (1.4); 7.0566 (1.4); 7.0466 (0.7); 7.0439 (0.6); 7.0415 (0.6); 7.0387 (0.9);

7.0361 (1.0); 2.0460 (4.6); 2.0440 (4.5); 1.9476 (16.0); 1.5350 (7.1); -0.0002 (11.4) 7.0361 (1.0); 2.0460 (4.6); 2.0440 (4.5); 1.9476 (16.0); 1.5350 (7.1); -0.0002 (11.4)

1.71-63: 1 H-NMR(400.0 MHz, CDCI3):  1.71-63: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9604 (0.7); 7.9562 (1.1); 7.9523 (0.7); 7.7033 (0.6); 7.6883 (0.5); 7.6839 (0.6); 7.6786 (0.5); 7.5829 (1.9); 7.5809 (1.8); 7.4061 (0.9); 7.3953 (1.2); 7.3850 (0.6); 7.3761 (1.0); 7.3750 (1.0); 7.3714 (0.9); 7.3675 (1.6); 7.3638 (0.9); 7.2597 (20.8); 7.0907 (1.1); 7.0709 (1.4); 7.0504 (1.0); 2.0523 (4.6); 2.0504 (4.6); 1.9535 (16.0); 1.5424 (5.5); -δ = 7.9604 (0.7); 7.9562 (1.1); 7.9523 (0.7); 7.7033 (0.6); 7.6883 (0.5); 7.6839 (0.6); 7.6786 (0.5); 7.5829 (1.9); 7.5809 (1.8); 7.4061 (0.9); 7.3953 (1.2); 7.3850 (0.6); 7.3761 (1.0); 7.3750 (1.0); 7.3714 (0.9); 7.3675 (1.6); 7.3638 (0.9); 7.2597 (20.8); 7.0907 (1.1); 7.0709 (1.4); 7.0504 (1.0); 2.0523 (4.6); 2.0504 (4.6); 1.9535 (16.0); 1.5424 (5.5); -

0.0002 (7.5) 0.0002 (7.5)

1.71-64: 1 H-NMR(400.0 MHz, CDCI3):  1.71-64: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6732 (0.7); 8.6681 (0.7); 8.6555 (0.7); 8.6504 (0.7); 7.5837 (1.9); 7.5817 (1.8); 7.3736 (0.9); 7.3621 (0.5); 7.3571 (0.8); 7.3524 (0.6); 7.3506 (0.6); 7.3453 (0.5); 7.3409 (0.6); 7.3359 (0.7); 7.3292 (0.6); 7.3240 (0.5); 7.2599 (10.3); 7.1502 (0.9); 7.1289 (0.8); 7.1250 (1.0); 7.1037 (0.8); 7.0339 (1.1); 7.0150 (1.3); 7.0130 (1.2); 6.9943 (1.0);δ = 8.6732 (0.7); 8.6681 (0.7); 8.6555 (0.7); 8.6504 (0.7); 7.5837 (1.9); 7.5817 (1.8); 7.3736 (0.9); 7.3621 (0.5); 7.3571 (0.8); 7.3524 (0.6); 7.3506 (0.6); 7.3453 (0.5); 7.3409 (0.6); 7.3359 (0.7); 7.3292 (0.6); 7.3240 (0.5); 7.2599 (10.3); 7.1502 (0.9); 7.1289 (0.8); 7.1250 (1.0); 7.1037 (0.8); 7.0339 (1.1); 7.0150 (1.3); 7.0130 (1.2); 6.9943 (1.0);

5.2978 (3.0); 2.0377 (5.1); 2.0360 (5.0); 1.9692 (16.0); -0.0002 (4.4) 5.2978 (3.0); 2.0377 (5.1); 2.0360 (5.0); 1.9692 (16.0); -0.0002 (4.4)

1.71-65: 1 H-NMR(400.0 MHz, CDCI3):  1.71-65: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.2828 (0.5); 8.2803 (0.6); 8.2780 (0.5); 8.2728 (0.5); 8.2706 (0.6); 8.2680 (0.6); 8.2658 (0.5); 8.1517 (0.5); 8.1493 (1.0); 8.1470 (0.5); 8.1307 (0.6); 8.1283 (1.1); 8.1260 (0.6); 7.5681 (1.7); 7.5661 (1.7); 7.3409 (0.8); 7.3199 (0.5); 7.2594 (25.5); 7.0240 (1.0); 7.0167 (0.7); 7.0141 (0.8); 7.0047 (1.5); 7.0021 (1.4); 6.9984 (0.7); 6.9956 (0.8);δ = 8.2828 (0.5); 8.2803 (0.6); 8.2780 (0.5); 8.2728 (0.5); 8.2706 (0.6); 8.2680 (0.6); 8.2658 (0.5); 8.1517 (0.5); 8.1493 (1.0); 8.1470 (0.5); 8.1307 (0.6); 8.1283 (1.1); 8.1260 (0.6); 7.5681 (1.7); 7.5661 (1.7); 7.3409 (0.8); 7.3199 (0.5); 7.2594 (25.5); 7.0240 (1.0); 7.0167 (0.7); 7.0141 (0.8); 7.0047 (1.5); 7.0021 (1.4); 6.9984 (0.7); 6.9956 (0.8);

6.9857 (1.1); 6.9839 (1.2); 2.0382 (4.3); 2.0362 (4.4); 1.9659 (16.0); 1.5542 (1.7); -0.0002 (9.2) 6.9857 (1.1); 6.9839 (1.2); 2.0382 (4.3); 2.0362 (4.4); 1.9659 (16.0); 1.5542 (1.7); -0.0002 (9.2)

1.71-66: 1 H-NMR(400.0 MHz, CDCI3):  1.71-66: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5985 (0.8); 8.5924 (0.8); 8.3337 (0.6); 8.3302 (0.6); 8.3219 (0.6); 8.3183 (0.6); 7.5883 (1.8); 7.5863 (1.8); 7.3930 (0.8); 7.2600 (25.2); 7.2469 (0.6); 7.2380 (0.5); 7.0720 (1.1); 7.0524 (1.3); 7.0319 (0.9); 2.0537 (4.6); 2.0518δ = 8.5985 (0.8); 8,55924 (0.8); 8.3337 (0.6); 8.3302 (0.6); 8.3219 (0.6); 8.3183 (0.6); 7.5883 (1.8); 7.5863 (1.8); 7.3930 (0.8); 7.2600 (25.2); 7.2469 (0.6); 7.2380 (0.5); 7.0720 (1.1); 7.0524 (1.3); 7.0319 (0.9); 2.0537 (4.6); 2.0518

(4.5); 1.9641 (16.0); -0.0002 (8.7) (4.5); 1.9641 (16.0); -0.0002 (8.7)

1.71-67: 1 H-NMR(400.0 MHz, CDCI3):  1.71-67: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.2489 (0.6); 8.2453 (0.6); 8.2419 (0.7); 8.2396 (0.7); 8.1745 (0.5); 7.5859 (1.8); 7.5839 (1.8); 7.3966 (0.8); 7.3756 (0.5); 7.2599 (27.7); 7.0708 (1.1); 7.0511 (1.3); 7.0305 (0.9); 6.9029 (0.6); 6.8946 (0.6); 6.8808 (0.6); 6.8725δ = 8.2489 (0.6); 8.2453 (0.6); 8.2419 (0.7); 8.2396 (0.7); 8.1745 (0.5); 7.5859 (1.8); 7.5839 (1.8); 7.3966 (0.8); 7.3756 (0.5); 7.2599 (27.7); 7.0708 (1.1); 7.0511 (1.3); 7.0305 (0.9); 6.9029 (0.6); 6.8946 (0.6); 6.8808 (0.6); 6.8725

(0.6); 2.0549 (4.4); 2.0528 (4.4); 1.9568 (16.0); 1.5433 (5.3); -0.0002 (9.9) (0.6); 2.0549 (4.4); 2.0528 (4.4); 1.9568 (16.0); 1.5433 (5.3); -0.0002 (9.9)

1.7-167: 1 H-NMR(400.0 MHz, CDCI3):  1.7-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5113 (1.6); 7.5053 (1.6); 7.2597 (56.8); 2.6142 (4.9); 1.8600 (16.0); 1.5460 (2.0); 1.2557 (0.7); 0.0079 (0.6); -δ = 7.5113 (1.6); 7.5053 (1.6); 7.2597 (56.8); 2.6142 (4.9); 1.8600 (16.0); 1.5460 (2.0); 1.2557 (0.7); 0.0079 (0.6); -

0.0002 (20.0); -0.0085 (0.7) 0.0002 (20.0); -0.0085 (0.7)

1.71-68: 1 H-NMR(400.0 MHz, CDCI3):  1.71-68: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.4383 (0.5); 8.4154 (0.6); 8.3187 (0.8); 8.3133 (1.7); 8.3079 (1.1); 8.2889 (0.7); 7.5807 (1.8); 7.5789 (1.9); 7.4001 (0.8); 7.2595 (33.3); 7.0793 (1.1); 7.0595 (1.5); 7.0392 (1.0); 2.0537 (4.8); 2.0521 (4.9); 1.9541 (16.0); 1.5429δ = 9.4383 (0.5); 8.4154 (0.6); 8.3187 (0.8); 8.3133 (1.7); 8.3079 (1.1); 8.2889 (0.7); 7.5807 (1.8); 7,5789 (1.9); 7.4001 (0.8); 7.2595 (33.3); 7.0793 (1.1); 7.0595 (1.5); 7.0392 (1.0); 2.0537 (4.8); 2.0521 (4.9); 1.9541 (16.0); 1.5429

(0.9); -0.0002 (12.3) (0.9); -0.0002 (12.3)

1.71-69: 1 H-NMR(400.0 MHz, CDCI3):  1.71-69: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.4923 (1.3); 8.4885 (0.9); 8.4802 (0.9); 8.4764 (1.3); 7.5785 (1.8); 7.5765 (1.8); 7.4781 (1.8); 7.4741 (1.2); 7.4661 (1.2); 7.4621 (1.8); 7.4094 (0.8); 7.3883 (0.5); 7.2600 (29.6); 7.0914 (1.1); 7.0718 (1.3); 7.0513 (0.9); 2.0492δ = 8.4923 (1.3); 8.4885 (0.9); 8.4802 (0.9); 8.4764 (1.3); 7.5785 (1.8); 7.5765 (1.8); 7.4781 (1.8); 7.4741 (1.2); 7.4661 (1.2); 7.4621 (1.8); 7.4094 (0.8); 7.3883 (0.5); 7.2600 (29.6); 7.0914 (1.1); 7.0718 (1.3); 7.0513 (0.9); 2.0492

(4.5); 2.0472 (4.5); 1.9520 (16.0); -0.0002 (10.7) (4.5); 2.0472 (4.5); 1.9520 (16.0); -0.0002 (10.7)

1.71-70: 1 H-NMR(400.0 MHz, CDCI3):  1.71-70: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.0851 (1.2); 8.0709 (1.3); 7.5767 (1.8); 7.5747 (1.8); 7.4147 (0.8); 7.3936 (0.5); 7.3315 (1.3); 7.3271 (1.4); 7.2597 (34.8); 7.2090 (0.8); 7.1947 (0.7); 7.0962 (1.1); 7.0763 (1.4); 7.0559 (0.9); 2.0509 (4.4); 2.0488 (4.4); 1.9474δ = 8.0851 (1.2); 8.0709 (1.3); 7.5767 (1.8); 7.5747 (1.8); 7.4147 (0.8); 7.3936 (0.5); 7.3315 (1.3); 7.3271 (1.4); 7.2597 (34.8); 7.2090 (0.8); 7.1947 (0.7); 7.0962 (1.1); 7.0763 (1.4); 7.0559 (0.9); 2.0509 (4.4); 2.0488 (4.4); 1.9474

(16.0); 1.5431 (9.0); -0.0002 (12.0) (16.0); 1.5431 (9.0); -0.0002 (12.0)

1.71-71 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-71: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.4948 (1.1); 8.2514 (1.4); 8.2379 (1.7); 7.6955 (2.3); 7.5705 (2.6); 7.4311 (0.6); 7.4149 (1.0); 7.3943 (0.8); 7.3003 (1.2); 7.2863 (1.6); 7.2594 (50.8); 7.2557 (28.5); 7.2523 (25.1); 7.0966 (1.4); 7.0771 (2.4); 7.0576 (1.6);δ = 9.4948 (1.1); 8.2514 (1.4); 8.2379 (1.7); 7.6955 (2.3); 7.5705 (2.6); 7.4311 (0.6); 7.4149 (1.0); 7.3943 (0.8); 7.3003 (1.2); 7.2863 (1.6); 7.2594 (50.8); 7.2557 (28.5); 7.2523 (25.1); 7.0966 (1.4); 7.0771 (2.4); 7.0576 (1.6);

2.0491 (7.0); 1.9416 (16.0); 1.5353 (9.5); 1.5280 (4.8); -0.0002 (17.8); -0.0074 (9.2) 2.0491 (7.0); 1.9416 (16.0); 1.5353 (9.5); 1.5280 (4.8); -0.0002 (17.8); -0.0074 (9.2)

1.71-72: 1 H-NMR(400.0 MHz, CDCI3):  1.71-72: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5405 (1.1); 7.5386 (1.1); 7.3395 (0.5); 7.2594 (80.1); 7.2099 (0.8); 7.2040 (0.8); 7.0263 (0.6); 7.0073 (0.8); 6.9954 (0.5); 6.9866 (0.6); 6.5981 (0.9); 6.5924 (0.9); 3.7817 (5.7); 2.0250 (2.8); 2.0230 (2.8); 1.9401 (9.4); 1.5360δ = 7.5405 (1.1); 7.5386 (1.1); 7.3395 (0.5); 7.2594 (80.1); 7.2099 (0.8); 7.2040 (0.8); 7.0263 (0.6); 7.0073 (0.8); 6.9954 (0.5); 6.9866 (0.6); 6.5981 (0.9); 6.5924 (0.9); 3.7817 (5.7); 2.0250 (2.8); 2.0230 (2.8); 1.9401 (9.4); 1.5360

(16.0); 0.0079 (1.1); -0.0002 (29.5); -0.0085 (1.1) (16.0); 0.0079 (1.1); -0.0002 (29.5); -0.0085 (1.1)

1.71-73: 1 H-NMR(400.0 MHz, CDCI3):  1.71-73: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5596 (1.8); 7.5577 (1.8); 7.4696 (1.9); 7.4607 (2.0); 7.3634 (0.8); 7.3423 (0.5); 7.2675 (34.5); 7.0595 (1.1); 7.0405 (1.3); 7.0389 (1.2); 7.0199 (1.0); 6.9662 (2.1); 6.9573 (2.0); 2.0419 (4.6); 2.0399 (4.6); 1.9789 (16.0); 1.6991 (9.3); -0.0002 (13.0) 1.71-74: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5596 (1.8); 7.5577 (1.8); 7.4696 (1.9); 7.4607 (2.0); 7.3634 (0.8); 7.3423 (0.5); 7.2675 (34.5); 7.0595 (1.1); 7.0405 (1.3); 7.0389 (1.2); 7.0199 (1.0); 6.9662 (2.1); 6.9573 (2.0); 2.0419 (4.6); 2.0399 (4.6); 1.9789 (16.0); 1.6991 (9.3); -0.0002 (13.0) 1.71-74: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5483 (1.8); 7.5464 (1.8); 7.5182 (0.5); 7.3662 (0.8); 7.3452 (0.5); 7.2797 (4.3); 7.2593 (86.3); 7.0595 (1.1); 7.0404 (1.3); 7.0198 (1.0); 2.0408 (4.6); 2.0388 (4.5); 1.9609 (16.0); 1.5378 (4.2); 0.0079 (1.1); -0.0002 (30.6); -δ = 7.5483 (1.8); 7.5464 (1.8); 7.5182 (0.5); 7.3662 (0.8); 7.3452 (0.5); 7.2797 (4.3); 7.2593 (86.3); 7.0595 (1.1); 7.0404 (1.3); 7.0198 (1.0); 2.0408 (4.6); 2.0388 (4.5); 1.9609 (16.0); 1.5378 (4.2); 0.0079 (1.1); -0.0002 (30.6); -

0.0085 (1.1) 0.0085 (1.1)

1.71-75: 1 H-NMR(400.0 MHz, CDCI3):  1.71-75: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9196 (3.0); 7.5530 (1.7); 7.5512 (1.8); 7.3641 (0.8); 7.3431 (0.5); 7.2596 (35.8); 7.0502 (1.1); 7.0312 (1.3);δ = 7.9196 (3.0); 7.5530 (1.7); 7.5512 (1.8); 7.3641 (0.8); 7.3431 (0.5); 7.2596 (35.8); 7.0502 (1.1); 7.0312 (1.3);

7.0105 (1.0); 4.0832 (11.9); 2.0375 (4.5); 2.0356 (4.6); 1.9484 (16.0); 1.5381 (2.2); -0.0002 (12.9) 7.0105 (1.0); 4.0832 (11.9); 2.0375 (4.5); 2.0356 (4.6); 1.9484 (16.0); 1.5381 (2.2); -0.0002 (12.9)

1.71-76: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-76: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8691 (2.6); 7.5975 (1.7); 7.4806 (0.6); 7.4601 (1.0); 7.4399 (0.6); 7.4008 (4.0); 7.1429 (1.5); 7.1226 (2.2); 7.1034 (1.3); 3.3112 (40.4); 2.5050 (52.0); 2.5006 (67.1); 2.4963 (49.2); 1.9429 (16.0); 1.9154 (7.5); -0.0002 (11.7) 1.71-77: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.8691 (2.6); 7.5975 (1.7); 7.4806 (0.6); 7.4601 (1.0); 7.4399 (0.6); 7,4008 (4.0); 7.1429 (1.5); 7.1226 (2.2); 7.1034 (1.3); 3.3112 (40.4); 2.5050 (52.0); 2.5006 (67.1); 2.4963 (49.2); 1.9429 (16.0); 1.9154 (7.5); -0.0002 (11.7) 1.71-77: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5140 (2.8); 7.5121 (2.8); 7.3542 (0.7); 7.3492 (0.6); 7.3332 (1.3); 7.3173 (0.6); 7.3121 (0.8); 7.2602 (49.7); 7.0054 (1.7); 6.9864 (2.0); 6.9846 (1.8); 6.9658 (1.5); 3.7419 (0.6); 3.7386 (0.6); 3.7356 (0.8); 3.7234 (0.6); 3.7206 (0.9); 3.7178 (0.8); 3.7026 (0.7); 3.6556 (0.6); 3.6397 (1.0); 3.6224 (0.7); 3.6187 (0.8); 3.3890 (1.0); 3.3715 (1.0); 3.3551 (1.3); 3.3376 (1.2); 3.1469 (1.4); 3.1343 (1.4); 3.1130 (1.1); 3.1004 (1.0); 2.1696 (2.2); 2.0170 (7.6); 2.0152δ = 7.5140 (2.8); 7.5121 (2.8); 7.3542 (0.7); 7.3492 (0.6); 7.3332 (1.3); 7.3173 (0.6); 7.3121 (0.8); 7.2602 (49.7); 7.0054 (1.7); 6.9864 (2.0); 6.9846 (1.8); 6.9658 (1.5); 3.7419 (0.6); 3.7386 (0.6); 3.7356 (0.8); 3.7234 (0.6); 3.7206 (0.9); 3.7178 (0.8); 3.7026 (0.7); 3.6556 (0.6); 3.6397 (1.0); 3.6224 (0.7); 3.6187 (0.8); 3.3890 (1.0); 3.3715 (1.0); 3.3551 (1.3); 3.3376 (1.2); 3.1469 (1.4); 3.1343 (1.4); 3.1130 (1.1); 3.1004 (1.0); 2.1696 (2.2); 2.0170 (7.6); 2.0152

(7.5) ; 1.8832 (16.0); 1.8496 (0.5); 1.8325 (0.5); 1.8292 (0.6); 1.7668 (0.5); 1.7495 (0.6); 1.7060 (0.7); 1.6756 (0.8); 1.6586 (0.7); 1.6551 (0.6); 1.5703 (0.7); 1.5546 (14.4); 1.5405 (0.5); 1.5353 (0.6); 1.0993 (13.0); 0.0079 (0.6); -(7.5); 1.8832 (16.0); 1.8496 (0.5); 1.8325 (0.5); 1.8292 (0.6); 1.7668 (0.5); 1.7495 (0.6); 1.7060 (0.7); 1.6756 (0.8); 1.6586 (0.7); 1.6551 (0.6); 1.5703 (0.7); 1.5546 (14.4); 1.5405 (0.5); 1.5353 (0.6); 1.0993 (13.0); 0.0079 (0.6); -

0.0002 (17.6) 0.0002 (17.6)

1.71-78: 1 H-NMR(400.0 MHz, CDCI3):  1.71-78: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5182 (1.8); 7.5162 (1.8); 7.3572 (0.8); 7.3361 (0.5); 7.2602 (33.1); 7.0257 (1.0); 7.0063 (1.2); 6.9857 (0.9); 3.8025 (0.6); 3.7886 (0.6); 3.7591 (0.6); 3.7414 (0.7); 3.7373 (0.8); 3.7277 (0.5); 3.7196 (0.8); 3.7088 (0.7); 3.6910 (0.6); 3.3939 (0.7); 3.3793 (0.7); 3.3721 (0.6); 3.3575 (0.6); 3.2233 (0.6); 3.2083 (0.5); 3.2051 (0.5); 3.1902 (0.5); 3.1835 (0.5); 3.1691 (0.5); 3.1651 (0.5); 3.1505 (0.7); 2.1696 (1.1); 2.0269 (4.6); 2.0251 (4.6); 1.8675 (16.0); 1.5533δ = 7.5182 (1.8); 7.5162 (1.8); 7.3572 (0.8); 7.3361 (0.5); 7.2602 (33.1); 7.0257 (1.0); 7.0063 (1.2); 6.9857 (0.9); 3.8025 (0.6); 3,7886 (0.6); 3.7591 (0.6); 3.7414 (0.7); 3.7373 (0.8); 3.7277 (0.5); 3.7196 (0.8); 3.7088 (0.7); 3.6910 (0.6); 3.3939 (0.7); 3.3793 (0.7); 3.3721 (0.6); 3.3575 (0.6); 3.2233 (0.6); 3.2083 (0.5); 3.2051 (0.5); 3.1902 (0.5); 3.1835 (0.5); 3.1691 (0.5); 3.1651 (0.5); 3.1505 (0.7); 2.1696 (1.1); 2.0269 (4.6); 2.0251 (4.6); 1.8675 (16.0); 1.5533

(9.6) ; -0.0002 (11.9) (9.6); -0.0002 (11.9)

1.71-79: 1 H-NMR(400.0 MHz, CDCI3):  1.71-79: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5121 (1.7); 7.5102 (1.7); 7.3447 (0.8); 7.2601 (30.6); 7.0163 (1.0); 6.9961 (1.3); 6.9766 (0.9); 4.9368 (0.8); 4.9285 (1.7); 4.9202 (0.8); 3.8310 (0.7); 3.8262 (0.9); 3.8221 (1.2); 3.8155 (3.0); 3.8062 (3.1); 3.7997 (1.1); 3.7956 (0.8); 3.7899 (0.6); 3.4391 (1.6); 3.4308 (1.6); 3.4246 (1.6); 3.4162 (1.5); 2.1698 (1.0); 2.0199 (4.7); 2.0182 (4.6);δ = 7.5121 (1.7); 7.5102 (1.7); 7.3447 (0.8); 7.2601 (30.6); 7.0163 (1.0); 6.9961 (1.3); 6.9766 (0.9); 4.9368 (0.8); 4.9285 (1.7); 4.9202 (0.8); 3.8310 (0.7); 3.8262 (0.9); 3.8221 (1.2); 3.8155 (3.0); 3.8062 (3.1); 3.7997 (1.1); 3.7956 (0.8); 3.7899 (0.6); 3.4391 (1.6); 3.4308 (1.6); 3.4246 (1.6); 3.4162 (1.5); 2.1698 (1.0); 2.0199 (4.7); 2.0182 (4.6);

1.8770 (16.0); 1.5524 (9.7); -0.0002 (10.6) 1.8770 (16.0); 1.5524 (9.7); -0.0002 (10.6)

1.71-80: 1 H-NMR(400.0 MHz, CDCI3):  1.71-80: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5256 (2.4); 7.5239 (2.6); 7.3886 (0.5); 7.3675 (1.0); 7.3465 (0.6); 7.2607 (34.3); 7.0395 (1.4); 7.0195 (2.0); 6.9995 (1.3); 5.5861 (0.6); 3.7359 (0.6); 3.4220 (0.6); 3.4106 (0.5); 3.4059 (0.6); 3.1176 (0.9); 3.1026 (0.5); 3.0981 (0.5); 3.0831 (0.8); 2.2603 (0.7); 2.2500 (0.8); 2.2420 (0.5); 2.2357 (1.7); 2.2260 (0.8); 2.2173 (1.4); 2.2143 (1.3); 2.2049 (0.6); 2.1746 (0.6); 2.0350 (6.8); 1.8621 (16.0); 1.6945 (0.5); 1.6805 (0.5); 1.5795 (3.4); 1.2585 (0.5); 0.0692δ = 7.5256 (2.4); 7.5239 (2.6); 7.3886 (0.5); 7.3675 (1.0); 7.3465 (0.6); 7.2607 (34.3); 7.0395 (1.4); 7.0195 (2.0); 6.9995 (1.3); 5.5861 (0.6); 3.7359 (0.6); 3.4220 (0.6); 3.4106 (0.5); 3.4059 (0.6); 3.1176 (0.9); 3.1026 (0.5); 3.0981 (0.5); 3.0831 (0.8); 2.2603 (0.7); 2.2500 (0.8); 2.2420 (0.5); 2.2357 (1.7); 2.2260 (0.8); 2.2173 (1.4); 2.2143 (1.3); 2.2049 (0.6); 2.1746 (0.6); 2.0350 (6.8); 1.8621 (16.0); 1.6945 (0.5); 1.6805 (0.5); 1.5795 (3.4); 1.2585 (0.5); 0.0692

(0.9); -0.0002 (13.0); -0.0084 (0.6) (0.9); -0.0002 (13.0); -0.0084 (0.6)

1.71-81 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-81: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5200 (2.1); 7.5180 (2.0); 7.3680 (0.9); 7.3469 (0.5); 7.2610 (30.1); 7.0341 (1.2); 7.0146 (1.4); 6.9967 (0.8); 6.9940 (1.2); 3.3936 (0.5); 3.3916 (0.6); 3.3890 (0.6); 3.3870 (0.6); 3.3693 (0.5); 3.3674 (0.6); 3.3192 (0.6); 3.3005 (0.5); 3.2372 (0.6); 3.0329 (0.5); 3.0186 (0.6); 2.9944 (0.5); 2.3873 (0.8); 2.3652 (0.7); 2.3447 (1.0); 2.3227 (0.8); 2.0305 (4.9); 2.0287 (5.0); 2.0050 (0.9); 1.9878 (0.8); 1.9624 (0.7); 1.9452 (0.7); 1.8638 (16.0); 1.5761 (1.2); -0.0002δ = 7.5200 (2.1); 7.5180 (2.0); 7.3680 (0.9); 7.3469 (0.5); 7.2610 (30.1); 7.0341 (1.2); 7.0146 (1.4); 6.9967 (0.8); 6.9940 (1.2); 3.3936 (0.5); 3.3916 (0.6); 3.3890 (0.6); 3.3870 (0.6); 3.3693 (0.5); 3.3674 (0.6); 3.3192 (0.6); 3.3005 (0.5); 3.2372 (0.6); 3.0329 (0.5); 3.0186 (0.6); 2.9944 (0.5); 2.3873 (0.8); 2.3652 (0.7); 2.3447 (1.0); 2.3227 (0.8); 2.0305 (4.9); 2.0287 (5.0); 2.0050 (0.9); 1.9878 (0.8); 1.9624 (0.7); 1.9452 (0.7); 1.8638 (16.0); 1.5761 (1.2); -0.0002

(11.1) (11.1)

1.71-82: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-82: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 11.4802 (1.8); 7.9210 (1.1); 7.8062 (3.0); 7.8043 (2.8); 7.5287 (0.6); 7.5073 (1.2); 7.4864 (0.7); 7.1983 (1.7); 7.1783 (2.5); 7.1579 (1.4); 4.1911 (3.1); 4.1774 (3.1); 3.3158 (19.0); 2.9469 (14.5); 2.5096 (24.0); 2.5052 (46.5);δ = 11.4802 (1.8); 7.9210 (1.1); 7.8062 (3.0); 7.8043 (2.8); 7.5287 (0.6); 7.5073 (1.2); 7.4864 (0.7); 7.1983 (1.7); 7.1783 (2.5); 7.1579 (1.4); 4.1911 (3.1); 4.1774 (3.1); 3.3158 (19.0); 2.9469 (14.5); 2.5096 (24.0); 2.5052 (46.5);

2.5007 (60.8); 2.4961 (42.5); 2.4916 (20.3); 1.9196 (7.6); 1.7205 (16.0); -0.0002 (16.5); -0.0086 (0.8) 2.5007 (60.8); 2.4961 (42.5); 2.4916 (20.3); 1.9196 (7.6); 1.7205 (16.0); -0.0002 (16.5); -0.0086 (0.8)

1.71-83: 1 H-NMR(400.0 MHz, CDCI3):  1.71-83: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5123 (1.8); 7.5103 (1.8); 7.3472 (0.8); 7.3262 (0.5); 7.2601 (29.0); 7.0159 (1.0); 6.9967 (1.3); 6.9761 (0.9); 3.6787 (0.6); 3.6717 (1.2); 3.6664 (1.2); 3.6612 (0.6); 3.6448 (1.7); 3.6390 (0.8); 3.6325 (0.7); 3.6174 (0.8); 3.5235 (0.5); 3.2634 (0.9); 3.2611 (0.7); 3.2487 (0.6); 3.2462 (0.6); 3.2386 (0.8); 3.2346 (1.1); 3.2164 (0.6); 3.2101 (0.7); 3.2027 (0.6); 3.2004 (0.6); 3.1866 (0.5); 2.0256 (4.7); 2.0237 (4.7); 1.8684 (16.0); 1.5531 (8.6); -0.0002 (10.4) 1.71-84: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5123 (1.8); 7.5103 (1.8); 7.3472 (0.8); 7.3262 (0.5); 7.2601 (29.0); 7.0159 (1.0); 6.9967 (1.3); 6.9761 (0.9); 3.6787 (0.6); 3.6717 (1.2); 3.6664 (1.2); 3.6612 (0.6); 3.6448 (1.7); 3.6390 (0.8); 3.6325 (0.7); 3.6174 (0.8); 3.5235 (0.5); 3.2634 (0.9); 3.2611 (0.7); 3.2487 (0.6); 3.2462 (0.6); 3.2386 (0.8); 3.2346 (1.1); 3.2164 (0.6); 3.2101 (0.7); 3.2027 (0.6); 3.2004 (0.6); 3.1866 (0.5); 2.0256 (4.7); 2.0237 (4.7); 1.8684 (16.0); 1.5531 (8.6); -0.0002 (10.4) 1.71-84: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5087 (1.7); 7.5068 (1.6); 7.3352 (0.8); 7.3142 (0.5); 7.2998 (1.1); 7.2979 (1.3); 7.2953 (1.1); 7.2933 (1.0); 7.2596 (19.7); 6.9966 (1.1); 6.9777 (1.2); 6.9759 (1.1); 6.9570 (0.9); 6.2702 (0.8); 6.2655 (0.8); 6.2621 (0.8); 6.2575 (0.8); 6.1125 (0.9); 6.1107 (0.8); 6.1045 (0.8); 6.1026 (0.7); 5.2976 (9.4); 4.3606 (1.9); 4.3468 (1.8); 2.0141 (4.5);δ = 7.5087 (1.7); 7.5068 (1.6); 7.3352 (0.8); 7.3142 (0.5); 7.2998 (1.1); 7.2979 (1.3); 7.2953 (1.1); 7.2933 (1.0); 7.2596 (19.7); 6.9966 (1.1); 6.9777 (1.2); 6.9759 (1.1); 6.9570 (0.9); 6.2702 (0.8); 6.2655 (0.8); 6.2621 (0.8); 6.2575 (0.8); 6.1125 (0.9); 6.1107 (0.8); 6.1045 (0.8); 6.1026 (0.7); 5.2976 (9.4); 4.3606 (1.9); 4.3468 (1.8); 2.0141 (4.5);

2.0123 (4.4); 1.8778 (16.0); 1.5484 (3.0); -0.0002 (7.1) 2.0123 (4.4); 1.8778 (16.0); 1.5484 (3.0); -0.0002 (7.1)

1.71-85: 1 H-NMR(400.0 MHz, CDCI3):  1.71-85: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5102 (1.7); 7.5084 (1.6); 7.3311 (0.8); 7.2589 (13.9); 7.1656 (1.0); 7.1623 (1.0); 7.1529 (1.2); 7.1497 (1.2); 6.9924 (1.1); 6.9732 (1.2); 6.9716 (1.1); 6.9527 (0.9); 6.9052 (0.7); 6.8965 (1.1); 6.8926 (0.6); 6.8839 (1.1); 6.8686 (0.8); 6.8661 (0.8); 6.8600 (0.5); 4.5295 (1.8); 4.5278 (1.8); 4.5149 (1.8); 4.5132 (1.7); 2.0115 (4.5); 2.0098 (4.4);δ = 7.5102 (1.7); 7.5084 (1.6); 7.3311 (0.8); 7.2589 (13.9); 7.1656 (1.0); 7.1623 (1.0); 7.1529 (1.2); 7.1497 (1.2); 6.9924 (1.1); 6.9732 (1.2); 6.9716 (1.1); 6.9527 (0.9); 6.9052 (0.7); 6.8965 (1.1); 6.8926 (0.6); 6.8839 (1.1); 6.8686 (0.8); 6.8661 (0.8); 6.8600 (0.5); 4.5295 (1.8); 4.5278 (1.8); 4.5149 (1.8); 4.5132 (1.7); 2.0115 (4.5); 2.0098 (4.4);

1.8833 (16.0); 1.5526 (1.0); -0.0002 (5.2) 1.8833 (16.0); 1.5526 (1.0); -0.0002 (5.2)

1.71-86: 1 H-NMR(400.0 MHz, CDCI3):  1.71-86: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5108 (1.6); 7.5090 (1.7); 7.3388 (0.8); 7.3183 (1.0); 7.3149 (1.4); 7.3106 (0.9); 7.2593 (29.2); 7.0004 (1.0); 6.9812 (1.2); 6.9607 (0.9); 6.2542 (1.0); 6.2517 (1.0); 4.2077 (1.7); 4.1937 (1.6); 2.0137 (4.5); 2.0119 (4.6); 1.8759 (16.0); 1.5388 (3.9); -0.0002 (11.0) 1.71-87: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5108 (1.6); 7.5090 (1.7); 7.3388 (0.8); 7.3183 (1.0); 7.3149 (1.4); 7.3106 (0.9); 7.2593 (29.2); 7,0004 (1.0); 6.9812 (1.2); 6.9607 (0.9); 6.2542 (1.0); 6.2517 (1.0); 4.2077 (1.7); 4.1937 (1.6); 2.0137 (4.5); 2.0119 (4.6); 1.8759 (16.0); 1.5388 (3.9); -0.0002 (11.0) 1.71-87: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5180 (2.1); 7.3347 (0.8); 7.3136 (0.5); 7.2590 (35.5); 7.2330 (0.8); 7.2257 (0.9); 7.2206 (0.8); 7.2132 (0.8); 7.0080 (1.2); 7.0036 (1.1); 6.9941 (1.3); 6.9739 (1.4); 6.9542 (1.0); 6.9156 (0.9); 6.9127 (0.9); 6.9032 (0.8); 6.9004 (0.8); 4.3719 (2.0); 4.3578 (1.9); 2.0141 (5.3); 1.8876 (16.0); 1.8248 (0.5); 1.5368 (3.9); 0.0078 (0.6); -0.0002 (13.3);δ = 7.5180 (2.1); 7.3347 (0.8); 7.3136 (0.5); 7.2590 (35.5); 7.2330 (0.8); 7.2257 (0.9); 7.2206 (0.8); 7.2132 (0.8); 7.0080 (1.2); 7.0036 (1.1); 6.9941 (1.3); 6.9739 (1.4); 6.9542 (1.0); 6.9156 (0.9); 6.9127 (0.9); 6.9032 (0.8); 6.9004 (0.8); 4.3719 (2.0); 4.3578 (1.9); 2.0141 (5.3); 1.8876 (16.0); 1.8248 (0.5); 1.5368 (3.9); 0.0078 (0.6); -0.0002 (13.3);

-0.0084 (0.5) -0.0084 (0.5)

1.71-88: 1 H-NMR(400.0 MHz, CDCI3):  1.71-88: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.1711 (1.6); 7.5059 (1.7); 7.5041 (1.7); 7.3491 (0.8); 7.2594 (60.4); 7.0054 (1.1); 6.9952 (0.5); 6.9859 (1.3); 6.9655 (1.0); 4.1809 (1.9); 4.1795 (1.9); 4.1667 (1.9); 4.1653 (1.9); 2.1911 (8.0); 2.0161 (4.6); 2.0144 (4.6); 1.8652δ = 8.1711 (1.6); 7.5059 (1.7); 7.5041 (1.7); 7.3491 (0.8); 7.2594 (60.4); 7.0054 (1.1); 6.9952 (0.5); 6.9859 (1.3); 6.9655 (1.0); 4.1809 (1.9); 4.1795 (1.9); 4.1667 (1.9); 4.1653 (1.9); 2.1911 (8.0); 2.0161 (4.6); 2.0144 (4.6); 1.8652

(16.0); 1.5358 (3.1); 0.0079 (0.7); -0.0002 (22.4); -0.0084 (0.7) (16.0); 1.5358 (3.1); 0.0079 (0.7); -0.0002 (22.4); -0.0084 (0.7)

1.71-89: 1 H-NMR(400.0 MHz, CDCI3):  1.71-89: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5142 (1.8); 7.5125 (1.7); 7.3612 (0.6); 7.3564 (0.6); 7.3452 (0.5); 7.3402 (1.0); 7.3191 (0.5); 7.2597 (26.0); 6.9961 (1.2); 6.9767 (1.4); 6.9564 (0.9); 4.5485 (3.2); 4.5339 (3.1); 2.2873 (11.6); 2.0192 (4.9); 2.0175 (4.6); 1.8809δ = 7.5142 (1.8); 7.5125 (1.7); 7.3612 (0.6); 7.3564 (0.6); 7.3452 (0.5); 7.3402 (1.0); 7.3191 (0.5); 7.2597 (26.0); 6.9961 (1.2); 6.9767 (1.4); 6.9564 (0.9); 4.5485 (3.2); 4.5339 (3.1); 2.2873 (11.6); 2.0192 (4.9); 2.0175 (4.6); 1.8809

(16.0); 1.5390 (2.8); -0.0002 (10.2) (16.0); 1.5390 (2.8); -0.0002 (10.2)

1.71-90: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-90: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 11.3424 (1.8); 7.7600 (2.9); 7.7580 (2.7); 7.5264 (0.7); 7.5222 (0.8); 7.5053 (1.7); 7.4845 (1.1); 7.2065 (1.6); 7.1862 (2.4); 7.1661 (1.4); 5.7533 (1.4); 3.5161 (2.2); 3.3499 (0.6); 3.3318 (1.5); 3.3171 (1.6); 3.3003 (0.7); 3.0638 (16.0); 2.6119 (1.4); 2.5944 (2.7); 2.5764 (1.5); 2.5231 (1.4); 2.5098 (26.0); 2.5053 (54.0); 2.5007 (74.5); 2.4961δ = 11.3424 (1.8); 7.7600 (2.9); 7.7580 (2.7); 7.5264 (0.7); 7.5222 (0.8); 7.5053 (1.7); 7.4845 (1.1); 7.2065 (1.6); 7.1862 (2.4); 7.1661 (1.4); 5.7533 (1.4); 3.5161 (2.2); 3.3499 (0.6); 3.3318 (1.5); 3.3171 (1.6); 3.3003 (0.7); 3.0638 (16.0); 2.6119 (1.4); 2.5944 (2.7); 2.5764 (1.5); 2.5231 (1.4); 2.5098 (26.0); 2.5053 (54.0); 2,5007 (74.5); 2.4961

(52.4) ; 2.4916 (25.6); 1.9879 (2.2); 1.9261 (7.0); 1.9081 (0.8); 1.6795 (15.6); 1.1924 (0.6); 1.1746 (1.2); 1.1569 (0.6);(52.4); 2.4916 (25.6); 1.9879 (2.2); 1.9261 (7.0); 1.9081 (0.8); 1.6795 (15.6); 1.1924 (0.6); 1.1746 (1.2); 1.1569 (0.6);

0.0079 (0.7); -0.0002 (22.7); -0.0085 (0.9) 0.0079 (0.7); -0.0002 (22.7); -0.0085 (0.9)

1.71-91 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-91: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4939 (1.7); 7.4919 (1.7); 7.3429 (0.8); 7.3219 (0.5); 7.2603 (32.2); 7.0059 (1.0); 6.9866 (1.2); 6.9851 (1.2); 6.9660 (0.9); 3.5898 (0.6); 3.5730 (1.6); 3.5579 (1.6); 3.5412 (0.7); 2.8634 (1.3); 2.8466 (2.7); 2.8298 (1.2); 2.4722δ = 7.4939 (1.7); 7.4919 (1.7); 7.3429 (0.8); 7.3219 (0.5); 7.2603 (32.2); 7.0059 (1.0); 6.9866 (1.2); 6.9851 (1.2); 6.9660 (0.9); 3.5898 (0.6); 3.5730 (1.6); 3.5579 (1.6); 3.5412 (0.7); 2.8634 (1.3); 2.8466 (2.7); 2.8298 (1.2); 2.4722

(11.3); 2.0207 (4.5); 2.0187 (4.6); 1.8513 (16.0); 1.5579 (8.3); -0.0002 (11.6) (11.3); 2.0207 (4.5); 2.0187 (4.6); 1.8513 (16.0); 1.5579 (8.3); -0.0002 (11.6)

1.71-92: 1 H-NMR(400.0 MHz, CDCI3):  1.71-92: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4550 (1.9); 7.4532 (1.9); 7.4161 (1.2); 7.4122 (1.2); 7.3461 (0.8); 7.2599 (28.3); 7.2331 (1.3); 7.2280 (1.3); 7.0083 (1.1); 6.9891 (1.4); 6.9686 (1.0); 6.0975 (1.0); 6.0922 (1.6); 6.0872 (0.9); 4.2021 (1.3); 4.1876 (1.9); 4.1723 (1.4); 3.6239 (0.7); 3.6089 (1.6); 3.5940 (1.6); 3.5793 (0.6); 2.0184 (4.9); 2.0167 (5.0); 1.8314 (16.0); 1.5615 (5.8); -δ = 7.4550 (1.9); 7.4532 (1.9); 7.4161 (1.2); 7.4122 (1.2); 7.3461 (0.8); 7.2599 (28.3); 7.2331 (1.3); 7.2280 (1.3); 7.0083 (1.1); 6.9891 (1.4); 6.9686 (1.0); 6.0975 (1.0); 6.0922 (1.6); 6.0872 (0.9); 4.2021 (1.3); 4.1876 (1.9); 4.1723 (1.4); 3.6239 (0.7); 3.6089 (1.6); 3.5940 (1.6); 3.5793 (0.6); 2.0184 (4.9); 2.0167 (5.0); 1.8314 (16.0); 1.5615 (5.8); -

0.0002 (10.3) 0.0002 (10.3)

1.71-93: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-93: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8357 (2.1); 7.8338 (2.1); 7.5284 (0.8); 7.5073 (0.5); 7.2294 (1.2); 7.2094 (1.7); 7.1891 (1.0); 3.8506 (0.7); 3.8318 (1.0); 3.8130 (0.8); 3.7396 (0.6); 3.2692 (0.8); 3.2500 (0.5); 2.6696 (0.5); 2.5228 (2.4); 2.5182 (3.4); 2.5095δ = 7.8357 (2.1); 7.8338 (2.1); 7.5284 (0.8); 7.5073 (0.5); 7.2294 (1.2); 7.2094 (1.7); 7.1891 (1.0); 3.8506 (0.7); 3.8318 (1.0); 3.8130 (0.8); 3.7396 (0.6); 3.2692 (0.8); 3.2500 (0.5); 2.6696 (0.5); 2.5228 (2.4); 2.5182 (3.4); 2.5095

(31.5) ; 2.5050 (64.0); 2.5004 (86.8); 2.4959 (60.1); 2.4914 (27.2); 2.0126 (0.8); 1.9935 (1.2); 1.9744 (0.7); 1.9225(31.5); 2.5050 (64.0); 2,5004 (86.8); 2.4959 (60.1); 2.4914 (27.2); 2.0126 (0.8); 1.9935 (1.2); 1.9744 (0.7); 1.9225

(5.8); 1.7339 (0.8); 1.6477 (16.0); 1.2358 (1.0); -0.0002 (6.4) (5.8); 1.7339 (0.8); 1.6477 (16.0); 1.2358 (1.0); -0.0002 (6.4)

1.71-94: 1 H-NMR(400.0 MHz, CDCI3):  1.71-94: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4493 (5.4); 7.4475 (5.2); 7.3747 (0.6); 7.3587 (1.3); 7.3537 (1.1); 7.3427 (0.7); 7.3377 (2.5); 7.3326 (0.8); 7.3218 (1.2); 7.3167 (1.5); 7.3007 (0.7); 7.2602 (44.7); 6.9972 (3.4); 6.9912 (0.6); 6.9872 (0.6); 6.9784 (3.7); 6.9765 (3.4); 6.9682 (0.6); 6.9578 (2.8); 5.2983 (0.6); 4.1785 (0.5); 4.1530 (1.1); 4.1296 (0.9); 4.0672 (0.9); 4.0533 (0.9); 4.0417 (0.6); 4.0267 (0.6); 3.5393 (0.6); 3.5248 (0.7); 3.5140 (0.9); 3.5003 (0.9); 3.4376 (0.8); 3.4146 (1.2); 3.3905 (0.6); 3.0795 (0.6); 3.0719 (0.6); 3.0579 (1.1); 3.0504 (0.6); 3.0441 (0.6); 3.0364 (1.0); 3.0224 (0.5); 3.0148 (0.5);δ = 7.4493 (5.4); 7.4475 (5.2); 7.3747 (0.6); 7.3587 (1.3); 7.3537 (1.1); 7.3427 (0.7); 7.3377 (2.5); 7.3326 (0.8); 7.3218 (1.2); 7.3167 (1.5); 7.3007 (0.7); 7.2602 (44.7); 6.9972 (3.4); 6.9912 (0.6); 6.9872 (0.6); 6.9784 (3.7); 6.9765 (3.4); 6.9682 (0.6); 6.9578 (2.8); 5.2983 (0.6); 4.1785 (0.5); 4.1530 (1.1); 4.1296 (0.9); 4.0672 (0.9); 4.0533 (0.9); 4.0417 (0.6); 4.0267 (0.6); 3.5393 (0.6); 3.5248 (0.7); 3.5140 (0.9); 3.5003 (0.9); 3.4376 (0.8); 3.4146 (1.2); 3.3905 (0.6); 3.0795 (0.6); 3.0719 (0.6); 3.0579 (1.1); 3.0504 (0.6); 3.0441 (0.6); 3.0364 (1.0); 3.0224 (0.5); 3.0148 (0.5);

2.0135 (16.0); 1.8185 (8.6); 1.7937 (8.6); 1.5538 (6.0); 0.0079 (0.8); -0.0002 (24.1); -0.0085 (0.8) 2.0135 (16.0); 1.8185 (8.6); 1.7937 (8.6); 1.5538 (6.0); 0.0079 (0.8); -0.0002 (24.1); -0.0085 (0.8)

1.71-95: 1 H-NMR(400.0 MHz, CDCI3):  1.71-95: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4346 (5.8); 7.4326 (5.7); 7.3713 (0.7); 7.3554 (1.4); 7.3502 (1.1); 7.3394 (0.8); 7.3343 (2.6); 7.3292 (0.9); 7.3181 (1.1); 7.3133 (1.6); 7.2973 (0.8); 7.2604 (61.1); 6.9964 (3.7); 6.9863 (0.6); 6.9774 (3.9); 6.9755 (3.5); 6.9670 (0.6); 6.9567 (2.9); 4.2075 (0.7); 4.1844 (1.1); 4.1606 (0.7); 3.7807 (0.7); 3.7663 (0.8); 3.7558 (0.7); 3.7403 (0.6); 3.6066 (0.6); 3.5829 (1.2); 3.5609 (0.8); 3.1080 (0.7); 3.0928 (0.8); 3.0705 (0.6); 2.7682 (0.7); 2.7634 (0.6); 2.7483 (1.0); 2.7287 (0.7); 2.3185 (0.9); 2.3002 (1.0); 2.2942 (1.3); 2.2748 (1.3); 2.2691 (1.1); 2.2493 (0.9); 2.0063 (16.0);δ = 7.4346 (5.8); 7.4326 (5.7); 7.3713 (0.7); 7.3554 (1.4); 7.3502 (1.1); 7.3394 (0.8); 7.3343 (2.6); 7.3292 (0.9); 7.3181 (1.1); 7.3133 (1.6); 7.2973 (0.8); 7.2604 (61.1); 6.9964 (3.7); 6.9863 (0.6); 6.9774 (3.9); 6.9755 (3.5); 6.9670 (0.6); 6.9567 (2.9); 4.2075 (0.7); 4.1844 (1.1); 4.1606 (0.7); 3.7807 (0.7); 3,7663 (0.8); 3.7558 (0.7); 3.7403 (0.6); 3.6066 (0.6); 3.5829 (1.2); 3.5609 (0.8); 3.1080 (0.7); 3.0928 (0.8); 3.0705 (0.6); 2.7682 (0.7); 2.7634 (0.6); 2.7483 (1.0); 2.7287 (0.7); 2.3185 (0.9); 2.3002 (1.0); 2.2942 (1.3); 2.2748 (1.3); 2.2691 (1.1); 2.2493 (0.9); 2.0063 (16.0);

2.0048 (15.8); 1.8012 (10.0); 1.7893 (10.2); 1.5598 (6.1); 0.0080 (0.9); -0.0002 (33.6); -0.0085 (1.1) 2.0048 (15.8); 1.8012 (10.0); 1.7893 (10.2); 1.5598 (6.1); 0.0080 (0.9); -0.0002 (33.6); -0.0085 (1.1)

1.71-96: 1 H-NMR(400.0 MHz, CDCI3):  1.71-96: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4269 (2.3); 7.4249 (2.2); 7.3429 (0.6); 7.3219 (1.0); 7.3009 (0.6); 7.2606 (25.7); 6.9858 (1.4); 6.9670 (1.5); 6.9650 (1.4); 6.9463 (1.2); 4.0592 (0.6); 3.4226 (0.7); 3.3960 (1.5); 3.3893 (1.4); 3.3793 (1.4); 3.3723 (1.4); 3.3027δ = 7.4269 (2.3); 7.4249 (2.2); 7.3429 (0.6); 7.3219 (1.0); 7.3009 (0.6); 7.2606 (25.7); 6.9858 (1.4); 6.9670 (1.5); 6.9650 (1.4); 6.9463 (1.2); 4.0592 (0.6); 3.4226 (0.7); 3.3960 (1.5); 3.3893 (1.4); 3.3793 (1.4); 3.3723 (1.4); 3.3027

(16.0); 2.0021 (6.4); 2.0006 (6.3); 1.7942 (7.4); 1.7901 (7.4); 1.5675 (3.1); -0.0002 (13.2) (16.0); 2.0021 (6.4); 2,0006 (6.3); 1.7942 (7.4); 1.7901 (7.4); 1.5675 (3.1); -0.0002 (13.2)

1.71-97: 1 H-NMR(400.0 MHz, CDCI3):  1.71-97: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4347 (1.2); 7.4303 (1.3); 7.3309 (0.9); 7.3099 (0.5); 7.2612 (25.6); 6.9904 (1.3); 6.9715 (1.5); 6.9515 (1.1); 5.2985 (0.6); 3.7943 (0.7); 3.7806 (0.6); 3.7220 (0.9); 3.7046 (0.8); 2.3863 (0.6); 2.3688 (0.6); 2.0039 (4.0); 1.8023δ = 7.4347 (1.2); 7.4303 (1.3); 7.3309 (0.9); 7.3099 (0.5); 7.2612 (25.6); 6.9904 (1.3); 6.9715 (1.5); 6.9515 (1.1); 5.2985 (0.6); 3.7943 (0.7); 3.7806 (0.6); 3.7220 (0.9); 3.7046 (0.8); 2.3863 (0.6); 2.3688 (0.6); 2.0039 (4.0); 1.8023

(16.0); 1.5748 (3.0); -0.0002 (13.6) (16.0); 1.5748 (3.0); -0.0002 (13.6)

1.71-98: 1 H-NMR(400.0 MHz, CDCI3):  1.71-98: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4602 (1.6); 7.4582 (1.5); 7.3418 (0.7); 7.2602 (15.0); 7.0031 (0.9); 6.9842 (1.0); 6.9822 (0.9); 6.9635 (0.8);δ = 7.4602 (1.6); 7.4582 (1.5); 7.3418 (0.7); 7.2602 (15.0); 7.0031 (0.9); 6.9842 (1.0); 6.9822 (0.9); 6.9635 (0.8);

2.0184 (4.5); 2.0167 (4.2); 1.8331 (16.0); 1.5479 (1.3); -0.0002 (8.8) 2.0184 (4.5); 2.0167 (4.2); 1.8331 (16.0); 1.5479 (1.3); -0.0002 (8.8)

1.71-99: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-99: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8569 (2.6); 7.8550 (2.6); 7.5575 (0.6); 7.5364 (1.0); 7.5153 (0.6); 7.2401 (1.5); 7.2201 (2.0); 7.1999 (1.2); 4.4284 (0.7); 4.3943 (1.0); 4.1785 (1.0); 4.1432 (0.7); 4.0835 (1.8); 3.4893 (1.7); 3.3627 (0.7); 3.3130 (93.3); 3.1754 (0.8); 3.1622 (0.7); 2.5233 (1.6); 2.5186 (2.1); 2.5099 (21.9); 2.5054 (45.3); 2.5008 (62.1); 2.4962 (42.4); 2.4916 (19.0); 1.9346 (7.0); 1.6518 (16.0); -0.0002 (15.6) 1.71-100: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 7.8569 (2.6); 7.8550 (2.6); 7.5575 (0.6); 7.5364 (1.0); 7.5153 (0.6); 7.2401 (1.5); 7.2201 (2.0); 7.1999 (1.2); 4.4284 (0.7); 4.3943 (1.0); 4.1785 (1.0); 4.1432 (0.7); 4.0835 (1.8); 3.4893 (1.7); 3.3627 (0.7); 3.3130 (93.3); 3.1754 (0.8); 3.1622 (0.7); 2.5233 (1.6); 2.5186 (2.1); 2.5099 (21.9); 2.5054 (45.3); 2.5008 (62.1); 2.4962 (42.4); 2.4916 (19.0); 1.9346 (7.0); 1.6518 (16.0); -0.0002 (15.6) 1.71-100: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.1548 (3.6); 7.8502 (5.9); 7.8483 (6.0); 7.5665 (0.6); 7.5500 (1.2); 7.5452 (1.0); 7.5334 (0.8); 7.5289 (2.3); 7.5244 (0.9); 7.5123 (1.0); 7.5078 (1.5); 7.4913 (0.6); 7.2329 (3.3); 7.2228 (0.6); 7.2129 (4.5); 7.1928 (2.9); 3.8960 (4.3); 3.5527 (1.1); 3.5294 (1.2); 3.0512 (1.2); 3.0275 (1.1); 2.6742 (0.6); 2.6696 (0.9); 2.6650 (0.6); 2.5510 (0.5); 2.5230 (2.8); 2.5184 (4.1); 2.5096 (56.1); 2.5051 (119.2); 2.5005 (165.8); 2.4959 (115.3); 2.4914 (53.4); 2.4605 (1.0); 2.4565 (1.0); 2.4516 (0.8); 2.3319 (0.8); 2.3273 (1.1); 2.3227 (0.8); 2.1432 (1.0); 2.1156 (2.5); 2.1087 (2.5); 2.0845 (2.5); 2.0697 (1.2); 2.0115 (0.7); 1.9794 (0.8); 1.9620 (0.5); 1.9272 (16.0); 1.9080 (0.8); 1.6936 (6.7); 1.6403 (6.9);δ = 8.1548 (3.6); 7.8502 (5.9); 7.8483 (6.0); 7.5665 (0.6); 7.5500 (1.2); 7.5452 (1.0); 7.5334 (0.8); 7.5289 (2.3); 7.5244 (0.9); 7.5123 (1.0); 7.5078 (1.5); 7.4913 (0.6); 7.2329 (3.3); 7.2228 (0.6); 7.2129 (4.5); 7.1928 (2.9); 3.8960 (4.3); 3.5527 (1.1); 3.5294 (1.2); 3.0512 (1.2); 3.0275 (1.1); 2.6742 (0.6); 2.6696 (0.9); 2.6650 (0.6); 2.5510 (0.5); 2.5230 (2.8); 2.5184 (4.1); 2.5096 (56.1); 2.5051 (119.2); 2,5005 (165.8); 2.4959 (115.3); 2.4914 (53.4); 2.4605 (1.0); 2.4565 (1.0); 2.4516 (0.8); 2.3319 (0.8); 2.3273 (1.1); 2.3227 (0.8); 2.1432 (1.0); 2.1156 (2.5); 2.1087 (2.5); 2.0845 (2.5); 2.0697 (1.2); 2.0115 (0.7); 1.9794 (0.8); 1.9620 (0.5); 1.9272 (16.0); 1.9080 (0.8); 1.6936 (6.7); 1.6403 (6.9);

1.2359 (1.0); 0.8735 (0.7); 0.0080 (3.2); -0.0002 (107.2); -0.0085 (3.4) 1.2359 (1.0); 0.8735 (0.7); 0.0080 (3.2); -0.0002 (107.2); -0.0085 (3.4)

1.71-102: 1 H-NMR(400.0 MHz, CDCI3):  1.71-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3683 (3.8); 7.3666 (3.7); 7.3288 (1.0); 7.3239 (0.9); 7.3130 (0.6); 7.3078 (2.0); 7.3027 (0.7); 7.2921 (0.9); 7.2868 (1.2); 7.2708 (1.0); 7.2603 (84.7); 6.9733 (2.5); 6.9545 (2.8); 6.9525 (2.6); 6.9338 (2.1); 4.2865 (0.5); 4.2778 (0.6); 4.2699 (0.7); 4.2617 (0.5); 2.6465 (1.9); 2.6284 (3.1); 2.6142 (1.2); 2.6114 (1.2); 2.1697 (11.4); 1.9958 (12.5); 1.9943 (12.2); 1.8789 (0.6); 1.8608 (0.9); 1.8491 (0.7); 1.8422 (0.8); 1.8306 (1.4); 1.8136 (14.9); 1.8047 (14.1); 1.7780 (0.7); 1.6518 (0.8); 1.6387 (0.8); 1.6226 (0.7); 1.5563 (16.0); 1.4435 (0.6); 1.4307 (0.7); 1.4212 (0.7); 1.4171δ = 7.3683 (3.8); 7.3666 (3.7); 7.3288 (1.0); 7.3239 (0.9); 7.3130 (0.6); 7.3078 (2.0); 7.3027 (0.7); 7.2921 (0.9); 7.2868 (1.2); 7.2708 (1.0); 7.2603 (84.7); 6.9733 (2.5); 6.9545 (2.8); 6.9525 (2.6); 6.9338 (2.1); 4.2865 (0.5); 4.2778 (0.6); 4.2699 (0.7); 4.2617 (0.5); 2.6465 (1.9); 2.6284 (3.1); 2.6142 (1.2); 2.6114 (1.2); 2.1697 (11.4); 1.9958 (12.5); 1.9943 (12.2); 1.8789 (0.6); 1.8608 (0.9); 1.8491 (0.7); 1.8422 (0.8); 1.8306 (1.4); 1.8136 (14.9); 1.8047 (14.1); 1.7780 (0.7); 1.6518 (0.8); 1.6387 (0.8); 1.6226 (0.7); 1.5563 (16.0); 1.4435 (0.6); 1.4307 (0.7); 1.4212 (0.7); 1.4171

(0.5); 1.4080 (0.6); 1.2089 (8.9); 1.1931 (8.8); 0.0079 (1.0); -0.0002 (32.1); -0.0085 (1.0) (0.5); 1.4080 (0.6); 1.2089 (8.9); 1.1931 (8.8); 0.0079 (1.0); -0.0002 (32.1); -0.0085 (1.0)

1.71-103: 1 H-NMR(400.0 MHz, CDCI3):  1.71-103: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3910 (3.2); 7.3895 (3.2); 7.3563 (0.6); 7.3404 (1.2); 7.3351 (0.9); 7.3245 (0.8); 7.3193 (2.2); 7.3142 (0.8); 7.3029 (1.0); 7.2983 (1.4); 7.2824 (0.7); 7.2603 (40.0); 6.9773 (2.8); 6.9711 (0.5); 6.9672 (0.5); 6.9584 (3.2); 6.9563 (2.9); 6.9479 (0.6); 6.9376 (2.4); 5.2980 (11.8); 2.7609 (1.0); 2.0006 (13.1); 1.9988 (13.1); 1.9793 (1.0); 1.9672 (1.0); 1.9504 (2.3); 1.9349 (1.5); 1.9139 (1.0); 1.9012 (0.8); 1.8815 (0.6); 1.8610 (16.0); 1.8222 (9.4); 1.7730 (0.7); 1.7558δ = 7.3910 (3.2); 7.3895 (3.2); 7.3563 (0.6); 7.3404 (1.2); 7.3351 (0.9); 7.3245 (0.8); 7.3193 (2.2); 7.3142 (0.8); 7.3029 (1.0); 7.2983 (1.4); 7.2824 (0.7); 7.2603 (40.0); 6.9773 (2.8); 6.9711 (0.5); 6.9672 (0.5); 6.9584 (3.2); 6.9563 (2.9); 6.9479 (0.6); 6.9376 (2.4); 5.2980 (11.8); 2.7609 (1.0); 2,0006 (13.1); 1.9988 (13.1); 1.9793 (1.0); 1.9672 (1.0); 1.9504 (2.3); 1.9349 (1.5); 1.9139 (1.0); 1.9012 (0.8); 1.8815 (0.6); 1.8610 (16.0); 1.8222 (9.4); 1.7730 (0.7); 1.7558

(0.8); 0.0080 (0.5); -0.0002 (16.3); -0.0085 (0.6) (0.8); 0.0080 (0.5); -0.0002 (16.3); -0.0085 (0.6)

1.71-104: 1 H-NMR(400.0 MHz, CDCI3):  1.71-104: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5301 (0.5); 7.5190 (0.9); 7.4215 (3.2); 7.3633 (0.6); 7.3472 (1.3); 7.3424 (1.3); 7.3264 (2.4); 7.3100 (1.4); 7.3055 (1.4); 7.2894 (0.7); 7.2601 (142.7); 6.9959 (1.3); 6.9909 (0.7); 6.9800 (3.9); 6.9611 (4.9); 6.9407 (3.4); 5.2985 (3.5); 4.7921 (1.2); 4.7798 (1.3); 2.9565 (1.0); 2.4616 (0.9); 2.4387 (0.9); 2.1604 (1.0); 2.1531 (1.2); 2.1455 (1.2); 2.1253 (0.7); 2.0750 (0.6); 2.0434 (2.1); 2.0291 (3.3); 2.0037 (16.0); 1.9795 (0.9); 1.9063 (1.2); 1.8901 (3.7); 1.8745δ = 7.5301 (0.5); 7.5190 (0.9); 7.4215 (3.2); 7.3633 (0.6); 7.3472 (1.3); 7.3424 (1.3); 7.3264 (2.4); 7.3100 (1.4); 7.3055 (1.4); 7.2894 (0.7); 7.2601 (142.7); 6.9959 (1.3); 6.9909 (0.7); 6,900 (3.9); 6.9611 (4.9); 6.9407 (3.4); 5.2985 (3.5); 4.7921 (1.2); 4.7798 (1.3); 2.9565 (1.0); 2.4616 (0.9); 2.4387 (0.9); 2.1604 (1.0); 2.1531 (1.2); 2.1455 (1.2); 2.1253 (0.7); 2.0750 (0.6); 2.0434 (2.1); 2.0291 (3.3); 2.0037 (16.0); 1.9795 (0.9); 1.9063 (1.2); 1.8901 (3.7); 1.8745

(13.1); 1.8191 (10.1); 1.5468 (20.5); 1.2563 (0.9); 0.0080 (1.5); -0.0002 (52.6); -0.0085 (1.6) (13.1); 1.8191 (10.1); 1.5468 (20.5); 1.2563 (0.9); 0.0080 (1.5); -0.0002 (52.6); -0.0085 (1.6)

1.71-105: 1 H-NMR(400.0 MHz, CDCI3):  1.71-105: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3602 (2.6); 7.3585 (2.6); 7.3394 (0.7); 7.3343 (0.6); 7.3184 (1.3); 7.3025 (0.6); 7.2974 (0.8); 7.2597 (55.4); 6.9815 (1.8); 6.9625 (2.0); 6.9607 (1.9); 6.9419 (1.5); 5.2984 (16.0); 1.9960 (8.0); 1.9946 (8.0); 1.8514 (8.1); 1.8113δ = 7.3602 (2.6); 7.3585 (2.6); 7.3394 (0.7); 7.3343 (0.6); 7.3184 (1.3); 7.3025 (0.6); 7.2974 (0.8); 7.2597 (55.4); 6.9815 (1.8); 6.9625 (2.0); 6.9607 (1.9); 6.9419 (1.5); 5.2984 (16.0); 1.9960 (8.0); 1.9946 (8.0); 1.8514 (8.1); 1.8113

(5.0) ; 1.6973 (0.5); 1.5462 (1.5); 0.0080 (0.6); -0.0002 (21.7); -0.0085 (0.7) (5.0); 1.6973 (0.5); 1.5462 (1.5); 0.0080 (0.6); -0.0002 (21.7); -0.0085 (0.7)

1.71-106: 1 H-NMR(400.0 MHz, CDCI3):  1.71-106: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5187 (0.5); 7.4677 (2.3); 7.4658 (2.2); 7.3365 (0.6); 7.3155 (1.1); 7.3100 (0.6); 7.2998 (0.6); 7.2945 (0.8); 7.2785 (0.6); 7.2598 (89.9); 6.9958 (0.6); 6.9792 (1.4); 6.9605 (1.6); 6.9585 (1.4); 6.9398 (1.1); 4.5616 (0.7); 4.5504 (0.6); 4.5398 (0.7); 4.5292 (0.6); 3.7444 (14.2); 2.6408 (0.7); 2.6142 (0.5); 2.0069 (6.5); 2.0055 (6.4); 1.8463 (8.7); 1.8329 (1.2); 1.8172 (8.8); 1.8043 (0.7); 1.7899 (0.5); 1.5401 (16.0); 0.0080 (1.3); -0.0002 (34.6); -0.0085 (1.2) 1.71-107: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5187 (0.5); 7.4677 (2.3); 7.4658 (2.2); 7.3365 (0.6); 7.3155 (1.1); 7,331 (0.6); 7.2998 (0.6); 7.2945 (0.8); 7.2785 (0.6); 7.2598 (89.9); 6.9958 (0.6); 6.9792 (1.4); 6.9605 (1.6); 6.9585 (1.4); 6.9398 (1.1); 4.5616 (0.7); 4.5504 (0.6); 4.5398 (0.7); 4.5292 (0.6); 3.7444 (14.2); 2.6408 (0.7); 2.6142 (0.5); 2.0069 (6.5); 2.0055 (6.4); 1.8463 (8.7); 1.8329 (1.2); 1.8172 (8.8); 1.8043 (0.7); 1.7899 (0.5); 1.5401 (16.0); 0.0080 (1.3); -0.0002 (34.6); -0.0085 (1.2) 1.71-107: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3652 (1.6); 7.3632 (1.6); 7.3131 (0.8); 7.2600 (21.4); 6.9799 (1.0); 6.9612 (1.0); 6.9590 (1.0); 6.9404 (0.8); 2.8004 (0.6); 2.7835 (1.7); 2.7668 (0.6); 2.0466 (1.7); 2.0415 (1.7); 2.0026 (4.4); 2.0011 (4.4); 1.7714 (16.0); 1.7234δ = 7.3652 (1.6); 7.3632 (1.6); 7.3131 (0.8); 7.2600 (21.4); 6.9799 (1.0); 6.9612 (1.0); 6.9590 (1.0); 6.9404 (0.8); 2.8004 (0.6); 2.7835 (1.7); 2.7668 (0.6); 2.0466 (1.7); 2.0415 (1.7); 2.0026 (4.4); 2.0011 (4.4); 1.7714 (16.0); 1.7234

(3.1) ; 1.7144 (2.1); 1.7076 (0.9); 1.5496 (2.2); 0.4146 (1.8); 0.4095 (1.9); -0.0002 (7.7) (3.1); 1.7144 (2.1); 1.7076 (0.9); 1.5496 (2.2); 0.4146 (1.8); 0.4095 (1.9); -0.0002 (7.7)

1.71-108: 1 H-NMR(400.0 MHz, CDCI3):  1.71-108: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4171 (3.6); 7.3612 (5.3); 7.3314 (1.6); 7.3113 (2.5); 7.2938 (2.0); 7.2603 (80.8); 7.2195 (0.6); 7.2091 (0.6); 6.9945 (0.9); 6.9787 (3.4); 6.9604 (5.4); 6.9397 (3.0); 4.2811 (0.6); 4.1488 (0.7); 3.6257 (0.8); 2.9853 (0.6); 2.0420 (1.1); 1.9983 (11.0); 1.9853 (16.0); 1.9002 (11.7); 1.8483 (15.8); 1.8238 (6.4); 1.5541 (23.7); 1.4320 (1.0); 1.3885 (1.1); 1.3405 (3.1); 1.3279 (3.1); 1.2569 (0.6); 1.1931 (2.8); 1.1785 (2.7); 0.8099 (2.6); 0.7944 (2.6); 0.7343 (2.9);δ = 7.4171 (3.6); 7.3612 (5.3); 7.3314 (1.6); 7.3113 (2.5); 7.2938 (2.0); 7.2603 (80.8); 7.2195 (0.6); 7.2091 (0.6); 6.9945 (0.9); 6.9787 (3.4); 6.9604 (5.4); 6.9397 (3.0); 4.2811 (0.6); 4.1488 (0.7); 3.6257 (0.8); 2.9853 (0.6); 2.0420 (1.1); 1.9983 (11.0); 1.9853 (16.0); 1.9002 (11.7); 1.8483 (15.8); 1.8238 (6.4); 1.5541 (23.7); 1.4320 (1.0); 1.3885 (1.1); 1.3405 (3.1); 1.3279 (3.1); 1.2569 (0.6); 1.1931 (2.8); 1.1785 (2.7); 0.8099 (2.6); 0.7944 (2.6); 0.7343 (2.9);

0.7195 (2.9); -0.0002 (27.4) 0.7195 (2.9); -0.0002 (27.4)

1.71-109: 1 H-NMR(400.0 MHz, CDCI3):  1.71-109: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5182 (0.6); 7.4142 (4.2); 7.4124 (4.1); 7.3711 (0.5); 7.3552 (1.0); 7.3500 (0.9); 7.3391 (0.6); 7.3341 (2.0); 7.3290 (0.7); 7.3182 (0.9); 7.3130 (1.2); 7.2970 (0.6); 7.2593 (114.4); 6.9953 (0.8); 6.9877 (2.7); 6.9689 (3.1); 6.9668 (2.9); 6.9481 (2.4); 5.2983 (12.9); 2.9743 (0.7); 2.9460 (1.3); 2.9184 (0.7); 2.7656 (0.5); 2.3909 (0.9); 2.3802 (0.6); 2.3553 (1.1); 2.3309 (0.5); 2.0765 (0.7); 2.0625 (0.7); 2.0524 (0.7); 2.0392 (0.9); 2.0277 (0.7); 2.0064 (13.0); 2.0051δ = 7.5182 (0.6); 7.4142 (4.2); 7.4124 (4.1); 7.3711 (0.5); 7.3552 (1.0); 7.3500 (0.9); 7.3391 (0.6); 7.3341 (2.0); 7.3290 (0.7); 7.3182 (0.9); 7.3130 (1.2); 7.2970 (0.6); 7.2593 (114.4); 6.9953 (0.8); 6.9877 (2.7); 6.9689 (3.1); 6.9668 (2.9); 6.9481 (2.4); 5.2983 (12.9); 2.9743 (0.7); 2.9460 (1.3); 2.9184 (0.7); 2.7656 (0.5); 2.3909 (0.9); 2.3802 (0.6); 2.3553 (1.1); 2.3309 (0.5); 2.0765 (0.7); 2.0625 (0.7); 2.0524 (0.7); 2.0392 (0.9); 2.0277 (0.7); 2.0064 (13.0); 2.0051

(12.9); 1.8674 (16.0); 1.7932 (13.9); 1.5317 (13.8); 0.0080 (1.9); -0.0002 (65.2); -0.0085 (2.0) (12.9); 1.8674 (16.0); 1.7932 (13.9); 1.5317 (13.8); 0.0080 (1.9); -0.0002 (65.2); -0.0085 (2.0)

1.71-110: 1 H-NMR(400.0 MHz, CDCI3):  1.71-110: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3888 (1.0); 7.3790 (1.4); 7.3138 (0.7); 7.3095 (0.6); 7.2930 (0.5); 7.2603 (54.3); 6.9745 (1.2); 6.9556 (1.6); 6.9371 (1.0); 2.1698 (1.0); 2.1072 (0.6); 2.0816 (0.6); 1.9916 (7.9); 1.8304 (6.9); 1.8193 (6.2); 1.8151 (4.6); 1.5574δ = 7.3888 (1.0); 7.3790 (1.4); 7.3138 (0.7); 7.3095 (0.6); 7.2930 (0.5); 7.2603 (54.3); 6.9745 (1.2); 6.9556 (1.6); 6.9371 (1.0); 2.1698 (1.0); 2.1072 (0.6); 2.0816 (0.6); 1.9916 (7.9); 1.8304 (6.9); 1.8193 (6.2); 1.8151 (4.6); 1.5574

(16.0); 1.0115 (2.0); 0.9949 (1.9); 0.8790 (2.2); 0.8634 (2.2); 0.0080 (0.6); -0.0002 (20.3); -0.0085 (0.6) (16.0); 1.0115 (2.0); 0.9949 (1.9); 0.8790 (2.2); 0.8634 (2.2); 0.0080 (0.6); -0.0002 (20.3); -0.0085 (0.6)

1.71-111 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-111: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5191 (0.6); 7.4030 (2.5); 7.3594 (0.7); 7.3434 (1.4); 7.3383 (1.2); 7.3275 (0.8); 7.3224 (2.5); 7.3174 (1.0); 7.3065 (1.3); 7.3014 (1.6); 7.2853 (0.9); 7.2601 (110.2); 6.9962 (0.9); 6.9922 (0.5); 6.9814 (3.5); 6.9713 (0.7); 6.9627 (4.1); 6.9606 (3.8); 6.9522 (0.8); 6.9419 (3.1); 6.9307 (0.5); 3.6955 (0.5); 2.7879 (1.4); 2.7689 (1.1); 2.7483 (1.0); 2.7296 (0.6); 2.1697 (2.6); 2.0181 (1.0); 1.9978 (16.0); 1.9853 (2.0); 1.9668 (1.2); 1.8277 (12.9); 1.5507 (10.5); 0.0080 (1.3); -0.0002 (39.2); -0.0085 (1.5) 1.71-112: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5191 (0.6); 7.4030 (2.5); 7.3594 (0.7); 7.3434 (1.4); 7.3383 (1.2); 7.3275 (0.8); 7.3224 (2.5); 7.3174 (1.0); 7.3065 (1.3); 7.3014 (1.6); 7.2853 (0.9); 7.2601 (110.2); 6.9962 (0.9); 6.9922 (0.5); 6.9814 (3.5); 6.9713 (0.7); 6.9627 (4.1); 6.9606 (3.8); 6.9522 (0.8); 6.9419 (3.1); 6.9307 (0.5); 3.6955 (0.5); 2.7879 (1.4); 2.7689 (1.1); 2.7483 (1.0); 2.7296 (0.6); 2.1697 (2.6); 2.0181 (1.0); 1.9978 (16.0); 1.9853 (2.0); 1.9668 (1.2); 1.8277 (12.9); 1.5507 (10.5); 0.0080 (1.3); -0.0002 (39.2); -0.0085 (1.5) 1.71-112: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4131 (1.2); 7.3947 (1.2); 7.3511 (0.5); 7.3352 (1.1); 7.3300 (0.9); 7.3192 (0.6); 7.3141 (2.1); 7.3091 (0.7); 7.2982 (0.9); 7.2931 (1.2); 7.2772 (0.8); 7.2606 (84.3); 6.9744 (2.4); 6.9557 (2.8); 6.9536 (2.6); 6.9351 (2.1); 3.6875 (3.9); 3.6502 (4.2); 2.9332 (1.0); 2.9152 (1.6); 2.8977 (1.3); 2.8795 (0.6); 2.0444 (0.9); 2.0396 (0.6); 2.0262 (2.5); 2.0220 (1.5); 2.0080 (2.8); 1.9959 (11.1); 1.8539 (3.5); 1.8296 (3.9); 1.8108 (7.0); 1.5574 (16.0); 0.0080 (1.0); -δ = 7.4131 (1.2); 7.3947 (1.2); 7.3511 (0.5); 7.3352 (1.1); 7.3300 (0.9); 7.3192 (0.6); 7.3141 (2.1); 7.3091 (0.7); 7.2982 (0.9); 7.2931 (1.2); 7.2772 (0.8); 7.2606 (84.3); 6.9744 (2.4); 6.9557 (2.8); 6.9536 (2.6); 6.9351 (2.1); 3.6875 (3.9); 3.6502 (4.2); 2.9332 (1.0); 2.9152 (1.6); 2.8977 (1.3); 2.8795 (0.6); 2.0444 (0.9); 2.0396 (0.6); 2.0262 (2.5); 2.0220 (1.5); 2.0080 (2.8); 1.9959 (11.1); 1.8539 (3.5); 1.8296 (3.9); 1.8108 (7.0); 1.5574 (16.0); 0.0080 (1.0); -

0.0002 (30.2); -0.0085 (0.8) 0.0002 (30.2); -0.0085 (0.8)

1.71-113: 1 H-NMR(400.0 MHz, CDCI3):  1.71-113: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4043 (1.9); 7.3429 (0.7); 7.3375 (0.7); 7.3220 (1.3); 7.3009 (0.9); 7.2599 (43.1); 6.9803 (2.0); 6.9613 (2.7); 6.9422 (1.8); 3.7234 (0.5); 2.7980 (0.5); 2.6079 (0.6); 1.9960 (11.1); 1.9551 (0.5); 1.9417 (0.8); 1.9234 (0.9); 1.9098δ = 7.4043 (1.9); 7.3429 (0.7); 7.3375 (0.7); 7.3220 (1.3); 7.3009 (0.9); 7.2599 (43.1); 6.9803 (2.0); 6.9613 (2.7); 6.9422 (1.8); 3.7234 (0.5); 2.7980 (0.5); 2.6079 (0.6); 1.9960 (11.1); 1.9551 (0.5); 1.9417 (0.8); 1.9234 (0.9); 1.9098

(0.7); 1.8239 (16.0); 1.5487 (8.4); -0.0002 (14.6); -0.0016 (11.5) (0.7); 1.8239 (16.0); 1.5487 (8.4); -0.0002 (14.6); -0.0016 (11.5)

1.71-114: 1 H-NMR(400.0 MHz, CDCI3):  1.71-114: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5189 (0.8); 7.4207 (4.4); 7.3474 (0.7); 7.3300 (1.2); 7.3102 (0.9); 7.2600 (135.5); 6.9960 (0.9); 6.9873 (2.7); 6.9684 (3.4); 6.9480 (2.4); 5.2984 (1.0); 2.4325 (0.8); 2.4190 (0.7); 2.3998 (0.7); 2.3622 (0.6); 2.3276 (0.5); 2.2854 (1.0); 2.2562 (1.1); 2.2376 (0.8); 2.0549 (0.5); 2.0386 (0.9); 2.0250 (0.9); 2.0003 (16.0); 1.8333 (5.5); 1.8218 (14.8);δ = 7.5189 (0.8); 7.4207 (4.4); 7.3474 (0.7); 7.3300 (1.2); 7.3102 (0.9); 7.2600 (135.5); 6.9960 (0.9); 6.9873 (2.7); 6.9684 (3.4); 6.9480 (2.4); 5.2984 (1.0); 2.4325 (0.8); 2.4190 (0.7); 2.3998 (0.7); 2.3622 (0.6); 2.3276 (0.5); 2.2854 (1.0); 2.2562 (1.1); 2.2376 (0.8); 2.0549 (0.5); 2.0386 (0.9); 2.0250 (0.9); 2,0003 (16.0); 1.8333 (5.5); 1.8218 (14.8);

1.5471 (38.9); 1.2843 (0.6); 1.2568 (1.3); 0.0080 (1.4); -0.0002 (47.7); -0.0085 (1.4) 1.5471 (38.9); 1.2843 (0.6); 1.2568 (1.3); 0.0080 (1.4); -0.0002 (47.7); -0.0085 (1.4)

1.71-115: 1 H-NMR(400.0 MHz, CDCI3):  1.71-115: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4213 (2.0); 7.3440 (0.5); 7.3284 (1.0); 7.3120 (0.6); 7.3076 (0.7); 7.2598 (28.8); 6.9862 (1.4); 6.9670 (2.0); 6.9481 (1.3); 3.7515 (0.6); 2.9214 (0.7); 2.8926 (0.6); 2.2317 (0.6); 2.2166 (0.8); 2.1983 (1.2); 2.1810 (0.8); 2.1654δ = 7.4213 (2.0); 7.3440 (0.5); 7.3284 (1.0); 7.3120 (0.6); 7.3076 (0.7); 7.2598 (28.8); 6.9862 (1.4); 6.9670 (2.0); 6.9481 (1.3); 3.7515 (0.6); 2.9214 (0.7); 2.8926 (0.6); 2.2317 (0.6); 2.2166 (0.8); 2.1983 (1.2); 2.1810 (0.8); 2.1654

(0.7); 2.0078 (6.4); 1.8269 (16.0); 1.5457 (4.3); -0.0002 (9.7); -0.0019 (7.1) (0.7); 2.0078 (6.4); 1.8269 (16.0); 1.5457 (4.3); -0.0002 (9.7); -0.0019 (7.1)

1.71-116: 1 H-NMR(400.0 MHz, CDCI3):  1.71-116: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5182 (0.7); 7.3206 (1.6); 7.3186 (1.6); 7.3108 (0.9); 7.2943 (0.5); 7.2897 (0.6); 7.2738 (0.5); 7.2593 (107.8); 6.9952 (0.8); 6.9795 (1.0); 6.9608 (1.1); 6.9400 (0.9); 5.2983 (0.8); 1.9861 (4.7); 1.9846 (4.6); 1.8793 (0.6); 1.8251δ = 7.5182 (0.7); 7.3206 (1.6); 7.3186 (1.6); 7.3108 (0.9); 7.2943 (0.5); 7.2897 (0.6); 7.2738 (0.5); 7.2593 (107.8); 6.9952 (0.8); 6.9795 (1.0); 6.9608 (1.1); 6.9400 (0.9); 5.2983 (0.8); 1.9861 (4.7); 1.9846 (4.6); 1.8793 (0.6); 1.8251

(16.0); 1.2561 (0.7); 1.1306 (0.6); 0.8152 (0.6); 0.0080 (1.2); -0.0002 (44.1); -0.0085 (1.4) (16.0); 1.2561 (0.7); 1.1306 (0.6); 0.8152 (0.6); 0.0080 (1.2); -0.0002 (44.1); -0.0085 (1.4)

1.71-117: 1 H-NMR(400.0 MHz, CDCI3):  1.71-117: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5192 (0.6); 7.3955 (5.4); 7.3426 (0.7); 7.3374 (0.7); 7.3216 (1.4); 7.3162 (0.7); 7.3102 (0.8); 7.3061 (0.9); 7.3006 (0.9); 7.2881 (0.6); 7.2603 (107.0); 6.9963 (0.7); 6.9829 (1.9); 6.9723 (1.3); 6.9643 (2.4); 6.9537 (1.6); 6.9438 (1.8); 6.9333 (0.9); 3.7818 (0.5); 3.7502 (0.6); 3.6537 (1.0); 3.6456 (0.7); 3.6317 (0.7); 3.6236 (0.6); 3.6098 (0.6); 3.5911 (0.7); 3.5859 (0.7); 3.5676 (0.6); 3.3042 (0.9); 3.2717 (0.8); 3.1793 (7.4); 3.0727 (16.0); 2.9663 (1.1); 2.9361 (1.2); 2.3003 (1.8); 2.2708 (1.6); 1.9887 (13.3); 1.9658 (0.5); 1.9562 (0.6); 1.9464 (0.8); 1.9333 (0.7); 1.9275 (0.7); 1.9189 (0.6); 1.8404 (11.0); 1.8291 (6.8); 1.8193 (14.1); 1.6020 (0.8); 1.5791 (1.2); 1.5604 (7.0); 1.5469 (1.0); 1.5183δ = 7.5192 (0.6); 7.3955 (5.4); 7.3426 (0.7); 7.3374 (0.7); 7.3216 (1.4); 7.3162 (0.7); 7.3102 (0.8); 7.3061 (0.9); 7.3006 (0.9); 7.2881 (0.6); 7.2603 (107.0); 6.9963 (0.7); 6.9829 (1.9); 6.9723 (1.3); 6.9643 (2.4); 6.9537 (1.6); 6.9438 (1.8); 6.9333 (0.9); 3.7818 (0.5); 3.7502 (0.6); 3.6537 (1.0); 3.6456 (0.7); 3.6317 (0.7); 3.6236 (0.6); 3.6098 (0.6); 3.5911 (0.7); 3.5859 (0.7); 3.5676 (0.6); 3.3042 (0.9); 3.2717 (0.8); 3.1793 (7.4); 3.0727 (16.0); 2.9663 (1.1); 2.9361 (1.2); 2.3003 (1.8); 2.2708 (1.6); 1.9887 (13.3); 1.9658 (0.5); 1.9562 (0.6); 1.9464 (0.8); 1.9333 (0.7); 1.9275 (0.7); 1.9189 (0.6); 1.8404 (11.0); 1.8291 (6.8); 1.8193 (14.1); 1.6020 (0.8); 1.5791 (1.2); 1.5604 (7.0); 1.5469 (1.0); 1.5183

(0.6); 1.2860 (6.3); 1.1377 (12.8); 0.0079 (1.1); -0.0002 (37.2); -0.0085 (1.1) (0.6); 1.2860 (6.3); 1.1377 (12.8); 0.0079 (1.1); -0.0002 (37.2); -0.0085 (1.1)

1.71-118: 1 H-NMR(400.0 MHz, CDCI3):  1.71-118: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5196 (0.6); 7.4065 (2.7); 7.3952 (1.5); 7.3385 (0.8); 7.3335 (0.9); 7.3175 (1.6); 7.3015 (0.9); 7.2966 (1.0); 7.2802 (0.6); 7.2607 (114.0); 6.9967 (0.6); 6.9767 (3.1); 6.9670 (0.6); 6.9581 (3.6); 6.9560 (3.4); 6.9476 (0.6); 6.9375 (2.7); 3.9655 (0.6); 3.9340 (0.7); 3.6755 (5.4); 3.6450 (11.6); 3.6270 (0.6); 3.6186 (0.5); 3.5435 (0.9); 3.5122 (0.5); 3.4407 (0.7); 3.4094 (0.6); 3.3351 (1.2); 3.3071 (1.3); 2.3186 (1.4); 2.2902 (1.3); 2.2482 (0.5); 2.2298 (1.0); 2.2115 (0.7); 2.1981 (0.7); 2.1699 (8.3); 1.9941 (16.0); 1.8627 (8.2); 1.8205 (5.3); 1.8147 (5.7); 1.8013 (8.5); 1.6562 (0.6); 1.6362 (0.9); 1.6248 (0.5); 1.6158 (0.5); 1.6049 (0.8); 1.5837 (0.7); 1.5611 (6.0); 1.2732 (4.5); 1.1451 (9.2); 0.0080δ = 7.5196 (0.6); 7.4065 (2.7); 7.3952 (1.5); 7.3385 (0.8); 7.3335 (0.9); 7.3175 (1.6); 7.3015 (0.9); 7.2966 (1.0); 7.2802 (0.6); 7.2607 (114.0); 6.9967 (0.6); 6.9767 (3.1); 6.9670 (0.6); 6.9581 (3.6); 6.9560 (3.4); 6.9476 (0.6); 6.9375 (2.7); 3.9655 (0.6); 3.9340 (0.7); 3.6755 (5.4); 3.6450 (11.6); 3.6270 (0.6); 3.6186 (0.5); 3.5435 (0.9); 3.5122 (0.5); 3.4407 (0.7); 3.4094 (0.6); 3.3351 (1.2); 3.3071 (1.3); 2.3186 (1.4); 2.2902 (1.3); 2.2482 (0.5); 2.2298 (1.0); 2.2115 (0.7); 2.1981 (0.7); 2.1699 (8.3); 1.9941 (16.0); 1.8627 (8.2); 1.8205 (5.3); 1.8147 (5.7); 1.8013 (8.5); 1.6562 (0.6); 1.6362 (0.9); 1.6248 (0.5); 1.6158 (0.5); 1.6049 (0.8); 1.5837 (0.7); 1.5611 (6.0); 1.2732 (4.5); 1.1451 (9.2); 0.0080

(1.2) ; -0.0002 (40.7); -0.0085 (1.2) (1.2); -0.0002 (40.7); -0.0085 (1.2)

1.71-119: 1 H-NMR(400.0 MHz, CDCI3):  1.71-119: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4066 (2.8); 7.3945 (1.8); 7.3479 (0.6); 7.3318 (1.2); 7.3162 (1.0); 7.3119 (1.0); 7.2960 (0.6); 7.2618 (54.0); 6.9975 (0.8); 6.9921 (1.4); 6.9733 (2.8); 6.9545 (2.4); 6.9363 (0.8); 4.6568 (1.6); 4.6417 (1.8); 4.4976 (1.9); 4.4816δ = 7.4066 (2.8); 7.3945 (1.8); 7.3479 (0.6); 7.3318 (1.2); 7.3162 (1.0); 7.3119 (1.0); 7.2960 (0.6); 7.2618 (54.0); 6.9975 (0.8); 6.9921 (1.4); 6.9733 (2.8); 6.9545 (2.4); 6.9363 (0.8); 4.6568 (1.6); 4.6417 (1.8); 4.4976 (1.9); 4.4816

(2.3) ; 4.4746 (3.0); 4.4590 (3.4); 4.3957 (3.2); 4.3805 (2.3); 3.7574 (2.9); 3.5484 (1.3); 3.5305 (2.3); 3.5126 (1.3); 3.4864 (0.6); 2.8452 (4.7); 2.6515 (0.8); 2.6347 (1.5); 2.6177 (0.8); 2.0629 (0.9); 2.0460 (1.7); 2.0254 (2.2); 2.0085(2.3); 4.4746 (3.0); 4.4590 (3.4); 4.3957 (3.2); 4.3805 (2.3); 3.7574 (2.9); 3.5484 (1.3); 3.5305 (2.3); 3.5126 (1.3); 3.4864 (0.6); 2.8452 (4.7); 2.6515 (0.8); 2.6347 (1.5); 2.6177 (0.8); 2.0629 (0.9); 2.0460 (1.7); 2.0254 (2.2); 2.0085

(10.3); 1.9941 (5.8); 1.8367 (16.0); 1.8041 (9.4); 1.5865 (3.4); 0.0080 (0.7); -0.0002 (21.0); -0.0085 (0.7) (10.3); 1.9941 (5.8); 1.8367 (16.0); 1.8041 (9.4); 1.5865 (3.4); 0.0080 (0.7); -0.0002 (21.0); -0.0085 (0.7)

1.71-120: 1 H-NMR(400.0 MHz, CDCI3):  1.71-120: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4415 (1.6); 7.4394 (1.6); 7.3445 (0.7); 7.2594 (27.3); 7.0017 (1.0); 6.9830 (1.0); 6.9808 (1.0); 6.9621 (0.8);δ = 7.4415 (1.6); 7.4394 (1.6); 7.3445 (0.7); 7.2594 (27.3); 7.0017 (1.0); 6.9830 (1.0); 6.9808 (1.0); 6.9621 (0.8);

5.2981 (7.2); 2.0212 (4.3); 2.0196 (4.3); 1.8384 (16.0); 1.5362 (0.8); -0.0002 (10.3) 5.2981 (7.2); 2.0212 (4.3); 2.0196 (4.3); 1.8384 (16.0); 1.5362 (0.8); -0.0002 (10.3)

1.71-121 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-121: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5185 (0.6); 7.4262 (5.8); 7.4242 (5.7); 7.3713 (0.7); 7.3553 (1.4); 7.3501 (1.1); 7.3394 (0.9); 7.3342 (2.6); 7.3291 (1.0); 7.3184 (1.2); 7.3132 (1.6); 7.2972 (0.8); 7.2596 (101.9); 6.9956 (0.8); 6.9892 (3.4); 6.9703 (4.0); 6.9683 (3.6); 6.9495 (3.0); 5.2983 (8.3); 3.9170 (0.9); 3.9024 (0.9); 3.8652 (0.8); 3.8468 (0.8); 3.1281 (0.7); 3.1002 (0.8); 2.9717 (1.2); 2.7815 (0.6); 2.7642 (0.7); 2.0019 (16.0); 2.0004 (15.7); 1.8426 (7.6); 1.8157 (7.8); 1.5429 (3.5); 0.0079δ = 7.5185 (0.6); 7.4262 (5.8); 7.4242 (5.7); 7.3713 (0.7); 7.3553 (1.4); 7.3501 (1.1); 7.3394 (0.9); 7.3342 (2.6); 7.3291 (1.0); 7.3184 (1.2); 7.3132 (1.6); 7.2972 (0.8); 7.2596 (101.9); 6.9956 (0.8); 6.9892 (3.4); 6.9703 (4.0); 6.9683 (3.6); 6.9495 (3.0); 5.2983 (8.3); 3.9170 (0.9); 3.9024 (0.9); 3.8652 (0.8); 3.8468 (0.8); 3.1281 (0.7); 3.1002 (0.8); 2.9717 (1.2); 2.7815 (0.6); 2.7642 (0.7); 2.0019 (16.0); 2,0004 (15.7); 1.8426 (7.6); 1.8157 (7.8); 1.5429 (3.5); 0.0079

(1.2); -0.0002 (39.9); -0.0085 (1.6) (1.2); -0.0002 (39.9); -0.0085 (1.6)

1.71-122: 1 H-NMR(400.0 MHz, CDCI3):  1.71-122: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4330 (1.6); 7.4310 (1.6); 7.2884 (0.8); 7.2672 (0.8); 7.2593 (46.2); 6.9489 (0.9); 6.9299 (1.0); 6.9281 (0.9); 6.9091 (0.8); 3.7036 (0.7); 3.6850 (0.8); 3.6661 (0.7); 3.4260 (0.8); 3.4087 (1.7); 3.3915 (0.9); 2.1481 (0.8); 2.1291δ = 7.4330 (1.6); 7.4310 (1.6); 7.2884 (0.8); 7.2672 (0.8); 7.2593 (46.2); 6.9489 (0.9); 6.9299 (1.0); 6.9281 (0.9); 6.9091 (0.8); 3.7036 (0.7); 3.6850 (0.8); 3.6661 (0.7); 3.4260 (0.8); 3.4087 (1.7); 3.3915 (0.9); 2.1481 (0.8); 2.1291

(0.9); 2.1110 (0.8); 1.9980 (4.5); 1.9964 (4.4); 1.8577 (16.0); 1.5397 (5.5); 0.0080 (0.5); -0.0002 (17.4) (0.9); 2.1110 (0.8); 1.9980 (4.5); 1.9964 (4.4); 1.8577 (16.0); 1.5397 (5.5); 0.0080 (0.5); -0.0002 (17.4)

1.71-123: 1 H-NMR(400.0 MHz, CDCI3):  1.71-123: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3999 (1.5); 7.3982 (1.4); 7.3244 (0.8); 7.3034 (0.5); 7.2601 (34.2); 6.9853 (1.0); 6.9666 (1.2); 6.9645 (1.0); 6.9458 (0.9); 4.2174 (2.4); 3.1873 (0.5); 3.1713 (1.1); 3.1553 (0.6); 2.9636 (0.9); 2.8685 (1.0); 2.8526 (1.7); 2.8366δ = 7.3999 (1.5); 7.3982 (1.4); 7.3244 (0.8); 7.3034 (0.5); 7.2601 (34.2); 6.9853 (1.0); 6.9666 (1.2); 6.9645 (1.0); 6.9458 (0.9); 4.2174 (2.4); 3.1873 (0.5); 3.1713 (1.1); 3.1553 (0.6); 2.9636 (0.9); 2.8685 (1.0); 2.8526 (1.7); 2.8366

(0.9); 1.9990 (4.8); 1.9976 (4.7); 1.8465 (16.0); 1.5471 (1.1); -0.0002 (12.8); -0.0085 (0.6) (0.9); 1.9990 (4.8); 1.9976 (4.7); 1.8465 (16.0); 1.5471 (1.1); -0.0002 (12.8); -0.0085 (0.6)

1.71-124: 1 H-NMR(400.0 MHz, CDCI3):  1.71-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3358 (1.6); 7.3337 (1.6); 7.3320 (1.0); 7.3108 (0.8); 7.2606 (20.0); 6.9775 (0.9); 6.9587 (1.0); 6.9566 (0.9); 6.9379 (0.8); 1.9893 (4.4); 1.9876 (4.3); 1.8282 (16.0); 1.5604 (3.1); 1.5107 (0.6); -0.0002 (6.9) 1.71-125: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3358 (1.6); 7.3337 (1.6); 7.3320 (1.0); 7.3108 (0.8); 7.2606 (20.0); 6.9775 (0.9); 6.9587 (1.0); 6.9566 (0.9); 6.9379 (0.8); 1.9893 (4.4); 1.9876 (4.3); 1.8282 (16.0); 1.5604 (3.1); 1.5107 (0.6); -0.0002 (6.9) 1.71-125: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3448 (4.2); 7.3320 (1.3); 7.3268 (1.1); 7.3161 (0.8); 7.3110 (2.4); 7.3058 (0.9); 7.2951 (1.0); 7.2900 (1.4); 7.2740 (0.8); 7.2617 (43.3); 6.9743 (3.0); 6.9645 (0.6); 6.9556 (3.4); 6.9536 (3.2); 6.9450 (0.6); 6.9349 (2.6); 5.2983 (2.0); 4.0967 (1.0); 1.9896 (15.3); 1.9881 (15.0); 1.9539 (0.6); 1.8904 (0.5); 1.8379 (12.4); 1.8243 (16.0); 1.5751δ = 7.3448 (4.2); 7.3320 (1.3); 7.3268 (1.1); 7.3161 (0.8); 7.3110 (2.4); 7.3058 (0.9); 7.2951 (1.0); 7.2900 (1.4); 7.2740 (0.8); 7.2617 (43.3); 6.9743 (3.0); 6.9645 (0.6); 6.9556 (3.4); 6.9536 (3.2); 6.9450 (0.6); 6.9349 (2.6); 5.2983 (2.0); 4.0967 (1.0); 1.9896 (15.3); 1.9881 (15.0); 1.9539 (0.6); 1.8904 (0.5); 1.8379 (12.4); 1.8243 (16.0); 1.5751

(3.4) ; 1.5554 (0.7); 1.5302 (0.7); 1.2518 (0.8); 1.2332 (1.3); 1.2098 (1.8); -0.0002 (16.0) (3.4); 1.5554 (0.7); 1.5302 (0.7); 1.2518 (0.8); 1.2332 (1.3); 1.2098 (1.8); -0.0002 (16.0)

1.71-126: 1 H-NMR(400.0 MHz, CDCI3):  1.71-126: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3468 (0.7); 7.3309 (1.2); 7.3257 (1.1); 7.3151 (1.2); 7.3099 (2.3); 7.3048 (1.1); 7.2940 (0.9); 7.2889 (1.2); 7.2731 (0.7); 7.2604 (57.0); 6.9777 (2.4); 6.9590 (2.7); 6.9569 (2.5); 6.9382 (2.0); 5.2982 (2.0); 2.7076 (0.6); 1.9861 (12.1); 1.9844 (12.2); 1.8609 (0.5); 1.8327 (16.0); 1.7957 (1.7); 1.5555 (11.5); 1.5006 (1.0); 1.1499 (1.0); 1.1355δ = 7.3468 (0.7); 7.3309 (1.2); 7.3257 (1.1); 7.3151 (1.2); 7.3099 (2.3); 7.3048 (1.1); 7.2940 (0.9); 7.2889 (1.2); 7.2731 (0.7); 7.2604 (57.0); 6.9777 (2.4); 6.9590 (2.7); 6.9569 (2.5); 6.9382 (2.0); 5.2982 (2.0); 2.7076 (0.6); 1.9861 (12.1); 1.9844 (12.2); 1.8609 (0.5); 1.8327 (16.0); 1.7957 (1.7); 1.5555 (11.5); 1.5006 (1.0); 1.1499 (1.0); 1.1355

(1.0); 0.0080 (0.6); -0.0002 (22.3); -0.0085 (0.7) (1.0); 0.0080 (0.6); -0.0002 (22.3); -0.0085 (0.7)

1.71-127: 1 H-NMR(400.0 MHz, CDCI3):  1.71-127: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4082 (1.8); 7.4062 (1.8); 7.3209 (0.8); 7.2998 (0.5); 7.2602 (22.4); 6.9841 (1.1); 6.9653 (1.2); 6.9633 (1.2); 6.9446 (0.9); 5.2983 (3.1); 4.6726 (1.4); 4.6550 (1.6); 4.3725 (2.2); 4.3692 (1.2); 4.3579 (1.1); 4.3545 (2.0); 2.8122 (0.6); 2.7989 (0.8); 2.7854 (0.6); 2.0696 (0.8); 2.0549 (1.1); 2.0394 (1.0); 2.0022 (5.0); 2.0007 (5.0); 1.8356 (16.0);δ = 7.4082 (1.8); 7.4062 (1.8); 7.3209 (0.8); 7.2998 (0.5); 7.2602 (22.4); 6.9841 (1.1); 6.9653 (1.2); 6.9633 (1.2); 6.9446 (0.9); 5.2983 (3.1); 4.6726 (1.4); 4.6550 (1.6); 4.3725 (2.2); 4.3692 (1.2); 4.3579 (1.1); 4.3545 (2.0); 2.8122 (0.6); 2.7989 (0.8); 2.7854 (0.6); 2.0696 (0.8); 2.0549 (1.1); 2.0394 (1.0); 2.0022 (5.0); 2,0007 (5.0); 1.8356 (16.0);

1.6468 (0.6); 1.6318 (0.9); 1.6165 (0.6); 1.5496 (2.6); 1.1827 (0.6); 1.1690 (0.8); 1.1547 (0.6); -0.0002 (9.2) 1.6468 (0.6); 1.6318 (0.9); 1.6165 (0.6); 1.5496 (2.6); 1.1827 (0.6); 1.1690 (0.8); 1.1547 (0.6); -0.0002 (9.2)

1.71-128: 1 H-NMR(400.0 MHz, CDCI3):  1.71-128: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3452 (4.1); 7.3323 (1.3); 7.3270 (1.0); 7.3164 (0.8); 7.3112 (2.2); 7.3061 (0.8); 7.2951 (1.0); 7.2902 (1.4); 7.2744 (0.8); 7.2619 (41.2); 6.9746 (2.9); 6.9647 (0.6); 6.9559 (3.4); 6.9539 (3.2); 6.9453 (0.6); 6.9352 (2.5); 4.0894 (1.0); 1.9896 (14.8); 1.9881 (15.3); 1.9571 (0.6); 1.8377 (12.3); 1.8240 (16.0); 1.5818 (3.9); 1.5588 (0.7); 1.5291δ = 7.3452 (4.1); 7.3323 (1.3); 7.3270 (1.0); 7.3164 (0.8); 7.3112 (2.2); 7.3061 (0.8); 7.2951 (1.0); 7.2902 (1.4); 7.2744 (0.8); 7.2619 (41.2); 6.9746 (2.9); 6.9647 (0.6); 6.9559 (3.4); 6.9539 (3.2); 6.9453 (0.6); 6.9352 (2.5); 4.0894 (1.0); 1.9896 (14.8); 1.9881 (15.3); 1.9571 (0.6); 1.8377 (12.3); 1.8240 (16.0); 1.5818 (3.9); 1.5588 (0.7); 1.5291

(0.7); 1.2065 (1.8); -0.0002 (15.6); -0.0085 (0.6) (0.7); 1.2065 (1.8); -0.0002 (15.6); -0.0085 (0.6)

1.71-129: 1 H-NMR(400.0 MHz, CDCI3):  1.71-129: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3476 (0.6); 7.3317 (1.4); 7.3225 (4.5); 7.3206 (4.4); 7.3160 (1.1); 7.3107 (2.5); 7.3056 (0.8); 7.2952 (0.9); 7.2897 (1.5); 7.2739 (0.8); 7.2604 (58.1); 6.9793 (2.9); 6.9778 (2.0); 6.9733 (0.5); 6.9621 (2.2); 6.9605 (3.1); 6.9584 (2.8); 6.9498 (0.5); 6.9397 (2.4); 5.2982 (1.8); 1.9884 (12.8); 1.9867 (12.9); 1.8313 (16.0); 1.8204 (13.7); 1.7248 (0.6); 1.6933 (0.6); 1.5573 (9.8); 1.0046 (0.6); 0.9954 (0.6); 0.9761 (0.5); 0.9671 (0.5); 0.0080 (0.6); -0.0002 (23.7); -δ = 7.3476 (0.6); 7.3317 (1.4); 7.3225 (4.5); 7.3206 (4.4); 7.3160 (1.1); 7.3107 (2.5); 7.3056 (0.8); 7.2952 (0.9); 7.2897 (1.5); 7.2739 (0.8); 7.2604 (58.1); 6.9793 (2.9); 6.9778 (2.0); 6.9733 (0.5); 6.9621 (2.2); 6.9605 (3.1); 6.9584 (2.8); 6.9498 (0.5); 6.9397 (2.4); 5.2982 (1.8); 1.9884 (12.8); 1.9867 (12.9); 1.8313 (16.0); 1.8204 (13.7); 1.7248 (0.6); 1.6933 (0.6); 1.5573 (9.8); 1.0046 (0.6); 0.9954 (0.6); 0.9761 (0.5); 0.9671 (0.5); 0.0080 (0.6); -0.0002 (23.7); -

0.0085 (0.7) 0.0085 (0.7)

1.71-130: 1 H-NMR(400.0 MHz, CDCI3):  1.71-130: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3472 (5.3); 7.3457 (5.3); 7.3346 (1.8); 7.3292 (1.3); 7.3187 (1.0); 7.3135 (3.0); 7.3084 (1.0); 7.2974 (1.4); 7.2925 (1.8); 7.2767 (1.0); 7.2615 (49.5); 6.9899 (0.5); 6.9791 (3.8); 6.9731 (0.7); 6.9691 (0.7); 6.9603 (4.5); 6.9583 (4.2); 6.9497 (0.7); 6.9395 (3.4); 3.3586 (0.7); 3.2016 (0.6); 2.8485 (0.6); 2.8226 (0.9); 2.7964 (0.5); 1.9942 (16.0);δ = 7.3472 (5.3); 7.3457 (5.3); 7.3346 (1.8); 7.3292 (1.3); 7.3187 (1.0); 7.3135 (3.0); 7.3084 (1.0); 7.2974 (1.4); 7.2925 (1.8); 7.2767 (1.0); 7.2615 (49.5); 6.9899 (0.5); 6.9791 (3.8); 6.9731 (0.7); 6.9691 (0.7); 6.9603 (4.5); 6.9583 (4.2); 6.9497 (0.7); 6.9395 (3.4); 3.3586 (0.7); 3.2016 (0.6); 2.8485 (0.6); 2.8226 (0.9); 2.7964 (0.5); 1.9942 (16.0);

1.8440 (7.6); 1.8178 (8.6); 1.5784 (4.8); 1.4185 (0.6); 0.0080 (0.6); -0.0002 (19.1); -0.0085 (0.6) 1.8440 (7.6); 1.8178 (8.6); 1.5784 (4.8); 1.4185 (0.6); 0.0080 (0.6); -0.0002 (19.1); -0.0085 (0.6)

1.71-131 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-131: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5839 (0.6); 7.5524 (0.6); 7.5185 (1.0); 7.4690 (0.8); 7.4671 (0.7); 7.3919 (3.7); 7.3900 (3.6); 7.3431 (0.8); 7.3377 (0.8); 7.3272 (0.6); 7.3222 (1.6); 7.3170 (0.7); 7.3058 (0.9); 7.3010 (1.0); 7.2850 (0.7); 7.2826 (0.6); 7.2723 (0.8); 7.2715 (0.8); 7.2690 (1.1); 7.2596 (172.2); 6.9957 (1.2); 6.9817 (2.1); 6.9759 (0.9); 6.9629 (2.5); 6.9608 (2.4); 6.9422 (1.8); 4.3958 (0.6); 4.3642 (0.6); 2.4168 (2.1); 2.3995 (4.1); 2.3823 (2.2); 2.0194 (0.9); 2.0007 (11.3); 1.9991 (10.6); 1.9810 (0.5); 1.8634 (1.0); 1.8360 (16.0); 1.8073 (7.5); 1.5379 (27.8); 0.0079 (2.1); -0.0002 (63.4); -0.0085δ = 7.5839 (0.6); 7.5524 (0.6); 7.5185 (1.0); 7.4690 (0.8); 7.4671 (0.7); 7.3919 (3.7); 7.3900 (3.6); 7.3431 (0.8); 7.3377 (0.8); 7.3272 (0.6); 7.3222 (1.6); 7.3170 (0.7); 7.3058 (0.9); 7.3010 (1.0); 7.2850 (0.7); 7.2826 (0.6); 7.2723 (0.8); 7.2715 (0.8); 7.2690 (1.1); 7.2596 (172.2); 6.9957 (1.2); 6.9817 (2.1); 6.9759 (0.9); 6.9629 (2.5); 6.9608 (2.4); 6.9422 (1.8); 4.3958 (0.6); 4.3642 (0.6); 2.4168 (2.1); 2.3995 (4.1); 2.3823 (2.2); 2.0194 (0.9); 2,0007 (11.3); 1.9991 (10.6); 1.9810 (0.5); 1.8634 (1.0); 1.8360 (16.0); 1.8073 (7.5); 1.5379 (27.8); 0.0079 (2.1); -0.0002 (63.4); -0.0085

(1 -7) (1 -7)

1.71-132: 1 H-NMR(400.0 MHz, CDCI3):  1.71-132: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3391 (0.6); 7.3337 (0.5); 7.3180 (1.2); 7.3129 (0.5); 7.2975 (2.2); 7.2614 (20.1); 6.9805 (1.5); 6.9617 (1.8); 6.9598 (1.8); 6.9409 (1.3); 4.3701 (0.8); 4.2781 (3.4); 4.2633 (2.6); 1.9874 (7.2); 1.8333 (16.0); 1.7833 (1.2); 1.7684δ = 7.3391 (0.6); 7.3337 (0.5); 7.3180 (1.2); 7.3129 (0.5); 7.2975 (2.2); 7.2614 (20.1); 6.9805 (1.5); 6.9617 (1.8); 6.9598 (1.8); 6.9409 (1.3); 4.3701 (0.8); 4.2781 (3.4); 4.2633 (2.6); 1.9874 (7.2); 1.8333 (16.0); 1.7833 (1.2); 1.7684

(1.5) ; 1.7530 (1.3); 1.5782 (1.8); 1.2282 (0.5); -0.0002 (7.6) (1.5); 1.7530 (1.3); 1.5782 (1.8); 1.2282 (0.5); -0.0002 (7.6)

1.71-133: 1 H-NMR(400.0 MHz, CDCI3):  1.71-133: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3420 (2.1); 7.3400 (2.1); 7.3357 (0.6); 7.3145 (0.9); 7.2935 (0.6); 7.2602 (38.1); 6.9775 (1.2); 6.9588 (1.3); 6.9567 (1.2); 6.9380 (1.0); 4.1361 (1.0); 4.1183 (3.1); 4.1005 (3.2); 4.0826 (1.0); 2.4005 (0.6); 1.9916 (5.5); 1.9901δ = 7.3420 (2.1); 7.3400 (2.1); 7.3357 (0.6); 7.3145 (0.9); 7.2935 (0.6); 7.2602 (38.1); 6.9775 (1.2); 6.9588 (1.3); 6.9567 (1.2); 6.9380 (1.0); 4.1361 (1.0); 4.1183 (3.1); 4.1005 (3.2); 4.0826 (1.0); 2.4005 (0.6); 1.9916 (5.5); 1.9901

(5.5); 1.8294 (16.0); 1.5477 (6.4); 1.2449 (3.5); 1.2271 (7.3); 1.2093 (3.4); -0.0002 (13.8) (5.5); 1.8294 (16.0); 1.5477 (6.4); 1.2449 (3.5); 1.2271 (7.3); 1.2093 (3.4); -0.0002 (13.8)

1.71-134: 1 H-NMR(400.0 MHz, CDCI3):  1.71-134: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3289 (2.2); 7.3270 (2.4); 7.3112 (0.9); 7.2902 (0.6); 7.2603 (23.6); 6.9783 (1.2); 6.9595 (1.3); 6.9574 (1.2); 6.9387 (1.0); 2.5826 (0.8); 2.5774 (0.8); 2.5509 (0.5); 1.9886 (5.5); 1.9870 (5.6); 1.8261 (16.0); 1.5557 (5.1); 0.8754δ = 7.3289 (2.2); 7.3270 (2.4); 7.3112 (0.9); 7.2902 (0.6); 7.2603 (23.6); 6.9783 (1.2); 6.9595 (1.3); 6.9574 (1.2); 6.9387 (1.0); 2.5826 (0.8); 2.5774 (0.8); 2.5509 (0.5); 1.9886 (5.5); 1.9870 (5.6); 1.8261 (16.0); 1.5557 (5.1); 0.8754

(3.4); 0.8594 (3.3); -0.0002 (9.0) (3.4); 0.8594 (3.3); -0.0002 (9.0)

1.71-135: 1 H-NMR(400.0 MHz, CDCI3):  1.71-135: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3367 (1.8); 7.3348 (2.1); 7.3141 (0.8); 7.2931 (0.5); 7.2602 (26.7); 6.9789 (1.0); 6.9601 (1.1); 6.9580 (1.0); 6.9394 (0.8); 3.2969 (13.2); 3.2909 (0.7); 1.9854 (4.6); 1.9838 (4.6); 1.8301 (16.0); 1.5503 (3.8); -0.0002 (9.9) 1.71-136: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3367 (1.8); 7.3348 (2.1); 7.3141 (0.8); 7.2931 (0.5); 7.2602 (26.7); 6.9789 (1.0); 6.9601 (1.1); 6.9580 (1.0); 6.9394 (0.8); 3.2969 (13.2); 3.2909 (0.7); 1.9854 (4.6); 1.9838 (4.6); 1.8301 (16.0); 1.5503 (3.8); -0.0002 (9.9) 1.71-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3629 (2.1); 7.3609 (2.1); 7.3518 (0.5); 7.3307 (1.0); 7.3097 (0.6); 7.2604 (27.3); 6.9900 (1.2); 6.9710 (1.3); 6.9690 (1.2); 6.9502 (1.0); 5.2984 (2.4); 2.7476 (0.5); 2.0006 (5.4); 1.9989 (5.4); 1.8319 (16.0); 1.5502 (4.6); -0.0002δ = 7.3629 (2.1); 7.3609 (2.1); 7.3518 (0.5); 7.3307 (1.0); 7.3097 (0.6); 7.2604 (27.3); 6.9900 (1.2); 6.9710 (1.3); 6.9690 (1.2); 6.9502 (1.0); 5.2984 (2.4); 2.7476 (0.5); 2,0006 (5.4); 1.9989 (5.4); 1.8319 (16.0); 1.5502 (4.6); -0.0002

(10.9) (10.9)

1.71-137: 1 H-NMR(400.0 MHz, CDCI3):  1.71-137: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3744 (1.6); 7.3724 (1.6); 7.3299 (0.7); 7.2599 (26.3); 6.9904 (0.9); 6.9715 (1.0); 6.9694 (1.0); 6.9506 (0.8);δ = 7.3744 (1.6); 7.3724 (1.6); 7.3299 (0.7); 7.2599 (26.3); 6.9904 (0.9); 6.9715 (1.0); 6.9694 (1.0); 6.9506 (0.8);

5.2983 (0.8); 1.9978 (4.3); 1.9961 (4.4); 1.8456 (16.0); 1.5444 (4.3); -0.0002 (10.0) 5.2983 (0.8); 1.9978 (4.3); 1.9961 (4.4); 1.8456 (16.0); 1.5444 (4.3); -0.0002 (10.0)

1.71-138: 1 H-NMR(400.0 MHz, CDCI3):  1.71-138: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4252 (1.7); 7.4232 (1.7); 7.3262 (0.8); 7.2601 (33.5); 6.9810 (1.0); 6.9620 (1.0); 6.9600 (1.0); 6.9412 (0.8);δ = 7.4252 (1.7); 7.4232 (1.7); 7.3262 (0.8); 7.2601 (33.5); 6.9810 (1.0); 6.9620 (1.0); 6.9600 (1.0); 6.9412 (0.8);

1.9949 (4.3); 1.9932 (4.3); 1.8833 (16.0); 1.5444 (3.7); -0.0002 (13.6) 1.9949 (4.3); 1.9932 (4.3); 1.8833 (16.0); 1.5444 (3.7); -0.0002 (13.6)

1.71-139: 1 H-NMR(400.0 MHz, CDCI3):  1.71-139: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3339 (1.8); 7.3319 (2.0); 7.3263 (0.9); 7.3053 (0.6); 7.2595 (76.1); 6.9887 (1.0); 6.9698 (1.1); 6.9678 (1.0); 6.9490 (0.8); 5.2983 (1.6); 4.3998 (1.2); 4.3690 (3.6); 1.9910 (4.7); 1.9895 (4.6); 1.8221 (16.0); 1.5414 (3.2); 0.0079 (0.8); -0.0002 (28.0); -0.0085 (0.9) 1.71-140: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3339 (1.8); 7.3319 (2.0); 7.3263 (0.9); 7.3053 (0.6); 7.2595 (76.1); 6,987 (1.0); 6.9698 (1.1); 6.9678 (1.0); 6.9490 (0.8); 5.2983 (1.6); 4.3998 (1.2); 4.3690 (3.6); 1.9910 (4.7); 1.9895 (4.6); 1.8221 (16.0); 1.5414 (3.2); 0.0079 (0.8); -0.0002 (28.0); -0.0085 (0.9) 1.71-140: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3313 (1.8); 7.3293 (1.7); 7.3185 (1.2); 7.2598 (65.5); 6.9839 (1.0); 6.9651 (1.1); 6.9629 (1.2); 6.9443 (0.9); 4.4993 (0.6); 4.4799 (1.3); 4.4604 (0.7); 2.3257 (0.7); 1.9822 (5.0); 1.9807 (4.6); 1.8264 (16.0); 1.8076 (1.2); 1.5454δ = 7.3313 (1.8); 7.3293 (1.7); 7.3185 (1.2); 7.2598 (65.5); 6.9839 (1.0); 6.9651 (1.1); 6.9629 (1.2); 6.9443 (0.9); 4.4993 (0.6); 4.4799 (1.3); 4.4604 (0.7); 2.3257 (0.7); 1.9822 (5.0); 1.9807 (4.6); 1.8264 (16.0); 1.8076 (1.2); 1.5454

(1.4); 1.2554 (0.6); 0.0080 (0.6); -0.0002 (23.7); -0.0085 (0.8) (1.4); 1.2554 (0.6); 0.0080 (0.6); -0.0002 (23.7); -0.0085 (0.8)

1.71-141 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-141: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3620 (0.6); 7.3382 (0.5); 7.3171 (0.9); 7.3006 (0.5); 7.2985 (0.6); 7.2963 (0.9); 7.2597 (82.4); 6.9958 (0.5); 6.9821 (1.0); 6.9634 (1.2); 6.9612 (1.1); 6.9425 (0.9); 3.8319 (2.5); 2.0456 (0.7); 2.0438 (0.8); 2.0403 (0.8); 2.0386 (0.7); 1.9908 (4.8); 1.9891 (4.8); 1.8654 (1.0); 1.8410 (16.0); 1.8204 (3.8); 1.5504 (2.9); 0.0080 (0.8); -0.0002 (29.2);δ = 7.3620 (0.6); 7.3382 (0.5); 7.3171 (0.9); 7.3006 (0.5); 7.2985 (0.6); 7.2963 (0.9); 7.2597 (82.4); 6.9958 (0.5); 6.9821 (1.0); 6.9634 (1.2); 6.9612 (1.1); 6.9425 (0.9); 3.8319 (2.5); 2.0456 (0.7); 2.0438 (0.8); 2.0403 (0.8); 2.0386 (0.7); 1.9908 (4.8); 1.9891 (4.8); 1.8654 (1.0); 1.8410 (16.0); 1.8204 (3.8); 1.5504 (2.9); 0.0080 (0.8); -0.0002 (29.2);

-0.0085 (0.9) -0.0085 (0.9)

1.71-142: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-142: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7657 (1.0); 7.8895 (2.6); 7.8877 (2.5); 7.5603 (0.5); 7.5392 (1.0); 7.5181 (0.6); 7.2318 (1.5); 7.2118 (2.1); 7.1917 (1.3); 3.3748 (0.6); 3.3386 (2.3); 2.9219 (0.8); 2.5511 (0.6); 2.5236 (1.0); 2.5189 (1.4); 2.5103 (13.0); 2.5058δ = 8.7657 (1.0); 7.8895 (2.6); 7.8877 (2.5); 7.5603 (0.5); 7.5392 (1.0); 7.5181 (0.6); 7.2318 (1.5); 7.2118 (2.1); 7.1917 (1.3); 3.3748 (0.6); 3.3386 (2.3); 2.9219 (0.8); 2.5511 (0.6); 2.5236 (1.0); 2.5189 (1.4); 2.5103 (13.0); 2.5058

(26.2); 2.5012 (35.2); 2.4967 (24.3); 2.4921 (11.1); 2.4561 (1.1); 1.9325 (6.8); 1.7077 (16.0); -0.0002 (3.6) (26.2); 2.5012 (35.2); 2.4967 (24.3); 2.4921 (11.1); 2.4561 (1.1); 1.9325 (6.8); 1.7077 (16.0); -0.0002 (3.6)

1.71-143: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-143: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.9768 (1.2); 7.8851 (2.9); 7.5398 (0.6); 7.5234 (1.0); 7.5024 (0.7); 7.2197 (1.5); 7.2001 (2.4); 7.1805 (1.4);δ = 7.9768 (1.2); 7.8851 (2.9); 7.5398 (0.6); 7.5234 (1.0); 7.5024 (0.7); 7.2197 (1.5); 7.2001 (2.4); 7.1805 (1.4);

5.7530 (0.8); 3.3126 (32.9); 2.5008 (55.0); 2.4967 (41.9); 1.9302 (7.9); 1.7019 (16.0); -0.0002 (12.5) 5.7530 (0.8); 3.3126 (32.9); 2.5008 (55.0); 2.4967 (41.9); 1.9302 (7.9); 1.7019 (16.0); -0.0002 (12.5)

1.71-144: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-144: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8764 (6.0); 7.5419 (0.9); 7.5227 (1.6); 7.5021 (1.1); 7.2223 (2.6); 7.2029 (4.2); 7.1832 (2.4); 5.7533 (1.8); 5.7510 (1.4); 4.5840 (0.5); 3.3134 (65.1); 3.0983 (0.6); 3.0432 (0.6); 3.0320 (0.7); 3.0180 (0.8); 3.0069 (1.1); 2.9724 (0.5); 2.8160 (1.1); 2.5010 (60.4); 1.9266 (14.6); 1.7037 (16.0); 1.2349 (2.7); 1.1749 (0.6); -0.0002 (16.8); -0.0022δ = 7.8764 (6.0); 7.5419 (0.9); 7.5227 (1.6); 7.5021 (1.1); 7.2223 (2.6); 7.2029 (4.2); 7.1832 (2.4); 5.7533 (1.8); 5.7510 (1.4); 4.5840 (0.5); 3.3134 (65.1); 3.0983 (0.6); 3.0432 (0.6); 3.0320 (0.7); 3.0180 (0.8); 3.0069 (1.1); 2.9724 (0.5); 2.8160 (1.1); 2.5010 (60.4); 1.9266 (14.6); 1.7037 (16.0); 1.2349 (2.7); 1.1749 (0.6); -0.0002 (16.8); -0.0022

(15-2) (15-2)

1.71-145: 1 H-NMR(400.0 MHz, CDCI3):  1.71-145: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3464 (1.8); 7.3444 (1.8); 7.3400 (0.6); 7.3189 (0.8); 7.2979 (0.5); 7.2611 (22.5); 6.9814 (1.0); 6.9627 (1.1);δ = 7.3464 (1.8); 7.3444 (1.8); 7.3400 (0.6); 7.3189 (0.8); 7.2979 (0.5); 7.2611 (22.5); 6.9814 (1.0); 6.9627 (1.1);

6.9605 (1.0); 6.9418 (0.9); 2.2104 (5.7); 1.9930 (4.6); 1.9913 (4.7); 1.8352 (16.0); -0.0002 (7.9) 6.9605 (1.0); 6.9418 (0.9); 2.2104 (5.7); 1.9930 (4.6); 1.9913 (4.7); 1.8352 (16.0); -0.0002 (7.9)

1.71-146: 1 H-NMR(400.0 MHz, CDCI3):  1.71-146: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3636 (2.1); 7.3617 (2.1); 7.3226 (0.8); 7.2611 (17.0); 6.9824 (1.0); 6.9636 (1.3); 6.9619 (1.2); 6.9432 (0.9);δ = 7.3636 (2.1); 7.3617 (2.1); 7.3226 (0.8); 7.2611 (17.0); 6.9824 (1.0); 6.9636 (1.3); 6.9619 (1.2); 6.9432 (0.9);

5.2984 (1.7); 1.9950 (5.5); 1.8394 (16.0); 1.5612 (4.8); 1.4366 (26.0); -0.0002 (7.6) 5.2984 (1.7); 1.9950 (5.5); 1.8394 (16.0); 1.5612 (4.8); 1.4366 (26.0); -0.0002 (7.6)

1.71-147: 1 H-NMR(400.0 MHz, CDCI3):  1.71-147: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3383 (2.1); 7.3177 (0.9); 7.2967 (0.5); 7.2606 (28.1); 6.9802 (1.1); 6.9617 (1.3); 6.9595 (1.2); 6.9410 (1.0); 3.4621 (0.8); 3.4484 (1.5); 3.4346 (0.9); 3.3237 (12.2); 2.5050 (0.8); 2.4912 (1.4); 2.4775 (0.8); 1.9860 (5.5); 1.8301δ = 7.3383 (2.1); 7.3177 (0.9); 7.2967 (0.5); 7.2606 (28.1); 6.9802 (1.1); 6.9617 (1.3); 6.9595 (1.2); 6.9410 (1.0); 3.4621 (0.8); 3.4484 (1.5); 3.4346 (0.9); 3.3237 (12.2); 2.5050 (0.8); 2.4912 (1.4); 2.4775 (0.8); 1.9860 (5.5); 1.8301

(16.0); 1.5644 (1.4); -0.0002 (10.7); -0.0084 (0.5) (16.0); 1.5644 (1.4); -0.0002 (10.7); -0.0084 (0.5)

1.71-148: 1 H-NMR(400.0 MHz, CDCI3):  1.71-148: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3495 (2.0); 7.3478 (1.8); 7.3328 (0.5); 7.3280 (1.0); 7.3070 (0.6); 7.2602 (39.8); 6.9882 (1.0); 6.9694 (1.2); 6.9673 (1.1); 6.9486 (1.0); 2.6214 (0.6); 2.6038 (1.5); 2.5869 (1.0); 2.4663 (1.0); 2.4495 (1.6); 2.4319 (0.6); 1.9940δ = 7.3495 (2.0); 7.3478 (1.8); 7.3328 (0.5); 7.3280 (1.0); 7.3070 (0.6); 7.2602 (39.8); 6.9882 (1.0); 6.9694 (1.2); 6.9673 (1.1); 6.9486 (1.0); 2.6214 (0.6); 2.6038 (1.5); 2.5869 (1.0); 2.4663 (1.0); 2.4495 (1.6); 2.4319 (0.6); 1.9940

(4.9); 1.9925 (4.8); 1.8317 (16.0); 1.7915 (1.8); 1.5488 (4.1); -0.0002 (14.8) (4.9); 1.9925 (4.8); 1.8317 (16.0); 1.7915 (1.8); 1.5488 (4.1); -0.0002 (14.8)

1.71-149: 1 H-NMR(400.0 MHz, CDCI3):  1.71-149: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4591 (1.6); 7.4572 (1.6); 7.2940 (0.8); 7.2730 (0.5); 7.2595 (28.3); 6.9571 (1.0); 6.9382 (1.1); 6.9363 (1.0); 6.9174 (0.8); 5.7446 (0.6); 5.7119 (0.7); 4.1967 (0.9); 4.1915 (1.2); 4.1848 (1.0); 3.6000 (0.9); 3.5944 (1.1); 3.5889δ = 7.4591 (1.6); 7.4572 (1.6); 7.2940 (0.8); 7.2730 (0.5); 7.2595 (28.3); 6.9571 (1.0); 6.9382 (1.1); 6.9363 (1.0); 6.9174 (0.8); 5.7446 (0.6); 5.7119 (0.7); 4.1967 (0.9); 4.1915 (1.2); 4.1848 (1.0); 3.6000 (0.9); 3.5944 (1.1); 3.5889

(0.9); 2.0029 (4.6); 2.0014 (4.6); 1.8615 (16.0); 1.5460 (1.6); -0.0002 (10.2) (0.9); 2.0029 (4.6); 2.0014 (4.6); 1.8615 (16.0); 1.5460 (1.6); -0.0002 (10.2)

1.71-150: 1 H-NMR(400.0 MHz, CDCI3):  1.71-150: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4336 (1.7); 7.4316 (1.7); 7.2935 (0.8); 7.2726 (0.6); 7.2596 (32.5); 6.9584 (1.0); 6.9566 (0.7); 6.9412 (0.7); 6.9394 (1.1); 6.9375 (1.0); 6.9186 (0.8); 3.7493 (0.8); 3.7352 (0.6); 3.1896 (0.6); 3.1761 (0.8); 3.1640 (0.6); 2.0009δ = 7.4336 (1.7); 7.4316 (1.7); 7.2935 (0.8); 7.2726 (0.6); 7.2596 (32.5); 6.9584 (1.0); 6.9566 (0.7); 6.9412 (0.7); 6.9394 (1.1); 6.9375 (1.0); 6.9186 (0.8); 3.7493 (0.8); 3.7352 (0.6); 3.1896 (0.6); 3.1761 (0.8); 3.1640 (0.6); 2.0009

(4.4) ; 1.9991 (4.6); 1.8298 (16.0); 1.6601 (0.6); 1.6458 (0.5); 1.6113 (0.6); 1.5981 (0.6); 1.5536 (0.5); -0.0002 (12.8) 1.71-151 : 1 H-NMR(400.0 MHz, CDCI3): (4.4); 1.9991 (4.6); 1.8298 (16.0); 1.6601 (0.6); 1.6458 (0.5); 1.6113 (0.6); 1.5981 (0.6); 1.5536 (0.5); -0.0002 (12.8) 1.71-151: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5188 (1.0); 7.4292 (4.8); 7.4273 (4.7); 7.3416 (0.7); 7.3257 (1.3); 7.3210 (1.0); 7.3098 (1.1); 7.3047 (2.2); 7.2995 (0.9); 7.2888 (1.2); 7.2837 (1.7); 7.2599 (179.1); 7.2230 (0.7); 6.9959 (1.1); 6.9665 (2.8); 6.9475 (3.2); 6.9458 (2.9); 6.9268 (2.4); 4.5323 (0.8); 4.4984 (0.9); 4.2255 (1.5); 4.2163 (0.7); 4.2077 (1.5); 4.1986 (2.1); 4.1899 (0.6); 4.1807 (2.1); 4.1630 (0.7); 4.1117 (0.7); 4.0938 (2.0); 4.0759 (2.1); 4.0668 (1.5); 4.0581 (0.8); 4.0490 (1.5); 3.1768 (1.1); 3.1706 (1.2); 3.1472 (1.3); 3.1410 (1.2); 3.0257 (0.6); 2.9930 (0.7); 2.9865 (0.8); 2.9731 (0.7); 2.9541 (0.7); 2.1698 (6.1); 2.0268 (1.0); 1.9928 (14.6); 1.9422 (1.0); 1.9184 (13.4); 1.9169 (13.5); 1.8902 (3.0); 1.8665 (0.7); 1.7691 (1.1); 1.7568 (1.7); 1.7396 (16.0); 1.7206 (1.1); 1.6589 (0.9); 1.6295 (1.1); 1.5973 (1.2); 1.5751 (1.6); 1.5541δ = 7.5188 (1.0); 7.4292 (4.8); 7.4273 (4.7); 7.3416 (0.7); 7.3257 (1.3); 7.3210 (1.0); 7.3098 (1.1); 7.3047 (2.2); 7.2995 (0.9); 7.2888 (1.2); 7.2837 (1.7); 7.2599 (179.1); 7.2230 (0.7); 6.9959 (1.1); 6.9665 (2.8); 6.9475 (3.2); 6.9458 (2.9); 6.9268 (2.4); 4.5323 (0.8); 4.4984 (0.9); 4.2255 (1.5); 4.2163 (0.7); 4.2077 (1.5); 4.1986 (2.1); 4.1899 (0.6); 4.1807 (2.1); 4.1630 (0.7); 4.1117 (0.7); 4.0938 (2.0); 4.0759 (2.1); 4.0668 (1.5); 4.0581 (0.8); 4.0490 (1.5); 3.1768 (1.1); 3.1706 (1.2); 3.1472 (1.3); 3.1410 (1.2); 3.0257 (0.6); 2.9930 (0.7); 2.9865 (0.8); 2.9731 (0.7); 2.9541 (0.7); 2.1698 (6.1); 2.0268 (1.0); 1.9928 (14.6); 1.9422 (1.0); 1.9184 (13.4); 1.9169 (13.5); 1.8902 (3.0); 1.8665 (0.7); 1.7691 (1.1); 1.7568 (1.7); 1.7396 (16.0); 1.7206 (1.1); 1.6589 (0.9); 1.6295 (1.1); 1.5973 (1.2); 1.5751 (1.6); 1.5541

(1.5) ; 1.2843 (0.6); 1.2592 (8.4); 1.2413 (15.5); 1.2235 (7.3); 0.0079 (2.0); -0.0002 (65.6); -0.0085 (2.8) (1.5); 1.2843 (0.6); 1.2592 (8.4); 1.2413 (15.5); 1.2235 (7.3); 0.0079 (2.0); -0.0002 (65.6); -0.0085 (2.8)

1.71-152: 1 H-NMR(400.0 MHz, CDCI3):  1.71-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3746 (1.6); 7.3727 (1.6); 7.3253 (0.8); 7.2606 (16.8); 6.9849 (1.0); 6.9662 (1.1); 6.9640 (1.0); 6.9454 (0.9);δ = 7.3746 (1.6); 7.3727 (1.6); 7.3253 (0.8); 7.2606 (16.8); 6.9849 (1.0); 6.9662 (1.1); 6.9640 (1.0); 6.9454 (0.9);

1.9966 (4.5); 1.9953 (4.6); 1.8399 (16.0); 1.5580 (1.8); -0.0002 (6.6) 1.9966 (4.5); 1.9953 (4.6); 1.8399 (16.0); 1.5580 (1.8); -0.0002 (6.6)

1.71-153: 1 H-NMR(400.0 MHz, CDCI3):  1.71-153: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4522 (3.6); 7.3653 (0.6); 7.3492 (1.0); 7.3442 (1.0); 7.3283 (1.9); 7.3233 (0.7); 7.3120 (1.0); 7.3073 (1.2); 7.2913 (0.7); 7.2600 (88.6); 6.9962 (0.8); 6.9868 (2.6); 6.9682 (3.2); 6.9481 (2.2); 5.2984 (1.4); 5.0759 (1.6); 5.0674δ = 7.4522 (3.6); 7.3653 (0.6); 7.3492 (1.0); 7.3442 (1.0); 7.3283 (1.9); 7.3233 (0.7); 7.3120 (1.0); 7.3073 (1.2); 7.2913 (0.7); 7.2600 (88.6); 6.9962 (0.8); 6.9868 (2.6); 6.9682 (3.2); 6.9481 (2.2); 5.2984 (1.4); 5.0759 (1.6); 5.0674

(1.6) ; 4.4367 (1.5); 4.4070 (1.6); 4.2845 (0.5); 4.2751 (0.5); 4.2661 (0.6); 4.2571 (1.6); 4.2392 (1.8); 4.2349 (1.8); 4.2170 (1.7); 4.2077 (0.6); 4.1990 (0.6); 4.1901 (0.6); 3.6492 (1.3); 3.6396 (1.2); 3.6195 (1.2); 3.6097 (1.1); 3.5445 (0.8); 3.5234 (1.2); 3.1736 (1.7); 3.1664 (1.4); 3.1611 (1.5); 3.1506 (1.4); 3.1415 (1.3); 3.1372 (1.2); 2.9860 (1.2); 2.9577 (0.7); 2.0046 (11.6); 1.9860 (1.1); 1.8759 (12.4); 1.8521 (12.4); 1.8250 (1.1); 1.8040 (0.7); 1.5432 (16.0); 1.3175 (4.0); 1.2997 (8.1); 1.2818 (4.0); 1.2561 (0.6); 0.0077 (1.1); -0.0002 (32.3); -0.0084 (0.9) 1.71-154: 1 H-NMR(400.0 MHz, CDCI3): (1.6); 4.4367 (1.5); 4.4070 (1.6); 4.2845 (0.5); 4.2751 (0.5); 4.2661 (0.6); 4.2571 (1.6); 4.2392 (1.8); 4.2349 (1.8); 4.2170 (1.7); 4.2077 (0.6); 4.1990 (0.6); 4.1901 (0.6); 3.6492 (1.3); 3.6396 (1.2); 3.6195 (1.2); 3.6097 (1.1); 3.5445 (0.8); 3.5234 (1.2); 3.1736 (1.7); 3.1664 (1.4); 3.1611 (1.5); 3.1506 (1.4); 3.1415 (1.3); 3.1372 (1.2); 2.9860 (1.2); 2.9577 (0.7); 2.0046 (11.6); 1.9860 (1.1); 1.8759 (12.4); 1.8521 (12.4); 1.8250 (1.1); 1.8040 (0.7); 1.5432 (16.0); 1.3175 (4.0); 1.2997 (8.1); 1.2818 (4.0); 1.2561 (0.6); 0.0077 (1.1); -0.0002 (32.3); -0.0084 (0.9) 1.71-154: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3950 (2.9); 7.3841 (0.6); 7.3680 (0.9); 7.3630 (0.8); 7.3520 (0.6); 7.3470 (1.8); 7.3419 (0.6); 7.3310 (0.8); 7.3259 (1.1); 7.3100 (0.6); 7.2597 (69.0); 7.0002 (2.4); 6.9814 (2.7); 6.9794 (2.5); 6.9606 (2.1); 5.2983 (5.5); 3.2300 (1.2); 3.2071 (1.1); 2.0046 (11.3); 2.0032 (11.1); 1.8640 (7.9); 1.8582 (16.0); 1.5393 (9.1); 0.0080 (0.7); -0.0002δ = 7.3950 (2.9); 7.3841 (0.6); 7.3680 (0.9); 7.3630 (0.8); 7.3520 (0.6); 7.3470 (1.8); 7.3419 (0.6); 7.3310 (0.8); 7.3259 (1.1); 7,331 (0.6); 7.2597 (69.0); 7,0002 (2.4); 6.9814 (2.7); 6.9794 (2.5); 6.9606 (2.1); 5.2983 (5.5); 3.2300 (1.2); 3.2071 (1.1); 2.0046 (11.3); 2.0032 (11.1); 1.8640 (7.9); 1.8582 (16.0); 1.5393 (9.1); 0.0080 (0.7); -0.0002

(24.0); -0.0085 (0.8) (24.0); -0.0085 (0.8)

1.71-155: 1 H-NMR(400.0 MHz, CDCI3):  1.71-155: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5184 (0.6); 7.3734 (0.7); 7.3638 (2.4); 7.3576 (1.4); 7.3526 (0.9); 7.3416 (0.6); 7.3365 (1.8); 7.3314 (0.7); 7.3206 (1.0); 7.3154 (1.2); 7.2995 (0.6); 7.2595 (100.1); 6.9955 (0.7); 6.9914 (2.4); 6.9726 (2.6); 6.9705 (2.4); 6.9622 (0.5); 6.9518 (2.0); 3.6199 (0.7); 3.1801 (1.0); 3.1546 (1.0); 1.9996 (11.2); 1.9980 (11.2); 1.9863 (0.8); 1.9844 (0.7);δ = 7.5184 (0.6); 7.3734 (0.7); 7.3638 (2.4); 7.3576 (1.4); 7.3526 (0.9); 7.3416 (0.6); 7.3365 (1.8); 7.3314 (0.7); 7.3206 (1.0); 7.3154 (1.2); 7.2995 (0.6); 7.2595 (100.1); 6.9955 (0.7); 6.9914 (2.4); 6.9726 (2.6); 6.9705 (2.4); 6.9622 (0.5); 6.9518 (2.0); 3.6199 (0.7); 3.1801 (1.0); 3.1546 (1.0); 1.9996 (11.2); 1.9980 (11.2); 1.9863 (0.8); 1.9844 (0.7);

1.8627 (16.0); 1.8573 (8.1); 1.8250 (2.4); 1.5363 (12.1); 0.0080 (1.1); -0.0002 (37.2); -0.0085 (1.1) 1.8627 (16.0); 1.8573 (8.1); 1.8250 (2.4); 1.5363 (12.1); 0.0080 (1.1); -0.0002 (37.2); -0.0085 (1.1)

1.71-156: 1 H-NMR(400.0 MHz, CDCI3):  1.71-156: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3587 (4.4); 7.3568 (4.4); 7.3464 (1.2); 7.3412 (0.9); 7.3305 (0.6); 7.3253 (2.0); 7.3202 (0.7); 7.3099 (1.2); 7.3043 (1.2); 7.2884 (0.6); 7.2599 (86.6); 6.9959 (0.6); 6.9873 (2.5); 6.9685 (2.9); 6.9664 (2.7); 6.9478 (2.2); 2.7958 (0.5); 2.4850 (0.8); 2.4589 (0.9); 2.4517 (0.9); 2.4255 (0.7); 1.9962 (11.9); 1.9948 (12.0); 1.8374 (16.0); 1.8320δ = 7.3587 (4.4); 7.3568 (4.4); 7.3464 (1.2); 7.3412 (0.9); 7.3305 (0.6); 7.3253 (2.0); 7.3202 (0.7); 7.3099 (1.2); 7.3043 (1.2); 7.2884 (0.6); 7.2599 (86.6); 6.9959 (0.6); 6.9873 (2.5); 6.9685 (2.9); 6.9664 (2.7); 6.9478 (2.2); 2.7958 (0.5); 2.4850 (0.8); 2.4589 (0.9); 2.4517 (0.9); 2.4255 (0.7); 1.9962 (11.9); 1.9948 (12.0); 1.8374 (16.0); 1.8320

(15.6); 1.5452 (5.5); 0.0080 (0.9); -0.0002 (32.1); -0.0085 (1.1) (15.6); 1.5452 (5.5); 0.0080 (0.9); -0.0002 (32.1); -0.0085 (1.1)

1.71-157: 1 H-NMR(400.0 MHz, CDCI3):  1.71-157: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3966 (3.9); 7.3710 (0.6); 7.3550 (1.2); 7.3500 (1.0); 7.3391 (0.7); 7.3340 (2.2); 7.3289 (0.8); 7.3181 (1.0); 7.3129 (1.4); 7.2970 (0.7); 7.2606 (32.4); 6.9919 (3.0); 6.9854 (0.6); 6.9815 (0.6); 6.9730 (3.6); 6.9711 (3.3); 6.9628 (0.7); 6.9523 (2.6); 3.4876 (0.6); 2.9504 (0.5); 2.9226 (1.7); 2.8958 (1.4); 2.8892 (1.4); 2.8628 (0.9); 1.9988 (14.4);δ = 7.3966 (3.9); 7.3710 (0.6); 7.3550 (1.2); 7.3500 (1.0); 7.3391 (0.7); 7.3340 (2.2); 7.3289 (0.8); 7.3181 (1.0); 7.3129 (1.4); 7.2970 (0.7); 7.2606 (32.4); 6.9919 (3.0); 6.9854 (0.6); 6.9815 (0.6); 6.9730 (3.6); 6.9711 (3.3); 6.9628 (0.7); 6.9523 (2.6); 3.4876 (0.6); 2.9504 (0.5); 2.9226 (1.7); 2.8958 (1.4); 2.8892 (1.4); 2.8628 (0.9); 1.9988 (14.4);

1.9973 (14.1); 1.8451 (16.0); 1.8333 (11.1); 1.5589 (2.6); -0.0002 (12.5) 1.9973 (14.1); 1.8451 (16.0); 1.8333 (11.1); 1.5589 (2.6); -0.0002 (12.5)

1.71-158: 1 H-NMR(400.0 MHz, CDCI3):  1.71-158: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3628 (1.6); 7.3413 (4.6); 7.3300 (0.9); 7.3251 (2.1); 7.3201 (0.8); 7.3095 (1.2); 7.3042 (1.3); 7.2883 (0.8); 7.2605 (64.5); 7.2600 (65.2); 6.9960 (0.6); 6.9888 (2.9); 6.9701 (3.5); 6.9600 (0.7); 6.9497 (2.5); 5.2984 (0.5); 2.3551 (0.8); 1.9952 (11.8); 1.8548 (5.0); 1.8300 (16.0); 1.5462 (10.8); 1.1279 (0.8); 0.9642 (0.8); 0.0077 (0.8); -0.0002δ = 7.3628 (1.6); 7.3413 (4.6); 7.3300 (0.9); 7.3251 (2.1); 7.3201 (0.8); 7.3095 (1.2); 7.3042 (1.3); 7.2883 (0.8); 7.2605 (64.5); 7.2600 (65.2); 6.9960 (0.6); 6.9888 (2.9); 6.9701 (3.5); 6.9600 (0.7); 6.9497 (2.5); 5.2984 (0.5); 2.3551 (0.8); 1.9952 (11.8); 1.8548 (5.0); 1.8300 (16.0); 1.5462 (10.8); 1.1279 (0.8); 0.9642 (0.8); 0.0077 (0.8); -0.0002

(23.4); -0.0080 (1.2) (23.4); -0.0080 (1.2)

1.71-159: 1 H-NMR(400.0 MHz, CDCI3):  1.71-159: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3948 (4.6); 7.3929 (4.5); 7.3577 (0.5); 7.3419 (1.2); 7.3369 (1.0); 7.3259 (0.7); 7.3209 (2.1); 7.3157 (0.7); 7.3052 (0.9); 7.2998 (1.2); 7.2840 (0.6); 7.2606 (47.3); 6.9973 (0.5); 6.9871 (2.8); 6.9682 (3.2); 6.9663 (2.9); 6.9579 (0.5); 6.9476 (2.4); 5.2982 (1.8); 3.8062 (2.1); 3.7781 (3.7); 3.7127 (2.1); 3.7074 (2.2); 3.6846 (1.2); 3.6793 (1.3); 3.2006 (0.5); 3.1943 (0.6); 3.1847 (0.7); 3.1789 (0.7); 3.1741 (0.7); 3.1680 (0.7); 3.1585 (0.7); 3.1523 (0.6); 2.9298 (1.4); 2.9236 (1.4); 2.8944 (1.7); 2.8883 (1.6); 2.6538 (0.9); 2.6475 (0.6); 2.6290 (0.6); 2.6217 (1.0); 2.5972 (0.6); 2.5192 (1.6); 2.4927 (1.5); 2.4838 (1.4); 2.4573 (1.3); 2.3333 (0.6); 2.3265 (0.6); 2.3198 (0.7); 2.3134 (0.6); 2.1635 (0.7); 2.1505 (0.6); 2.1453 (0.7); 2.1310 (0.6); 2.0045 (12.4); 2.0031 (12.0); 1.8686 (0.8); 1.8639 (0.8); 1.8432 (1.2); 1.8381 (1.4); 1.8277 (16.0); 1.7990 (15.2); 1.7832 (1.0); 1.7787 (1.0); 1.7738 (0.5); 1.7601 (0.7); 1.7551 (1.0); 1.7501 (0.6); 1.6826 (0.5); 1.6769 (0.6); 1.6567 (1.0); 1.6362 (0.6); 1.6312 (0.8); 1.5510 (6.3); 0.8990 (9.0); 0.8834 (8.9);δ = 7.3948 (4.6); 7.3929 (4.5); 7.3577 (0.5); 7.3419 (1.2); 7.3369 (1.0); 7.3259 (0.7); 7.3209 (2.1); 7.3157 (0.7); 7.3052 (0.9); 7.2998 (1.2); 7.2840 (0.6); 7.2606 (47.3); 6.9973 (0.5); 6.9871 (2.8); 6.9682 (3.2); 6.9663 (2.9); 6.9579 (0.5); 6.9476 (2.4); 5.2982 (1.8); 3.8062 (2.1); 3.7781 (3.7); 3.7127 (2.1); 3.7074 (2.2); 3.6846 (1.2); 3.6793 (1.3); 3.2006 (0.5); 3.1943 (0.6); 3.1847 (0.7); 3.1789 (0.7); 3.1741 (0.7); 3.1680 (0.7); 3.1585 (0.7); 3.1523 (0.6); 2.9298 (1.4); 2.9236 (1.4); 2.8944 (1.7); 2.8883 (1.6); 2.6538 (0.9); 2.6475 (0.6); 2.6290 (0.6); 2.6217 (1.0); 2.5972 (0.6); 2.5192 (1.6); 2.4927 (1.5); 2.4838 (1.4); 2.4573 (1.3); 2.3333 (0.6); 2.3265 (0.6); 2.3198 (0.7); 2.3134 (0.6); 2.1635 (0.7); 2.1505 (0.6); 2.1453 (0.7); 2.1310 (0.6); 2.0045 (12.4); 2.0031 (12.0); 1.8686 (0.8); 1.8639 (0.8); 1.8432 (1.2); 1.8381 (1.4); 1.8277 (16.0); 1.7990 (15.2); 1.7832 (1.0); 1.7787 (1.0); 1.7738 (0.5); 1.7601 (0.7); 1.7551 (1.0); 1.7501 (0.6); 1.6826 (0.5); 1.6769 (0.6); 1.6567 (1.0); 1.6362 (0.6); 1.6312 (0.8); 1.5510 (6.3); 0.8990 (9.0); 0.8834 (8.9);

0.0080 (0.6); -0.0002 (22.0); -0.0085 (0.7) 0.0080 (0.6); -0.0002 (22.0); -0.0085 (0.7)

1.71-160: 1 H-NMR(400.0 MHz, CDCI3):  1.71-160: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3630 (2.0); 7.3256 (0.8); 7.2603 (14.3); 6.9872 (1.0); 6.9683 (1.2); 6.9482 (0.9); 5.2983 (5.1); 2.0007 (5.5);δ = 7.3630 (2.0); 7.3256 (0.8); 7.2603 (14.3); 6.9872 (1.0); 6.9683 (1.2); 6.9482 (0.9); 5.2983 (5.1); 2,0007 (5.5);

1.8369 (16.0); -0.0002 (5.7) 1.8369 (16.0); -0.0002 (5.7)

1.71-161 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-161: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4250 (1.7); 7.4230 (1.6); 7.3526 (0.8); 7.2667 (0.6); 7.2597 (60.6); 7.0094 (1.0); 6.9903 (1.2); 6.9886 (1.1); 6.9696 (0.9); 3.2004 (0.7); 2.9994 (0.8); 2.0095 (4.6); 2.0080 (4.5); 1.8652 (16.0); 0.0080 (0.7); -0.0002 (22.7); -δ = 7.4250 (1.7); 7.4230 (1.6); 7.3526 (0.8); 7.2667 (0.6); 7.2597 (60.6); 7.0094 (1.0); 6.9903 (1.2); 6.9886 (1.1); 6.9696 (0.9); 3.2004 (0.7); 2.9994 (0.8); 2.0095 (4.6); 2.0080 (4.5); 1.8652 (16.0); 0.0080 (0.7); -0.0002 (22.7); -

0.0085 (0.6) 0.0085 (0.6)

1.71-162: 1 H-NMR(400.0 MHz, CDCI3):  1.71-162: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3425 (1.7); 7.3405 (1.7); 7.3099 (0.8); 7.2604 (21.5); 6.9771 (1.0); 6.9584 (1.1); 6.9563 (1.0); 6.9376 (0.8);δ = 7.3425 (1.7); 7.3405 (1.7); 7.3099 (0.8); 7.2604 (21.5); 6.9771 (1.0); 6.9584 (1.1); 6.9563 (1.0); 6.9376 (0.8);

1.9852 (4.6); 1.9836 (4.5); 1.8472 (16.0); 1.5566 (3.1); 1.4139 (0.8); -0.0002 (8.1) 1.9852 (4.6); 1.9836 (4.5); 1.8472 (16.0); 1.5566 (3.1); 1.4139 (0.8); -0.0002 (8.1)

1.71-163: 1 H-NMR(400.0 MHz, CDCI3):  1.71-163: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.8450 (0.6); 7.5345 (1.9); 7.5329 (1.9); 7.3923 (0.9); 7.3711 (0.5); 7.2600 (43.0); 7.0098 (1.3); 6.9907 (1.6);δ = 7.8450 (0.6); 7.5345 (1.9); 7.5329 (1.9); 7.3923 (0.9); 7.3711 (0.5); 7.2600 (43.0); 7.0098 (1.3); 6.9907 (1.6);

6.9699 (1.1); 3.2557 (0.7); 2.0089 (5.9); 1.8596 (16.0); 0.0079 (0.6); -0.0002 (21.4); -0.0085 (0.7) 6.9699 (1.1); 3.2557 (0.7); 2.0089 (5.9); 1.8596 (16.0); 0.0079 (0.6); -0.0002 (21.4); -0.0085 (0.7)

1.71-164: 1 H-NMR(400.0 MHz, CDCI3):  1.71-164: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3896 (0.8); 7.3350 (0.6); 7.3148 (0.8); 7.2973 (0.6); 7.2604 (70.1); 6.9756 (1.0); 6.9573 (1.6); 6.9380 (0.9); 5.2983 (3.7); 3.5011 (0.6); 3.3515 (0.7); 3.2874 (0.9); 3.1281 (0.6); 1.9891 (7.6); 1.8367 (16.0); 1.5573 (5.6); 1.4370δ = 7.3896 (0.8); 7.3350 (0.6); 7.3148 (0.8); 7.2973 (0.6); 7.2604 (70.1); 6.9756 (1.0); 6.9573 (1.6); 6.9380 (0.9); 5.2983 (3.7); 3.5011 (0.6); 3.3515 (0.7); 3.2874 (0.9); 3.1281 (0.6); 1.9891 (7.6); 1.8367 (16.0); 1.5573 (5.6); 1.4370

(22.9); 0.0080 (0.8); -0.0002 (25.8); -0.0085 (0.8) (22.9); 0.0080 (0.8); -0.0002 (25.8); -0.0085 (0.8)

1.71-165: 1 H-NMR(400.0 MHz, CDCI3):  1.71-165: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5310 (1.5); 7.5291 (1.6); 7.3458 (0.8); 7.2598 (23.8); 7.0137 (0.9); 6.9945 (1.1); 6.9929 (1.0); 6.9737 (0.9);δ = 7.5310 (1.5); 7.5291 (1.6); 7.3458 (0.8); 7.2598 (23.8); 7.0137 (0.9); 6.9945 (1.1); 6.9929 (1.0); 6.9737 (0.9);

2.0285 (4.2); 2.0266 (4.2); 1.8894 (16.0); 1.8772 (0.6); 1.8713 (0.6); 1.8071 (0.6); -0.0002 (8.4) 2.0285 (4.2); 2.0266 (4.2); 1.8894 (16.0); 1.8772 (0.6); 1.8713 (0.6); 1.8071 (0.6); -0.0002 (8.4)

1.71-166: 1 H-NMR(400.0 MHz, CDCI3):  1.71-166: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5111 (1.6); 7.5091 (1.6); 7.3516 (0.8); 7.2598 (36.3); 7.2532 (0.6); 7.2524 (0.6); 7.0227 (0.9); 7.0034 (1.1); 7.0019 (1.0); 6.9826 (0.8); 2.7343 (5.3); 2.7223 (5.3); 2.0290 (4.2); 2.0270 (4.2); 1.8665 (16.0); 1.5451 (2.6); -0.0002δ = 7.5111 (1.6); 7.5091 (1.6); 7.3516 (0.8); 7.2598 (36.3); 7.2532 (0.6); 7.2524 (0.6); 7.0227 (0.9); 7.0034 (1.1); 7.0019 (1.0); 6.9826 (0.8); 2.7343 (5.3); 2.7223 (5.3); 2.0290 (4.2); 2.0270 (4.2); 1.8665 (16.0); 1.5451 (2.6); -0.0002

(13-3) (13-3)

1.71-167: 1 H-NMR(400.0 MHz, CDCI3):  1.71-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5181 (0.9); 7.3455 (1.4); 7.3435 (1.4); 7.3110 (0.7); 7.2741 (0.5); 7.2593 (157.4); 6.9952 (0.9); 6.9768 (0.8); 6.9580 (0.9); 6.9559 (0.8); 6.9372 (0.7); 1.9959 (3.9); 1.9942 (4.0); 1.8325 (15.7); 1.5304 (16.0); 0.0080 (1.8); -δ = 7.5181 (0.9); 7.3455 (1.4); 7.3435 (1.4); 7.3110 (0.7); 7.2741 (0.5); 7.2593 (157.4); 6.9952 (0.9); 6.9768 (0.8); 6.9580 (0.9); 6.9559 (0.8); 6.9372 (0.7); 1.9959 (3.9); 1.9942 (4.0); 1.8325 (15.7); 1.5304 (16.0); 0.0080 (1.8); -

0.0002 (60.1); -0.0085 (1.7) 0.0002 (60.1); -0.0085 (1.7)

1.71-168: 1 H-NMR(400.0 MHz, CDCI3):  1.71-168: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.4337 (0.5); 7.5024 (1.6); 7.5005 (1.6); 7.3633 (0.8); 7.2612 (9.7); 7.0329 (1.0); 7.0135 (1.2); 7.0122 (1.0); 6.9929 (0.8); 5.2981 (0.7); 3.6910 (9.8); 2.0318 (4.2); 2.0297 (4.1); 1.8825 (16.0); -0.0002 (3.5) 1.71-169: 1 H-NMR(400.0 MHz, CDCI3): δ = 9.4337 (0.5); 7.5024 (1.6); 7.5005 (1.6); 7.3633 (0.8); 7.2612 (9.7); 7.0329 (1.0); 7.0135 (1.2); 7.0122 (1.0); 6.9929 (0.8); 5.2981 (0.7); 3.6910 (9.8); 2.0318 (4.2); 2.0297 (4.1); 1.8825 (16.0); -0.0002 (3.5) 1.71-169: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4913 (1.9); 7.4893 (1.8); 7.2877 (0.9); 7.2665 (0.8); 7.2600 (28.0); 6.9594 (1.1); 6.9404 (1.2); 6.9386 (1.1); 6.9198 (0.9); 4.5584 (6.7); 4.1956 (0.8); 4.1777 (2.6); 4.1599 (2.6); 4.1421 (0.8); 3.7552 (12.8); 1.9787 (5.1); 1.9770δ = 7.4913 (1.9); 7.4893 (1.8); 7.2877 (0.9); 7.2665 (0.8); 7.2600 (28.0); 6.9594 (1.1); 6.9404 (1.2); 6.9386 (1.1); 6.9198 (0.9); 4.5584 (6.7); 4.1956 (0.8); 4.1777 (2.6); 4.1599 (2.6); 4.1421 (0.8); 3.7552 (12.8); 1.9787 (5.1); 1.9770

(4.9); 1.8158 (16.0); 1.5494 (5.8); 1.2608 (3.2); 1.2429 (6.5); 1.2251 (3.1); -0.0002 (9.9) (4.9); 1.8158 (16.0); 1.5494 (5.8); 1.2608 (3.2); 1.2429 (6.5); 1.2251 (3.1); -0.0002 (9.9)

1.71-170: 1 H-NMR(400.0 MHz, CDCI3):  1.71-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5373 (1.6); 7.5354 (1.7); 7.5180 (1.0); 7.3588 (0.6); 7.3428 (0.8); 7.3215 (0.5); 7.2592 (174.4); 7.0126 (1.0); 6.9951 (1.7); 6.9727 (0.8); 3.9499 (2.7); 3.9359 (2.6); 3.7035 (10.0); 2.0333 (4.3); 2.0313 (4.3); 1.8937 (16.0); 1.5299δ = 7.5373 (1.6); 7.5354 (1.7); 7.5180 (1.0); 7.3588 (0.6); 7.3428 (0.8); 7.3215 (0.5); 7.2592 (174.4); 7.0126 (1.0); 6.9951 (1.7); 6.9727 (0.8); 3.9499 (2.7); 3.9359 (2.6); 3.7035 (10.0); 2.0333 (4.3); 2.0313 (4.3); 1.8937 (16.0); 1.5299

(13.4); 0.0079 (1.9); -0.0002 (64.5); -0.0085 (1.9) (13.4); 0.0079 (1.9); -0.0002 (64.5); -0.0085 (1.9)

1.71-172: 1 H-NMR(400.0 MHz, CDCI3):  1.71-172: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5329 (2.4); 7.5310 (2.4); 7.3658 (0.6); 7.3447 (1.1); 7.3237 (0.7); 7.2601 (46.2); 7.0130 (1.6); 7.0025 (0.6); 6.9940 (2.0); 6.9838 (0.6); 6.9733 (1.4); 4.4439 (0.9); 4.4258 (1.4); 4.4076 (0.9); 3.6884 (16.0); 2.0339 (6.3); 2.0322δ = 7.5329 (2.4); 7.5310 (2.4); 7.3658 (0.6); 7.3447 (1.1); 7.3237 (0.7); 7.2601 (46.2); 7.0130 (1.6); 7.0025 (0.6); 6.9940 (2.0); 6.9838 (0.6); 6.9733 (1.4); 4.4439 (0.9); 4.4258 (1.4); 4.4076 (0.9); 3.6884 (16.0); 2.0339 (6.3); 2.0322

(6.5) ; 1.8832 (9.2); 1.8696 (9.1); 1.5568 (4.0); 1.3415 (5.0); 1.3233 (5.0); 1.2648 (0.8); 0.8818 (1.4); 0.8641 (0.6);(6.5); 1.8832 (9.2); 1.8696 (9.1); 1.5568 (4.0); 1.3415 (5.0); 1.3233 (5.0); 1.2648 (0.8); 0.8818 (1.4); 0.8641 (0.6);

0.0079 (0.6); -0.0002 (19.1); -0.0085 (0.5) 0.0079 (0.6); -0.0002 (19.1); -0.0085 (0.5)

1.71-172: 1 H-NMR(400.0 MHz, CDCI3):  1.71-172: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5320 (2.6); 7.5302 (2.6); 7.3648 (0.6); 7.3598 (0.5); 7.3437 (1.2); 7.3279 (0.5); 7.3227 (0.7); 7.2609 (12.0); 7.0122 (1.6); 7.0055 (0.5); 7.0016 (0.6); 6.9931 (2.2); 6.9916 (2.1); 6.9829 (0.7); 6.9785 (0.7); 6.9725 (1.6); 5.2977 (0.9); 4.4444 (0.9); 4.4262 (1.4); 4.4081 (0.9); 3.6877 (16.0); 2.0335 (7.1); 2.0317 (7.0); 1.8823 (9.7); 1.8689 (9.7);δ = 7.5320 (2.6); 7.5302 (2.6); 7.3648 (0.6); 7.3598 (0.5); 7.3437 (1.2); 7.3279 (0.5); 7.3227 (0.7); 7.2609 (12.0); 7.0122 (1.6); 7.0055 (0.5); 7.0016 (0.6); 6.9931 (2.2); 6.9916 (2.1); 6.9829 (0.7); 6.9785 (0.7); 6.9725 (1.6); 5.2977 (0.9); 4.4444 (0.9); 4.4262 (1.4); 4.4081 (0.9); 3.6877 (16.0); 2.0335 (7.1); 2.0317 (7.0); 1.8823 (9.7); 1.8689 (9.7);

1.5680 (1.9); 1.3408 (5.3); 1.3226 (5.2); -0.0002 (7.1) 1.5680 (1.9); 1.3408 (5.3); 1.3226 (5.2); -0.0002 (7.1)

1.71-173: 1 H-NMR(400.0 MHz, CDCI3):  1.71-173: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5250 (1.8); 7.5231 (1.8); 7.3501 (0.8); 7.2612 (11.6); 7.0353 (0.5); 7.0164 (1.1); 6.9972 (1.4); 6.9766 (0.9);δ = 7.5250 (1.8); 7.5231 (1.8); 7.3501 (0.8); 7.2612 (11.6); 7.0353 (0.5); 7.0164 (1.1); 6.9972 (1.4); 6.9766 (0.9);

3.6857 (12.0); 2.0345 (4.8); 2.0328 (4.8); 1.8452 (16.0); 1.5740 (1.2); 1.4245 (14.8); -0.0002 (4.2) 3.6857 (12.0); 2.0345 (4.8); 2.0328 (4.8); 1.8452 (16.0); 1.5740 (1.2); 1.4245 (14.8); -0.0002 (4.2)

1.71-174: 1 H-NMR(400.0 MHz, CDCI3):  1.71-174: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5225 (1.8); 7.5206 (1.8); 7.3497 (0.8); 7.2603 (20.6); 7.0163 (1.2); 6.9971 (1.8); 6.9765 (1.0); 4.1645 (0.9); 4.1467 (2.8); 4.1289 (2.8); 4.1110 (0.9); 2.0331 (4.8); 2.0314 (4.7); 1.8471 (16.0); 1.5566 (2.0); 1.4185 (14.7); 1.2376δ = 7.5225 (1.8); 7.5206 (1.8); 7.3497 (0.8); 7.2603 (20.6); 7.0163 (1.2); 6.9971 (1.8); 6.9765 (1.0); 4.1645 (0.9); 4.1467 (2.8); 4.1289 (2.8); 4.1110 (0.9); 2.0331 (4.8); 2.0314 (4.7); 1.8471 (16.0); 1.5566 (2.0); 1.4185 (14.7); 1.2376

(2.9); 1.2198 (6.0); 1.2020 (2.8); -0.0002 (8.6) (2.9); 1.2198 (6.0); 1.2020 (2.8); -0.0002 (8.6)

1.71-175: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-175: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8208 (2.7); 7.8188 (2.6); 7.6724 (0.7); 7.5292 (0.6); 7.5081 (1.1); 7.4870 (0.6); 7.2099 (1.5); 7.1897 (2.1); 7.1695 (1.2); 4.0383 (1.2); 4.0205 (1.2); 3.7312 (3.2); 3.7168 (3.1); 3.3081 (11.9); 2.5228 (1.6); 2.5181 (2.3); 2.5094 (22.2); 2.5049 (45.4); 2.5003 (62.0); 2.4957 (42.0); 2.4912 (18.6); 1.9876 (5.7); 1.9256 (6.2); 1.9243 (6.1); 1.9079δ = 7.8208 (2.7); 7.8188 (2.6); 7.6724 (0.7); 7.5292 (0.6); 7.5081 (1.1); 7.4870 (0.6); 7.2099 (1.5); 7.1897 (2.1); 7.1695 (1.2); 4.0383 (1.2); 4.0205 (1.2); 3.7312 (3.2); 3.7168 (3.1); 3.3081 (11.9); 2.5228 (1.6); 2.5181 (2.3); 2.5094 (22.2); 2.5049 (45.4); 2,5003 (62.0); 2.4957 (42.0); 2.4912 (18.6); 1.9876 (5.7); 1.9256 (6.2); 1.9243 (6.1); 1.9079

(3.0) ; 1.7250 (16.0); 1.1923 (1.7); 1.1745 (3.4); 1.1567 (1.7); 0.0080 (0.6); -0.0002 (18.1) (3.0); 1.7250 (16.0); 1.1923 (1.7); 1.1745 (3.4); 1.1567 (1.7); 0.0080 (0.6); -0.0002 (18.1)

1.71-176: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-176: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8440 (5.7); 7.8420 (5.5); 7.5556 (0.6); 7.5392 (1.2); 7.5346 (0.9); 7.5226 (0.8); 7.5180 (2.2); 7.5134 (0.8); 7.5014 (1.0); 7.4970 (1.4); 7.4806 (0.6); 7.3874 (1.7); 7.3696 (1.6); 7.2328 (0.5); 7.2222 (3.1); 7.2021 (4.4); 7.1818δ = 7.8440 (5.7); 7.8420 (5.5); 7.5556 (0.6); 7.5392 (1.2); 7.5346 (0.9); 7.5226 (0.8); 7.5180 (2.2); 7.5134 (0.8); 7.5014 (1.0); 7.4970 (1.4); 7.4806 (0.6); 7.3874 (1.7); 7.3696 (1.6); 7.2328 (0.5); 7.2222 (3.1); 7.2021 (4.4); 7.1818

(2.6) ; 4.1931 (1.9); 4.1750 (3.0); 4.1569 (1.9); 4.0560 (0.8); 4.0382 (2.4); 4.0204 (2.4); 4.0025 (0.8); 3.3082 (83.0); 3.2593 (0.5); 2.6740 (1.4); 2.6693 (1.9); 2.6647 (1.4); 2.5561 (1.3); 2.5514 (1.3); 2.5465 (0.8); 2.5228 (6.6); 2.5181(2.6); 4.1931 (1.9); 4.1750 (3.0); 4.1569 (1.9); 4.0560 (0.8); 4.0382 (2.4); 4.0204 (2.4); 4.0025 (0.8); 3.3082 (83.0); 3.2593 (0.5); 2.6740 (1.4); 2.6693 (1.9); 2.6647 (1.4); 2.5561 (1.3); 2.5514 (1.3); 2.5465 (0.8); 2.5228 (6.6); 2.5181

(9.5) ; 2.5094 (107.8); 2.5048 (222.7); 2.5002 (306.2); 2.4957 (209.2); 2.4911 (94.2); 2.4552 (1.2); 2.3364 (0.6); 2.3317 (1.3); 2.3270 (1.9); 2.3224 (1.3); 2.3178 (0.6); 1.9877 (11.3); 1.9289 (13.4); 1.9078 (8.4); 1.7326 (15.5); 1.7233 (16.0); 1.3553 (1.1); 1.2406 (11.0); 1.2224 (10.8); 1.1923 (3.3); 1.1745 (6.7); 1.1567 (3.3); 0.0080 (2.5); -(9.5); 2.5094 (107.8); 2.5048 (222.7); 2.5002 (306.2); 2.4957 (209.2); 2.4911 (94.2); 2.4552 (1.2); 2.3364 (0.6); 2.3317 (1.3); 2.3270 (1.9); 2.3224 (1.3); 2.3178 (0.6); 1.9877 (11.3); 1.9289 (13.4); 1.9078 (8.4); 1.7326 (15.5); 1.7233 (16.0); 1.3553 (1.1); 1.2406 (11.0); 1.2224 (10.8); 1.1923 (3.3); 1.1745 (6.7); 1.1567 (3.3); 0.0080 (2.5); -

0.0002 (86.8); -0.0085 (2.6) 0.0002 (86.8); -0.0085 (2.6)

1.71-177: 1 H-NMR(400.0 MHz, CDCI3):  1.71-177: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5288 (2.6); 7.3543 (0.8); 7.3376 (0.5); 7.2607 (13.1); 7.2255 (1.3); 7.0200 (1.3); 7.0011 (2.0); 6.9812 (1.1);δ = 7.5288 (2.6); 7.3543 (0.8); 7.3376 (0.5); 7.2607 (13.1); 7.2255 (1.3); 7.0200 (1.3); 7.0011 (2.0); 6.9812 (1.1);

2.0294 (7.1); 1.8639 (16.0); 1.4741 (15.9); 1.2583 (0.8); -0.0002 (4.0) 2.0294 (7.1); 1.8639 (16.0); 1.4741 (15.9); 1.2583 (0.8); -0.0002 (4.0)

1.71-178: 1 H-NMR(400.0 MHz, CDCI3):  1.71-178: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5182 (0.9); 7.5002 (1.6); 7.4984 (1.6); 7.3456 (0.8); 7.2593 (151.1); 7.2338 (1.8); 7.2250 (1.0); 7.0177 (1.0); 6.9955 (1.6); 6.9780 (0.8); 3.6013 (9.3); 3.4694 (0.7); 3.4529 (1.6); 3.4378 (1.7); 3.4213 (0.7); 2.4932 (1.3); 2.4766δ = 7.5182 (0.9); 7.5002 (1.6); 7.4984 (1.6); 7.3456 (0.8); 7.2593 (151.1); 7.2338 (1.8); 7.2250 (1.0); 7.0177 (1.0); 6.9955 (1.6); 6.9780 (0.8); 3.6013 (9.3); 3.4694 (0.7); 3.4529 (1.6); 3.4378 (1.7); 3.4213 (0.7); 2.4932 (1.3); 2.4766

(2.6) ; 2.4599 (1.2); 2.0271 (4.5); 2.0253 (4.3); 1.8537 (16.0); 1.5299 (12.6); 0.0079 (2.3); -0.0002 (64.0); -0.0085(2.6); 2.4599 (1.2); 2.0271 (4.5); 2.0253 (4.3); 1.8537 (16.0); 1.5299 (12.6); 0.0079 (2.3); -0.0002 (64.0); -0.0085

(2.6); -0.0257 (0.8) (2.6); -0.0257 (0.8)

1.71-179: 1 H-NMR(400.0 MHz, CDCI3):  1.71-179: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5181 (2.9); 7.3479 (2.2); 7.3319 (1.0); 7.3270 (0.7); 7.3112 (0.7); 7.3086 (1.6); 7.2952 (1.3); 7.2900 (1.4); 7.2818 (1.0); 7.2737 (1.9); 7.2592 (490.3); 7.2083 (1.4); 6.9952 (2.9); 6.9752 (2.1); 6.9565 (2.4); 6.9357 (1.8); 4.1273δ = 7.5181 (2.9); 7.3479 (2.2); 7.3319 (1.0); 7.3270 (0.7); 7.3112 (0.7); 7.3086 (1.6); 7.2952 (1.3); 7.2900 (1.4); 7.2818 (1.0); 7.2737 (1.9); 7.2592 (490.3); 7.2083 (1.4); 6.9952 (2.9); 6.9752 (2.1); 6.9565 (2.4); 6.9357 (1.8); 4.1273

(1.1) ; 4.1105 (1.1); 3.6880 (0.7); 3.6191 (0.6); 2.5953 (0.6); 2.4876 (1.2); 2.0048 (0.8); 1.9941 (10.0); 1.9925 (10.0); 1.8180 (16.0); 1.5305 (14.7); 1.2598 (1.5); 1.2421 (2.4); 1.2255 (1.3); 0.1461 (0.6); 0.0080 (5.6); -0.0002 (189.0); -(1.1); 4.1105 (1.1); 3.6880 (0.7); 3.6191 (0.6); 2.5953 (0.6); 2.4876 (1.2); 2.0048 (0.8); 1.9941 (10.0); 1.9925 (10.0); 1.8180 (16.0); 1.5305 (14.7); 1.2598 (1.5); 1.2421 (2.4); 1.2255 (1.3); 0.1461 (0.6); 0.0080 (5.6); -0.0002 (189.0); -

0.0085 (5.8); -0.0511 (0.5); -0.1496 (0.6) 0.0085 (5.8); -0.0511 (0.5); -0.1496 (0.6)

1.71-180: 1 H-NMR(400.0 MHz, CDCI3):  1.71-180: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5037 (4.0); 7.5018 (4.1); 7.3692 (0.9); 7.3642 (0.8); 7.3533 (0.6); 7.3482 (1.8); 7.3431 (0.7); 7.3321 (0.8); 7.3272 (1.2); 7.3112 (0.6); 7.2606 (49.9); 7.0175 (2.4); 6.9982 (3.0); 6.9967 (3.1); 6.9882 (0.6); 6.9777 (2.2); 6.7341 (0.6); 6.7141 (0.7); 4.2604 (0.7); 4.2432 (0.9); 4.2259 (0.7); 4.0976 (1.6); 4.0798 (4.9); 4.0619 (5.2); 4.0441 (1.8); 2.4934 (1.1); 2.4792 (1.1); 2.4555 (2.2); 2.4414 (2.2); 2.3843 (2.2); 2.3667 (2.3); 2.3465 (1.2); 2.3289 (1.2); 2.0242 (10.7); 2.0225 (11.1); 1.8513 (15.2); 1.8439 (16.0); 1.8252 (0.8); 1.5580 (3.0); 1.2616 (0.6); 1.2191 (6.6); 1.2013δ = 7.5037 (4.0); 7.5018 (4.1); 7.3692 (0.9); 7.3642 (0.8); 7.3533 (0.6); 7.3482 (1.8); 7.3431 (0.7); 7.3321 (0.8); 7.3272 (1.2); 7.3112 (0.6); 7.2606 (49.9); 7.0175 (2.4); 6.9982 (3.0); 6.9967 (3.1); 6.9882 (0.6); 6.9777 (2.2); 6.7341 (0.6); 6.7141 (0.7); 4.2604 (0.7); 4.2432 (0.9); 4.2259 (0.7); 4.0976 (1.6); 4.0798 (4.9); 4.0619 (5.2); 4.0441 (1.8); 2.4934 (1.1); 2.4792 (1.1); 2.4555 (2.2); 2.4414 (2.2); 2.3843 (2.2); 2.3667 (2.3); 2.3465 (1.2); 2.3289 (1.2); 2.0242 (10.7); 2.0225 (11.1); 1.8513 (15.2); 1.8439 (16.0); 1.8252 (0.8); 1.5580 (3.0); 1.2616 (0.6); 1.2191 (6.6); 1.2013

(13.6); 1.1835 (6.6); 1.1433 (8.3); 1.1265 (8.5); -0.0002 (17.4); -0.0085 (0.9) (13.6); 1.1835 (6.6); 1.1433 (8.3); 1.1265 (8.5); -0.0002 (17.4); -0.0085 (0.9)

1.71-181 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-181: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5186 (0.7); 7.3590 (1.0); 7.3476 (1.0); 7.3316 (1.9); 7.3268 (1.2); 7.3155 (1.0); 7.3106 (2.3); 7.3056 (0.9); 7.2945 (1.2); 7.2896 (1.4); 7.2737 (0.9); 7.2597 (121.1); 6.9957 (0.8); 6.9733 (2.5); 6.9545 (3.2); 6.9342 (2.2); 4.1148 (1.4); 4.0999 (1.4); 2.4144 (0.6); 2.3165 (2.0); 2.1945 (0.6); 2.1044 (0.6); 2.0451 (0.6); 1.9896 (13.9); 1.8282 (8.9); 1.8177 (16.0); 1.2591 (1.8); 1.2415 (2.4); 1.1856 (1.6); 0.0080 (1.4); -0.0002 (50.1); -0.0085 (1.5) 1.71-182: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5186 (0.7); 7.3590 (1.0); 7.3476 (1.0); 7.3316 (1.9); 7.3268 (1.2); 7.3155 (1.0); 7.3106 (2.3); 7.3056 (0.9); 7.2945 (1.2); 7.2896 (1.4); 7.2737 (0.9); 7.2597 (121.1); 6.9957 (0.8); 6.9733 (2.5); 6.9545 (3.2); 6.9342 (2.2); 4.1148 (1.4); 4.0999 (1.4); 2.4144 (0.6); 2.3165 (2.0); 2.1945 (0.6); 2.1044 (0.6); 2.0451 (0.6); 1.9896 (13.9); 1.8282 (8.9); 1.8177 (16.0); 1.2591 (1.8); 1.2415 (2.4); 1.1856 (1.6); 0.0080 (1.4); -0.0002 (50.1); -0.0085 (1.5) 1.71-182: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5159 (4.2); 7.5139 (4.4); 7.3715 (1.0); 7.3663 (0.9); 7.3555 (0.6); 7.3504 (1.9); 7.3455 (0.8); 7.3342 (0.9); 7.3294 (1.2); 7.3134 (0.6); 7.2611 (37.6); 7.0171 (2.5); 7.0106 (0.5); 7.0067 (0.5); 6.9977 (3.2); 6.9967 (3.2); 6.9879 (0.6); 6.9835 (0.5); 6.9772 (2.4); 6.4887 (0.7); 6.4678 (0.7); 4.1126 (2.0); 4.0947 (6.1); 4.0769 (6.3); 4.0590 (2.1); 3.9140 (0.6); 3.8983 (0.7); 3.8835 (0.6); 2.2229 (2.4); 2.2035 (5.0); 2.1834 (3.2); 2.0263 (11.2); 2.0245 (11.8); 1.8902 (0.8); 1.8627 (15.5); 1.8530 (16.0); 1.7821 (0.6); 1.7679 (1.0); 1.7539 (0.6); 1.7473 (1.1); 1.7336 (0.9); 1.7271 (0.5); 1.6564 (0.5); 1.6355 (1.0); 1.6174 (1.0); 1.6019 (0.8); 1.5966 (0.6); 1.5813 (0.8); 1.5697 (8.6); 1.5619 (0.6); 1.2327δ = 7.5159 (4.2); 7.5139 (4.4); 7.3715 (1.0); 7.3663 (0.9); 7.3555 (0.6); 7.3504 (1.9); 7.3455 (0.8); 7.3342 (0.9); 7.3294 (1.2); 7.3134 (0.6); 7.2611 (37.6); 7.0171 (2.5); 7.0106 (0.5); 7.0067 (0.5); 6.9977 (3.2); 6.9967 (3.2); 6.9879 (0.6); 6.9835 (0.5); 6.9772 (2.4); 6.4887 (0.7); 6.4678 (0.7); 4.1126 (2.0); 4.0947 (6.1); 4.0769 (6.3); 4.0590 (2.1); 3.9140 (0.6); 3.8983 (0.7); 3.8835 (0.6); 2.2229 (2.4); 2.2035 (5.0); 2.1834 (3.2); 2.0263 (11.2); 2.0245 (11.8); 1.8902 (0.8); 1.8627 (15.5); 1.8530 (16.0); 1.7821 (0.6); 1.7679 (1.0); 1.7539 (0.6); 1.7473 (1.1); 1.7336 (0.9); 1.7271 (0.5); 1.6564 (0.5); 1.6355 (1.0); 1.6174 (1.0); 1.6019 (0.8); 1.5966 (0.6); 1.5813 (0.8); 1.5697 (8.6); 1.5619 (0.6); 1.2327

(7.3) ; 1.2149 (15.0); 1.1970 (7.2); 1.0698 (9.0); 1.0532 (9.0); -0.0002 (13.2); -0.0085 (0.6) (7.3); 1.2149 (15.0); 1.1970 (7.2); 1.0698 (9.0); 1.0532 (9.0); -0.0002 (13.2); -0.0085 (0.6)

1.71-183: 1 H-NMR(400.0 MHz, CDCI3):  1.71-183: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5186 (0.5); 7.5028 (4.4); 7.5011 (4.4); 7.3710 (1.0); 7.3660 (0.9); 7.3551 (0.6); 7.3499 (2.0); 7.3450 (0.7); 7.3340 (0.9); 7.3289 (1.1); 7.3128 (0.6); 7.2597 (87.0); 7.0177 (2.7); 6.9983 (3.3); 6.9885 (0.6); 6.9780 (2.4); 6.8324 (0.8); 6.8133 (0.8); 4.2377 (0.8); 4.2205 (1.0); 4.2041 (0.8); 2.5437 (1.1); 2.5297 (1.1); 2.5046 (2.4); 2.4907 (2.4); 2.4485 (2.4); 2.4321 (2.4); 2.4094 (1.1); 2.3931 (1.1); 2.0438 (1.7); 2.0179 (12.0); 1.8553 (16.0); 1.8445 (16.0); 1.8244 (0.6); 1.4320 (0.8); 1.2763 (0.5); 1.2584 (1.4); 1.2431 (2.4); 1.2228 (2.7); 1.1754 (8.4); 1.1585 (8.4); 0.0080δ = 7.5186 (0.5); 7.5028 (4.4); 7.5011 (4.4); 7.3710 (1.0); 7.3660 (0.9); 7.3551 (0.6); 7.3499 (2.0); 7.3450 (0.7); 7.3340 (0.9); 7.3289 (1.1); 7.3128 (0.6); 7.2597 (87.0); 7.0177 (2.7); 6.9983 (3.3); 6.9885 (0.6); 6.9780 (2.4); 6.8324 (0.8); 6.8133 (0.8); 4.2377 (0.8); 4.2205 (1.0); 4.2041 (0.8); 2.5437 (1.1); 2.5297 (1.1); 2.5046 (2.4); 2.4907 (2.4); 2.4485 (2.4); 2.4321 (2.4); 2.4094 (1.1); 2.3931 (1.1); 2.0438 (1.7); 2.0179 (12.0); 1.8553 (16.0); 1.8445 (16.0); 1.8244 (0.6); 1.4320 (0.8); 1.2763 (0.5); 1.2584 (1.4); 1.2431 (2.4); 1.2228 (2.7); 1.1754 (8.4); 1.1585 (8.4); 0.0080

(1.0); -0.0002 (31.5); -0.0084 (1.1) (1.0); -0.0002 (31.5); -0.0084 (1.1)

1.71-184: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-184: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7842 (1.1); 7.7822 (1.2); 7.7682 (2.6); 7.5452 (0.7); 7.5287 (1.5); 7.5241 (1.2); 7.5122 (1.0); 7.5077 (2.6); 7.5031 (1.0); 7.4912 (1.3); 7.4866 (1.6); 7.4703 (0.8); 7.2194 (0.5); 7.2089 (3.4); 7.1890 (5.0); 7.1690 (2.8); 6.6250 (0.5); 5.7528 (0.8); 3.9194 (0.8); 3.5044 (1.5); 3.4775 (1.4); 3.4643 (1.2); 3.3724 (0.5); 3.1291 (0.6); 2.6745 (0.7); 2.6699 (1.0); 2.6653 (0.7); 2.5234 (2.5); 2.5187 (3.6); 2.5100 (50.9); 2.5054 (108.6); 2.5008 (152.4); 2.4962 (106.0); 2.4917 (49.2); 2.3448 (1.8); 2.3372 (1.8); 2.3324 (1.8); 2.3276 (1.8); 2.3230 (1.3); 2.2220 (0.6); 2.1782 (2.4); 2.1234 (1.0); 2.0724 (0.7); 1.9879 (1.8); 1.9171 (15.7); 1.9084 (3.7); 1.7341 (0.6); 1.6786 (16.0); 1.3559 (2.6); 1.2695 (0.8); 1.2356 (1.0); 1.1926 (0.8); 1.1813 (3.6); 1.1748 (1.6); 1.1695 (1.4); 1.1570 (1.0); 1.0258 (1.7); 0.8737 (0.8); -0.0002δ = 7.7842 (1.1); 7.7822 (1.2); 7.7682 (2.6); 7.5452 (0.7); 7.5287 (1.5); 7.5241 (1.2); 7.5122 (1.0); 7.5077 (2.6); 7.5031 (1.0); 7.4912 (1.3); 7.4866 (1.6); 7.4703 (0.8); 7.2194 (0.5); 7.2089 (3.4); 7.1890 (5.0); 7.1690 (2.8); 6.6250 (0.5); 5.7528 (0.8); 3.9194 (0.8); 3.5044 (1.5); 3.4775 (1.4); 3.4643 (1.2); 3.3724 (0.5); 3.1291 (0.6); 2.6745 (0.7); 2.6699 (1.0); 2.6653 (0.7); 2.5234 (2.5); 2.5187 (3.6); 2,5100 (50.9); 2.5054 (108.6); 2.5008 (152.4); 2.4962 (106.0); 2.4917 (49.2); 2.3448 (1.8); 2.3372 (1.8); 2.3324 (1.8); 2.3276 (1.8); 2.3230 (1.3); 2.2220 (0.6); 2.1782 (2.4); 2.1234 (1.0); 2.0724 (0.7); 1.9879 (1.8); 1.9171 (15.7); 1.9084 (3.7); 1.7341 (0.6); 1.6786 (16.0); 1.3559 (2.6); 1.2695 (0.8); 1.2356 (1.0); 1.1926 (0.8); 1.1813 (3.6); 1.1748 (1.6); 1.1695 (1.4); 1.1570 (1.0); 1.0258 (1.7); 0.8737 (0.8); -0.0002

(3-8) (3-8)

1.71-185: 1 H-NMR(400.0 MHz, CDCI3):  1.71-185: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5226 (4.6); 7.3783 (0.9); 7.3731 (0.9); 7.3573 (1.7); 7.3412 (0.9); 7.3362 (1.1); 7.3204 (0.5); 7.2597 (66.2); 7.0219 (2.5); 7.0023 (3.5); 6.9826 (2.3); 6.7142 (0.9); 6.6921 (0.9); 3.9481 (0.6); 2.2987 (1.1); 2.2835 (1.4); 2.2799δ = 7.5226 (4.6); 7.3783 (0.9); 7.3731 (0.9); 7.3573 (1.7); 7.3412 (0.9); 7.3362 (1.1); 7.3204 (0.5); 7.2597 (66.2); 7.0219 (2.5); 7.0023 (3.5); 6.9826 (2.3); 6.7142 (0.9); 6.6921 (0.9); 3.9481 (0.6); 2.2987 (1.1); 2.2835 (1.4); 2.2799

(1.4) ; 2.2650 (1.5); 2.2486 (1.9); 2.2289 (1.4); 2.2091 (0.6); 2.0277 (12.9); 1.8726 (16.0); 1.8642 (15.9); 1.8388 (0.6); 1.8308 (0.7); 1.8193 (0.7); 1.7951 (0.9); 1.7842 (0.9); 1.6298 (0.7); 1.6242 (0.5); 1.6133 (0.9); 1.5898 (0.8); 1.4320(1.4); 2.2650 (1.5); 2.2486 (1.9); 2.2289 (1.4); 2.2091 (0.6); 2.0277 (12.9); 1.8726 (16.0); 1.8642 (15.9); 1.8388 (0.6); 1.8308 (0.7); 1.8193 (0.7); 1.7951 (0.9); 1.7842 (0.9); 1.6298 (0.7); 1.6242 (0.5); 1.6133 (0.9); 1.5898 (0.8); 1.4320

(0.5); 1.2556 (0.7); 1.2431 (1.7); 1.2228 (0.6); 1.0989 (8.2); 1.0823 (8.1); -0.0002 (24.0); -0.0081 (0.9) (0.5); 1.2556 (0.7); 1.2431 (1.7); 1.2228 (0.6); 1.0989 (8.2); 1.0823 (8.1); -0.0002 (24.0); -0.0081 (0.9)

1.71-186: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-186: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 11.7116 (4.0); 7.8049 (0.5); 7.7779 (3.2); 7.5481 (0.6); 7.5316 (1.3); 7.5267 (1.1); 7.5151 (1.0); 7.5105 (2.3); 7.4938 (1.2); 7.4895 (1.5); 7.4731 (0.7); 7.2106 (3.2); 7.2004 (1.1); 7.1906 (4.9); 7.1804 (1.4); 7.1705 (3.0); 7.1596 (0.8); 3.5455 (2.0); 3.1917 (23.3); 3.1688 (10.5); 2.6742 (0.7); 2.6696 (0.9); 2.6651 (0.7); 2.5231 (3.2); 2.5184 (4.9); 2.5096 (61.0); 2.5051 (125.4); 2.5006 (171.0); 2.4960 (122.0); 2.4915 (60.6); 2.4180 (2.2); 2.3989 (2.3); 2.3319 (1.1); 2.3273 (1.4); 2.3228 (1.1); 2.1794 (2.4); 1.9196 (16.0); 1.7342 (3.4); 1.6860 (7.6); 1.6391 (3.4); 1.2357 (1.4); 1.0264δ = 11.7116 (4.0); 7.8049 (0.5); 7.7779 (3.2); 7.5481 (0.6); 7.5316 (1.3); 7.5267 (1.1); 7.5151 (1.0); 7.5105 (2.3); 7.4938 (1.2); 7.4895 (1.5); 7.4731 (0.7); 7.2106 (3.2); 7.2004 (1.1); 7.1906 (4.9); 7.1804 (1.4); 7.1705 (3.0); 7.1596 (0.8); 3.5455 (2.0); 3.1917 (23.3); 3.1688 (10.5); 2.6742 (0.7); 2.6696 (0.9); 2.6651 (0.7); 2.5231 (3.2); 2.5184 (4.9); 2.5096 (61.0); 2.5051 (125.4); 2,5006 (171.0); 2.4960 (122.0); 2.4915 (60.6); 2.4180 (2.2); 2.3989 (2.3); 2.3319 (1.1); 2.3273 (1.4); 2.3228 (1.1); 2.1794 (2.4); 1.9196 (16.0); 1.7342 (3.4); 1.6860 (7.6); 1.6391 (3.4); 1.2357 (1.4); 1.0264

(2.0) ; 0.0080 (3.5); 0.0063 (1.8); -0.0002 (100.9); -0.0085 (4.3); -0.0339 (0.7) (2.0); 0.0080 (3.5); 0.0063 (1.8); -0.0002 (100.9); -0.0085 (4.3); -0.0339 (0.7)

1.71-187: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-187: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.1058 (1.6); 10.0546 (1.2); 10.0463 (1.3); 9.4020 (2.7); 9.3941 (2.4); 7.8011 (3.3); 7.7990 (4.2); 7.7957 (5.7); 7.5459 (0.6); 7.5293 (1.2); 7.5236 (1.5); 7.5184 (0.8); 7.5129 (0.9); 7.5082 (2.4); 7.5023 (1.8); 7.4915 (1.2); 7.4870 (1.9); 7.4811 (0.9); 7.4708 (0.7); 7.2082 (2.7); 7.2018 (2.5); 7.1884 (4.3); 7.1818 (3.5); 7.1686 (2.6); 7.1615 (1.9); 3.9643 (1.7); 3.1689 (13.8); 2.9788 (1.1); 2.9047 (3.9); 2.8581 (14.0); 2.6744 (0.8); 2.6697 (1.3); 2.6650 (0.9); 2.5232δ = 10.1058 (1.6); 10.0546 (1.2); 10.0463 (1.3); 9.4020 (2.7); 9.3941 (2.4); 7.8011 (3.3); 7.7990 (4.2); 7.7957 (5.7); 7.5459 (0.6); 7.5293 (1.2); 7.5236 (1.5); 7.5184 (0.8); 7.5129 (0.9); 7.5082 (2.4); 7.5023 (1.8); 7.4915 (1.2); 7.4870 (1.9); 7.4811 (0.9); 7.4708 (0.7); 7.2082 (2.7); 7.2018 (2.5); 7.1884 (4.3); 7.1818 (3.5); 7.1686 (2.6); 7.1615 (1.9); 3.9643 (1.7); 3.1689 (13.8); 2.9788 (1.1); 2.9047 (3.9); 2.8581 (14.0); 2.6744 (0.8); 2.6697 (1.3); 2.6650 (0.9); 2.5232

(2.5) ; 2.5185 (3.7); 2.5098 (71.0); 2.5052 (155.4); 2.5006 (219.4); 2.4960 (154.2); 2.4915 (72.9); 2.4708 (2.1); 2.3367 (0.8); 2.3320 (1.4); 2.3274 (1.8); 2.3228 (1.4); 2.3182 (0.9); 2.2708 (1.9); 2.1877 (2.4); 2.1234 (0.6); 1.9201 (14.4); 1.9082 (2.0); 1.7494 (16.0); 1.7032 (3.5); 1.6426 (2.6); 1.2588 (0.6); 1.2361 (2.5); 1.0223 (1.7); 0.8736 (0.8); 0.8542(2.5); 2.5185 (3.7); 2.5098 (71.0); 2.5052 (155.4); 2,5006 (219.4); 2.4960 (154.2); 2.4915 (72.9); 2.4708 (2.1); 2.3367 (0.8); 2.3320 (1.4); 2.3274 (1.8); 2.3228 (1.4); 2.3182 (0.9); 2.2708 (1.9); 2.1877 (2.4); 2.1234 (0.6); 1.9201 (14.4); 1.9082 (2.0); 1.7494 (16.0); 1.7032 (3.5); 1.6426 (2.6); 1.2588 (0.6); 1.2361 (2.5); 1.0223 (1.7); 0.8736 (0.8); 0.8542

(0.7); 0.0080 (4.1); -0.0002 (149.4); -0.0085 (5.0); -0.1497 (0.5) (0.7); 0.0080 (4.1); -0.0002 (149.4); -0.0085 (5.0); -0.1497 (0.5)

1.71-188: 1 H-NMR(400.0 MHz, CDCI3):  1.71-188: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5192 (0.8); 7.3757 (1.5); 7.3490 (0.6); 7.3331 (1.1); 7.3280 (1.0); 7.3173 (0.7); 7.3121 (2.2); 7.3070 (0.8); 7.2961 (1.0); 7.2910 (1.4); 7.2752 (0.8); 7.2602 (101.0); 6.9962 (0.6); 6.9713 (2.7); 6.9613 (0.5); 6.9524 (3.2); 6.9506δ = 7.5192 (0.8); 7.3757 (1.5); 7.3490 (0.6); 7.3331 (1.1); 7.3280 (1.0); 7.3173 (0.7); 7.3121 (2.2); 7.3070 (0.8); 7.2961 (1.0); 7.2910 (1.4); 7.2752 (0.8); 7.2602 (101.0); 6.9962 (0.6); 6.9713 (2.7); 6.9613 (0.5); 6.9524 (3.2); 6.9506

(3.1) ; 6.9421 (0.5); 6.9319 (2.4); 3.7554 (0.5); 3.6690 (1.6); 3.6408 (2.0); 3.6252 (2.1); 3.5615 (0.9); 3.5492 (0.7); 2.3351 (3.7); 2.0938 (0.6); 2.0496 (0.6); 2.0473 (0.6); 1.9976 (8.8); 1.8792 (2.7); 1.8064 (16.0); 1.7959 (5.2); 1.2844 (0.8); 1.2561 (5.9); 1.2347 (2.7); 1.2187 (2.7); 0.8802 (1.1); 0.8748 (0.8); 0.8701 (0.6); 0.8625 (0.7); 0.8532 (1.0);(3.1); 6.9421 (0.5); 6.9319 (2.4); 3.7554 (0.5); 3.6690 (1.6); 3.6408 (2.0); 3.6252 (2.1); 3.5615 (0.9); 3.5492 (0.7); 2.3351 (3.7); 2.0938 (0.6); 2.0496 (0.6); 2.0473 (0.6); 1.9976 (8.8); 1.8792 (2.7); 1.8064 (16.0); 1.7959 (5.2); 1.2844 (0.8); 1.2561 (5.9); 1.2347 (2.7); 1.2187 (2.7); 0.8802 (1.1); 0.8748 (0.8); 0.8701 (0.6); 0.8625 (0.7); 0.8532 (1.0);

0.8364 (0.8); 0.0080 (0.8); -0.0002 (38.4); -0.0085 (1.5) 0.8364 (0.8); 0.0080 (0.8); -0.0002 (38.4); -0.0085 (1.5)

1.71-189: 1 H-NMR(400.0 MHz, CDCI3):  1.71-189: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5183 (1.9); 7.5165 (1.7); 7.3493 (0.9); 7.3282 (0.6); 7.2602 (20.6); 7.0183 (1.1); 6.9989 (1.4); 6.9786 (0.9); 3.4027 (0.8); 3.3859 (1.2); 3.3712 (1.2); 3.3685 (1.1); 3.3533 (0.8); 2.5581 (1.5); 2.5403 (2.1); 2.5231 (1.4); 2.0581δ = 7.5183 (1.9); 7.5165 (1.7); 7.3493 (0.9); 7.3282 (0.6); 7.2602 (20.6); 7.0183 (1.1); 6.9989 (1.4); 6.9786 (0.9); 3.4027 (0.8); 3.3859 (1.2); 3.3712 (1.2); 3.3685 (1.1); 3.3533 (0.8); 2.5581 (1.5); 2.5403 (2.1); 2.5231 (1.4); 2.0581

(11.3); 2.0276 (5.0); 2.0261 (4.6); 1.8728 (16.0); 1.5481 (3.7); -0.0002 (7.4) (11.3); 2.0276 (5.0); 2.0261 (4.6); 1.8728 (16.0); 1.5481 (3.7); -0.0002 (7.4)

1.71-190: 1 H-NMR(400.0 MHz, CDCI3):  1.71-190: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3859 (1.4); 7.3845 (1.4); 7.3138 (0.8); 7.2928 (0.6); 7.2605 (21.0); 6.9792 (1.0); 6.9603 (1.2); 6.9583 (1.1);δ = 7.3859 (1.4); 7.3845 (1.4); 7.3138 (0.8); 7.2928 (0.6); 7.2605 (21.0); 6.9792 (1.0); 6.9603 (1.2); 6.9583 (1.1);

6.9396 (0.9); 2.4936 (0.9); 2.1587 (1.0); 1.9996 (4.8); 1.9980 (4.8); 1.8299 (16.0); -0.0002 (8.1) 6.9396 (0.9); 2.4936 (0.9); 2.1587 (1.0); 1.9996 (4.8); 1.9980 (4.8); 1.8299 (16.0); -0.0002 (8.1)

1.71-191 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-191: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5138 (2.1); 7.5121 (1.8); 7.3836 (0.5); 7.3626 (0.9); 7.3467 (0.5); 7.3415 (0.6); 7.2602 (27.2); 7.0324 (1.3); 7.0129 (1.6); 6.9926 (1.0); 3.6843 (0.7); 3.6681 (1.7); 3.6529 (1.9); 3.6366 (0.7); 3.2070 (1.1); 3.1906 (2.0); 3.1740 (0.9); 2.8614 (7.4); 2.0283 (5.6); 1.8619 (16.0); 1.5472 (4.4); 0.0080 (0.5); -0.0002 (9.6) 1.71-193: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5138 (2.1); 7.5121 (1.8); 7.3836 (0.5); 7.3626 (0.9); 7.3467 (0.5); 7.3415 (0.6); 7.2602 (27.2); 7.0324 (1.3); 7.0129 (1.6); 6.9926 (1.0); 3.6843 (0.7); 3.6681 (1.7); 3.6529 (1.9); 3.6366 (0.7); 3.2070 (1.1); 3.1906 (2.0); 3.1740 (0.9); 2.8614 (7.4); 2.0283 (5.6); 1.8619 (16.0); 1.5472 (4.4); 0.0080 (0.5); -0.0002 (9.6) 1.71-193: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5144 (1.7); 7.5125 (1.7); 7.3547 (0.8); 7.2602 (8.1); 7.0246 (1.0); 7.0054 (1.2); 6.9847 (0.9); 5.7665 (0.8); 3.5586 (0.7); 3.5478 (0.8); 3.5432 (0.8); 3.5325 (0.7); 2.0309 (4.5); 2.0291 (4.6); 1.8761 (16.0); 1.5617 (0.7); -0.0002δ = 7.5144 (1.7); 7.5125 (1.7); 7.3547 (0.8); 7.2602 (8.1); 7.0246 (1.0); 7.0054 (1.2); 6.9847 (0.9); 5.7665 (0.8); 3.5586 (0.7); 3.5478 (0.8); 3.5432 (0.8); 3.5325 (0.7); 2.0309 (4.5); 2.0291 (4.6); 1.8761 (16.0); 1.5617 (0.7); -0.0002

(3-0) (3-0)

1.71-194: 1 H-NMR(400.0 MHz, CDCI3):  1.71-194: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3696 (1.4); 7.3680 (1.4); 7.3199 (0.7); 7.2989 (0.5); 7.2595 (61.6); 6.9822 (1.0); 6.9635 (1.2); 6.9615 (1.0); 6.9428 (0.9); 3.7180 (2.2); 2.5717 (0.6); 2.0034 (5.0); 2.0018 (4.9); 1.8713 (3.3); 1.8391 (16.0); 1.5385 (11.6); 0.0079δ = 7.3696 (1.4); 7.3680 (1.4); 7.3199 (0.7); 7.2989 (0.5); 7.2595 (61.6); 6.9822 (1.0); 6.9635 (1.2); 6.9615 (1.0); 6.9428 (0.9); 3.7180 (2.2); 2.5717 (0.6); 2.0034 (5.0); 2.0018 (4.9); 1.8713 (3.3); 1.8391 (16.0); 1.5385 (11.6); 0.0079

(0.7); -0.0002 (22.4); -0.0085 (0.7) (0.7); -0.0002 (22.4); -0.0085 (0.7)

1.71-195: 1 H-NMR(400.0 MHz, CDCI3):  1.71-195: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5202 (1.7); 7.5183 (1.7); 7.3582 (0.8); 7.2599 (10.0); 7.0262 (1.0); 7.0069 (1.2); 7.0056 (1.2); 6.9862 (0.9); 3.8461 (1.0); 3.8299 (1.0); 3.8234 (1.0); 3.8073 (1.0); 2.0337 (4.3); 2.0317 (4.5); 1.8849 (16.0); 1.5516 (1.3); -0.0002δ = 7.5202 (1.7); 7.5183 (1.7); 7.3582 (0.8); 7.2599 (10.0); 7.0262 (1.0); 7.0069 (1.2); 7.0056 (1.2); 6.9862 (0.9); 3.8461 (1.0); 3.8299 (1.0); 3.8234 (1.0); 3.8073 (1.0); 2.0337 (4.3); 2.0317 (4.5); 1.8849 (16.0); 1.5516 (1.3); -0.0002

(3-8) (3-8)

1.71-196: 1 H-NMR(400.0 MHz, CDCI3):  1.71-196: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5152 (1.7); 7.5134 (1.6); 7.3504 (0.8); 7.2597 (26.5); 7.0120 (1.0); 6.9930 (1.2); 6.9912 (1.1); 6.9724 (0.9);δ = 7.5152 (1.7); 7.5134 (1.6); 7.3504 (0.8); 7.2597 (26.5); 7.0120 (1.0); 6.9930 (1.2); 6.9912 (1.1); 6.9724 (0.9);

2.0165 (4.6); 2.0148 (4.6); 1.8466 (16.0); 1.5384 (6.8); 1.4989 (8.4); 1.4974 (8.4); -0.0002 (9.8) 2.0165 (4.6); 2.0148 (4.6); 1.8466 (16.0); 1.5384 (6.8); 1.4989 (8.4); 1.4974 (8.4); -0.0002 (9.8)

1.71-197: 1 H-NMR(400.0 MHz, CDCI3):  1.71-197: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3634 (1.4); 7.3614 (1.4); 7.3219 (0.8); 7.2599 (25.2); 6.9827 (0.9); 6.9638 (1.0); 6.9617 (0.9); 6.9429 (0.8);δ = 7.3634 (1.4); 7.3614 (1.4); 7.3219 (0.8); 7.2599 (25.2); 6.9827 (0.9); 6.9638 (1.0); 6.9617 (0.9); 6.9429 (0.8);

2.0042 (4.1); 2.0023 (4.2); 1.8560 (16.0); 1.5437 (1.2); -0.0002 (9.5) 2.0042 (4.1); 2.0023 (4.2); 1.8560 (16.0); 1.5437 (1.2); -0.0002 (9.5)

1.71-198: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-198: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7999 (2.7); 7.7979 (2.6); 7.5331 (0.7); 7.5119 (1.0); 7.4907 (0.7); 7.2188 (1.6); 7.1987 (2.2); 7.1784 (1.3); 3.3283 (6.2); 3.1982 (14.0); 2.5229 (1.3); 2.5182 (2.0); 2.5095 (24.8); 2.5050 (52.1); 2.5004 (72.4); 2.4958 (50.1);δ = 7.7999 (2.7); 7.7979 (2.6); 7.5331 (0.7); 7.5119 (1.0); 7.4907 (0.7); 7.2188 (1.6); 7.1987 (2.2); 7.1784 (1.3); 3.3283 (6.2); 3.1982 (14.0); 2.5229 (1.3); 2.5182 (2.0); 2.5095 (24.8); 2.5050 (52.1); 2.5004 (72.4); 2.4958 (50.1);

2.4913 (22.7); 1.9479 (6.5); 1.7364 (16.0); 0.0080 (0.8); -0.0002 (26.4); -0.0086 (0.9) 2.4913 (22.7); 1.9479 (6.5); 1.7364 (16.0); 0.0080 (0.8); -0.0002 (26.4); -0.0086 (0.9)

1.71-199: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-199: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8008 (1.3); 7.7988 (1.4); 7.5112 (0.6); 7.2125 (0.8); 7.1923 (1.1); 7.1722 (0.7); 3.3185 (11.2); 2.7562 (16.0); 2.5230 (1.0); 2.5183 (1.3); 2.5095 (16.0); 2.5050 (33.5); 2.5004 (46.6); 2.4959 (32.2); 2.4913 (14.6); 1.9395 (3.5);δ = 7.8008 (1.3); 7.7988 (1.4); 7.5112 (0.6); 7.2125 (0.8); 7.1923 (1.1); 7.1722 (0.7); 3.3185 (11.2); 2.7562 (16.0); 2.5230 (1.0); 2.5183 (1.3); 2.5095 (16.0); 2.5050 (33.5); 2.5004 (46.6); 2.4959 (32.2); 2.4913 (14.6); 1.9395 (3.5);

1.7367 (8.1); 0.0080 (0.6); -0.0002 (15.8) 1.7367 (8.1); 0.0080 (0.6); -0.0002 (15.8)

1.71-200: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-200: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.9087 (1.6); 7.8680 (3.1); 7.5333 (0.6); 7.5163 (1.0); 7.4966 (0.7); 7.2113 (1.6); 7.1914 (2.6); 7.1714 (1.4); 3.8232 (3.1); 2.5063 (55.0); 2.5023 (74.8); 2.4982 (57.8); 2.3308 (0.7); 1.9370 (8.3); 1.7850 (16.0); -0.0002 (0.8) 1.71-201 : 1 H-NMR(400.0 MHz, CDCI3): δ = 10.9087 (1.6); 7.8680 (3.1); 7.5333 (0.6); 7.5163 (1.0); 7.4966 (0.7); 7.2113 (1.6); 7.1914 (2.6); 7.1714 (1.4); 3.8232 (3.1); 2.5063 (55.0); 2.5023 (74.8); 2.4982 (57.8); 2.3308 (0.7); 1.9370 (8.3); 1.7850 (16.0); -0.0002 (0.8) 1.71-201: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3920 (0.9); 7.3017 (0.6); 7.2606 (25.6); 6.9708 (1.0); 6.9516 (1.1); 6.9310 (0.8); 5.2981 (1.6); 2.0267 (0.5);δ = 7.3920 (0.9); 7.3017 (0.6); 7.2606 (25.6); 6.9708 (1.0); 6.9516 (1.1); 6.9310 (0.8); 5.2981 (1.6); 2.0267 (0.5);

2.0004 (4.8); 1.9986 (5.0); 1.9251 (0.8); 1.8838 (0.8); 1.8790 (1.2); 1.8535 (16.0); -0.0002 (9.0) 2,0004 (4.8); 1.9986 (5.0); 1.9251 (0.8); 1.8838 (0.8); 1.8790 (1.2); 1.8535 (16.0); -0.0002 (9.0)

1.71-202: 1 H-NMR(400.0 MHz, CDCI3):  1.71-202: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5296 (1.7); 7.3468 (0.8); 7.2606 (16.0); 7.0146 (1.1); 6.9955 (1.4); 6.9751 (1.0); 5.2980 (1.7); 2.0245 (5.5);δ = 7.5296 (1.7); 7.3468 (0.8); 7.2606 (16.0); 7.0146 (1.1); 6.9955 (1.4); 6.9751 (1.0); 5.2980 (1.7); 2.0245 (5.5);

2.0229 (5.3); 1.9077 (16.0); 1.4619 (0.8); 1.4437 (10.5); -0.0002 (5.6) 2.0229 (5.3); 1.9077 (16.0); 1.4619 (0.8); 1.4437 (10.5); -0.0002 (5.6)

1.71-203: 1 H-NMR(400.0 MHz, CDCI3):  1.71-203: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5112 (1.6); 7.5093 (1.6); 7.3655 (0.8); 7.2611 (22.0); 7.0351 (1.0); 7.0158 (1.2); 7.0143 (1.0); 6.9952 (0.9);δ = 7.5112 (1.6); 7.5093 (1.6); 7.3655 (0.8); 7.2611 (22.0); 7.0351 (1.0); 7.0158 (1.2); 7.0143 (1.0); 6.9952 (0.9);

5.2985 (7.7); 2.4806 (5.6); 2.0323 (4.4); 2.0304 (4.3); 1.8706 (16.0); 1.5879 (0.5); -0.0002 (8.0) 5.2985 (7.7); 2.4806 (5.6); 2.0323 (4.4); 2.0304 (4.3); 1.8706 (16.0); 1.5879 (0.5); -0.0002 (8.0)

1.71-204: 1 H-NMR(400.0 MHz, CDCI3):  1.71-204: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5148 (1.7); 7.5128 (1.7); 7.3594 (1.2); 7.3545 (0.6); 7.3384 (0.5); 7.2605 (34.2); 7.0285 (1.0); 7.0093 (1.2); 7.0077 (1.1); 6.9886 (0.9); 5.2984 (1.2); 2.7611 (1.7); 2.7447 (0.8); 2.0266 (4.4); 2.0247 (4.4); 1.8758 (16.0); 1.8304δ = 7.5148 (1.7); 7.5128 (1.7); 7.3594 (1.2); 7.3545 (0.6); 7.3384 (0.5); 7.2605 (34.2); 7.0285 (1.0); 7.0093 (1.2); 7.0077 (1.1); 6.9886 (0.9); 5.2984 (1.2); 2.7611 (1.7); 2.7447 (0.8); 2.0266 (4.4); 2.0247 (4.4); 1.8758 (16.0); 1.8304

(0.9); 1.8224 (1.1); 1.8131 (2.4); 1.8041 (1.1); 1.7960 (0.8); 1.5622 (1.6); 1.2568 (0.7); -0.0002 (12.3) (0.9); 1.8224 (1.1); 1.8131 (2.4); 1.8041 (1.1); 1.7960 (0.8); 1.5622 (1.6); 1.2568 (0.7); -0.0002 (12.3)

1.71-205: 1 H-NMR(400.0 MHz, CDCI3):  1.71-205: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5048 (1.8); 7.5029 (1.8); 7.3620 (0.8); 7.3410 (0.6); 7.3250 (0.7); 7.2607 (32.4); 7.0344 (1.0); 7.0153 (1.2); 7.0137 (1.2); 6.9946 (0.9); 2.5995 (1.2); 2.0245 (4.6); 2.0226 (4.8); 1.8654 (16.0); 1.6782 (1.1); 1.6638 (1.6); 1.6494δ = 7.5048 (1.8); 7.5029 (1.8); 7.3620 (0.8); 7.3410 (0.6); 7.3250 (0.7); 7.2607 (32.4); 7.0344 (1.0); 7.0153 (1.2); 7.0137 (1.2); 6.9946 (0.9); 2.5995 (1.2); 2.0245 (4.6); 2.0226 (4.8); 1.8654 (16.0); 1.6782 (1.1); 1.6638 (1.6); 1.6494

(1.2) ; 1.6355 (0.5); 1.5806 (1.5); 1.3769 (0.6); -0.0002 (11.5) (1.2); 1.6355 (0.5); 1.5806 (1.5); 1.3769 (0.6); -0.0002 (11.5)

1.71-206: 1 H-NMR(400.0 MHz, CDCI3):  1.71-206: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6368 (0.8); 7.5109 (1.8); 7.5089 (1.8); 7.3729 (0.8); 7.2606 (38.0); 7.0427 (1.0); 7.0234 (1.3); 7.0028 (0.9); 3.7974 (2.1); 3.7858 (2.4); 3.7740 (2.2); 2.7221 (1.4); 2.7108 (1.8); 2.6996 (1.2); 2.0324 (4.6); 2.0306 (4.7); 1.8715δ = 7.6368 (0.8); 7.5109 (1.8); 7.5089 (1.8); 7.3729 (0.8); 7.2606 (38.0); 7.0427 (1.0); 7.0234 (1.3); 7.0028 (0.9); 3.7974 (2.1); 3.7858 (2.4); 3.7740 (2.2); 2.7221 (1.4); 2.7108 (1.8); 2.6996 (1.2); 2.0324 (4.6); 2.0306 (4.7); 1.8715

(16.0); 1.5586 (9.4); -0.0002 (13.8) (16.0); 1.5586 (9.4); -0.0002 (13.8)

1.71-207: 1 H-NMR(400.0 MHz, CDCI3):  1.71-207: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4648 (1.8); 7.4629 (1.8); 7.2909 (0.8); 7.2699 (0.7); 7.2599 (35.5); 6.9469 (1.1); 6.9280 (1.2); 6.9260 (1.1); 6.9072 (0.9); 5.2984 (1.8); 3.6812 (0.6); 3.6571 (0.7); 3.3820 (0.8); 3.3771 (0.8); 2.9075 (9.6); 2.7327 (0.7); 2.7249δ = 7.4648 (1.8); 7.4629 (1.8); 7.2909 (0.8); 7.2699 (0.7); 7.2599 (35.5); 6.9469 (1.1); 6.9280 (1.2); 6.9260 (1.1); 6.9072 (0.9); 5.2984 (1.8); 3.6812 (0.6); 3.6571 (0.7); 3.3820 (0.8); 3.3771 (0.8); 2.9075 (9.6); 2.7327 (0.7); 2.7249

(0.7); 2.1946 (0.8); 2.1662 (0.7); 1.9857 (5.2); 1.8477 (16.0); 1.5507 (4.0); -0.0002 (16.0) (0.7); 2.1946 (0.8); 2.1662 (0.7); 1.9857 (5.2); 1.8477 (16.0); 1.5507 (4.0); -0.0002 (16.0)

1.71-208: 1 H-NMR(400.0 MHz, CDCI3):  1.71-208: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4212 (2.0); 7.4193 (2.0); 7.2924 (0.8); 7.2714 (0.6); 7.2601 (31.3); 6.9567 (1.1); 6.9375 (1.3); 6.9169 (0.9); 5.2985 (1.1); 3.5288 (0.8); 3.5108 (1.3); 3.4924 (0.8); 2.8018 (0.9); 2.7833 (1.4); 2.7655 (0.8); 2.1434 (9.7); 2.0006δ = 7.4212 (2.0); 7.4193 (2.0); 7.2924 (0.8); 7.2714 (0.6); 7.2601 (31.3); 6.9567 (1.1); 6.9375 (1.3); 6.9169 (0.9); 5.2985 (1.1); 3.5288 (0.8); 3.5108 (1.3); 3.4924 (0.8); 2.8018 (0.9); 2.7833 (1.4); 2.7655 (0.8); 2.1434 (9.7); 2.0006

(5.3) ; 1.9992 (5.4); 1.8450 (16.0); 1.5483 (1.3); -0.0002 (14.5) (5.3); 1.9992 (5.4); 1.8450 (16.0); 1.5483 (1.3); -0.0002 (14.5)

1.71-209: 1 H-NMR(400.0 MHz, CDCI3):  1.71-209: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9252 (1.0); 7.5078 (2.6); 7.3688 (0.7); 7.3478 (1.2); 7.3320 (1.0); 7.3112 (0.7); 7.2622 (36.3); 7.2596 (43.4); 7.0196 (1.3); 7.0005 (2.3); 6.9824 (1.6); 3.4660 (0.6); 3.4482 (1.0); 3.4292 (0.7); 2.0247 (8.2); 1.9808 (2.8); 1.8837 (16.0); 1.8361 (3.2); 1.7877 (1.3); 1.7638 (1.6); 1.7417 (1.6); 1.7215 (1.7); 1.6980 (1.1); 1.6750 (1.0); 1.6255 (0.8); 1.6031 (1.0); 1.5799 (1.0); 1.5438 (1.9); 1.2573 (0.5); -0.0002 (15.2) 1.71-210: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.9252 (1.0); 7.5078 (2.6); 7.3688 (0.7); 7.3478 (1.2); 7.3320 (1.0); 7.3112 (0.7); 7.2622 (36.3); 7.2596 (43.4); 7.0196 (1.3); 7,0005 (2.3); 6.9824 (1.6); 3.4660 (0.6); 3.4482 (1.0); 3.4292 (0.7); 2.0247 (8.2); 1.9808 (2.8); 1.8837 (16.0); 1.8361 (3.2); 1.7877 (1.3); 1.7638 (1.6); 1.7417 (1.6); 1.7215 (1.7); 1.6980 (1.1); 1.6750 (1.0); 1.6255 (0.8); 1.6031 (1.0); 1.5799 (1.0); 1.5438 (1.9); 1.2573 (0.5); -0.0002 (15.2) 1.71-210: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5265 (1.6); 7.5245 (1.6); 7.3445 (0.8); 7.2600 (14.0); 7.0121 (0.9); 6.9930 (1.1); 6.9912 (1.0); 6.9722 (0.8); 5.0734 (0.9); 5.0712 (1.1); 5.0676 (0.6); 5.0465 (0.6); 5.0430 (0.8); 5.0330 (0.5); 3.8113 (0.8); 3.8015 (0.8); 3.7974δ = 7.5265 (1.6); 7.5245 (1.6); 7.3445 (0.8); 7.2600 (14.0); 7.0121 (0.9); 6.9930 (1.1); 6.9912 (1.0); 6.9722 (0.8); 5.0734 (0.9); 5.0712 (1.1); 5.0676 (0.6); 5.0465 (0.6); 5.0430 (0.8); 5.0330 (0.5); 3.8113 (0.8); 3.8015 (0.8); 3.7974

(1.4) ; 3.7933 (0.8); 3.7877 (0.5); 3.7835 (0.8); 2.0268 (4.1); 2.0248 (4.2); 1.8833 (16.0); 1.5566 (2.1); -0.0002 (5.3) 1.71-211 : 1 H-NMR(400.0 MHz, CDCI3): (1.4); 3.7933 (0.8); 3.7877 (0.5); 3.7835 (0.8); 2.0268 (4.1); 2.0248 (4.2); 1.8833 (16.0); 1.5566 (2.1); -0.0002 (5.3) 1.71-211: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5128 (1.6); 7.5108 (1.6); 7.3518 (0.7); 7.2596 (16.7); 7.0220 (1.1); 7.0029 (1.3); 7.0012 (1.2); 6.9823 (0.9); 3.9669 (1.7); 3.9605 (1.8); 3.9538 (1.7); 3.9473 (1.7); 2.1765 (0.9); 2.1701 (1.8); 2.1637 (0.8); 2.0305 (4.3); 2.0286δ = 7.5128 (1.6); 7.5108 (1.6); 7.3518 (0.7); 7.2596 (16.7); 7.0220 (1.1); 7.0029 (1.3); 7.0012 (1.2); 6.9823 (0.9); 3.9669 (1.7); 3.9605 (1.8); 3.9538 (1.7); 3.9473 (1.7); 2.1765 (0.9); 2.1701 (1.8); 2.1637 (0.8); 2.0305 (4.3); 2.0286

(4.2); 1.8721 (16.0); 1.5467 (2.8); -0.0002 (5.9) (4.2); 1.8721 (16.0); 1.5467 (2.8); -0.0002 (5.9)

1.71-212: 1 H-NMR(400.0 MHz, CDCI3):  1.71-212: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5238 (1.6); 7.5218 (1.7); 7.4002 (0.8); 7.2599 (17.2); 7.0606 (1.0); 7.0409 (1.3); 7.0203 (0.9); 2.0524 (4.0);δ = 7.5238 (1.6); 7.5218 (1.7); 7,4002 (0.8); 7.2599 (17.2); 7.0606 (1.0); 7.0409 (1.3); 7.0203 (0.9); 2.0524 (4.0);

2.0502 (4.0); 1.9018 (16.0); -0.0002 (6.6) 2.0502 (4.0); 1.9018 (16.0); -0.0002 (6.6)

1.71-213: 1 H-NMR(400.0 MHz, CDCI3):  1.71-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5147 (1.8); 7.3724 (0.8); 7.3514 (0.5); 7.2596 (16.8); 7.0431 (1.2); 7.0234 (1.5); 7.0033 (1.0); 4.0946 (3.2);δ = 7.5147 (1.8); 7.3724 (0.8); 7.3514 (0.5); 7.2596 (16.8); 7.0431 (1.2); 7.0234 (1.5); 7.0033 (1.0); 4.0946 (3.2);

4.0803 (3.2); 2.0405 (5.0); 1.8793 (16.0); 1.5424 (0.9); -0.0002 (5.8) 4.0803 (3.2); 2.0405 (5.0); 1.8793 (16.0); 1.5424 (0.9); -0.0002 (5.8)

1.71-214: 1 H-NMR(400.0 MHz, CDCI3):  1.71-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3898 (1.7); 7.3880 (1.5); 7.3504 (0.6); 7.3455 (0.6); 7.3343 (0.5); 7.3293 (1.1); 7.3242 (0.6); 7.3136 (0.7); 7.3082 (0.8); 7.2923 (0.6); 7.2595 (60.0); 6.9955 (0.5); 6.9882 (1.1); 6.9693 (1.2); 6.9486 (0.8); 2.0095 (5.1); 2.0078δ = 7.3898 (1.7); 7.3880 (1.5); 7.3504 (0.6); 7.3455 (0.6); 7.3343 (0.5); 7.3293 (1.1); 7.3242 (0.6); 7.3136 (0.7); 7.3082 (0.8); 7.2923 (0.6); 7.2595 (60.0); 6.9955 (0.5); 6.9882 (1.1); 6.9693 (1.2); 6.9486 (0.8); 2.0095 (5.1); 2.0078

(4.6); 1.8904 (0.7); 1.8663 (0.8); 1.8550 (16.0); 1.5369 (2.2); 0.0080 (0.9); -0.0002 (21.5); -0.0085 (0.6) (4.6); 1.8904 (0.7); 1.8663 (0.8); 1.8550 (16.0); 1.5369 (2.2); 0.0080 (0.9); -0.0002 (21.5); -0.0085 (0.6)

1.71-215: 1 H-NMR(400.0 MHz, CDCI3):  1.71-215: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5156 (3.0); 7.5137 (3.0); 7.3937 (0.7); 7.3887 (0.5); 7.3726 (1.3); 7.3564 (0.6); 7.3516 (0.8); 7.2599 (48.0); 7.0424 (1.6); 7.0228 (2.1); 7.0022 (1.5); 4.7689 (1.0); 4.7506 (1.5); 4.7322 (1.0); 2.0411 (7.2); 2.0391 (7.1); 1.8848δ = 7.5156 (3.0); 7.5137 (3.0); 7.3937 (0.7); 7.3887 (0.5); 7.3726 (1.3); 7.3564 (0.6); 7.3516 (0.8); 7.2599 (48.0); 7.0424 (1.6); 7.0228 (2.1); 7.0022 (1.5); 4.7689 (1.0); 4.7506 (1.5); 4.7322 (1.0); 2.0411 (7.2); 2.0391 (7.1); 1.8848

(10.2); 1.8578 (10.3); 1.5424 (16.0); 1.5097 (5.4); 1.4916 (5.4); 0.0080 (0.7); -0.0002 (17.8); -0.0085 (0.7) (10.2); 1.8578 (10.3); 1.5424 (16.0); 1.5097 (5.4); 1.4916 (5.4); 0.0080 (0.7); -0.0002 (17.8); -0.0085 (0.7)

1.71-216: 1 H-NMR(400.0 MHz, CDCI3):  1.71-216: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5215 (1.8); 7.5195 (1.8); 7.3879 (0.5); 7.3718 (0.7); 7.3669 (1.2); 7.3619 (0.5); 7.3458 (0.6); 7.2602 (26.6); 7.0273 (1.0); 7.0077 (1.3); 6.9871 (0.9); 2.0325 (4.6); 2.0305 (4.6); 1.8684 (16.0); 1.8250 (0.6); 1.6700 (3.2); 1.6266δ = 7.5215 (1.8); 7.5195 (1.8); 7.3879 (0.5); 7.3718 (0.7); 7.3669 (1.2); 7.3619 (0.5); 7.3458 (0.6); 7.2602 (26.6); 7.0273 (1.0); 7.0077 (1.3); 6.9871 (0.9); 2.0325 (4.6); 2.0305 (4.6); 1.8684 (16.0); 1.8250 (0.6); 1.6700 (3.2); 1.6266

(14.0); 1.5464 (3.3); -0.0002 (10.0) (14.0); 1.5464 (3.3); -0.0002 (10.0)

1.71-217: 1 H-NMR(400.0 MHz, CDCI3):  1.71-217: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5192 (4.2); 7.5173 (3.9); 7.4726 (0.6); 7.4526 (0.6); 7.3911 (0.9); 7.3860 (0.8); 7.3749 (0.6); 7.3700 (1.8); 7.3650 (0.7); 7.3539 (0.8); 7.3490 (1.1); 7.3329 (0.6); 7.2601 (79.6); 7.0393 (2.4); 7.0197 (2.9); 6.9992 (2.1); 4.6912 (0.8); 4.6725 (1.6); 4.6533 (1.6); 4.6346 (0.8); 3.7775 (0.8); 3.6257 (0.6); 2.0357 (10.0); 2.0338 (10.2); 1.9846 (1.2); 1.8906 (14.5); 1.8790 (0.8); 1.8686 (5.0); 1.8614 (16.0); 1.8505 (6.2); 1.8422 (3.4); 1.8325 (4.5); 1.8247 (6.3); 1.8143δ = 7.5192 (4.2); 7.5173 (3.9); 7.4726 (0.6); 7.4526 (0.6); 7.3911 (0.9); 7.3860 (0.8); 7.3749 (0.6); 7.3700 (1.8); 7.3650 (0.7); 7.3539 (0.8); 7.3490 (1.1); 7.3329 (0.6); 7.2601 (79.6); 7.0393 (2.4); 7.0197 (2.9); 6.9992 (2.1); 4.6912 (0.8); 4.6725 (1.6); 4.6533 (1.6); 4.6346 (0.8); 3.7775 (0.8); 3.6257 (0.6); 2.0357 (10.0); 2.0338 (10.2); 1.9846 (1.2); 1.8906 (14.5); 1.8790 (0.8); 1.8686 (5.0); 1.8614 (16.0); 1.8505 (6.2); 1.8422 (3.4); 1.8325 (4.5); 1.8247 (6.3); 1.8143

(1.5) ; 1.8075 (2.0); 1.7893 (1.5); 1.7732 (1.6); 1.7552 (1.2); 1.7384 (0.7); 1.5420 (1.8); 1.1631 (7.0); 1.1446 (14.2); 1.1392 (6.5); 1.1259 (6.6); 1.1207 (12.2); 1.1022 (5.3); 1.0232 (4.5); 1.0046 (9.4); 0.9860 (4.1); 0.0079 (1.1); -0.0002(1.5); 1.8075 (2.0); 1.7893 (1.5); 1.7732 (1.6); 1.7552 (1.2); 1.7384 (0.7); 1.5420 (1.8); 1.1631 (7.0); 1.1446 (14.2); 1.1392 (6.5); 1.1259 (6.6); 1.1207 (12.2); 1.1022 (5.3); 1.0232 (4.5); 1.0046 (9.4); 0.9860 (4.1); 0.0079 (1.1); -0.0002

(38.9); -0.0085 (1.2) (38.9); -0.0085 (1.2)

1.71-218: 1 H-NMR(400.0 MHz, CDCI3):  1.71-218: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7265 (0.8); 7.7063 (0.8); 7.5457 (4.5); 7.5437 (4.4); 7.4067 (0.6); 7.3906 (1.1); 7.3856 (0.9); 7.3745 (0.7); 7.3695 (2.2); 7.3645 (0.8); 7.3537 (0.9); 7.3484 (1.2); 7.3325 (0.8); 7.3134 (1.3); 7.3114 (1.4); 7.2958 (0.6); 7.2748 (0.6); 7.2600 (75.1); 7.0325 (2.8); 7.0213 (0.5); 7.0131 (3.3); 7.0038 (0.5); 6.9925 (2.5); 6.9673 (0.7); 6.9484 (0.8); 6.9277 (0.6); 5.4208 (4.4); 5.4004 (4.4); 5.3606 (0.5); 5.2983 (4.4); 4.1298 (1.0); 4.1120 (1.0); 2.0427 (9.5); 2.0403 (11.9); 2.0383 (11.6); 2.0242 (0.5); 1.9968 (9.9); 1.9779 (3.1); 1.9761 (3.0); 1.9055 (15.7); 1.8637 (16.0); 1.5830δ = 7.7265 (0.8); 7.7063 (0.8); 7.5457 (4.5); 7.5437 (4.4); 7.4067 (0.6); 7.3906 (1.1); 7.3856 (0.9); 7.3745 (0.7); 7.3695 (2.2); 7.3645 (0.8); 7.3537 (0.9); 7.3484 (1.2); 7.3325 (0.8); 7.3134 (1.3); 7.3114 (1.4); 7.2958 (0.6); 7.2748 (0.6); 7.2600 (75.1); 7.0325 (2.8); 7.0213 (0.5); 7.0131 (3.3); 7.0038 (0.5); 6.9925 (2.5); 6.9673 (0.7); 6.9484 (0.8); 6.9277 (0.6); 5.4208 (4.4); 5.4004 (4.4); 5.3606 (0.5); 5.2983 (4.4); 4.1298 (1.0); 4.1120 (1.0); 2.0427 (9.5); 2.0403 (11.9); 2.0383 (11.6); 2.0242 (0.5); 1.9968 (9.9); 1.9779 (3.1); 1.9761 (3.0); 1.9055 (15.7); 1.8637 (16.0); 1.5830

(1.9); 1.2760 (1.5); 1.2581 (3.2); 1.2402 (1.3); 0.8818 (0.7); 0.0079 (1.2); -0.0002 (37.4); -0.0085 (1.0) (1.9); 1.2760 (1.5); 1.2581 (3.2); 1.2402 (1.3); 0.8818 (0.7); 0.0079 (1.2); -0.0002 (37.4); -0.0085 (1.0)

1.71-219: 1 H-NMR(400.0 MHz, CDCI3):  1.71-219: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5270 (1.7); 7.5251 (1.7); 7.3666 (0.8); 7.2607 (11.8); 7.2103 (0.5); 7.0260 (1.1); 7.0066 (1.3); 6.9861 (1.0); 2.0262 (4.6); 2.0244 (4.6); 1.9063 (1.0); 1.8876 (1.6); 1.8727 (16.0); 1.5765 (7.9); 1.5551 (0.8); 0.9911 (2.0); 0.9725δ = 7.5270 (1.7); 7.5251 (1.7); 7.3666 (0.8); 7.2607 (11.8); 7.2103 (0.5); 7.0260 (1.1); 7.0066 (1.3); 6.9861 (1.0); 2.0262 (4.6); 2.0244 (4.6); 1.9063 (1.0); 1.8876 (1.6); 1.8727 (16.0); 1.5765 (7.9); 1.5551 (0.8); 0.9911 (2.0); 0.9725

(4.2); 0.9538 (1.8); -0.0002 (5.7) (4.2); 0.9538 (1.8); -0.0002 (5.7)

1.71-220: 1 H-NMR(400.0 MHz, CDCI3):  1.71-220: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5303 (3.1); 7.5284 (3.2); 7.3819 (0.8); 7.3767 (0.7); 7.3608 (1.5); 7.3558 (0.5); 7.3448 (0.7); 7.3398 (1.0); 7.3236 (1.1); 7.3198 (0.9); 7.2604 (26.5); 7.0156 (2.0); 6.9964 (2.4); 6.9758 (1.7); 2.0310 (8.4); 2.0292 (8.6); 1.8784 (13.4); 1.8751 (13.5); 1.6622 (16.0); 1.5480 (1.8); 1.1758 (0.6); 1.1720 (0.6); 1.1569 (1.0); 1.1399 (0.6); 0.6295 (0.5); 0.6227 (1.6); 0.6188 (1.6); 0.6133 (3.0); 0.6104 (3.2); 0.6033 (1.4); 0.5968 (2.6); 0.5924 (1.9); 0.5826 (0.6); -0.0002δ = 7.5303 (3.1); 7.5284 (3.2); 7.3819 (0.8); 7.3767 (0.7); 7.3608 (1.5); 7.3558 (0.5); 7.3448 (0.7); 7.3398 (1.0); 7.3236 (1.1); 7.3198 (0.9); 7.2604 (26.5); 7.0156 (2.0); 6.9964 (2.4); 6.9758 (1.7); 2.0310 (8.4); 2.0292 (8.6); 1.8784 (13.4); 1.8751 (13.5); 1.6622 (16.0); 1.5480 (1.8); 1.1758 (0.6); 1.1720 (0.6); 1.1569 (1.0); 1.1399 (0.6); 0.6295 (0.5); 0.6227 (1.6); 0.6188 (1.6); 0.6133 (3.0); 0.6104 (3.2); 0.6033 (1.4); 0.5968 (2.6); 0.5924 (1.9); 0.5826 (0.6); -0.0002

(13-3) (13-3)

1.71-221 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-221: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5244 (4.4); 7.5224 (4.5); 7.4454 (0.7); 7.4238 (0.7); 7.4034 (0.6); 7.3874 (1.1); 7.3823 (0.9); 7.3713 (0.6); 7.3663 (2.1); 7.3612 (0.8); 7.3499 (0.9); 7.3452 (1.3); 7.3292 (0.7); 7.2596 (105.9); 7.0337 (2.7); 7.0144 (3.2); 7.0129 (3.0); 7.0047 (0.5); 6.9937 (2.4); 4.6373 (2.1); 4.6203 (2.2); 4.6157 (2.2); 4.5987 (2.1); 2.0310 (11.4); 2.0290 (11.6); 2.0017 (0.9); 1.9848 (1.6); 1.9680 (1.5); 1.9510 (0.9); 1.8956 (15.7); 1.8657 (16.0); 1.8249 (0.5); 1.5370 (24.0);δ = 7.5244 (4.4); 7.5224 (4.5); 7.4454 (0.7); 7.4238 (0.7); 7.4034 (0.6); 7.3874 (1.1); 7.3823 (0.9); 7.3713 (0.6); 7.3663 (2.1); 7.3612 (0.8); 7.3499 (0.9); 7.3452 (1.3); 7.3292 (0.7); 7.2596 (105.9); 7.0337 (2.7); 7.0144 (3.2); 7.0129 (3.0); 7.0047 (0.5); 6.9937 (2.4); 4.6373 (2.1); 4.6203 (2.2); 4.6157 (2.2); 4.5987 (2.1); 2.0310 (11.4); 2.0290 (11.6); 2.0017 (0.9); 1.9848 (1.6); 1.9680 (1.5); 1.9510 (0.9); 1.8956 (15.7); 1.8657 (16.0); 1.8249 (0.5); 1.5370 (24.0);

1.0191 (9.1); 1.0022 (8.8); 0.9624 (9.5); 0.9455 (9.1); 0.0079 (1.1); -0.0002 (36.6); -0.0085 (1.2) 1.0191 (9.1); 1.0022 (8.8); 0.9624 (9.5); 0.9455 (9.1); 0.0079 (1.1); -0.0002 (36.6); -0.0085 (1.2)

1.71-222: 1 H-NMR(400.0 MHz, CDCI3):  1.71-222: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5117 (2.6); 7.5100 (2.6); 7.3796 (0.6); 7.3745 (0.5); 7.3585 (1.2); 7.3425 (0.5); 7.3375 (0.7); 7.2606 (19.5); 7.0272 (1.6); 7.0076 (2.0); 6.9873 (1.4); 4.9243 (1.1); 4.9047 (1.1); 3.4898 (1.9); 3.4765 (3.1); 3.4615 (1.8); 3.2265 (16.0); 2.0370 (7.0); 2.0353 (6.9); 2.0233 (0.9); 2.0085 (0.8); 1.9925 (0.7); 1.9797 (0.6); 1.9628 (0.6); 1.8837 (9.6);δ = 7.5117 (2.6); 7.5100 (2.6); 7.3796 (0.6); 7.3745 (0.5); 7.3585 (1.2); 7.3425 (0.5); 7.3375 (0.7); 7.2606 (19.5); 7.0272 (1.6); 7.0076 (2.0); 6.9873 (1.4); 4.9243 (1.1); 4.9047 (1.1); 3.4898 (1.9); 3.4765 (3.1); 3.4615 (1.8); 3.2265 (16.0); 2.0370 (7.0); 2.0353 (6.9); 2.0233 (0.9); 2.0085 (0.8); 1.9925 (0.7); 1.9797 (0.6); 1.9628 (0.6); 1.8837 (9.6);

1.8601 (9.7); 1.5584 (3.4); -0.0002 (7.0) 1.8601 (9.7); 1.5584 (3.4); -0.0002 (7.0)

1.71-223: 1 H-NMR(400.0 MHz, CDCI3):  1.71-223: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.5167 (2.5); 7.5148 (2.5); 7.3815 (0.6); 7.3763 (0.6); 7.3604 (1.3); 7.3553 (0.6); 7.3441 (1.2); 7.3395 (1.3); 7.2604 (23.0); 7.0205 (1.5); 7.0012 (1.8); 6.9806 (1.4); 3.6216 (1.8); 3.5983 (2.9); 3.5322 (2.8); 3.5089 (1.7); 3.4693 (0.6); 3.3455 (16.0); 2.0266 (6.6); 2.0248 (6.7); 1.8746 (9.5); 1.8681 (9.6); 1.6186 (10.6); 1.6074 (0.6); -0.0002 (11.6) 1.71-224: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5167 (2.5); 7.5148 (2.5); 7.3815 (0.6); 7.3763 (0.6); 7.3604 (1.3); 7.3553 (0.6); 7.3441 (1.2); 7.3395 (1.3); 7.2604 (23.0); 7.0205 (1.5); 7.0012 (1.8); 6.9806 (1.4); 3.6216 (1.8); 3.5983 (2.9); 3.5322 (2.8); 3.5089 (1.7); 3.4693 (0.6); 3.3455 (16.0); 2.0266 (6.6); 2.0248 (6.7); 1.8746 (9.5); 1.8681 (9.6); 1.6186 (10.6); 1.6074 (0.6); -0.0002 (11.6) 1.71-224: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5269 (4.6); 7.5250 (4.6); 7.5187 (0.7); 7.5031 (0.6); 7.3903 (0.6); 7.3875 (0.6); 7.3692 (1.2); 7.3666 (1.1); 7.3483 (0.8); 7.3456 (0.7); 7.2597 (54.0); 7.0344 (1.9); 7.0153 (2.8); 6.9964 (1.9); 5.6641 (0.8); 4.7390 (0.8); 4.7174δ = 7.5269 (4.6); 7.5250 (4.6); 7.5187 (0.7); 7.5031 (0.6); 7.3903 (0.6); 7.3875 (0.6); 7.3692 (1.2); 7.3666 (1.1); 7.3483 (0.8); 7.3456 (0.7); 7.2597 (54.0); 7.0344 (1.9); 7.0153 (2.8); 6.9964 (1.9); 5.6641 (0.8); 4.7390 (0.8); 4.7174

(1.1) ; 4.7144 (0.9); 4.6984 (0.8); 4.6938 (1.2); 4.6731 (0.8); 2.0806 (0.6); 2.0342 (11.8); 2.0326 (12.2); 2.0099 (0.7); 1.9847 (0.9); 1.9616 (0.6); 1.9543 (0.5); 1.9288 (0.6); 1.8987 (10.1); 1.8962 (9.6); 1.8670 (16.0); 1.8249 (1.7); 1.6916(1.1); 4.7144 (0.9); 4.6984 (0.8); 4.6938 (1.2); 4.6731 (0.8); 2.0806 (0.6); 2.0342 (11.8); 2.0326 (12.2); 2.0099 (0.7); 1.9847 (0.9); 1.9616 (0.6); 1.9543 (0.5); 1.9288 (0.6); 1.8987 (10.1); 1.8962 (9.6); 1.8670 (16.0); 1.8249 (1.7); 1.6916

(0.6); 1.5464 (1.2); 0.0080 (0.8); -0.0002 (26.5); -0.0084 (0.8) (0.6); 1.5464 (1.2); 0.0080 (0.8); -0.0002 (26.5); -0.0084 (0.8)

1.71-225: 1 H-NMR(599.8 MHz, CDCI3):  1.71-225: 1 H-NMR (599.8 MHz, CDCl 3):

δ= 7.5225 (0.5); 7.3678 (6.8); 7.3467 (0.6); 7.3361 (1.2); 7.3327 (1.2); 7.3253 (0.8); 7.3221 (2.4); 7.3189 (0.9); 7.3115 (1.3); 7.3081 (1.4); 7.2975 (0.6); 7.2649 (5.2); 7.0084 (0.4); 6.9866 (0.3); 6.9840 (0.4); 6.9766 (3.5); 6.9699 (0.7); 6.9639 (4.6); 6.9575 (0.8); 6.9506 (3.3); 6.9431 (0.5); 2.4417 (29.5); 2.0320 (1.4); 2.0072 (18.7); 1.8684 (3.9); 1.8524 (49.5); 1.8325 (0.4); 1.7046 (50.0); 1.6849 (0.3); 1.6273 (3.9); 1.6171 (0.8); 1.5934 (0.3); 1.2874 (0.4); 1.2651δ = 7.5225 (0.5); 7.3678 (6.8); 7.3467 (0.6); 7.3361 (1.2); 7.3327 (1.2); 7.3253 (0.8); 7.3221 (2.4); 7.3189 (0.9); 7.3115 (1.3); 7.3081 (1.4); 7.2975 (0.6); 7.2649 (5.2); 7.0084 (0.4); 6.9866 (0.3); 6.9840 (0.4); 6.9766 (3.5); 6.9699 (0.7); 6.9639 (4.6); 6.9575 (0.8); 6.9506 (3.3); 6.9431 (0.5); 2.4417 (29.5); 2.0320 (1.4); 2.0072 (18.7); 1.8684 (3.9); 1.8524 (49.5); 1.8325 (0.4); 1.7046 (50.0); 1.6849 (0.3); 1.6273 (3.9); 1.6171 (0.8); 1.5934 (0.3); 1.2874 (0.4); 1.2651

(0.6); 1.2586 (0.6); 0.8934 (0.5); 0.8819 (1.2); 0.8700 (0.6); -0.0001 (4.6) (0.6); 1.2586 (0.6); 0.8934 (0.5); 0.8819 (1.2); 0.8700 (0.6); -0.0001 (4.6)

1.71-226: 1 H-NMR(400.0 MHz, CDCI3):  1.71-226: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4441 (1.7); 7.4420 (1.7); 7.3595 (0.8); 7.2600 (31.1); 7.2550 (0.8); 7.2534 (0.6); 7.0160 (1.0); 6.9968 (1.2); 6.9952 (1.1); 6.9760 (0.9); 3.7460 (8.2); 2.0310 (4.2); 2.0291 (4.4); 1.9043 (16.0); -0.0002 (15.4); -0.0084 (0.6) 1.71-227: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4441 (1.7); 7.4420 (1.7); 7.3595 (0.8); 7.2600 (31.1); 7.2550 (0.8); 7.2534 (0.6); 7.0160 (1.0); 6.9968 (1.2); 6.9952 (1.1); 6.9760 (0.9); 3.7460 (8.2); 2.0310 (4.2); 2.0291 (4.4); 1.9043 (16.0); -0.0002 (15.4); -0.0084 (0.6) 1.71-227: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5196 (1.8); 7.5185 (1.8); 7.3622 (0.8); 7.2602 (16.1); 7.0321 (1.1); 7.0125 (1.4); 6.9923 (0.9); 5.2983 (0.5); 3.4664 (0.7); 3.4493 (1.6); 3.4340 (1.7); 3.4169 (0.7); 2.5659 (1.6); 2.5487 (3.2); 2.5314 (1.4); 2.0344 (4.8); 2.0329δ = 7.5196 (1.8); 7.5185 (1.8); 7.3622 (0.8); 7.2602 (16.1); 7.0321 (1.1); 7.0125 (1.4); 6.9923 (0.9); 5.2983 (0.5); 3.4664 (0.7); 3.4493 (1.6); 3.4340 (1.7); 3.4169 (0.7); 2.5659 (1.6); 2.5487 (3.2); 2.5314 (1.4); 2.0344 (4.8); 2.0329

(4.7); 1.8707 (16.0); 1.5501 (3.4); -0.0002 (5.8) (4.7); 1.8707 (16.0); 1.5501 (3.4); -0.0002 (5.8)

1.71-228: 1 H-NMR(400.0 MHz, CDCI3):  1.71-228: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4055 (1.5); 7.4040 (1.5); 7.3233 (0.8); 7.3022 (0.5); 7.2605 (21.3); 6.9855 (1.1); 6.9665 (1.2); 6.9647 (1.2);δ = 7.4055 (1.5); 7.4040 (1.5); 7.3233 (0.8); 7.3022 (0.5); 7.2605 (21.3); 6.9855 (1.1); 6.9665 (1.2); 6.9647 (1.2);

6.9458 (0.9); 2.5797 (0.6); 2.0075 (4.9); 2.0060 (5.0); 1.8900 (0.6); 1.8336 (16.0); 1.5545 (1.4); -0.0002 (7.8) 6.9458 (0.9); 2.5797 (0.6); 2.0075 (4.9); 2.0060 (5.0); 1.8900 (0.6); 1.8336 (16.0); 1.5545 (1.4); -0.0002 (7.8)

1.71-229: 1 H-NMR(400.0 MHz, CDCI3):  1.71-229: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5140 (1.7); 7.5120 (1.7); 7.3718 (0.8); 7.3507 (0.5); 7.2595 (39.8); 7.0445 (1.0); 7.0248 (1.3); 7.0042 (0.9);δ = 7.5140 (1.7); 7.5120 (1.7); 7.3718 (0.8); 7.3507 (0.5); 7.2595 (39.8); 7.0445 (1.0); 7.0248 (1.3); 7.0042 (0.9);

2.9278 (0.5); 2.0387 (4.3); 2.0367 (4.3); 1.8529 (16.0); 1.5570 (1.0); -0.0002 (16.2) 2.9278 (0.5); 2.0387 (4.3); 2.0367 (4.3); 1.8529 (16.0); 1.5570 (1.0); -0.0002 (16.2)

1.71-230: 1 H-NMR(400.0 MHz, CDCI3):  1.71-230: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5102 (1.2); 7.5082 (1.2); 7.3550 (0.6); 7.3390 (0.6); 7.3340 (0.6); 7.2601 (14.5); 7.0137 (0.7); 6.9947 (0.8); 6.9928 (0.8); 6.9740 (0.6); 3.7946 (2.0); 3.7711 (2.5); 3.5922 (2.4); 3.5687 (2.0); 3.3372 (16.0); 2.0207 (3.2); 2.0189δ = 7.5102 (1.2); 7.5082 (1.2); 7.3550 (0.6); 7.3390 (0.6); 7.3340 (0.6); 7.2601 (14.5); 7.0137 (0.7); 6.9947 (0.8); 6.9928 (0.8); 6.9740 (0.6); 3.7946 (2.0); 3.7711 (2.5); 3.5922 (2.4); 3.5687 (2.0); 3.3372 (16.0); 2.0207 (3.2); 2.0189

(3.2) ; 1.8720 (11.0); -0.0002 (5.7) (3.2); 1.8720 (11.0); -0.0002 (5.7)

1.71-231 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-231: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5224 (1.9); 7.5202 (2.8); 7.5183 (3.5); 7.5163 (3.0); 7.3706 (0.7); 7.3653 (0.7); 7.3622 (0.9); 7.3496 (1.4); 7.3446 (0.6); 7.3412 (0.6); 7.3338 (0.6); 7.3285 (0.9); 7.2683 (1.0); 7.2668 (1.1); 7.2659 (1.1); 7.2604 (39.2); 7.0203 (1.1); 7.0089 (1.8); 7.0013 (1.4); 6.9994 (1.3); 6.9900 (2.0); 6.9880 (1.9); 6.9803 (1.2); 6.9692 (1.6); 5.2984 (3.2); 4.0194 (0.6); 4.0014 (1.0); 3.9505 (1.0); 3.9318 (1.8); 3.9144 (0.6); 3.8465 (0.7); 3.7985 (0.5); 3.7942 (0.6); 3.7804 (0.6); 3.7769 (0.8); 3.7732 (0.7); 3.7590 (0.7); 3.7550 (1.1); 3.7381 (0.6); 3.6943 (0.5); 3.6914 (0.8); 3.6765 (0.7); 3.6702 (0.6); 2.0549 (0.7); 2.0373 (0.6); 2.0318 (0.6); 2.0201 (10.8); 2.0181 (9.3); 2.0065 (0.6); 1.9071 (0.6); 1.8855 (11.4); 1.8732 (16.0); 1.8666 (7.8); 1.8597 (1.8); 1.8547 (1.3); 1.8475 (1.0); 1.8420 (1.3); 1.8400 (1.2); 1.8319 (0.6); 1.8247 (1.2); 1.8125 (0.6); 1.8060 (0.8); 1.7843 (0.6); 1.6392 (8.7); 1.6048 (15.8); 1.5904 (0.6); 1.5855 (0.6); -0.0002δ = 7.5224 (1.9); 7.5202 (2.8); 7.5183 (3.5); 7.5163 (3.0); 7.3706 (0.7); 7.3653 (0.7); 7.3622 (0.9); 7.3496 (1.4); 7.3446 (0.6); 7.3412 (0.6); 7.3338 (0.6); 7.3285 (0.9); 7.2683 (1.0); 7.2668 (1.1); 7.2659 (1.1); 7.2604 (39.2); 7.0203 (1.1); 7.0089 (1.8); 7.0013 (1.4); 6.9994 (1.3); 6.9900 (2.0); 6.9880 (1.9); 6.9803 (1.2); 6.9692 (1.6); 5.2984 (3.2); 4.0194 (0.6); 4.0014 (1.0); 3.9505 (1.0); 3.9318 (1.8); 3.9144 (0.6); 3.8465 (0.7); 3.7985 (0.5); 3.7942 (0.6); 3.7804 (0.6); 3.7769 (0.8); 3.7732 (0.7); 3.7590 (0.7); 3.7550 (1.1); 3.7381 (0.6); 3.6943 (0.5); 3.6914 (0.8); 3.6765 (0.7); 3.6702 (0.6); 2.0549 (0.7); 2.0373 (0.6); 2.0318 (0.6); 2.0201 (10.8); 2.0181 (9.3); 2.0065 (0.6); 1.9071 (0.6); 1.8855 (11.4); 1.8732 (16.0); 1.8666 (7.8); 1.8597 (1.8); 1.8547 (1.3); 1.8475 (1.0); 1.8420 (1.3); 1.8400 (1.2); 1.8319 (0.6); 1.8247 (1.2); 1.8125 (0.6); 1.8060 (0.8); 1.7843 (0.6); 1.6392 (8.7); 1.6048 (15.8); 1.5904 (0.6); 1.5855 (0.6); -0.0002

(15-5) (15-5)

1.71-232: 1 H-NMR(400.0 MHz, CDCI3):  1.71-232: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5281 (2.8); 7.5261 (2.9); 7.5240 (1.8); 7.5218 (2.6); 7.5197 (2.7); 7.3937 (0.9); 7.3908 (1.0); 7.3882 (1.1); 7.3854 (1.2); 7.3778 (1.0); 7.3727 (1.6); 7.3698 (1.4); 7.3648 (0.5); 7.3562 (0.7); 7.3517 (1.0); 7.3488 (0.8); 7.3007 (0.8); 7.2602 (70.2); 7.0326 (1.6); 7.0304 (2.3); 7.0111 (3.2); 6.9960 (0.9); 6.9925 (1.9); 6.9902 (1.6); 3.8878 (0.9); 3.8761 (0.8); 3.8662 (1.8); 3.8547 (1.6); 3.8448 (1.0); 3.8332 (0.9); 3.7769 (0.7); 3.7576 (0.8); 3.7531 (1.3); 3.7385δ = 7.5281 (2.8); 7.5261 (2.9); 7.5240 (1.8); 7.5218 (2.6); 7.5197 (2.7); 7.3937 (0.9); 7.3908 (1.0); 7.3882 (1.1); 7.3854 (1.2); 7.3778 (1.0); 7.3727 (1.6); 7.3698 (1.4); 7.3648 (0.5); 7.3562 (0.7); 7.3517 (1.0); 7.3488 (0.8); 7.3007 (0.8); 7.2602 (70.2); 7.0326 (1.6); 7.0304 (2.3); 7.0111 (3.2); 6.9960 (0.9); 6.9925 (1.9); 6.9902 (1.6); 3.8878 (0.9); 3.8761 (0.8); 3.8662 (1.8); 3.8547 (1.6); 3.8448 (1.0); 3.8332 (0.9); 3.7769 (0.7); 3.7576 (0.8); 3.7531 (1.3); 3.7385

(2.0) ; 3.7350 (2.6); 3.7203 (3.2); 3.7146 (0.8); 3.6994 (1.4); 3.6953 (1.6); 3.6907 (1.3); 3.6756 (2.0); 3.6668 (0.7); 3.6586 (0.5); 3.6516 (0.8); 2.8739 (0.5); 2.8678 (0.9); 2.8508 (0.9); 2.2048 (2.0); 2.0435 (0.6); 2.0289 (12.7); 2.0270 (12.9); 2.0138 (0.6); 2.0105 (0.5); 2.0017 (0.7); 1.9903 (0.6); 1.8746 (10.2); 1.8674 (16.0); 1.8640 (11.0); 1.8506 (0.5); 1.8306 (0.5); 1.8136 (0.6); 1.8011 (0.7); 1.7820 (0.6); 1.6493 (2.0); 1.6022 (10.8); 1.5875 (1.6); 1.5680 (13.6);(2.0); 3.7350 (2.6); 3.7203 (3.2); 3.7146 (0.8); 3.6994 (1.4); 3.6953 (1.6); 3.6907 (1.3); 3.6756 (2.0); 3.6668 (0.7); 3.6586 (0.5); 3.6516 (0.8); 2.8739 (0.5); 2.8678 (0.9); 2.8508 (0.9); 2.2048 (2.0); 2.0435 (0.6); 2.0289 (12.7); 2.0270 (12.9); 2.0138 (0.6); 2.0105 (0.5); 2.0017 (0.7); 1.9903 (0.6); 1.8746 (10.2); 1.8674 (16.0); 1.8640 (11.0); 1.8506 (0.5); 1.8306 (0.5); 1.8136 (0.6); 1.8011 (0.7); 1.7820 (0.6); 1.6493 (2.0); 1.6022 (10.8); 1.5875 (1.6); 1.5680 (13.6);

0.0080 (0.8); -0.0002 (30.0); -0.0085 (0.9) 0.0080 (0.8); -0.0002 (30.0); -0.0085 (0.9)

1.71-233: 1 H-NMR(400.0 MHz, CDCI3):  1.71-233: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5322 (0.6); 7.5268 (1.9); 7.5248 (1.9); 7.5138 (0.5); 7.5118 (0.5); 7.3730 (0.9); 7.3577 (0.5); 7.3519 (0.6); 7.3215 (0.9); 7.2608 (21.1); 7.0326 (1.1); 7.0133 (1.6); 7.0032 (0.5); 7.0017 (0.5); 6.9995 (0.5); 6.9927 (1.3); 5.2985 (1.7); 3.4086 (0.8); 3.3339 (0.8); 3.3170 (13.1); 3.3135 (1.6); 3.2858 (3.6); 2.3855 (0.6); 2.0251 (6.7); 1.8900 (5.9); 1.8712 (16.0); 1.8663 (5.8); 1.8249 (0.6); 1.8185 (0.7); 1.8084 (0.8); 1.7075 (1.0); 1.6928 (1.0); 1.6823 (0.9); 1.6710δ = 7.5322 (0.6); 7.5268 (1.9); 7.5248 (1.9); 7.5138 (0.5); 7.5118 (0.5); 7.3730 (0.9); 7.3577 (0.5); 7.3519 (0.6); 7.3215 (0.9); 7.2608 (21.1); 7.0326 (1.1); 7.0133 (1.6); 7.0032 (0.5); 7.0017 (0.5); 6.9995 (0.5); 6.9927 (1.3); 5.2985 (1.7); 3.4086 (0.8); 3.3339 (0.8); 3.3170 (13.1); 3.3135 (1.6); 3.2858 (3.6); 2.3855 (0.6); 2.0251 (6.7); 1.8900 (5.9); 1.8712 (16.0); 1.8663 (5.8); 1.8249 (0.6); 1.8185 (0.7); 1.8084 (0.8); 1.7075 (1.0); 1.6928 (1.0); 1.6823 (0.9); 1.6710

(0.7); -0.0002 (9.1) (0.7); -0.0002 (9.1)

1.71-234: 1 H-NMR(400.0 MHz, CDCI3):  1.71-234: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5369 (2.3); 7.3388 (1.4); 7.3301 (0.9); 7.3139 (1.0); 7.3086 (1.1); 7.2979 (0.6); 7.2928 (1.5); 7.2875 (0.9); 7.2767 (0.9); 7.2717 (1.2); 7.2589 (35.9); 7.2449 (1.3); 7.2316 (2.8); 7.2216 (1.7); 7.2131 (2.9); 7.2085 (1.7); 7.1966δ = 7.5369 (2.3); 7.3388 (1.4); 7.3301 (0.9); 7.3139 (1.0); 7.3086 (1.1); 7.2979 (0.6); 7.2928 (1.5); 7.2875 (0.9); 7.2767 (0.9); 7.2717 (1.2); 7.2589 (35.9); 7.2449 (1.3); 7.2316 (2.8); 7.2216 (1.7); 7.2131 (2.9); 7.2085 (1.7); 7.1966

(1.1) ; 6.9585 (1.9); 6.9394 (2.3); 6.9189 (1.7); 5.2971 (6.4); 3.4926 (0.5); 3.4595 (1.2); 3.4159 (1.4); 3.3829 (0.6);(1.1); 6.9585 (1.9); 6.9394 (2.3); 6.9189 (1.7); 5.2971 (6.4); 3.4926 (0.5); 3.4595 (1.2); 3.4159 (1.4); 3.3829 (0.6);

2.0501 (9.6); 2.0485 (9.6); 1.8659 (16.0); 1.5542 (0.8); -0.0002 (14.8) 2.0501 (9.6); 2.0485 (9.6); 1.8659 (16.0); 1.5542 (0.8); -0.0002 (14.8)

1.71-235: 1 H-NMR(400.0 MHz, CDCI3):  1.71-235: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3748 (0.6); 7.3667 (5.9); 7.3647 (5.8); 7.3589 (1.2); 7.3539 (1.0); 7.3429 (0.6); 7.3378 (2.0); 7.3329 (0.7); 7.3219 (1.0); 7.3169 (1.2); 7.3010 (0.6); 7.2606 (55.8); 6.9984 (2.8); 6.9883 (0.6); 6.9796 (3.4); 6.9695 (0.6); 6.9591 (2.4); 5.2984 (2.5); 2.0033 (16.0); 2.0015 (15.9); 1.9111 (0.5); 1.8851 (5.3); 1.8631 (2.1); 1.8314 (9.2); 1.5539 (1.3); 1.2562 (0.5); 1.1606 (0.5); 1.0764 (0.5); 1.0583 (0.7); 0.0080 (0.6); -0.0002 (22.7); -0.0085 (0.6) 1.71-236: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3748 (0.6); 7.3667 (5.9); 7.3647 (5.8); 7.3589 (1.2); 7.3539 (1.0); 7.3429 (0.6); 7.3378 (2.0); 7.3329 (0.7); 7.3219 (1.0); 7.3169 (1.2); 7.3010 (0.6); 7.2606 (55.8); 6.9984 (2.8); 6.9883 (0.6); 6.9796 (3.4); 6.9695 (0.6); 6.9591 (2.4); 5.2984 (2.5); 2.0033 (16.0); 2.0015 (15.9); 1.9111 (0.5); 1.8851 (5.3); 1.8631 (2.1); 1.8314 (9.2); 1.5539 (1.3); 1.2562 (0.5); 1.1606 (0.5); 1.0764 (0.5); 1.0583 (0.7); 0.0080 (0.6); -0.0002 (22.7); -0.0085 (0.6) 1.71-236: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3757 (0.6); 7.3677 (6.0); 7.3657 (6.1); 7.3598 (1.2); 7.3548 (1.0); 7.3439 (0.8); 7.3388 (1.9); 7.3337 (0.7); 7.3228 (1.0); 7.3177 (1.2); 7.3018 (0.5); 7.2605 (74.2); 6.9993 (2.8); 6.9892 (0.6); 6.9805 (3.4); 6.9705 (0.6); 6.9599 (2.5); 3.4164 (1.3); 3.3512 (0.9); 3.3329 (0.9); 3.3287 (1.2); 3.3176 (1.4); 3.2948 (4.8); 3.2688 (1.1); 3.2544 (0.8); 3.2476 (0.7); 3.2374 (0.5); 3.2303 (2.1); 2.0285 (0.8); 2.0265 (0.8); 2.0018 (15.8); 2.0001 (16.0); 1.8905 (5.0); 1.8792 (2.1); 1.8625 (3.0); 1.8584 (1.1); 1.8220 (8.2); 1.5715 (0.6); 1.5544 (1.3); 0.0080 (0.9); -0.0002 (31.4); -0.0085 (1.0) 1.71-237: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 7.3757 (0.6); 7.3677 (6.0); 7.3657 (6.1); 7.3598 (1.2); 7.3548 (1.0); 7.3439 (0.8); 7.3388 (1.9); 7.3337 (0.7); 7.3228 (1.0); 7.3177 (1.2); 7.3018 (0.5); 7.2605 (74.2); 6.9993 (2.8); 6.9892 (0.6); 6.9805 (3.4); 6.9705 (0.6); 6.9599 (2.5); 3.4164 (1.3); 3.3512 (0.9); 3.3329 (0.9); 3.3287 (1.2); 3.3176 (1.4); 3.2948 (4.8); 3.2688 (1.1); 3.2544 (0.8); 3.2476 (0.7); 3.2374 (0.5); 3.2303 (2.1); 2.0285 (0.8); 2.0265 (0.8); 2.0018 (15.8); 2,0001 (16.0); 1.8905 (5.0); 1.8792 (2.1); 1.8625 (3.0); 1.8584 (1.1); 1.8220 (8.2); 1.5715 (0.6); 1.5544 (1.3); 0.0080 (0.9); -0.0002 (31.4); -0.0085 (1.0) 1.71-237: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.0562 (1.3); 10.0480 (1.4); 9.4034 (1.6); 9.3952 (1.6); 7.8013 (2.9); 7.7995 (2.9); 7.5232 (0.6); 7.5183 (0.5); 7.5021 (1.2); 7.4859 (0.5); 7.4810 (0.7); 7.2018 (1.7); 7.1818 (2.5); 7.1616 (1.5); 3.3503 (3.9); 2.8578 (13.2); 2.6695 (0.5); 2.5228 (2.6); 2.5181 (3.6); 2.5094 (32.1); 2.5049 (65.0); 2.5004 (88.0); 2.4958 (60.8); 2.4913 (27.4); 1.9248δ = 10.0562 (1.3); 10.0480 (1.4); 9.4034 (1.6); 9.3952 (1.6); 7.8013 (2.9); 7.7995 (2.9); 7.5232 (0.6); 7.5183 (0.5); 7.5021 (1.2); 7.4859 (0.5); 7.4810 (0.7); 7.2018 (1.7); 7.1818 (2.5); 7.1616 (1.5); 3.3503 (3.9); 2.8578 (13.2); 2.6695 (0.5); 2.5228 (2.6); 2.5181 (3.6); 2.5094 (32.1); 2.5049 (65.0); 2.5004 (88.0); 2.4958 (60.8); 2.4913 (27.4); 1.9248

(7.5); 1.7490 (16.0); 1.7340 (1.3); 1.2356 (1.1); 0.0080 (1.1); -0.0002 (29.6); -0.0086 (0.8) (7.5); 1.7490 (16.0); 1.7340 (1.3); 1.2356 (1.1); 0.0080 (1.1); -0.0002 (29.6); -0.0086 (0.8)

1.71-238: 1 H-NMR(400.0 MHz, CDCI3):  1.71-238: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5229 (1.8); 7.5209 (1.8); 7.3678 (0.8); 7.3467 (0.5); 7.2599 (32.4); 7.1958 (0.5); 7.0291 (1.0); 7.0098 (1.2); 7.0083 (1.2); 6.9890 (0.9); 2.2224 (0.5); 2.0248 (4.6); 2.0228 (4.6); 1.9256 (0.6); 1.9019 (0.7); 1.8895 (0.6); 1.8694δ = 7.5229 (1.8); 7.5209 (1.8); 7.3678 (0.8); 7.3467 (0.5); 7.2599 (32.4); 7.1958 (0.5); 7.0291 (1.0); 7.0098 (1.2); 7.0083 (1.2); 6.9890 (0.9); 2.2224 (0.5); 2.0248 (4.6); 2.0228 (4.6); 1.9256 (0.6); 1.9019 (0.7); 1.8895 (0.6); 1.8694

(16.0) ; 1.6449 (0.8); 1.6373 (0.8); 1.6222 (0.7); 1.6095 (0.7); 1.6021 (0.7); 1.5945 (0.6); 1.5812 (0.6); 1.5743 (0.6);(16.0); 1.6449 (0.8); 1.6373 (0.8); 1.6222 (0.7); 1.6095 (0.7); 1.6021 (0.7); 1.5945 (0.6); 1.5812 (0.6); 1.5743 (0.6);

1.5644 (0.7); 1.5518 (1.3); 1.5341 (0.6); 1.5258 (0.5); -0.0002 (13.6) 1.5644 (0.7); 1.5518 (1.3); 1.5341 (0.6); 1.5258 (0.5); -0.0002 (13.6)

1.71-239: 1 H-NMR(400.0 MHz, CDCI3):  1.71-239: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3609 (1.3); 7.3450 (2.0); 7.3400 (1.5); 7.3291 (0.9); 7.3240 (2.5); 7.3189 (0.9); 7.3080 (1.1); 7.3029 (1.5); 7.2871 (0.8); 7.2608 (48.1); 6.9965 (0.6); 6.9851 (3.1); 6.9751 (0.6); 6.9663 (3.5); 6.9643 (3.3); 6.9558 (0.6); 6.9456 (2.7); 5.2982 (2.1); 3.5843 (0.6); 3.5522 (0.6); 3.0799 (0.7); 3.0477 (0.5); 1.9947 (15.8); 1.9931 (16.0); 1.8446 (8.4);δ = 7.3609 (1.3); 7.3450 (2.0); 7.3400 (1.5); 7.3291 (0.9); 7.3240 (2.5); 7.3189 (0.9); 7.3080 (1.1); 7.3029 (1.5); 7.2871 (0.8); 7.2608 (48.1); 6.9965 (0.6); 6.9851 (3.1); 6.9751 (0.6); 6.9663 (3.5); 6.9643 (3.3); 6.9558 (0.6); 6.9456 (2.7); 5.2982 (2.1); 3.5843 (0.6); 3.5522 (0.6); 3.0799 (0.7); 3.0477 (0.5); 1.9947 (15.8); 1.9931 (16.0); 1.8446 (8.4);

1.8125 (2.8); 1.5847 (0.6); 1.2585 (1.4); 0.0080 (0.6); -0.0002 (20.1); -0.0085 (0.6) 1.8125 (2.8); 1.5847 (0.6); 1.2585 (1.4); 0.0080 (0.6); -0.0002 (20.1); -0.0085 (0.6)

1.71-240: 1 H-NMR(400.0 MHz, CDCI3):  1.71-240: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5192 (1.2); 7.4262 (1.4); 7.4104 (0.6); 7.3993 (2.7); 7.3703 (0.7); 7.3543 (1.3); 7.3494 (1.3); 7.3382 (0.9); 7.3333 (2.6); 7.3283 (1.1); 7.3171 (1.4); 7.3123 (1.8); 7.3102 (1.8); 7.2962 (1.1); 7.2732 (1.2); 7.2684 (2.1); 7.2603 (200.3); 6.9963 (1.5); 6.9877 (3.7); 6.9775 (0.8); 6.9688 (4.5); 6.9670 (4.3); 6.9481 (3.2); 5.8987 (0.6); 5.8618 (0.9); 5.2986 (8.1); 4.1308 (1.4); 4.1130 (1.4); 3.6703 (0.8); 3.6526 (0.9); 3.6369 (2.1); 3.6181 (1.7); 3.6000 (0.7); 3.5422 (0.8); 3.5112 (0.5); 3.3439 (0.6); 3.3191 (0.8); 3.2182 (0.9); 3.1841 (1.3); 3.1595 (1.7); 3.0848 (1.7); 3.0608 (1.1); 2.7786 (0.6); 2.7367 (0.9); 2.7095 (2.1); 2.6821 (2.3); 2.6547 (1.1); 2.4035 (0.6); 2.3606 (1.1); 2.2980 (1.1); 2.2751 (1.1); 2.2553 (0.6); 2.2325 (2.3); 2.1697 (2.2); 2.1271 (1.0); 2.0775 (0.6); 2.0439 (6.9); 1.9918 (10.7); 1.8695 (1.1); 1.8364 (11.0); 1.8232 (16.0); 1.2766 (2.1); 1.2587 (4.4); 1.2409 (2.0); 0.0497 (0.5); 0.0080 (3.1); -0.0002 (86.3); -δ = 7.5192 (1.2); 7.4262 (1.4); 7.4104 (0.6); 7.3993 (2.7); 7.3703 (0.7); 7.3543 (1.3); 7.3494 (1.3); 7.3382 (0.9); 7.3333 (2.6); 7.3283 (1.1); 7.3171 (1.4); 7.3123 (1.8); 7.3102 (1.8); 7.2962 (1.1); 7.2732 (1.2); 7.2684 (2.1); 7.2603 (200.3); 6.9963 (1.5); 6,987 (3.7); 6.9775 (0.8); 6.9688 (4.5); 6.9670 (4.3); 6.9481 (3.2); 5.8987 (0.6); 5.8618 (0.9); 5.2986 (8.1); 4.1308 (1.4); 4.1130 (1.4); 3.6703 (0.8); 3.6526 (0.9); 3.6369 (2.1); 3.6181 (1.7); 3.6000 (0.7); 3.5422 (0.8); 3.5112 (0.5); 3.3439 (0.6); 3,3191 (0.8); 3.2182 (0.9); 3.1841 (1.3); 3.1595 (1.7); 3.0848 (1.7); 3.0608 (1.1); 2.7786 (0.6); 2.7367 (0.9); 2.7095 (2.1); 2.6821 (2.3); 2.6547 (1.1); 2.4035 (0.6); 2.3606 (1.1); 2.2980 (1.1); 2.2751 (1.1); 2.2553 (0.6); 2.2325 (2.3); 2.1697 (2.2); 2.1271 (1.0); 2.0775 (0.6); 2.0439 (6.9); 1.9918 (10.7); 1.8695 (1.1); 1.8364 (11.0); 1.8232 (16.0); 1.2766 (2.1); 1.2587 (4.4); 1.2409 (2.0); 0.0497 (0.5); 0.0080 (3.1); -0.0002 (86.3); -

0.0085 (2.3) 0.0085 (2.3)

1.71-241 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-241: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.4418 (1.8); 7.6572 (1.7); 7.6562 (1.7); 7.5691 (1.8); 7.5672 (1.8); 7.4131 (0.8); 7.3920 (0.5); 7.2601 (25.1); 7.0982 (1.1); 7.0782 (1.5); 7.0578 (1.0); 5.2982 (1.1); 2.0638 (4.4); 2.0617 (4.6); 1.9629 (16.0); 1.8902 (0.6); -0.0002δ = 8.4418 (1.8); 7.6572 (1.7); 7.6562 (1.7); 7.5691 (1.8); 7.5672 (1.8); 7.4131 (0.8); 7.3920 (0.5); 7.2601 (25.1); 7.0982 (1.1); 7.0.782 (1.5); 7.0578 (1.0); 5.2982 (1.1); 2.0638 (4.4); 2.0617 (4.6); 1.9629 (16.0); 1.8902 (0.6); -0.0002

(10-2) (10-2)

1.71-242: 1 H-NMR(400.0 MHz, CDCI3):  1.71-242: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5370 (3.2); 7.5350 (3.2); 7.5196 (1.4); 7.5178 (1.2); 7.3765 (0.8); 7.3710 (0.7); 7.3605 (0.5); 7.3554 (1.5); 7.3503 (0.6); 7.3475 (0.6); 7.3392 (0.7); 7.3343 (0.9); 7.2604 (40.7); 7.2034 (1.0); 7.0159 (2.3); 7.0099 (1.2); 6.9967 (2.5); 6.9950 (2.3); 6.9760 (1.7); 6.9702 (0.7); 5.2984 (2.6); 3.4917 (0.6); 3.2455 (12.5); 3.2025 (6.6); 2.0276 (8.5); 2.0256 (9.3); 2.0235 (6.3); 2.0212 (3.9); 1.8846 (13.0); 1.8784 (16.0); 1.6085 (0.6); 1.6007 (0.8); 1.5925 (0.7); 1.5844 (0.8); 1.5750 (1.0); 1.5671 (1.3); 1.5577 (1.4); 1.5507 (1.4); 1.5441 (1.2); 1.5345 (1.4); 1.5247 (1.1); 1.5120 (0.6);δ = 7.5370 (3.2); 7.5350 (3.2); 7.5196 (1.4); 7.5178 (1.2); 7.3765 (0.8); 7.3710 (0.7); 7.3605 (0.5); 7.3554 (1.5); 7.3503 (0.6); 7.3475 (0.6); 7.3392 (0.7); 7.3343 (0.9); 7.2604 (40.7); 7.2034 (1.0); 7.0159 (2.3); 7.0099 (1.2); 6.9967 (2.5); 6.9950 (2.3); 6.9760 (1.7); 6.9702 (0.7); 5.2984 (2.6); 3.4917 (0.6); 3.2455 (12.5); 3.2025 (6.6); 2.0276 (8.5); 2.0256 (9.3); 2.0235 (6.3); 2.0212 (3.9); 1.8846 (13.0); 1.8784 (16.0); 1.6085 (0.6); 1.6007 (0.8); 1.5925 (0.7); 1.5844 (0.8); 1.5750 (1.0); 1.5671 (1.3); 1.5577 (1.4); 1.5507 (1.4); 1.5441 (1.2); 1.5345 (1.4); 1.5247 (1.1); 1.5120 (0.6);

1.5000 (0.8); 1.4675 (0.7); 0.0079 (0.6); -0.0002 (17.5); -0.0085 (0.5) 1.5000 (0.8); 1.4675 (0.7); 0.0079 (0.6); -0.0002 (17.5); -0.0085 (0.5)

1.71-243: 1 H-NMR(400.0 MHz, CDCI3):  1.71-243: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5034 (1.8); 7.5014 (1.8); 7.3714 (0.8); 7.3503 (0.5); 7.2604 (19.0); 7.0451 (1.1); 7.0255 (1.3); 7.0048 (0.9); 3.9357 (1.4); 3.9216 (2.1); 3.9072 (1.4); 2.5893 (1.4); 2.5711 (3.0); 2.5530 (1.6); 2.0360 (4.5); 2.0340 (4.6); 1.9581 (0.7); 1.9545 (0.8); 1.9440 (0.5); 1.9401 (1.2); 1.9365 (0.5); 1.9259 (0.8); 1.9231 (0.6); 1.8771 (16.0); -0.0002 (7.8) 1.71-244: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5034 (1.8); 7.5014 (1.8); 7.3714 (0.8); 7.3503 (0.5); 7.2604 (19.0); 7.0451 (1.1); 7.0255 (1.3); 7.0048 (0.9); 3.9357 (1.4); 3.9216 (2.1); 3.9072 (1.4); 2.5893 (1.4); 2.5711 (3.0); 2.5530 (1.6); 2.0360 (4.5); 2.0340 (4.6); 1.9581 (0.7); 1.9545 (0.8); 1.9440 (0.5); 1.9401 (1.2); 1.9365 (0.5); 1.9259 (0.8); 1.9231 (0.6); 1.8771 (16.0); -0.0002 (7.8) 1.71-244: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3856 (6.1); 7.3836 (6.1); 7.3634 (0.7); 7.3475 (1.4); 7.3425 (1.1); 7.3316 (0.9); 7.3265 (2.6); 7.3213 (1.0); 7.3102 (1.2); 7.3054 (1.6); 7.2896 (0.9); 7.2601 (63.6); 6.9963 (0.7); 6.9867 (3.3); 6.9802 (0.6); 6.9764 (0.6); 6.9678 (3.7); 6.9658 (3.5); 6.9575 (0.6); 6.9530 (0.5); 6.9469 (2.8); 2.5492 (1.1); 2.0082 (15.4); 2.0064 (15.8); 1.8965 (0.7); 1.8910 (0.7); 1.8663 (16.0); 1.8433 (1.6); 1.8235 (9.5); 1.5546 (1.3); 1.0044 (1.8); 0.9951 (2.1); 0.0079 (0.8); -0.0002δ = 7.3856 (6.1); 7.3836 (6.1); 7.3634 (0.7); 7.3475 (1.4); 7.3425 (1.1); 7.3316 (0.9); 7.3265 (2.6); 7.3213 (1.0); 7.3102 (1.2); 7.3054 (1.6); 7.2896 (0.9); 7.2601 (63.6); 6.9963 (0.7); 6.9867 (3.3); 6.9802 (0.6); 6.9764 (0.6); 6.9678 (3.7); 6.9658 (3.5); 6.9575 (0.6); 6.9530 (0.5); 6.9469 (2.8); 2.5492 (1.1); 2.0082 (15.4); 2.0064 (15.8); 1.8965 (0.7); 1.8910 (0.7); 1.8663 (16.0); 1.8433 (1.6); 1.8235 (9.5); 1.5546 (1.3); 1.0044 (1.8); 0.9951 (2.1); 0.0079 (0.8); -0.0002

(27.1) ; -0.0085 (0.8) (27.1); -0.0085 (0.8)

1.71-245: 1 H-NMR(400.0 MHz, CDCI3):  1.71-245: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3930 (3.2); 7.3911 (3.3); 7.3339 (0.5); 7.3291 (0.6); 7.3131 (1.1); 7.2972 (0.6); 7.2924 (0.7); 7.2765 (0.5); 7.2758 (0.5); 7.2750 (0.5); 7.2694 (0.5); 7.2686 (0.6); 7.2678 (0.6); 7.2669 (0.7); 7.2661 (0.8); 7.2653 (1.0); 7.2612 (35.3); 7.2548 (0.7); 7.2540 (0.6); 6.9745 (1.3); 6.9558 (1.9); 6.9369 (1.2); 3.6541 (0.6); 3.3161 (4.3); 3.3021 (0.8); 3.2942 (1.0); 3.2812 (1.1); 3.2561 (5.3); 3.1794 (0.5); 3.1632 (0.5); 3.1137 (0.5); 2.3161 (0.5); 1.9943 (10.4); 1.9926 (10.3); 1.8607 (0.7); 1.8449 (0.8); 1.8202 (16.0); 1.5992 (1.4); 1.5477 (0.5); 0.0080 (0.5); -0.0002 (15.9); -0.0085δ = 7.3930 (3.2); 7.3911 (3.3); 7.3339 (0.5); 7.3291 (0.6); 7.3131 (1.1); 7.2972 (0.6); 7.2924 (0.7); 7.2765 (0.5); 7.2758 (0.5); 7.2750 (0.5); 7.2694 (0.5); 7.2686 (0.6); 7.2678 (0.6); 7.2669 (0.7); 7.2661 (0.8); 7.2653 (1.0); 7.2612 (35.3); 7.2548 (0.7); 7.2540 (0.6); 6.9745 (1.3); 6.9558 (1.9); 6.9369 (1.2); 3.6541 (0.6); 3.3161 (4.3); 3.3021 (0.8); 3.2942 (1.0); 3.2812 (1.1); 3.2561 (5.3); 3.1794 (0.5); 3.1632 (0.5); 3.1137 (0.5); 2.3161 (0.5); 1.9943 (10.4); 1.9926 (10.3); 1.8607 (0.7); 1.8449 (0.8); 1.8202 (16.0); 1.5992 (1.4); 1.5477 (0.5); 0.0080 (0.5); -0.0002 (15.9); -0.0085

(0-6) (0-6)

1.71-246: 1 H-NMR(400.0 MHz, CDCI3):  1.71-246: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4268 (3.0); 7.3506 (0.7); 7.3341 (1.0); 7.3142 (0.8); 7.2690 (0.5); 7.2682 (0.6); 7.2674 (0.7); 7.2609 (53.8); 6.9968 (0.7); 6.9890 (1.4); 6.9699 (2.3); 6.9514 (1.3); 5.2985 (4.5); 3.7632 (0.8); 3.7434 (1.1); 3.1811 (0.7); 3.1527 (0.8); 2.4501 (0.8); 2.4211 (0.7); 2.2516 (0.7); 2.2357 (0.8); 2.2200 (0.8); 2.0025 (16.0); 2.0016 (16.0); 1.8683 (4.6); 1.8479 (3.2); 1.8128 (7.1); 1.7587 (0.6); 1.5736 (2.9); 1.4451 (2.4); 1.3083 (4.5); 0.0080 (0.7); -0.0002 (23.5); - 0.0085 (0.8) 1.71-247: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4268 (3.0); 7.3506 (0.7); 7.3341 (1.0); 7.3142 (0.8); 7.2690 (0.5); 7.2682 (0.6); 7.2674 (0.7); 7.2609 (53.8); 6.9968 (0.7); 6.9890 (1.4); 6.9699 (2.3); 6.9514 (1.3); 5.2985 (4.5); 3.7632 (0.8); 3.7434 (1.1); 3.1811 (0.7); 3.1527 (0.8); 2.4501 (0.8); 2.4211 (0.7); 2.2516 (0.7); 2.2357 (0.8); 2.2200 (0.8); 2.0025 (16.0); 2.0016 (16.0); 1.8683 (4.6); 1.8479 (3.2); 1.8128 (7.1); 1.7587 (0.6); 1.5736 (2.9); 1.4451 (2.4); 1.3083 (4.5); 0.0080 (0.7); -0.0002 (23.5); - 0.0085 (0.8) 1.71-247: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3680 (1.9); 7.3660 (1.9); 7.3267 (0.8); 7.2612 (16.3); 6.9885 (1.0); 6.9698 (1.2); 6.9678 (1.1); 6.9491 (0.9); 5.2984 (0.8); 4.1442 (0.9); 4.1264 (2.8); 4.1086 (2.8); 4.0909 (0.9); 1.9948 (4.8); 1.9934 (4.9); 1.8403 (16.0); 1.5769δ = 7.3680 (1.9); 7.3660 (1.9); 7.3267 (0.8); 7.2612 (16.3); 6.9885 (1.0); 6.9698 (1.2); 6.9678 (1.1); 6.9491 (0.9); 5.2984 (0.8); 4.1442 (0.9); 4.1264 (2.8); 4.1086 (2.8); 4.0909 (0.9); 1.9948 (4.8); 1.9934 (4.9); 1.8403 (16.0); 1.5769

(0.9); 1.2577 (2.6); 1.2399 (5.2); 1.2221 (2.4); -0.0002 (7.0) (0.9); 1.2577 (2.6); 1.2399 (5.2); 1.2221 (2.4); -0.0002 (7.0)

1.71-248: 1 H-NMR(400.0 MHz, CDCI3):  1.71-248: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5413 (1.9); 7.5392 (1.8); 7.3956 (0.5); 7.3858 (1.2); 7.3835 (1.6); 7.3812 (1.2); 7.3746 (0.9); 7.3535 (0.6); 7.2659 (0.5); 7.2651 (0.6); 7.2643 (0.7); 7.2634 (0.9); 7.2593 (33.1); 7.2522 (0.5); 7.0568 (1.1); 7.0376 (1.3); 7.0358 (1.2); 7.0169 (1.0); 2.1422 (0.8); 2.0418 (4.5); 2.0396 (4.5); 1.9680 (16.0); 1.6909 (0.5); 1.5441 (2.1); -0.0002 (13.5);δ = 7.5413 (1.9); 7.5392 (1.8); 7.3956 (0.5); 7.3858 (1.2); 7.3835 (1.6); 7.3812 (1.2); 7.3746 (0.9); 7.3535 (0.6); 7.2659 (0.5); 7.2651 (0.6); 7.2643 (0.7); 7.2634 (0.9); 7.2593 (33.1); 7.2522 (0.5); 7.0568 (1.1); 7.0376 (1.3); 7.0358 (1.2); 7.0169 (1.0); 2.1422 (0.8); 2.0418 (4.5); 2.0396 (4.5); 1.9680 (16.0); 1.6909 (0.5); 1.5441 (2.1); -0.0002 (13.5);

-0.0085 (0.5) -0.0085 (0.5)

1.71-249: 1 H-NMR(400.0 MHz, CDCI3):  1.71-249: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5568 (1.8); 7.5549 (1.8); 7.4040 (1.7); 7.4023 (1.6); 7.3670 (0.8); 7.2601 (24.0); 7.0519 (1.1); 7.0328 (1.3); 7.0122 (1.0); 7.0045 (1.8); 7.0024 (1.9); 5.2983 (0.8); 2.0424 (4.6); 2.0405 (4.7); 1.9549 (16.0); 1.5513 (3.2); -0.0002δ = 7.5568 (1.8); 7.5549 (1.8); 7.4040 (1.7); 7.4023 (1.6); 7.3670 (0.8); 7.2601 (24.0); 7.0519 (1.1); 7.0328 (1.3); 7.0122 (1.0); 7.0045 (1.8); 7.0024 (1.9); 5.2983 (0.8); 2.0424 (4.6); 2.0405 (4.7); 1.9549 (16.0); 1.5513 (3.2); -0.0002

(10.4) (10.4)

1.71-250: 1 H-NMR(400.0 MHz, CDCI3):  1.71-250: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.9848 (4.4); 7.5620 (1.9); 7.5600 (1.9); 7.3867 (0.9); 7.3657 (0.5); 7.2598 (22.7); 7.0757 (1.2); 7.0565 (1.4);δ = 7.9848 (4.4); 7.5620 (1.9); 7.5600 (1.9); 7.3867 (0.9); 7.3657 (0.5); 7.2598 (22.7); 7.0757 (1.2); 7.0565 (1.4);

7.0549 (1.3); 7.0358 (1.0); 5.2983 (0.8); 2.0489 (4.6); 2.0468 (4.6); 1.9808 (16.0); 1.5414 (3.3); -0.0002 (9.9) 7.0549 (1.3); 7.0358 (1.0); 5.2983 (0.8); 2.0489 (4.6); 2.0468 (4.6); 1.9808 (16.0); 1.5414 (3.3); -0.0002 (9.9)

1.71-251 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-251: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5199 (1.8); 7.5179 (1.9); 7.3532 (0.8); 7.3322 (0.5); 7.2585 (19.7); 7.2382 (1.4); 7.2369 (1.4); 7.2338 (0.8); 7.2224 (0.5); 7.2186 (1.3); 7.2170 (1.0); 7.1586 (0.6); 7.1555 (0.6); 7.1403 (0.9); 7.1350 (2.1); 7.1314 (1.8); 7.1183 (0.7); 7.1139 (1.3); 7.1109 (0.9); 7.0247 (1.0); 7.0056 (1.2); 7.0040 (1.2); 6.9848 (0.9); 2.0393 (4.5); 2.0374 (4.7); 1.8551 (16.0); 1.5430 (5.5); 1.2015 (1.0); 1.1973 (1.3); 1.1860 (0.8); 1.1291 (0.9); 1.1178 (1.3); 1.1140 (1.0); -0.0002δ = 7.5199 (1.8); 7.5179 (1.9); 7.3532 (0.8); 7.3322 (0.5); 7.2585 (19.7); 7.2382 (1.4); 7.2369 (1.4); 7.2338 (0.8); 7.2224 (0.5); 7.2186 (1.3); 7.2170 (1.0); 7.1586 (0.6); 7.1555 (0.6); 7.1403 (0.9); 7.1350 (2.1); 7.1314 (1.8); 7.1183 (0.7); 7.1139 (1.3); 7.1109 (0.9); 7.0247 (1.0); 7.0056 (1.2); 7.0040 (1.2); 6.9848 (0.9); 2.0393 (4.5); 2.0374 (4.7); 1.8551 (16.0); 1.5430 (5.5); 1.2015 (1.0); 1.1973 (1.3); 1.1860 (0.8); 1.1291 (0.9); 1.1178 (1.3); 1.1140 (1.0); -0.0002

(8-7) (8-7)

1.71-252: 1 H-NMR(400.0 MHz, CDCI3):  1.71-252: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3720 (2.9); 7.3704 (2.9); 7.3307 (0.9); 7.3254 (0.8); 7.3148 (0.6); 7.3096 (1.9); 7.3045 (0.6); 7.2936 (0.8); 7.2886 (1.2); 7.2728 (0.7); 7.2606 (41.8); 6.9736 (2.2); 6.9549 (2.5); 6.9528 (2.3); 6.9340 (1.9); 4.3524 (0.5); 4.3440 (0.7); 4.3356 (0.6); 3.6090 (1.0); 3.6009 (1.0); 3.5857 (1.2); 3.5776 (1.1); 3.3974 (1.3); 3.3791 (1.4); 3.3741 (1.3); 3.3535 (16.0); 2.6476 (0.6); 2.6321 (1.6); 2.6155 (1.3); 2.6076 (0.6); 2.6027 (0.5); 1.9949 (10.1); 1.9933 (10.2); 1.8434 (0.7); 1.8400 (0.6); 1.8309 (1.2); 1.8131 (15.1); 1.8078 (12.6); 1.7974 (1.8); 1.7881 (0.8); 1.7791 (0.6); 1.7762δ = 7.3720 (2.9); 7.3704 (2.9); 7.3307 (0.9); 7.3254 (0.8); 7.3148 (0.6); 7.3096 (1.9); 7.3045 (0.6); 7.2936 (0.8); 7.2886 (1.2); 7.2728 (0.7); 7.2606 (41.8); 6.9736 (2.2); 6.9549 (2.5); 6.9528 (2.3); 6.9340 (1.9); 4.3524 (0.5); 4.3440 (0.7); 4.3356 (0.6); 3.6090 (1.0); 3.6009 (1.0); 3.5857 (1.2); 3.5776 (1.1); 3.3974 (1.3); 3.3791 (1.4); 3.3741 (1.3); 3.3535 (16.0); 2.6476 (0.6); 2.6321 (1.6); 2.6155 (1.3); 2.6076 (0.6); 2.6027 (0.5); 1.9949 (10.1); 1.9933 (10.2); 1.8434 (0.7); 1.8400 (0.6); 1.8309 (1.2); 1.8131 (15.1); 1.8078 (12.6); 1.7974 (1.8); 1.7881 (0.8); 1.7791 (0.6); 1.7762

(0.6); 1.6512 (0.7); 1.6348 (0.7); 1.5630 (8.3); 0.0080 (0.6); -0.0002 (18.2); -0.0085 (0.6) (0.6); 1.6512 (0.7); 1.6348 (0.7); 1.5630 (8.3); 0.0080 (0.6); -0.0002 (18.2); -0.0085 (0.6)

1.71-253: 1 H-NMR(400.0 MHz, CDCI3):  1.71-253: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3432 (2.0); 7.3414 (2.0); 7.3184 (0.8); 7.2606 (16.6); 6.9843 (1.1); 6.9655 (1.3); 6.9635 (1.2); 6.9451 (0.9); 1.9927 (5.7); 1.8359 (16.0); 1.5675 (2.5); 1.5183 (0.6); 0.4215 (1.0); 0.4098 (0.8); 0.4046 (0.8); 0.3638 (0.5); 0.3552δ = 7.3432 (2.0); 7.3414 (2.0); 7.3184 (0.8); 7.2606 (16.6); 6.9843 (1.1); 6.9655 (1.3); 6.9635 (1.2); 6.9451 (0.9); 1.9927 (5.7); 1.8359 (16.0); 1.5675 (2.5); 1.5183 (0.6); 0.4215 (1.0); 0.4098 (0.8); 0.4046 (0.8); 0.3638 (0.5); 0.3552

(1.2) ; 0.3462 (1.0); -0.0002 (7.1) (1.2); 0.3462 (1.0); -0.0002 (7.1)

1.71-254: 1 H-NMR(400.0 MHz, CDCI3):  1.71-254: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3500 (1.8); 7.3480 (1.9); 7.3256 (0.8); 7.2603 (17.7); 6.9867 (1.0); 6.9679 (1.1); 6.9658 (1.0); 6.9471 (0.9); 2.9348 (0.6); 2.9110 (1.8); 2.8872 (1.9); 2.8634 (0.6); 1.9909 (4.8); 1.9894 (4.8); 1.8325 (16.0); 1.5531 (4.6); -0.0002δ = 7.3500 (1.8); 7.3480 (1.9); 7.3256 (0.8); 7.2603 (17.7); 6.9867 (1.0); 6.9679 (1.1); 6.9658 (1.0); 6.9471 (0.9); 2.9348 (0.6); 2.9110 (1.8); 2.8872 (1.9); 2.8634 (0.6); 1.9909 (4.8); 1.9894 (4.8); 1.8325 (16.0); 1.5531 (4.6); -0.0002

(7-6) (7-6)

1.71-255: 1 H-NMR(400.0 MHz, CDCI3):  1.71-255: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3883 (1.6); 7.3866 (1.7); 7.3285 (0.6); 7.2607 (25.9); 6.9865 (0.9); 6.9679 (1.1); 6.9474 (0.8); 5.2985 (1.6); 1.9973 (4.8); 1.8537 (16.0); 1.5592 (8.7); 0.9743 (1.2); 0.9672 (1.4); 0.9629 (1.2); 0.9556 (1.3); 0.7696 (1.0); 0.7622δ = 7.3883 (1.6); 7.3866 (1.7); 7.3285 (0.6); 7.2607 (25.9); 6.9865 (0.9); 6.9679 (1.1); 6.9474 (0.8); 5.2985 (1.6); 1.9973 (4.8); 1.8537 (16.0); 1.5592 (8.7); 0.9743 (1.2); 0.9672 (1.4); 0.9629 (1.2); 0.9556 (1.3); 0.7696 (1.0); 0.7622

(0.9); 0.7498 (1.0); 0.7424 (0.8); -0.0002 (11.1) (0.9); 0.7498 (1.0); 0.7424 (0.8); -0.0002 (11.1)

1.71-256: 1 H-NMR(400.0 MHz, CDCI3):  1.71-256: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5238 (3.0); 7.5219 (2.8); 7.3987 (0.5); 7.3776 (1.0); 7.3566 (0.6); 7.2606 (31.2); 7.0365 (1.3); 7.0169 (1.6); 6.9965 (1.3); 5.2985 (2.2); 3.7180 (0.7); 3.3030 (0.5); 3.2847 (0.5); 3.2761 (0.8); 2.0286 (5.4); 2.0269 (5.5); 1.8703δ = 7.5238 (3.0); 7.5219 (2.8); 7.3987 (0.5); 7.3776 (1.0); 7.3566 (0.6); 7.2606 (31.2); 7.0365 (1.3); 7.0169 (1.6); 6.9965 (1.3); 5.2985 (2.2); 3.7180 (0.7); 3.3030 (0.5); 3.2847 (0.5); 3.2761 (0.8); 2.0286 (5.4); 2.0269 (5.5); 1.8703

(16.0); 1.8250 (0.8); 1.7266 (0.8); 1.5521 (2.0); 1.4954 (5.4); 1.4643 (6.2); 1.4533 (33.8); -0.0002 (13.7) (16.0); 1.8250 (0.8); 1.7266 (0.8); 1.5521 (2.0); 1.4954 (5.4); 1.4643 (6.2); 1.4533 (33.8); -0.0002 (13.7)

1.71-258: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-258: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.4119 (1.2); 8.8917 (1.9); 7.7520 (2.5); 7.7501 (2.4); 7.5231 (0.6); 7.5183 (0.5); 7.5020 (1.0); 7.4810 (0.7); 7.2045 (1.5); 7.1845 (2.3); 7.1641 (1.3); 3.7313 (0.9); 3.3083 (142.3); 2.6738 (0.9); 2.6692 (1.2); 2.6648 (0.9); 2.6133 (0.6); 2.5227 (6.6); 2.5180 (8.8); 2.5093 (71.0); 2.5048 (143.0); 2.5002 (193.5); 2.4957 (133.3); 2.4911 (59.7); 2.3318 (0.8); 2.3270 (1.1); 2.3225 (0.7); 1.9148 (6.7); 1.7029 (16.0); 1.2357 (2.3); 0.0079 (1.2); -0.0002 (32.5); -0.0085 (1.0) 1.71-259: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 10.4119 (1.2); 8.8917 (1.9); 7.7520 (2.5); 7.7501 (2.4); 7.5231 (0.6); 7.5183 (0.5); 7.5020 (1.0); 7.4810 (0.7); 7.2045 (1.5); 7.1845 (2.3); 7.1641 (1.3); 3.7313 (0.9); 3.3083 (142.3); 2.6738 (0.9); 2.6692 (1.2); 2.6648 (0.9); 2.6133 (0.6); 2.5227 (6.6); 2.5180 (8.8); 2.5093 (71.0); 2.5048 (143.0); 2,5002 (193.5); 2.4957 (133.3); 2.4911 (59.7); 2.3318 (0.8); 2.3270 (1.1); 2.3225 (0.7); 1.9148 (6.7); 1.7029 (16.0); 1.2357 (2.3); 0.0079 (1.2); -0.0002 (32.5); -0.0085 (1.0) 1.71-259: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8571 (2.5); 7.5212 (0.9); 7.5003 (0.6); 7.2250 (1.5); 7.2050 (2.1); 7.1856 (1.1); 3.3358 (102.5); 2.6740 (2.4); 2.6695 (2.9); 2.5093 (188.0); 2.5049 (354.0); 2.5004 (462.0); 2.4959 (324.8); 2.4914 (152.9); 2.3996 (1.0); 2.3271 (2.7); 2.3224 (2.0); 1.9411 (6.5); 1.9287 (7.0); 1.7035 (16.0); 1.2584 (1.2); 1.2360 (4.1); 0.8535 (0.7); 0.0079 (2.4); -δ = 7.8571 (2.5); 7.5212 (0.9); 7.5003 (0.6); 7.2250 (1.5); 7.2050 (2.1); 7.1856 (1.1); 3.3358 (102.5); 2.6740 (2.4); 2.6695 (2.9); 2.5093 (188.0); 2.5049 (354.0); 2.5004 (462.0); 2.4959 (324.8); 2.4914 (152.9); 2.3996 (1.0); 2.3271 (2.7); 2.3224 (2.0); 1.9411 (6.5); 1.9287 (7.0); 1.7035 (16.0); 1.2584 (1.2); 1.2360 (4.1); 0.8535 (0.7); 0.0079 (2.4); -

0.0002 (64.9); -0.0085 (3.5) 0.0002 (64.9); -0.0085 (3.5)

1.71-260: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-260: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8541 (4.6); 7.8522 (4.7); 7.5628 (0.5); 7.5466 (1.0); 7.5415 (0.9); 7.5254 (1.8); 7.5090 (0.8); 7.5043 (1.2); 7.2288 (2.6); 7.2088 (3.7); 7.1887 (2.2); 3.5289 (11.8); 3.2286 (0.6); 2.6742 (1.4); 2.6695 (1.8); 2.6648 (1.4); 2.5506δ = 7.8541 (4.6); 7.8522 (4.7); 7.5628 (0.5); 7.5466 (1.0); 7.5415 (0.9); 7.5254 (1.8); 7.5090 (0.8); 7.5043 (1.2); 7.2288 (2.6); 7.2088 (3.7); 7.1887 (2.2); 3.5289 (11.8); 3.2286 (0.6); 2.6742 (1.4); 2.6695 (1.8); 2.6648 (1.4); 2.5506

(3.3) ; 2.5460 (3.2); 2.5230 (9.2); 2.5183 (12.4); 2.5096 (107.1); 2.5051 (218.6); 2.5005 (300.3); 2.4959 (206.6); 2.4913 (93.6); 2.3319 (1.3); 2.3273 (1.9); 2.3226 (1.3); 1.9274 (12.0); 1.7078 (16.0); 1.2368 (1.1); 0.0080 (1.2); - 0.0002 (34.4); -0.0085 (1.0) 1.71-261 : 1 H-NMR(400.0 MHz, d6-DMSO): (3.3); 2.5460 (3.2); 2.5230 (9.2); 2.5183 (12.4); 2.5096 (107.1); 2.5051 (218.6); 2.5005 (300.3); 2.4959 (206.6); 2.4913 (93.6); 2.3319 (1.3); 2.3273 (1.9); 2.3226 (1.3); 1.9274 (12.0); 1.7078 (16.0); 1.2368 (1.1); 0.0080 (1.2); - 0.0002 (34.4); -0.0085 (1.0) 1.71-261: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7822 (5.8); 7.7803 (6.0); 7.6852 (1.7); 7.6672 (1.7); 7.5588 (2.1); 7.5479 (1.2); 7.5313 (1.4); 7.5262 (1.1); 7.5103 (2.4); 7.5057 (0.9); 7.4936 (1.1); 7.4893 (1.5); 7.4727 (0.7); 7.2241 (0.5); 7.2136 (3.2); 7.1934 (4.8); 7.1731 (2.8); 4.3953 (0.9); 4.3768 (0.9); 4.3615 (0.6); 3.4977 (15.0); 3.4707 (6.0); 3.4646 (5.3); 3.4454 (3.2); 2.9604 (1.6); 2.9484 (1.6); 2.9354 (1.5); 2.9238 (1.5); 2.6742 (1.3); 2.6694 (1.8); 2.6648 (1.4); 2.6061 (1.2); 2.6018 (1.0); 2.5604 (1.3); 2.5557 (1.7); 2.5512 (1.6); 2.5463 (1.0); 2.5412 (0.8); 2.5229 (6.9); 2.5183 (9.6); 2.5095 (96.3); 2.5050 (199.9); 2.5004 (276.8); 2.4958 (192.4); 2.4913 (88.4); 2.4671 (1.4); 2.4552 (1.9); 2.4506 (2.5); 2.4460 (2.3); 2.4350 (2.6); 2.4129 (2.7); 2.4052 (1.7); 2.4009 (2.0); 2.3929 (3.2); 2.3708 (2.5); 2.3511 (0.5); 2.3316 (1.2); 2.3272 (1.8); 2.3225δ = 7.7822 (5.8); 7.7803 (6.0); 7.6852 (1.7); 7.6672 (1.7); 7.5588 (2.1); 7.5479 (1.2); 7.5313 (1.4); 7.5262 (1.1); 7.5103 (2.4); 7.5057 (0.9); 7.4936 (1.1); 7.4893 (1.5); 7.4727 (0.7); 7.2241 (0.5); 7.2136 (3.2); 7.1934 (4.8); 7.1731 (2.8); 4.3953 (0.9); 4.3768 (0.9); 4.3615 (0.6); 3.4977 (15.0); 3.4707 (6.0); 3.4646 (5.3); 3.4454 (3.2); 2.9604 (1.6); 2.9484 (1.6); 2.9354 (1.5); 2.9238 (1.5); 2.6742 (1.3); 2.6694 (1.8); 2.6648 (1.4); 2.6061 (1.2); 2.6018 (1.0); 2.5604 (1.3); 2.5557 (1.7); 2.5512 (1.6); 2.5463 (1.0); 2.5412 (0.8); 2.5229 (6.9); 2.5183 (9.6); 2.5095 (96.3); 2.5050 (199.9); 2.5004 (276.8); 2.4958 (192.4); 2.4913 (88.4); 2.4671 (1.4); 2.4552 (1.9); 2.4506 (2.5); 2.4460 (2.3); 2.4350 (2.6); 2.4129 (2.7); 2.4052 (1.7); 2.4009 (2.0); 2.3929 (3.2); 2.3708 (2.5); 2.3511 (0.5); 2.3316 (1.2); 2.3272 (1.8); 2.3225

(1.3) ; 2.0670 (2.6); 2.0529 (2.5); 2.0248 (2.0); 2.0108 (2.0); 1.9275 (14.6); 1.7000 (15.9); 1.6904 (16.0); 1.2347 (0.8);(1.3); 2.0670 (2.6); 2.0529 (2.5); 2.0248 (2.0); 2.0108 (2.0); 1.9275 (14.6); 1.7000 (15.9); 1.6904 (16.0); 1.2347 (0.8);

0.0080 (1.0); -0.0002 (29.5); -0.0085 (0.9) 0.0080 (1.0); -0.0002 (29.5); -0.0085 (0.9)

1.71-262: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-262: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8333 (2.9); 7.8313 (2.9); 7.7798 (1.0); 7.5353 (0.8); 7.5283 (0.8); 7.5157 (0.9); 7.5072 (1.2); 7.4861 (0.8); 7.2099 (1.5); 7.1897 (2.2); 7.1694 (1.3); 4.2490 (0.6); 4.2244 (0.6); 3.3257 (17.7); 3.1766 (1.1); 3.1637 (0.8); 3.1533 (1.2); 3.1402 (0.8); 2.5229 (1.9); 2.5183 (2.6); 2.5095 (27.6); 2.5050 (57.8); 2.5004 (79.6); 2.4958 (54.0); 2.4912 (24.0); 2.2603 (0.5); 1.9877 (0.7); 1.9225 (6.6); 1.8268 (0.6); 1.8012 (0.6); 1.7966 (0.6); 1.7168 (16.0); -0.0002 (1.1) 1.71-264: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.8333 (2.9); 7.8313 (2.9); 7.7798 (1.0); 7.5353 (0.8); 7.5283 (0.8); 7.5157 (0.9); 7.5072 (1.2); 7.4861 (0.8); 7.2099 (1.5); 7.1897 (2.2); 7.1694 (1.3); 4.2490 (0.6); 4.2244 (0.6); 3.3257 (17.7); 3.1766 (1.1); 3.1637 (0.8); 3.1533 (1.2); 3.1402 (0.8); 2.5229 (1.9); 2.5183 (2.6); 2.5095 (27.6); 2.5050 (57.8); 2.5004 (79.6); 2.4958 (54.0); 2.4912 (24.0); 2.2603 (0.5); 1.9877 (0.7); 1.9225 (6.6); 1.8268 (0.6); 1.8012 (0.6); 1.7966 (0.6); 1.7168 (16.0); -0.0002 (1.1) 1.71-264: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.5413 (2.2); 7.5452 (1.6); 7.5432 (1.6); 7.3491 (0.8); 7.3332 (0.5); 7.3280 (0.7); 7.2598 (35.3); 7.0171 (1.0); 6.9979 (1.2); 6.9961 (1.3); 6.9772 (1.0); 4.0180 (2.3); 4.0046 (2.3); 2.0513 (0.5); 2.0490 (0.6); 2.0412 (4.2); 2.0392δ = 9.5413 (2.2); 7.5452 (1.6); 7.5432 (1.6); 7.3491 (0.8); 7.3332 (0.5); 7.3280 (0.7); 7.2598 (35.3); 7.0171 (1.0); 6.9979 (1.2); 6.9961 (1.3); 6.9772 (1.0); 4.0180 (2.3); 4.0046 (2.3); 2.0513 (0.5); 2.0490 (0.6); 2.0412 (4.2); 2.0392

(4.2) ; 2.0117 (0.7); 1.9938 (0.5); 1.9036 (16.0); 1.8787 (2.2); 1.8452 (0.7); 1.8352 (0.9); 1.8316 (1.1); 1.4320 (0.8); -(4.2); 2.0117 (0.7); 1.9938 (0.5); 1.9036 (16.0); 1.8787 (2.2); 1.8452 (0.7); 1.8352 (0.9); 1.8316 (1.1); 1.4320 (0.8); -

0.0002 (13.5) 0.0002 (13.5)

1.71-265: 1 H-NMR(400.0 MHz, CDCI3):  1.71-265: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.4455 (5.4); 9.4439 (5.4); 7.5448 (4.1); 7.5428 (4.2); 7.5229 (1.4); 7.5209 (1.4); 7.5190 (1.0); 7.3888 (0.5); 7.3779 (0.7); 7.3727 (1.3); 7.3673 (0.8); 7.3568 (1.0); 7.3517 (2.0); 7.3466 (0.8); 7.3353 (0.8); 7.3306 (1.3); 7.3146 (0.7); 7.2673 (0.5); 7.2665 (0.6); 7.2657 (0.7); 7.2649 (0.9); 7.2641 (1.2); 7.2601 (69.3); 7.2544 (1.7); 7.2536 (1.5); 7.2528 (1.3); 7.2520 (1.1); 7.2504 (0.8); 7.2496 (0.8); 7.2487 (0.7); 7.2479 (0.6); 7.2471 (0.6); 7.2463 (0.6); 7.2455 (0.6); 7.2448 (0.5); 7.2003 (0.5); 7.0341 (0.8); 7.0169 (2.8); 7.0154 (2.5); 7.0105 (0.8); 7.0062 (0.6); 6.9975 (3.0); 6.9960 (3.3); 6.9876 (0.7); 6.9835 (0.6); 6.9768 (2.3); 6.9663 (0.5); 4.2952 (1.0); 4.2769 (1.6); 4.2586 (1.1); 2.0537δ = 9.4455 (5.4); 9.4439 (5.4); 7.5448 (4.1); 7.5428 (4.2); 7.5229 (1.4); 7.5209 (1.4); 7.5190 (1.0); 7.3888 (0.5); 7.3779 (0.7); 7.3727 (1.3); 7.3673 (0.8); 7.3568 (1.0); 7.3517 (2.0); 7.3466 (0.8); 7.3353 (0.8); 7.3306 (1.3); 7.3146 (0.7); 7.2673 (0.5); 7.2665 (0.6); 7.2657 (0.7); 7.2649 (0.9); 7.2641 (1.2); 7.2601 (69.3); 7.2544 (1.7); 7.2536 (1.5); 7.2528 (1.3); 7.2520 (1.1); 7.2504 (0.8); 7.2496 (0.8); 7.2487 (0.7); 7.2479 (0.6); 7.2471 (0.6); 7.2463 (0.6); 7.2455 (0.6); 7.2448 (0.5); 7.2003 (0.5); 7.0341 (0.8); 7.0169 (2.8); 7.0154 (2.5); 7.0105 (0.8); 7.0062 (0.6); 6.9975 (3.0); 6.9960 (3.3); 6.9876 (0.7); 6.9835 (0.6); 6.9768 (2.3); 6.9663 (0.5); 4.2952 (1.0); 4.2769 (1.6); 4.2586 (1.1); 2.0537

(1.4) ; 2.0512 (3.1); 2.0490 (3.4); 2.0465 (2.1); 2.0407 (10.5); 2.0386 (10.7); 1.9082 (14.4); 1.8864 (14.8); 1.8790(1.4); 2.0512 (3.1); 2.0490 (3.4); 2.0465 (2.1); 2.0407 (10.5); 2.0386 (10.7); 1.9082 (14.4); 1.8864 (14.8); 1.8790

(16.0); 1.8323 (0.5); 1.4320 (1.7); 1.2690 (8.3); 1.2505 (8.4); 0.0080 (0.7); -0.0002 (27.9); -0.0085 (1.1) (16.0); 1.8323 (0.5); 1.4320 (1.7); 1.2690 (8.3); 1.2505 (8.4); 0.0080 (0.7); -0.0002 (27.9); -0.0085 (1.1)

1.71-266: 1 H-NMR(400.0 MHz, CDCI3):  1.71-266: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5096 (1.1); 7.5076 (1.1); 7.3434 (0.6); 7.2603 (13.5); 7.0132 (0.7); 6.9941 (0.8); 6.9923 (0.7); 6.9734 (0.6); 4.3063 (1.0); 4.2922 (0.5); 3.3271 (1.1); 3.3127 (2.1); 3.2998 (16.0); 2.0229 (3.0); 2.0210 (3.0); 1.8719 (10.9); -δ = 7.5096 (1.1); 7.5076 (1.1); 7.3434 (0.6); 7.2603 (13.5); 7.0132 (0.7); 6.9941 (0.8); 6.9923 (0.7); 6.9734 (0.6); 4.3063 (1.0); 4.2922 (0.5); 3.3271 (1.1); 3.3127 (2.1); 3.2998 (16.0); 2.0229 (3.0); 2.0210 (3.0); 1.8719 (10.9); -

0.0002 (5.8) 0.0002 (5.8)

1.71-267: 1 H-NMR(400.0 MHz, CDCI3):  1.71-267: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5093 (1.9); 7.5074 (1.8); 7.3428 (0.8); 7.3217 (0.5); 7.2601 (27.6); 7.0127 (1.1); 6.9938 (1.3); 6.9921 (1.2); 6.9731 (1.0); 4.1011 (1.2); 4.0905 (2.1); 3.3331 (12.4); 3.3133 (11.8); 2.0202 (5.0); 2.0186 (5.0); 1.8681 (16.0);δ = 7.5093 (1.9); 7.5074 (1.8); 7.3428 (0.8); 7.3217 (0.5); 7.2601 (27.6); 7.0127 (1.1); 6.9938 (1.3); 6.9921 (1.2); 6.9731 (1.0); 4.1011 (1.2); 4.0905 (2.1); 3.3331 (12.4); 3.3133 (11.8); 2.0202 (5.0); 2.0186 (5.0); 1.8681 (16.0);

1.5556 (1.6); 1.0458 (4.0); 1.0291 (4.1); -0.0002 (11.6) 1.5556 (1.6); 1.0458 (4.0); 1.0291 (4.1); -0.0002 (11.6)

1.71-268: 1 H-NMR(400.0 MHz, CDCI3):  1.71-268: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5291 (1.6); 7.5272 (1.7); 7.3543 (0.8); 7.2598 (56.7); 7.0216 (1.1); 7.0021 (1.2); 6.9959 (0.6); 6.9815 (0.9); 3.6697 (1.3); 3.6574 (1.7); 3.6443 (1.6); 3.3761 (0.8); 3.3620 (1.4); 3.3507 (1.2); 3.3364 (0.7); 3.2448 (1.2); 2.0436δ = 7.5291 (1.6); 7.5272 (1.7); 7.3543 (0.8); 7.2598 (56.7); 7.0216 (1.1); 7.0021 (1.2); 6.9959 (0.6); 6.9815 (0.9); 3.6697 (1.3); 3.6574 (1.7); 3.6443 (1.6); 3.3761 (0.8); 3.3620 (1.4); 3.3507 (1.2); 3.3364 (0.7); 3.2448 (1.2); 2.0436

(1.1); 2.0296 (4.4); 2.0276 (4.5); 1.8810 (16.0); 1.2586 (0.7); 0.0079 (0.7); -0.0002 (24.9); -0.0085 (1.1) (1.1); 2.0296 (4.4); 2.0276 (4.5); 1.8810 (16.0); 1.2586 (0.7); 0.0079 (0.7); -0.0002 (24.9); -0.0085 (1.1)

1.71-269: 1 H-NMR(400.0 MHz, CDCI3):  1.71-269: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5307 (3.5); 7.5288 (3.5); 7.5186 (0.6); 7.3728 (0.8); 7.3679 (0.7); 7.3567 (0.5); 7.3517 (1.7); 7.3467 (0.6); 7.3359 (0.7); 7.3307 (1.0); 7.2598 (101.8); 7.0200 (2.3); 7.0006 (2.7); 6.9961 (1.6); 6.9908 (0.6); 6.9801 (2.2); 6.9693 (0.7); 6.9657 (0.6); 3.8714 (0.6); 3.8633 (0.6); 3.8537 (0.7); 3.8471 (0.7); 3.8377 (0.6); 3.8294 (0.6); 3.3508 (0.6); 3.3426 (0.6); 3.3351 (0.6); 3.3269 (0.6); 3.3160 (0.9); 3.3078 (0.8); 3.3004 (0.9); 3.2921 (0.8); 3.1303 (1.0); 3.1162 (1.0); 3.1122 (1.0); 3.0982 (1.0); 3.0956 (0.8); 3.0815 (0.7); 3.0775 (0.7); 3.0635 (0.7); 2.0436 (1.2); 2.0260 (9.8); 2.0243 (9.6); 1.9076 (0.5); 1.9010 (0.6); 1.8841 (16.0); 1.8817 (16.0); 1.8703 (1.2); 1.7446 (0.6); 1.7207 (0.5); 1.2587δ = 7.5307 (3.5); 7.5288 (3.5); 7.5186 (0.6); 7.3728 (0.8); 7.3679 (0.7); 7.3567 (0.5); 7.3517 (1.7); 7.3467 (0.6); 7.3359 (0.7); 7.3307 (1.0); 7.2598 (101.8); 7.0200 (2.3); 7,0006 (2.7); 6.9961 (1.6); 6.9908 (0.6); 6.9801 (2.2); 6.9693 (0.7); 6.9657 (0.6); 3.8714 (0.6); 3.8633 (0.6); 3.8537 (0.7); 3.8471 (0.7); 3.8377 (0.6); 3.8294 (0.6); 3.3508 (0.6); 3.3426 (0.6); 3.3351 (0.6); 3.3269 (0.6); 3.3160 (0.9); 3.3078 (0.8); 3.3004 (0.9); 3.2921 (0.8); 3.1303 (1.0); 3.1162 (1.0); 3.1122 (1.0); 3.0982 (1.0); 3.0956 (0.8); 3.0815 (0.7); 3.0775 (0.7); 3.0635 (0.7); 2.0436 (1.2); 2.0260 (9.8); 2.0243 (9.6); 1.9076 (0.5); 1.9010 (0.6); 1.8841 (16.0); 1.8817 (16.0); 1.8703 (1.2); 1.7446 (0.6); 1.7207 (0.5); 1.2587

(0.8); 1.1174 (9.5); 1.1016 (9.4); 1.0926 (0.5); 0.8819 (0.7); 0.0080 (1.2); -0.0002 (43.8); -0.0086 (1.4) (0.8); 1.1174 (9.5); 1.1016 (9.4); 1.0926 (0.5); 0.8819 (0.7); 0.0080 (1.2); -0.0002 (43.8); -0.0086 (1.4)

1.71-270: 1 H-NMR(400.0 MHz, CDCI3):  1.71-270: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5271 (3.8); 7.5254 (3.8); 7.5188 (0.7); 7.3763 (0.9); 7.3714 (0.8); 7.3603 (0.6); 7.3553 (1.8); 7.3502 (0.6); 7.3393 (0.8); 7.3341 (1.1); 7.3182 (0.5); 7.2599 (92.5); 7.0205 (2.3); 7.0012 (2.8); 6.9807 (2.1); 3.9900 (0.8); 3.9807 (0.8); 3.9727 (0.8); 3.9633 (0.8); 3.6028 (1.5); 3.5934 (1.5); 3.5750 (2.3); 3.5656 (2.1); 3.4666 (2.3); 3.4496 (2.1); 3.4388 (1.6); 3.4218 (1.5); 2.0437 (2.2); 2.0271 (10.5); 2.0254 (10.6); 1.8964 (0.6); 1.8760 (15.7); 1.8700 (16.0);δ = 7.5271 (3.8); 7.5254 (3.8); 7.5188 (0.7); 7.3763 (0.9); 7.3714 (0.8); 7.3603 (0.6); 7.3553 (1.8); 7.3502 (0.6); 7.3393 (0.8); 7.3341 (1.1); 7.3182 (0.5); 7.2599 (92.5); 7.0205 (2.3); 7.0012 (2.8); 6.9807 (2.1); 3.9900 (0.8); 3.9807 (0.8); 3.9727 (0.8); 3.9633 (0.8); 3.6028 (1.5); 3.5934 (1.5); 3.5750 (2.3); 3.5656 (2.1); 3.4666 (2.3); 3.4496 (2.1); 3.4388 (1.6); 3.4218 (1.5); 2.0437 (2.2); 2.0271 (10.5); 2.0254 (10.6); 1.8964 (0.6); 1.8760 (15.7); 1.8700 (16.0);

1.2765 (0.6); 1.2587 (1.3); 1.2408 (0.6); 1.0924 (8.3); 1.0752 (8.3); 0.0080 (1.1); -0.0002 (39.6); -0.0085 (1.3) 1.2765 (0.6); 1.2587 (1.3); 1.2408 (0.6); 1.0924 (8.3); 1.0752 (8.3); 0.0080 (1.1); -0.0002 (39.6); -0.0085 (1.3)

1.71-271 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-271: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4366 (1.9); 7.4347 (1.8); 7.3667 (0.6); 7.3456 (0.9); 7.3294 (0.5); 7.3246 (0.6); 7.2593 (24.8); 6.9999 (1.1);δ = 7.4366 (1.9); 7.4347 (1.8); 7.3667 (0.6); 7.3456 (0.9); 7.3294 (0.5); 7.3246 (0.6); 7.2593 (24.8); 6.9999 (1.1);

6.9810 (1.3); 6.9602 (0.9); 2.0262 (5.2); 2.0246 (5.0); 1.8655 (16.0); 1.5339 (4.6); 0.0079 (0.6); -0.0002 (9.2) 6.9810 (1.3); 6.9602 (0.9); 2.0262 (5.2); 2.0246 (5.0); 1.8655 (16.0); 1.5339 (4.6); 0.0079 (0.6); -0.0002 (9.2)

1.71-272: 1 H-NMR(400.0 MHz, CDCI3):  1.71-272: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3363 (4.1); 7.3247 (1.9); 7.3090 (2.9); 7.3038 (1.5); 7.2927 (2.0); 7.2880 (2.2); 7.2602 (46.9); 6.9961 (0.7); 6.9881 (0.8); 6.9771 (3.4); 6.9586 (4.2); 6.9381 (2.7); 4.7330 (0.9); 3.2189 (0.8); 3.1837 (0.8); 2.7086 (0.8); 2.6737δ = 7.3363 (4.1); 7.3247 (1.9); 7.3090 (2.9); 7.3038 (1.5); 7.2927 (2.0); 7.2880 (2.2); 7.2602 (46.9); 6.9961 (0.7); 6.9881 (0.8); 6.9771 (3.4); 6.9586 (4.2); 6.9381 (2.7); 4.7330 (0.9); 3.2189 (0.8); 3.1837 (0.8); 2.7086 (0.8); 2.6737

(1.3) ; 2.6397 (0.6); 1.9871 (16.0); 1.8314 (15.6); 1.8197 (10.4); 1.7194 (0.7); 1.7004 (0.9); 1.6833 (1.1); 1.6660 (1.2); 1.6452 (1.2); 1.6054 (2.0); 1.5520 (10.0); 1.5297 (1.5); 1.5110 (2.0); 1.4925 (2.2); 1.4771 (2.8); 1.3607 (0.9); 1.3269 (0.9); 1.0676 (0.7); 0.8950 (2.7); 0.8766 (4.6); 0.8582 (2.3); 0.6548 (0.6); -0.0002 (18.2); -0.0085 (0.8) 1.71-273: 1 H-NMR(400.0 MHz, CDCI3): (1.3); 2.6397 (0.6); 1.9871 (16.0); 1.8314 (15.6); 1.8197 (10.4); 1.7194 (0.7); 1.7004 (0.9); 1.6833 (1.1); 1.6660 (1.2); 1.6452 (1.2); 1.6054 (2.0); 1.5520 (10.0); 1.5297 (1.5); 1.5110 (2.0); 1.4925 (2.2); 1.4771 (2.8); 1.3607 (0.9); 1.3269 (0.9); 1.0676 (0.7); 0.8950 (2.7); 0.8766 (4.6); 0.8582 (2.3); 0.6548 (0.6); -0.0002 (18.2); -0.0085 (0.8) 1.71-273: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5187 (0.6); 7.3403 (5.8); 7.3385 (5.9); 7.3303 (2.1); 7.3248 (1.9); 7.3092 (3.1); 7.3041 (1.6); 7.2930 (2.0); 7.2882 (2.3); 7.2599 (92.5); 7.2092 (0.5); 6.9957 (0.8); 6.9885 (0.7); 6.9773 (3.3); 6.9588 (4.1); 6.9380 (2.8); 1.9836 (16.0); 1.9823 (16.0); 1.8478 (11.6); 1.8251 (4.1); 1.7364 (0.8); 1.5450 (15.7); 1.3845 (1.2); 1.3748 (1.6); 1.3643δ = 7.5187 (0.6); 7.3403 (5.8); 7.3385 (5.9); 7.3303 (2.1); 7.3248 (1.9); 7.3092 (3.1); 7.3041 (1.6); 7.2930 (2.0); 7.2882 (2.3); 7.2599 (92.5); 7.2092 (0.5); 6.9957 (0.8); 6.9885 (0.7); 6.9773 (3.3); 6.9588 (4.1); 6.9380 (2.8); 1.9836 (16.0); 1.9823 (16.0); 1.8478 (11.6); 1.8251 (4.1); 1.7364 (0.8); 1.5450 (15.7); 1.3845 (1.2); 1.3748 (1.6); 1.3643

(1.4); 1.3510 (1.2); 1.3412 (1.5); 1.3308 (1.3); 1.2555 (2.7); 0.9949 (1.6); -0.0002 (33.6); -0.0085 (1.1) (1.4); 1.3510 (1.2); 1.3412 (1.5); 1.3308 (1.3); 1.2555 (2.7); 0.9949 (1.6); -0.0002 (33.6); -0.0085 (1.1)

1.71-274: 1 H-NMR(400.0 MHz, CDCI3):  1.71-274: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5186 (0.9); 7.4546 (1.9); 7.3593 (1.6); 7.3495 (1.3); 7.3340 (2.2); 7.3121 (5.4); 7.3103 (5.3); 7.2923 (2.7); 7.2635 (18.5); 7.2597 (114.0); 6.9958 (1.1); 6.9798 (2.6); 6.9628 (3.4); 6.9422 (2.3); 6.9281 (0.9); 3.8576 (0.6); 3.7179 (8.7); 2.0061 (5.1); 1.9888 (4.2); 1.9821 (4.0); 1.9723 (8.8); 1.8713 (16.0); 1.8468 (5.5); 1.8250 (4.7); 1.8110δ = 7.5186 (0.9); 7.4546 (1.9); 7.3593 (1.6); 7.3495 (1.3); 7.3340 (2.2); 7.3121 (5.4); 7.3103 (5.3); 7.2923 (2.7); 7.2635 (18.5); 7.2597 (114.0); 6.9958 (1.1); 6.9798 (2.6); 6.9628 (3.4); 6.9422 (2.3); 6.9281 (0.9); 3.8576 (0.6); 3.7179 (8.7); 2.0061 (5.1); 1.9888 (4.2); 1.9821 (4.0); 1.9723 (8.8); 1.8713 (16.0); 1.8468 (5.5); 1.8250 (4.7); 1.8110

(4.1) ; 1.8038 (4.5); 1.6899 (0.8); 1.5414 (18.9); 1.4267 (1.0); 1.4097 (1.0); 1.2674 (2.6); 1.2525 (2.8); 1.0254 (2.3); 1.0077 (2.1); 0.9221 (1.1); 0.9055 (1.2); 0.8645 (5.9); 0.8545 (3.7); 0.8486 (5.4); 0.8386 (2.7); 0.6824 (0.5); -0.0002(4.1); 1.8038 (4.5); 1.6899 (0.8); 1.5414 (18.9); 1.4267 (1.0); 1.4097 (1.0); 1.2674 (2.6); 1.2525 (2.8); 1.0254 (2.3); 1.0077 (2.1); 0.9221 (1.1); 0.9055 (1.2); 0.8645 (5.9); 0.8545 (3.7); 0.8486 (5.4); 0.8386 (2.7); 0.6824 (0.5); -0.0002

(40.4); -0.0084 (1.4) (40.4); -0.0084 (1.4)

1.71-275: 1 H-NMR(400.0 MHz, CDCI3):  1.71-275: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3619 (5.6); 7.3601 (5.6); 7.3475 (1.4); 7.3420 (1.3); 7.3315 (1.1); 7.3264 (2.4); 7.3214 (1.1); 7.3100 (1.5); 7.3055 (1.6); 7.2895 (1.0); 7.2603 (49.3); 6.9965 (0.7); 6.9876 (3.0); 6.9691 (3.6); 6.9585 (0.6); 6.9483 (2.5); 5.2983 (2.3); 2.9579 (2.1); 2.9260 (1.7); 1.9949 (15.5); 1.8475 (16.0); 1.7978 (1.2); 1.5512 (8.0); 0.0078 (1.0); -0.0002δ = 7.3619 (5.6); 7.3601 (5.6); 7.3475 (1.4); 7.3420 (1.3); 7.3315 (1.1); 7.3264 (2.4); 7.3214 (1.1); 7.3100 (1.5); 7.3055 (1.6); 7.2895 (1.0); 7.2603 (49.3); 6.9965 (0.7); 6.9876 (3.0); 6.9691 (3.6); 6.9585 (0.6); 6.9483 (2.5); 5.2983 (2.3); 2.9579 (2.1); 2.9260 (1.7); 1.9949 (15.5); 1.8475 (16.0); 1.7978 (1.2); 1.5512 (8.0); 0.0078 (1.0); -0.0002

(18.6); -0.0085 (0.6) (18.6); -0.0085 (0.6)

1.71-276: 1 H-NMR(400.0 MHz, CDCI3):  1.71-276: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3384 (1.7); 7.3120 (0.9); 7.2955 (0.5); 7.2912 (0.5); 7.2602 (15.8); 7.2580 (14.5); 6.9775 (1.3); 6.9606 (1.7); 6.9587 (1.8); 6.9400 (1.1); 1.9873 (7.0); 1.8389 (16.0); 1.5507 (2.7); 1.5491 (2.5); 1.2841 (2.1); 0.8673 (2.8); -0.0002δ = 7.3384 (1.7); 7.3120 (0.9); 7.2955 (0.5); 7.2912 (0.5); 7.2602 (15.8); 7.2580 (14.5); 6.9775 (1.3); 6.9606 (1.7); 6.9587 (1.8); 6.9400 (1.1); 1.9873 (7.0); 1.8389 (16.0); 1.5507 (2.7); 1.5491 (2.5); 1.2841 (2.1); 0.8673 (2.8); -0.0002

(6.0); -0.0024 (5.6) (6.0); -0.0024 (5.6)

1.71-277: 1 H-NMR(400.0 MHz, CDCI3):  1.71-277: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3288 (2.4); 7.3083 (4.4); 7.2625 (26.9); 7.2602 (29.6); 6.9814 (2.5); 6.9635 (3.9); 6.9440 (2.3); 3.0859 (0.7); 3.0553 (0.8); 1.9889 (11.5); 1.8489 (4.9); 1.8239 (16.0); 1.7328 (1.4); 1.6983 (1.4); 1.5497 (5.2); 1.2606 (0.7); 0.8584δ = 7.3288 (2.4); 7.3083 (4.4); 7.2625 (26.9); 7.2602 (29.6); 6.9814 (2.5); 6.9635 (3.9); 6.9440 (2.3); 3.0859 (0.7); 3.0553 (0.8); 1.9889 (11.5); 1.8489 (4.9); 1.8239 (16.0); 1.7328 (1.4); 1.6983 (1.4); 1.5497 (5.2); 1.2606 (0.7); 0.8584

(1.6); 0.6701 (1.9); 0.6415 (2.5); 0.6113 (2.0); 0.5792 (0.9); 0.0021 (9.8); -0.0002 (11.1) (1.6); 0.6701 (1.9); 0.6415 (2.5); 0.6113 (2.0); 0.5792 (0.9); 0.0021 (9.8); -0.0002 (11.1)

1.71-278: 1 H-NMR(400.0 MHz, CDCI3):  1.71-278: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3325 (2.6); 7.3108 (0.9); 7.2946 (0.6); 7.2900 (0.6); 7.2600 (17.5); 6.9774 (1.1); 6.9582 (1.4); 6.9392 (1.0);δ = 7.3325 (2.6); 7.3108 (0.9); 7.2946 (0.6); 7.2900 (0.6); 7.2600 (17.5); 6.9774 (1.1); 6.9582 (1.4); 6.9392 (1.0);

1.9902 (6.3); 1.8255 (16.0); 1.5500 (3.0); 0.8911 (15.8); -0.0002 (6.9) 1.9902 (6.3); 1.8255 (16.0); 1,500 (3.0); 0.8911 (15.8); -0.0002 (6.9)

1.71-279: 1 H-NMR(400.0 MHz, CDCI3):  1.71-279: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3556 (2.8); 7.3449 (0.7); 7.3399 (0.7); 7.3235 (1.0); 7.3030 (0.8); 7.2601 (15.8); 7.2577 (13.6); 6.9832 (1.3); 6.9643 (1.9); 6.9458 (1.2); 2.6170 (0.6); 2.5841 (1.0); 2.5510 (0.6); 1.9901 (7.5); 1.8381 (16.0); 1.5442 (2.2); -0.0002δ = 7.3556 (2.8); 7.3449 (0.7); 7.3399 (0.7); 7.3235 (1.0); 7.3030 (0.8); 7.2601 (15.8); 7.2577 (13.6); 6.9832 (1.3); 6.9643 (1.9); 6.9458 (1.2); 2.6170 (0.6); 2.5841 (1.0); 2.5510 (0.6); 1.9901 (7.5); 1.8381 (16.0); 1.5442 (2.2); -0.0002

(6.0) ; -0.0026 (5.5) (6.0); -0.0026 (5.5)

1.71-280: 1 H-NMR(400.0 MHz, CDCI3):  1.71-280: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5188 (0.6); 7.3639 (3.8); 7.3396 (1.6); 7.3343 (1.5); 7.3185 (2.7); 7.3133 (1.4); 7.3024 (1.7); 7.2975 (1.9); 7.2816 (1.7); 7.2599 (64.3); 7.2099 (0.5); 6.9959 (0.9); 6.9918 (0.8); 6.9810 (3.1); 6.9622 (3.9); 6.9414 (2.7); 5.2983δ = 7.5188 (0.6); 7.3639 (3.8); 7.3396 (1.6); 7.3343 (1.5); 7.3185 (2.7); 7.3133 (1.4); 7.3024 (1.7); 7.2975 (1.9); 7.2816 (1.7); 7.2599 (64.3); 7.2099 (0.5); 6.9959 (0.9); 6.9918 (0.8); 6.9810 (3.1); 6.9622 (3.9); 6.9414 (2.7); 5.2983

(1.2) ; 2.6942 (1.5); 2.6661 (1.9); 2.6613 (1.7); 2.6330 (1.7); 2.5760 (0.6); 1.9931 (15.8); 1.9612 (1.3); 1.9362 (1.3); 1.8368 (16.0); 1.8197 (10.6); 1.5449 (8.6); 1.4867 (0.6); 1.4542 (1.0); 1.4439 (0.9); 1.4239 (1.0); 1.3929 (0.6); 0.0079(1.2); 2.6942 (1.5); 2.6661 (1.9); 2.6613 (1.7); 2.6330 (1.7); 2.5760 (0.6); 1.9931 (15.8); 1.9612 (1.3); 1.9362 (1.3); 1.8368 (16.0); 1.8197 (10.6); 1.5449 (8.6); 1.4867 (0.6); 1.4542 (1.0); 1.4439 (0.9); 1.4239 (1.0); 1.3929 (0.6); 0.0079

(1.3) ; -0.0002 (23.2); -0.0084 (1.2) (1.3); -0.0002 (23.2); -0.0084 (1.2)

1.71-281 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-281: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5185 (0.9); 7.3580 (0.9); 7.3422 (1.5); 7.3366 (1.2); 7.3263 (1.2); 7.3210 (4.2); 7.3164 (3.4); 7.3096 (0.9); 7.3051 (1.2); 7.3002 (1.7); 7.2844 (0.9); 7.2734 (0.5); 7.2726 (0.6); 7.2718 (0.6); 7.2710 (0.6); 7.2702 (0.7); 7.2694 (0.8); 7.2686 (0.9); 7.2678 (1.1); 7.2670 (1.2); 7.2662 (1.4); 7.2654 (1.7); 7.2645 (2.2); 7.2596 (148.5); 7.2540 (1.8); 7.2532 (1.3); 7.2524 (0.9); 7.2516 (0.6); 6.9955 (1.2); 6.9840 (3.3); 6.9778 (0.6); 6.9739 (0.6); 6.9652 (3.4); 6.9630δ = 7.5185 (0.9); 7.3580 (0.9); 7.3422 (1.5); 7.3366 (1.2); 7.3263 (1.2); 7.3210 (4.2); 7.3164 (3.4); 7.3096 (0.9); 7.3051 (1.2); 7.3002 (1.7); 7.2844 (0.9); 7.2734 (0.5); 7.2726 (0.6); 7.2718 (0.6); 7.2710 (0.6); 7.2702 (0.7); 7.2694 (0.8); 7.2686 (0.9); 7.2678 (1.1); 7.2670 (1.2); 7.2662 (1.4); 7.2654 (1.7); 7.2645 (2.2); 7.2596 (148.5); 7.2540 (1.8); 7.2532 (1.3); 7.2524 (0.9); 7.2516 (0.6); 6.9955 (1.2); 6.9840 (3.3); 6.9778 (0.6); 6.9739 (0.6); 6.9652 (3.4); 6.9630

(3.1) ; 6.9546 (0.6); 6.9444 (2.7); 2.8268 (0.5); 2.7944 (1.0); 2.0292 (1.5); 2.0271 (1.5); 2.0046 (0.8); 1.9938 (14.6); 1.9920 (14.6); 1.8942 (1.8); 1.8830 (1.9); 1.8588 (10.5); 1.8380 (16.0); 1.6922 (0.6); 1.6303 (0.5); 1.5950 (1.2);(3.1); 6.9546 (0.6); 6.9444 (2.7); 2.8268 (0.5); 2.7944 (1.0); 2.0292 (1.5); 2.0271 (1.5); 2.0046 (0.8); 1.9938 (14.6); 1.9920 (14.6); 1.8942 (1.8); 1.8830 (1.9); 1.8588 (10.5); 1.8380 (16.0); 1.6922 (0.6); 1.6303 (0.5); 1.5950 (1.2);

1.5379 (9.2); 1.4276 (0.6); 0.8178 (1.0); 0.0080 (2.0); 0.0057 (0.7); -0.0002 (68.5); -0.0085 (1.9) 1.5379 (9.2); 1.4276 (0.6); 0.8178 (1.0); 0.0080 (2.0); 0.0057 (0.7); -0.0002 (68.5); -0.0085 (1.9)

1.71-282: 1 H-NMR(400.0 MHz, CDCI3):  1.71-282: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.3319 (0.9); 7.3263 (0.7); 7.3172 (2.4); 7.3157 (2.6); 7.3108 (1.9); 7.3057 (0.7); 7.2954 (0.7); 7.2898 (1.0); 7.2740 (0.6); 7.2602 (56.4); 6.9798 (1.9); 6.9784 (1.4); 6.9610 (2.1); 6.9590 (2.0); 6.9402 (1.7); 1.9845 (9.0); 1.9828 (8.9); 1.8312 (1.8); 1.8152 (16.0); 1.5537 (3.5); 1.1319 (1.2); 1.1181 (1.1); 0.9108 (3.4); 0.8942 (3.2); 0.8343 (0.6);δ = 7.3319 (0.9); 7.3263 (0.7); 7.3172 (2.4); 7.3157 (2.6); 7.3108 (1.9); 7.3057 (0.7); 7.2954 (0.7); 7.2898 (1.0); 7.2740 (0.6); 7.2602 (56.4); 6.9798 (1.9); 6.9784 (1.4); 6.9610 (2.1); 6.9590 (2.0); 6.9402 (1.7); 1.9845 (9.0); 1.9828 (8.9); 1.8312 (1.8); 1.8152 (16.0); 1.5537 (3.5); 1.1319 (1.2); 1.1181 (1.1); 0.9108 (3.4); 0.8942 (3.2); 0.8343 (0.6);

0.8181 (0.6); 0.0080 (0.7); -0.0002 (24.2); -0.0085 (0.7) 0.8181 (0.6); 0.0080 (0.7); -0.0002 (24.2); -0.0085 (0.7)

1.71-283: 1 H-NMR(400.0 MHz, CDCI3):  1.71-283: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5190 (0.6); 7.3463 (0.9); 7.3306 (1.7); 7.3254 (1.5); 7.3145 (1.6); 7.3096 (3.6); 7.3046 (1.4); 7.2937 (1.1); 7.2886 (1.5); 7.2724 (0.9); 7.2707 (0.6); 7.2699 (0.6); 7.2691 (0.6); 7.2683 (0.7); 7.2675 (0.8); 7.2667 (0.9); 7.2659 (1.1); 7.2650 (1.3); 7.2642 (1.7); 7.2601 (107.4); 7.2554 (1.8); 7.2537 (1.0); 7.2529 (0.8); 7.2521 (0.5); 6.9961 (0.8); 6.9780 (2.2); 6.9592 (2.9); 6.9394 (1.9); 2.6703 (0.5); 2.6636 (0.6); 2.6365 (1.0); 2.6308 (1.0); 2.5973 (0.5); 1.9842 (16.0); 1.9825 (16.0); 1.8448 (1.8); 1.8327 (15.4); 1.8032 (3.7); 1.5507 (6.3); 1.4210 (0.8); 1.0093 (1.8); 0.9932 (1.8);δ = 7.5190 (0.6); 7.3463 (0.9); 7.3306 (1.7); 7.3254 (1.5); 7.3145 (1.6); 7.3096 (3.6); 7.3046 (1.4); 7.2937 (1.1); 7.2886 (1.5); 7.2724 (0.9); 7.2707 (0.6); 7.2699 (0.6); 7.2691 (0.6); 7.2683 (0.7); 7.2675 (0.8); 7.2667 (0.9); 7.2659 (1.1); 7.2650 (1.3); 7.2642 (1.7); 7.2601 (107.4); 7.2554 (1.8); 7.2537 (1.0); 7.2529 (0.8); 7.2521 (0.5); 6.9961 (0.8); 6.9780 (2.2); 6.9592 (2.9); 6.9394 (1.9); 2.6703 (0.5); 2.6636 (0.6); 2.6365 (1.0); 2.6308 (1.0); 2.5973 (0.5); 1.9842 (16.0); 1.9825 (16.0); 1.8448 (1.8); 1.8327 (15.4); 1.8032 (3.7); 1.5507 (6.3); 1.4210 (0.8); 1.0093 (1.8); 0.9932 (1.8);

0.8647 (1.7); 0.8483 (1.8); 0.8120 (1.0); 0.6541 (0.8); 0.0079 (1.4); -0.0002 (50.0); -0.0085 (1.5) 0.8647 (1.7); 0.8483 (1.8); 0.8120 (1.0); 0.6541 (0.8); 0.0079 (1.4); -0.0002 (50.0); -0.0085 (1.5)

1.71-284: 1 H-NMR(400.0 MHz, CDCI3):  1.71-284: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3586 (2.6); 7.3566 (2.6); 7.3418 (0.6); 7.3207 (1.2); 7.2997 (0.7); 7.2600 (41.2); 6.9828 (1.4); 6.9813 (1.0); 6.9640 (1.6); 6.9619 (1.4); 6.9431 (1.2); 1.9923 (6.5); 1.9906 (6.5); 1.8382 (16.0); 1.5465 (2.4); 0.0080 (0.5); -0.0002δ = 7.3586 (2.6); 7.3566 (2.6); 7.3418 (0.6); 7.3207 (1.2); 7.2997 (0.7); 7.2600 (41.2); 6.9828 (1.4); 6.9813 (1.0); 6.9640 (1.6); 6.9619 (1.4); 6.9431 (1.2); 1.9923 (6.5); 1.9906 (6.5); 1.8382 (16.0); 1.5465 (2.4); 0.0080 (0.5); -0.0002

(18.3); -0.0085 (0.5) (18.3); -0.0085 (0.5)

1.71-285: 1 H-NMR(400.0 MHz, CDCI3):  1.71-285: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3327 (0.7); 7.3283 (2.6); 7.3264 (2.5); 7.3117 (1.0); 7.2906 (0.6); 7.2642 (0.6); 7.2601 (36.7); 6.9793 (1.2); 6.9777 (0.8); 6.9622 (0.9); 6.9605 (1.3); 6.9584 (1.2); 6.9424 (0.5); 6.9397 (1.0); 2.5660 (0.7); 2.5606 (0.7); 1.9868 (5.6); 1.9850 (5.6); 1.8259 (16.0); 1.5513 (2.0); 1.2105 (1.0); 1.1926 (1.0); 1.1753 (0.6); 0.8546 (2.1); 0.8364 (4.4); 0.8181 (1.6); -0.0002 (16.4); -0.0027 (0.8) 1.71-286: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3327 (0.7); 7.3283 (2.6); 7.3264 (2.5); 7.3117 (1.0); 7.2906 (0.6); 7.2642 (0.6); 7.2601 (36.7); 6.9793 (1.2); 6.9777 (0.8); 6.9622 (0.9); 6.9605 (1.3); 6.9584 (1.2); 6.9424 (0.5); 6.9397 (1.0); 2.5660 (0.7); 2.5606 (0.7); 1.9868 (5.6); 1.9850 (5.6); 1.8259 (16.0); 1.5513 (2.0); 1.2105 (1.0); 1.1926 (1.0); 1.1753 (0.6); 0.8546 (2.1); 0.8364 (4.4); 0.8181 (1.6); -0.0002 (16.4); -0.0027 (0.8) 1.71-286: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3366 (3.0); 7.3345 (3.2); 7.3288 (0.6); 7.3126 (1.3); 7.2963 (0.5); 7.2915 (0.9); 7.2651 (0.5); 7.2643 (0.7); 7.2602 (44.4); 6.9810 (1.6); 6.9795 (1.2); 6.9639 (1.2); 6.9622 (1.8); 6.9601 (1.6); 6.9414 (1.4); 2.5816 (0.8); 2.5746 (0.9); 2.5508 (1.1); 2.5481 (1.1); 2.5438 (1.1); 2.5412 (1.1); 2.5173 (0.9); 2.5103 (0.8); 1.9925 (7.4); 1.9908 (7.5); 1.8309 (16.0); 1.5522 (3.0); 0.4489 (0.5); 0.3746 (1.5); 0.3567 (1.2); 0.3529 (0.7); 0.0248 (1.4); 0.0128 (1.3); 0.0080δ = 7.3366 (3.0); 7.3345 (3.2); 7.3288 (0.6); 7.3126 (1.3); 7.2963 (0.5); 7.2915 (0.9); 7.2651 (0.5); 7.2643 (0.7); 7.2602 (44.4); 6.9810 (1.6); 6.9795 (1.2); 6.9639 (1.2); 6.9622 (1.8); 6.9601 (1.6); 6.9414 (1.4); 2.5816 (0.8); 2.5746 (0.9); 2.5508 (1.1); 2.5481 (1.1); 2.5438 (1.1); 2.5412 (1.1); 2.5173 (0.9); 2.5103 (0.8); 1.9925 (7.4); 1.9908 (7.5); 1.8309 (16.0); 1.5522 (3.0); 0.4489 (0.5); 0.3746 (1.5); 0.3567 (1.2); 0.3529 (0.7); 0.0248 (1.4); 0.0128 (1.3); 0.0080

(0.9); -0.0002 (19.7); -0.0051 (0.5); -0.0085 (0.7) (0.9); -0.0002 (19.7); -0.0051 (0.5); -0.0085 (0.7)

1.71-287: 1 H-NMR(400.0 MHz, CDCI3):  1.71-287: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5182 (1.1); 7.3409 (0.6); 7.3360 (2.2); 7.3340 (2.0); 7.3199 (0.8); 7.2989 (0.6); 7.2593 (190.6); 6.9953 (1.2); 6.9824 (1.1); 6.9635 (1.2); 6.9615 (1.1); 6.9427 (0.9); 4.7230 (0.9); 4.7078 (1.1); 4.7033 (1.0); 4.6881 (1.0); 4.4137 (0.6); 4.3987 (1.0); 4.3833 (0.5); 2.6409 (0.6); 2.6045 (0.6); 1.9872 (4.8); 1.9856 (4.9); 1.8238 (16.0); 1.7558 (0.5);δ = 7.5182 (1.1); 7.3409 (0.6); 7.3360 (2.2); 7.3340 (2.0); 7.3199 (0.8); 7.2989 (0.6); 7.2593 (190.6); 6.9953 (1.2); 6.9824 (1.1); 6.9635 (1.2); 6.9615 (1.1); 6.9427 (0.9); 4.7230 (0.9); 4.7078 (1.1); 4.7033 (1.0); 4.6881 (1.0); 4.4137 (0.6); 4.3987 (1.0); 4.3833 (0.5); 2.6409 (0.6); 2.6045 (0.6); 1.9872 (4.8); 1.9856 (4.9); 1.8238 (16.0); 1.7558 (0.5);

1.5471 (3.0); 0.0080 (2.3); -0.0002 (83.2); -0.0085 (2.4) 1.5471 (3.0); 0.0080 (2.3); -0.0002 (83.2); -0.0085 (2.4)

1.71-288: 1 H-NMR(400.0 MHz, CDCI3):  1.71-288: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3658 (0.7); 7.3618 (4.1); 7.3597 (4.2); 7.3500 (1.1); 7.3446 (0.8); 7.3341 (0.6); 7.3290 (1.8); 7.3238 (0.6); 7.3134 (0.7); 7.3127 (0.7); 7.3079 (1.2); 7.2920 (0.5); 7.2665 (0.6); 7.2657 (0.7); 7.2649 (0.8); 7.2641 (1.1); 7.2600 (77.6); 6.9960 (0.6); 6.9883 (2.3); 6.9693 (2.5); 6.9673 (2.3); 6.9485 (2.0); 5.2985 (2.8); 2.9381 (0.8); 1.9983 (10.3);δ = 7.3658 (0.7); 7.3618 (4.1); 7.3597 (4.2); 7.3500 (1.1); 7.3446 (0.8); 7.3341 (0.6); 7.3290 (1.8); 7.3238 (0.6); 7.3134 (0.7); 7.3127 (0.7); 7.3079 (1.2); 7.2920 (0.5); 7.2665 (0.6); 7.2657 (0.7); 7.2649 (0.8); 7.2641 (1.1); 7.2600 (77.6); 6.9960 (0.6); 6.9883 (2.3); 6.9693 (2.5); 6.9673 (2.3); 6.9485 (2.0); 5.2985 (2.8); 2.9381 (0.8); 1.9983 (10.3);

1.9965 (10.4); 1.8316 (10.3); 1.5566 (1.5); 1.3149 (16.0); 0.0080 (0.9); -0.0002 (34.3); -0.0085 (1.1) 1.9965 (10.4); 1.8316 (10.3); 1.5566 (1.5); 1.3149 (16.0); 0.0080 (0.9); -0.0002 (34.3); -0.0085 (1.1)

1.71-289: 1 H-NMR(400.0 MHz, CDCI3):  1.71-289: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5187 (0.8); 7.3568 (3.7); 7.3408 (2.0); 7.3356 (1.6); 7.3250 (1.1); 7.3198 (3.4); 7.3147 (1.2); 7.3038 (1.4); 7.2988 (2.1); 7.2830 (1.1); 7.2719 (0.5); 7.2712 (0.6); 7.2704 (0.7); 7.2696 (0.7); 7.2688 (0.8); 7.2680 (1.0); 7.2672 (1.0); 7.2664 (1.2); 7.2655 (1.4); 7.2647 (1.8); 7.2639 (2.3); 7.2631 (3.2); 7.2598 (141.2); 7.2550 (2.3); 7.2542 (1.8); 7.2534 (1.4); 7.2526 (1.0); 7.2518 (0.6); 6.9958 (1.1); 6.9942 (0.7); 6.9835 (4.3); 6.9773 (0.9); 6.9734 (0.8); 6.9645 (4.9); 6.9626 (4.5); 6.9541 (0.8); 6.9437 (3.7); 6.9327 (0.5); 5.2983 (1.5); 3.6579 (0.5); 2.9782 (0.8); 2.0044 (0.7); 1.9916 (16.0); 1.8578 (6.3); 1.8286 (2.4); 1.7949 (6.0); 1.5681 (2.4); 0.0079 (1.9); 0.0064 (0.5); 0.0055 (0.6); 0.0047δ = 7.5187 (0.8); 7.3568 (3.7); 7.3408 (2.0); 7.3356 (1.6); 7.3250 (1.1); 7.3198 (3.4); 7.3147 (1.2); 7.3038 (1.4); 7.2988 (2.1); 7.2830 (1.1); 7.2719 (0.5); 7.2712 (0.6); 7.2704 (0.7); 7.2696 (0.7); 7.2688 (0.8); 7.2680 (1.0); 7.2672 (1.0); 7.2664 (1.2); 7.2655 (1.4); 7.2647 (1.8); 7.2639 (2.3); 7.2631 (3.2); 7.2598 (141.2); 7.2550 (2.3); 7.2542 (1.8); 7.2534 (1.4); 7.2526 (1.0); 7.2518 (0.6); 6.9958 (1.1); 6.9942 (0.7); 6.9835 (4.3); 6.9773 (0.9); 6.9734 (0.8); 6.9645 (4.9); 6.9626 (4.5); 6.9541 (0.8); 6.9437 (3.7); 6.9327 (0.5); 5.2983 (1.5); 3.6579 (0.5); 2.9782 (0.8); 2.0044 (0.7); 1.9916 (16.0); 1.8578 (6.3); 1.8286 (2.4); 1.7949 (6.0); 1.5681 (2.4); 0.0079 (1.9); 0.0064 (0.5); 0.0055 (0.6); 0.0047

(0.7); 0.0038 (1.0); -0.0002 (60.0); -0.0051 (1.1); -0.0059 (0.9); -0.0068 (0.7); -0.0085 (1.8) (0.7); 0.0038 (1.0); -0.0002 (60.0); -0.0051 (1.1); -0.0059 (0.9); -0.0068 (0.7); -0.0085 (1.8)

1.71-290: 1 H-NMR(400.0 MHz, CDCI3):  1.71-290: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5188 (0.7); 7.4032 (6.1); 7.4012 (6.1); 7.3597 (0.7); 7.3438 (1.4); 7.3386 (1.1); 7.3279 (0.9); 7.3227 (2.8); 7.3176 (0.9); 7.3064 (1.2); 7.3017 (1.8); 7.2858 (0.9); 7.2599 (119.2); 6.9959 (0.9); 6.9836 (3.5); 6.9775 (0.6); 6.9736 (0.6); 6.9649 (3.8); 6.9627 (3.4); 6.9543 (0.6); 6.9440 (3.0); 5.2985 (2.0); 4.5310 (1.1); 3.8904 (0.8); 3.8622 (1.2); 3.7381 (0.9); 3.7115 (0.6); 3.5961 (0.9); 3.5682 (1.1); 3.5273 (1.1); 3.3176 (0.8); 3.2896 (0.7); 2.4416 (0.5); 1.9924 (15.8); 1.9908 (16.0); 1.8762 (6.7); 1.8483 (7.8); 1.6500 (0.5); 1.6182 (0.7); 1.5573 (3.1); 1.5158 (1.2); 0.0080 (1.6); -δ = 7.5188 (0.7); 7.4032 (6.1); 7.4012 (6.1); 7.3597 (0.7); 7.3438 (1.4); 7.3386 (1.1); 7.3279 (0.9); 7.3227 (2.8); 7.3176 (0.9); 7.3064 (1.2); 7.3017 (1.8); 7.2858 (0.9); 7.2599 (119.2); 6.9959 (0.9); 6.9836 (3.5); 6.9775 (0.6); 6.9736 (0.6); 6.9649 (3.8); 6.9627 (3.4); 6.9543 (0.6); 6.9440 (3.0); 5.2985 (2.0); 4.5310 (1.1); 3.8904 (0.8); 3.8622 (1.2); 3.7381 (0.9); 3.7115 (0.6); 3.5961 (0.9); 3.5682 (1.1); 3.5273 (1.1); 3.3176 (0.8); 3.2896 (0.7); 2.4416 (0.5); 1.9924 (15.8); 1.9908 (16.0); 1.8762 (6.7); 1.8483 (7.8); 1.6500 (0.5); 1.6182 (0.7); 1.5573 (3.1); 1.5158 (1.2); 0.0080 (1.6); -

0.0002 (52.4); -0.0085 (1.5) 0.0002 (52.4); -0.0085 (1.5)

1.71-291 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-291: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8128 (3.5); 7.8108 (3.4); 7.5371 (0.8); 7.5321 (0.6); 7.5206 (0.6); 7.5160 (1.4); 7.5114 (0.5); 7.4999 (0.6); 7.4949 (0.9); 7.3491 (0.9); 7.2204 (2.0); 7.2003 (3.1); 7.1860 (1.2); 7.1799 (1.8); 5.7528 (1.5); 3.8208 (0.8); 3.3112 (45.0); 3.1999 (0.5); 3.1703 (0.6); 2.9087 (0.6); 2.9055 (0.6); 2.8876 (0.6); 2.8842 (0.7); 2.8795 (0.6); 2.8760 (0.5); 2.8580 (0.5); 2.8548 (0.5); 2.5234 (1.4); 2.5187 (2.0); 2.5100 (20.4); 2.5054 (42.6); 2.5008 (58.6); 2.4962 (39.9); 2.4916 (17.8); 2.1978 (0.7); 2.1814 (0.8); 2.1742 (1.6); 2.1580 (1.8); 2.1452 (0.9); 1.9268 (8.2); 1.9257 (8.2); 1.7425δ = 7.8128 (3.5); 7.8108 (3.4); 7.5371 (0.8); 7.5321 (0.6); 7.5206 (0.6); 7.5160 (1.4); 7.5114 (0.5); 7.4999 (0.6); 7.4949 (0.9); 7.3491 (0.9); 7.2204 (2.0); 7.2003 (3.1); 7.1860 (1.2); 7.1799 (1.8); 5.7528 (1.5); 3.8208 (0.8); 3.3112 (45.0); 3.1999 (0.5); 3.1703 (0.6); 2.9087 (0.6); 2.9055 (0.6); 2.8876 (0.6); 2.8842 (0.7); 2.8795 (0.6); 2.8760 (0.5); 2.8580 (0.5); 2.8548 (0.5); 2.5234 (1.4); 2.5187 (2.0); 2.5100 (20.4); 2.5054 (42.6); 2,5008 (58.6); 2.4962 (39.9); 2.4916 (17.8); 2.1978 (0.7); 2.1814 (0.8); 2.1742 (1.6); 2.1580 (1.8); 2.1452 (0.9); 1.9268 (8.2); 1.9257 (8.2); 1.7425

(10.6); 1.7279 (1.1); 1.7084 (16.0); 1.6874 (0.9); 1.6798 (0.5) (10.6); 1.7279 (1.1); 1.7084 (16.0); 1.6874 (0.9); 1.6798 (0.5)

1.71-292: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-292: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8093 (6.0); 7.8074 (5.9); 7.5585 (0.8); 7.5418 (1.4); 7.5371 (1.1); 7.5208 (2.4); 7.4997 (2.4); 7.2595 (1.8); 7.2398 (2.1); 7.2281 (3.4); 7.2081 (4.8); 7.1879 (2.7); 3.9613 (0.9); 3.5937 (13.7); 3.0856 (2.7); 2.6759 (1.1); 2.5294δ = 7.8093 (6.0); 7.8074 (5.9); 7.5585 (0.8); 7.5418 (1.4); 7.5371 (1.1); 7.5208 (2.4); 7.4997 (2.4); 7.2595 (1.8); 7.2398 (2.1); 7.2281 (3.4); 7.2081 (4.8); 7.1879 (2.7); 3.9613 (0.9); 3.5937 (13.7); 3.0856 (2.7); 2.6759 (1.1); 2.5294

(4.6) ; 2.5247 (6.3); 2.5160 (63.4); 2.5115 (132.2); 2.5069 (180.8); 2.5023 (123.9); 2.4977 (54.9); 2.3432 (1.3); 2.3331(4.6); 2.5247 (6.3); 2.5160 (63.4); 2.5115 (132.2); 2.5069 (180.8); 2.5023 (123.9); 2.4977 (54.9); 2.3432 (1.3); 2.3331

(1.7) ; 2.3010 (1.3); 2.2894 (1.3); 2.0820 (2.0); 2.0593 (1.9); 2.0392 (1.5); 2.0163 (1.5); 1.9358 (14.8); 1.7473 (1.1);(1.7); 2.3010 (1.3); 2.2894 (1.3); 2.0820 (2.0); 2.0593 (1.9); 2.0392 (1.5); 2.0163 (1.5); 1.9358 (14.8); 1.7473 (1.1);

1.7147 (16.0); 1.7059 (15.8); 1.5777 (0.8); 1.5516 (1.0); 1.2399 (0.7) 1.7147 (16.0); 1.7059 (15.8); 1.5777 (0.8); 1.5516 (1.0); 1.2399 (0.7)

1.71-293: 1 H-NMR(400.0 MHz, CDCI3):  1.71-293: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3425 (2.6); 7.3179 (0.8); 7.3016 (0.6); 7.2969 (0.6); 7.2601 (27.7); 6.9826 (1.3); 6.9638 (1.7); 6.9442 (1.0);δ = 7.3425 (2.6); 7.3179 (0.8); 7.3016 (0.6); 7.2969 (0.6); 7.2601 (27.7); 6.9826 (1.3); 6.9638 (1.7); 6.9442 (1.0);

2.6558 (0.6); 2.0422 (10.4); 1.9931 (6.9); 1.8305 (16.0); 1.5450 (9.2); -0.0002 (13.4) 2.6558 (0.6); 2.0422 (10.4); 1.9931 (6.9); 1.8305 (16.0); 1.5450 (9.2); -0.0002 (13.4)

1.71-295: 1 H-NMR(400.0 MHz, CDCI3):  1.71-295: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3790 (1.8); 7.3773 (1.9); 7.3301 (0.8); 7.2610 (15.7); 6.9868 (1.1); 6.9681 (1.3); 6.9662 (1.2); 6.9475 (1.0); 5.2984 (2.8); 2.7532 (9.5); 2.6656 (0.7); 2.0431 (1.3); 1.9981 (5.7); 1.8401 (16.0); 1.5573 (3.7); 1.2584 (0.7); -0.0002δ = 7.3790 (1.8); 7.3773 (1.9); 7.3301 (0.8); 7.2610 (15.7); 6.9868 (1.1); 6.9681 (1.3); 6.9662 (1.2); 6.9475 (1.0); 5.2984 (2.8); 2.7532 (9.5); 2.6656 (0.7); 2.0431 (1.3); 1.9981 (5.7); 1.8401 (16.0); 1.5573 (3.7); 1.2584 (0.7); -0.0002

(6-7) (6-7)

1.71-296: 1 H-NMR(400.0 MHz, CDCI3):  1.71-296: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5109 (1.7); 7.5089 (1.7); 7.3505 (0.8); 7.3295 (0.5); 7.2604 (14.2); 7.0168 (1.0); 6.9977 (1.1); 6.9960 (1.0); 6.9769 (0.8); 3.8996 (1.3); 3.8934 (1.6); 3.8871 (1.6); 3.8809 (1.3); 2.0305 (4.3); 2.0285 (4.2); 1.8654 (16.0); 1.7820δ = 7.5109 (1.7); 7.5089 (1.7); 7.3505 (0.8); 7.3295 (0.5); 7.2604 (14.2); 7.0168 (1.0); 6.9977 (1.1); 6.9960 (1.0); 6.9769 (0.8); 3.8996 (1.3); 3.8934 (1.6); 3,888 (1.6); 3.8809 (1.3); 2.0305 (4.3); 2.0285 (4.2); 1.8654 (16.0); 1.7820

(2.9); 1.7758 (6.3); 1.7696 (2.9); 1.5584 (2.6); -0.0002 (7.0) (2.9); 1.7758 (6.3); 1.7696 (2.9); 1.5584 (2.6); -0.0002 (7.0)

1.71-297: 1 H-NMR(400.0 MHz, CDCI3):  1.71-297: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3543 (1.6); 7.3524 (1.9); 7.3364 (0.5); 7.3153 (0.9); 7.2943 (0.6); 7.2610 (14.5); 6.9797 (1.1); 6.9782 (0.8); 6.9625 (0.8); 6.9609 (1.2); 6.9588 (1.1); 6.9401 (1.0); 5.2982 (0.5); 2.2047 (1.1); 2.1985 (2.4); 2.1922 (1.0); 1.9961δ = 7.3543 (1.6); 7.3524 (1.9); 7.3364 (0.5); 7.3153 (0.9); 7.2943 (0.6); 7.2610 (14.5); 6.9797 (1.1); 6.9782 (0.8); 6.9625 (0.8); 6.9609 (1.2); 6.9588 (1.1); 6.9401 (1.0); 5.2982 (0.5); 2.2047 (1.1); 2.1985 (2.4); 2.1922 (1.0); 1.9961

(5.0); 1.9943 (5.0); 1.8467 (16.0); 1.5660 (2.3); -0.0002 (7.0) (5.0); 1.9943 (5.0); 1.8467 (16.0); 1.5660 (2.3); -0.0002 (7.0)

1.71-298: 1 H-NMR(400.0 MHz, CDCI3):  1.71-298: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5113 (4.6); 7.5093 (4.5); 7.3893 (0.6); 7.3733 (1.1); 7.3685 (0.8); 7.3678 (0.8); 7.3574 (0.6); 7.3523 (2.1); 7.3472 (0.7); 7.3367 (0.8); 7.3358 (0.8); 7.3312 (1.3); 7.3153 (0.6); 7.2605 (30.7); 7.0229 (2.6); 7.0038 (3.0); 7.0021 (2.7); 6.9967 (0.5); 6.9938 (0.5); 6.9855 (1.2); 6.9830 (2.3); 6.9724 (0.5); 6.9577 (0.5); 6.9398 (0.5); 5.2980 (3.1); 4.6838 (0.7); 4.6780 (0.7); 4.6662 (0.8); 4.6646 (0.8); 4.6605 (0.9); 4.6589 (0.8); 4.6471 (0.7); 4.6414 (0.7); 2.1900δ = 7.5113 (4.6); 7.5093 (4.5); 7.3893 (0.6); 7.3733 (1.1); 7.3685 (0.8); 7.3678 (0.8); 7.3574 (0.6); 7.3523 (2.1); 7.3472 (0.7); 7.3367 (0.8); 7.3358 (0.8); 7.3312 (1.3); 7.3153 (0.6); 7.2605 (30.7); 7.0229 (2.6); 7.0038 (3.0); 7.0021 (2.7); 6.9967 (0.5); 6.9938 (0.5); 6,9855 (1.2); 6.9830 (2.3); 6.9724 (0.5); 6.9577 (0.5); 6.9398 (0.5); 5.2980 (3.1); 4.6838 (0.7); 4.6780 (0.7); 4.6662 (0.8); 4.6646 (0.8); 4.6605 (0.9); 4.6589 (0.8); 4.6471 (0.7); 4.6414 (0.7); 2.1900

(5.6) ; 2.1842 (5.7); 2.0291 (11.5); 2.0270 (11.4); 1.8708 (16.0); 1.8546 (15.9); 1.5593 (7.0); 1.3477 (9.9); 1.3304(5.6); 2.1842 (5.7); 2.0291 (11.5); 2.0270 (11.4); 1.8708 (16.0); 1.8546 (15.9); 1.5593 (7.0); 1.3477 (9.9); 1.3304

(9.7) ; 0.0080 (0.5); -0.0002 (15.8) 1.71-299: 1 H-NMR(400.0 MHz, CDCI3): (9.7); 0.0080 (0.5); -0.0002 (15.8) 1.71-299: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5152 (1.7); 7.5131 (1.7); 7.3484 (0.8); 7.2607 (12.1); 7.0131 (1.0); 6.9940 (1.1); 6.9922 (1.0); 6.9731 (0.8); 5.2981 (3.5); 2.2758 (4.0); 2.0221 (4.3); 2.0201 (4.3); 1.8548 (16.0); 1.5567 (2.8); 1.5372 (13.9); -0.0002 (6.5) 1.71-300: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.5152 (1.7); 7.5131 (1.7); 7.3484 (0.8); 7.2607 (12.1); 7.0131 (1.0); 6.9940 (1.1); 6.9922 (1.0); 6.9731 (0.8); 5.2981 (3.5); 2.2758 (4.0); 2.0221 (4.3); 2.0201 (4.3); 1.8548 (16.0); 1.5567 (2.8); 1.5372 (13.9); -0.0002 (6.5) 1.71-300: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4285 (4.5); 7.3671 (1.0); 7.3512 (2.1); 7.3458 (1.7); 7.3352 (1.2); 7.3301 (4.0); 7.3250 (1.4); 7.3138 (1.7); 7.3090 (2.4); 7.2930 (1.2); 7.2697 (0.6); 7.2689 (0.6); 7.2680 (0.7); 7.2672 (0.8); 7.2664 (1.0); 7.2656 (1.3); 7.2648 (1.7); 7.2614 (68.7); 6.9974 (1.0); 6.9864 (4.1); 6.9763 (0.9); 6.9676 (5.1); 6.9658 (4.8); 6.9573 (0.9); 6.9469 (3.6); 6.9359 (0.5); 5.2984 (16.0); 3.7860 (0.6); 3.7587 (0.6); 2.9889 (1.5); 2.9727 (2.5); 2.9546 (1.9); 2.9369 (1.1); 2.1648 (0.5); 2.1494 (1.1); 2.1332 (2.2); 2.1163 (2.4); 2.0994 (1.6); 2.0067 (14.5); 1.8423 (5.9); 1.8126 (6.5); 1.5697 (15.7);δ = 7.4285 (4.5); 7.3671 (1.0); 7.3512 (2.1); 7.3458 (1.7); 7.3352 (1.2); 7.3301 (4.0); 7.3250 (1.4); 7.3138 (1.7); 7.3090 (2.4); 7.2930 (1.2); 7.2697 (0.6); 7.2689 (0.6); 7.2680 (0.7); 7.2672 (0.8); 7.2664 (1.0); 7.2656 (1.3); 7.2648 (1.7); 7.2614 (68.7); 6.9974 (1.0); 6.9864 (4.1); 6.9763 (0.9); 6.9676 (5.1); 6.9658 (4.8); 6.9573 (0.9); 6.9469 (3.6); 6.9359 (0.5); 5.2984 (16.0); 3.7860 (0.6); 3.7587 (0.6); 2.9889 (1.5); 2.9727 (2.5); 2.9546 (1.9); 2.9369 (1.1); 2.1648 (0.5); 2.1494 (1.1); 2.1332 (2.2); 2.1163 (2.4); 2.0994 (1.6); 2.0067 (14.5); 1.8423 (5.9); 1.8126 (6.5); 1.5697 (15.7);

0.0080 (1.2); 0.0048 (0.6); 0.0040 (0.7); 0.0023 (1.7); -0.0002 (34.9); -0.0050 (0.6); -0.0085 (0.9) 0.0080 (1.2); 0.0048 (0.6); 0.0040 (0.7); 0.0023 (1.7); -0.0002 (34.9); -0.0050 (0.6); -0.0085 (0.9)

1.71-303: 1 H-NMR(400.0 MHz, CDCI3):  1.71-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4347 (1.7); 7.4328 (1.6); 7.2975 (0.8); 7.2765 (0.6); 7.2602 (19.7); 6.9602 (1.0); 6.9412 (1.2); 6.9394 (1.0);δ = 7.4347 (1.7); 7.4328 (1.6); 7.2975 (0.8); 7.2765 (0.6); 7.2602 (19.7); 6.9602 (1.0); 6.9412 (1.2); 6.9394 (1.0);

6.9206 (0.8); 3.1530 (6.9); 3.0057 (3.9); 2.0037 (4.9); 2.0022 (4.5); 1.8295 (16.0); 1.5549 (3.7); -0.0002 (7.2) 6.9206 (0.8); 3.1530 (6.9); 3.0057 (3.9); 2.0037 (4.9); 2.0022 (4.5); 1.8295 (16.0); 1.5549 (3.7); -0.0002 (7.2)

1.71-321 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-321: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4726 (0.9); 7.3377 (0.8); 7.3166 (0.5); 7.2596 (71.6); 7.2099 (0.6); 6.9892 (1.0); 6.9704 (1.2); 6.9683 (1.1); 6.9497 (0.9); 2.6265 (0.8); 2.0108 (4.6); 1.8512 (16.0); 1.2546 (1.7); 0.0079 (0.7); -0.0002 (27.6); -0.0084 (1.3) 1.71-325: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4726 (0.9); 7.3377 (0.8); 7.3166 (0.5); 7.2596 (71.6); 7.2099 (0.6); 6.9892 (1.0); 6.9704 (1.2); 6.9683 (1.1); 6.9497 (0.9); 2.6265 (0.8); 2.0108 (4.6); 1.8512 (16.0); 1.2546 (1.7); 0.0079 (0.7); -0.0002 (27.6); -0.0084 (1.3) 1.71-325: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5393 (1.5); 7.5376 (1.5); 7.2653 (0.5); 7.2645 (0.7); 7.2637 (0.9); 7.2603 (39.4); 7.0104 (0.8); 6.9963 (0.5); 6.9915 (1.0); 6.9711 (0.6); 2.2163 (0.8); 2.1981 (1.4); 2.1792 (0.9); 2.1020 (0.8); 2.0268 (3.6); 1.9142 (16.0); 1.7127 (0.5); 1.6941 (0.9); 1.6755 (0.9); 1.6570 (0.5); 1.5772 (2.2); 0.9768 (1.5); 0.9584 (2.9); 0.9399 (1.3); 0.0080 (0.5);δ = 7.5393 (1.5); 7.5376 (1.5); 7.2653 (0.5); 7.2645 (0.7); 7.2637 (0.9); 7.2603 (39.4); 7.0104 (0.8); 6.9963 (0.5); 6.9915 (1.0); 6.9711 (0.6); 2.2163 (0.8); 2.1981 (1.4); 2.1792 (0.9); 2.1020 (0.8); 2.0268 (3.6); 1.9142 (16.0); 1.7127 (0.5); 1.6941 (0.9); 1.6755 (0.9); 1.6570 (0.5); 1.5772 (2.2); 0.9768 (1.5); 0.9584 (2.9); 0.9399 (1.3); 0.0080 (0.5);

0.0024 (0.7); -0.0002 (17.2) 0.0024 (0.7); -0.0002 (17.2)

1.71-326: 1 H-NMR(400.0 MHz, CDCI3):  1.71-326: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5380 (1.9); 7.5361 (1.9); 7.3353 (0.8); 7.2605 (38.6); 7.0123 (1.1); 6.9934 (1.3); 6.9916 (1.2); 6.9727 (0.9); 3.6520 (1.4); 3.6379 (2.1); 3.6235 (1.5); 3.3983 (10.9); 2.5384 (1.4); 2.5240 (2.0); 2.5099 (1.3); 2.0273 (4.7); 2.0256δ = 7.5380 (1.9); 7.5361 (1.9); 7.3353 (0.8); 7.2605 (38.6); 7.0123 (1.1); 6.9934 (1.3); 6.9916 (1.2); 6.9727 (0.9); 3.6520 (1.4); 3.6379 (2.1); 3.6235 (1.5); 3.3983 (10.9); 2.5384 (1.4); 2.5240 (2.0); 2.5099 (1.3); 2.0273 (4.7); 2.0256

(4.6); 1.9166 (16.0); 1.5725 (5.4); -0.0002 (15.4) (4.6); 1.9166 (16.0); 1.5725 (5.4); -0.0002 (15.4)

1.71-328: 1 H-NMR(400.0 MHz, CDCI3):  1.71-328: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5377 (0.5); 7.5357 (0.5); 7.2602 (15.3); 2.0255 (1.4); 2.0234 (1.4); 1.9170 (4.6); 1.2630 (0.6); 1.2588 (16.0);δ = 7.5377 (0.5); 7.5357 (0.5); 7.2602 (15.3); 2.0255 (1.4); 2.0234 (1.4); 1.9170 (4.6); 1.2630 (0.6); 1.2588 (16.0);

1.2534 (0.5); 1.2351 (10.3); -0.0002 (6.3) 1.2534 (0.5); 1.2351 (10.3); -0.0002 (6.3)

1.71-329: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-329: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8143 (0.7); 7.2107 (0.6); 7.1905 (0.8); 7.1703 (0.5); 3.3242 (16.0); 2.5294 (0.7); 2.5247 (1.0); 2.5160 (9.0); 2.5114 (18.6); 2.5068 (25.3); 2.5022 (17.2); 2.4976 (7.5); 1.9182 (2.4); 1.7400 (4.9); 0.7281 (0.6); 0.7088 (0.9);δ = 7.8143 (0.7); 7.2107 (0.6); 7.1905 (0.8); 7.1703 (0.5); 3.3242 (16.0); 2.5294 (0.7); 2.5247 (1.0); 2.5160 (9.0); 2.5114 (18.6); 2.5068 (25.3); 2.5022 (17.2); 2.4976 (7.5); 1.9182 (2.4); 1.7400 (4.9); 0.7281 (0.6); 0.7088 (0.9);

0.7049 (1.0); 0.6969 (0.6); 0.6930 (0.7) 0.7049 (1.0); 0.6969 (0.6); 0.6930 (0.7)

1.71-332: 1 H-NMR(400.0 MHz, d6-DMSO):  1.71-332: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8192 (1.5); 7.5061 (0.7); 7.2091 (1.0); 7.1890 (1.5); 7.1688 (0.9); 3.3241 (16.0); 2.5159 (8.5); 2.5114 (17.2); 2.5068 (23.0); 2.5022 (16.0); 2.4977 (7.2); 2.0911 (0.9); 1.9202 (4.7); 1.7437 (9.2); 1.7025 (1.5); 1.3613 (0.5); 1.3350δ = 7.8192 (1.5); 7.5061 (0.7); 7.2091 (1.0); 7.1890 (1.5); 7.1688 (0.9); 3.3241 (16.0); 2.5159 (8.5); 2.5114 (17.2); 2.5068 (23.0); 2.5022 (16.0); 2.4977 (7.2); 2.0911 (0.9); 1.9202 (4.7); 1.7437 (9.2); 1.7025 (1.5); 1.3613 (0.5); 1.3350

(0.5); 1.2050 (0.5); 1.1812 (0.6) (0.5); 1.2050 (0.5); 1.1812 (0.6)

1.71-333: 1 H-NMR(400.0 MHz, CDCI3):  1.71-333: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.5685 (1.8); 7.5664 (1.8); 7.4622 (1.2); 7.4602 (1.3); 7.4579 (1.3); 7.4558 (1.2); 7.3387 (0.9); 7.3176 (0.6); 7.2645 (0.5); 7.2604 (28.1); 7.1755 (1.0); 7.1736 (1.0); 7.1667 (1.0); 7.1647 (1.0); 7.0165 (1.2); 6.9974 (1.3); 6.9959 (1.3); 6.9767 (1.0); 6.5084 (1.2); 6.5040 (1.2); 6.4995 (1.2); 6.4951 (1.1); 5.2986 (1.0); 2.0443 (5.1); 2.0424 (4.8);δ = 7.5685 (1.8); 7.5664 (1.8); 7.4622 (1.2); 7.4602 (1.3); 7.4579 (1.3); 7.4558 (1.2); 7.3387 (0.9); 7.3176 (0.6); 7.2645 (0.5); 7.2604 (28.1); 7.1755 (1.0); 7.1736 (1.0); 7.1667 (1.0); 7.1647 (1.0); 7.0165 (1.2); 6.9974 (1.3); 6.9959 (1.3); 6.9767 (1.0); 6.5084 (1.2); 6.5040 (1.2); 6.4995 (1.2); 6.4951 (1.1); 5.2986 (1.0); 2.0443 (5.1); 2.0424 (4.8);

1.9491 (16.0); 1.5611 (4.2); -0.0002 (13.1) 1.9491 (16.0); 1.5611 (4.2); -0.0002 (13.1)

1.71-334: 1 H-NMR(400.0 MHz, CDCI3):  1.71-334: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5897 (1.2); 7.5868 (1.3); 7.5803 (1.3); 7.5774 (1.4); 7.5709 (2.1); 7.5689 (2.1); 7.5100 (1.2); 7.5072 (1.2); 7.4976 (1.3); 7.4947 (1.2); 7.3622 (0.5); 7.3412 (1.0); 7.3201 (0.6); 7.2642 (0.6); 7.2634 (0.8); 7.2601 (35.1); 7.2561 (0.7); 7.2553 (0.5); 7.0754 (1.0); 7.0660 (1.1); 7.0630 (1.0); 7.0536 (1.0); 7.0172 (1.3); 6.9981 (1.4); 6.9962 (1.5); 6.9797 (0.5); 6.9773 (1.1); 5.2984 (1.7); 2.0440 (5.5); 2.0421 (5.1); 1.9433 (16.0); 1.5648 (4.8); 0.0079 (0.5); -0.0002δ = 7.5897 (1.2); 7.5868 (1.3); 7.5803 (1.3); 7.5774 (1.4); 7.5709 (2.1); 7.5689 (2.1); 7.5100 (1.2); 7.5072 (1.2); 7.4976 (1.3); 7.4947 (1.2); 7.3622 (0.5); 7.3412 (1.0); 7.3201 (0.6); 7.2642 (0.6); 7.2634 (0.8); 7.2601 (35.1); 7.2561 (0.7); 7.2553 (0.5); 7.0754 (1.0); 7.0660 (1.1); 7.0630 (1.0); 7.0536 (1.0); 7.0172 (1.3); 6.9981 (1.4); 6.9962 (1.5); 6.9797 (0.5); 6.9773 (1.1); 5.2984 (1.7); 2.0440 (5.5); 2.0421 (5.1); 1.9433 (16.0); 1.5648 (4.8); 0.0079 (0.5); -0.0002

(16-2) (16-2)

1.71-335: 1 H-NMR(400.0 MHz, CDCI3):  1.71-335: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.1447 (0.9); 9.1317 (1.0); 8.4054 (0.9); 8.3944 (0.8); 7.7928 (2.2); 7.7744 (2.3); 7.5760 (2.6); 7.5424 (0.7); 7.5238 (1.7); 7.5189 (1.1); 7.5084 (0.8); 7.5053 (1.3); 7.4494 (2.4); 7.4300 (3.4); 7.4117 (1.4); 7.3795 (0.6); 7.3636 (1.1); 7.3582 (0.9); 7.3477 (0.7); 7.3425 (2.2); 7.3374 (0.8); 7.3263 (0.9); 7.3215 (1.4); 7.3056 (0.7); 7.2706 (0.5); 7.2697 (0.6); 7.2689 (0.7); 7.2682 (0.8); 7.2674 (0.9); 7.2665 (1.0); 7.2657 (1.2); 7.2649 (1.4); 7.2600 (79.0); 7.2552δ = 9.1447 (0.9); 9.1317 (1.0); 8.4054 (0.9); 8.3944 (0.8); 7.7928 (2.2); 7.7744 (2.3); 7.5760 (2.6); 7.5424 (0.7); 7.5238 (1.7); 7.5189 (1.1); 7.5084 (0.8); 7.5053 (1.3); 7.4494 (2.4); 7.4300 (3.4); 7.4117 (1.4); 7.3795 (0.6); 7.3636 (1.1); 7.3582 (0.9); 7.3477 (0.7); 7.3425 (2.2); 7.3374 (0.8); 7.3263 (0.9); 7.3215 (1.4); 7.3056 (0.7); 7.2706 (0.5); 7.2697 (0.6); 7.2689 (0.7); 7.2682 (0.8); 7.2674 (0.9); 7.2665 (1.0); 7.2657 (1.2); 7.2649 (1.4); 7.2600 (79.0); 7.2552

(1.1) ; 7.2544 (0.9); 7.2536 (0.7); 7.2528 (0.6); 7.0225 (2.9); 7.0156 (0.5); 7.0119 (0.6); 7.0036 (3.3); 7.0017 (3.1); 6.9960 (0.8); 6.9937 (0.6); 6.9828 (2.5); 5.2982 (3.2); 2.0507 (12.0); 2.0488 (12.0); 1.9552 (16.0); 1.5641 (12.7);(1.1); 7.2544 (0.9); 7.2536 (0.7); 7.2528 (0.6); 7.0225 (2.9); 7.0156 (0.5); 7.0119 (0.6); 7.0036 (3.3); 7.0017 (3.1); 6.9960 (0.8); 6.9937 (0.6); 6.9828 (2.5); 5.2982 (3.2); 2.0507 (12.0); 2.0488 (12.0); 1.9552 (16.0); 1.5641 (12.7);

1.2583 (0.6); 0.0080 (1.2); -0.0002 (37.3); -0.0085 (1.0) 1.2583 (0.6); 0.0080 (1.2); -0.0002 (37.3); -0.0085 (1.0)

1.71-336: 1 H-NMR(400.0 MHz, CDCI3):  1.71-336: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5660 (0.6); 8.5637 (0.6); 8.5618 (0.7); 8.5595 (0.6); 8.5541 (0.6); 8.5518 (0.7); 8.5499 (0.6); 8.5475 (0.6); 8.1421 (0.6); 8.1395 (0.9); 8.1367 (0.6); 8.1226 (0.7); 8.1200 (1.1); 8.1172 (0.7); 7.8550 (0.7); 7.8507 (0.7); 7.8357δ = 8.5660 (0.6); 8.5637 (0.6); 8.5618 (0.7); 8.5595 (0.6); 8.5541 (0.6); 8.5518 (0.7); 8.5499 (0.6); 8.5475 (0.6); 8.1421 (0.6); 8.1395 (0.9); 8.1367 (0.6); 8.1226 (0.7); 8.1200 (1.1); 8.1172 (0.7); 7.8550 (0.7); 7.8507 (0.7); 7.8357

(1.2) ; 7.8314 (1.1); 7.8163 (0.7); 7.8120 (0.6); 7.5839 (1.8); 7.5819 (1.8); 7.4570 (0.7); 7.4538 (0.7); 7.4450 (0.7); 7.4419 (0.7); 7.4379 (0.6); 7.4347 (0.6); 7.4259 (0.6); 7.4228 (0.6); 7.3371 (0.9); 7.3160 (0.6); 7.2604 (31.7); 7.0184 (1.1); 6.9993 (1.3); 6.9974 (1.2); 6.9786 (1.0); 5.2986 (1.2); 2.0529 (4.6); 2.0509 (4.6); 1.9694 (16.0); 1.5614 (3.2); - 0.0002 (14.4) 1.71-337: 1 H-NMR(400.0 MHz, CDCI3): (1.2); 7.8314 (1.1); 7.8163 (0.7); 7.8120 (0.6); 7.5839 (1.8); 7.5819 (1.8); 7.4570 (0.7); 7.4538 (0.7); 7.4450 (0.7); 7.4419 (0.7); 7.4379 (0.6); 7.4347 (0.6); 7.4259 (0.6); 7.4228 (0.6); 7.3371 (0.9); 7.3160 (0.6); 7.2604 (31.7); 7.0184 (1.1); 6.9993 (1.3); 6.9974 (1.2); 6.9786 (1.0); 5.2986 (1.2); 2.0529 (4.6); 2.0509 (4.6); 1.9694 (16.0); 1.5614 (3.2); - 0.0002 (14.4) 1.71-337: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.2280 (1.2); 9.0175 (1.8); 8.7540 (1.5); 8.7454 (1.5); 8.5559 (0.8); 8.1243 (1.0); 8.1043 (1.0); 7.5761 (2.7); 7.5197 (0.6); 7.4080 (1.0); 7.3953 (1.1); 7.3876 (1.5); 7.3757 (1.0); 7.3716 (1.5); 7.3666 (1.1); 7.3556 (0.8); 7.3505δ = 9.2280 (1.2); 9.0175 (1.8); 8.7540 (1.5); 8.7454 (1.5); 8.5559 (0.8); 8.1243 (1.0); 8.1043 (1.0); 7.5761 (2.7); 7.5197 (0.6); 7.4080 (1.0); 7.3953 (1.1); 7.3876 (1.5); 7.3757 (1.0); 7.3716 (1.5); 7.3666 (1.1); 7.3556 (0.8); 7.3505

(2.3) ; 7.3454 (0.9); 7.3343 (1.0); 7.3295 (1.4); 7.3135 (0.7); 7.2730 (0.5); 7.2722 (0.6); 7.2714 (0.6); 7.2698 (0.8); 7.2690 (0.9); 7.2682 (1.0); 7.2608 (110.1); 7.0374 (0.5); 7.0272 (3.2); 7.0203 (0.6); 7.0165 (0.6); 7.0082 (3.8); 7.0065 (3.5); 6.9968 (1.0); 6.9942 (0.6); 6.9875 (2.8); 5.2987 (2.7); 4.1301 (1.1); 4.1123 (1.1); 2.0520 (12.9); 2.0504 (12.9); 2.0436 (6.3); 1.9534 (16.0); 1.6598 (3.4); 1.2762 (1.7); 1.2583 (3.5); 1.2405 (1.6); 0.0079 (1.6); -0.0002 (50.0); -(2.3); 7.3454 (0.9); 7.3343 (1.0); 7.3295 (1.4); 7.3135 (0.7); 7.2730 (0.5); 7.2722 (0.6); 7.2714 (0.6); 7.2698 (0.8); 7.2690 (0.9); 7.2682 (1.0); 7.2608 (110.1); 7.0374 (0.5); 7.0272 (3.2); 7.0203 (0.6); 7.0165 (0.6); 7.0082 (3.8); 7.0065 (3.5); 6.9968 (1.0); 6.9942 (0.6); 6.9875 (2.8); 5.2987 (2.7); 4.1301 (1.1); 4.1123 (1.1); 2.0520 (12.9); 2.0504 (12.9); 2.0436 (6.3); 1.9534 (16.0); 1.6598 (3.4); 1.2762 (1.7); 1.2583 (3.5); 1.2405 (1.6); 0.0079 (1.6); -0.0002 (50.0); -

0.0085 (1.4) 0.0085 (1.4)

1.71-338: 1 H-NMR(400.0 MHz, CDCI3):  1.71-338: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3031 (0.8); 9.2922 (0.8); 8.7474 (2.3); 8.7325 (2.3); 8.6730 (0.7); 7.6255 (2.3); 7.6105 (2.2); 7.5717 (2.3); 7.3744 (0.6); 7.3693 (0.5); 7.3534 (1.1); 7.3374 (0.6); 7.3325 (0.7); 7.2690 (0.5); 7.2682 (0.6); 7.2674 (0.7); 7.2666 (0.9); 7.2658 (1.0); 7.2649 (1.4); 7.2641 (1.8); 7.2609 (72.4); 7.2568 (1.2); 7.2560 (1.0); 7.2552 (0.7); 7.2544 (0.6); 7.0281 (1.6); 7.0091 (2.1); 6.9968 (0.7); 6.9886 (1.4); 5.2987 (4.0); 2.0502 (7.8); 2.0486 (7.8); 2.0436 (2.8); 1.9472δ = 9.3031 (0.8); 9.2922 (0.8); 8.7474 (2.3); 8.7325 (2.3); 8.6730 (0.7); 7.6255 (2.3); 7.6105 (2.2); 7.5717 (2.3); 7.3744 (0.6); 7.3693 (0.5); 7.3534 (1.1); 7.3374 (0.6); 7.3325 (0.7); 7.2690 (0.5); 7.2682 (0.6); 7.2674 (0.7); 7.2666 (0.9); 7.2658 (1.0); 7.2649 (1.4); 7.2641 (1.8); 7.2609 (72.4); 7.2568 (1.2); 7.2560 (1.0); 7.2552 (0.7); 7.2544 (0.6); 7.0281 (1.6); 7.0091 (2.1); 6.9968 (0.7); 6.9886 (1.4); 5.2987 (4.0); 2.0502 (7.8); 2.0486 (7.8); 2.0436 (2.8); 1.9472

(16.0); 1.6494 (0.9); 1.2762 (0.6); 1.2583 (1.2); 0.0080 (1.0); -0.0002 (32.4); -0.0085 (0.8) (16.0); 1.6494 (0.9); 1.2762 (0.6); 1.2583 (1.2); 0.0080 (1.0); -0.0002 (32.4); -0.0085 (0.8)

1.71-339: 1 H-NMR(400.0 MHz, CDCI3):  1.71-339: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.8760 (4.4); 8.8638 (4.6); 7.5773 (1.8); 7.5752 (1.8); 7.4610 (1.4); 7.4488 (2.6); 7.4366 (1.3); 7.3553 (0.5); 7.3342 (0.9); 7.3132 (0.6); 7.2661 (0.6); 7.2653 (0.8); 7.2612 (38.3); 7.0091 (1.2); 6.9902 (1.3); 6.9882 (1.1); 6.9694 (1.0); 4.1306 (0.7); 4.1127 (0.7); 2.0516 (4.6); 2.0496 (4.6); 2.0441 (3.7); 1.9648 (16.0); 1.5650 (3.9); 1.2766 (1.1);δ = 8.8760 (4.4); 8.8638 (4.6); 7.5773 (1.8); 7.5752 (1.8); 7.4610 (1.4); 7.4488 (2.6); 7.4366 (1.3); 7.3553 (0.5); 7.3342 (0.9); 7.3132 (0.6); 7.2661 (0.6); 7.2653 (0.8); 7.2612 (38.3); 7.0091 (1.2); 6.9902 (1.3); 6.9882 (1.1); 6.9694 (1.0); 4.1306 (0.7); 4.1127 (0.7); 2.0516 (4.6); 2.0496 (4.6); 2.0441 (3.7); 1.9648 (16.0); 1.5650 (3.9); 1.2766 (1.1);

1.2587 (2.2); 1.2409 (1.0); 0.0080 (0.6); -0.0002 (17.8) 1.2587 (2.2); 1.2409 (1.0); 0.0080 (0.6); -0.0002 (17.8)

1.71-370: 1 H-NMR(400.0 MHz, CDCI3):  1.71-370: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5043 (1.8); 7.5023 (1.9); 7.3543 (0.8); 7.3333 (0.6); 7.3240 (1.9); 7.2605 (19.3); 7.0154 (1.0); 6.9961 (1.4); 6.9947 (1.3); 6.9753 (1.0); 4.4325 (1.8); 4.4303 (1.9); 4.4176 (1.8); 4.4154 (1.9); 2.0216 (4.5); 2.0196 (4.7); 1.8673δ = 7.5043 (1.8); 7.5023 (1.9); 7.3543 (0.8); 7.3333 (0.6); 7.3240 (1.9); 7.2605 (19.3); 7.0154 (1.0); 6.9961 (1.4); 6.9947 (1.3); 6.9753 (1.0); 4.4325 (1.8); 4.4303 (1.9); 4.4176 (1.8); 4.4154 (1.9); 2.0216 (4.5); 2.0196 (4.7); 1.8673

(16.0); 1.5741 (1.4); -0.0002 (7.7) (16.0); 1.5741 (1.4); -0.0002 (7.7)

1.71-371 : 1 H-NMR(400.0 MHz, CDCI3):  1.71-371: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5390 (1.8); 7.5371 (1.8); 7.3413 (0.8); 7.3203 (0.5); 7.2605 (16.1); 6.9980 (1.1); 6.9789 (1.3); 6.9582 (1.0); 6.8802 (1.1); 6.8779 (2.0); 4.4437 (1.9); 4.4412 (1.8); 4.4291 (1.9); 4.4265 (1.8); 2.0300 (4.9); 2.0283 (4.8); 1.8935δ = 7.5390 (1.8); 7.5371 (1.8); 7.3413 (0.8); 7.3203 (0.5); 7.2605 (16.1); 6.9980 (1.1); 6.9789 (1.3); 6.9582 (1.0); 6.8802 (1.1); 6.8779 (2.0); 4.4437 (1.9); 4.4412 (1.8); 4.4291 (1.9); 4.4265 (1.8); 2.0300 (4.9); 2.0283 (4.8); 1.8935

(16.0); 1.5832 (1.3); -0.0002 (6.2) (16.0); 1.5832 (1.3); -0.0002 (6.2)

1.71-376: 1 H-NMR(400.0 MHz, CDCI3):  1.71-376: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5030 (4.9); 7.5010 (4.9); 7.4710 (0.9); 7.4518 (0.9); 7.3961 (0.6); 7.3800 (1.2); 7.3745 (0.9); 7.3640 (0.7); 7.3590 (2.2); 7.3540 (0.9); 7.3426 (0.9); 7.3379 (1.5); 7.3219 (0.8); 7.2604 (47.7); 7.0246 (2.9); 7.0175 (0.5); 7.0139 (0.6); 7.0052 (3.4); 7.0038 (3.2); 6.9963 (0.8); 6.9910 (0.6); 6.9844 (2.6); 6.9739 (0.6); 4.9538 (0.8); 4.9361 (1.8); 4.9169 (1.8); 4.8993 (0.8); 3.5372 (0.6); 3.5338 (0.6); 3.5246 (1.4); 3.5204 (1.2); 3.5129 (1.5); 3.5092 (1.8); 3.5049δ = 7.5030 (4.9); 7.5010 (4.9); 7.4710 (0.9); 7.4518 (0.9); 7.3961 (0.6); 7.3800 (1.2); 7.3745 (0.9); 7.3640 (0.7); 7.3590 (2.2); 7.3540 (0.9); 7.3426 (0.9); 7.3379 (1.5); 7.3219 (0.8); 7.2604 (47.7); 7.0246 (2.9); 7.0175 (0.5); 7.0139 (0.6); 7.0052 (3.4); 7.0038 (3.2); 6.9963 (0.8); 6.9910 (0.6); 6.9844 (2.6); 6.9739 (0.6); 4.9538 (0.8); 4.9361 (1.8); 4.9169 (1.8); 4.8993 (0.8); 3.5372 (0.6); 3.5338 (0.6); 3.5246 (1.4); 3.5204 (1.2); 3.5129 (1.5); 3.5092 (1.8); 3.5049

(2.4) ; 3.4978 (2.2); 3.4896 (3.3); 3.4801 (1.4); 3.4743 (2.8); 3.4689 (1.4); 3.4625 (0.7); 3.4591 (1.1); 3.4560 (0.7); 3.4442 (0.6); 2.0266 (12.1); 2.0246 (12.2); 2.0127 (1.6); 2.0009 (1.2); 1.9946 (1.4); 1.9829 (1.4); 1.9783 (1.0); 1.9651 (1.0); 1.9605 (0.9); 1.9492 (0.8); 1.8800 (16.0); 1.8692 (1.4); 1.8522 (16.0); 1.8250 (0.9); 1.5593 (1.1); 1.0893 (12.4);(2.4); 3.4978 (2.2); 3.4896 (3.3); 3.4801 (1.4); 3.4743 (2.8); 3.4689 (1.4); 3.4625 (0.7); 3.4591 (1.1); 3.4560 (0.7); 3.4442 (0.6); 2.0266 (12.1); 2.0246 (12.2); 2.0127 (1.6); 2,0009 (1.2); 1.9946 (1.4); 1.9829 (1.4); 1.9783 (1.0); 1.9651 (1.0); 1.9605 (0.9); 1.9492 (0.8); 1.8800 (16.0); 1.8692 (1.4); 1.8522 (16.0); 1.8250 (0.9); 1.5593 (1.1); 1.0893 (12.4);

1.0867 (12.3); 1.0741 (12.4); 1.0714 (12.2); 1.0233 (0.5); 0.0080 (0.7); -0.0002 (25.3); -0.0085 (0.9) 1.0867 (12.3); 1.0741 (12.4); 1.0714 (12.2); 1.0233 (0.5); 0.0080 (0.7); -0.0002 (25.3); -0.0085 (0.9)

1.71-388: 1 H-NMR(400.0 MHz, CDCI3):  1.71-388: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7668 (1.0); 7.5870 (2.4); 7.5851 (2.4); 7.3374 (0.5); 7.3164 (1.0); 7.2953 (0.6); 7.2601 (37.3); 6.9833 (1.4); 6.9646 (1.7); 6.9627 (1.6); 6.9439 (1.3); 6.5063 (2.2); 5.2981 (1.9); 4.1307 (0.6); 4.1128 (0.6); 2.2747 (7.9); 2.0438δ = 8.7668 (1.0); 7.5870 (2.4); 7.5851 (2.4); 7.3374 (0.5); 7.3164 (1.0); 7.2953 (0.6); 7.2601 (37.3); 6.9833 (1.4); 6.9646 (1.7); 6.9627 (1.6); 6.9439 (1.3); 6.5063 (2.2); 5.2981 (1.9); 4.1307 (0.6); 4.1128 (0.6); 2.2747 (7.9); 2.0438

(3.4) ; 2.0381 (6.2); 2.0368 (6.3); 1.9692 (16.0); 1.2764 (0.8); 1.2585 (1.8); 1.2407 (0.7); -0.0002 (14.8); -0.0085 (0.6)(3.4); 2.0381 (6.2); 2.0368 (6.3); 1.9692 (16.0); 1.2764 (0.8); 1.2585 (1.8); 1.2407 (0.7); -0.0002 (14.8); -0.0085 (0.6)

1.71- 399: 1 H-NMR(400.0 MHz, CDCI3): 1.71-399: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3662 (0.6); 7.5580 (1.0); 7.3639 (0.7); 7.2600 (74.4); 7.0316 (1.6); 7.0123 (2.0); 6.9917 (1.4); 5.2985 (4.1); 2.9347 (3.2); 2.0547 (3.3); 2.0431 (1.1); 1.9416 (3.2); 1.5463 (16.0); 0.0079 (1.3); -0.0002 (37.2); -0.0085 (1.2)δ = 9.3662 (0.6); 7.5580 (1.0); 7.3639 (0.7); 7.2600 (74.4); 7.0316 (1.6); 7.0123 (2.0); 6.9917 (1.4); 5.2985 (4.1); 2.9347 (3.2); 2.0547 (3.3); 2.0431 (1.1); 1.9416 (3.2); 1.5463 (16.0); 0.0079 (1.3); -0.0002 (37.2); -0.0085 (1.2)

1.72- 152: 1 H-NMR(400.0 MHz, CDCI3): 1.72-152: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.4701 (0.7); 7.4656 (0.7); 7.3218 (2.0); 7.3199 (1.8); 7.2594 (46.2); 7.2126 (0.6); 7.2101 (0.7); 7.1939 (0.9); 7.1910 (1.0); 7.1280 (0.5); 2.0677 (3.0); 2.0659 (3.1); 2.0623 (3.2); 2.0605 (3.0); 1.8308 (16.0); 1.5372 (8.8); 0.0079δ = 7.4701 (0.7); 7.4656 (0.7); 7.3218 (2.0); 7.3199 (1.8); 7.2594 (46.2); 7.2126 (0.6); 7.2101 (0.7); 7.1939 (0.9); 7.1910 (1.0); 7.1280 (0.5); 2.0677 (3.0); 2.0659 (3.1); 2.0623 (3.2); 2.0605 (3.0); 1.8308 (16.0); 1.5372 (8.8); 0.0079

(0.8); -0.0002 (26.8); -0.0085 (1.1) (0.8); -0.0002 (26.8); -0.0085 (1.1)

1.72-170: 1 H-NMR(400.0 MHz, CDCI3):  1.72-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5928 (0.7); 7.5883 (0.7); 7.5179 (0.9); 7.4919 (1.7); 7.4900 (1.6); 7.2590 (151.5); 7.2453 (0.7); 7.2422 (0.7); 7.2264 (1.0); 7.2235 (1.1); 7.1518 (0.5); 6.9950 (0.9); 3.9674 (2.7); 3.9541 (2.7); 3.7099 (9.8); 2.1005 (3.0); 2.0987δ = 7.5928 (0.7); 7.5883 (0.7); 7.5179 (0.9); 7.4919 (1.7); 7.4900 (1.6); 7.2590 (151.5); 7.2453 (0.7); 7.2422 (0.7); 7.2264 (1.0); 7.2235 (1.1); 7.1518 (0.5); 6.9950 (0.9); 3.9674 (2.7); 3.9541 (2.7); 3.7099 (9.8); 2.1005 (3.0); 2.0987

(3.0); 2.0950 (3.2); 2.0932 (2.9); 1.8874 (16.0); 1.5390 (1.3); 0.0079 (1.7); -0.0002 (58.7); -0.0085 (1.8) (3.0); 2.0950 (3.2); 2.0932 (2.9); 1.8874 (16.0); 1.5390 (1.3); 0.0079 (1.7); -0.0002 (58.7); -0.0085 (1.8)

1.72-172: 1 H-NMR(400.0 MHz, CDCI3):  1.72-172: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5772 (0.5); 7.5728 (0.5); 7.5586 (1.0); 7.5541 (1.1); 7.5399 (0.6); 7.5353 (0.6); 7.5180 (1.3); 7.4857 (2.3); 7.4838 (2.3); 7.3730 (0.5); 7.3600 (0.6); 7.3523 (0.6); 7.2591 (231.8); 7.2432 (1.0); 7.2401 (1.0); 7.2242 (1.5); 7.2212δ = 7.5772 (0.5); 7.5728 (0.5); 7.5586 (1.0); 7.5541 (1.1); 7.5399 (0.6); 7.5353 (0.6); 7.5180 (1.3); 7.4857 (2.3); 7.4838 (2.3); 7.3730 (0.5); 7.3600 (0.6); 7.3523 (0.6); 7.2591 (231.8); 7.2432 (1.0); 7.2401 (1.0); 7.2242 (1.5); 7.2212

(1.5) ; 7.2053 (0.5); 7.2026 (0.6); 7.1785 (0.7); 7.1756 (0.6); 7.1532 (1.1); 7.1500 (0.9); 7.1322 (0.8); 6.9951 (1.3); 4.4681 (1.0); 4.4501 (1.4); 4.4323 (1.0); 3.6921 (16.0); 2.1002 (4.3); 2.0985 (4.6); 2.0953 (4.6); 2.0937 (4.3); 1.8700(1.5); 7.2053 (0.5); 7.2026 (0.6); 7.1785 (0.7); 7.1756 (0.6); 7.1532 (1.1); 7.1500 (0.9); 7.1322 (0.8); 6.9951 (1.3); 4.4681 (1.0); 4.4501 (1.4); 4.4323 (1.0); 3.6921 (16.0); 2.1002 (4.3); 2.0985 (4.6); 2.0953 (4.6); 2.0937 (4.3); 1.8700

(9.7); 1.8656 (9.7); 1.5296 (12.4); 1.3522 (6.0); 1.3342 (6.0); 0.0080 (2.7); -0.0002 (87.0); -0.0085 (2.3) (9.7); 1.8656 (9.7); 1.5296 (12.4); 1.3522 (6.0); 1.3342 (6.0); 0.0080 (2.7); -0.0002 (87.0); -0.0085 (2.3)

1.72-178: 1 H-NMR(400.0 MHz, CDCI3):  1.72-178: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5180 (1.9); 7.4546 (1.1); 7.3086 (0.7); 7.2591 (332.3); 7.2187 (0.6); 7.1972 (0.6); 6.9951 (1.9); 3.5639 (6.2); 3.4581 (1.1); 3.4425 (1.0); 2.4868 (0.8); 2.4709 (1.4); 2.4553 (0.7); 2.0938 (2.0); 2.0886 (2.0); 1.8500 (9.9); 1.5277δ = 7.5180 (1.9); 7.4546 (1.1); 7.3086 (0.7); 7.2591 (332.3); 7.2187 (0.6); 7.1972 (0.6); 6.9951 (1.9); 3.5639 (6.2); 3.4581 (1.1); 3.4425 (1.0); 2.4868 (0.8); 2.4709 (1.4); 2.4553 (0.7); 2.0938 (2.0); 2.0886 (2.0); 1.8500 (9.9); 1.5277

(16.0); 0.0080 (4.1); -0.0002 (126.7); -0.0085 (3.5) (16.0); 0.0080 (4.1); -0.0002 (126.7); -0.0085 (3.5)

1.72-195: 1 H-NMR(400.0 MHz, CDCI3):  1.72-195: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4798 (1.9); 7.4778 (1.6); 7.4613 (0.6); 7.4567 (0.7); 7.2591 (72.6); 7.2407 (0.6); 7.2378 (0.6); 7.2220 (0.9); 7.2190 (1.0); 3.8619 (1.0); 3.8459 (1.0); 3.8392 (1.0); 3.8232 (1.0); 2.0997 (3.0); 2.0978 (3.2); 2.0952 (3.2); 2.0933 (2.9); 1.8788 (16.0); 1.5301 (7.4); 0.0080 (0.8); -0.0002 (27.3); -0.0085 (0.8) 1.72-310: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4798 (1.9); 7.4778 (1.6); 7.4613 (0.6); 7.4567 (0.7); 7.2591 (72.6); 7.2407 (0.6); 7.2378 (0.6); 7.2220 (0.9); 7.2190 (1.0); 3.8619 (1.0); 3.8459 (1.0); 3.8392 (1.0); 3.8232 (1.0); 2.0997 (3.0); 2.0978 (3.2); 2.0952 (3.2); 2.0933 (2.9); 1.8788 (16.0); 1.5301 (7.4); 0.0080 (0.8); -0.0002 (27.3); -0.0085 (0.8) 1.72-310: 1H-NMR (400.0 MHz, CDCl3):

δ= 7.5039 (0.5); 7.4885 (1.8); 7.4868 (1.8); 7.4403 (0.7); 7.4358 (0.9); 7.3704 (0.5); 7.2602 (23.1); 7.2474 (0.6); 7.2445 (0.7); 7.2286 (1.0); 7.2257 (1.0); 7.2009 (0.5); 7.1752 (0.6); 3.4684 (0.8); 3.4562 (1.0); 3.4437 (0.9); 2.6965δ = 7.5039 (0.5); 7.4885 (1.8); 7.4868 (1.8); 7.4403 (0.7); 7.4358 (0.9); 7.3704 (0.5); 7.2602 (23.1); 7.2474 (0.6); 7.2445 (0.7); 7.2286 (1.0); 7.2257 (1.0); 7.2009 (0.5); 7.1752 (0.6); 3,4684 (0.8); 3.4562 (1.0); 3.4437 (0.9); 2.6965

(1.0) ; 2.6879 (0.8); 2.6839 (1.0); 2.6718 (0.9); 2.5797 (7.0); 2.0972 (4.5); 1.8865 (16.0); -0.0002 (9.4) (1.0); 2.6879 (0.8); 2.6839 (1.0); 2.6718 (0.9); 2.5797 (7.0); 2.0972 (4.5); 1.8865 (16.0); -0.0002 (9.4)

1.72- 353: 1 H-NMR(400.0 MHz, CDCI3):  1.72-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.6128 (0.7); 7.4780 (0.7); 7.4735 (0.8); 7.4651 (1.7); 7.4632 (1.8); 7.2598 (37.6); 7.2503 (0.8); 7.2473 (0.8); 7.2314 (0.9); 7.2284 (1.0); 7.2097 (0.5); 7.1770 (0.5); 4.1304 (0.9); 4.1125 (1.0); 3.9103 (1.3); 3.9020 (0.9); 3.8995 (1.4); 3.8959 (0.8); 3.8923 (0.5); 3.8882 (1.5); 3.6497 (0.6); 3.6402 (0.8); 2.0988 (3.2); 2.0971 (3.6); 2.0945 (3.5); 2.0926 (3.3); 2.0435 (4.2); 1.8896 (16.0); 1.5541 (0.7); 1.2764 (1.2); 1.2586 (2.4); 1.2407 (1.1); -0.0002 (13.3)δ = 9.6128 (0.7); 7.4780 (0.7); 7.4735 (0.8); 7.4651 (1.7); 7.4632 (1.8); 7.2598 (37.6); 7.2503 (0.8); 7.2473 (0.8); 7.2314 (0.9); 7.2284 (1.0); 7.2097 (0.5); 7.1770 (0.5); 4.1304 (0.9); 4.1125 (1.0); 3.9103 (1.3); 3.9020 (0.9); 3.8995 (1.4); 3.8959 (0.8); 3.8923 (0.5); 3.8882 (1.5); 3.6497 (0.6); 3.6402 (0.8); 2.0988 (3.2); 2.0971 (3.6); 2.0945 (3.5); 2.0926 (3.3); 2.0435 (4.2); 1.8896 (16.0); 1.5541 (0.7); 1.2764 (1.2); 1.2586 (2.4); 1.2407 (1.1); -0.0002 (13.3)

1.73- 1 : 1 H-NMR(400.0 MHz, CDCI3): 1.73-1: 1 H NMR (400.0 MHz, CDCl3):

δ= 7.5011 (1.7); 7.4992 (1.6); 7.3410 (0.6); 7.3276 (0.8); 7.3218 (0.9); 7.3192 (1.3); 7.3135 (1.1); 7.3117 (1.9);δ = 7.5011 (1.7); 7.4992 (1.6); 7.3410 (0.6); 7.3276 (0.8); 7.3218 (0.9); 7.3192 (1.3); 7.3135 (1.1); 7.3117 (1.9);

7.2602 (16.2); 7.0994 (0.6); 2.6701 (0.6); 2.6609 (0.6); 1.9704 (5.8); 1.8570 (16.0); 0.6952 (0.8); 0.6915 (1.2); 0.67757.2602 (16.2); 7.0994 (0.6); 2.6701 (0.6); 2.6609 (0.6); 1.9704 (5.8); 1.8570 (16.0); 0.6952 (0.8); 0.6915 (1.2); 0.6775

(1.1) ; 0.6736 (0.9); 0.3847 (0.8); 0.3818 (0.9); 0.3783 (0.9); 0.3760 (0.7); 0.3721 (0.9); 0.3685 (0.8); -0.0002 (6.3) 1.73-1 : 1 H-NMR(400.0 MHz, CDCI3): (1.1); 0.6736 (0.9); 0.3847 (0.8); 0.3818 (0.9); 0.3783 (0.9); 0.3760 (0.7); 0.3721 (0.9); 0.3685 (0.8); -0.0002 (6.3) 1.73-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5013 (1.7); 7.4992 (1.6); 7.4976 (0.6); 7.3413 (0.7); 7.3280 (0.8); 7.3222 (1.0); 7.3193 (1.2); 7.3142 (1.1); 7.3120 (2.1); 7.2641 (0.6); 7.2633 (0.8); 7.2599 (43.1); 7.2552 (0.6); 7.1219 (0.6); 7.1172 (0.5); 7.1027 (0.5); 7.0999 (0.6); 7.0981 (0.5); 2.6698 (0.6); 2.6606 (0.6); 1.9719 (3.6); 1.9704 (5.3); 1.9689 (3.7); 1.8570 (16.0); 1.8498 (0.8); 1.5427 (10.8); 0.6972 (0.5); 0.6953 (0.8); 0.6917 (1.2); 0.6889 (0.6); 0.6791 (0.8); 0.6776 (1.0); 0.6737 (0.9); 0.3847 (0.7); 0.3817 (0.8); 0.3783 (0.8); 0.3756 (0.6); 0.3720 (0.8); 0.3685 (0.8); 0.0080 (0.7); 0.0024 (0.8); -0.0002 (22.2); -δ = 7.5013 (1.7); 7.4992 (1.6); 7.4976 (0.6); 7.3413 (0.7); 7.3280 (0.8); 7.3222 (1.0); 7.3193 (1.2); 7.3142 (1.1); 7.3120 (2.1); 7.2641 (0.6); 7.2633 (0.8); 7.2599 (43.1); 7.2552 (0.6); 7.1219 (0.6); 7.1172 (0.5); 7.1027 (0.5); 7.0999 (0.6); 7.0981 (0.5); 2.6698 (0.6); 2.6606 (0.6); 1.9719 (3.6); 1.9704 (5.3); 1.9689 (3.7); 1.8570 (16.0); 1.8498 (0.8); 1.5427 (10.8); 0.6972 (0.5); 0.6953 (0.8); 0.6917 (1.2); 0.6889 (0.6); 0.6791 (0.8); 0.6776 (1.0); 0.6737 (0.9); 0.3847 (0.7); 0.3817 (0.8); 0.3783 (0.8); 0.3756 (0.6); 0.3720 (0.8); 0.3685 (0.8); 0.0080 (0.7); 0.0024 (0.8); -0.0002 (22.2); -

0.0025 (1.1); -0.0085 (0.6) 0.0025 (1.1); -0.0085 (0.6)

1.73-122: 1 H-NMR(400.0 MHz, CDCI3):  1.73-122: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4326 (1.6); 7.4307 (1.6); 7.2754 (0.7); 7.2598 (23.0); 7.2523 (1.0); 7.2485 (1.8); 7.0462 (0.5); 7.0242 (0.6); 5.2981 (0.9); 3.6928 (0.6); 3.6742 (0.8); 3.6553 (0.6); 3.4745 (0.7); 3.4573 (1.5); 3.4401 (0.8); 2.1419 (0.9); 2.1222δ = 7.4326 (1.6); 7.4307 (1.6); 7.2754 (0.7); 7.2598 (23.0); 7.2523 (1.0); 7.2485 (1.8); 7.0462 (0.5); 7.0242 (0.6); 5.2981 (0.9); 3.6928 (0.6); 3.6742 (0.8); 3.6553 (0.6); 3.4745 (0.7); 3.4573 (1.5); 3,4401 (0.8); 2.1419 (0.9); 2.1222

(0.8); 2.1045 (0.8); 1.9615 (5.4); 1.8623 (16.0); 1.5527 (1.2); -0.0002 (8.6) (0.8); 2.1045 (0.8); 1.9615 (5.4); 1.8623 (16.0); 1.5527 (1.2); -0.0002 (8.6)

1.73-149: 1 H-NMR(400.0 MHz, CDCI3):  1.73-149: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4652 (1.6); 7.4632 (1.6); 7.2771 (0.8); 7.2648 (1.5); 7.2593 (45.8); 7.2516 (1.5); 7.0526 (0.5); 7.0307 (0.6); 5.7407 (0.6); 5.7069 (0.6); 5.2982 (1.7); 4.1952 (0.9); 4.1899 (1.1); 4.1833 (0.8); 3.6489 (0.8); 3.6432 (1.0); 3.6379δ = 7.4652 (1.6); 7.4632 (1.6); 7.2771 (0.8); 7.2648 (1.5); 7.2593 (45.8); 7.2516 (1.5); 7.0526 (0.5); 7.0307 (0.6); 5.7407 (0.6); 5.7069 (0.6); 5.2982 (1.7); 4.1952 (0.9); 4.1899 (1.1); 4.1833 (0.8); 3.6489 (0.8); 3.6432 (1.0); 3.6379

(0.8); 1.9747 (5.4); 1.8625 (16.0); 1.5372 (1.6); 0.0079 (0.5); -0.0002 (16.6) (0.8); 1.9747 (5.4); 1.8625 (16.0); 1.5372 (1.6); 0.0079 (0.5); -0.0002 (16.6)

1.73-167: 1 H-NMR(400.0 MHz, CDCI3):  1.73-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3475 (1.5); 7.3455 (1.5); 7.2985 (0.6); 7.2859 (0.8); 7.2811 (1.8); 7.2757 (0.9); 7.2718 (1.7); 7.2608 (14.5);δ = 7.3475 (1.5); 7.3455 (1.5); 7.2985 (0.6); 7.2859 (0.8); 7.2811 (1.8); 7.2757 (0.9); 7.2718 (1.7); 7.2608 (14.5);

7.0553 (0.5); 1.9548 (4.9); 1.8339 (16.0); -0.0002 (5.3) 7.0553 (0.5); 1.9548 (4.9); 1.8339 (16.0); -0.0002 (5.3)

I.73-303: 1 H-NMR(400.0 MHz, CDCI3):  I.73-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4401 (1.8); 7.4384 (1.8); 7.2817 (1.0); 7.2666 (2.7); 7.2599 (24.2); 7.0311 (0.6); 7.0201 (0.5); 3.1500 (7.0); 3.0431 (4.0); 1.9730 (6.2); 1.8301 (16.0); 1.5468 (3.0); -0.0002 (8.4) δ = 7.4401 (1.8); 7.4384 (1.8); 7.2817 (1.0); 7.2666 (2.7); 7.2599 (24.2); 7.0311 (0.6); 7.0201 (0.5); 3.1500 (7.0); 3.0431 (4.0); 1.9730 (6.2); 1.8301 (16.0); 1.5468 (3.0); -0.0002 (8.4)

1.73- 353: 1 H-NMR(400.0 MHz, CDCI3):  1.73-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.4675 (0.8); 7.5186 (1.9); 7.5173 (1.7); 7.3610 (0.7); 7.3471 (0.7); 7.3413 (0.9); 7.3372 (1.3); 7.3311 (2.0);δ = 9.4675 (0.8); 7.5186 (1.9); 7.5173 (1.7); 7.3610 (0.7); 7.3471 (0.7); 7.3413 (0.9); 7.3372 (1.3); 7.3311 (2.0);

7.2603 (14.2); 7.1148 (0.7); 4.0764 (0.8); 3.8828 (1.3); 3.8720 (1.4); 3.8688 (0.8); 3.8644 (0.5); 3.8607 (1.5); 3.6446 (0.7); 3.6332 (0.8); 3.6278 (0.9); 3.6225 (0.8); 3.6165 (0.7); 3.6057 (0.5); 1.9888 (6.2); 1.9047 (16.0); 1.5655 (2.2); - 0.0002 (6.2) 7.2603 (14.2); 7.1148 (0.7); 4.0764 (0.8); 3.8828 (1.3); 3.8720 (1.4); 3.8688 (0.8); 3.8644 (0.5); 3.8607 (1.5); 3.6446 (0.7); 3.6332 (0.8); 3.6278 (0.9); 3.6225 (0.8); 3.6165 (0.7); 3.6057 (0.5); 1.9888 (6.2); 1.9047 (16.0); 1.5655 (2.2); - 0.0002 (6.2)

1.74- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.74-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5243 (0.7); 8.5127 (0.8); 7.5149 (0.6); 7.5113 (0.7); 7.4896 (0.6); 7.4862 (0.6); 7.4747 (1.4); 7.4730 (1.4); 7.3178 (0.6); 7.3080 (0.6); 7.3063 (0.6); 7.2967 (0.9); 7.2871 (0.5); 7.2854 (0.5); 7.2610 (16.9); 2.6954 (0.6); 2.6859 (0.6); 2.2340 (5.8); 2.2325 (3.8); 1.8494 (16.0); 0.7130 (0.8); 0.7094 (1.2); 0.7067 (0.6); 0.6954 (1.0); 0.6915 (0.9);δ = 8.5243 (0.7); 8.5127 (0.8); 7.5149 (0.6); 7.5113 (0.7); 7.4896 (0.6); 7.4862 (0.6); 7.4747 (1.4); 7.4730 (1.4); 7.3178 (0.6); 7.3080 (0.6); 7.3063 (0.6); 7.2967 (0.9); 7.2871 (0.5); 7.2854 (0.5); 7.2610 (16.9); 2.6954 (0.6); 2.6859 (0.6); 2.2340 (5.8); 2.2325 (3.8); 1.8494 (16.0); 0.7130 (0.8); 0.7094 (1.2); 0.7067 (0.6); 0.6954 (1.0); 0.6915 (0.9);

0.4246 (0.7); 0.4217 (0.8); 0.4180 (0.8); 0.4158 (0.7); 0.4119 (0.8); 0.4083 (0.8); -0.0002 (6.3) 0.4246 (0.7); 0.4217 (0.8); 0.4180 (0.8); 0.4158 (0.7); 0.4119 (0.8); 0.4083 (0.8); -0.0002 (6.3)

1.74-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.74-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5200 (0.8); 8.5084 (0.8); 7.4756 (0.5); 7.4720 (0.9); 7.4509 (0.5); 7.4475 (0.5); 7.3623 (1.4); 7.3603 (1.4); 7.2848 (0.6); 7.2831 (0.6); 7.2735 (0.9); 7.2607 (28.7); 7.2525 (0.6); 3.5308 (0.8); 2.6528 (0.8); 2.1968 (3.1); 2.1948δ = 8.5200 (0.8); 8.5084 (0.8); 7.4756 (0.5); 7.4720 (0.9); 7.4509 (0.5); 7.4475 (0.5); 7.3623 (1.4); 7.3603 (1.4); 7.2848 (0.6); 7.2831 (0.6); 7.2735 (0.9); 7.2607 (28.7); 7.2525 (0.6); 3.5308 (0.8); 2.6528 (0.8); 2.1968 (3.1); 2.1948

(5.2) ; 2.1927 (3.2); 1.8406 (16.0); 1.7269 (1.0); 1.7171 (1.0); 1.7096 (3.0); 1.7021 (1.0); 1.6925 (1.1); 1.5648 (1.6); -(5.2); 2.1927 (3.2); 1.8406 (16.0); 1.7269 (1.0); 1.7171 (1.0); 1.7096 (3.0); 1.7021 (1.0); 1.6925 (1.1); 1.5648 (1.6); -

0.0002 (16.0); -0.0085 (0.5) 0.0002 (16.0); -0.0085 (0.5)

1.74-102: 1 H-NMR(400.0 MHz, CDCI3):  1.74-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5212 (0.5); 8.5176 (0.9); 8.5140 (0.6); 8.5097 (0.6); 8.5060 (0.9); 8.5024 (0.6); 7.4949 (0.5); 7.4916 (0.5); 7.4741 (0.7); 7.4705 (1.1); 7.4669 (0.6); 7.4494 (0.6); 7.4461 (0.6); 7.3371 (1.8); 7.2904 (0.6); 7.2804 (0.9); 7.2693δ = 8.5212 (0.5); 8.5176 (0.9); 8.5140 (0.6); 8.5097 (0.6); 8.5060 (0.9); 8.5024 (0.6); 7.4949 (0.5); 7.4916 (0.5); 7.4741 (0.7); 7.4705 (1.1); 7.4669 (0.6); 7.4494 (0.6); 7.4461 (0.6); 7.3371 (1.8); 7.2904 (0.6); 7.2804 (0.9); 7.2693

(1.3) ; 7.2608 (26.0); 2.7005 (0.5); 2.6885 (0.6); 2.6829 (1.0); 2.6741 (0.7); 2.6708 (0.7); 2.6657 (0.6); 2.6565 (0.6);(1.3); 7.2608 (26.0); 2.7005 (0.5); 2.6885 (0.6); 2.6829 (1.0); 2.6741 (0.7); 2.6708 (0.7); 2.6657 (0.6); 2.6565 (0.6);

2.1998 (6.3); 1.8391 (0.8); 1.8231 (16.0); 1.5660 (5.5); 1.2225 (4.1); 1.2068 (4.0); -0.0002 (11.1) 2.1998 (6.3); 1.8391 (0.8); 1.8231 (16.0); 1.5660 (5.5); 1.2225 (4.1); 1.2068 (4.0); -0.0002 (11.1)

1.74-113: 1 H-NMR(400.0 MHz, CDCI3):  1.74-113: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5294 (1.4); 8.5257 (2.4); 8.5219 (1.5); 8.5179 (1.5); 8.5141 (2.5); 8.5104 (1.4); 7.4969 (1.3); 7.4935 (1.4); 7.4761 (1.7); 7.4724 (2.8); 7.4688 (1.5); 7.4514 (1.6); 7.4480 (1.6); 7.3354 (4.8); 7.3336 (4.8); 7.2951 (1.6); 7.2854 (2.0); 7.2837 (2.0); 7.2740 (3.0); 7.2611 (60.3); 7.2531 (1.6); 3.6959 (0.6); 2.1998 (0.6); 2.1848 (10.0); 2.1828 (16.0); 2.1807 (10.7); 2.0728 (1.0); 1.8683 (4.3); 1.8358 (4.2); 1.8234 (2.5); 1.5698 (8.7); 1.4416 (0.6); 1.3479 (2.2); 1.3337δ = 8.5294 (1.4); 8.5257 (2.4); 8.5219 (1.5); 8.5179 (1.5); 8.5141 (2.5); 8.5104 (1.4); 7.4969 (1.3); 7.4935 (1.4); 7.4761 (1.7); 7.4724 (2.8); 7.4688 (1.5); 7.4514 (1.6); 7.4480 (1.6); 7.3354 (4.8); 7.3336 (4.8); 7.2951 (1.6); 7.2854 (2.0); 7.2837 (2.0); 7.2740 (3.0); 7.2611 (60.3); 7.2531 (1.6); 3.6959 (0.6); 2.1998 (0.6); 2.1848 (10.0); 2.1828 (16.0); 2.1807 (10.7); 2.0728 (1.0); 1.8683 (4.3); 1.8358 (4.2); 1.8234 (2.5); 1.5698 (8.7); 1.4416 (0.6); 1.3479 (2.2); 1.3337

(2.3); 1.2545 (0.6); 0.7150 (2.2); 0.7013 (2.1); 0.0080 (0.9); -0.0002 (26.1); -0.0085 (0.9) (2.3); 1.2545 (0.6); 0.7150 (2.2); 0.7013 (2.1); 0.0080 (0.9); -0.0002 (26.1); -0.0085 (0.9)

1.74-122: 1 H-NMR(400.0 MHz, CDCI3):  1.74-122: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.4925 (0.7); 8.4809 (0.7); 7.4433 (0.5); 7.4396 (0.8); 7.4185 (0.6); 7.4146 (0.8); 7.4117 (1.5); 7.4098 (1.5); 7.2605 (18.7); 7.2547 (0.7); 7.2530 (0.6); 7.2432 (0.8); 3.7207 (0.7); 3.7021 (0.8); 3.6832 (0.7); 3.4800 (0.9); 3.4628 (1.8); 3.4456 (0.9); 2.2019 (5.5); 2.1651 (0.8); 2.1462 (0.9); 2.1279 (0.8); 1.8656 (16.0); -0.0002 (7.1) 1.74-124: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.4925 (0.7); 8.4809 (0.7); 7.4433 (0.5); 7.4396 (0.8); 7.4185 (0.6); 7.4146 (0.8); 7.4117 (1.5); 7.4098 (1.5); 7.2605 (18.7); 7.2547 (0.7); 7.2530 (0.6); 7.2432 (0.8); 3.7207 (0.7); 3.7021 (0.8); 3.6832 (0.7); 3.4800 (0.9); 3.4628 (1.8); 3.4456 (0.9); 2.2019 (5.5); 2.1651 (0.8); 2.1462 (0.9); 2.1279 (0.8); 1.8656 (16.0); -0.0002 (7.1) 1.74-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5288 (0.7); 8.5172 (0.8); 7.4782 (0.5); 7.4745 (0.9); 7.4535 (0.5); 7.4500 (0.5); 7.3095 (1.5); 7.3075 (1.5); 7.2961 (0.6); 7.2863 (0.6); 7.2846 (0.6); 7.2750 (0.9); 7.2652 (0.8); 7.2610 (20.8); 7.2541 (0.5); 5.2985 (1.0); 2.1883δ = 8.5288 (0.7); 8.5172 (0.8); 7.4782 (0.5); 7.4745 (0.9); 7.4535 (0.5); 7.4500 (0.5); 7.3095 (1.5); 7.3075 (1.5); 7.2961 (0.6); 7.2863 (0.6); 7.2846 (0.6); 7.2750 (0.9); 7.2652 (0.8); 7.2610 (20.8); 7.2541 (0.5); 5.2985 (1.0); 2.1883

(3.0) ; 2.1860 (4.5); 2.1836 (3.0); 1.8412 (16.0); 1.5687 (0.8); 1.5227 (0.6); 1.5092 (0.6); -0.0002 (7.7) (3.0); 2.1860 (4.5); 2.1836 (3.0); 1.8412 (16.0); 1.5687 (0.8); 1.5227 (0.6); 1.5092 (0.6); -0.0002 (7.7)

1.74-133: 1 H-NMR(400.0 MHz, CDCI3):  1.74-133: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5274 (0.8); 8.5236 (0.5); 8.5196 (0.5); 8.5158 (0.8); 7.4795 (0.6); 7.4759 (1.0); 7.4722 (0.5); 7.4548 (0.6); 7.4514 (0.6); 7.3113 (1.6); 7.3093 (1.7); 7.2996 (0.6); 7.2897 (0.7); 7.2880 (0.7); 7.2784 (1.0); 7.2689 (0.7); 7.2671 (0.8); 7.2611 (23.0); 3.3012 (0.6); 3.2911 (0.7); 3.2852 (12.9); 2.1842 (3.2); 2.1820 (5.0); 2.1797 (3.6); 1.8415 (16.0);δ = 8.5274 (0.8); 8.5236 (0.5); 8.5196 (0.5); 8.5158 (0.8); 7.4795 (0.6); 7.4759 (1.0); 7.4722 (0.5); 7.4548 (0.6); 7.4514 (0.6); 7.3113 (1.6); 7.3093 (1.7); 7.2996 (0.6); 7.2897 (0.7); 7.2880 (0.7); 7.2784 (1.0); 7.2689 (0.7); 7.2671 (0.8); 7.2611 (23.0); 3.3012 (0.6); 3.2911 (0.7); 3.2852 (12.9); 2.1842 (3.2); 2.1820 (5.0); 2.1797 (3.6); 1.8415 (16.0);

1.5645 (3.6); -0.0002 (10.0) 1.5645 (3.6); -0.0002 (10.0)

1.74-135: 1 H-NMR(400.0 MHz, CDCI3):  1.74-135: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5287 (0.6); 8.5249 (1.1); 8.5212 (0.7); 8.5171 (0.7); 8.5133 (1.1); 8.5096 (0.6); 7.4987 (0.6); 7.4953 (0.6); 7.4779 (0.8); 7.4742 (1.3); 7.4706 (0.7); 7.4532 (0.8); 7.4497 (0.8); 7.3160 (2.1); 7.3141 (2.2); 7.2996 (0.8); 7.2898 (0.9); 7.2881 (0.9); 7.2784 (1.3); 7.2689 (1.0); 7.2671 (1.1); 7.2610 (37.6); 4.1607 (0.5); 4.1428 (0.6); 4.1298 (1.0); 4.1120 (3.2); 4.0941 (3.3); 4.0763 (1.0); 2.3990 (0.6); 2.1913 (4.2); 2.1891 (6.7); 2.1869 (4.6); 2.0907 (1.7); 1.8399 (16.0); 1.5613 (6.8); 1.2786 (0.6); 1.2607 (1.3); 1.2429 (0.8); 1.2388 (3.7); 1.2210 (7.8); 1.2031 (3.6); 0.0079 (0.6); -δ = 8.5287 (0.6); 8.5249 (1.1); 8.5212 (0.7); 8.5171 (0.7); 8.5133 (1.1); 8.5096 (0.6); 7.4987 (0.6); 7.4953 (0.6); 7.4779 (0.8); 7.4742 (1.3); 7.4706 (0.7); 7.4532 (0.8); 7.4497 (0.8); 7.3160 (2.1); 7.3141 (2.2); 7.2996 (0.8); 7.2898 (0.9); 7.2881 (0.9); 7.2784 (1.3); 7.2689 (1.0); 7.2671 (1.1); 7.2610 (37.6); 4.1607 (0.5); 4.1428 (0.6); 4.1298 (1.0); 4.1120 (3.2); 4.0941 (3.3); 4.0763 (1.0); 2.3990 (0.6); 2.1913 (4.2); 2.1891 (6.7); 2.1869 (4.6); 2.0907 (1.7); 1.8399 (16.0); 1.5613 (6.8); 1.2786 (0.6); 1.2607 (1.3); 1.2429 (0.8); 1.2388 (3.7); 1.2210 (7.8); 1.2031 (3.6); 0.0079 (0.6); -

0.0002 (16.6); -0.0085 (0.5) 0.0002 (16.6); -0.0085 (0.5)

1.74-149: 1 H-NMR(400.0 MHz, CDCI3):  1.74-149: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5085 (0.8); 8.4968 (0.8); 7.4587 (0.5); 7.4552 (0.9); 7.4425 (1.5); 7.4406 (1.5); 7.4343 (0.5); 7.2803 (0.6); 7.2705 (0.9); 7.2686 (1.0); 7.2594 (81.7); 7.2497 (0.6); 7.2480 (0.5); 5.7460 (0.6); 5.7040 (0.6); 4.1931 (0.9); 4.1876δ = 8.5085 (0.8); 8.4968 (0.8); 7.4587 (0.5); 7.4552 (0.9); 7.4425 (1.5); 7.4406 (1.5); 7.4343 (0.5); 7.2803 (0.6); 7.2705 (0.9); 7.2686 (1.0); 7.2594 (81.7); 7.2497 (0.6); 7.2480 (0.5); 5.7460 (0.6); 5.7040 (0.6); 4.1931 (0.9); 4.1876

(1.1) ; 4.1808 (0.9); 3.6466 (0.8); 3.6407 (1.0); 3.6353 (0.8); 2.1967 (3.3); 2.1946 (5.5); 2.1926 (3.3); 1.8806 (16.0);(1.1); 4.1808 (0.9); 3.6466 (0.8); 3.6407 (1.0); 3.6353 (0.8); 2.1967 (3.3); 2.1946 (5.5); 2.1926 (3.3); 1.8806 (16.0);

0.0080 (1.0); -0.0002 (30.4); -0.0085 (0.8) 0.0080 (1.0); -0.0002 (30.4); -0.0085 (0.8)

1.74-149: 1 H-NMR(400.0 MHz, CDCI3):  1.74-149: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5103 (0.5); 8.5066 (0.8); 8.5028 (0.5); 8.4987 (0.5); 8.4950 (0.8); 7.4573 (0.6); 7.4538 (1.0); 7.4503 (0.6); 7.4436 (1.8); 7.4420 (1.7); 7.4329 (0.6); 7.4295 (0.5); 7.2797 (0.6); 7.2681 (1.1); 7.2610 (21.9); 7.2490 (0.6); 5.7446 (0.6); 5.7026 (0.7); 4.1923 (1.1); 4.1866 (1.4); 4.1802 (1.1); 3.6459 (1.0); 3.6402 (1.3); 3.6348 (1.0); 2.1938 (6.0);δ = 8.5103 (0.5); 8.5066 (0.8); 8.5028 (0.5); 8.4987 (0.5); 8.4950 (0.8); 7.4573 (0.6); 7.4538 (1.0); 7.4503 (0.6); 7.4436 (1.8); 7.4420 (1.7); 7.4329 (0.6); 7.4295 (0.5); 7.2797 (0.6); 7.2681 (1.1); 7.2610 (21.9); 7.2490 (0.6); 5.7446 (0.6); 5.7026 (0.7); 4.1923 (1.1); 4.1866 (1.4); 4.1802 (1.1); 3.6459 (1.0); 3.6402 (1.3); 3.6348 (1.0); 2.1938 (6.0);

1.8943 (0.8); 1.8802 (16.0); 1.8684 (1.0); 1.5795 (3.0); -0.0002 (8.4) 1.8943 (0.8); 1.8802 (16.0); 1.8684 (1.0); 1.5795 (3.0); -0.0002 (8.4)

1.74-150: 1 H-NMR(400.0 MHz, CDCI3):  1.74-150: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5029 (0.8); 8.4913 (0.8); 7.4550 (0.6); 7.4514 (0.9); 7.4304 (0.6); 7.4269 (0.6); 7.4173 (1.6); 7.4155 (1.7); 7.2726 (0.7); 7.2607 (21.3); 7.2515 (1.0); 7.2403 (0.5); 3.7646 (0.6); 3.7513 (0.9); 3.7371 (0.6); 3.2461 (0.7); 3.2329δ = 8.5029 (0.8); 8.4913 (0.8); 7.4550 (0.6); 7.4514 (0.9); 7.4304 (0.6); 7.4269 (0.6); 7.4173 (1.6); 7.4155 (1.7); 7.2726 (0.7); 7.2607 (21.3); 7.2515 (1.0); 7.2403 (0.5); 3.7646 (0.6); 3.7513 (0.9); 3.7371 (0.6); 3.2461 (0.7); 3.2329

(1.0) ; 3.2205 (0.6); 2.1987 (6.0); 1.8445 (16.0); 1.6625 (0.7); 1.6484 (0.6); 1.6083 (0.6); 1.6002 (0.5); 1.5949 (0.7);(1.0); 3.2205 (0.6); 2.1987 (6.0); 1.8445 (16.0); 1.6625 (0.7); 1.6484 (0.6); 1.6083 (0.6); 1.6002 (0.5); 1.5949 (0.7);

1.5739 (3.1); -0.0002 (9.2) 1.5739 (3.1); -0.0002 (9.2)

1.74-152: 1 H-NMR(400.0 MHz, CDCI3):  1.74-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5266 (0.8); 8.5150 (0.8); 7.4856 (0.5); 7.4820 (0.9); 7.4609 (0.5); 7.4575 (0.5); 7.3502 (1.5); 7.3485 (1.6); 7.2994 (0.6); 7.2980 (0.6); 7.2882 (0.9); 7.2771 (0.5); 7.2670 (0.6); 7.2611 (17.8); 5.2986 (1.4); 2.1959 (5.2); 1.8488δ = 8.5266 (0.8); 8.5150 (0.8); 7.4856 (0.5); 7.4820 (0.9); 7.4609 (0.5); 7.4575 (0.5); 7.3502 (1.5); 7.3485 (1.6); 7.2994 (0.6); 7.2980 (0.6); 7.2882 (0.9); 7.2771 (0.5); 7.2670 (0.6); 7.2611 (17.8); 5.2986 (1.4); 2.1959 (5.2); 1.8488

(16.0); 1.5671 (0.9); -0.0002 (6.6) (16.0); 1.5671 (0.9); -0.0002 (6.6)

1.74-156: 1 H-NMR(400.0 MHz, CDCI3):  1.74-156: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5314 (1.2); 8.5276 (2.1); 8.5239 (1.4); 8.5199 (1.4); 8.5160 (2.2); 8.5123 (1.3); 7.5077 (1.2); 7.5043 (1.2); 7.4868 (1.5); 7.4832 (2.4); 7.4796 (1.3); 7.4621 (1.4); 7.4587 (1.4); 7.3460 (3.7); 7.3446 (3.8); 7.3099 (1.5); 7.3000 (1.8); 7.2984 (1.8); 7.2887 (2.5); 7.2791 (1.5); 7.2775 (1.6); 7.2675 (1.8); 7.2609 (62.7); 2.8007 (0.6); 2.4987 (0.8); 2.4723 (0.9); 2.4654 (0.9); 2.4391 (0.7); 2.1930 (9.0); 2.1908 (14.4); 2.1887 (9.9); 1.8576 (11.1); 1.8404 (16.0);δ = 8.5314 (1.2); 8.5276 (2.1); 8.5239 (1.4); 8.5199 (1.4); 8.5160 (2.2); 8.5123 (1.3); 7.5077 (1.2); 7.5043 (1.2); 7.4868 (1.5); 7.4832 (2.4); 7.4796 (1.3); 7.4621 (1.4); 7.4587 (1.4); 7.3460 (3.7); 7.3446 (3.8); 7.3099 (1.5); 7.3000 (1.8); 7.2984 (1.8); 7.2887 (2.5); 7.2791 (1.5); 7.2775 (1.6); 7.2675 (1.8); 7.2609 (62.7); 2.8007 (0.6); 2.4987 (0.8); 2.4723 (0.9); 2.4654 (0.9); 2.4391 (0.7); 2.1930 (9.0); 2.1908 (14.4); 2.1887 (9.9); 1.8576 (11.1); 1.8404 (16.0);

1.5585 (15.1); 0.0080 (0.9); -0.0002 (28.0); -0.0085 (0.9) 1.5585 (15.1); 0.0080 (0.9); -0.0002 (28.0); -0.0085 (0.9)

1.74-167: 1 H-NMR(400.0 MHz, CDCI3):  1.74-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5253 (0.7); 8.5137 (0.7); 7.4802 (0.5); 7.4765 (0.8); 7.3181 (1.4); 7.3161 (1.4); 7.2885 (0.6); 7.2869 (0.6); 7.2772 (0.8); 7.2676 (0.6); 7.2625 (12.4); 7.2563 (0.5); 2.1938 (3.0); 2.1917 (4.7); 2.1895 (3.0); 1.8683 (0.5); 1.8493δ = 8.5253 (0.7); 8.5137 (0.7); 7.4802 (0.5); 7.4765 (0.8); 7.3181 (1.4); 7.3161 (1.4); 7.2885 (0.6); 7.2869 (0.6); 7.2772 (0.8); 7.2676 (0.6); 7.2625 (12.4); 7.2563 (0.5); 2.1938 (3.0); 2.1917 (4.7); 2.1895 (3.0); 1.8683 (0.5); 1.8493

(16.0); 1.6044 (0.7); -0.0002 (4.5) (16.0); 1.6044 (0.7); -0.0002 (4.5)

1.74-17: 1 H-NMR(400.0 MHz, CDCI3):  1.74-17: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5228 (0.8); 8.5190 (1.3); 8.5152 (0.8); 8.5112 (0.8); 8.5074 (1.4); 8.5037 (0.8); 7.5023 (0.7); 7.4988 (0.7); 7.4814 (0.9); 7.4779 (1.4); 7.4743 (0.8); 7.4568 (0.8); 7.4534 (0.8); 7.3778 (0.9); 7.3056 (0.9); 7.2957 (1.0); 7.2941δ = 8.5228 (0.8); 8.5190 (1.3); 8.5152 (0.8); 8.5112 (0.8); 8.5074 (1.4); 8.5037 (0.8); 7.5023 (0.7); 7.4988 (0.7); 7.4814 (0.9); 7.4779 (1.4); 7.4743 (0.8); 7.4568 (0.8); 7.4534 (0.8); 7.3778 (0.9); 7.3056 (0.9); 7.2957 (1.0); 7.2941

(1.1) ; 7.2845 (1.5); 7.2749 (0.9); 7.2733 (1.0); 7.2614 (29.3); 2.1928 (5.3); 1.8509 (0.6); 1.8356 (16.0); 1.8129 (0.7);(1.1); 7.2845 (1.5); 7.2749 (0.9); 7.2733 (1.0); 7.2614 (29.3); 2.1928 (5.3); 1.8509 (0.6); 1.8356 (16.0); 1.8129 (0.7);

1.5772 (4.0); -0.0002 (12.9) 1.5772 (4.0); -0.0002 (12.9)

1.74-170: 1 H-NMR(400.0 MHz, CDCI3):  1.74-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5030 (0.8); 8.4914 (0.8); 7.5373 (0.5); 7.5295 (1.6); 7.5276 (1.6); 7.5199 (0.7); 7.5162 (0.9); 7.4950 (0.6); 7.4916 (0.6); 7.3251 (0.6); 7.3153 (0.6); 7.3136 (0.6); 7.3039 (0.9); 7.2944 (0.5); 7.2927 (0.5); 7.2610 (21.1); 5.2983δ = 8.5030 (0.8); 8.4914 (0.8); 7.5373 (0.5); 7.5295 (1.6); 7.5276 (1.6); 7.5199 (0.7); 7.5162 (0.9); 7.4950 (0.6); 7.4916 (0.6); 7.3251 (0.6); 7.3153 (0.6); 7.3136 (0.6); 7.3039 (0.9); 7.2944 (0.5); 7.2927 (0.5); 7.2610 (21.1); 5.2983

(1.8) ; 3.9556 (2.6); 3.9415 (2.6); 3.6852 (10.5); 2.2215 (3.2); 2.2192 (5.3); 2.2170 (3.3); 1.9085 (16.0); -0.0002 (8.0) 1.74-171 : 1 H-NMR(400.0 MHz, CDCI3): (1.8); 3.9556 (2.6); 3.9415 (2.6); 3.6852 (10.5); 2.2215 (3.2); 2.2192 (5.3); 2.2170 (3.3); 1.9085 (16.0); -0.0002 (8.0) 1.74-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6970 (1.0); 8.6846 (1.0); 7.6619 (0.9); 7.6402 (0.6); 7.5189 (0.7); 7.5077 (1.7); 7.4623 (0.7); 7.4517 (0.7); 7.4415 (0.6); 7.2600 (97.2); 6.9960 (0.6); 4.0732 (3.7); 3.7620 (6.2); 2.5888 (6.0); 2.1781 (4.6); 1.8713 (16.0); 0.0079δ = 8.6970 (1.0); 8.6846 (1.0); 7.6619 (0.9); 7.6402 (0.6); 7.5189 (0.7); 7.5077 (1.7); 7.4623 (0.7); 7.4517 (0.7); 7.4415 (0.6); 7.2600 (97.2); 6.9960 (0.6); 4.0732 (3.7); 3.7620 (6.2); 2.5888 (6.0); 2.1781 (4.6); 1.8713 (16.0); 0.0079

(1.0); -0.0002 (36.8); -0.0085 (1.2) (1.0); -0.0002 (36.8); -0.0085 (1.2)

1.74-178: 1 H-NMR(400.0 MHz, CDCI3):  1.74-178: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.4943 (0.8); 8.4827 (0.8); 7.5250 (0.5); 7.5213 (0.8); 7.5178 (0.5); 7.5001 (0.5); 7.4966 (0.5); 7.4810 (1.6); 7.4792 (1.6); 7.3267 (0.5); 7.3167 (0.6); 7.3152 (0.6); 7.3054 (0.8); 7.2957 (0.5); 7.2942 (0.5); 7.2600 (37.5); 3.5641 (10.4); 3.4717 (0.7); 3.4555 (1.7); 3.4401 (1.7); 3.4239 (0.7); 2.4948 (1.3); 2.4785 (2.6); 2.4621 (1.2); 2.2069 (5.4);δ = 8.4943 (0.8); 8.4827 (0.8); 7.5250 (0.5); 7.5213 (0.8); 7.5178 (0.5); 7,5001 (0.5); 7.4966 (0.5); 7.4810 (1.6); 7.4792 (1.6); 7.3267 (0.5); 7.3167 (0.6); 7.3152 (0.6); 7.3054 (0.8); 7.2957 (0.5); 7.2942 (0.5); 7.2600 (37.5); 3.5641 (10.4); 3.4717 (0.7); 3.4555 (1.7); 3.4401 (1.7); 3.4239 (0.7); 2.4948 (1.3); 2.4785 (2.6); 2.4621 (1.2); 2.2069 (5.4);

1.8649 (16.0); -0.0002 (13.8) 1.8649 (16.0); -0.0002 (13.8)

1.74-179: 1 H-NMR(400.0 MHz, CDCI3):  1.74-179: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6779 (1.2); 8.6658 (1.2); 7.6445 (0.8); 7.4465 (0.7); 7.4361 (0.7); 7.4256 (0.6); 7.3451 (1.8); 7.2614 (40.3); 4.1353 (0.6); 4.1187 (0.7); 3.6324 (0.6); 2.5997 (0.7); 2.5185 (1.4); 2.1704 (6.0); 2.1687 (6.5); 2.1658 (6.5); 2.1642δ = 8.6779 (1.2); 8.6658 (1.2); 7.6445 (0.8); 7.4465 (0.7); 7.4361 (0.7); 7.4256 (0.6); 7.3451 (1.8); 7.2614 (40.3); 4.1353 (0.6); 4.1187 (0.7); 3.6324 (0.6); 2.5997 (0.7); 2.5185 (1.4); 2.1704 (6.0); 2.1687 (6.5); 2.1658 (6.5); 2.1642

(5.9) ; 1.8348 (16.0); 1.2512 (1.3); -0.0002 (14.8) 1.74-213: 1 H-NMR(400.0 MHz, CDCI3): (5.9); 1.8348 (16.0); 1.2512 (1.3); -0.0002 (14.8) 1.74-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5366 (0.8); 8.5250 (0.8); 7.5381 (0.5); 7.5343 (0.7); 7.5126 (0.6); 7.5092 (0.6); 7.5013 (1.5); 7.4996 (1.5); 7.3444 (0.5); 7.3344 (0.6); 7.3330 (0.6); 7.3232 (0.9); 7.2606 (14.6); 4.1096 (3.4); 4.0953 (3.4); 2.2516 (5.9); 1.8857δ = 8.5366 (0.8); 8.5250 (0.8); 7.5381 (0.5); 7.5343 (0.7); 7.5126 (0.6); 7.5092 (0.6); 7.5013 (1.5); 7.4996 (1.5); 7.3444 (0.5); 7.3344 (0.6); 7.3330 (0.6); 7.3232 (0.9); 7.2606 (14.6); 4.1096 (3.4); 4.0953 (3.4); 2.2516 (5.9); 1.8857

(16.0); -0.0002 (5.4) (16.0); -0.0002 (5.4)

1.74-214: 1 H-NMR(400.0 MHz, CDCI3):  1.74-214: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5241 (0.8); 8.5125 (0.8); 7.4922 (0.5); 7.4886 (0.8); 7.3614 (1.4); 7.3599 (1.4); 7.3057 (0.6); 7.3042 (0.6); 7.2945 (0.8); 7.2605 (28.3); 4.3568 (1.3); 3.1502 (2.3); 2.2077 (3.4); 2.2058 (5.5); 2.2039 (3.3); 2.1491 (2.4); 1.8686δ = 8.5241 (0.8); 8.5125 (0.8); 7.4922 (0.5); 7.4886 (0.8); 7.3614 (1.4); 7.3599 (1.4); 7.3057 (0.6); 7.3042 (0.6); 7.2945 (0.8); 7.2605 (28.3); 4.3568 (1.3); 3.1502 (2.3); 2.2077 (3.4); 2.2058 (5.5); 2.2039 (3.3); 2.1491 (2.4); 1.8686

(16.0); 1.5565 (0.6); -0.0002 (10.6) (16.0); 1.5565 (0.6); -0.0002 (10.6)

1.74-216: 1 H-NMR(400.0 MHz, CDCI3):  1.74-216: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5249 (0.8); 8.5211 (0.5); 8.5173 (0.5); 8.5134 (0.8); 7.5139 (0.6); 7.5103 (0.7); 7.5035 (1.6); 7.4880 (0.6); 7.4846 (0.6); 7.3256 (0.6); 7.3157 (0.7); 7.3142 (0.6); 7.3045 (1.0); 7.2948 (0.5); 7.2932 (0.6); 7.2599 (46.3); 2.2707 (5.7); 1.8623 (16.0); 1.7030 (0.6); 1.6514 (12.0); 1.6506 (11.9); 1.5440 (1.9); 1.4484 (1.0); 1.2559 (0.8); -0.0002δ = 8.5249 (0.8); 8.5211 (0.5); 8.5173 (0.5); 8.5134 (0.8); 7.5139 (0.6); 7.5103 (0.7); 7.5035 (1.6); 7.4880 (0.6); 7.4846 (0.6); 7.3256 (0.6); 7.3157 (0.7); 7.3142 (0.6); 7.3045 (1.0); 7.2948 (0.5); 7.2932 (0.6); 7.2599 (46.3); 2.2707 (5.7); 1.8623 (16.0); 1.7030 (0.6); 1.6514 (12.0); 1.6506 (11.9); 1.5440 (1.9); 1.4484 (1.0); 1.2559 (0.8); -0.0002

(17.2); -0.0085 (0.6) (17.2); -0.0085 (0.6)

I.74-227: 1 H-NMR(400.0 MHz, CDCI3):  I.74-227: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5305 (0.8); 8.5189 (0.8); 7.5232 (0.6); 7.5195 (0.8); 7.5051 (1.5); 7.5034 (1.5); 7.4978 (0.6); 7.4943 (0.6); 7.3305 (0.5); 7.3206 (0.6); 7.3191 (0.6); 7.3094 (0.9); 7.2996 (0.5); 7.2982 (0.5); 7.2607 (18.5); 3.4731 (0.7); 3.4561 (1.6); 3.4409 (1.7); 3.4240 (0.7); 2.5869 (1.6); 2.5700 (3.3); 2.5529 (1.5); 2.2454 (6.0); 1.8778 (16.0); 1.6059 (1.1); -δ = 8.5305 (0.8); 8.5189 (0.8); 7.5232 (0.6); 7.5195 (0.8); 7.5051 (1.5); 7.5034 (1.5); 7.4978 (0.6); 7.4943 (0.6); 7.3305 (0.5); 7.3206 (0.6); 7.3191 (0.6); 7.3094 (0.9); 7.2996 (0.5); 7.2982 (0.5); 7.2607 (18.5); 3.4731 (0.7); 3.4561 (1.6); 3.4409 (1.7); 3.4240 (0.7); 2.5869 (1.6); 2.5700 (3.3); 2.5529 (1.5); 2.2454 (6.0); 1.8778 (16.0); 1.6059 (1.1); -

0.0002 (7.0) 0.0002 (7.0)

I.74-228: 1 H-NMR(400.0 MHz, CDCI3):  I.74-228: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5206 (0.5); 8.5169 (0.9); 8.5131 (0.5); 8.5090 (0.6); 8.5053 (0.9); 8.5015 (0.5); 7.4843 (0.6); 7.4807 (1.0); 7.4769 (0.5); 7.4595 (0.6); 7.4560 (0.6); 7.3862 (1.4); 7.3027 (0.5); 7.2929 (0.7); 7.2913 (0.6); 7.2816 (0.9); 7.2719 (0.6); 7.2705 (0.6); 7.2605 (34.6); 2.5989 (0.6); 2.2148 (4.0); 2.2130 (6.6); 2.2111 (3.9); 1.8802 (0.6); 1.8467 (16.0);δ = 8.5206 (0.5); 8.5169 (0.9); 8.5131 (0.5); 8.5090 (0.6); 8.5053 (0.9); 8.5015 (0.5); 7.4843 (0.6); 7.4807 (1.0); 7.4769 (0.5); 7.4595 (0.6); 7.4560 (0.6); 7.3862 (1.4); 7.3027 (0.5); 7.2929 (0.7); 7.2913 (0.6); 7.2816 (0.9); 7.2719 (0.6); 7.2705 (0.6); 7.2605 (34.6); 2.5989 (0.6); 2.2148 (4.0); 2.2130 (6.6); 2.2111 (3.9); 1.8802 (0.6); 1.8467 (16.0);

1.5556 (1.9); -0.0002 (12.8) 1.5556 (1.9); -0.0002 (12.8)

I.74-3: 1 H-NMR(400.0 MHz, CDCI3):  I.74-3: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5326 (0.8); 8.5248 (0.5); 8.5210 (0.8); 7.5341 (0.6); 7.5305 (0.6); 7.5295 (0.6); 7.5083 (0.5); 7.5049 (0.5); 7.4791 (1.5); 7.4774 (1.5); 7.3396 (0.5); 7.3296 (0.6); 7.3281 (0.6); 7.3184 (0.9); 7.3087 (0.6); 7.3072 (0.5); 7.2605 (24.9); 2.2522 (5.9); 1.8513 (16.0); 1.5730 (1.2); 1.5203 (0.7); 1.5052 (1.4); 1.4994 (1.6); 1.4966 (0.9); 1.4850 (0.8);δ = 8.5326 (0.8); 8.5248 (0.5); 8.5210 (0.8); 7.5341 (0.6); 7.5305 (0.6); 7.5295 (0.6); 7.5083 (0.5); 7.5049 (0.5); 7.4791 (1.5); 7.4774 (1.5); 7.3396 (0.5); 7.3296 (0.6); 7.3281 (0.6); 7.3184 (0.9); 7.3087 (0.6); 7.3072 (0.5); 7.2605 (24.9); 2.2522 (5.9); 1.8513 (16.0); 1.5730 (1.2); 1.5203 (0.7); 1.5052 (1.4); 1.4994 (1.6); 1.4966 (0.9); 1.4850 (0.8);

1.1734 (0.8); 1.1590 (1.5); 1.1531 (1.4); 1.1380 (0.7); -0.0002 (9.2) 1.1734 (0.8); 1.1590 (1.5); 1.1531 (1.4); 1.1380 (0.7); -0.0002 (9.2)

I.74-303: 1 H-NMR(400.0 MHz, CDCI3):  I.74-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5108 (0.7); 8.4992 (0.8); 7.4620 (0.5); 7.4585 (0.8); 7.4214 (1.5); 7.4195 (1.5); 7.2734 (0.7); 7.2719 (0.6); 7.2601 (30.6); 7.2528 (0.7); 3.1516 (6.8); 3.0212 (3.6); 2.1979 (3.3); 2.1961 (5.4); 2.1942 (3.3); 1.8480 (16.0); 1.2549δ = 8.5108 (0.7); 8.4992 (0.8); 7.4620 (0.5); 7.4585 (0.8); 7.4214 (1.5); 7.4195 (1.5); 7.2734 (0.7); 7.2719 (0.6); 7.2601 (30.6); 7.2528 (0.7); 3.1516 (6.8); 3.0212 (3.6); 2.1979 (3.3); 2.1961 (5.4); 2.1942 (3.3); 1.8480 (16.0); 1.2549

(1.2); -0.0002 (11.1) (1.2); -0.0002 (11.1)

I.74-353: 1 H-NMR(400.0 MHz, d6-DMSO):  I.74-353: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 10.9797 (1.4); 8.5139 (0.8); 8.5095 (1.2); 8.5059 (0.9); 8.5024 (0.9); 8.4980 (1.3); 8.4945 (0.9); 7.8072 (0.7); 7.8039 (0.8); 7.7862 (0.9); 7.7828 (1.0); 7.7804 (1.0); 7.7718 (2.3); 7.7594 (0.9); 7.7561 (0.9); 7.4767 (1.0); 7.4669δ = 10.9797 (1.4); 8.5139 (0.8); 8.5095 (1.2); 8.5059 (0.9); 8.5024 (0.9); 8.4980 (1.3); 8.4945 (0.9); 7.8072 (0.7); 7.8039 (0.8); 7.7862 (0.9); 7.7828 (1.0); 7.7804 (1.0); 7.7718 (2.3); 7.7594 (0.9); 7.7561 (0.9); 7.4767 (1.0); 7.4669

(1.1) ; 7.4654 (1.0); 7.4556 (1.6); 7.4444 (0.9); 7.4346 (0.7); 4.6238 (0.8); 4.6093 (1.5); 4.5947 (0.8); 3.7933 (1.0); 3.7817 (1.6); 3.7689 (1.1); 3.5401 (0.7); 3.5269 (1.4); 3.5138 (1.2); 3.5006 (0.5); 3.3265 (31.1); 2.5386 (1.0); 2.5340(1.1); 7.4654 (1.0); 7.4556 (1.6); 7.4444 (0.9); 7.4346 (0.7); 4.6238 (0.8); 4.6093 (1.5); 4.5947 (0.8); 3.7933 (1.0); 3.7817 (1.6); 3.7689 (1.1); 3.5401 (0.7); 3.5269 (1.4); 3.5138 (1.2); 3.5006 (0.5); 3.3265 (31.1); 2.5386 (1.0); 2.5340

(1.4); 2.5252 (17.4); 2.5207 (36.8); 2.5161 (50.9); 2.5115 (34.9); 2.5069 (15.6); 2.1762 (8.0); 1.7286 (16.0) (1.4); 2.5252 (17.4); 2.5207 (36.8); 2.5161 (50.9); 2.5115 (34.9); 2.5069 (15.6); 2.1762 (8.0); 1.7286 (16.0)

I.74-59: 1 H-NMR(400.0 MHz, CDCI3):  I.74-59: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5621 (0.8); 8.5582 (0.5); 8.5544 (0.5); 8.5505 (0.8); 7.7207 (0.8); 7.7156 (1.6); 7.7105 (0.8); 7.5815 (0.6); 7.5779 (0.7); 7.5732 (0.5); 7.5551 (1.9); 7.5526 (2.0); 7.3552 (0.7); 7.3537 (0.7); 7.3512 (0.6); 7.3483 (0.7); 7.3457δ = 8.5621 (0.8); 8.5582 (0.5); 8.5544 (0.5); 8.5505 (0.8); 7.7207 (0.8); 7.7156 (1.6); 7.7105 (0.8); 7.5815 (0.6); 7.5779 (0.7); 7.5732 (0.5); 7.5551 (1.9); 7.5526 (2.0); 7.3552 (0.7); 7.3537 (0.7); 7.3512 (0.6); 7.3483 (0.7); 7.3457

(1.2) ; 7.3343 (1.0); 7.3245 (0.6); 7.3231 (0.6); 7.2592 (26.2); 7.2239 (0.8); 7.2038 (1.6); 7.1836 (0.8); 7.0610 (0.6); 7.0586 (0.7); 7.0560 (0.6); 7.0536 (0.6); 7.0386 (0.5); 7.0360 (0.5); 5.2978 (1.1); 2.2775 (6.3); 1.9470 (16.0); 1.5465 (2.1); -0.0002 (9.8) (1.2); 7.3343 (1.0); 7.3245 (0.6); 7.3231 (0.6); 7.2592 (26.2); 7.2239 (0.8); 7.2038 (1.6); 7.1836 (0.8); 7.0610 (0.6); 7.0586 (0.7); 7.0560 (0.6); 7.0536 (0.6); 7.0386 (0.5); 7.0360 (0.5); 5.2978 (1.1); 2.2775 (6.3); 1.9470 (16.0); 1.5465 (2.1); -0.0002 (9.8)

1.74- 63: 1 H-NMR(400.0 MHz, CDCI3):  1.74-63: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5769 (0.5); 8.5730 (0.8); 8.5692 (0.5); 8.5654 (0.6); 8.5615 (0.8); 8.5576 (0.5); 7.9731 (0.7); 7.9689 (1.1); 7.9648 (0.7); 7.7844 (0.6); 7.7689 (0.5); 7.7648 (0.6); 7.7635 (0.6); 7.7595 (0.5); 7.5996 (0.6); 7.5961 (0.7); 7.5946 (0.6); 7.5911 (0.5); 7.5735 (0.6); 7.5701 (0.6); 7.5622 (1.6); 7.5607 (1.6); 7.3923 (1.2); 7.3718 (1.5); 7.3659 (0.9); 7.3619 (2.2); 7.3586 (1.0); 7.3504 (1.0); 7.3428 (0.6); 7.3405 (0.7); 7.3393 (0.8); 7.2600 (21.0); 5.2981 (2.6); 2.2837 (6.4); 1.9517 (16.0); 1.5559 (1.7); -0.0002 (7.8) δ = 8.5769 (0.5); 8.5730 (0.8); 8.5692 (0.5); 8.5654 (0.6); 8.5615 (0.8); 8.5576 (0.5); 7.9731 (0.7); 7.9689 (1.1); 7.9648 (0.7); 7.7844 (0.6); 7.7689 (0.5); 7.7648 (0.6); 7.7635 (0.6); 7.7595 (0.5); 7.5996 (0.6); 7.5961 (0.7); 7.5946 (0.6); 7.5911 (0.5); 7.5735 (0.6); 7.5701 (0.6); 7.5622 (1.6); 7.5607 (1.6); 7.3923 (1.2); 7.3718 (1.5); 7.3659 (0.9); 7.3619 (2.2); 7.3586 (1.0); 7.3504 (1.0); 7.3428 (0.6); 7.3405 (0.7); 7.3393 (0.8); 7.2600 (21.0); 5.2981 (2.6); 2.2837 (6.4); 1.9517 (16.0); 1.5559 (1.7); -0.0002 (7.8)

1.75- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.75-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.6120 (1.0); 8.6082 (1.0); 8.6003 (1.0); 8.5965 (1.0); 7.8353 (1.0); 7.8315 (1.0); 7.8150 (1.1); 7.8112 (1.1); 7.4766 (1.7); 7.4746 (1.7); 7.2833 (1.1); 7.2716 (1.2); 7.2609 (30.6); 7.2513 (1.2); 2.6571 (0.6); 2.6485 (0.6); 2.1228 (6.4); 2.1210 (6.1); 1.8472 (16.0); 1.5660 (6.2); 0.7036 (0.9); 0.7000 (1.3); 0.6859 (1.2); 0.6821 (1.0); 0.6794 (0.6);δ = 8.6120 (1.0); 8.6082 (1.0); 8.6003 (1.0); 8.5965 (1.0); 7.8353 (1.0); 7.8315 (1.0); 7.8150 (1.1); 7.8112 (1.1); 7.4766 (1.7); 7.4746 (1.7); 7.2833 (1.1); 7.2716 (1.2); 7.2609 (30.6); 7.2513 (1.2); 2.6571 (0.6); 2.6485 (0.6); 2.1228 (6.4); 2.1210 (6.1); 1.8472 (16.0); 1.5660 (6.2); 0.7036 (0.9); 0.7000 (1.3); 0.6859 (1.2); 0.6821 (1.0); 0.6794 (0.6);

0.3974 (0.9); 0.3945 (1.0); 0.3909 (1.0); 0.3847 (1.0); 0.3812 (0.9); -0.0002 (10.5) 0.3974 (0.9); 0.3945 (1.0); 0.3909 (1.0); 0.3847 (1.0); 0.3812 (0.9); -0.0002 (10.5)

1.75-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.75-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6021 (1.0); 8.5983 (1.0); 8.5904 (1.0); 8.5867 (1.0); 7.8006 (1.0); 7.7968 (1.0); 7.7803 (1.1); 7.7765 (1.0); 7.3627 (1.7); 7.3607 (1.7); 7.2606 (51.3); 7.2544 (1.8); 7.2427 (1.3); 7.2340 (1.1); 7.2223 (1.0); 3.5270 (1.0); 2.6913 (1.0); 2.0979 (6.1); 2.0961 (6.0); 1.8647 (0.9); 1.8337 (16.0); 1.7310 (0.6); 1.7141 (1.8); 1.7068 (1.2); 1.6970 (0.6); 1.5598 (8.0); 0.0080 (0.6); -0.0002 (17.4); -0.0085 (0.6) 1.75-102: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6021 (1.0); 8.5983 (1.0); 8.5904 (1.0); 8.5867 (1.0); 7.8006 (1.0); 7.7968 (1.0); 7.7803 (1.1); 7.7765 (1.0); 7.3627 (1.7); 7.3607 (1.7); 7.2606 (51.3); 7.2544 (1.8); 7.2427 (1.3); 7.2340 (1.1); 7.2223 (1.0); 3.5270 (1.0); 2.6913 (1.0); 2.0979 (6.1); 2.0961 (6.0); 1.8647 (0.9); 1.8337 (16.0); 1.7310 (0.6); 1.7141 (1.8); 1.7068 (1.2); 1.6970 (0.6); 1.5598 (8.0); 0.0080 (0.6); -0.0002 (17.4); -0.0085 (0.6) 1.75-102: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6012 (1.8); 8.5976 (1.9); 8.5896 (1.9); 8.5859 (1.8); 7.8004 (2.0); 7.7966 (2.0); 7.7801 (2.2); 7.7763 (2.1); 7.5188 (0.6); 7.3376 (4.1); 7.3357 (4.1); 7.3100 (0.7); 7.2600 (98.8); 7.2512 (3.5); 7.2394 (2.1); 7.2308 (2.0); 7.2191 (1.9); 6.9960 (0.5); 4.2842 (0.5); 4.2762 (0.7); 4.2678 (0.6); 4.2598 (0.6); 2.7349 (2.1); 2.7169 (3.2); 2.7013 (1.7); 2.0997 (13.6); 2.0982 (13.8); 1.8791 (0.6); 1.8565 (0.9); 1.8450 (0.7); 1.8381 (0.8); 1.8189 (16.0); 1.8151 (15.2); 1.7806 (0.7); 1.7645 (0.7); 1.6567 (0.6); 1.6441 (0.8); 1.6290 (0.9); 1.6138 (0.8); 1.5985 (0.5); 1.5491 (3.3); 1.4451 (0.5); 1.4390 (0.6); 1.4294 (0.7); 1.4256 (0.8); 1.4164 (0.7); 1.4122 (0.6); 1.4000 (0.6); 1.3331 (1.0); 1.2843 (1.3);δ = 8.6012 (1.8); 8.5976 (1.9); 8.5896 (1.9); 8.5859 (1.8); 7.8004 (2.0); 7.7966 (2.0); 7.7801 (2.2); 7.7763 (2.1); 7.5188 (0.6); 7.3376 (4.1); 7.3357 (4.1); 7.3100 (0.7); 7.2600 (98.8); 7.2512 (3.5); 7.2394 (2.1); 7.2308 (2.0); 7.2191 (1.9); 6.9960 (0.5); 4.2842 (0.5); 4.2762 (0.7); 4.2678 (0.6); 4.2598 (0.6); 2.7349 (2.1); 2.7169 (3.2); 2.7013 (1.7); 2.0997 (13.6); 2.0982 (13.8); 1.8791 (0.6); 1.8565 (0.9); 1.8450 (0.7); 1.8381 (0.8); 1.8189 (16.0); 1.8151 (15.2); 1.7806 (0.7); 1.7645 (0.7); 1.6567 (0.6); 1.6441 (0.8); 1.6290 (0.9); 1.6138 (0.8); 1.5985 (0.5); 1.5491 (3.3); 1.4451 (0.5); 1.4390 (0.6); 1.4294 (0.7); 1.4256 (0.8); 1.4164 (0.7); 1.4122 (0.6); 1.4000 (0.6); 1.3331 (1.0); 1.2843 (1.3);

1.2560 (0.7); 1.2126 (8.2); 1.1969 (8.2); 0.0080 (1.7); -0.0002 (57.5); -0.0084 (2.4) 1.2560 (0.7); 1.2126 (8.2); 1.1969 (8.2); 0.0080 (1.7); -0.0002 (57.5); -0.0084 (2.4)

1.75-167: 1 H-NMR(400.0 MHz, CDCI3):  1.75-167: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6048 (0.9); 8.6010 (0.9); 8.5931 (0.9); 8.5893 (0.9); 7.8033 (1.0); 7.7995 (1.0); 7.7830 (1.0); 7.7792 (1.0); 7.3184 (1.6); 7.3164 (1.6); 7.2620 (18.8); 7.2560 (1.3); 7.2443 (1.0); 7.2356 (1.0); 7.2239 (0.9); 2.0988 (5.8); 2.0969δ = 8.6048 (0.9); 8.6010 (0.9); 8.5931 (0.9); 8,5893 (0.9); 7.8033 (1.0); 7.7995 (1.0); 7.7830 (1.0); 7.7792 (1.0); 7.3184 (1.6); 7.3164 (1.6); 7.2620 (18.8); 7.2560 (1.3); 7.2443 (1.0); 7.2356 (1.0); 7.2239 (0.9); 2.0988 (5.8); 2.0969

(5.8); 1.8405 (16.0); 1.5887 (1.2); -0.0002 (6.5) (5.8); 1.8405 (16.0); 1.5887 (1.2); -0.0002 (6.5)

1.75-171 : 1 H-NMR(400.0 MHz, CDCI3):  1.75-171: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6088 (0.8); 8.6051 (0.9); 8.5971 (0.8); 8.5934 (0.9); 7.8070 (1.2); 7.8033 (1.2); 7.7867 (1.3); 7.7829 (1.2); 7.4500 (0.9); 7.2603 (91.8); 7.2484 (1.9); 7.2397 (1.5); 7.2280 (1.4); 6.9963 (0.5); 4.0648 (1.8); 3.7532 (3.2); 3.7393 (0.6); 2.6032 (2.9); 2.1086 (4.2); 1.8641 (6.9); 1.8405 (0.7); 1.5503 (16.0); 0.0080 (1.0); -0.0002 (31.1); -0.0085 (1.1) 1.75-213: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.6088 (0.8); 8.6051 (0.9); 8,55971 (0.8); 8.5934 (0.9); 7.8070 (1.2); 7.8033 (1.2); 7.7867 (1.3); 7.7829 (1.2); 7.4500 (0.9); 7.2603 (91.8); 7.2484 (1.9); 7.2397 (1.5); 7.2280 (1.4); 6.9963 (0.5); 4.0648 (1.8); 3.7532 (3.2); 3.7393 (0.6); 2.6032 (2.9); 2.1086 (4.2); 1.8641 (6.9); 1.8405 (0.7); 1.5503 (16.0); 0.0080 (1.0); -0.0002 (31.1); -0.0085 (1.1) 1.75-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6212 (0.9); 8.6174 (1.0); 8.6095 (1.0); 8.6058 (1.0); 7.8608 (1.0); 7.8570 (1.0); 7.8404 (1.1); 7.8366 (1.0); 7.5063 (1.7); 7.5043 (1.8); 7.3056 (1.1); 7.2939 (1.0); 7.2852 (1.0); 7.2735 (1.0); 7.2608 (19.6); 4.1043 (3.4); 4.0900δ = 8.6212 (0.9); 8.6174 (1.0); 8.6095 (1.0); 8.6058 (1.0); 7.8608 (1.0); 7.8570 (1.0); 7.8404 (1.1); 7.8366 (1.0); 7.5063 (1.7); 7.5043 (1.8); 7.3056 (1.1); 7.2939 (1.0); 7.2852 (1.0); 7.2735 (1.0); 7.2608 (19.6); 4.1043 (3.4); 4.0900

(3.4); 2.1500 (6.2); 2.1481 (6.6); 1.8795 (16.0); 1.6196 (0.9); -0.0002 (7.5) (3.4); 2.1500 (6.2); 2.1481 (6.6); 1.8795 (16.0); 1.6196 (0.9); -0.0002 (7.5)

I.75-284: 1 H-NMR(400.0 MHz, CDCI3):  I.75-284: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6240 (0.8); 8.6203 (0.8); 8.6122 (1.6); 8.6084 (1.6); 8.6003 (0.9); 8.5965 (0.9); 7.8503 (0.8); 7.8465 (0.9); 7.8299 (0.9); 7.8262 (0.9); 7.8096 (0.9); 7.8058 (0.9); 7.7893 (1.0); 7.7855 (0.9); 7.5080 (1.6); 7.5062 (1.5); 7.3187 (1.6); 7.3168 (1.6); 7.2961 (0.9); 7.2845 (0.9); 7.2757 (1.0); 7.2602 (49.2); 7.2543 (2.3); 7.2454 (1.0); 7.2337 (0.9); 4.1307 (1.1); 4.1128 (1.1); 2.1903 (5.7); 2.1886 (5.5); 2.0935 (5.8); 2.0918 (5.6); 2.0434 (5.0); 1.8789 (16.0); 1.8437δ = 8.6240 (0.8); 8.6203 (0.8); 8.6122 (1.6); 8.6084 (1.6); 8.6003 (0.9); 8.5965 (0.9); 7.8503 (0.8); 7.8465 (0.9); 7.8299 (0.9); 7.8262 (0.9); 7.8096 (0.9); 7.8058 (0.9); 7.7893 (1.0); 7.7855 (0.9); 7.5080 (1.6); 7.5062 (1.5); 7.3187 (1.6); 7.3168 (1.6); 7.2961 (0.9); 7.2845 (0.9); 7.2757 (1.0); 7.2602 (49.2); 7.2543 (2.3); 7.2454 (1.0); 7.2337 (0.9); 4.1307 (1.1); 4.1128 (1.1); 2.1903 (5.7); 2.1886 (5.5); 2.0935 (5.8); 2.0918 (5.6); 2.0434 (5.0); 1.8789 (16.0); 1.8437

(13.1); 1.2764 (1.4); 1.2585 (2.8); 1.2406 (1.3); 0.0079 (0.8); -0.0002 (27.4); -0.0085 (1.1) (13.1); 1.2764 (1.4); 1.2585 (2.8); 1.2406 (1.3); 0.0079 (0.8); -0.0002 (27.4); -0.0085 (1.1)

I.75-303: 1 H-NMR(400.0 MHz, CDCI3):  I.75-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5900 (0.9); 8.5863 (1.0); 8.5784 (1.0); 8.5746 (1.0); 7.7840 (1.1); 7.7801 (1.0); 7.7637 (1.2); 7.7598 (1.1); 7.4131 (1.7); 7.4112 (1.7); 7.2605 (65.6); 7.2352 (1.1); 7.2236 (1.0); 7.2150 (1.0); 7.2033 (1.0); 3.7045 (1.1); 3.1489 (6.8); 3.0590 (3.5); 2.1329 (0.6); 2.1310 (0.6); 2.1150 (6.0); 2.1131 (6.6); 1.8817 (1.8); 1.8645 (1.5); 1.8466 (16.0);δ = 8.5900 (0.9); 8.5863 (1.0); 8.5784 (1.0); 8.5746 (1.0); 7.7840 (1.1); 7.7801 (1.0); 7.7637 (1.2); 7.7598 (1.1); 7.4131 (1.7); 7.4112 (1.7); 7.2605 (65.6); 7.2352 (1.1); 7.2236 (1.0); 7.2150 (1.0); 7.2033 (1.0); 3.7045 (1.1); 3.1489 (6.8); 3.0590 (3.5); 2.1329 (0.6); 2.1310 (0.6); 2.1150 (6.0); 2.1131 (6.6); 1.8817 (1.8); 1.8645 (1.5); 1.8466 (16.0);

1.5556 (13.5); 0.0080 (0.6); -0.0002 (22.4); -0.0084 (0.7) 1.5556 (13.5); 0.0080 (0.6); -0.0002 (22.4); -0.0084 (0.7)

1.77-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.77-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5287 (0.5); 8.5196 (0.5); 7.4542 (1.6); 7.4522 (1.6); 7.2623 (11.2); 7.1974 (0.6); 7.1856 (0.6); 7.1782 (0.5); 2.6220 (0.6); 2.6138 (0.6); 2.4086 (5.7); 2.1572 (6.0); 2.1554 (6.0); 1.8342 (16.0); 0.6966 (0.9); 0.6932 (1.3); 0.6905 (0.6); 0.6790 (1.1); 0.6753 (1.0); 0.6725 (0.5); 0.3633 (0.8); 0.3603 (0.9); 0.3569 (0.9); 0.3543 (0.7); 0.3506 (0.9);δ = 8.5287 (0.5); 8.5196 (0.5); 7.4542 (1.6); 7.4522 (1.6); 7.2623 (11.2); 7.1974 (0.6); 7.1856 (0.6); 7.1782 (0.5); 2.6220 (0.6); 2.6138 (0.6); 2.4086 (5.7); 2.1572 (6.0); 2.1554 (6.0); 1.8342 (16.0); 0.6966 (0.9); 0.6932 (1.3); 0.6905 (0.6); 0.6790 (1.1); 0.6753 (1.0); 0.6725 (0.5); 0.3633 (0.8); 0.3603 (0.9); 0.3569 (0.9); 0.3543 (0.7); 0.3506 (0.9);

0.3472 (0.8); -0.0002 (4.1) 0.3472 (0.8); -0.0002 (4.1)

1.77-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.77-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5098 (0.5); 7.3492 (1.6); 7.3472 (1.6); 7.2644 (7.8); 7.1548 (0.6); 7.1429 (0.6); 7.1356 (0.6); 7.1237 (0.5); 3.5294 (0.9); 2.6738 (0.9); 2.4043 (5.5); 2.1737 (5.9); 2.1719 (5.9); 1.8090 (16.0); 1.7168 (1.1); 1.7093 (1.4); 1.7014δ = 8.5098 (0.5); 7.3492 (1.6); 7.3472 (1.6); 7.2644 (7.8); 7.1548 (0.6); 7.1429 (0.6); 7.1356 (0.6); 7.1237 (0.5); 3.5294 (0.9); 2.6738 (0.9); 2.4043 (5.5); 2.1737 (5.9); 2.1719 (5.9); 1.8090 (16.0); 1.7168 (1.1); 1.7093 (1.4); 1.7014

(1.2); -0.0002 (3.0) (1.2); -0.0002 (3.0)

1.77-152: 1 H-NMR(400.0 MHz, CDCI3):  1.77-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5174 (0.5); 8.5083 (0.5); 8.5055 (0.5); 7.3228 (1.6); 7.3208 (1.7); 7.2633 (8.9); 7.1709 (0.6); 7.1590 (0.6); 7.1517 (0.5); 7.1398 (0.5); 5.2978 (0.9); 2.3898 (5.5); 2.1617 (6.0); 2.1597 (6.1); 1.8170 (16.0); 1.2580 (0.6); -0.0002 (3-4) δ = 8.5174 (0.5); 8.5083 (0.5); 8.5055 (0.5); 7.3228 (1.6); 7.3208 (1.7); 7.2633 (8.9); 7.1709 (0.6); 7.1590 (0.6); 7.1517 (0.5); 7.1398 (0.5); 5.2978 (0.9); 2.3898 (5.5); 2.1617 (6.0); 2.1597 (6.1); 1.8170 (16.0); 1.2580 (0.6); -0.0002 (3-4)

1.77- 329: 1 H-NMR(400.0 MHz, CDCI3):  1.77-329: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5158 (0.7); 8.5039 (0.7); 7.5910 (0.6); 7.5725 (0.6); 7.5187 (0.6); 7.5101 (2.0); 7.5082 (2.0); 7.2599 (88.5); 7.1848 (0.5); 7.1656 (0.5); 5.2983 (2.9); 4.1304 (0.5); 4.1126 (0.6); 2.4270 (5.9); 2.1638 (7.9); 2.1620 (7.8); 2.0434 (2.6); 1.9081 (16.0); 1.5665 (3.9); 1.2763 (0.8); 1.2585 (1.9); 1.2407 (0.7); 1.0020 (1.4); 0.9946 (1.6); 0.9907 (1.3); 0.9834 (1.5); 0.8198 (0.7); 0.8119 (0.8); 0.8000 (0.8); 0.7927 (0.7); 0.0080 (1.5); -0.0002 (48.1); -0.0085 (1.7)δ = 8.5158 (0.7); 8.5039 (0.7); 7.5910 (0.6); 7.5725 (0.6); 7.5187 (0.6); 7.5101 (2.0); 7.5082 (2.0); 7.2599 (88.5); 7.1848 (0.5); 7.1656 (0.5); 5.2983 (2.9); 4.1304 (0.5); 4.1126 (0.6); 2.4270 (5.9); 2.1638 (7.9); 2.1620 (7.8); 2.0434 (2.6); 1.9081 (16.0); 1.5665 (3.9); 1.2763 (0.8); 1.2585 (1.9); 1.2407 (0.7); 1.0020 (1.4); 0.9946 (1.6); 0.9907 (1.3); 0.9834 (1.5); 0.8198 (0.7); 0.8119 (0.8); 0.8000 (0.8); 0.7927 (0.7); 0.0080 (1.5); -0.0002 (48.1); -0.0085 (1.7)

1.78- 2: 1 H-NMR(400.0 MHz, CDCI3): 1.78-2: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4327 (1.8); 7.4310 (1.7); 7.3476 (1.7); 7.3342 (1.8); 7.2598 (28.9); 7.0389 (1.8); 7.0255 (1.7); 2.1355 (6.3); 2.1340 (6.3); 1.8121 (16.0); 1.7921 (0.7); 1.5409 (5.0); 1.3011 (6.8); 0.6158 (1.5); 0.6043 (1.2); 0.5742 (1.4); 0.5625δ = 7.4327 (1.8); 7.4310 (1.7); 7.3476 (1.7); 7.3342 (1.8); 7.2598 (28.9); 7.0389 (1.8); 7.0255 (1.7); 2.1355 (6.3); 2.1340 (6.3); 1.8121 (16.0); 1.7921 (0.7); 1.5409 (5.0); 1.3011 (6.8); 0.6158 (1.5); 0.6043 (1.2); 0.5742 (1.4); 0.5625

(1.6); 0.0079 (0.7); -0.0002 (16.7); -0.0083 (0.7) (1.6); 0.0079 (0.7); -0.0002 (16.7); -0.0083 (0.7)

1.78-19: 1 H-NMR(400.0 MHz, CDCI3):  1.78-19: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4536 (3.7); 7.4516 (3.7); 7.3627 (4.5); 7.3493 (4.9); 7.3298 (0.7); 7.2601 (20.6); 7.0490 (4.8); 7.0355 (4.5); 3.0117 (0.7); 3.0079 (0.5); 3.0035 (0.5); 2.9997 (1.1); 2.9916 (1.1); 2.9877 (0.5); 2.9834 (0.5); 2.9795 (0.7); 2.2598 (0.7); 2.2578 (0.7); 2.1434 (13.6); 2.1415 (13.5); 2.0429 (0.6); 1.8375 (16.0); 1.8349 (15.9); 1.8178 (1.9); 1.6292 (0.5); 1.6207 (0.7); 1.6123 (0.7); 1.6039 (0.8); 1.5954 (0.6); 1.2582 (0.6); 1.2303 (0.6); 1.2145 (1.3); 1.2102 (0.8); 1.1986 (0.8); 1.1943 (1.3); 1.1786 (0.6); 0.9681 (0.6); 0.9663 (0.6); 0.9559 (0.6); 0.9542 (0.6); 0.9439 (0.6); 0.9420δ = 7.4536 (3.7); 7.4516 (3.7); 7.3627 (4.5); 7.3493 (4.9); 7.3298 (0.7); 7.2601 (20.6); 7.0490 (4.8); 7.0355 (4.5); 3.0117 (0.7); 3.0079 (0.5); 3.0035 (0.5); 2.9997 (1.1); 2.9916 (1.1); 2,987 (0.5); 2.9834 (0.5); 2.9795 (0.7); 2.2598 (0.7); 2.2578 (0.7); 2.1434 (13.6); 2.1415 (13.5); 2.0429 (0.6); 1.8375 (16.0); 1.8349 (15.9); 1.8178 (1.9); 1.6292 (0.5); 1.6207 (0.7); 1.6123 (0.7); 1.6039 (0.8); 1.5954 (0.6); 1.2582 (0.6); 1.2303 (0.6); 1.2145 (1.3); 1.2102 (0.8); 1.1986 (0.8); 1.1943 (1.3); 1.1786 (0.6); 0.9681 (0.6); 0.9663 (0.6); 0.9559 (0.6); 0.9542 (0.6); 0.9439 (0.6); 0.9420

(0.6); -0.0002 (11.7) (0.6); -0.0002 (11.7)

I.78-20: 1 H-NMR(400.0 MHz, CDCI3):  I.78-20: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4620 (1.8); 7.4600 (1.7); 7.3394 (2.0); 7.3260 (2.2); 7.2597 (30.9); 7.0245 (2.2); 7.0111 (2.0); 2.4301 (0.6); 2.4205 (0.7); 2.4109 (0.6); 2.1326 (6.6); 2.1307 (6.2); 1.8579 (16.0); 1.8387 (0.5); 1.5423 (4.4); 1.0516 (7.5); 0.9025 (7.6); 0.6808 (0.5); 0.6671 (0.6); 0.6614 (0.6); 0.6478 (0.6); 0.1995 (0.6); 0.1884 (0.7); 0.1753 (0.6); 0.0079 (0.6); - 0.0002 (17.3); -0.0085 (0.7) 1.78-14: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.4620 (1.8); 7.4600 (1.7); 7.3394 (2.0); 7.3260 (2.2); 7.2597 (30.9); 7.0245 (2.2); 7.0111 (2.0); 2.4301 (0.6); 2.4205 (0.7); 2.4109 (0.6); 2.1326 (6.6); 2.1307 (6.2); 1.8579 (16.0); 1.8387 (0.5); 1.5423 (4.4); 1.0516 (7.5); 0.9025 (7.6); 0.6808 (0.5); 0.6671 (0.6); 0.6614 (0.6); 0.6478 (0.6); 0.1995 (0.6); 0.1884 (0.7); 0.1753 (0.6); 0.0079 (0.6); - 0.0002 (17.3); -0.0085 (0.7) 1.78-14: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4446 (4.1); 7.4426 (3.9); 7.3574 (4.2); 7.3439 (4.5); 7.2602 (24.0); 7.0427 (4.6); 7.0293 (4.3); 6.9960 (0.7); 6.9888 (0.7); 5.2980 (4.1); 4.5417 (0.6); 4.5387 (0.6); 4.5335 (0.6); 4.5305 (0.6); 4.5247 (0.6); 4.5217 (0.6); 4.5165 (0.6); 4.5135 (0.6); 4.3870 (0.6); 4.3840 (0.6); 4.3788 (0.6); 4.3759 (0.6); 4.3700 (0.6); 4.3670 (0.6); 4.3618 (0.6); 4.3588 (0.6); 3.0299 (0.5); 3.0157 (0.6); 3.0128 (0.6); 3.0080 (0.6); 3.0051 (0.5); 2.9908 (0.6); 2.2566 (0.6); 2.2548 (0.6); 2.1380 (15.2); 2.1362 (14.3); 1.8314 (16.0); 1.8247 (15.9); 1.8126 (1.0); 1.8059 (0.9); 1.5616 (3.0); 1.3934 (0.5); 1.3852 (0.5); 1.3730 (0.6); 1.3690 (0.6); 1.3648 (0.7); 1.3608 (0.6); 1.3487 (0.6); 1.3405 (0.6); 1.3352 (0.6); 1.3270 (0.6); 1.3148 (0.6); 1.3108 (0.6); 1.3067 (0.7); 1.3027 (0.6); 1.2905 (0.6); 1.2823 (0.6); 0.8670 (0.5); 0.8529 (0.6); 0.8499 (0.7); 0.8467 (0.6); 0.8385 (0.7); 0.8360 (0.7); 0.8326 (0.7); 0.8296 (0.6); 0.8246 (0.7); 0.8215 (0.7);δ = 7.4446 (4.1); 7.4426 (3.9); 7.3574 (4.2); 7.3439 (4.5); 7.2602 (24.0); 7.0427 (4.6); 7.0293 (4.3); 6.9960 (0.7); 6,988 (0.7); 5.2980 (4.1); 4.5417 (0.6); 4.5387 (0.6); 4.5335 (0.6); 4.5305 (0.6); 4.5247 (0.6); 4.5217 (0.6); 4.5165 (0.6); 4.5135 (0.6); 4.3870 (0.6); 4.3840 (0.6); 4.3788 (0.6); 4.3759 (0.6); 4.3700 (0.6); 4.3670 (0.6); 4.3618 (0.6); 4.3588 (0.6); 3.0299 (0.5); 3.0157 (0.6); 3.0128 (0.6); 3.0080 (0.6); 3.0051 (0.5); 2.9908 (0.6); 2.2566 (0.6); 2.2548 (0.6); 2.1380 (15.2); 2.1362 (14.3); 1.8314 (16.0); 1.8247 (15.9); 1.8126 (1.0); 1.8059 (0.9); 1.5616 (3.0); 1.3934 (0.5); 1.3852 (0.5); 1.3730 (0.6); 1.3690 (0.6); 1.3648 (0.7); 1.3608 (0.6); 1.3487 (0.6); 1.3405 (0.6); 1.3352 (0.6); 1.3270 (0.6); 1.3148 (0.6); 1.3108 (0.6); 1.3067 (0.7); 1.3027 (0.6); 1.2905 (0.6); 1.2823 (0.6); 0.8670 (0.5); 0.8529 (0.6); 0.8499 (0.7); 0.8467 (0.6); 0.8385 (0.7); 0.8360 (0.7); 0.8326 (0.7); 0.8296 (0.6); 0.8246 (0.7); 0.8215 (0.7);

0.8182 (0.7); 0.8157 (0.6); 0.8075 (0.6); 0.8042 (0.6); 0.8012 (0.6); -0.0002 (9.5) 0.8182 (0.7); 0.8157 (0.6); 0.8075 (0.6); 0.8042 (0.6); 0.8012 (0.6); -0.0002 (9.5)

I.78-73: 1 H-NMR(400.0 MHz, CDCI3):  I.78-73: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5102 (1.8); 7.5082 (1.8); 7.4441 (1.9); 7.4353 (1.9); 7.3571 (2.1); 7.3437 (2.3); 7.2595 (60.7); 7.0533 (2.3); 7.0399 (2.1); 6.9642 (2.0); 6.9553 (1.9); 2.1769 (6.6); 2.1750 (6.3); 1.9679 (16.0); 1.9560 (0.8); 1.5383 (1.2); 0.0080δ = 7.5102 (1.8); 7.5082 (1.8); 7.4441 (1.9); 7.4353 (1.9); 7.3571 (2.1); 7.3437 (2.3); 7.2595 (60.7); 7.0533 (2.3); 7.0399 (2.1); 6.9642 (2.0); 6.9553 (1.9); 2.1769 (6.6); 2.1750 (6.3); 1.9679 (16.0); 1.9560 (0.8); 1.5383 (1.2); 0.0080

(1.2); -0.0002 (35.7); -0.0085 (1.2) (1.2); -0.0002 (35.7); -0.0085 (1.2)

1.78-136: 1 H-NMR(400.0 MHz, CDCI3):  1.78-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3290 (2.2); 7.3155 (3.1); 7.3138 (2.2); 7.3117 (2.0); 7.2598 (34.7); 7.0091 (2.4); 6.9956 (2.3); 5.2984 (1.6); 2.7593 (0.5); 2.1191 (6.8); 2.1173 (6.8); 1.8198 (16.0); 1.7930 (0.8); 1.5389 (6.7); 0.0080 (0.6); -0.0002 (20.2); -δ = 7.3290 (2.2); 7.3155 (3.1); 7.3138 (2.2); 7.3117 (2.0); 7.2598 (34.7); 7.0091 (2.4); 6.9956 (2.3); 5.2984 (1.6); 2.7593 (0.5); 2.1191 (6.8); 2.1173 (6.8); 1.8198 (16.0); 1.7930 (0.8); 1.5389 (6.7); 0.0080 (0.6); -0.0002 (20.2); -

0.0085 (0.9) 0.0085 (0.9)

1.78-137: 1 H-NMR(400.0 MHz, CDCI3):  1.78-137: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3285 (2.4); 7.3258 (2.0); 7.3152 (2.1); 7.2595 (71.6); 7.0089 (1.9); 6.9955 (2.2); 5.2986 (1.5); 2.1165 (6.4); 2.1149 (5.9); 1.8331 (16.0); 1.8170 (1.5); 1.8050 (1.2); 1.5332 (14.1); 0.0080 (1.1); -0.0002 (40.2); -0.0084 (2.5) 1.78-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3285 (2.4); 7.3258 (2.0); 7.3152 (2.1); 7.2595 (71.6); 7.0089 (1.9); 6.9955 (2.2); 5.2986 (1.5); 2.1165 (6.4); 2.1149 (5.9); 1.8331 (16.0); 1.8170 (1.5); 1.8050 (1.2); 1.5332 (14.1); 0.0080 (1.1); -0.0002 (40.2); -0.0084 (2.5) 1.78-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3274 (1.8); 7.3245 (2.7); 7.3109 (2.0); 7.2612 (9.0); 7.0042 (1.9); 6.9908 (1.8); 5.2982 (2.7); 2.1126 (6.0);δ = 7.3274 (1.8); 7.3245 (2.7); 7.3109 (2.0); 7.2612 (9.0); 7.0042 (1.9); 6.9908 (1.8); 5.2982 (2.7); 2.1126 (6.0);

2.1108 (5.9); 1.8271 (16.0); 1.8011 (0.7); -0.0002 (3.5) 2.1108 (5.9); 1.8271 (16.0); 1.8011 (0.7); -0.0002 (3.5)

1.78-170: 1 H-NMR(400.0 MHz, CDCI3):  1.78-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4940 (1.7); 7.4920 (1.6); 7.3420 (1.9); 7.3287 (2.1); 7.2601 (17.2); 7.0248 (2.1); 7.0114 (2.0); 3.9565 (2.7);δ = 7.4940 (1.7); 7.4920 (1.6); 7.3420 (1.9); 7.3287 (2.1); 7.2601 (17.2); 7.0248 (2.1); 7.0114 (2.0); 3.9565 (2.7);

3.9427 (2.7); 3.7059 (9.9); 2.1569 (6.2); 2.1551 (6.0); 1.8835 (16.0); -0.0002 (6.5) 3.9427 (2.7); 3.7059 (9.9); 2.1569 (6.2); 2.1551 (6.0); 1.8835 (16.0); -0.0002 (6.5)

1.78-211 : 1 H-NMR(400.0 MHz, CDCI3):  1.78-211: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4702 (1.8); 7.4683 (1.7); 7.3493 (1.7); 7.3359 (1.9); 7.2595 (36.2); 7.0383 (1.8); 7.0250 (1.7); 3.9809 (1.7); 3.9744 (1.8); 3.9679 (1.8); 3.9614 (1.8); 2.1805 (0.9); 2.1741 (1.7); 2.1676 (0.9); 2.1532 (6.4); 2.1514 (6.1); 1.8625δ = 7.4702 (1.8); 7.4683 (1.7); 7.3493 (1.7); 7.3359 (1.9); 7.2595 (36.2); 7.0383 (1.8); 7.0250 (1.7); 3.9809 (1.7); 3.9744 (1.8); 3.9679 (1.8); 3.9614 (1.8); 2.1805 (0.9); 2.1741 (1.7); 2.1676 (0.9); 2.1532 (6.4); 2.1514 (6.1); 1.8625

(16.0); 1.8480 (1.0); 1.5353 (6.3); 0.0078 (0.9); -0.0002 (21.5); -0.0084 (1.0) (16.0); 1.8480 (1.0); 1.5353 (6.3); 0.0078 (0.9); -0.0002 (21.5); -0.0084 (1.0)

I.78-284: 1 H-NMR(400.0 MHz, CDCI3):  I.78-284: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3197 (2.4); 7.3099 (2.2); 7.3077 (2.5); 7.3063 (3.5); 7.2597 (46.2); 7.0035 (2.6); 6.9900 (2.4); 5.2984 (0.9); 2.1107 (7.6); 2.1088 (7.5); 1.8262 (16.0); 1.8000 (0.8); 1.5380 (8.0); 0.0080 (0.8); -0.0002 (27.4); -0.0085 (1.1) I.78-323: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3197 (2.4); 7.3099 (2.2); 7.3077 (2.5); 7.3063 (3.5); 7.2597 (46.2); 7.0035 (2.6); 6.9900 (2.4); 5.2984 (0.9); 2.1107 (7.6); 2.1088 (7.5); 1.8262 (16.0); 1.8000 (0.8); 1.5380 (8.0); 0.0080 (0.8); -0.0002 (27.4); -0.0085 (1.1) I.78-323: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.0772 (0.5); 7.5183 (0.7); 7.4936 (1.8); 7.3401 (1.2); 7.3267 (1.4); 7.3099 (1.0); 7.2595 (124.0); 7.2098 (1.2); 7.0164 (1.4); 7.0031 (1.3); 6.9954 (0.8); 4.1483 (0.5); 4.1304 (1.6); 4.1125 (1.6); 4.0946 (0.5); 2.5111 (0.9); 2.1523 (5.4); 2.1087 (0.6); 2.0933 (1.3); 2.0432 (7.4); 2.0218 (6.7); 1.9022 (16.0); 1.8857 (1.5); 1.5490 (3.4); 1.2763 (2.1);δ = 9.0772 (0.5); 7.5183 (0.7); 7.4936 (1.8); 7.3401 (1.2); 7.3267 (1.4); 7.3099 (1.0); 7.2595 (124.0); 7.2098 (1.2); 7.0164 (1.4); 7.0031 (1.3); 6.9954 (0.8); 4.1483 (0.5); 4.1304 (1.6); 4.1125 (1.6); 4.0946 (0.5); 2.5111 (0.9); 2.1523 (5.4); 2.1087 (0.6); 2.0933 (1.3); 2.0432 (7.4); 2.0218 (6.7); 1.9022 (16.0); 1.8857 (1.5); 1.5490 (3.4); 1.2763 (2.1);

1.2584 (4.2); 1.2406 (2.1); 0.0080 (2.2); -0.0002 (68.2); -0.0085 (2.9); -0.0499 (0.6) 1.2584 (4.2); 1.2406 (2.1); 0.0080 (2.2); -0.0002 (68.2); -0.0085 (2.9); -0.0499 (0.6)

I.78-329: 1 H-NMR(400.0 MHz, CDCI3):  I.78-329: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4915 (2.0); 7.3343 (1.0); 7.3209 (1.0); 7.2599 (71.9); 7.0130 (1.0); 6.9995 (0.9); 6.9960 (0.7); 4.1483 (0.6); 4.1304 (2.0); 4.1126 (2.0); 4.0948 (0.7); 2.1477 (6.9); 2.0708 (0.7); 2.0434 (9.2); 1.9040 (16.0); 1.8893 (1.4); 1.5527 (4.1); 1.2764 (2.6); 1.2585 (5.3); 1.2406 (2.6); 1.0317 (1.3); 1.0240 (1.5); 1.0208 (1.4); 1.0134 (1.4); 1.0039 (0.5);δ = 7.4915 (2.0); 7.3343 (1.0); 7.3209 (1.0); 7.2599 (71.9); 7.0130 (1.0); 6.9995 (0.9); 6.9960 (0.7); 4.1483 (0.6); 4.1304 (2.0); 4.1126 (2.0); 4.0948 (0.7); 2.1477 (6.9); 2.0708 (0.7); 2.0434 (9.2); 1.9040 (16.0); 1.8893 (1.4); 1.5527 (4.1); 1.2764 (2.6); 1.2585 (5.3); 1.2406 (2.6); 1.0317 (1.3); 1.0240 (1.5); 1.0208 (1.4); 1.0134 (1.4); 1.0039 (0.5);

0.8314 (0.8); 0.8237 (1.0); 0.8119 (1.0); 0.8044 (0.8); 0.0080 (1.3); -0.0002 (41.2); -0.0085 (1.7) 0.8314 (0.8); 0.8237 (1.0); 0.8119 (1.0); 0.8044 (0.8); 0.0080 (1.3); -0.0002 (41.2); -0.0085 (1.7)

I.78-353: 1 H-NMR(400.0 MHz, CDCI3):  I.78-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.7948 (0.7); 7.4623 (1.8); 7.4603 (1.7); 7.3648 (1.9); 7.3514 (2.1); 7.2598 (37.2); 7.0508 (2.1); 7.0374 (1.9); 4.1304 (0.8); 4.1126 (0.8); 3.9114 (1.3); 3.9067 (0.6); 3.9031 (1.0); 3.9005 (1.5); 3.8969 (0.9); 3.8932 (0.6); 3.8892 (1.6); 3.6439 (0.8); 2.1588 (6.5); 2.1569 (6.2); 2.0433 (3.5); 1.8840 (16.0); 1.8697 (1.1); 1.5488 (2.5); 1.2763 (1.2);δ = 9.7948 (0.7); 7.4623 (1.8); 7.4603 (1.7); 7.3648 (1.9); 7.3514 (2.1); 7.2598 (37.2); 7.0508 (2.1); 7.0374 (1.9); 4.1304 (0.8); 4.1126 (0.8); 3.9114 (1.3); 3.9067 (0.6); 3.9031 (1.0); 3.9005 (1.5); 3.8969 (0.9); 3.8932 (0.6); 3.8892 (1.6); 3.6439 (0.8); 2.1588 (6.5); 2.1569 (6.2); 2.0433 (3.5); 1.8840 (16.0); 1.8697 (1.1); 1.5488 (2.5); 1.2763 (1.2);

1.2585 (2.2); 1.2406 (1.0); 0.8819 (0.8); 0.0079 (0.8); -0.0002 (19.2); -0.0085 (0.7) 1.2585 (2.2); 1.2406 (1.0); 0.8819 (0.8); 0.0079 (0.8); -0.0002 (19.2); -0.0085 (0.7)

1.80-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.80-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4062 (1.7); 7.4044 (1.6); 7.2596 (22.8); 7.2047 (0.7); 7.1955 (0.8); 7.1907 (0.8); 7.1816 (0.8); 6.8866 (1.4); 6.8726 (1.3); 2.6785 (0.6); 2.6693 (0.6); 2.1670 (3.2); 2.1655 (3.2); 2.1615 (3.3); 1.8173 (16.0); 1.5430 (5.4); 0.7221 (0.9); 0.7185 (1.3); 0.7045 (1.2); 0.7007 (1.0); 0.4086 (0.8); 0.4057 (1.0); 0.4022 (1.0); 0.3960 (1.0); 0.3925 (0.9);δ = 7.4062 (1.7); 7.4044 (1.6); 7.2596 (22.8); 7.2047 (0.7); 7.1955 (0.8); 7.1907 (0.8); 7.1816 (0.8); 6.8866 (1.4); 6.8726 (1.3); 2.6785 (0.6); 2.6693 (0.6); 2.1670 (3.2); 2.1655 (3.2); 2.1615 (3.3); 1.8173 (16.0); 1.5430 (5.4); 0.7221 (0.9); 0.7185 (1.3); 0.7045 (1.2); 0.7007 (1.0); 0.4086 (0.8); 0.4057 (1.0); 0.4022 (1.0); 0.3960 (1.0); 0.3925 (0.9);

0.0078 (0.5); -0.0002 (13.6); -0.0085 (0.5) 0.0078 (0.5); -0.0002 (13.6); -0.0085 (0.5)

1.80-19: 1 H-NMR(400.0 MHz, CDCI3):  1.80-19: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4132 (2.2); 7.4111 (2.2); 7.2599 (11.1); 7.2230 (1.2); 7.2137 (1.2); 7.2091 (1.3); 7.1997 (1.2); 6.9034 (1.7); 6.9025 (1.7); 6.8894 (1.6); 6.8885 (1.6); 3.0372 (0.7); 3.0287 (0.7); 2.1731 (4.0); 2.1713 (4.4); 2.1682 (4.3); 2.1663δ = 7.4132 (2.2); 7.4111 (2.2); 7.2599 (11.1); 7.2230 (1.2); 7.2137 (1.2); 7.2091 (1.3); 7.1997 (1.2); 6.9034 (1.7); 6.9025 (1.7); 6.8894 (1.6); 6.8885 (1.6); 3.0372 (0.7); 3.0287 (0.7); 2.1731 (4.0); 2.1713 (4.4); 2.1682 (4.3); 2.1663

(4.0); 1.8176 (16.0); 1.2160 (0.8); 1.1957 (0.8); -0.0002 (6.4) (4.0); 1.8176 (16.0); 1.2160 (0.8); 1.1957 (0.8); -0.0002 (6.4)

1.80-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.80-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.2950 (1.6); 7.2930 (1.6); 7.2598 (30.5); 7.1629 (0.8); 7.1538 (0.8); 7.1490 (0.8); 7.1399 (0.8); 6.8502 (1.1); 6.8491 (1.1); 6.8362 (1.0); 6.8352 (1.0); 5.2983 (1.6); 3.5252 (0.7); 2.6023 (0.8); 2.1550 (2.7); 2.1531 (2.8); 2.1485 (2.9); 2.1466 (2.7); 1.7982 (16.0); 1.7312 (0.9); 1.7214 (1.0); 1.7141 (2.7); 1.7066 (1.0); 1.6969 (1.0); 1.5462 (7.3); 0.0080 (0.7); -0.0002 (18.0); -0.0085 (0.6) 1.80-134: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.2950 (1.6); 7.2930 (1.6); 7.2598 (30.5); 7.1629 (0.8); 7.1538 (0.8); 7.1490 (0.8); 7.1399 (0.8); 6.8502 (1.1); 6.8491 (1.1); 6.8362 (1.0); 6.8352 (1.0); 5.2983 (1.6); 3.5252 (0.7); 2.6023 (0.8); 2.1550 (2.7); 2.1531 (2.8); 2.1485 (2.9); 2.1466 (2.7); 1.7982 (16.0); 1.7312 (0.9); 1.7214 (1.0); 1.7141 (2.7); 1.7066 (1.0); 1.6969 (1.0); 1.5462 (7.3); 0.0080 (0.7); -0.0002 (18.0); -0.0085 (0.6) 1.80-134: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.2657 (1.7); 7.2595 (45.2); 7.2463 (2.2); 7.2445 (2.1); 7.1666 (0.9); 7.1575 (1.0); 7.1526 (1.0); 7.1436 (1.0); 6.8521 (1.6); 6.8382 (1.4); 5.2981 (1.6); 2.6130 (0.6); 2.6065 (0.6); 2.5798 (1.0); 2.5752 (1.0); 2.5485 (0.6); 2.5420 (0.6); 2.1495 (3.6); 2.1480 (3.8); 2.1432 (3.9); 2.1418 (3.6); 1.7922 (16.0); 1.5393 (13.8); 0.8771 (3.6); 0.8611 (3.5);δ = 7.2657 (1.7); 7.2595 (45.2); 7.2463 (2.2); 7.2445 (2.1); 7.1666 (0.9); 7.1575 (1.0); 7.1526 (1.0); 7.1436 (1.0); 6.8521 (1.6); 6.8382 (1.4); 5.2981 (1.6); 2.6130 (0.6); 2.6065 (0.6); 2.5798 (1.0); 2.5752 (1.0); 2.5485 (0.6); 2.5420 (0.6); 2.1495 (3.6); 2.1480 (3.8); 2.1432 (3.9); 2.1418 (3.6); 1.7922 (16.0); 1.5393 (13.8); 0.8771 (3.6); 0.8611 (3.5);

0.0078 (0.8); 0.0062 (0.9); -0.0002 (24.6); -0.0083 (1.0) 0.0078 (0.8); 0.0062 (0.9); -0.0002 (24.6); -0.0083 (1.0)

1.80-136: 1 H-NMR(400.0 MHz, CDCI3):  1.80-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3449 (0.5); 7.2793 (3.8); 7.2594 (52.1); 7.1835 (0.6); 7.1745 (0.6); 7.1694 (0.6); 7.1604 (0.5); 6.8607 (1.1); 6.8467 (0.9); 5.2983 (2.0); 2.1613 (3.1); 2.1551 (2.8); 1.7963 (10.6); 1.5333 (16.0); -0.0002 (28.9); -0.0084 (1.2) 1.80-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3449 (0.5); 7.2793 (3.8); 7.2594 (52.1); 7.1835 (0.6); 7.1745 (0.6); 7.1694 (0.6); 7.1604 (0.5); 6.8607 (1.1); 6.8467 (0.9); 5.2983 (2.0); 2.1613 (3.1); 2.1551 (2.8); 1.7963 (10.6); 1.5333 (16.0); -0.0002 (28.9); -0.0084 (1.2) 1.80-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.2871 (1.6); 7.2852 (1.6); 7.2597 (26.7); 7.1781 (0.8); 7.1690 (0.8); 7.1642 (0.9); 7.1551 (0.8); 6.8568 (1.3); 6.8430 (1.2); 5.2981 (3.1); 2.1595 (2.9); 2.1579 (3.0); 2.1532 (3.1); 2.1515 (2.9); 1.8036 (16.0); 1.5634 (1.2); 0.0078δ = 7.2871 (1.6); 7.2852 (1.6); 7.2597 (26.7); 7.1.781 (0.8); 7.1690 (0.8); 7.1642 (0.9); 7.1551 (0.8); 6.8568 (1.3); 6.8430 (1.2); 5.2981 (3.1); 2.1595 (2.9); 2.1579 (3.0); 2.1532 (3.1); 2.1515 (2.9); 1.8036 (16.0); 1.5634 (1.2); 0.0078

(0.6); -0.0002 (14.7); -0.0084 (0.6) (0.6); -0.0002 (14.7); -0.0084 (0.6)

1.80-167: 1 H-NMR(400.0 MHz, CDCI3):  1.80-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.2667 (0.5); 7.2599 (14.5); 7.2518 (1.7); 7.2501 (1.6); 7.1659 (0.7); 7.1568 (0.7); 7.1520 (0.8); 7.1429 (0.7);δ = 7.2667 (0.5); 7.2599 (14.5); 7.2518 (1.7); 7.2501 (1.6); 7.1659 (0.7); 7.1568 (0.7); 7.1520 (0.8); 7.1429 (0.7);

6.8507 (1.3); 6.8368 (1.2); 2.1527 (3.0); 2.1474 (3.0); 1.8060 (16.0); 1.5508 (3.7); -0.0002 (8.2) 6.8507 (1.3); 6.8368 (1.2); 2.1527 (3.0); 2.1474 (3.0); 1.8060 (16.0); 1.5508 (3.7); -0.0002 (8.2)

1.80-211 : 1 H-NMR(400.0 MHz, CDCI3):  1.80-211: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4309 (1.6); 7.4288 (1.6); 7.2596 (17.2); 7.2090 (0.9); 7.1999 (0.9); 7.1951 (0.9); 7.1859 (0.9); 6.8865 (1.2); 6.8854 (1.2); 6.8726 (1.1); 6.8715 (1.1); 3.9699 (1.8); 3.9635 (1.9); 3.9568 (1.8); 3.9504 (1.8); 2.1873 (1.0); 2.1804δ = 7.4309 (1.6); 7.4288 (1.6); 7.2596 (17.2); 7.2090 (0.9); 7.1999 (0.9); 7.1951 (0.9); 7.1859 (0.9); 6.8865 (1.2); 6.8854 (1.2); 6.8726 (1.1); 6.8715 (1.1); 3.9699 (1.8); 3.9635 (1.9); 3.9568 (1.8); 3.9504 (1.8); 2.1873 (1.0); 2.1804

(3.6); 2.1781 (3.1); 2.1741 (3.6); 2.1720 (2.9); 1.8454 (16.0); 1.5446 (2.7); -0.0002 (9.8) (3.6); 2.1781 (3.1); 2.1741 (3.6); 2.1720 (2.9); 1.8454 (16.0); 1.5446 (2.7); -0.0002 (9.8)

1.80-284: 1 H-NMR(400.0 MHz, CDCI3):  1.80-284: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3449 (0.6); 7.2715 (4.1); 7.2593 (54.6); 7.1748 (0.6); 7.1640 (0.6); 7.1591 (0.6); 7.1501 (0.5); 6.8558 (0.5); 6.8418 (0.5); 5.2983 (0.6); 2.1535 (1.3); 2.1489 (1.4); 1.8034 (5.0); 1.5313 (16.0); 0.0079 (2.9); -0.0002 (31.3); -δ = 7.3449 (0.6); 7.2715 (4.1); 7.2593 (54.6); 7.1748 (0.6); 7.1640 (0.6); 7.1591 (0.6); 7.1501 (0.5); 6.8558 (0.5); 6.8418 (0.5); 5.2983 (0.6); 2.1535 (1.3); 2.1489 (1.4); 1.8034 (5.0); 1.5313 (16.0); 0.0079 (2.9); -0.0002 (31.3); -

0.0085 (3.1) 0.0085 (3.1)

1.80-323: 1 H-NMR(400.0 MHz, CDCI3):  1.80-323: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5183 (1.0); 7.4548 (1.6); 7.3088 (0.5); 7.2594 (181.2); 7.2265 (1.0); 7.2099 (0.7); 7.2037 (0.8); 7.1941 (0.8); 7.1893 (0.8); 7.1804 (0.7); 6.9954 (1.0); 6.8657 (1.0); 6.8524 (0.9); 4.1305 (0.7); 4.1126 (0.7); 2.5071 (0.9); 2.1762 (2.6); 2.1710 (2.7); 2.0784 (1.2); 2.0434 (3.5); 2.0241 (6.3); 2.0045 (0.5); 1.9217 (0.5); 1.8848 (16.0); 1.5367 (9.5); 1.2764 (1.0); 1.2586 (2.1); 1.2407 (1.0); 0.0080 (2.8); -0.0002 (100.7); -0.0085 (4.3) δ = 7.5183 (1.0); 7.4548 (1.6); 7.3088 (0.5); 7.2594 (181.2); 7.2265 (1.0); 7.2099 (0.7); 7.2037 (0.8); 7.1941 (0.8); 7.1893 (0.8); 7.1804 (0.7); 6.9954 (1.0); 6.8657 (1.0); 6.8524 (0.9); 4.1305 (0.7); 4.1126 (0.7); 2.5071 (0.9); 2.1762 (2.6); 2.1710 (2.7); 2.0784 (1.2); 2.0434 (3.5); 2.0241 (6.3); 2.0045 (0.5); 1.9217 (0.5); 1.8848 (16.0); 1.5367 (9.5); 1.2764 (1.0); 1.2586 (2.1); 1.2407 (1.0); 0.0080 (2.8); -0.0002 (100.7); -0.0085 (4.3)

1.80- 73: 1 H-NMR(400.0 MHz, CDCI3):  1.80-73: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4734 (1.7); 7.4714 (1.7); 7.4497 (1.6); 7.4408 (1.6); 7.2592 (82.7); 7.2228 (0.8); 7.2137 (0.9); 7.2089 (1.1); 7.1998 (0.9); 6.9681 (1.6); 6.9592 (1.6); 6.8975 (1.3); 6.8964 (1.3); 6.8835 (1.2); 6.8825 (1.2); 5.2981 (1.7); 2.1955δ = 7.4734 (1.7); 7.4714 (1.7); 7.4497 (1.6); 7.4408 (1.6); 7.2592 (82.7); 7.2228 (0.8); 7.2137 (0.9); 7.2089 (1.1); 7.1998 (0.9); 6.9681 (1.6); 6.9592 (1.6); 6.8975 (1.3); 6.8964 (1.3); 6.8835 (1.2); 6.8825 (1.2); 5.2981 (1.7); 2.1955

(3.0) ; 2.1936 (3.2); 2.1892 (3.2); 2.1873 (3.0); 1.9520 (16.0); 1.5370 (2.0); 0.0079 (1.9); -0.0002 (47.8); -0.0085 (1.7)(3.0); 2.1936 (3.2); 2.1892 (3.2); 2.1873 (3.0); 1.9520 (16.0); 1.5370 (2.0); 0.0079 (1.9); -0.0002 (47.8); -0.0085 (1.7)

1.81- 1 : 1 H-NMR(400.0 MHz, CDCI3): 1.81-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 7.4482 (1.7); 7.4462 (1.6); 7.3466 (1.9); 7.3332 (2.1); 7.2603 (17.5); 7.0339 (2.1); 7.0206 (1.9); 2.6696 (0.6);δ = 7.4482 (1.7); 7.4462 (1.6); 7.3466 (1.9); 7.3332 (2.1); 7.2603 (17.5); 7.0339 (2.1); 7.0206 (1.9); 2.6696 (0.6);

2.6606 (0.6); 2.1346 (6.3); 2.1327 (6.0); 1.8370 (16.0); 0.7136 (0.8); 0.7101 (1.2); 0.7073 (0.6); 0.6972 (0.9); 0.69602.6606 (0.6); 2.1346 (6.3); 2.1327 (6.0); 1.8370 (16.0); 0.7136 (0.8); 0.7101 (1.2); 0.7073 (0.6); 0.6972 (0.9); 0.6960

(1.1) ; 0.6922 (0.9); 0.4063 (0.8); 0.4033 (0.9); 0.3999 (0.9); 0.3974 (0.8); 0.3936 (0.9); 0.3901 (0.8); -0.0002 (6.7) 1.81-1 : 1 H-NMR(400.0 MHz, CDCI3): (1.1); 0.6922 (0.9); 0.4063 (0.8); 0.4033 (0.9); 0.3999 (0.9); 0.3974 (0.8); 0.3936 (0.9); 0.3901 (0.8); -0.0002 (6.7) 1.81-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.4484 (1.6); 7.4464 (1.6); 7.3467 (2.2); 7.3333 (2.3); 7.2603 (18.5); 7.0339 (2.3); 7.0205 (2.2); 2.6696 (0.6);δ = 7.4484 (1.6); 7.4464 (1.6); 7.3467 (2.2); 7.3333 (2.3); 7.2603 (18.5); 7.0339 (2.3); 7.0205 (2.2); 2.6696 (0.6);

2.6607 (0.6); 2.1347 (6.1); 2.1327 (6.2); 1.8372 (16.0); 1.8102 (0.9); 0.7154 (0.5); 0.7134 (0.8); 0.7099 (1.3); 0.7071 (0.6); 0.6972 (0.9); 0.6958 (1.1); 0.6920 (1.0); 0.6891 (0.6); 0.4064 (0.8); 0.4035 (0.9); 0.4000 (0.8); 0.3974 (0.7);2.6607 (0.6); 2.1347 (6.1); 2.1327 (6.2); 1.8372 (16.0); 1.8102 (0.9); 0.7154 (0.5); 0.7134 (0.8); 0.7099 (1.3); 0.7071 (0.6); 0.6972 (0.9); 0.6958 (1.1); 0.6920 (1.0); 0.6891 (0.6); 0.4064 (0.8); 0.4035 (0.9); 0.4000 (0.8); 0.3974 (0.7);

0.3938 (0.9); 0.3903 (0.9); -0.0002 (7.4) 0.3938 (0.9); 0.3903 (0.9); -0.0002 (7.4)

1.81-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.81-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3417 (1.6); 7.3397 (1.6); 7.3105 (2.0); 7.2971 (2.1); 7.2608 (15.8); 6.9967 (2.2); 6.9833 (2.0); 3.5224 (0.8); 2.6162 (0.8); 2.1076 (5.9); 2.1057 (5.8); 1.8180 (16.0); 1.7349 (1.1); 1.7253 (1.0); 1.7177 (2.8); 1.7102 (1.0); 1.7005δ = 7.3417 (1.6); 7.3397 (1.6); 7.3105 (2.0); 7.2971 (2.1); 7.2608 (15.8); 6.9967 (2.2); 6.9833 (2.0); 3.5224 (0.8); 2.6162 (0.8); 2.1076 (5.9); 2.1057 (5.8); 1.8180 (16.0); 1.7349 (1.1); 1.7253 (1.0); 1.7177 (2.8); 1.7102 (1.0); 1.7005

(0.8); -0.0002 (6.3) (0.8); -0.0002 (6.3)

1.81-167: 1 H-NMR(400.0 MHz, CDCI3):  1.81-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3108 (1.8); 7.2973 (2.3); 7.2948 (1.6); 7.2927 (1.5); 7.2602 (19.3); 6.9978 (2.0); 6.9844 (1.8); 2.1127 (5.5);δ = 7.3108 (1.8); 7.2973 (2.3); 7.2948 (1.6); 7.2927 (1.5); 7.2602 (19.3); 6.9978 (2.0); 6.9844 (1.8); 2.1127 (5.5);

2.1108 (5.6); 1.8242 (16.0); -0.0002 (7.4) 2.1108 (5.6); 1.8242 (16.0); -0.0002 (7.4)

1.81-172: 1 H-NMR(400.0 MHz, CDCI3):  1.81-172: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4861 (2.4); 7.4840 (2.4); 7.3409 (2.9); 7.3275 (3.1); 7.2602 (25.4); 7.0228 (3.4); 7.0094 (3.1); 4.4694 (0.9); 4.4513 (1.4); 4.4332 (0.9); 3.6896 (16.0); 2.1532 (8.8); 2.1513 (8.6); 1.8693 (8.6); 1.8604 (8.5); 1.3432 (6.5); 1.3251 (6.4); -0.0002 (9.8) δ = 7.4861 (2.4); 7.4840 (2.4); 7.3409 (2.9); 7.3275 (3.1); 7.2602 (25.4); 7.0228 (3.4); 7.0094 (3.1); 4.4694 (0.9); 4.4513 (1.4); 4.4332 (0.9); 3.6896 (16.0); 2.1532 (8.8); 2.1513 (8.6); 1.8693 (8.6); 1.8604 (8.5); 1.3432 (6.5); 1.3251 (6.4); -0.0002 (9.8)

1.81- 178: 1 H-NMR(400.0 MHz, CDCI3):  1.81-178: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4546 (1.7); 7.4526 (1.6); 7.3379 (2.0); 7.3245 (2.2); 7.2606 (16.1); 7.0259 (2.3); 7.0125 (2.0); 3.5924 (10.5); 3.4679 (0.7); 3.4522 (1.7); 3.4366 (1.7); 3.4208 (0.7); 2.4919 (1.3); 2.4759 (2.4); 2.4598 (1.2); 2.1505 (6.3); 2.1486 (6.1); 1.8429 (16.0); 1.5617 (1.1); -0.0002 (6.2) δ = 7.4546 (1.7); 7.4526 (1.6); 7.3379 (2.0); 7.3245 (2.2); 7.2606 (16.1); 7.0259 (2.3); 7.0125 (2.0); 3.5924 (10.5); 3.4679 (0.7); 3.4522 (1.7); 3.4366 (1.7); 3.4208 (0.7); 2.4919 (1.3); 2.4759 (2.4); 2.4598 (1.2); 2.1505 (6.3); 2.1486 (6.1); 1.8429 (16.0); 1.5617 (1.1); -0.0002 (6.2)

1.82- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.82-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 8.9687 (1.5); 8.9636 (1.5); 7.6129 (1.6); 7.6077 (1.6); 7.4333 (1.5); 7.4315 (1.5); 7.2605 (34.8); 2.6213 (0.6); 2.6130 (0.6); 2.3373 (7.0); 2.3355 (6.9); 1.8514 (16.0); 0.6963 (1.0); 0.6929 (1.4); 0.6787 (1.3); 0.6750 (1.1); 0.6722δ = 8.9687 (1.5); 8.9636 (1.5); 7.6129 (1.6); 7.6077 (1.6); 7.4333 (1.5); 7.4315 (1.5); 7.2605 (34.8); 2.6213 (0.6); 2.6130 (0.6); 2.3373 (7.0); 2.3355 (6.9); 1.8514 (16.0); 0.6963 (1.0); 0.6929 (1.4); 0.6787 (1.3); 0.6750 (1.1); 0.6722

(0.5); 0.3619 (0.9); 0.3589 (1.1); 0.3554 (1.0); 0.3528 (0.9); 0.3492 (1.0); 0.3458 (1.0); -0.0002 (13.8) (0.5); 0.3619 (0.9); 0.3589 (1.1); 0.3554 (1.0); 0.3528 (0.9); 0.3492 (1.0); 0.3458 (1.0); -0.0002 (13.8)

1.82-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.82-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9062 (1.6); 8.9010 (1.6); 7.6226 (1.9); 7.6175 (1.9); 7.3156 (1.7); 7.3136 (1.7); 7.2603 (43.4); 3.5324 (0.9); 2.6376 (0.9); 2.3443 (6.5); 2.3424 (6.4); 1.8275 (16.0); 1.7018 (1.2); 1.6922 (1.2); 1.6847 (1.3); 0.0080 (0.5); -0.0002 (16.8) 1.82-167: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.9062 (1.6); 8.9010 (1.6); 7.6226 (1.9); 7.6175 (1.9); 7.3156 (1.7); 7.3136 (1.7); 7.2603 (43.4); 3.5324 (0.9); 2.6376 (0.9); 2.3443 (6.5); 2.3424 (6.4); 1.8275 (16.0); 1.7018 (1.2); 1.6922 (1.2); 1.6847 (1.3); 0.0080 (0.5); -0.0002 (16.8) 1.82-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9297 (1.4); 8.9246 (1.4); 7.6126 (1.8); 7.6075 (1.8); 7.2759 (2.0); 7.2739 (2.0); 7.2600 (69.3); 2.3363 (7.1);δ = 8.9297 (1.4); 8.9246 (1.4); 7.6126 (1.8); 7.6075 (1.8); 7.2759 (2.0); 7.2739 (2.0); 7.2600 (69.3); 2.3363 (7.1);

2.3344 (7.1); 1.8363 (16.0); 0.0079 (0.8); -0.0002 (26.3); -0.0085 (0.7) 2.3344 (7.1); 1.8363 (16.0); 0.0079 (0.8); -0.0002 (26.3); -0.0085 (0.7)

1.82-170: 1 H-NMR(400.0 MHz, CDCI3):  1.82-170: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9645 (1.3); 8.9594 (1.4); 7.7384 (1.4); 7.7332 (1.4); 7.4875 (1.5); 7.4859 (1.5); 7.2651 (0.5); 7.2642 (0.8); 7.2602 (46.0); 7.2554 (1.3); 7.2546 (1.1); 7.2530 (0.7); 7.2521 (0.6); 7.2513 (0.6); 7.2506 (0.5); 7.2497 (0.5); 3.9553δ = 8.9645 (1.3); 8.9594 (1.4); 7.7384 (1.4); 7.7332 (1.4); 7.4875 (1.5); 7.4859 (1.5); 7.2651 (0.5); 7.2642 (0.8); 7.2602 (46.0); 7.2554 (1.3); 7.2546 (1.1); 7.2530 (0.7); 7.2521 (0.6); 7.2513 (0.6); 7.2506 (0.5); 7.2497 (0.5); 3.9553

(2.5) ; 3.9421 (2.5); 3.6959 (11.8); 2.3509 (7.7); 2.3490 (7.8); 1.8928 (16.0); 0.0079 (0.5); -0.0002 (17.7); -0.0051(2.5); 3.9421 (2.5); 3.6959 (11.8); 2.3509 (7.7); 2.3490 (7.8); 1.8928 (16.0); 0.0079 (0.5); -0.0002 (17.7); -0.0051

(0.5); -0.0085 (0.7) (0.5); -0.0085 (0.7)

1.82-171 : 1 H-NMR(400.0 MHz, CDCI3):  1.82-171: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9083 (3.0); 8.9032 (3.0); 7.6341 (4.7); 7.6290 (4.6); 7.5183 (3.0); 7.4218 (1.8); 7.3101 (0.7); 7.2928 (0.6); 7.2595 (521.6); 7.2286 (0.8); 7.2092 (0.9); 6.9955 (3.0); 4.0658 (3.6); 3.7592 (5.9); 2.5626 (5.8); 2.3540 (7.1); 1.8584δ = 8.9083 (3.0); 8.9032 (3.0); 7.6341 (4.7); 7.6290 (4.6); 7.5183 (3.0); 7.4218 (1.8); 7.3101 (0.7); 7.2928 (0.6); 7.2595 (521.6); 7.2286 (0.8); 7.2092 (0.9); 6.9955 (3.0); 4.0658 (3.6); 3.7592 (5.9); 2.5626 (5.8); 2.3540 (7.1); 1.8584

(16.0); 1.6242 (7.8); 0.1462 (0.6); 0.0080 (6.1); -0.0002 (199.9); -0.0086 (5.4); -0.1496 (0.6) (16.0); 1.6242 (7.8); 0.1462 (0.6); 0.0080 (6.1); -0.0002 (199.9); -0.0086 (5.4); -0.1496 (0.6)

1.82-172: 1 H-NMR(400.0 MHz, CDCI3):  1.82-172: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9458 (2.2); 8.9406 (2.2); 7.7522 (2.3); 7.7470 (2.3); 7.4680 (2.2); 7.4661 (2.1); 7.2605 (41.1); 4.4724 (0.9); 4.4546 (1.3); 4.4368 (0.9); 3.6820 (16.0); 2.3581 (8.7); 2.3562 (8.4); 1.8744 (8.6); 1.8662 (8.6); 1.3306 (6.5); 1.3127δ = 8.9458 (2.2); 8.9406 (2.2); 7.7522 (2.3); 7.7470 (2.3); 7.4680 (2.2); 7.4661 (2.1); 7.2605 (41.1); 4.4724 (0.9); 4.4546 (1.3); 4.4368 (0.9); 3.6820 (16.0); 2.3581 (8.7); 2.3562 (8.4); 1.8744 (8.6); 1.8662 (8.6); 1.3306 (6.5); 1.3127

(6.4); -0.0002 (16.1) (6.4); -0.0002 (16.1)

1.82-178: 1 H-NMR(400.0 MHz, CDCI3):  1.82-178: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.9155 (1.6); 8.9103 (1.7); 7.7390 (1.8); 7.7339 (1.7); 7.4401 (1.8); 7.4384 (1.7); 7.2608 (26.6); 3.5301 (11.4); 3.4562 (0.7); 3.4410 (1.7); 3.4255 (1.8); 3.4101 (0.7); 2.4720 (1.4); 2.4565 (2.3); 2.4411 (1.4); 2.3556 (7.0); 2.3539δ = 8.9155 (1.6); 8.9103 (1.7); 7.7390 (1.8); 7.7339 (1.7); 7.4401 (1.8); 7.4384 (1.7); 7.2608 (26.6); 3.5301 (11.4); 3.4562 (0.7); 3.4410 (1.7); 3.4255 (1.8); 3.4101 (0.7); 2.4720 (1.4); 2.4565 (2.3); 2.4411 (1.4); 2.3556 (7.0); 2.3539

(6.6) ; 1.8547 (16.0); -0.0002 (10.0) (6.6); 1.8547 (16.0); -0.0002 (10.0)

I.82-303: 1 H-NMR(400.0 MHz, CDCI3):  I.82-303: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.8831 (1.1); 8.8780 (1.1); 7.6484 (1.6); 7.6435 (1.6); 7.5183 (1.2); 7.3800 (1.8); 7.3780 (1.7); 7.3098 (0.6); 7.2594 (200.0); 6.9954 (1.2); 3.1536 (6.6); 2.9801 (4.2); 2.3622 (6.8); 2.3604 (6.6); 1.8316 (16.0); 1.6564 (2.6);δ = 8.8831 (1.1); 8.8780 (1.1); 7.6484 (1.6); 7.6435 (1.6); 7.5183 (1.2); 7.3800 (1.8); 7.3780 (1.7); 7.3098 (0.6); 7.2594 (200.0); 6.9954 (1.2); 3.1536 (6.6); 2.9801 (4.2); 2.3622 (6.8); 2.3604 (6.6); 1.8316 (16.0); 1.6564 (2.6);

0.0079 (2.4); -0.0002 (75.1); -0.0085 (2.1) 0.0079 (2.4); -0.0002 (75.1); -0.0085 (2.1)

I.82-329: 1 H-NMR(400.0 MHz, CDCI3):  I.82-329: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.4528 (1.8); 7.2594 (167.4); 7.2080 (1.4); 6.9955 (0.8); 6.8614 (1.2); 6.8479 (0.9); 4.1305 (2.0); 4.1126 (2.0); 4.0947 (0.8); 2.1713 (3.0); 2.1655 (2.8); 2.1234 (0.9); 2.0432 (8.6); 1.8875 (16.0); 1.5525 (7.3); 1.2763 (2.9); 1.2585δ = 7.4528 (1.8); 7.2594 (167.4); 7.2080 (1.4); 6.9955 (0.8); 6.8614 (1.2); 6.8479 (0.9); 4.1305 (2.0); 4.1126 (2.0); 4.0947 (0.8); 2.1713 (3.0); 2.1655 (2.8); 2.1234 (0.9); 2.0432 (8.6); 1.8875 (16.0); 1.5525 (7.3); 1.2763 (2.9); 1.2585

(5.4) ; 1.2406 (2.6); 1.0288 (1.3); 0.8128 (0.9); 0.0080 (3.4); -0.0002 (91.7); -0.0085 (2.4) (5.4); 1.2406 (2.6); 1.0288 (1.3); 0.8128 (0.9); 0.0080 (3.4); -0.0002 (91.7); -0.0085 (2.4)

1.84-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.84-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.8485 (3.7); 8.8363 (3.9); 7.4812 (1.7); 7.4791 (1.7); 7.2621 (24.3); 7.2118 (1.2); 7.1997 (2.2); 7.1875 (1.1); 2.8945 (0.9); 2.6116 (0.6); 2.6035 (0.6); 2.4388 (6.2); 2.4369 (6.2); 1.9200 (0.6); 1.9026 (16.0); 0.6803 (0.8); 0.6768 (1.3); 0.6740 (0.6); 0.6626 (1.2); 0.6589 (1.0); 0.6560 (0.6); 0.3642 (0.8); 0.3612 (0.9); 0.3578 (0.9); 0.3551 (0.8);δ = 8.8485 (3.7); 8.8363 (3.9); 7.4812 (1.7); 7.4791 (1.7); 7.2621 (24.3); 7.2118 (1.2); 7.1997 (2.2); 7.1875 (1.1); 2.8945 (0.9); 2.6116 (0.6); 2.6035 (0.6); 2.4388 (6.2); 2.4369 (6.2); 1.9200 (0.6); 1.9026 (16.0); 0.6803 (0.8); 0.6768 (1.3); 0.6740 (0.6); 0.6626 (1.2); 0.6589 (1.0); 0.6560 (0.6); 0.3642 (0.8); 0.3612 (0.9); 0.3578 (0.9); 0.3551 (0.8);

0.3515 (1.0); 0.3481 (0.9); -0.0002 (9.0) 0.3515 (1.0); 0.3481 (0.9); -0.0002 (9.0)

1.84-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.84-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.7942 (3.8); 8.7819 (3.9); 7.3536 (1.8); 7.3515 (1.7); 7.2622 (30.3); 7.2573 (0.8); 7.2565 (0.7); 7.2557 (0.6); 7.2549 (0.5); 7.1693 (1.2); 7.1571 (2.2); 7.1448 (1.1); 5.2989 (0.5); 3.5299 (0.8); 2.8828 (2.3); 2.6710 (0.9); 2.4374 (6.1); 2.4354 (6.0); 2.0940 (0.6); 1.9256 (0.9); 1.8875 (16.0); 1.6946 (1.0); 1.6896 (1.0); 1.6833 (0.8); 1.6790 (0.9);δ = 8.7942 (3.8); 8.7819 (3.9); 7.3536 (1.8); 7.3515 (1.7); 7.2622 (30.3); 7.2573 (0.8); 7.2565 (0.7); 7.2557 (0.6); 7.2549 (0.5); 7.1693 (1.2); 7.1571 (2.2); 7.1448 (1.1); 5.2989 (0.5); 3.5299 (0.8); 2.8828 (2.3); 2.6710 (0.9); 2.4374 (6.1); 2.4354 (6.0); 2.0940 (0.6); 1.9256 (0.9); 1.8875 (16.0); 1.6946 (1.0); 1.6896 (1.0); 1.6833 (0.8); 1.6790 (0.9);

1.2562 (0.8); 1.1249 (0.6); -0.0002 (10.8) 1.2562 (0.8); 1.1249 (0.6); -0.0002 (10.8)

1.84-213: 1 H-NMR(400.0 MHz, CDCI3):  1.84-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.8522 (3.3); 8.8399 (3.3); 7.5194 (2.1); 7.2602 (84.9); 7.2384 (1.0); 7.2262 (1.8); 7.2139 (1.0); 4.2620 (1.2); 4.2470 (1.3); 4.0891 (3.3); 4.0746 (3.3); 2.8962 (1.9); 2.4452 (6.5); 2.0639 (0.6); 1.9347 (16.0); 1.9184 (1.9); 1.5856δ = 8.8522 (3.3); 8.8399 (3.3); 7.5194 (2.1); 7.2602 (84.9); 7.2384 (1.0); 7.2262 (1.8); 7.2139 (1.0); 4.2620 (1.2); 4.2470 (1.3); 4.0891 (3.3); 4.0746 (3.3); 2.8962 (1.9); 2.4452 (6.5); 2.0639 (0.6); 1.9347 (16.0); 1.9184 (1.9); 1.5856

(1.3); 1.4866 (0.7); 1.2552 (0.6); 1.1427 (0.7); 1.0080 (0.6); 0.0079 (0.8); -0.0002 (29.8); -0.0083 (1.1) (1.3); 1.4866 (0.7); 1.2552 (0.6); 1.1427 (0.7); 1.0080 (0.6); 0.0079 (0.8); -0.0002 (29.8); -0.0083 (1.1)

1.113-152: 1 H-NMR(400.0 MHz, CDCI3):  1.113-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3173 (0.8); 7.2601 (22.2); 7.2259 (3.5); 6.9759 (1.0); 6.9573 (1.2); 6.9552 (1.2); 6.9367 (0.9); 3.7588 (10.4);δ = 7.3173 (0.8); 7.2601 (22.2); 7.2259 (3.5); 6.9759 (1.0); 6.9573 (1.2); 6.9552 (1.2); 6.9367 (0.9); 3.7588 (10.4);

1.8375 (16.0); 1.5452 (10.4); -0.0002 (13.0); -0.0082 (0.6) 1.8375 (16.0); 1.5452 (10.4); -0.0002 (13.0); -0.0082 (0.6)

1.113-353: 1 H-NMR(400.0 MHz, CDCI3):  1.113-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3622 (0.8); 7.3569 (0.9); 7.3483 (4.2); 7.3359 (0.5); 7.2599 (45.3); 7.0194 (1.1); 7.0002 (1.3); 6.9986 (1.2); 6.9961 (0.8); 6.9795 (0.9); 3.9082 (1.3); 3.9036 (0.5); 3.8999 (0.9); 3.8973 (1.4); 3.8938 (0.9); 3.8901 (0.6); 3.8861δ = 9.3622 (0.8); 7.3569 (0.9); 7.3483 (4.2); 7.3359 (0.5); 7.2599 (45.3); 7.0194 (1.1); 7,0002 (1.3); 6.9986 (1.2); 6.9961 (0.8); 6.9795 (0.9); 3.9082 (1.3); 3.9036 (0.5); 3.8999 (0.9); 3.8973 (1.4); 3.8938 (0.9); 3.8901 (0.6); 3.8861

(1.5) ; 3.7926 (12.4); 3.6458 (0.8); 3.6350 (0.9); 3.6245 (0.6); 1.8985 (16.0); 1.5483 (2.7); 0.0079 (0.9); -0.0002(1.5); 3.7926 (12.4); 3.6458 (0.8); 3.6350 (0.9); 3.6245 (0.6); 1.8985 (16.0); 1.5483 (2.7); 0.0079 (0.9); -0.0002

(26.3); -0.0085 (0.8) (26.3); -0.0085 (0.8)

1.115-152: 1 H-NMR(400.0 MHz, CDCI3):  1.115-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3043 (0.7); 7.2913 (0.9); 7.2847 (1.9); 7.2789 (1.2); 7.2762 (2.1); 7.2601 (34.1); 7.2220 (4.0); 7.0810 (0.5); 7.0620 (0.5); 7.0592 (0.6); 5.2983 (0.7); 3.7445 (11.8); 1.8373 (16.0); 1.5456 (3.7); -0.0002 (12.2) δ = 7.3043 (0.7); 7.2913 (0.9); 7.2847 (1.9); 7.2789 (1.2); 7.2762 (2.1); 7.2601 (34.1); 7.2220 (4.0); 7.0810 (0.5); 7.0620 (0.5); 7: 0592 (0.6); 5.2983 (0.7); 3.7445 (11.8); 1.8373 (16.0); 1.5456 (3.7); -0.0002 (12.2)

1.115- 353: 1 H-NMR(400.0 MHz, CDCI3):  1.115-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.3137 (0.9); 7.3578 (3.8); 7.3488 (0.8); 7.3351 (0.8); 7.3291 (1.0); 7.3251 (1.5); 7.3187 (2.2); 7.2601 (30.4); 7.1261 (0.6); 7.1217 (0.5); 7.1067 (0.5); 7.1035 (0.7); 3.8894 (1.4); 3.8787 (1.6); 3.8751 (0.9); 3.8674 (1.6); 3.7769 (11.3); 3.7395 (0.9); 3.6407 (0.8); 3.6307 (1.0); 3.6198 (0.7); 1.9058 (16.0); 1.5620 (0.9); -0.0002 (10.4) δ = 9.3137 (0.9); 7.3578 (3.8); 7.3488 (0.8); 7.3351 (0.8); 7.3291 (1.0); 7.3251 (1.5); 7.3187 (2.2); 7.2601 (30.4); 7.1261 (0.6); 7.1217 (0.5); 7.1067 (0.5); 7.1035 (0.7); 3.8894 (1.4); 3.8787 (1.6); 3.8751 (0.9); 3.8674 (1.6); 3.7769 (11.3); 3.7395 (0.9); 3.6407 (0.8); 3.6307 (1.0); 3.6198 (0.7); 1.9058 (16.0); 1.5620 (0.9); -0.0002 (10.4)

1.116- 1 : 1 H-NMR(400.0 MHz, d6-DMSO):  1,116-1: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7149 (2.0); 7.4498 (0.6); 3.7157 (6.0); 3.3099 (16.0); 2.5183 (0.6); 2.5097 (5.4); 2.5051 (11.0); 2.5005 (15.1); 2.4959 (10.4); 2.4913 (4.6); 1.6874 (6.1); 0.6082 (0.5); 0.6026 (0.7); 0.5904 (0.7); 0.5846 (0.5); 0.4207 (0.6); 0.4146δ = 7.7149 (2.0); 7.4498 (0.6); 3.7157 (6.0); 3.3099 (16.0); 2.5183 (0.6); 2.5097 (5.4); 2.5051 (11.0); 2.5005 (15.1); 2.4959 (10.4); 2.4913 (4.6); 1.6874 (6.1); 0.6082 (0.5); 0.6026 (0.7); 0.5904 (0.7); 0.5846 (0.5); 0.4207 (0.6); 0.4146

(0.6); 0.4104 (0.5); 0.4048 (0.5); -0.0002 (3.2) (0.6); 0.4104 (0.5); 0.4048 (0.5); -0.0002 (3.2)

1.116-101 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-101: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8036 (1.3); 3.7168 (4.0); 3.3096 (16.0); 2.5184 (0.6); 2.5097 (5.3); 2.5052 (10.9); 2.5006 (14.9); 2.4960 (10.3); 2.4914 (4.6); 1.6890 (4.8); -0.0002 (3.2) 1.116-136: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 7.8036 (1.3); 3.7168 (4.0); 3.3096 (16.0); 2.5184 (0.6); 2.5097 (5.3); 2.5052 (10.9); 2.5006 (14.9); 2.4960 (10.3); 2.4914 (4.6); 1.6890 (4.8); -0.0002 (3.2) 1.116-136: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8255 (1.9); 7.4625 (0.5); 3.7317 (5.6); 3.3094 (16.0); 2.8899 (1.2); 2.7316 (1.0); 2.7303 (1.0); 2.5184 (0.7);δ = 7.8255 (1.9); 7.4625 (0.5); 3.7317 (5.6); 3.3094 (16.0); 2.8899 (1.2); 2.7316 (1.0); 2.7303 (1.0); 2.5184 (0.7);

2.5097 (6.1); 2.5051 (12.5); 2.5006 (16.9); 2.4960 (11.6); 2.4914 (5.1); 1.6906 (6.4); -0.0002 (3.4) 2.5097 (6.1); 2.5051 (12.5); 2.5006 (16.9); 2.4960 (11.6); 2.4914 (5.1); 1.6906 (6.4); -0.0002 (3.4)

1.116-137: 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-137: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.4749 (0.5); 8.4634 (0.5); 7.8672 (2.0); 7.4607 (0.6); 3.7328 (6.1); 3.7191 (1.0); 3.3092 (16.0); 2.5232 (0.6); 2.5186 (0.8); 2.5099 (6.6); 2.5053 (13.4); 2.5007 (18.2); 2.4961 (12.4); 2.4916 (5.4); 1.7826 (0.5); 1.7746 (1.3);δ = 8.4749 (0.5); 8.4634 (0.5); 7.8672 (2.0); 7.4607 (0.6); 3.7328 (6.1); 3.7191 (1.0); 3.3092 (16.0); 2.5232 (0.6); 2.5186 (0.8); 2.5099 (6.6); 2.5053 (13.4); 2.5007 (18.2); 2.4961 (12.4); 2.4916 (5.4); 1.7826 (0.5); 1.7746 (1.3);

1.7117 (7.1); -0.0002 (3.8) 1.7117 (7.1); -0.0002 (3.8)

1.116-152: 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-152: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.8166 (1.8); 3.7267 (5.4); 3.3093 (16.0); 2.5183 (0.7); 2.5097 (6.3); 2.5052 (12.7); 2.5006 (17.1); 2.4961 (11.9);δ = 7.8166 (1.8); 3.7267 (5.4); 3.3093 (16.0); 2.5183 (0.7); 2.5097 (6.3); 2.5052 (12.7); 2.5006 (17.1); 2.4961 (11.9);

2.4916 (5.4); 1.6983 (6.9); -0.0002 (2.9) 2.4916 (5.4); 1.6983 (6.9); -0.0002 (2.9)

1.116-167: 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-167: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7831 (1.8); 3.7198 (5.1); 3.3093 (16.0); 2.5231 (0.6); 2.5184 (0.7); 2.5097 (5.8); 2.5052 (11.7); 2.5006 (15.8);δ = 7.7831 (1.8); 3.7198 (5.1); 3.3093 (16.0); 2.5231 (0.6); 2.5184 (0.7); 2.5097 (5.8); 2.5052 (11.7); 2.5006 (15.8);

2.4960 (10.9); 2.4915 (4.9); 1.6957 (6.6); -0.0002 (3.1) 2.4960 (10.9); 2.4915 (4.9); 1.6957 (6.6); -0.0002 (3.1)

1.116-2: 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-2: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.6947 (1.2); 3.7200 (1.4); 3.7188 (1.7); 3.7136 (3.6); 3.6462 (1.0); 3.3092 (16.0); 2.5183 (0.7); 2.5096 (6.1); 2.5051 (12.5); 2.5005 (17.1); 2.4959 (11.7); 2.4913 (5.1); 1.7823 (1.3); 1.7742 (1.6); 1.6688 (3.7); 1.2320 (2.2);δ = 7.6947 (1.2); 3.7200 (1.4); 3.7188 (1.7); 3.7136 (3.6); 3.6462 (1.0); 3.3092 (16.0); 2.5183 (0.7); 2.5096 (6.1); 2.5051 (12.5); 2.5005 (17.1); 2.4959 (11.7); 2.4913 (5.1); 1.7823 (1.3); 1.7742 (1.6); 1.6688 (3.7); 1.2320 (2.2);

1.1401 (0.8); -0.0002 (3.6) 1.1401 (0.8); -0.0002 (3.6)

1.116-34: 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-34: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7528 (1.9); 4.6799 (0.7); 4.6640 (0.9); 4.6610 (0.5); 4.6460 (0.5); 4.4619 (0.7); 4.4454 (1.2); 4.4296 (0.6); 3.7262 (5.2); 3.3098 (16.0); 2.5182 (0.6); 2.5095 (5.4); 2.5050 (11.2); 2.5004 (15.2); 2.4958 (10.6); 2.4913 (4.8);δ = 7.7528 (1.9); 4.6799 (0.7); 4.6640 (0.9); 4.6610 (0.5); 4.6460 (0.5); 4.4619 (0.7); 4.4454 (1.2); 4.4296 (0.6); 3.7262 (5.2); 3.3098 (16.0); 2.5182 (0.6); 2.5095 (5.4); 2.5050 (11.2); 2.5004 (15.2); 2.4958 (10.6); 2.4913 (4.8);

1.7248 (5.4); -0.0002 (3.0) 1.7248 (5.4); -0.0002 (3.0)

1.116-211 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.116-211: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.4784 (0.5); 8.4669 (0.6); 7.7441 (0.6); 7.7429 (0.6); 7.7391 (2.9); 7.4604 (0.5); 7.4593 (0.5); 7.4493 (0.7); 3.8442 (1.0); 3.8380 (1.0); 3.8302 (1.0); 3.8239 (1.0); 3.7210 (7.6); 3.3098 (16.0); 3.0622 (0.5); 3.0560 (1.2); 2.5182 (0.6); 2.5095 (5.7); 2.5050 (11.9); 2.5004 (16.2); 2.4958 (11.2); 2.4912 (5.0); 1.7743 (0.5); 1.7260 (7.8); -0.0002 (3.4) 1.116-213: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 8.4784 (0.5); 8.4669 (0.6); 7.7441 (0.6); 7.7429 (0.6); 7.7391 (2.9); 7.4604 (0.5); 7.4593 (0.5); 7.4493 (0.7); 3.8442 (1.0); 3.8380 (1.0); 3.8302 (1.0); 3.8239 (1.0); 3.7210 (7.6); 3.3098 (16.0); 3.0622 (0.5); 3.0560 (1.2); 2.5182 (0.6); 2.5095 (5.7); 2.5050 (11.9); 2.5004 (16.2); 2.4958 (11.2); 2.4912 (5.0); 1.7743 (0.5); 1.7260 (7.8); -0.0002 (3.4) 1.116-213: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 7.7866 (1.6); 4.0894 (1.2); 4.0755 (1.2); 3.7301 (4.8); 3.3091 (16.0); 2.5181 (0.6); 2.5094 (5.9); 2.5049 (12.1);δ = 7.7866 (1.6); 4.0894 (1.2); 4.0755 (1.2); 3.7301 (4.8); 3.3091 (16.0); 2.5181 (0.6); 2.5094 (5.9); 2.5049 (12.1);

2.5003 (16.5); 2.4957 (11.4); 2.4911 (5.0); 1.7409 (5.0); -0.0002 (3.4) 2.5003 (16.5); 2.4957 (11.4); 2.4911 (5.0); 1.7409 (5.0); -0.0002 (3.4)

1.127-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.127-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7444 (3.4); 7.4171 (0.5); 7.3960 (0.9); 7.3801 (0.5); 7.3749 (0.5); 7.2597 (28.9); 7.0387 (1.3); 7.0203 (1.7); 6.9995 (1.1); 6.6133 (0.6); 5.2985 (1.9); 2.7224 (0.5); 2.7136 (0.8); 2.7040 (0.8); 2.6955 (0.5); 2.2414 (9.6); 1.8694 (16.0); 1.5499 (0.9); 0.7204 (1.5); 0.7171 (1.6); 0.7032 (1.7); 0.6993 (1.3); 0.6860 (0.5); 0.4123 (0.6); 0.3993 (1.6);δ = 7.7444 (3.4); 7.4171 (0.5); 7.3960 (0.9); 7.3801 (0.5); 7.3749 (0.5); 7.2597 (28.9); 7.0387 (1.3); 7.0203 (1.7); 6.9995 (1.1); 6.6133 (0.6); 5.2985 (1.9); 2.7224 (0.5); 2.7136 (0.8); 2.7040 (0.8); 2.6955 (0.5); 2.2414 (9.6); 1.8694 (16.0); 1.5499 (0.9); 0.7204 (1.5); 0.7171 (1.6); 0.7032 (1.7); 0.6993 (1.3); 0.6860 (0.5); 0.4123 (0.6); 0.3993 (1.6);

0.3957 (1.7); 0.3898 (1.6); -0.0002 (12.4); -0.0085 (1.3) 0.3957 (1.7); 0.3898 (1.6); -0.0002 (12.4); -0.0085 (1.3)

1.127-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.127-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6687 (4.2); 7.3599 (0.8); 7.2597 (47.6); 6.9933 (1.0); 6.9751 (1.1); 6.9723 (1.0); 6.9542 (0.9); 3.5251 (0.8); 2.6004 (0.8); 2.2114 (10.4); 1.8626 (0.7); 1.8466 (16.0); 1.7377 (1.2); 1.7276 (1.1); 1.7212 (1.1); 0.0080 (0.7); -δ = 7.6687 (4.2); 7.3599 (0.8); 7.2597 (47.6); 6.9933 (1.0); 6.9751 (1.1); 6.9723 (1.0); 6.9542 (0.9); 3.5251 (0.8); 2.6004 (0.8); 2.2114 (10.4); 1.8626 (0.7); 1.8466 (16.0); 1.7377 (1.2); 1.7276 (1.1); 1.7212 (1.1); 0.0080 (0.7); -

0.0002 (23.1); -0.0085 (0.7) 0.0002 (23.1); -0.0085 (0.7)

1.127-124: 1 H-NMR(400.0 MHz, CDCI3):  1.127-124: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6124 (4.5); 7.3604 (0.8); 7.2600 (31.4); 6.9976 (1.0); 6.9794 (1.1); 6.9766 (1.0); 6.9584 (0.9); 2.2076 (10.5);δ = 7.6124 (4.5); 7.3604 (0.8); 7.2600 (31.4); 6.9976 (1.0); 6.9794 (1.1); 6.9766 (1.0); 6.9584 (0.9); 2.2076 (10.5);

1.8623 (0.6); 1.8466 (16.0); 1.5429 (0.6); 1.5345 (0.6); 1.5193 (0.6); -0.0002 (15.3); -0.0085 (0.6) 1.8623 (0.6); 1.8466 (16.0); 1.5429 (0.6); 1.5345 (0.6); 1.5193 (0.6); -0.0002 (15.3); -0.0085 (0.6)

1.127-136: 1 H-NMR(400.0 MHz, CDCI3):  1.127-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6364 (3.4); 7.5181 (0.6); 7.3798 (0.7); 7.2593 (108.0); 7.0105 (1.0); 6.9922 (1.3); 6.9895 (1.1); 6.9711 (0.9);δ = 7.6364 (3.4); 7.5181 (0.6); 7.3798 (0.7); 7.2593 (108.0); 7.0105 (1.0); 6.9922 (1.3); 6.9895 (1.1); 6.9711 (0.9);

5.2983 (2.4); 2.2143 (9.1); 1.8528 (11.4); 1.5295 (16.0); 0.0080 (1.5); -0.0002 (39.9); -0.0085 (2.1) 5.2983 (2.4); 2.2143 (9.1); 1.8528 (11.4); 1.5295 (16.0); 0.0080 (1.5); -0.0002 (39.9); -0.0085 (2.1)

1.127-152: 1 H-NMR(400.0 MHz, CDCI3):  1.127-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6434 (3.7); 7.3746 (0.8); 7.2600 (22.6); 7.0056 (1.1); 6.9876 (1.3); 6.9846 (1.2); 6.9666 (1.0); 2.2137 (10.2);δ = 7.6434 (3.7); 7.3746 (0.8); 7.2600 (22.6); 7.0056 (1.1); 6.9876 (1.3); 6.9846 (1.2); 6.9666 (1.0); 2.2137 (10.2);

1.8721 (0.8); 1.8591 (16.0); 1.5428 (2.3); -0.0002 (10.8) 1.8721 (0.8); 1.8591 (16.0); 1.5428 (2.3); -0.0002 (10.8)

1.127-167: 1 H-NMR(400.0 MHz, CDCI3):  1.127-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6227 (4.1); 7.3610 (0.7); 7.2595 (59.1); 6.9966 (1.0); 6.9784 (1.0); 6.9757 (1.0); 6.9575 (0.9); 2.2134 (9.8);δ = 7.6227 (4.1); 7.3610 (0.7); 7.2595 (59.1); 6.9966 (1.0); 6.9784 (1.0); 6.9757 (1.0); 6.9575 (0.9); 2.2134 (9.8);

1.8695 (0.6); 1.8524 (16.0); 1.5367 (1.0); 0.0080 (0.8); -0.0002 (28.5); -0.0085 (1.0) 1.8695 (0.6); 1.8524 (16.0); 1.5367 (1.0); 0.0080 (0.8); -0.0002 (28.5); -0.0085 (1.0)

1.127-2: 1 H-NMR(400.0 MHz, CDCI3):  1.127-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7330 (3.8); 7.3963 (0.8); 7.2593 (48.0); 7.0399 (1.1); 7.0216 (1.3); 7.0189 (1.2); 7.0007 (1.0); 5.2980 (1.0); 2.2372 (10.5); 1.8437 (16.0); 1.5345 (6.5); 1.3063 (6.8); 0.6076 (1.4); 0.6008 (1.3); 0.5785 (1.3); 0.5757 (1.3); 0.5704δ = 7.7330 (3.8); 7.3963 (0.8); 7.2593 (48.0); 7.0399 (1.1); 7.0216 (1.3); 7.0189 (1.2); 7,0007 (1.0); 5.2980 (1.0); 2.2372 (10.5); 1.8437 (16.0); 1.5345 (6.5); 1.3063 (6.8); 0.6076 (1.4); 0.6008 (1.3); 0.5785 (1.3); 0.5757 (1.3); 0.5704

(1.4) ; 0.5677 (1.5); 0.0079 (0.6); -0.0002 (17.5); -0.0084 (0.7) (1.4); 0.5677 (1.5); 0.0079 (0.6); -0.0002 (17.5); -0.0084 (0.7)

1.127-3: 1 H-NMR(400.0 MHz, CDCI3):  1.127-3: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7369 (3.8); 7.5350 (0.8); 7.4396 (0.5); 7.4185 (0.9); 7.4019 (0.5); 7.3974 (0.6); 7.2599 (29.4); 7.0571 (1.3); 7.0384 (1.7); 7.0176 (1.2); 5.2985 (0.8); 2.2598 (10.6); 1.8781 (16.0); 1.8525 (0.6); 1.5218 (1.0); 1.5068 (2.0); 1.5008 (2.0); 1.4863 (1.0); 1.1403 (1.0); 1.1258 (1.9); 1.1201 (1.8); 1.1048 (0.8); -0.0002 (14.3); -0.0085 (0.8) δ = 7.7369 (3.8); 7.5350 (0.8); 7.4396 (0.5); 7.4185 (0.9); 7.4019 (0.5); 7.3974 (0.6); 7.2599 (29.4); 7.0571 (1.3); 7.0384 (1.7); 7.0176 (1.2); 5.2985 (0.8); 2.2598 (10.6); 1.8781 (16.0); 1.8525 (0.6); 1.5218 (1.0); 1.5068 (2.0); 1.5008 (2.0); 1.4863 (1.0); 1.1403 (1.0); 1.1258 (1.9); 1.1201 (1.8); 1.1048 (0.8); -0.0002 (14.3); -0.0085 (0.8)

1.127- 284: 1 H-NMR(400.0 MHz, CDCI3):  1.127-284: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6332 (6.5); 7.3909 (0.6); 7.3699 (1.2); 7.3488 (0.7); 7.2676 (0.5); 7.2668 (0.6); 7.2660 (0.7); 7.2652 (0.8); 7.2643 (1.0); 7.2595 (67.1); 7.2530 (1.5); 7.2522 (1.4); 7.2506 (1.1); 7.2490 (0.8); 7.2466 (0.6); 7.2450 (0.6); 7.0030δ = 7.6332 (6.5); 7.3909 (0.6); 7.3699 (1.2); 7.3488 (0.7); 7.2676 (0.5); 7.2668 (0.6); 7.2660 (0.7); 7.2652 (0.8); 7.2643 (1.0); 7.2595 (67.1); 7.2530 (1.5); 7.2522 (1.4); 7.2506 (1.1); 7.2490 (0.8); 7.2466 (0.6); 7.2450 (0.6); 7.0030

(1.5) ; 6.9955 (0.6); 6.9846 (1.7); 6.9819 (1.6); 6.9637 (1.4); 5.2980 (1.7); 2.2059 (15.2); 1.8577 (16.0); 1.5349 (10.0); 0.0080 (0.7); -0.0002 (24.6); -0.0067 (0.8); -0.0085 (1.1) (1.5); 6.9955 (0.6); 6.9846 (1.7); 6.9819 (1.6); 6.9637 (1.4); 5.2980 (1.7); 2.2059 (15.2); 1.8577 (16.0); 1.5349 (10.0); 0.0080 (0.7); -0.0002 (24.6); -0.0067 (0.8); -0.0085 (1.1)

1.128- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.128-1: 1 H-NMR (400.0 MHz, CDCl3):

δ= 7.6782 (3.8); 7.6271 (0.7); 7.6225 (0.8); 7.2601 (18.6); 7.2404 (0.9); 7.2375 (1.0); 7.1874 (0.6); 2.7101 (0.6); 2.7006 (0.6); 2.2283 (11.8); 1.8546 (16.0); 1.5731 (0.6); 0.7320 (0.9); 0.7285 (1.2); 0.7144 (1.1); 0.7106 (0.9); 0.4287 (0.8); 0.4257 (0.9); 0.4222 (0.9); 0.4160 (0.9); 0.4125 (0.8); -0.0002 (7.5) 1.128-101 : 1 H-NMR(400.0 MHz, CDCI3): δ = 7.6782 (3.8); 7.6271 (0.7); 7.6225 (0.8); 7.2601 (18.6); 7.2404 (0.9); 7.2375 (1.0); 7.1874 (0.6); 2.7101 (0.6); 2,7006 (0.6); 2.2283 (11.8); 1.8546 (16.0); 1.5731 (0.6); 0.7320 (0.9); 0.7285 (1.2); 0.7144 (1.1); 0.7106 (0.9); 0.4287 (0.8); 0.4257 (0.9); 0.4222 (0.9); 0.4160 (0.9); 0.4125 (0.8); -0.0002 (7.5) 1.128-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5914 (3.6); 7.5320 (0.7); 7.5275 (0.8); 7.2614 (9.8); 7.2224 (0.5); 7.2197 (0.6); 7.2037 (0.9); 7.2008 (1.0); 7.1695 (0.5); 7.1450 (0.7); 3.5325 (0.8); 2.6265 (0.8); 2.2141 (10.6); 1.8413 (16.0); 1.7470 (0.8); 1.7369 (1.1); 1.7301δ = 7.5914 (3.6); 7.5320 (0.7); 7.5275 (0.8); 7.2614 (9.8); 7.2224 (0.5); 7.2197 (0.6); 7.2037 (0.9); 7.2008 (1.0); 7.1695 (0.5); 7.1450 (0.7); 3.5325 (0.8); 2.6265 (0.8); 2.2141 (10.6); 1.8413 (16.0); 1.7470 (0.8); 1.7369 (1.1); 1.7301

(2.2) ; 1.7232 (1.2); 1.7132 (0.6); -0.0002 (3.8) (2.2); 1.7232 (1.2); 1.7132 (0.6); -0.0002 (3.8)

1.128-124: 1 H-NMR(400.0 MHz, CDCI3):  1.128-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5448 (0.8); 7.5409 (4.5); 7.2601 (18.9); 7.2246 (0.5); 7.2217 (0.6); 7.2058 (0.9); 7.2029 (1.0); 7.1498 (0.6);δ = 7.5448 (0.8); 7.5409 (4.5); 7.2601 (18.9); 7.2246 (0.5); 7.2217 (0.6); 7.2058 (0.9); 7.2029 (1.0); 7.1498 (0.6);

5.2981 (0.6); 2.2114 (10.8); 1.8410 (16.0); 1.5207 (0.6); -0.0002 (7.6) 5.2981 (0.6); 2.2114 (10.8); 1.8410 (16.0); 1.5207 (0.6); -0.0002 (7.6)

1.128-152: 1 H-NMR(400.0 MHz, CDCI3):  1.128-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.5712 (3.7); 7.5373 (0.7); 7.5327 (0.8); 7.2606 (11.6); 7.2317 (0.5); 7.2288 (0.6); 7.2129 (0.9); 7.2100 (1.0);δ = 7.5712 (3.7); 7.5373 (0.7); 7.5327 (0.8); 7.2606 (11.6); 7.2317 (0.5); 7.2288 (0.6); 7.2129 (0.9); 7.2100 (1.0);

7.1545 (0.6); 5.2981 (0.7); 2.2148 (10.7); 1.8509 (16.0); 1.5600 (1.1); -0.0002 (5.0) 7.1545 (0.6); 5.2981 (0.7); 2.2148 (10.7); 1.8509 (16.0); 1.5600 (1.1); -0.0002 (5.0)

1.128-167: 1 H-NMR(400.0 MHz, CDCI3):  1.128-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.5456 (3.9); 7.2611 (9.6); 7.2237 (0.5); 7.2207 (0.6); 7.2049 (0.8); 7.2019 (0.9); 7.1489 (0.6); 2.2175 (10.2); 1.8477 (16.0); -0.0002 (3.8) δ = 7.5456 (3.9); 7.2611 (9.6); 7.2237 (0.5); 7.2207 (0.6); 7.2049 (0.8); 7.2019 (0.9); 7.1489 (0.6); 2.2175 (10.2); 1.8477 (16.0); -0.0002 (3.8)

1.128- 353: 1 H-NMR(400.0 MHz, CDCI3):  1.128-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.7342 (0.7); 7.6902 (0.5); 7.6866 (4.7); 7.6718 (0.8); 7.6672 (0.8); 7.2722 (0.7); 7.2692 (0.8); 7.2607 (17.2); 7.2534 (1.0); 7.2504 (1.1); 7.2315 (0.5); 7.1961 (0.5); 3.9337 (1.3); 3.9255 (0.9); 3.9228 (1.4); 3.9193 (0.8); 3.9157 (0.5); 3.9116 (1.5); 3.6626 (0.7); 3.6516 (0.8); 3.6411 (0.6); 2.2411 (13.4); 1.9033 (16.0); -0.0002 (8.6) δ = 9.7342 (0.7); 7.6902 (0.5); 7.6866 (4.7); 7.6718 (0.8); 7.6672 (0.8); 7.2722 (0.7); 7.2692 (0.8); 7.2607 (17.2); 7.2534 (1.0); 7.2504 (1.1); 7.2315 (0.5); 7.1961 (0.5); 3.9337 (1.3); 3.9255 (0.9); 3.9228 (1.4); 3.9193 (0.8); 3.9157 (0.5); 3.9116 (1.5); 3.6626 (0.7); 3.6516 (0.8); 3.6411 (0.6); 2.2411 (13.4); 1.9033 (16.0); -0.0002 (8.6)

1.129- 1 : 1 H-NMR(400.0 MHz, CDCI3):  1.129-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7563 (3.5); 7.3839 (0.8); 7.3696 (0.8); 7.3636 (0.7); 7.3496 (0.8); 7.3362 (1.4); 7.3346 (1.4); 7.3179 (0.6); 7.3160 (0.6); 7.2597 (32.3); 7.1439 (0.6); 7.1409 (0.6); 7.1232 (1.0); 7.1202 (0.9); 7.1025 (0.6); 7.0989 (0.5); 6.4885 (0.5); 2.6796 (0.7); 2.6704 (0.7); 2.6614 (0.6); 2.2015 (10.1); 1.8892 (0.7); 1.8749 (16.0); 1.5406 (3.6); 0.7092 (1.3); 0.7061 (1.6); 0.6919 (1.6); 0.6883 (1.4); 0.6754 (0.6); 0.3797 (1.4); 0.3764 (1.5); 0.3701 (1.5); 0.3668 (1.4); 0.3533δ = 7.7563 (3.5); 7.3839 (0.8); 7.3696 (0.8); 7.3636 (0.7); 7.3496 (0.8); 7.3362 (1.4); 7.3346 (1.4); 7.3179 (0.6); 7.3160 (0.6); 7.2597 (32.3); 7.1439 (0.6); 7.1409 (0.6); 7.1232 (1.0); 7.1202 (0.9); 7.1025 (0.6); 7.0989 (0.5); 6.4885 (0.5); 2.6796 (0.7); 2.6704 (0.7); 2.6614 (0.6); 2.2015 (10.1); 1.8892 (0.7); 1.8749 (16.0); 1.5406 (3.6); 0.7092 (1.3); 0.7061 (1.6); 0.6919 (1.6); 0.6883 (1.4); 0.6754 (0.6); 0.3797 (1.4); 0.3764 (1.5); 0.3701 (1.5); 0.3668 (1.4); 0.3533

(0.5); -0.0002 (14.6) (0.5); -0.0002 (14.6)

1.129-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.129-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6711 (3.2); 7.3435 (0.8); 7.3293 (0.8); 7.3233 (0.7); 7.3095 (0.8); 7.2979 (1.5); 7.2814 (0.7); 7.2598 (31.8); 7.0984 (0.6); 7.0776 (1.0); 7.0574 (0.5); 3.5261 (1.5); 2.6658 (1.2); 2.1842 (9.4); 1.8646 (0.6); 1.8484 (16.0); 1.7330δ = 7.6711 (3.2); 7.3435 (0.8); 7.3293 (0.8); 7.3233 (0.7); 7.3095 (0.8); 7.2979 (1.5); 7.2814 (0.7); 7.2598 (31.8); 7.0984 (0.6); 7.0776 (1.0); 7.0574 (0.5); 3.5261 (1.5); 2.6658 (1.2); 2.1842 (9.4); 1.8646 (0.6); 1.8484 (16.0); 1.7330

(2.3) ; 1.7253 (2.5); 1.7179 (2.4); 1.5424 (3.8); -0.0002 (13.8) (2.3); 1.7253 (2.5); 1.7179 (2.4); 1.5424 (3.8); -0.0002 (13.8)

1.129-152: 1 H-NMR(400.0 MHz, CDCI3):  1.129-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6369 (3.6); 7.3571 (0.8); 7.3429 (0.8); 7.3369 (0.8); 7.3229 (0.8); 7.3095 (1.7); 7.2910 (0.8); 7.2597 (35.8); 7.1105 (0.6); 7.1074 (0.6); 7.0898 (1.0); 7.0695 (0.6); 7.0656 (0.5); 3.5051 (0.7); 2.1899 (10.5); 1.8766 (0.5); 1.8571δ = 7.6369 (3.6); 7.3571 (0.8); 7.3429 (0.8); 7.3369 (0.8); 7.3229 (0.8); 7.3095 (1.7); 7.2910 (0.8); 7.2597 (35.8); 7.1105 (0.6); 7.1074 (0.6); 7.0898 (1.0); 7.0695 (0.6); 7.0656 (0.5); 3.5051 (0.7); 2.1899 (10.5); 1.8766 (0.5); 1.8571

(16.0); 1.5385 (4.8); -0.0002 (15.5) (16.0); 1.5385 (4.8); -0.0002 (15.5)

1.129-167: 1 H-NMR(400.0 MHz, CDCI3):  1.129-167: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6238 (3.5); 7.3444 (0.8); 7.3302 (0.7); 7.3241 (0.7); 7.3107 (0.8); 7.3023 (1.0); 7.2997 (1.4); 7.2820 (0.5); 7.2597 (33.7); 7.1016 (0.5); 7.0984 (0.5); 7.0808 (0.8); 7.0779 (0.7); 2.1866 (10.0); 1.8704 (0.5); 1.8533 (16.0);δ = 7.6238 (3.5); 7.3444 (0.8); 7.3302 (0.7); 7.3241 (0.7); 7.3107 (0.8); 7.3023 (1.0); 7.2997 (1.4); 7.2820 (0.5); 7.2597 (33.7); 7.1016 (0.5); 7.0984 (0.5); 7.0808 (0.8); 7.0779 (0.7); 2.1866 (10.0); 1.8704 (0.5); 1.8533 (16.0);

1.5398 (3.0); -0.0002 (14.5); -0.0082 (1.3) 1.5398 (3.0); -0.0002 (14.5); -0.0082 (1.3)

1.129-213: 1 H-NMR(400.0 MHz, CDCI3):  1.129-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7791 (3.4); 7.4417 (0.5); 7.4256 (0.6); 7.4108 (0.5); 7.4051 (0.9); 7.3907 (0.9); 7.3847 (0.8); 7.3707 (0.8); 7.3567 (1.5); 7.3366 (0.7); 7.2596 (28.9); 7.1655 (0.6); 7.1626 (0.6); 7.1442 (1.0); 7.1240 (0.6); 7.1204 (0.5); 4.0973δ = 7.7791 (3.4); 7.4417 (0.5); 7.4256 (0.6); 7.4108 (0.5); 7.4051 (0.9); 7.3907 (0.9); 7.3847 (0.8); 7.3707 (0.8); 7.3567 (1.5); 7.3366 (0.7); 7.2596 (28.9); 7.1655 (0.6); 7.1626 (0.6); 7.1442 (1.0); 7.1240 (0.6); 7.1204 (0.5); 4.0973

(2.8); 4.0830 (3.0); 2.2196 (10.0); 1.9058 (16.0); 1.5367 (3.8); -0.0002 (12.8) (2.8); 4.0830 (3.0); 2.2196 (10.0); 1.9058 (16.0); 1.5367 (3.8); -0.0002 (12.8)

1.131 -136: 1 H-NMR(400.0 MHz, CDCI3):  1.131-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.6322 (1.3); 8.6286 (1.3); 8.6206 (1.4); 8.6169 (1.4); 7.8300 (1.4); 7.8263 (1.3); 7.8097 (1.5); 7.8060 (1.4); 7.5182 (1.0); 7.5067 (5.4); 7.3004 (1.6); 7.2888 (1.8); 7.2801 (1.9); 7.2684 (2.8); 7.2594 (181.7); 6.9954 (1.0); 5.2983δ = 8.6322 (1.3); 8.6286 (1.3); 8.6206 (1.4); 8.6169 (1.4); 7.8300 (1.4); 7.8263 (1.3); 7.8097 (1.5); 7.8060 (1.4); 7.5182 (1.0); 7.5067 (5.4); 7.3004 (1.6); 7.2888 (1.8); 7.2801 (1.9); 7.2684 (2.8); 7.2594 (181.7); 6.9954 (1.0); 5.2983

(5.4) ; 2.7692 (0.6); 2.2764 (16.0); 2.0434 (1.8); 1.8901 (0.6); 1.8574 (16.0); 1.5320 (9.9); 1.2764 (0.6); 1.2585 (1.2);(5.4); 2.7692 (0.6); 2.2764 (16.0); 2.0434 (1.8); 1.8901 (0.6); 1.8574 (16.0); 1.5320 (9.9); 1.2764 (0.6); 1.2585 (1.2);

0.0080 (2.0); -0.0002 (66.2); -0.0085 (2.7) 0.0080 (2.0); -0.0002 (66.2); -0.0085 (2.7)

1.131 -2: 1 H-NMR(400.0 MHz, CDCI3):  1.131 -2: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.6495 (1.0); 8.6458 (1.0); 8.6378 (1.0); 8.6341 (1.0); 7.8519 (1.0); 7.8482 (1.1); 7.8315 (1.2); 7.8278 (1.1); 7.6192 (4.0); 7.3133 (1.2); 7.3016 (1.2); 7.2929 (1.3); 7.2812 (1.2); 7.2594 (76.6); 5.2981 (0.9); 2.3160 (12.5); 2.1936 (0.5); 1.8706 (1.6); 1.8430 (16.0); 1.5376 (1.2); 1.2955 (6.6); 0.6153 (1.3); 0.6056 (1.4); 0.5779 (1.6); 0.5672 (1.4);δ = 8.6495 (1.0); 8.6458 (1.0); 8.6378 (1.0); 8.6341 (1.0); 7.8519 (1.0); 7.8482 (1.1); 7.8315 (1.2); 7.8278 (1.1); 7.6192 (4.0); 7.3133 (1.2); 7.3016 (1.2); 7.2929 (1.3); 7.2812 (1.2); 7.2594 (76.6); 5.2981 (0.9); 2.3160 (12.5); 2.1936 (0.5); 1.8706 (1.6); 1.8430 (16.0); 1.5376 (1.2); 1.2955 (6.6); 0.6153 (1.3); 0.6056 (1.4); 0.5779 (1.6); 0.5672 (1.4);

0.0080 (0.9); -0.0002 (28.4); -0.0084 (1.1) 0.0080 (0.9); -0.0002 (28.4); -0.0084 (1.1)

1.144-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.144-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6675 (0.6); 7.6628 (0.7); 7.3039 (3.8); 7.2646 (0.6); 7.2597 (46.5); 7.2209 (0.6); 7.2178 (0.7); 7.2020 (0.8); 7.1988 (1.0); 7.1832 (0.9); 7.1801 (0.8); 3.7924 (12.6); 2.6930 (0.6); 2.6835 (0.6); 1.8399 (16.0); 1.5425 (15.4); 0.7193 (0.8); 0.7158 (1.2); 0.7130 (0.6); 0.7017 (1.0); 0.6979 (0.9); 0.4159 (0.7); 0.4129 (0.8); 0.4094 (0.8); 0.4069δ = 7.6675 (0.6); 7.6628 (0.7); 7.3039 (3.8); 7.2646 (0.6); 7.2597 (46.5); 7.2209 (0.6); 7.2178 (0.7); 7.2020 (0.8); 7.1988 (1.0); 7.1832 (0.9); 7.1801 (0.8); 3.7924 (12.6); 2.6930 (0.6); 2.6835 (0.6); 1.8399 (16.0); 1.5425 (15.4); 0.7193 (0.8); 0.7158 (1.2); 0.7130 (0.6); 0.7017 (1.0); 0.6979 (0.9); 0.4159 (0.7); 0.4129 (0.8); 0.4094 (0.8); 0.4069

(0.7); 0.4032 (0.8); 0.3997 (0.8); 0.0079 (0.6); -0.0002 (20.3); -0.0085 (0.6) (0.7); 0.4032 (0.8); 0.3997 (0.8); 0.0079 (0.6); -0.0002 (20.3); -0.0085 (0.6)

1.144-2: 1 H-NMR(400.0 MHz, CDCI3):  1.144-2: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6664 (0.6); 7.6617 (0.7); 7.2884 (3.8); 7.2596 (43.1); 7.2227 (0.6); 7.2196 (0.7); 7.2039 (0.8); 7.2007 (1.1); 7.1866 (0.5); 7.1849 (0.7); 7.1820 (0.5); 3.7913 (12.6); 1.8151 (16.0); 1.5426 (14.0); 1.3078 (5.9); 0.6158 (1.0);δ = 7.6664 (0.6); 7.6617 (0.7); 7.2884 (3.8); 7.2596 (43.1); 7.2227 (0.6); 7.2196 (0.7); 7.2039 (0.8); 7.2007 (1.1); 7.1866 (0.5); 7.1849 (0.7); 7.1820 (0.5); 3.7913 (12.6); 1.8151 (16.0); 1.5426 (14.0); 1.3078 (5.9); 0.6158 (1.0);

0.6066 (1.1); 0.5793 (1.4); 0.5733 (1.0); 0.5712 (1.1); 0.5690 (1.1); 0.0079 (0.6); -0.0002 (19.5); -0.0085 (0.6) 0.6066 (1.1); 0.5793 (1.4); 0.5733 (1.0); 0.5712 (1.1); 0.5690 (1.1); 0.0079 (0.6); -0.0002 (19.5); -0.0085 (0.6)

1.144-34: 1 H-NMR(400.0 MHz, CDCI3):  1.144-34: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.7284 (0.5); 7.7141 (0.9); 7.7094 (0.9); 7.3304 (3.8); 7.2597 (44.8); 7.2404 (0.6); 7.2372 (0.8); 7.2215 (0.9); 7.2183 (1.2); 7.2095 (0.9); 7.2027 (0.5); 7.1995 (0.5); 4.9371 (0.6); 4.8662 (1.2); 4.8492 (1.6); 4.8313 (0.8); 4.4650 (1.1); 4.4477 (1.8); 4.4321 (1.0); 3.8120 (13.3); 1.8521 (16.0); 1.5422 (16.8); 0.0079 (0.6); -0.0002 (19.3); -0.0085 (0-6) 1.144-101 : 1 H-NMR(400.0 MHz, CDCI3): δ = 7.7284 (0.5); 7.7141 (0.9); 7.7094 (0.9); 7.3304 (3.8); 7.2597 (44.8); 7.2404 (0.6); 7.2372 (0.8); 7.2215 (0.9); 7.2183 (1.2); 7.2095 (0.9); 7.2027 (0.5); 7.1995 (0.5); 4.9371 (0.6); 4.8662 (1.2); 4.8492 (1.6); 4.8313 (0.8); 4.4650 (1.1); 4.4477 (1.8); 4.4321 (1.0); 3.8120 (13.3); 1.8521 (16.0); 1.5422 (16.8); 0.0079 (0.6); -0.0002 (19.3); -0.0085 (0-6) 1.144-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6223 (0.6); 7.6177 (0.7); 7.2597 (42.4); 7.1967 (4.0); 7.1929 (0.7); 7.1897 (0.7); 7.1740 (0.8); 7.1708 (0.9); 3.7694 (11.8); 3.5382 (0.7); 2.7011 (0.8); 1.8210 (16.0); 1.7453 (1.1); 1.7357 (0.9); 1.7281 (2.8); 1.7206 (0.9); 1.7109δ = 7.6223 (0.6); 7.6177 (0.7); 7.2597 (42.4); 7.1967 (4.0); 7.1929 (0.7); 7.1897 (0.7); 7.1740 (0.8); 7.1708 (0.9); 3.7694 (11.8); 3.5382 (0.7); 2.7011 (0.8); 1.8210 (16.0); 1.7453 (1.1); 1.7357 (0.9); 1.7281 (2.8); 1.7206 (0.9); 1.7109

(0.8); 1.5467 (11.2); 0.0080 (0.6); -0.0002 (18.0); -0.0085 (0.5) (0.8); 1.5467 (11.2); 0.0080 (0.6); -0.0002 (18.0); -0.0085 (0.5)

1.144-124: 1 H-NMR(400.0 MHz, CDCI3):  1.144-124: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6294 (0.6); 7.6248 (0.6); 7.2597 (48.7); 7.1938 (0.6); 7.1907 (0.7); 7.1750 (0.8); 7.1718 (1.0); 7.1613 (4.0); 7.1561 (0.5); 7.1530 (0.5); 3.7639 (11.8); 1.8208 (16.0); 1.5413 (16.8); 1.5228 (0.6); 0.0079 (0.6); -0.0002 (21.0); -δ = 7.6294 (0.6); 7.6248 (0.6); 7.2597 (48.7); 7.1938 (0.6); 7.1907 (0.7); 7.1750 (0.8); 7.1718 (1.0); 7.1613 (4.0); 7.1561 (0.5); 7.1530 (0.5); 3.7639 (11.8); 1.8208 (16.0); 1.5413 (16.8); 1.5228 (0.6); 0.0079 (0.6); -0.0002 (21.0); -

0.0085 (0.6) 0.0085 (0.6)

1.144-136: 1 H-NMR(400.0 MHz, CDCI3):  1.144-136: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6220 (0.8); 7.6174 (0.9); 7.2598 (57.8); 7.2032 (0.8); 7.2001 (0.9); 7.1844 (1.1); 7.1812 (1.4); 7.1753 (5.3); 7.1655 (0.6); 7.1624 (0.6); 7.1526 (0.6); 7.1500 (0.5); 7.1267 (0.6); 7.1240 (0.5); 5.2984 (0.8); 3.7765 (16.0); 2.7688δ = 7.6220 (0.8); 7.6174 (0.9); 7.2598 (57.8); 7.2032 (0.8); 7.2001 (0.9); 7.1844 (1.1); 7.1812 (1.4); 7.1753 (5.3); 7.1655 (0.6); 7.1624 (0.6); 7.1526 (0.6); 7.1500 (0.5); 7.1267 (0.6); 7.1240 (0.5); 5.2984 (0.8); 3.7765 (16.0); 2.7688

(0.5); 1.8218 (15.4); 1.5411 (19.8); 0.0080 (0.7); -0.0002 (24.8); -0.0084 (0.8) (0.5); 1.8218 (15.4); 1.5411 (19.8); 0.0080 (0.7); -0.0002 (24.8); -0.0084 (0.8)

1.144-137: 1 H-NMR(400.0 MHz, CDCI3):  1.144-137: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6171 (0.6); 7.6125 (0.7); 7.2646 (0.5); 7.2596 (48.8); 7.2013 (0.6); 7.1982 (0.7); 7.1837 (4.3); 7.1793 (1.1); 7.1606 (0.6); 3.7714 (12.2); 3.7666 (0.8); 3.7639 (0.7); 1.8340 (16.0); 1.8208 (1.0); 1.5396 (13.9); 0.0079 (0.6); -δ = 7.6171 (0.6); 7.6125 (0.7); 7.2646 (0.5); 7.2596 (48.8); 7.2013 (0.6); 7.1982 (0.7); 7.1837 (4.3); 7.1793 (1.1); 7.1606 (0.6); 3.7714 (12.2); 3.7666 (0.8); 3.7639 (0.7); 1.8340 (16.0); 1.8208 (1.0); 1.5396 (13.9); 0.0079 (0.6); -

0.0002 (22.3); -0.0028 (1.1); -0.0085 (0.7) 0.0002 (22.3); -0.0028 (1.1); -0.0085 (0.7)

1.144-152: 1 H-NMR(400.0 MHz, CDCI3):  1.144-152: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.6206 (0.6); 7.6159 (0.7); 7.2598 (42.0); 7.1988 (0.6); 7.1957 (0.7); 7.1847 (4.2); 7.1799 (0.9); 7.1768 (1.0);δ = 7.6206 (0.6); 7.6159 (0.7); 7.2598 (42.0); 7.1988 (0.6); 7.1957 (0.7); 7.1847 (4.2); 7.1799 (0.9); 7.1768 (1.0);

3.7776 (12.0); 1.8288 (16.0); 1.5427 (12.8); 0.0080 (0.5); -0.0002 (17.9) 3.7776 (12.0); 1.8288 (16.0); 1.5427 (12.8); 0.0080 (0.5); -0.0002 (17.9)

1.144-167: 1 H-NMR(400.0 MHz, CDCI3):  1.144-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.6309 (0.6); 7.6262 (0.6); 7.2598 (35.4); 7.1926 (0.5); 7.1895 (0.6); 7.1738 (0.8); 7.1706 (0.9); 7.1582 (3.7);δ = 7.6309 (0.6); 7.6262 (0.6); 7.2598 (35.4); 7.1926 (0.5); 7.1895 (0.6); 7.1738 (0.8); 7.1706 (0.9); 7.1582 (3.7);

7.1550 (0.5); 3.7710 (11.3); 1.8285 (16.0); 1.5443 (8.4); -0.0002 (15.3) 7.1550 (0.5); 3.7710 (11.3); 1.8285 (16.0); 1.5443 (8.4); -0.0002 (15.3)

1.144-213: 1 H-NMR(400.0 MHz, CDCI3):  1.144-213: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.7134 (0.7); 7.7087 (0.7); 7.3215 (3.9); 7.2595 (42.8); 7.2378 (0.6); 7.2346 (0.7); 7.2189 (0.9); 7.2157 (1.0); 7.1998 (0.6); 7.1979 (0.6); 7.1969 (0.7); 4.1038 (3.6); 4.0893 (3.6); 3.8112 (13.0); 1.8749 (16.0); 1.5383 (13.5);δ = 7.7134 (0.7); 7.7087 (0.7); 7.3215 (3.9); 7.2595 (42.8); 7.2378 (0.6); 7.2346 (0.7); 7.2189 (0.9); 7.2157 (1.0); 7.1998 (0.6); 7.1979 (0.6); 7.1969 (0.7); 4.1038 (3.6); 4.0893 (3.6); 3.8112 (13.0); 1.8749 (16.0); 1.5383 (13.5);

0.0080 (0.6); -0.0002 (19.5); -0.0085 (0.5) 0.0080 (0.6); -0.0002 (19.5); -0.0085 (0.5)

1.144-353: 1 H-NMR(400.0 MHz, CDCI3):  1.144-353: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 9.6432 (0.8); 7.7072 (0.7); 7.7027 (0.8); 7.3133 (3.6); 7.2596 (21.7); 7.2326 (0.6); 7.2296 (0.7); 7.2137 (0.8); 7.2106 (1.0); 7.1915 (0.9); 7.1644 (0.5); 4.0417 (0.9); 3.9192 (1.2); 3.9083 (1.4); 3.9050 (0.8); 3.9012 (0.5); 3.8971 (1.5); 3.8084 (11.4); 3.6645 (0.7); 3.6533 (0.8); 3.6478 (0.9); 3.6425 (0.8); 3.6366 (0.6); 3.6257 (0.6); 1.8894 (16.0);δ = 9.6432 (0.8); 7.7072 (0.7); 7.7027 (0.8); 7.3133 (3.6); 7.2596 (21.7); 7.2326 (0.6); 7.2296 (0.7); 7.2137 (0.8); 7.2106 (1.0); 7.1915 (0.9); 7.1644 (0.5); 4.0417 (0.9); 3.9192 (1.2); 3.9083 (1.4); 3.9050 (0.8); 3.9012 (0.5); 3.8971 (1.5); 3.8084 (11.4); 3.6645 (0.7); 3.6533 (0.8); 3.6478 (0.9); 3.6425 (0.8); 3.6366 (0.6); 3.6257 (0.6); 1.8894 (16.0);

1.5549 (4.3); -0.0002 (9.5) 1.5549 (4.3); -0.0002 (9.5)

1.155-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.155-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.2254 (3.6); 7.5179 (0.7); 7.4552 (1.0); 7.4341 (0.6); 7.2590 (123.8); 7.2080 (1.4); 7.0616 (1.4); 7.0426 (1.9); 7.0218 (1.3); 6.9949 (0.7); 6.4540 (0.6); 5.2981 (0.7); 3.1165 (10.0); 2.7294 (0.5); 2.7202 (0.7); 2.7109 (0.8); 2.7022 (0.5); 1.8990 (16.0); 1.5279 (13.9); 0.7495 (1.6); 0.7354 (1.7); 0.7187 (0.6); 0.4178 (1.5); -0.0002 (45.9); -0.0513 (0-6) δ = 8.2254 (3.6); 7.5179 (0.7); 7.4552 (1.0); 7.4341 (0.6); 7.2590 (123.8); 7.2080 (1.4); 7.0616 (1.4); 7.0426 (1.9); 7.0218 (1.3); 6.9949 (0.7); 6.4540 (0.6); 5.2981 (0.7); 3.1165 (10.0); 2.7294 (0.5); 2.7202 (0.7); 2.7109 (0.8); 2.7022 (0.5); 1.8990 (16.0); 1.5279 (13.9); 0.7495 (1.6); 0.7354 (1.7); 0.7187 (0.6); 0.4178 (1.5); -0.0002 (45.9); -0.0513 (0-6)

1.155- 167: 1 H-NMR(400.0 MHz, d6-DMSO):  1.155-167: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7807 (4.6); 7.5934 (0.9); 7.5722 (0.6); 7.2429 (1.4); 7.2237 (1.6); 7.2030 (1.2); 5.7526 (4.6); 3.3082 (16.2); 3.1291 (11.8); 2.6739 (0.5); 2.6692 (0.6); 2.5227 (2.0); 2.5180 (2.7); 2.5093 (26.4); 2.5047 (54.3); 2.5002 (74.3); 2.4956 (50.6); 2.4910 (22.6); 1.7693 (16.0); 1.7139 (0.6); 1.2359 (0.9); -0.0002 (1.9) δ = 8.7807 (4.6); 7.5934 (0.9); 7.5722 (0.6); 7.2429 (1.4); 7.2237 (1.6); 7.2030 (1.2); 5.7526 (4.6); 3.3082 (16.2); 3.1291 (11.8); 2.6739 (0.5); 2.6692 (0.6); 2.5227 (2.0); 2.5180 (2.7); 2.5093 (26.4); 2.5047 (54.3); 2.5002 (74.3); 2.4956 (50.6); 2.4910 (22.6); 1.7693 (16.0); 1.7139 (0.6); 1.2359 (0.9); -0.0002 (1.9)

1.156- 1 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.156-1: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.5278 (5.7); 7.7485 (0.8); 7.7397 (0.8); 7.5232 (0.7); 7.5185 (0.5); 7.5160 (0.5); 7.5085 (0.6); 7.5050 (0.6); 7.5024 (0.8); 7.4976 (0.5); 7.4728 (0.6); 7.4684 (0.6); 7.4543 (1.1); 7.4497 (1.2); 7.4346 (0.8); 7.4305 (0.7); 7.3248 (0.7); 7.3226 (0.8); 7.3003 (1.9); 7.2962 (0.8); 7.2836 (1.6); 7.2810 (1.6); 7.2786 (0.9); 7.2755 (0.6); 7.2650 (0.9); 7.2622 (0.7); 3.3100 (25.6); 3.1751 (3.2); 3.1620 (3.1); 3.1281 (15.2); 2.6307 (0.6); 2.6221 (0.9); 2.6125 (1.0); 2.6039 (0.6); 2.5945 (0.5); 2.5227 (0.9); 2.5180 (1.2); 2.5093 (13.8); 2.5048 (29.0); 2.5002 (39.9); 2.4956 (27.4); 2.4910 (12.3); 1.7451 (16.0); 0.6368 (0.6); 0.6247 (1.5); 0.6190 (2.0); 0.6069 (2.0); 0.6010 (1.5); 0.5894 (0.7); 0.4497 (0.8);δ = 8.5278 (5.7); 7.7485 (0.8); 7.7397 (0.8); 7.5232 (0.7); 7.5185 (0.5); 7.5160 (0.5); 7.5085 (0.6); 7.5050 (0.6); 7.5024 (0.8); 7.4976 (0.5); 7.4728 (0.6); 7.4684 (0.6); 7.4543 (1.1); 7.4497 (1.2); 7.4346 (0.8); 7.4305 (0.7); 7.3248 (0.7); 7.3226 (0.8); 7.3003 (1.9); 7.2962 (0.8); 7.2836 (1.6); 7.2810 (1.6); 7.2786 (0.9); 7.2755 (0.6); 7.2650 (0.9); 7.2622 (0.7); 3.3100 (25.6); 3.1751 (3.2); 3.1620 (3.1); 3.1281 (15.2); 2.6307 (0.6); 2.6221 (0.9); 2.6125 (1.0); 2.6039 (0.6); 2.5945 (0.5); 2.5227 (0.9); 2.5180 (1.2); 2.5093 (13.8); 2.5048 (29.0); 2.5002 (39.9); 2.4956 (27.4); 2.4910 (12.3); 1.7451 (16.0); 0.6368 (0.6); 0.6247 (1.5); 0.6190 (2.0); 0.6069 (2.0); 0.6010 (1.5); 0.5894 (0.7); 0.4497 (0.8);

0.4394 (1.8); 0.4328 (1.7); 0.4286 (1.5); 0.4230 (1.6); 0.4111 (0.5) 0.4394 (1.8); 0.4328 (1.7); 0.4286 (1.5); 0.4230 (1.6); 0.4111 (0.5)

1.156-101 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.156-101: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.6794 (5.2); 7.5357 (0.6); 7.5209 (0.5); 7.5149 (0.7); 7.4636 (0.9); 7.4590 (1.0); 7.4438 (0.6); 7.4398 (0.5); 7.3305 (0.6); 7.3283 (0.7); 7.3051 (1.8); 7.2886 (1.4); 7.2860 (1.5); 7.2815 (0.6); 7.2700 (0.7); 7.2672 (0.6); 3.3630 (0.5); 3.3457 (0.8); 3.3289 (0.6); 3.3107 (22.3); 3.1750 (1.0); 3.1625 (1.0); 3.1356 (12.8); 2.5462 (0.9); 2.5230 (1.1); 2.5183 (1.4); 2.5096 (12.6); 2.5051 (25.9); 2.5005 (35.4); 2.4959 (24.2); 2.4913 (10.9); 1.7601 (16.0); 1.7132 (0.7);δ = 8.6794 (5.2); 7.5357 (0.6); 7.5209 (0.5); 7.5149 (0.7); 7.4636 (0.9); 7.4590 (1.0); 7.4438 (0.6); 7.4398 (0.5); 7.3305 (0.6); 7.3283 (0.7); 7.3051 (1.8); 7.2886 (1.4); 7.2860 (1.5); 7.2815 (0.6); 7.2700 (0.7); 7.2672 (0.6); 3.3630 (0.5); 3.3457 (0.8); 3.3289 (0.6); 3.3107 (22.3); 3.1750 (1.0); 3.1625 (1.0); 3.1356 (12.8); 2.5462 (0.9); 2.5230 (1.1); 2.5183 (1.4); 2.5096 (12.6); 2.5051 (25.9); 2.5005 (35.4); 2.4959 (24.2); 2.4913 (10.9); 1.7601 (16.0); 1.7132 (0.7);

1.7000 (0.7); 1.6554 (0.7); 1.6413 (0.6) 1.7000 (0.7); 1.6554 (0.7); 1.6413 (0.6)

1.156-124: 1 H-NMR(400.0 MHz, d6-DMSO):  1.156-124: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.6875 (5.2); 7.5361 (0.6); 7.5212 (0.5); 7.5152 (0.7); 7.4655 (0.9); 7.4609 (1.0); 7.4457 (0.6); 7.4417 (0.6); 7.3344 (0.6); 7.3322 (0.7); 7.3089 (1.8); 7.2925 (1.4); 7.2899 (1.5); 7.2852 (0.6); 7.2739 (0.8); 7.2711 (0.6); 3.3109 (26.9); 3.1751 (2.1); 3.1621 (2.0); 3.1380 (13.2); 2.5230 (0.8); 2.5183 (1.2); 2.5096 (13.0); 2.5050 (27.1); 2.5004δ = 8.6875 (5.2); 7.5361 (0.6); 7.5212 (0.5); 7.5152 (0.7); 7.4655 (0.9); 7.4609 (1.0); 7.4457 (0.6); 7.4417 (0.6); 7.3344 (0.6); 7.3322 (0.7); 7.3089 (1.8); 7.2925 (1.4); 7.2899 (1.5); 7.2852 (0.6); 7.2739 (0.8); 7.2711 (0.6); 3.3109 (26.9); 3.1751 (2.1); 3.1621 (2.0); 3.1380 (13.2); 2.5230 (0.8); 2.5183 (1.2); 2.5096 (13.0); 2.5050 (27.1); 2.5004

(37.3); 2.4959 (25.6); 2.4913 (11.5); 1.7627 (16.0); 1.4772 (0.8); 1.4666 (0.7); 1.2933 (0.8) (37.3); 2.4959 (25.6); 2.4913 (11.5); 1.7627 (16.0); 1.4772 (0.8); 1.4666 (0.7); 1.2933 (0.8)

1.156-152: 1 H-NMR(400.0 MHz, d6-DMSO):  1.156-152: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7027 (5.3); 7.5592 (0.6); 7.5410 (0.5); 7.5384 (0.7); 7.5248 (0.8); 7.5203 (0.8); 7.5063 (0.9); 7.5019 (1.0); 7.4865 (0.6); 7.4826 (0.5); 7.3586 (0.6); 7.3563 (0.7); 7.3377 (0.6); 7.3324 (2.0); 7.3143 (1.5); 7.3123 (2.0); 7.2959 (0.8); 7.2931 (0.6); 3.4283 (1.2); 3.4246 (1.1); 3.3264 (26.6); 3.1906 (1.6); 3.1778 (1.6); 3.1505 (13.2); 2.5385 (1.0); 2.5338 (1.4); 2.5251 (15.5); 2.5206 (32.5); 2.5160 (44.9); 2.5114 (30.8); 2.5068 (13.9); 1.7906 (16.0) 1.156- 167: 1 H-NMR(400.0 MHz, d6-DMSO): δ = 8.7027 (5.3); 7.5592 (0.6); 7.5410 (0.5); 7.5384 (0.7); 7.5248 (0.8); 7.5203 (0.8); 7.5063 (0.9); 7.5019 (1.0); 7.4865 (0.6); 7.4826 (0.5); 7.3586 (0.6); 7.3563 (0.7); 7.3377 (0.6); 7.3324 (2.0); 7.3143 (1.5); 7.3123 (2.0); 7.2959 (0.8); 7.2931 (0.6); 3.4283 (1.2); 3.4246 (1.1); 3.3264 (26.6); 3.1906 (1.6); 3.1778 (1.6); 3.1505 (13.2); 2.5385 (1.0); 2.5338 (1.4); 2.5251 (15.5); 2.5206 (32.5); 2.5160 (44.9); 2.5114 (30.8); 2.5068 (13.9); 1.7906 (16.0) 1.156-167: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.6772 (4.6); 7.5387 (0.6); 7.5179 (0.6); 7.5038 (0.7); 7.4993 (0.7); 7.4847 (0.8); 7.4802 (0.9); 7.4649 (0.5); 7.3333 (0.5); 7.3311 (0.6); 7.3124 (0.6); 7.3073 (1.8); 7.2897 (1.3); 7.2872 (1.8); 7.2711 (0.7); 7.2683 (0.6); 3.3106 (20.6); 3.1751 (1.2); 3.1620 (1.2); 3.1393 (12.0); 2.5229 (1.0); 2.5182 (1.3); 2.5095 (12.1); 2.5050 (24.8); 2.5004 (33.9); 2.4958 (23.2); 2.4913 (10.5); 1.7671 (16.0) δ = 8.6772 (4.6); 7.5387 (0.6); 7.5179 (0.6); 7.5038 (0.7); 7.4993 (0.7); 7.4847 (0.8); 7.4802 (0.9); 7.4649 (0.5); 7.3333 (0.5); 7.3311 (0.6); 7.3124 (0.6); 7.3073 (1.8); 7.2897 (1.3); 7.2872 (1.8); 7.2711 (0.7); 7.2683 (0.6); 3.3106 (20.6); 3.1751 (1.2); 3.1620 (1.2); 3.1393 (12.0); 2.5229 (1.0); 2.5182 (1.3); 2.5095 (12.1); 2.5050 (24.8); 2.5004 (33.9); 2.4958 (23.2); 2.4913 (10.5); 1.7671 (16.0)

1.157- 1 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.157-1: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.6087 (6.7); 7.6308 (0.8); 7.6216 (0.8); 7.5812 (0.6); 7.5658 (0.7); 7.5606 (1.4); 7.5452 (1.4); 7.5398 (1.0); 7.5244 (1.0); 7.4546 (1.2); 7.4522 (1.9); 7.4503 (1.3); 7.4342 (0.9); 7.4319 (1.3); 7.3583 (0.9); 7.3557 (0.9); 7.3357 (1.3); 7.3332 (1.1); 7.3149 (0.8); 7.3122 (0.7); 5.7529 (2.2); 3.3098 (81.6); 3.0808 (16.0); 2.6693 (0.6); 2.6109 (0.6); 2.6024 (1.0); 2.5928 (1.1); 2.5843 (0.7); 2.5748 (0.5); 2.5228 (2.1); 2.5182 (3.0); 2.5094 (30.8); 2.5049 (64.1); 2.5003δ = 8.6087 (6.7); 7.6308 (0.8); 7.6216 (0.8); 7.5812 (0.6); 7.5658 (0.7); 7.5606 (1.4); 7.5452 (1.4); 7.5398 (1.0); 7.5244 (1.0); 7.4546 (1.2); 7.4522 (1.9); 7.4503 (1.3); 7.4342 (0.9); 7.4319 (1.3); 7.3583 (0.9); 7.3557 (0.9); 7.3357 (1.3); 7.3332 (1.1); 7.3149 (0.8); 7.3122 (0.7); 5.7529 (2.2); 3.3098 (81.6); 3.0808 (16.0); 2.6693 (0.6); 2.6109 (0.6); 2.6024 (1.0); 2.5928 (1.1); 2.5843 (0.7); 2.5748 (0.5); 2.5228 (2.1); 2.5182 (3.0); 2.5094 (30.8); 2.5049 (64.1); 2.5003

(88.5) ; 2.4957 (59.8); 2.4911 (26.8); 2.3271 (0.5); 1.9877 (1.7); 1.7445 (8.0); 1.1745 (1.1); 1.1566 (0.5); 0.6205 (0.6); 0.6083 (1.6); 0.6027 (2.1); 0.5905 (2.1); 0.5848 (1.6); 0.5730 (0.7); 0.3991 (0.8); 0.3891 (1.8); 0.3823 (1.7); 0.3780(88.5); 2.4957 (59.8); 2.4911 (26.8); 2.3271 (0.5); 1.9877 (1.7); 1.7445 (8.0); 1.1745 (1.1); 1.1566 (0.5); 0.6205 (0.6); 0.6083 (1.6); 0.6027 (2.1); 0.5905 (2.1); 0.5848 (1.6); 0.5730 (0.7); 0.3991 (0.8); 0.3891 (1.8); 0.3823 (1.7); 0.3780

(1.6) ; 0.3726 (1.6); 0.3607 (0.5); -0.0002 (1.3) (1.6); 0.3726 (1.6); 0.3607 (0.5); -0.0002 (1.3)

1.157-101 : 1 H-NMR(400.0 MHz, d6-DMSO):  1.157-101: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7808 (16.0); 7.5953 (1.6); 7.5798 (1.7); 7.5746 (3.3); 7.5592 (3.4); 7.5538 (2.3); 7.5384 (2.3); 7.4687 (2.8); 7.4663 (4.6); 7.4643 (3.1); 7.4483 (2.2); 7.4460 (3.2); 7.3706 (2.1); 7.3680 (2.1); 7.3481 (3.2); 7.3272 (1.8); 7.3245δ = 8.7808 (16.0); 7.5953 (1.6); 7.5798 (1.7); 7.5746 (3.3); 7.5592 (3.4); 7.5538 (2.3); 7.5384 (2.3); 7.4687 (2.8); 7.4663 (4.6); 7.4643 (3.1); 7.4483 (2.2); 7.4460 (3.2); 7.3706 (2.1); 7.3680 (2.1); 7.3481 (3.2); 7.3272 (1.8); 7.3245

(1.7) ; 5.7530 (3.1); 4.0381 (0.7); 4.0203 (0.6); 3.3595 (1.2); 3.3499 (1.6); 3.3325 (3.0); 3.3096 (161.2); 3.1089 (37.3); 2.6740 (0.9); 2.6694 (1.3); 2.6648 (1.0); 2.6004 (1.6); 2.5462 (0.5); 2.5229 (4.9); 2.5182 (6.7); 2.5095 (67.4); 2.5050 (140.1); 2.5003 (193.1); 2.4958 (130.6); 2.4912 (58.4); 2.3318 (0.8); 2.3271 (1.2); 2.3225 (0.8); 1.9877 (3.1); 1.7726 (5.2); 1.7503 (5.1); 1.7192 (1.4); 1.7024 (2.1); 1.6872 (1.9); 1.6228 (1.5); 1.2364 (0.6); 1.1923 (0.9); 1.1745 (2.0);(1.7); 5.7530 (3.1); 4.0381 (0.7); 4.0203 (0.6); 3.3595 (1.2); 3.3499 (1.6); 3.3325 (3.0); 3.3096 (161.2); 3.1089 (37.3); 2.6740 (0.9); 2.6694 (1.3); 2.6648 (1.0); 2.6004 (1.6); 2.5462 (0.5); 2.5229 (4.9); 2.5182 (6.7); 2.5095 (67.4); 2.5050 (140.1); 2.5003 (193.1); 2.4958 (130.6); 2.4912 (58.4); 2.3318 (0.8); 2.3271 (1.2); 2.3225 (0.8); 1.9877 (3.1); 1.7726 (5.2); 1.7503 (5.1); 1.7192 (1.4); 1.7024 (2.1); 1.6872 (1.9); 1.6228 (1.5); 1.2364 (0.6); 1.1923 (0.9); 1.1745 (2.0);

1.1567 (0.9); -0.0002 (2.7) 1.1567 (0.9); -0.0002 (2.7)

1.157-152: 1 H-NMR(400.0 MHz, d6-DMSO):  1.157-152: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7815 (7.9); 8.6431 (2.4); 8.6336 (1.0); 8.2771 (1.8); 7.6013 (0.7); 7.5859 (0.8); 7.5806 (1.6); 7.5652 (1.8); 7.5598 (1.5); 7.5444 (1.4); 7.5224 (0.5); 7.4733 (2.2); 7.4529 (1.9); 7.4288 (0.7); 7.3796 (1.1); 7.3771 (1.2); 7.3571δ = 8.7815 (7.9); 8.6431 (2.4); 8.6336 (1.0); 8.2771 (1.8); 7.6013 (0.7); 7.5859 (0.8); 7.5806 (1.6); 7.5652 (1.8); 7.5598 (1.5); 7.5444 (1.4); 7.5224 (0.5); 7.4733 (2.2); 7.4529 (1.9); 7.4288 (0.7); 7.3796 (1.1); 7.3771 (1.2); 7.3571

(1.7) ; 7.3361 (1.2); 7.3334 (1.3); 7.3083 (0.5); 5.7529 (6.6); 5.2671 (2.5); 4.0381 (1.1); 4.0203 (1.1); 3.5865 (1.0); 3.5716 (0.5); 3.4253 (1.9); 3.3641 (1.2); 3.3124 (240.4); 3.2622 (2.1); 3.2442 (0.8); 3.2291 (0.7); 3.2106 (0.5); 3.1106 (17.9); 3.0887 (8.3); 3.0796 (1.6); 3.0465 (1.0); 2.6785 (0.8); 2.6740 (1.9); 2.6693 (2.7); 2.6647 (2.0); 2.6599 (0.8); 2.6128 (0.6); 2.5606 (1.3); 2.5560 (1.2); 2.5514 (0.8); 2.5228 (10.0); 2.5181 (14.0); 2.5094 (152.2); 2.5049 (317.6); 2.5003 (439.4); 2.4957 (298.5); 2.4911 (134.2); 2.4598 (1.4); 2.4552 (2.4); 2.4506 (3.3); 2.4461 (2.3); 2.3362 (1.0); 2.3317 (2.0); 2.3271 (2.8); 2.3223 (2.0); 2.3177 (0.9); 2.0720 (1.2); 1.9876 (5.2); 1.9311 (1.4); 1.7746 (16.0); 1.2367(1.7); 7.3361 (1.2); 7.3334 (1.3); 7.3083 (0.5); 5.7529 (6.6); 5.2671 (2.5); 4.0381 (1.1); 4.0203 (1.1); 3.5865 (1.0); 3.5716 (0.5); 3.4253 (1.9); 3.3641 (1.2); 3.3124 (240.4); 3.2622 (2.1); 3.2442 (0.8); 3.2291 (0.7); 3.2106 (0.5); 3.1106 (17.9); 3.0887 (8.3); 3.0796 (1.6); 3.0465 (1.0); 2.6785 (0.8); 2.6740 (1.9); 2.6693 (2.7); 2.6647 (2.0); 2.6599 (0.8); 2.6128 (0.6); 2.5606 (1.3); 2.5560 (1.2); 2.5514 (0.8); 2.5228 (10.0); 2.5181 (14.0); 2.5094 (152.2); 2.5049 (317.6); 2,5003 (439.4); 2.4957 (298.5); 2.4911 (134.2); 2.4598 (1.4); 2.4552 (2.4); 2.4506 (3.3); 2.4461 (2.3); 2.3362 (1.0); 2.3317 (2.0); 2.3271 (2.8); 2.3223 (2.0); 2.3177 (0.9); 2.0720 (1.2); 1.9876 (5.2); 1.9311 (1.4); 1.7746 (16.0); 1.2367

(1.8) ; 1.1923 (1.6); 1.1745 (3.2); 1.1566 (1.5); -0.0002 (6.6) (1.8); 1.1923 (1.6); 1.1745 (3.2); 1.1566 (1.5); -0.0002 (6.6)

1.157-167: 1 H-NMR(400.0 MHz, d6-DMSO):  1.157-167: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.7736 (16.0); 8.6360 (0.6); 7.5966 (1.5); 7.5810 (1.6); 7.5759 (3.1); 7.5605 (3.3); 7.5551 (2.4); 7.5397 (2.3); 7.4710 (2.6); 7.4686 (4.3); 7.4665 (3.0); 7.4506 (2.2); 7.4483 (3.2); 7.4461 (2.1); 7.3702 (2.0); 7.3676 (2.1); 7.3476 (3.0); 7.3451 (2.7); 7.3267 (1.9); 7.3240 (1.8); 5.7527 (6.0); 3.8688 (0.7); 3.7316 (1.7); 3.4099 (0.6); 3.3586 (1.2); 3.3413 (0.9); 3.3087 (238.9); 3.2590 (1.8); 3.1069 (36.9); 3.0919 (1.4); 2.6741 (1.8); 2.6694 (2.2); 2.6648 (1.7); 2.6600 (1.1); 2.6007 (1.6); 2.5897 (1.3); 2.5626 (1.0); 2.5578 (0.8); 2.5530 (0.7); 2.5476 (0.9); 2.5228 (7.9); 2.5181δ = 8.7736 (16.0); 8.6360 (0.6); 7.5966 (1.5); 7.5810 (1.6); 7.5759 (3.1); 7.5605 (3.3); 7.5551 (2.4); 7.5397 (2.3); 7.4710 (2.6); 7.4686 (4.3); 7.4665 (3.0); 7.4506 (2.2); 7.4483 (3.2); 7.4461 (2.1); 7.3702 (2.0); 7.3676 (2.1); 7.3476 (3.0); 7.3451 (2.7); 7.3267 (1.9); 7.3240 (1.8); 5.7527 (6.0); 3.8688 (0.7); 3.7316 (1.7); 3.4099 (0.6); 3.3586 (1.2); 3.3413 (0.9); 3.3087 (238.9); 3.2590 (1.8); 3.1069 (36.9); 3.0919 (1.4); 2.6741 (1.8); 2.6694 (2.2); 2.6648 (1.7); 2.6600 (1.1); 2.6007 (1.6); 2.5897 (1.3); 2.5626 (1.0); 2.5578 (0.8); 2.5530 (0.7); 2.5476 (0.9); 2.5228 (7.9); 2.5181

(10.6) ; 2.5094 (99.2); 2.5049 (204.2); 2.5003 (280.8); 2.4957 (188.9); 2.4911 (84.1); 2.4489 (0.7); 2.4443 (0.9); 2.4394 (0.8); 2.3364 (0.6); 2.3317 (1.2); 2.3270 (1.7); 2.3224 (1.3); 1.9876 (1.1); 1.7669 (10.2); 1.1745 (0.7); -0.0002(10.6); 2.5094 (99.2); 2.5049 (204.2); 2,5003 (280.8); 2.4957 (188.9); 2.4911 (84.1); 2.4489 (0.7); 2.4443 (0.9); 2.4394 (0.8); 2.3364 (0.6); 2.3317 (1.2); 2.3270 (1.7); 2.3224 (1.3); 1.9876 (1.1); 1.7669 (10.2); 1.1745 (0.7); -0.0002

(3-9) (3-9)

1.157-213: 1 H-NMR(400.0 MHz, d6-DMSO):  1.157-213: 1 H-NMR (400.0 MHz, d6-DMSO):

δ= 8.6969 (6.7); 8.5199 (1.0); 7.5770 (0.6); 7.5616 (0.7); 7.5564 (1.4); 7.5411 (1.4); 7.5356 (1.0); 7.5203 (0.9); 7.4490 (1.2); 7.4467 (1.9); 7.4287 (0.9); 7.4264 (1.4); 7.3502 (0.9); 7.3477 (0.9); 7.3275 (1.4); 7.3251 (1.2); 7.3068 (0.8); 7.3041 (0.8); 5.7525 (4.5); 4.1335 (3.6); 4.1197 (3.6); 3.3095 (74.8); 3.0953 (16.0); 2.5228 (1.9); 2.5181 (2.7); 2.5094 (28.2); 2.5048 (58.5); 2.5002 (80.7); 2.4956 (54.7); 2.4911 (24.5); 1.9876 (1.9); 1.7967 (13.3); 1.1923 (0.6);δ = 8.6969 (6.7); 8.5199 (1.0); 7.5770 (0.6); 7.5616 (0.7); 7.5564 (1.4); 7.5411 (1.4); 7.5356 (1.0); 7.5203 (0.9); 7.4490 (1.2); 7.4467 (1.9); 7.4287 (0.9); 7.4264 (1.4); 7.3502 (0.9); 7.3477 (0.9); 7.3275 (1.4); 7.3251 (1.2); 7.3068 (0.8); 7.3041 (0.8); 5.7525 (4.5); 4.1335 (3.6); 4.1197 (3.6); 3.3095 (74.8); 3.0953 (16.0); 2.5228 (1.9); 2.5181 (2.7); 2.5094 (28.2); 2.5048 (58.5); 2.5002 (80.7); 2.4956 (54.7); 2.4911 (24.5); 1.9876 (1.9); 1.7967 (13.3); 1.1923 (0.6);

1.1745 (1.2); 1.1566 (0.6); -0.0002 (1.4) 1.1745 (1.2); 1.1566 (0.6); -0.0002 (1.4)

1.169-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.169-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3600 (0.8); 7.3037 (2.3); 7.3022 (2.3); 7.2618 (6.9); 7.0258 (1.0); 7.0069 (1.2); 7.0051 (1.1); 6.9862 (0.9); 2.7026 (0.6); 2.6929 (0.6); 1.8318 (16.0); 1.5906 (2.0); 0.7828 (1.1); 0.7782 (1.1); 0.7729 (0.6); 0.7674 (0.6); 0.7617 (1.2); 0.7571 (1.1); 0.7464 (0.5); 0.7054 (0.9); 0.7018 (1.3); 0.6878 (1.2); 0.6839 (1.0); 0.6811 (0.6); 0.4466 (1.1); 0.4422 (1.2); 0.4339 (1.0); 0.4296 (1.2); 0.4020 (0.9); 0.3991 (1.0); 0.3955 (1.0); 0.3894 (0.9); 0.3858 (0.9); -0.0002δ = 7.3600 (0.8); 7.3037 (2.3); 7.3022 (2.3); 7.2618 (6.9); 7.0258 (1.0); 7.0069 (1.2); 7.0051 (1.1); 6.9862 (0.9); 2.7026 (0.6); 2.6929 (0.6); 1.8318 (16.0); 1.5906 (2.0); 0.7828 (1.1); 0.7782 (1.1); 0.7729 (0.6); 0.7674 (0.6); 0.7617 (1.2); 0.7571 (1.1); 0.7464 (0.5); 0.7054 (0.9); 0.7018 (1.3); 0.6878 (1.2); 0.6839 (1.0); 0.6811 (0.6); 0.4466 (1.1); 0.4422 (1.2); 0.4339 (1.0); 0.4296 (1.2); 0.4020 (0.9); 0.3991 (1.0); 0.3955 (1.0); 0.3894 (0.9); 0.3858 (0.9); -0.0002

(3-0) (3-0)

1.169-2: 1 H-NMR(400.0 MHz, CDCI3):  1.169-2: 1 H NMR (400.0 MHz, CDCl 3):

δ= 7.3608 (0.8); 7.2894 (2.3); 7.2878 (2.3); 7.2608 (11.3); 7.0275 (1.0); 7.0087 (1.1); 7.0066 (1.0); 6.9879 (0.9); 1.8070 (16.0); 1.2977 (6.5); 0.7815 (1.0); 0.7769 (1.1); 0.7716 (0.5); 0.7661 (0.6); 0.7604 (1.1); 0.7558 (1.0); 0.7451 (0.5); 0.6034 (1.2); 0.5933 (1.3); 0.5651 (1.6); 0.5560 (1.2); 0.5541 (1.3); 0.4443 (1.0); 0.4399 (1.1); 0.4316 (1.0);δ = 7.3608 (0.8); 7.2894 (2.3); 7.2878 (2.3); 7.2608 (11.3); 7.0275 (1.0); 7.0087 (1.1); 7.0066 (1.0); 6.9879 (0.9); 1.8070 (16.0); 1.2977 (6.5); 0.7815 (1.0); 0.7769 (1.1); 0.7716 (0.5); 0.7661 (0.6); 0.7604 (1.1); 0.7558 (1.0); 0.7451 (0.5); 0.6034 (1.2); 0.5933 (1.3); 0.5651 (1.6); 0.5560 (1.2); 0.5541 (1.3); 0.4443 (1.0); 0.4399 (1.1); 0.4316 (1.0);

0.4272 (1.1); -0.0002 (4.8) 0.4272 (1.1); -0.0002 (4.8)

1.169-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.169-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3204 (0.8); 7.2622 (7.7); 7.2097 (2.3); 7.2083 (2.2); 6.9780 (1.0); 6.9595 (1.1); 6.9570 (1.0); 6.9387 (0.8); 3.5128 (0.9); 2.5742 (1.0); 1.8084 (16.0); 1.7287 (0.6); 1.7168 (1.1); 1.7118 (1.9); 1.7047 (1.2); 1.6948 (0.5); 1.6073 (2.2); 0.7610 (1.0); 0.7563 (1.1); 0.7510 (0.5); 0.7456 (0.6); 0.7399 (1.1); 0.7352 (1.0); 0.4141 (1.1); 0.4096 (1.1);δ = 7.3204 (0.8); 7.2622 (7.7); 7.2097 (2.3); 7.2083 (2.2); 6.9780 (1.0); 6.9595 (1.1); 6.9570 (1.0); 6.9387 (0.8); 3.5128 (0.9); 2.5742 (1.0); 1.8084 (16.0); 1.7287 (0.6); 1.7168 (1.1); 1.7118 (1.9); 1.7047 (1.2); 1.6948 (0.5); 1.6073 (2.2); 0.7610 (1.0); 0.7563 (1.1); 0.7510 (0.5); 0.7456 (0.6); 0.7399 (1.1); 0.7352 (1.0); 0.4141 (1.1); 0.4096 (1.1);

0.4014 (1.0); 0.3969 (1.1); -0.0002 (3.2) 0.4014 (1.0); 0.3969 (1.1); -0.0002 (3.2)

1.169-152: 1 H-NMR(400.0 MHz, CDCI3):  1.169-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3361 (0.8); 7.2611 (10.9); 7.1956 (2.3); 7.1942 (2.3); 6.9903 (1.0); 6.9719 (1.1); 6.9695 (1.0); 6.9511 (0.9); 1.8257 (16.0); 1.5658 (3.1); 1.5646 (3.6); 0.7747 (1.0); 0.7701 (1.1); 0.7649 (0.5); 0.7593 (0.6); 0.7536 (1.1); 0.7491 (1.0); 0.4151 (1.1); 0.4108 (1.1); 0.4025 (1.0); 0.3982 (1.2); -0.0002 (4.7) 1.169-167: 1 H-NMR(400.0 MHz, CDCI3): δ = 7.3361 (0.8); 7.2611 (10.9); 7.1956 (2.3); 7.1942 (2.3); 6.9903 (1.0); 6.9719 (1.1); 6.9695 (1.0); 6.9511 (0.9); 1.8257 (16.0); 1.5658 (3.1); 1.5646 (3.6); 0.7747 (1.0); 0.7701 (1.1); 0.7649 (0.5); 0.7593 (0.6); 0.7536 (1.1); 0.7491 (1.0); 0.4151 (1.1); 0.4108 (1.1); 0.4025 (1.0); 0.3982 (1.2); -0.0002 (4.7) 1.169-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 7.3214 (0.7); 7.2619 (7.1); 7.1711 (2.1); 7.1695 (2.1); 6.9812 (0.9); 6.9627 (1.0); 6.9603 (0.9); 6.9419 (0.8); 1.8157 (16.0); 1.5884 (1.5); 0.7606 (1.0); 0.7559 (1.0); 0.7452 (0.5); 0.7395 (1.0); 0.7348 (0.9); 0.4175 (1.0); 0.4130δ = 7.3214 (0.7); 7.2619 (7.1); 7.1711 (2.1); 7.1695 (2.1); 6.9812 (0.9); 6.9627 (1.0); 6.9603 (0.9); 6.9419 (0.8); 1.8157 (16.0); 1.5884 (1.5); 0.7606 (1.0); 0.7559 (1.0); 0.7452 (0.5); 0.7395 (1.0); 0.7348 (0.9); 0.4175 (1.0); 0.4130

(1.0) ; 0.4048 (0.9); 0.4003 (1.0); -0.0002 (3.1) (1.0); 0.4048 (0.9); 0.4003 (1.0); -0.0002 (3.1)

1.172-1 : 1 H-NMR(400.0 MHz, CDCI3):  1.172-1: 1 H NMR (400.0 MHz, CDCl 3):

δ= 8.5380 (0.8); 8.5265 (0.8); 7.5245 (0.6); 7.5207 (0.9); 7.4995 (0.6); 7.4960 (0.5); 7.3358 (0.5); 7.3259 (0.7); 7.3244 (0.6); 7.3147 (0.9); 7.3050 (0.5); 7.3035 (0.5); 7.2604 (30.8); 2.6846 (0.6); 2.6751 (0.6); 2.0619 (0.5); 1.8285 (16.0); 1.5566 (10.6); 0.8637 (1.1); 0.8591 (1.1); 0.8537 (0.6); 0.8484 (0.6); 0.8426 (1.2); 0.8380 (1.1); 0.8273 (0.5); 0.7109 (0.9); 0.7073 (1.3); 0.6934 (1.2); 0.6894 (1.0); 0.6867 (0.5); 0.4930 (0.5); 0.4822 (1.1); 0.4778 (1.2); 0.4693δ = 8.5380 (0.8); 8.5265 (0.8); 7.5245 (0.6); 7.5207 (0.9); 7.4995 (0.6); 7.4960 (0.5); 7.3358 (0.5); 7.3259 (0.7); 7.3244 (0.6); 7.3147 (0.9); 7.3050 (0.5); 7.3035 (0.5); 7.2604 (30.8); 2.6846 (0.6); 2.6751 (0.6); 2.0619 (0.5); 1.8285 (16.0); 1.5566 (10.6); 0.8637 (1.1); 0.8591 (1.1); 0.8537 (0.6); 0.8484 (0.6); 0.8426 (1.2); 0.8380 (1.1); 0.8273 (0.5); 0.7109 (0.9); 0.7073 (1.3); 0.6934 (1.2); 0.6894 (1.0); 0.6867 (0.5); 0.4930 (0.5); 0.4822 (1.1); 0.4778 (1.2); 0.4693

(1.1) ; 0.4649 (1.2); 0.4177 (0.8); 0.4148 (0.9); 0.4111 (0.9); 0.4051 (0.9); 0.4015 (0.9); -0.0002 (13.4) (1.1); 0.4649 (1.2); 0.4177 (0.8); 0.4148 (0.9); 0.4111 (0.9); 0.4051 (0.9); 0.4015 (0.9); -0.0002 (13.4)

1.172-101 : 1 H-NMR(400.0 MHz, CDCI3):  1.172-101: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5325 (0.8); 8.5209 (0.8); 7.4855 (0.6); 7.4821 (0.9); 7.4612 (0.5); 7.4578 (0.5); 7.3125 (0.5); 7.3027 (0.6); 7.3010 (0.6); 7.2913 (0.9); 7.2818 (0.5); 7.2801 (0.5); 7.2702 (0.6); 7.2647 (9.3); 7.1616 (2.2); 7.1604 (2.2); 3.5210 (1.0); 2.9231 (0.6); 2.9070 (0.6); 2.6221 (0.9); 1.8311 (0.5); 1.8218 (16.0); 1.7211 (1.0); 1.7115 (1.1); 1.7040 (3.0); 1.6964 (1.1); 1.6869 (1.1); 1.6486 (1.0); 1.5872 (6.3); 1.2554 (1.0); 0.8380 (1.1); 0.8334 (1.1); 0.8280 (0.6); 0.8227 (0.6); 0.8170 (1.1); 0.8123 (1.1); 0.4330 (1.1); 0.4307 (0.8); 0.4285 (1.1); 0.4202 (1.0); 0.4156 (1.1); -0.0002 (4.0) 1.172-152: 1 H-NMR(400.0 MHz, CDCI3): δ = 8.5325 (0.8); 8.5209 (0.8); 7.4855 (0.6); 7.4821 (0.9); 7.4612 (0.5); 7.4578 (0.5); 7.3125 (0.5); 7.3027 (0.6); 7.3010 (0.6); 7.2913 (0.9); 7.2818 (0.5); 7.2801 (0.5); 7.2702 (0.6); 7.2647 (9.3); 7.1616 (2.2); 7.1604 (2.2); 3.5210 (1.0); 2.9231 (0.6); 2.9070 (0.6); 2.6221 (0.9); 1.8311 (0.5); 1.8218 (16.0); 1.7211 (1.0); 1.7115 (1.1); 1.7040 (3.0); 1.6964 (1.1); 1.6869 (1.1); 1.6486 (1.0); 1.5872 (6.3); 1.2554 (1.0); 0.8380 (1.1); 0.8334 (1.1); 0.8280 (0.6); 0.8227 (0.6); 0.8170 (1.1); 0.8123 (1.1); 0.4330 (1.1); 0.4307 (0.8); 0.4285 (1.1); 0.4202 (1.0); 0.4156 (1.1); -0.0002 (4.0) 1.172-152: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5395 (0.8); 8.5279 (0.8); 7.4952 (0.6); 7.4918 (0.9); 7.4709 (0.5); 7.4674 (0.5); 7.3275 (0.5); 7.3175 (0.6); 7.3161 (0.6); 7.3063 (0.9); 7.2951 (0.5); 7.2604 (32.9); 7.1526 (2.2); 7.1515 (2.2); 1.8328 (16.0); 1.5510 (12.5); 0.8499 (1.1); 0.8454 (1.1); 0.8400 (0.5); 0.8346 (0.6); 0.8288 (1.1); 0.8243 (1.0); 0.4356 (1.1); 0.4312 (1.1); 0.4229δ = 8.5395 (0.8); 8.5279 (0.8); 7.4952 (0.6); 7.4918 (0.9); 7.4709 (0.5); 7.4674 (0.5); 7.3275 (0.5); 7.3175 (0.6); 7.3161 (0.6); 7.3063 (0.9); 7.2951 (0.5); 7.2604 (32.9); 7.1526 (2.2); 7.1515 (2.2); 1.8328 (16.0); 1.5510 (12.5); 0.8499 (1.1); 0.8454 (1.1); 0.8400 (0.5); 0.8346 (0.6); 0.8288 (1.1); 0.8243 (1.0); 0.4356 (1.1); 0.4312 (1.1); 0.4229

(1.0); 0.4184 (1.1); -0.0002 (14.8) (1.0); 0.4184 (1.1); -0.0002 (14.8)

1.172-167: 1 H-NMR(400.0 MHz, CDCI3):  1.172-167: 1 H-NMR (400.0 MHz, CDCl 3):

δ= 8.5377 (0.7); 8.5261 (0.7); 7.4890 (0.6); 7.4855 (0.9); 7.4646 (0.5); 7.4612 (0.5); 7.3054 (0.6); 7.3039 (0.5); 7.2942 (0.7); 7.2634 (12.0); 7.1254 (1.9); 7.1244 (1.9); 2.9183 (0.9); 1.8314 (16.0); 1.6124 (1.3); 1.6020 (4.7); 1.2846 (0.5); 1.2552 (1.1); 0.8446 (0.5); 0.8337 (1.0); 0.8290 (1.2); 0.8236 (0.6); 0.8183 (0.6); 0.8126 (1.1); 0.8080 (1.0); 0.7973 (0.5); 0.4358 (1.0); 0.4313 (1.1); 0.4230 (1.1); 0.4185 (1.2); -0.0002 (5.0) δ = 8.5377 (0.7); 8.5261 (0.7); 7.4890 (0.6); 7.4855 (0.9); 7.4646 (0.5); 7.4612 (0.5); 7.3054 (0.6); 7.3039 (0.5); 7.2942 (0.7); 7.2634 (12.0); 7.1254 (1.9); 7.1244 (1.9); 2.9183 (0.9); 1.8314 (16.0); 1.6124 (1.3); 1.6020 (4.7); 1.2846 (0.5); 1.2552 (1.1); 0.8446 (0.5); 0.8337 (1.0); 0.8290 (1.2); 0.8236 (0.6); 0.8183 (0.6); 0.8126 (1.1); 0.8080 (1.0); 0.7973 (0.5); 0.4358 (1.0); 0.4313 (1.1); 0.4230 (1.1); 0.4185 (1.2); -0.0002 (5.0)

Gegenstand der vorliegenden Erfindung ist weiterhin die Verwendung einer oder mehrerer The present invention furthermore relates to the use of one or more

Verbindungen der allgemeinen Formel (I) und/oder deren Salzen, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (L I) bis (1.182) und/oder deren Salze, jeweils wie oben definiert, Compounds of general formula (I) and / or their salts, as defined above, preferably in one of the preferred or particularly preferred embodiment, in particular one or more compounds of formulas (LI) to (1.182) and / or salts thereof, each as defined above,

als Herbizid und/oder Pflanzenwachstumsregulator, vorzugsweise in Kulturen von Nutz- und/oder Zierpflanzen. as a herbicide and / or plant growth regulator, preferably in crops of useful and / or ornamental plants.

Gegenstand der vorliegenden Erfindung ist ferner ein Verfahren zur Bekämpfung von Schadpflanzen und/oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass eine wirksame Menge einer oder mehrerer Verbindungen der allgemeinen Formel (I) und/oder deren Salzen, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten The present invention furthermore relates to a method for controlling harmful plants and / or for regulating the growth of plants, characterized in that an effective amount of one or more compounds of the general formula (I) and / or their salts, as defined above, preferably in one which is characterized as being preferred or particularly preferred

Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (L I) bis (1.182) und/oder deren Salze, jeweils wie oben definiert, oder eines erfindungsgemäßen Mittels, wie nachstehend definiert, auf die (Schad)Pflanzen, (Schad)Pflanzensamen, den Boden, in dem oder auf dem die (Schad)Pflanzen wachsen, oder die Anbaufläche appliziert wird. Embodiment, in particular one or more compounds of the formulas (LI) to (1.182) and / or salts thereof, each as defined above, or an agent according to the invention, as defined below, on the (harmful) plants, (harmful) plant seeds, the soil , in which or on which the (harmful) plants grow, or the cultivated area is applied.

Gegenstand der vorliegenden Erfindung ist auch ein Verfahren zur Bekämpfung von unerwünschten Pflanzen, vorzugsweise in Nutzpflanzenkulturen, dadurch gekennzeichnet, dass eine wirksame Meng einer oder mehrerer Verbindungen der allgemeinen Formel (I) und/oder deren Salzen, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten The present invention also provides a method for controlling undesirable plants, preferably in crops, characterized in that an effective amount one or more compounds of general formula (I) and / or their salts, as defined above, preferably in one of the preferred or particularly preferred

Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der Formeln (L I) bis (1.182) und/oder deren Salze, jeweils wie oben definiert, oder eines erfindungsgemäßen Mittels, wie nachstehend definiert, auf unerwünschte Pflanzen (z.B. Schadpflanzen wie mono- oder dikotyle Unkräuter oder unerwünschte Kulturpflanzen), das Saatgut der unerwünschten Pflanzen (d.h. Pflanzensamen, z.B. Körner, Samen oder vegetative Vermehrungsorgane wie Knollen oder Sprossteile mit Knospen), den Boden, in dem oder auf dem die unerwünschte Pflanzen wachsen, (z.B. den Boden von Kulturland oder Nicht-Kulturland) oder die Anbaufläche (d.h. Fläche, auf der die unerwünschte Pflanzen wachsen werden) appliziert wird. Embodiment, in particular one or more compounds of formulas (LI) to (1.182) and / or their salts, each as defined above, or an agent according to the invention, as defined below, on undesirable plants (eg harmful plants such as mono- or dicotyledonous weeds or unwanted Crops), the seed of the undesirable plants (ie, plant seeds, eg, grains, seeds or vegetative propagules such as tubers or sprouts with buds), the soil in which or on which the undesirable plants grow (eg, the soil of cultivated land or non-cultivated land ) or the area under cultivation (ie area on which the unwanted plants will grow) is applied.

Gegenstand der vorliegenden Erfindung ist ferner auch Verfahren zur Bekämpfung zur The present invention is also a method for controlling

Wachstumsregulierung von Pflanzen, vorzugsweise von Nutzpflanzen, dadurch gekennzeichnet, dass eine wirksame Menge einer oder mehrerer Verbindungen der allgemeinen Formel (I) und/oder deren Salzen, wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten Growth regulation of plants, preferably of useful plants, characterized in that an effective amount of one or more compounds of general formula (I) and / or their salts, as defined above, preferably in one of the preferred or particularly preferred

Ausgestaltung, insbesondere einer oder mehrerer Verbindungen der allgemeinen Formeln (L I) bis (1.182) und/oder deren Salze, jeweils wie oben definiert, oder eines erfindungsgemäßen Mittels, wie nachstehend definiert, die Pflanze, das Saatgut der Pflanze (d.h. Pflanzensamen, z.B. Körner, Samen oder vegetative Embodiment, in particular one or more compounds of the general formulas (LI) to (1.182) and / or salts thereof, each as defined above, or an agent according to the invention, as defined below, the plant, the seed of the plant (ie plant seeds, eg grains , Seeds or vegetative

Vermehrungsorgane wie Knollen oder Sprossteile mit Knospen), den Boden, in dem oder auf dem die Pflanzen wachsen, (z.B. den Boden von Kulturland oder Nicht-Kulturland) oder die Anbaufläche (d.h. Fläche, auf der die Pflanzen wachsen werden) appliziert wird. Propagating organs such as tubers or sprouts with buds), the soil in which or on which the plants grow (e.g., the soil of cultivated land or non-cultivated land) or the cultivated area (i.e., area on which the plants will grow) is applied.

Dabei können die erfindungsgemäßen Verbindungen bzw. die erfindungsgemäßen Mittel z.B. im Vorsaat- (ggf. auch durch Einarbeitung in den Boden), Vorauflauf- und/oder Nachauflaufverfahren ausgebracht werden. Im einzelnen seien beispielhaft einige Vertreter der mono- und dikotylen The compounds according to the invention or the agents according to the invention may e.g. in Vorsaat- (possibly also by incorporation into the soil), pre-emergence and / or Nachauflaufverfahren be applied. In particular, some representatives of mono- and dicots

Unkrautflora genannt, die durch die die erfindungsgemäßen Verbindungen kontrolliert werden können, ohne dass durch die Nennung eine Beschränkung auf bestimmte Arten erfolgen soll. Vorzugsweise werden in einem erfindungsgemäßen Verfahren zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen eine oder mehrere Verbindungen der allgemeinen Formel (I) und/oder deren Salze zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung in Kulturen von Nutzpflanzen oder Zierpflanzen eingesetzt, wobei die Nutzpflanzen oder Zierpflanzen in einer bevorzugten Ausgestaltung transgene Pflanzen sind. Called weed flora, which can be controlled by the compounds of the invention, without the mention should be limited to certain species. Preferably, in a method according to the invention for controlling harmful plants or for regulating the growth of plants, one or more compounds of the general formula (I) and / or their salts are employed for controlling harmful plants or regulating growth in crops of crops or ornamental plants, the crops or ornamentals in a preferred embodiment are transgenic plants.

Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze eignen sich zur Bekämpfung der folgenden Gattungen von monokotylen und dikotylen Schadpflanzen: The compounds of the general formula (I) according to the invention and / or salts thereof are suitable for controlling the following genera of monocotyledonous and dicotyledonous harmful plants:

Monokotyle Schadpflanzen der Gattungen: Aegilops, Agropyron, Agrostis, Alopecurus, Apera, Avena, Brachiaria, Bromus, Cenchrus, Commelina, Cynodon, Cyperus, Dactyloctenium, Digitaria, Echinochloa, Eleocharis, Eleusine, Eragrostis, Eriochloa, Festuca, Fimbristylis, Heteranthera, Imperata, Ischaemum, Leptochloa, Lolium, Monochoria, Panicum, Paspalum, Phalaris, Phleum, Poa, Rottboellia, Sagittaria, Scirpus, Setaria, Sorghum. Monocotyledonous weeds of the genera: Aegilops, Agropyron, Agrostis, Alopecurus, Apera, Avena, Brachiaria, Bromus, Cenchrus, Commelina, Cynodon, Cyperus, Dactyloctenium, Digitaria, Echinochloa, Eleocharis, Eleusine, Eragrostis, Eriochloa, Festuca, Fimbristylis, Heteranthera, Imperata , Ishumum, Leptochloa, Lolium, Monochoria, Panicum, Paspalum, Phalaris, Phleum, Poa, Rottboellia, Sagittaria, Scirpus, Setaria, Sorghum.

Dikotyle Schadpflanzen der Gattungen: Abutilon, Amaranthus, Ambrosia, Anoda, Anthemis, Aphanes, Artemisia, Atriplex, Bellis, Bidens, Capsella, Carduus, Cassia, Centaurea, Chenopodium, Cirsium, Convolvulus, Datura, Desmodium, Emex, Erysimum, Euphorbia, Galeopsis, Galinsoga, Galium, Hibiscus, Ipomoea, Kochia, Lamium, Lepidium, Lindernia, Matricaria, Mentha, Mercurialis, Mullugo, Myosotis, Papaver, Pharbitis, Plantago, Polygonum, Portulaca, Ranunculus, Raphanus, Rorippa, Rotala, Rumex, Salsola, Senecio, Sesbania, Sida, Sinapis, Solanum, Sonchus, Sphenoclea, Stellaria, Taraxacum, Thlaspi, Trifolium, Urtica, Veronica, Viola, Xanthium.  Dicotyledonous weeds of the genera: Abutilon, Amaranthus, Ambrosia, Anoda, Anthemis, Aphanes, Artemisia, Atriplex, Bellis, Bidens, Capsella, Carduus, Cassia, Centaurea, Chenopodium, Cirsium, Convolvulus, Datura, Desmodium, Emex, Erysimum, Euphorbia, Galeopsis Galinsoga Galium Hibiscus Ipomoea Kochia Lamium Lepidium Lindernia Matricaria Mentha Mercurialis Mullugo Myosotis Papaver Pharbitis Plantago Polygonum Portulaca Ranunculus Raphanus Rorippa Rotala Rumex , Sesbania, Sida, Sinapis, Solanum, Sonchus, Sphenoclea, Stellaria, Taraxacum, Thlaspi, Trifolium, Urtica, Veronica, Viola, Xanthium.

Werden die erfindungsgemäßen Verbindungen vor dem Keimen der Schadpflanzen (Ungräser und/oder Unkräuter) auf die Erdoberfläche appliziert (Vorauflaufverfahren), so wird entweder das Auflaufen der Ungras- bzw. Unkrautkeimlinge vollständig verhindert oder diese wachsen bis zum Keimblattstadium heran, stellen jedoch dann ihr Wachstum ein und sterben schließlich nach Ablauf von drei bis vier Wochen vollkommen ab. If the compounds according to the invention are applied to the surface of the earth (weeds and / or weeds) prior to germination (pre-emergence method), either the emergence of the weed seedlings or weed seedlings is completely prevented or they grow up to the cotyledon stage, but then grow and eventually die off after three to four weeks.

Bei Applikation der Wirkstoffe auf die grünen Pflanzenteile im Nachauflaufverfahren tritt nach der Behandlung Wachstumsstop ein und die Schadpflanzen bleiben in dem zum Applikationszeitpunkt vorhandenen Wachstumsstadium stehen oder sterben nach einer gewissen Zeit ganz ab, so dass auf diese Weise eine für die Kulturpflanzen schädliche Unkrautkonkurrenz sehr früh und nachhaltig beseitigt wird. When the active ingredients are applied to the green parts of the plants postemergence, growth stops after the treatment and the harmful plants remain in the growth stage existing at the time of application or die completely after a certain time, so that a weed competition harmful to the crop plants takes place very early and sustainably eliminated.

Obgleich die erfindungsgemäßen Verbindungen eine ausgezeichnete herbizide Aktivität gegenüber mono- und dikotylen Unkräutern aufweisen, werden Kulturpflanzen wirtschaftlich bedeutender Kulturen z.B. dikotyler Kulturen der Gattungen Arachis, Beta, Brassica, Cucumis, Cucurbita, Helianthus, Daucus, Glycine, Gossypium, Ipomoea, Lactuca, Linum, Lycopersicon, Miscanthus, Nicotiana, Phaseolus, Pisum, Solanum, Vicia, oder monokotyler Kulturen der Gattungen Allium, Ananas, Asparagus, Avena, Hordeum, Oryza, Panicum, Saccharum, Seeale, Sorghum, Triticale, Triticum, Zea, abhängig von der Struktur der jeweiligen erfindungsgemäßen Verbindung und deren Aufwandmenge nur unwesentlich oder gar nicht geschädigt. Die vorliegenden Verbindungen eignen sich aus diesen Gründen sehr gut zur selektiven Bekämpfung von unerwünschtem Pflanzenwuchs in Pflanzenkulturen wie Although the compounds according to the invention have excellent herbicidal activity against monocotyledonous and dicotyledonous weeds, crops of economically important crops, eg dicotyledonous crops of the genera Arachis, Beta, Brassica, Cucumis, Cucurbita, Helianthus, Daucus, Glycine, Gossypium, Ipomoea, Lactuca, Linum, Lycopersicon, Miscanthus, Nicotiana, Phaseolus, Pisum, Solanum, Vicia, or monocotylic cultures of the genera Allium, pineapple, asparagus, Avena, Hordeum, Oryza, Panicum, Saccharum, Seeale, Sorghum, Triticale, Triticum, Zea, depending on the structure of the respective compound of the invention and their application rate only insignificantly or not damaged at all. For these reasons, the present compounds are very well suited for the selective control of undesired plant growth in crops such as

landwirtschaftlichen Nutzpflanzungen oder Zierpflanzungen. agricultural crops or ornamental plantings.

Darüberhinaus weisen die erfindungsgemäßen Verbindungen (abhängig von ihrer jeweiligen Struktur und der ausgebrachten Aufwandmenge) hervorragende wachstumsregulatorische Eigenschaften bei Kulturpflanzen auf. Sie greifen regulierend in den pflanzeneigenen Stoffwechsel ein und können damit zur gezielten Beeinflussung von Pflanzeninhaltsstoffen und zur Ernteerleichterung wie z.B. durch Auslösen von Desikkation und Wuchsstauchung eingesetzt werden. Desweiteren eignen sie sich auch zur generellen Steuerung und Hemmung von unerwünschtem vegetativem Wachstum, ohne dabei die Pflanzen abzutöten. Eine Hemmung des vegetativen Wachstums spielt bei vielen mono- und dikotylen Kulturen eine große Rolle, da beispielsweise die Lagerbildung hierdurch verringert oder völlig verhindert werden kann. In addition, the compounds according to the invention (depending on their respective structure and the applied application rate) have excellent growth-regulatory properties in crop plants. They regulate the plant's metabolism and can thus be used to specifically influence plant constituents and facilitate harvesting, such as be used by triggering desiccation and stunted growth. Furthermore, they are also suitable for the general control and inhibition of unwanted vegetative growth, without killing the plants. Inhibition of vegetative growth plays an important role in many monocotyledonous and dicotyledonous crops, since, for example, storage formation can thereby be reduced or completely prevented.

Aufgrund ihrer herbiziden und pflanzenwachstumsregulatorischen Eigenschaften können die Wirkstoffe auch zur Bekämpfung von Schadpflanzen in Kulturen von gentechnisch oder durch konventionelle Mutagenese veränderten Pflanzen eingesetzt werden. Die transgenen Pflanzen zeichnen sich in der Regel durch besondere vorteilhafte Eigenschaften aus, beispielsweise durch Resistenzen gegenüber bestimmten Pestiziden, vor allem bestimmten Herbiziden, Resistenzen gegenüber Pflanzenkrankheiten oder Erregern von Pflanzenkrankheiten wie bestimmten Insekten oder Mikroorganismen wie Pilzen, Bakterien oder Viren. Andere besondere Eigenschaften betreffen z.B. das Erntegut hinsichtlich Menge, Qualität, Lagerfähigkeit, Zusammensetzung und spezieller Inhaltsstoffe. So sind transgene Pflanzen mit erhöhtem Stärkegehalt oder veränderter Qualität der Stärke oder solche mit anderer Because of their herbicidal and plant growth regulatory properties, the active compounds can also be used to control harmful plants in crops of genetically engineered or conventional mutagenized plants. The transgenic plants are usually characterized by particular advantageous properties, for example by resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria or viruses. Other special properties concern e.g. the crop in terms of quantity, quality, shelf life, composition and special ingredients. So are transgenic plants with increased starch content or altered quality of starch or those with others

Fettsäurezusammensetzung des Ernteguts bekannt. Fatty acid composition of the crop known.

Bevorzugt bezüglich transgener Kulturen ist die Anwendung der erfindungsgemäßen Verbindungen und/oder deren Salze in wirtschaftlich bedeutenden transgenen Kulturen von Nutz und Zierpflanzen, z.B. von Getreide wie Weizen, Gerste, Roggen, Hafer, Hirse, Reis und Mais oder auch Kulturen von Zuckerrübe, Baumwolle, Soja, Raps, Kartoffel, Tomate, Erbse und anderen Gemüsesorten. Preferred for transgenic cultures is the use of the compounds of the invention and / or their salts in economically important transgenic crops of useful and ornamental plants, e.g. of cereals such as wheat, barley, rye, oats, millet, rice and maize or also crops of sugar beet, cotton, soya, rapeseed, potato, tomato, pea and other vegetables.

Vorzugsweise können die erfindungsgemäßen Verbindungen auch als Herbizide in Preferably, the compounds of the invention may also be used as herbicides in

Nutzpflanzenkulturen eingesetzt werden, welche gegenüber den phytotoxischen Wirkungen der Herbizide resistent sind bzw. gentechnisch resistent gemacht worden sind. Aufgrand ihrer herbiziden und pflanzenwachstumsregulatorischen Eigenschaften können die Wirkstoffe auch zur Bekämpfung von Schadpflanzen in Kulturen von bekannten oder noch zu entwickelnden gentechnisch veränderten Pflanzen eingesetzt werden. Die transgenen Pflanzen zeichnen sich in der Regel durch besondere vorteilhafte Eigenschaften aus, beispielsweise durch Resistenzen gegenüber bestimmten Pestiziden, vor allem bestimmten Herbiziden, Resistenzen gegenüber Pflanzenkrankheiten oder Erregern von Pflanzenkrankheiten wie bestimmten Insekten oder Mikroorganismen wie Pilzen, Bakterien oder Viren. Andere besondere Eigenschaften betreffen z.B. das Erntegut hinsichtlich Menge, Qualität, Lagerfähigkeit, Zusammensetzung und spezieller Inhaltsstoffe. So sind transgene Pflanzen mit erhöhtem Stärkegehalt oder veränderter Qualität der Stärke oder solche mit anderer Crop plants are used, which are resistant to the phytotoxic effects of herbicides or have been made genetically resistant. Based on their herbicidal and plant growth regulatory properties, the active compounds can also be used for controlling harmful plants in crops of known or yet to be developed genetically modified plants. The transgenic plants are usually characterized by particular advantageous properties, for example by resistance to certain pesticides, especially certain herbicides, resistance to plant diseases or pathogens of plant diseases such as certain insects or microorganisms such as fungi, bacteria or viruses. Other special properties concern, for example, the crop in terms of quantity, quality, shelf life, composition and special ingredients. So are transgenic plants with increased starch content or altered quality of starch or those with others

Fettsäurezusammensetzung des Ernteguts bekannt. Weitere besondere Eigenschaften können in einer Toleranz oder Resistenz gegen abiotische Stressoren z.B. Hitze, Kälte, Trockenheit, Salz und ultraviolette Strahlung liegen. Fatty acid composition of the crop known. Other particular properties may include tolerance or resistance to abiotic stressors, e.g. Heat, cold, drought, salt and ultraviolet radiation are present.

Bevorzugt ist die Anwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) oder deren Salze in wirtschaftlich bedeutenden transgenen Kulturen von Nutz-und Zierpflanzen, z.B. von Getreide wie Weizen, Gerste, Roggen, Hafer, Triticale, Hirse, Reis, Maniok und Mais oder auch Kulturen von Zuckerrübe, Baumwolle, Soja, Raps, Kartoffel, Tomate, Erbse und anderen Gemüsesorten. Preference is given to the use of the compounds of general formula (I) according to the invention or their salts in economically important transgenic crops of useful and ornamental plants, e.g. of cereals such as wheat, barley, rye, oats, triticale, millet, rice, manioc and maize or also crops of sugar beet, cotton, soya, rapeseed, potato, tomato, pea and other vegetables.

Vorzugsweise können die Verbindungen der allgemeinen Formel (I) als Herbizide in Preferably, the compounds of general formula (I) as herbicides in

Nutzpflanzenkulturen eingesetzt werden, welche gegenüber den phytotoxischen Wirkungen der Herbizide resistent sind bzw. gentechnisch resistent gemacht worden sind. Crop plants are used, which are resistant to the phytotoxic effects of herbicides or have been made genetically resistant.

Herkömmliche Wege zur Herstellung neuer Pflanzen, die im Vergleich zu bisher vorkommenden Pflanzen modifizierte Eigenschaften aufweisen, bestehen beispielsweise in klassischen Conventional ways of producing new plants which have modified properties in comparison with previously occurring plants consist, for example, in classical methods

Züchtungsverfahren und der Erzeugung von Mutanten. Alternativ können neue Pflanzen mit veränderten Eigenschaften mit Hilfe gentechnischer Verfahren erzeugt werden. Breeding methods and the generation of mutants. Alternatively, new plants with altered properties can be generated using genetic engineering techniques.

Zahlreiche molekularbiologische Techniken, mit denen neue transgene Pflanzen mit veränderten Eigenschaften hergestellt werden können, sind dem Fachmann bekannt. Für derartige gentechnische Manipulationen können Nucleinsäuremoleküle in Plasmide eingebracht werden, die eine Mutagenese oder eine Sequenzveränderang durch Rekombination von DNA-Sequenzen erlauben. Mit Hilfe von Standardverfahren können z.B. Basenaustausche vorgenommen, Teilsequenzen entfernt oder natürliche oder synthetische Sequenzen hinzugefügt werden. Für die Verbindung der DNA-Fragmente Numerous molecular biological techniques with which new transgenic plants with altered properties can be prepared are known to the person skilled in the art. For such genetic manipulations, nucleic acid molecules can be introduced into plasmids that allow for mutagenesis or sequence alteration by recombination of DNA sequences. By means of standard methods, e.g. Base exchanges are made, partial sequences removed or natural or synthetic sequences added. For the connection of the DNA fragments

untereinander können an die Fragmente Adaptoren oder Linker angesetzt werden. between them adapters or linkers can be attached to the fragments.

Die Herstellung von Pflanzenzellen mit einer verringerten Aktivität eines Genprodukts kann The production of plant cells with reduced activity of a gene product can

beispielsweise erzielt werden durch die Expression mindestens einer entsprechenden antisense-RNA, einer sense-RNA zur Erzielung eines Cosuppressionseffektes oder die Expression mindestens eines entsprechend konstruierten Ribozyms, das spezifisch Transkripte des obengenannten Genprodukts spaltet. Hierzu können zum einen DNA-Moleküle verwendet werden, die die gesamte codierende Sequenz eines Genprodukts einschließlich eventuell vorhandener flankierender Sequenzen umfassen, als auch DNA- Moleküle, die nur Teile der codierenden Sequenz umfassen, wobei diese Teile lang genug sein müssen, um in den Zellen einen antisense-Effekt zu bewirken. Möglich ist auch die Verwendung von DNA- Sequenzen, die einen hohen Grad an Homologie zu den codiereden Sequenzen eines Genprodukts aufweisen, aber nicht vollkommen identisch sind. For example, be achieved by the expression of at least one corresponding antisense RNA, a sense RNA to obtain a cosuppression effect or the expression of at least one appropriately engineered ribozyme which specifically cleaves transcripts of the above gene product. For this purpose, on the one hand DNA molecules can be used which comprise the entire coding sequence of a gene product including any flanking sequences, as well as DNA molecules which comprise only parts of the coding sequence, which parts have to be long enough to be present in the cells to cause an antisense effect. It is also possible to use DNA sequences which have a high degree of homology to the coding sequences of a gene product, but are not completely identical.

Bei der Expression von Nucleinsäuremolekülen in Pflanzen kann das synthetisierte Protein in jedem beliebigen Kompartiment der pflanzlichen Zelle lokalisiert sein. Um aber die Lokalisation in einem bestimmten Kompartiment zu erreichen, kann z.B. die codierende Region mit DNA-Sequenzen verknüpft werden, die die Lokalisierung in einem bestimmten Kompartiment gewährleisten. Derartige Sequenzen sind dem Fachmann bekannt (siehe beispielsweise Braun et al., EMBO J. 11 (1992), 3219- 3227). Die Expression der Nukleinsäuremoleküle kann auch in den Organellen der Pflanzenzellen stattfinden. Die transgenen Pflanzenzellen können nach bekannten Techniken zu ganzen Pflanzen regeneriert werden. Bei den transgenen Pflanzen kann es sich prinzipiell um Pflanzen jeder beliebigen In the expression of nucleic acid molecules in plants, the synthesized protein may be located in any compartment of the plant cell. However, to achieve localization in a particular compartment, e.g. the coding region is linked to DNA sequences which ensure localization in a particular compartment. Such sequences are known to the person skilled in the art (see, for example, Braun et al., EMBO J. 11 (1992), 3219-3227). The expression of the nucleic acid molecules can also take place in the organelles of the plant cells. The transgenic plant cells can be regenerated to whole plants by known techniques. The transgenic plants can in principle be plants of any one

Pflanzenspezies handeln, d.h. sowohl monokotyle als auch dikotyle Pflanzen. Plant species, i. both monocotyledonous and dicotyledonous plants.

So sind transgene Pflanzen erhältlich, die veränderte Eigenschaften durch Überexpression, Suppression oder Inhibierung homologer (= natürlicher) Gene oder Gensequenzen oder Expression heterologer (= fremder) Gene oder Gensequenzen aufweisen. Thus, transgenic plants are available which have altered properties by overexpression, suppression or inhibition of homologous (= natural) genes or gene sequences or expression of heterologous (= foreign) genes or gene sequences.

Vorzugsweise können die erfindungsgemäßen Verbindungen (I) in transgenen Kulturen eingesetzt werden, welche gegen Wuchsstoffe, wie z.B. Dicamba oder gegen Herbizide, die essentielle Preferably, the compounds (I) according to the invention can be used in transgenic cultures which are resistant to growth factors, such as e.g. Dicamba or against herbicides, the essential

Pflanzenenzyme, z.B. Acetolactatsynthasen (ALS), EPSP Synthasen, Glutaminsynthasen (GS) oderPlant enzymes, e.g. Acetolactate synthases (ALS), EPSP synthases, glutamine synthases (GS) or

Hydoxyphenylpyruvat Dioxygenasen (HPPD) hemmen, respektive gegen Herbizide aus der Gruppe der Sulfonylharnstoffe, der Glyphosate, Glufosinate oder Benzoylisoxazole und analogen Wirkstoffe, resistent sind. Bei der Anwendung der erfindungsgemäßen Wirkstoffe in transgenen Kulturen treten neben den in anderen Kulturen zu beobachtenden Wirkungen gegenüber Schadpflanzen oftmals Wirkungen auf, die für die Applikation in der jeweiligen transgenen Kultur spezifisch sind, beispielsweise ein verändertes oder speziell erweitertes Unkrautspektrum, das bekämpft werden kann, veränderte Aufwandmengen, die für die Applikation eingesetzt werden können, vorzugsweise gute Kombinierbarkeit mit den Herbiziden, gegenüber denen die transgene Kultur resistent ist, sowie Beeinflussung von Wuchs und Ertrag der transgenen Kulturpflanzen. Hydoxyphenylpyruvate dioxygenases (HPPD), respectively, are resistant to herbicides from the group of sulfonylureas, the glyphosate, glufosinate or benzoylisoxazole and analogues. In the application of the active compounds according to the invention in transgenic crops, in addition to the effects observed in other crops against harmful plants, effects which are specific for the application in the respective transgenic crop often occur, for example a changed one or specially extended weed spectrum that can be controlled, modified application rates that can be used for the application, preferably good compatibility with the herbicides to which the transgenic culture is resistant, and influencing the growth and yield of the transgenic crops.

Gegenstand der Erfindung ist deshalb auch die Verwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) und/oder deren Salze als Herbizide zur Bekämpfung von Schadpflanzen in Kulturen von Nutz- oder Zierpflanzen, gegebenenfalls in transgenen Kulturpflanzen. Bevorzugt ist die Verwendung in Getreide, dabei vorzugsweise Mais, Weizen, Gerste, Roggen, Hafer, Hirse, oder Reis, im Vor- oder Nachauflauf. The invention therefore also relates to the use of the compounds of the general formula (I) according to the invention and / or salts thereof as herbicides for controlling harmful plants in crops of useful or ornamental plants, optionally in transgenic crop plants. Preferred is the use in cereals, preferably corn, wheat, barley, rye, oats, millet, or rice, in the pre- or post-emergence.

Bevorzugt ist auch die Verwendung in Soja im Vor- oder Nachauflauf. Die erfindungsgemäße Verwendung zur Bekämpfung von Schadpflanzen oder zur Preference is also the use in soy in the pre or postemergence. The use according to the invention for controlling harmful plants or for

Wachstumsregulierung von Pflanzen schließt auch den Fall ein, bei dem der Wirkstoff der allgemeinen Formel (I) oder dessen Salz erst nach der Ausbringung auf der Pflanze, in der Pflanze oder im Boden aus einer Vorläufersubstanz ("Prodrug") gebildet wird.  Growth regulation of plants also includes the case where the active ingredient of general formula (I) or its salt is formed from a precursor substance ("prodrug") only after plant, plant or soil application.

Gegenstand der Erfindung ist auch die Verwendung einer oder mehrerer Verbindungen der allgemeinen Formel (I) oder deren Salzen bzw. eines erfindungsgemäßen Mittels (wie nachstehend definiert) (in einem Verfahren) zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass man eine wirksame Menge einer oder mehreren Verbindungen der allgemeinen Formel (I) oder deren Salzen auf die Pflanzen (Schadpflanzen, ggf. zusammen mit den Nutzpflanzen) Pflanzensamen, den Boden, in dem oder auf dem die Pflanzen wachsen, oder die Anbaufläche appliziert.  The invention also provides the use of one or more compounds of the general formula (I) or salts thereof or an agent according to the invention (as defined below) (in a process) for controlling harmful plants or regulating the growth of plants, characterized in that an effective amount of one or more compounds of the general formula (I) or their salts on the plants (harmful plants, optionally together with the crops) plant seeds, the soil in which or on which the plants grow, or applied to the acreage.

Gegenstand der Erfindung ist auch ein herbizides und/oder pflanzenwachstumsregulierendes Mittel, dadurch gekennzeichnet, dass das Mittel (a) eine oder mehrere Verbindungen der allgemeinen Formel (I) und/oder deren Salze enthält wie oben definiert, vorzugsweise in einer der als bevorzugt bzw. besonders bevorzugt gekennzeichneten The invention also provides a herbicidal and / or plant growth-regulating agent, characterized in that the agent (a) contains one or more compounds of the general formula (I) and / or salts thereof as defined above, preferably in one of the preferred or particularly preferably marked

Ausgestaltung, insbesondere eine oder mehrere Verbindungen der Formeln (LI) bis (1.182) und/oder deren Salze, jeweils wie oben definiert, Embodiment, in particular one or more compounds of the formulas (LI) to (1.182) and / or salts thereof, each as defined above,

und and

(b) ein oder mehrere weitere Stoffe ausgewählt aus den Gruppen (i) und/oder (ii): (i) ein oder mehrere weitere agrochemisch wirksame Stoffe, vorzugsweise ausgewählt aus der Gruppe bestehend aus Insektiziden, Akariziden, Nematiziden, weiteren Herbiziden (d.h. solche, die nicht der oben definierten allgemeinen Formel (I) entsprechen), Fungiziden, Safenern, Düngemitteln und/oder weiteren Wachstumsregulatoren, (b) one or more further substances selected from groups (i) and / or (ii): (i) one or more further agrochemically active substances, preferably selected from the group consisting of insecticides, acaricides, nematicides, further herbicides (ie those which do not correspond to the general formula (I) defined above), fungicides, safeners, fertilizers and / or or other growth regulators,

(ii) ein oder mehrere im Pflanzenschutz übliche Formulierungshilfsmittel. (ii) one or more formulation aids customary in crop protection.

Die weiteren agrochemischen wirksamen Stoffe des Bestandteils (i) eines erfindungsgemäßen Mittels sind dabei vorzugsweise ausgewählt aus der Gruppe der Stoffe, die in "The Pesticide Manual", 16th edition, The British Crop Protection Council und the Royal Soc. of Chemistry, 2012 genannt sind. The other agrochemically active substances of constituent (i) of an agent according to the invention are preferably selected from the group of substances described in "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012 are mentioned.

Ein erfindungsgemäßes herbizides oder pflanzenwachstumsregulierendes Mittel, umfasst vorzugsweise ein, zwei, drei oder mehr im Pflanzenschutz übliche Formulierungshilfsmittel (ii) ausgewählt aus der Gruppe bestehend aus Tensiden, Emulgatoren, Dispergiermitteln, Filmbildnern, Verdickungsmitteln, anorganischen Salzen, Stäubemitteln, bei 25 °C und 1013 mbar festen Trägerstoffen, vorzugsweise adsorptionsfähigen, granulierten Inertmaterialien, Netzmitteln, Antioxidationsmitteln, Stabilisatoren, Puffersubstanzen, Antischaummitteln, Wasser, organischen Lösungsmitteln, vorzugsweise bei 25 °C und 1013 mbar mit Wasser in jedem beliebigen Verhältnis mischbare organische Lösungsmittel. Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können in Form von Spritzpulvern, emulgierbaren Konzentraten, versprühbaren Lösungen, Stäubemitteln oder Granulaten in den üblichen Zubereitungen angewendet werden. Gegenstand der Erfindung sind deshalb auch herbizide und pflanzenwachstumsregulierende Mittel, die Verbindungen der allgemeinen Formel (I) und/oder deren Salze enthalten. A herbicidal or plant growth-regulating agent according to the invention preferably comprises one, two, three or more plant protection formulation auxiliaries (ii) selected from the group consisting of surfactants, emulsifiers, dispersants, film formers, thickeners, inorganic salts, dusts, at 25 ° C and 1013 mbar solid carriers, preferably adsorptive, granulated inert materials, wetting agents, antioxidants, stabilizers, buffer substances, anti-foaming agents, water, organic solvents, preferably at 25 ° C and 1013 mbar with water in any ratio miscible organic solvents. The compounds of the general formula (I) according to the invention can be used in the form of wettable powders, emulsifiable concentrates, sprayable solutions, dusts or granules in the customary formulations. The invention therefore also relates to herbicidal and plant growth-regulating agents which contain compounds of the general formula (I) and / or salts thereof.

Die Verbindungen der allgemeinen Formel (I) und/oder deren Salze können auf verschiedene Art formuliert werden, je nachdem welche biologischen und/oder chemisch-physikalischen Parameter vorgegeben sind. Als Formulierungsmöglichkeiten kommen beispielsweise in Frage: Spritzpulver (WP), wasserlösliche Pulver (SP), wasserlösliche Konzentrate, emulgierbare Konzentrate (EC), Emulsionen (EW), wie Öl-in- Wasser- und Wasser-in-Öl-Emulsionen, versprühbare Lösungen, The compounds of the general formula (I) and / or their salts can be formulated in various ways, depending on which biological and / or chemical-physical parameters are predetermined. Possible formulation options are, for example: wettable powder (WP), water-soluble powders (SP), water-soluble concentrates, emulsifiable concentrates (EC), emulsions (EW), such as oil-in-water and water-in-oil emulsions, sprayable solutions .

Suspensionskonzentrate (SC), Dispersionen auf Öl- oder Wasserbasis, ölmischbare Lösungen,  Suspension concentrates (SC), dispersions based on oil or water, oil-miscible solutions,

Kapselsuspensionen (CS), Stäubemittel (DP), Beizmittel, Granulate für die Streu- und Capsule suspensions (CS), dusts (DP), mordants, granules for the scattering and

Bodenapplikation, Granulate (GR) in Form von Mikro-, Sprüh-, Aufzugs- und Adsorptionsgranulaten, wasserdispergierbare Granulate (WG), wasserlösliche Granulate (SG), ULV-Formulierungen, Soil application, granules (GR) in the form of micro, spray, elevator and adsorption granules, water-dispersible granules (WG), water-soluble granules (SG), ULV formulations,

Mikrokapseln und Wachse. Diese einzelnen Formulierungstypen und die Formulierungshilfsmittel wie Inertmaterialien, Tenside, Lösungsmittel und weitere Zusatzstoffe sind dem Fachmann bekannt, und werden beispielsweise beschrieben in: Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland Books, Caldwell N.J., H.v. Olphen, "Introduction to Clay Colloid Chemistry"; 2nd Ed., J. Wiley & Sons, N.Y.; C. Marsden, "Solvents Guide"; 2nd Ed., Interscience, N.Y. 1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood N.J.; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., N.Y. 1964; Schönfeldt, "Grenzflächenaktive Microcapsules and waxes. These individual types of formulation and formulation aids such as inert materials, surfactants, solvents and other additives are known to those skilled in the art and are described, for example, in Watkins, Handbook of Insecticides Dust Diluents and Carriers, 2nd Ed., Darland Books, Caldwell NJ, Hv Olphen , "Introduction to Clay Colloid Chemistry"; 2nd Ed., J. Wiley & Sons, NY; C. Marsden, "Solvents Guide"; 2nd Ed., Interscience, NY 1963; McCutcheon's "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood NJ; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., NY 1964; Schönfeldt, "Grenzflächenaktive

Äthylenoxidaddukte", Wiss. Verlagsgesellschaft, Stuttgart 1976; Winnacker-Küchler, "Chemische Technologie", Band 7, C. Hanser Verlag München, 4. Aufl. 1986. Äthylenoxidaddukte ", Wiss. Verlagsgesellschaft, Stuttgart 1976; Winnacker-Küchler," Chemical Technology ", Volume 7, C. Hanser Verlag Munich, 4th ed., 1986.

Spritzpulver sind in Wasser gleichmäßig dispergierbare Präparate, die neben dem Wirkstoff außer einem Verdünnungs- oder Inertstoff noch Tenside ionischer und/oder nichtionischer Art (Netzmittel, Injectable powders are preparations which are uniformly dispersible in water and, in addition to the active substance, also contain surfactants of an ionic and / or nonionic type (wetting agent,

Dispergiermittel), z.B. polyoxyethylierte Alkylphenole, polyoxethylierte Fettalkohole, polyoxethylierte Fettamine, Fettalkoholpolyglykolethersulfate, Alkansulfonate, Alkylbenzolsulfonate, ligninsulfonsaures Natrium, 2,2'-dinaphthylmethan-6,6'-disulfonsaures Natrium, dibutylnaphthalin-sulfonsaures Natrium oder auch oleoylmethyltaurinsaures Natrium enthalten. Zur Herstellung der Spritzpulver werden die herbiziden Wirkstoffe beispielsweise in üblichen Apparaturen wie Hammermühlen, Gebläsemühlen und Luftstrahlmühlen feingemahlen und gleichzeitig oder anschließend mit den Formulierungshilfsmitteln vermischt. Dispersant), e.g. polyoxyethylated alkylphenols, polyoxethylated fatty alcohols, polyoxethylated fatty amines, fatty alcohol polyglycol ether sulfates, alkanesulfonates, alkylbenzenesulfonates, sodium lignosulfonate, sodium 2,2'-dinaphthylmethane-6,6'-disulfonate, sodium dibutylnaphthalene-sulfonate, or sodium oleoylmethyltaurine. To prepare the wettable powders, the herbicidal active compounds are finely ground, for example, in customary apparatus such as hammer mills, blower mills and air-jet mills and mixed simultaneously or subsequently with the formulation auxiliaries.

Emulgierbare Konzentrate werden durch Auflösen des Wirkstoffes in einem organischen Lösungsmittel z.B. Butanol, Cyclohexanon, Dimethylformamid, Xylol oder auch höhersiedenden Aromaten oder Kohlenwasserstoffen oder Mischungen der organischen Lösungsmittel unter Zusatz von einem oder mehreren Tensiden ionischer und/oder nichtionischer Art (Emulgatoren) hergestellt. Als Emulgatoren können beispielsweise verwendet werden: Alkylarylsulfonsaure Calcium-Salze wie Emulsifiable concentrates are prepared by dissolving the active ingredient in an organic solvent, e.g. Butanol, cyclohexanone, dimethylformamide, xylene or higher-boiling aromatics or hydrocarbons or mixtures of organic solvents with the addition of one or more surfactants of ionic and / or nonionic type (emulsifiers). As emulsifiers can be used for example: Alkylarylsulfonsaure calcium salts such as

Ca-dodecylbenzolsulfonat oder nichtionische Emulgatoren wie Fettsäurepolyglykolester,  Ca-dodecylbenzenesulfonate or nonionic emulsifiers such as fatty acid polyglycol ester,

Alkylarylpolyglykolether, Fettalkoholpolyglykolether, Propylenoxid-Ethylenoxid- Kondensationsprodukte, Alkylpolyether, Sorbitanester wie z.B. Sorbitanfettsäureester oder Alkylaryl polyglycol ethers, fatty alcohol polyglycol ethers, propylene oxide-ethylene oxide condensation products, alkyl polyethers, sorbitan esters such as e.g. Sorbitan fatty acid esters or

Polyoxethylensorbitanester wie z.B. Polyoxyethylensorbitanfettsäureester. Polyoxethylenesorbitanester such. Polyoxyethylene.

Stäubemittel erhält man durch Vermählen des Wirkstoffes mit fein verteilten festen Stoffen, z.B. Dusts are obtained by milling the active ingredient with finely divided solids, e.g.

Talkum, natürlichen Tonen, wie Kaolin, Bentonit und Pyrophyllit, oder Diatomeenerde. Talc, natural clays such as kaolin, bentonite and pyrophyllite, or diatomaceous earth.

Suspensionskonzentrate können auf Wasser- oder Ölbasis sein. Sie können beispielsweise durch Naß-Vermahlung mittels handelsüblicher Perlmühlen und gegebenenfalls Zusatz von Tensiden, wie sie z.B. oben bei den anderen Formulierungstypen bereits aufgeführt sind, hergestellt werden. Emulsionen, z.B. Öl-in- Wasser-Emulsionen (EW), lassen sich beispielsweise mittels Rührern, Suspension concentrates may be water or oil based. They can be prepared, for example, by wet grinding by means of commercially available bead mills and, if appropriate, addition of surfactants, as already listed above, for example, in the other formulation types. Emulsions, for example oil-in-water emulsions (EW), can be prepared, for example, by means of stirrers,

Kolloidmühlen und/oder statischen Mischern unter Verwendung von wäßrigen organischen Colloidal mills and / or static mixers using aqueous organic

Lösungsmitteln und gegebenenfalls Tensiden, wie sie z.B. oben bei den anderen Formulierungstypen bereits aufgeführt sind, herstellen. Solvents and optionally surfactants, such as e.g. listed above for the other formulation types.

Granulate können entweder durch Verdüsen des Wirkstoffes auf adsorptionsfähiges, granuliertes Inertmaterial hergestellt werden oder durch Aufbringen von Wirkstoffkonzentraten mittels Klebemitteln, z.B. Polyvinylalkohol, polyacrylsaurem Natrium oder auch Mineralölen, auf die Oberfläche von Trägerstoffen wie Sand, Kaolinite oder von granuliertem Inertmaterial. Auch können geeignete Granules can either be prepared by atomizing the active ingredient on adsorptive, granulated inert material or by applying active substance concentrates by means of adhesives, e.g. Polyvinyl alcohol, polyacrylic acid sodium or mineral oils, on the surface of carriers such as sand, kaolinites or granulated inert material. Also suitable

Wirkstoffe in der für die Herstellung von Düngemittelgranulaten üblichen Weise - gewünschtenfalls in Mischung mit Düngemitteln - granuliert werden. Active ingredients in the usual manner for the production of fertilizer granules - if desired, mixed with fertilizers - granulated.

Wasserdispergierbare Granulate werden in der Regel nach den üblichen Verfahren wie Sprühtrocknung, Wirbelbett-Granulierung, Teller-Granulierung, Mischung mit Hochgeschwindigkeitsmischern und Extrusion ohne festes Inertmaterial hergestellt. Water-dispersible granules are generally prepared by the usual methods such as spray drying, fluidized bed granulation, plate granulation, mixing with high-speed mixers and extrusion without solid inert material.

Zur Herstellung von Teller-, Fließbett-, Extruder- und Sprühgranulaten siehe z.B. Verfahren in "Spray- Drying Handbook" 3rd ed. 1979, G. Goodwin Ltd., London; J.E. Browning, "Agglomeration", Chemical and Engineering 1967, Seiten 147 ff; "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York 1973, S. 8-57. For the preparation of plate, fluid bed, extruder and spray granules, see e.g. Method in "Spray-Drying Handbook" 3rd ed. 1979, G. Goodwin Ltd., London; J.E. Browning, "Agglomeration", Chemical and Engineering 1967, pages 147 ff; Perry's Chemical Engineer's Handbook, 5th Ed., McGraw-Hill, New York 1973, pp. 8-57.

Für weitere Einzelheiten zur Formulierung von Pflanzenschutzmitteln siehe z.B. G.C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, Seiten 81-96 und J.D. Freyer, S.A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, Seiten 101-103. For further details on the formulation of crop protection agents see, e.g. G.C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96 and J.D. Freyer, S.A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

Die agrochemischen Zubereitungen, vorzugsweise herbizide oder pflanzenwachstumsregulierende Mittel der vorliegenden Erfindung enthalten vorzugsweise eine Gesamtmenge von 0,1 bis 99 Gew.-%, bevorzugt 0,5 bis 95 Gew.- %, weiter bevorzugt 1 bis 90 Gew.- %, insbesondere bevorzugt 2 bis 80 Gew.-%, an Wirkstoffen der allgemeinen Formel (I) und deren Salzen. The agrochemical preparations, preferably herbicidal or plant growth-regulating agents of the present invention, preferably contain a total amount of from 0.1 to 99% by weight, preferably 0.5 to 95% by weight, more preferably 1 to 90% by weight, more preferably 2 to 80 wt .-%, of active compounds of the general formula (I) and their salts.

In Spritzpulvern beträgt die Wirkstoffkonzentration z.B. etwa 10 bis 90 Gew.-%, der Rest zu 100 Gew.-% besteht aus üblichen Formulierungsbestandteilen. Bei emulgierbaren Konzentraten kann die Wirkstoffkonzentration etwa 1 bis 90, vorzugsweise 5 bis 80 Gew.-% betragen. Staubförmige In wettable powders, the drug concentration is e.g. about 10 to 90 wt .-%, the balance to 100 wt .-% consists of conventional formulation ingredients. For emulsifiable concentrates, the active ingredient concentration may be about 1 to 90, preferably 5 to 80 wt .-%. Powdery

Formulierungen enthalten 1 bis 30 Gew.-% Wirkstoff, vorzugsweise meistens 5 bis 20 Gew.-% anFormulations contain 1 to 30 wt .-% of active ingredient, preferably usually 5 to 20 wt .-% of

Wirkstoff, versprühbare Lösungen enthalten etwa 0,05 bis 80, vorzugsweise 2 bis 50 Gew.-% Wirkstoff. Bei wasserdispergierbaren Granulaten hängt der Wirkstoffgehalt zum Teil davon ab, ob die wirksame Verbindung flüssig oder fest vorliegt und welche Granulierhilfsmittel, Füllstoffe usw. verwendet werden. Bei den in Wasser dispergierbaren Granulaten liegt der Gehalt an Wirkstoff beispielsweise zwischen 1 und 95 Gew.-%, vorzugsweise zwischen 10 und 80 Gew.-%. Daneben enthalten die genannten Wirkstofformulierungen gegebenenfalls die jeweils üblichen Haft-, Netz-, Dispergier-, Emulgier-, Penetrations-, Konservierungs-, Frostschutz- und Lösungsmittel, Füll-, Träger- und Farbstoffe, Entschäumer, Verdunstungshemmer und den pH- Wert und die Viskosität beeinflussende Mittel. Beispiele für Formulierungshilfsmittel sind unter anderem in "Chemistry and Technology of Agrochemical Formulations", ed. D. A. Knowles, Kluwer Academic Publishers (1998) beschrieben. Active ingredient, sprayable solutions contain about 0.05 to 80, preferably 2 to 50 wt .-% of active ingredient. In the case of water-dispersible granules, the active ingredient content depends, in part, on whether the active ingredient Liquid or solid compound is present and which granulation aids, fillers, etc. are used. In the case of the water-dispersible granules, the content of active ingredient is, for example, between 1 and 95% by weight, preferably between 10 and 80% by weight. In addition, the active substance formulations mentioned optionally contain the customary adhesion, wetting, dispersing, emulsifying, penetrating, preserving, antifreezing and solvent, fillers, carriers and dyes, antifoams, evaporation inhibitors and the pH and the Viscosity-influencing agent. Examples of formulation auxiliaries are described, inter alia, in "Chemistry and Technology of Agrochemical Formulations", ed. DA Knowles, Kluwer Academic Publishers (1998).

Die Verbindungen der allgemeinen Formel (I) oder deren Salze können als solche oder in Form ihrer Zubereitungen (Formulierungen) mit anderen pestizid wirksamen Stoffen, wie z.B. Insektiziden, Akariziden, Nematiziden, Herbiziden, Fungiziden, Safenern, Düngemitteln und/oder The compounds of general formula (I) or their salts may be used as such or in the form of their formulations (formulations) with other pesticidally active substances, e.g. Insecticides, acaricides, nematicides, herbicides, fungicides, safeners, fertilizers and / or

Wachstumsregulatoren kombiniert eingesetzt werden, z.B. als Fertigformulierung oder als Growth regulators can be used in combination, e.g. as finished formulation or as

Tankmischungen. Die Kombinationsformulierungen können dabei auf Basis der obengenannten Formulierungen hergestellt werden, wobei die physikalischen Eigenschaften und Stabilitäten der zu kombinierenden Wirkstoffe zu berücksichtigen sind. Als Kombinationspartner für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in Mischungsformulierungen oder im Tank-Mix sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise Acetolactat-Synthase, Acetyl-CoA-Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat-Synthase, Glutamin-Synthetase, p-Hydroxyphenylpyruvat- Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II, Protoporphyrinogen-Oxidase beruhen, einsetzbar, wie sie z.B. in Weed Research 26 (1986) 441-445 oder "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012 und der dort zitierten Literatur beschrieben sind.  Tank mixes. The combination formulations can be prepared on the basis of the above-mentioned formulations, taking into account the physical properties and stabilities of the active ingredients to be combined. Examples of combination partners for the compounds of general formula (I) according to the invention in mixture formulations or in tank mix are known active compounds which are based on inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvylshikimate-3-phosphate Synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoene desaturase, photosystem I, photosystem II, protoporphyrinogen oxidase are based, can be used, such as in Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012 and the literature cited therein.

Von besonderem Interesse ist die selektive Bekämpfung von Schadpflanzen in Kulturen von Nutz- und Zierpflanzen. Obgleich die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) bereits in vielen Kulturen sehr gute bis ausreichende Selektivität aufweisen, können prinzipiell in einigen Kulturen und vor allem auch im Falle von Mischungen mit anderen Herbiziden, die weniger selektiv sind, Phytotoxizitäten an den Kulturpflanzen auftreten. Diesbezüglich sind Kombinationen Of particular interest is the selective control of harmful plants in crops of commercial and ornamental plants. Although the compounds of the general formula (I) according to the invention already have very good to sufficient selectivity in many cultures, phytotoxicities on the crop plants can in principle occur in some crops and, above all, in the case of mixtures with other herbicides which are less selective. In this regard, combinations are

erfindungsgemäßer Verbindungen (I) von besonderem Interesse, welche die Verbindungen der allgemeinen Formel (I) bzw. deren Kombinationen mit anderen Herbiziden oder Pestiziden undCompounds of the invention (I) of particular interest which contain the compounds of the general formula (I) or their combinations with other herbicides or pesticides and

Safenern enthalten. Die Safener, welche in einem antidotisch wirksamen Gehalt eingesetzt werden, reduzieren die phytotoxischen Nebenwirkungen der eingesetzten Herbizide/Pestizide, z.B. in wirtschaftlich bedeutenden Kulturen wie Getreide (Weizen, Gerste, Roggen, Mais, Reis, Hirse), Zuckerrübe, Zuckerrohr, Raps, Baumwolle und Soja, vorzugsweise Getreide. Contain safeners. The safeners, which are used in an antidote effective content, reduce the phytotoxic side effects of the herbicides / pesticides used, eg in economically important crops such as cereals (wheat, barley, rye, corn, rice, millet), sugar beet, sugar cane, oilseed rape, cotton and soybeans, preferably cereals.

Die Gewichtsverhältnisse von Herbizid(mischung) zu Safener hängt im Allgemeinen von der The weight ratios of herbicide (mixture) to safener generally depends on the

Aufwandmenge an Herbizid und der Wirksamkeit des jeweiligen Safeners ab und kann innerhalb weiter Grenzen variieren, beispielsweise im Bereich von 200: 1 bis 1 :200, vorzugsweise 100: 1 bis 1 : 100, insbesondere 20:1 bis 1 :20. Die Safener können analog den Verbindungen der allgemeinen Formel (I) oder deren Mischungen mit weiteren Herbiziden/Pestiziden formuliert werden und als Application rate of herbicide and the effectiveness of each safener and may vary within wide limits, for example in the range of 200: 1 to 1: 200, preferably 100: 1 to 1: 100, especially 20: 1 to 1: 20. The safeners can be formulated analogously to the compounds of the general formula (I) or mixtures thereof with further herbicides / pesticides and as

Fertigformulierung oder Tankmischung mit den Herbiziden bereitgestellt und angewendet werden. Ready-made formulation or tank mix with the herbicides are provided and used.

Zur Anwendung werden die in handelsüblicher Form vorliegenden Herbizid- oder Herbizid- Safener- Formulierungen gegebenenfalls in üblicher Weise verdünnt z.B. bei Spritzpulvern, emulgierbaren Konzentraten, Dispersionen und wasserdispergierbaren Granulaten mittels Wasser. Staubförmige Zubereitungen, Boden- bzw. Streugranulate sowie versprühbare Lösungen werden vor der Anwendung üblicherweise nicht mehr mit weiteren inerten Stoffen verdünnt. For use, the herbicidal or herbicidal safener formulations present in commercial form are optionally diluted in a customary manner, e.g. for wettable powders, emulsifiable concentrates, dispersions and water-dispersible granules by means of water. Dust-like preparations, ground or scattered granules and sprayable solutions are usually no longer diluted with other inert substances before use.

Äußere Bedingungen wie Temperatur, Feuchtigkeit etc. beeinflussen zu einem gewissen Teil die Aufwandmenge der Verbindungen der allgemeinen Formel (I) und/oder deren Salze. Die External conditions such as temperature, humidity, etc. influence to a certain extent the application rate of the compounds of general formula (I) and / or their salts. The

Aufwandmenge kann dabei innerhalb weiter Grenzen variieren. Für die Anwendung als Herbizid zur Bekämpfung von Schadpflanzen liegt die Gesamtmenge an Verbindungen der allgemeinen Formel (I) und deren Salze vorzugsweise im Bereich von 0,001 bis 10,0 kg/ha, bevorzugt im Bereich von 0,005 bis 5 kg/ha, weiter bevorzugt im Bereich von 0,01 bis 1,5 kg/ha, insbesondere bevorzugt im Bereich von 0,05 bis 1 kg/ha. Dies gilt sowohl für die Anwendung im Vorauflauf oder im Nachauflauf. Bei der Anwendung von Verbindungen der allgemeinen Formel (I) und/oder deren Salzen als Application rate can vary within wide limits. For use as a herbicide for controlling harmful plants, the total amount of compounds of general formula (I) and their salts is preferably in the range of 0.001 to 10.0 kg / ha, preferably in the range of 0.005 to 5 kg / ha, more preferably in Range of 0.01 to 1.5 kg / ha, particularly preferably in the range of 0.05 to 1 kg / ha. This applies both to pre-emergence or post-emergence applications. In the application of compounds of general formula (I) and / or their salts as

Pflanzenwachstumsregulator, beispielsweise als Halmverkürzer bei Kulturpflanzen, wie sie oben genannt worden sind, vorzugsweise bei Getreidepflanzen wie Weizen, Gerste, Roggen, Triticale, Hirse, Reis oder Mais, liegt die Gesamt- Aufwandmenge vorzugsweise im Bereich von 0,001 bis 2 kg/ha, vorzugsweise im Bereich von 0,005 bis 1 kg/ha, insbesondere im Bereich von 10 bis 500 g/ha, ganz besonders bevorzugt im Bereich von 20 bis 250 g/ha. Dies gilt sowohl für die Anwendung im  Plant growth regulator, for example as Halmverkürzer in crops, as mentioned above, preferably in cereal plants such as wheat, barley, rye, triticale, millet, rice or corn, the total application rate is preferably in the range of 0.001 to 2 kg / ha, preferably in the range of 0.005 to 1 kg / ha, in particular in the range of 10 to 500 g / ha, most preferably in the range of 20 to 250 g / ha. This applies to both the application in the

Vorauflauf oder im Nachauflauf. Pre-emergence or postemergence.

Die Applikation als Halmverkürzer kann in verschiedenen Stadien des Wachstums der Pflanzen erfolgen. Bevorzugt ist beispielsweise die Anwendung nach der Bestückung am Beginn des The application as Halmverkürzer can be done in various stages of growth of the plants. For example, the application is preferred after placement at the beginning of

Längenwachstums . Alternativ kommt bei der Anwendung als Pflanzenwachstumsregulator auch die Behandlung des Saatguts in Frage, welche die unterschiedlichen Saatgutbeiz- und Beschichtungstechniken einschließt. Die Aufwandmenge hängt dabei von den einzelnen Techniken ab und kann in Vorversuchen ermittelt werden. Length growth. Alternatively, when used as a plant growth regulator, seed treatment may be considered, including the different seed dressing and coating techniques. The application rate depends on the individual techniques and can be determined in preliminary tests.

Als Kombinationspartner für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in erfindungsgemäßen Mitteln (z.B. Mischungsformulierungen oder im Tank-Mix) sind beispielsweise bekannte Wirkstoffe, die auf einer Inhibition von beispielsweise Acetolactat-Synthase, Acetyl-CoA- Carboxylase, Cellulose-Synthase, Enolpyruvylshikimat-3-phosphat-Synthase, Glutamin-Synthetase, p- Hydroxyphenylpyruvat-Dioxygenase, Phytoendesaturase, Photosystem I, Photosystem II oder As combination partners for the compounds of the general formula (I) according to the invention (eg mixture formulations or in tank mix), for example, known active compounds which are based on an inhibition of, for example, acetolactate synthase, acetyl-CoA carboxylase, cellulose synthase, enolpyruvyl shikimate 3-phosphate synthase, glutamine synthetase, p-hydroxyphenylpyruvate dioxygenase, phytoene desaturase, photosystem I, photosystem II or

Protoporphyrinogen-Oxidase beruhen, einsetzbar, wie sie z.B. aus Weed Research 26 (1986) 441-445 oder "The Pesticide Manual", 16th edition, The British Crop Protection Council und the Royal Soc. of Chemistry, 2012 und dort zitierter Literatur beschrieben sind. Nachfolgend werden beispielhaft bekannte Herbizide oder Pflanzenwachstumsregulatoren genannt, die mit den erfindungsgemäßen Verbindungen kombiniert werden können, wobei diese Wirkstoffe entweder mit ihrem "common name" in der englischsprachigen Variante gemäß International Organization for Standardization (ISO) oder mit dem chemischen Namen bzw. mit der Codenummer bezeichnet sind. Dabei sind stets sämtliche  Protoporphyrinogen oxidase, can be used, as e.g. from Weed Research 26 (1986) 441-445 or "The Pesticide Manual", 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2012 and cited therein. The following are examples of known herbicides or plant growth regulators, which can be combined with the compounds of the invention, these agents either with their "common name" in the English version according to International Organization for Standardization (ISO) or with the chemical name or with the code number are designated. There are always all

Anwendungsformen wie beispielsweise Säuren, Salze, Ester sowie auch alle isomeren Formen wie Stereoisomere und optische Isomere umfaßt, auch wenn diese nicht explizit erwähnt sind. Use forms such as acids, salts, esters as well as all isomeric forms such as stereoisomers and optical isomers, even if they are not explicitly mentioned.

Beispiele für solche herbiziden Mischungspartner sind: Examples of such herbicidal mixture partners are:

Acetochlor, acifluorfen, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim- sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, 4-amino-3-chloro-6-(4-chloro-2-fluoro-3- methylphenyl)-5-fluoropyridine-2-carboxylic acid, aminocyclopyrachlor, aminocyclopyrachlor- potassium, aminocyclopyrachlor-methyl, aminopyralid, amitrole, ammoniumsulfamate, anilofos, asulam, atrazine, azafenidin, azimsulfuron, beflubutamid, benazolin, benazolin-ethyl, benfluralin, benfuresate, bensulfuron, bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap, bicyclopyron, bifenox, bilanafos, bilanafos-sodium, bispyribac, bispyribac-sodium, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil-butyrate, -potassium, -heptanoate und -octanoate, busoxinone, butachlor, butafenacil, butamifos, butenachlor, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone, carfentrazone-ethyl, chloramben, chlorbromuron, chlorfenac, chlorfenac- sodium, chlorfenprop, chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlorophthalim, chlorotoluron, chlorthal-dimethyl, chlorsulfuron, cinidon, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clethodim, clodinafop, clodinafop-propargyl, clomazone, clomeprop, clopyralid, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop, cyhalofop-butyl, cyprazine, 2,4-D, 2,4-D-butotyl, -butyl, - dimethylammonium, -diolamin, -ethyl, 2-ethylhexyl, -isobutyl, -isooctyl, -isopropylammonium, - potassium, -triisopropanolammonium und -trolamine, 2,4-DB, 2,4-DB-butyl, -dimethylammonium, isooctyl, -potassium und -sodium, daimuron (dymron), dalapon, dazomet, n-decanol, desmedipham, detosyl-pyrazolate (DTP), dicamba, dichlobenil, 2-(2,4-dichlorobenzyl)-4,4-dimethyl-l,2-oxazolidin-3- one, 2-(2,5-dichlorobenzyl)-4,4-dimethyl-l,2-oxazolidin-3-one, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, diclofop-P-methyl, diclosulam, difenzoquat, diflufenican, diflufenzopyr, diflufenzopyr- sodium, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimetrasulfuron, dinitramine, dinoterb, diphenamid, diquat, diquat-dibromid, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxyfen- ethyl, ethoxysulfuron, etobenzanid, F-9600, F-5231, i.e. N-[2- Chlor-4-fluor-5-[4-(3-fluorpropyl)-4,5-dihydro-5-oxo-lH-tetrazol-l-yl]-phenyl]-ethansulfonamid, F- 7967, i.e. 3-[7-Chlor-5-fluor-2-(trifluormethyl)-lH-benzimidazol-4-yl]-l-methyl-6- (trifluormethyl)pyrimidin-2,4(lH,3H)-dion, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P- ethyl, fenoxasulfone, fenquinotrione, fentrazamide, flamprop, flamprop-M-isopropyl, flamprop-M- methyl, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, Acetochlor, acifluorfen, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, 4-amino-3-chloro-6- (4-chloro-2-fluoro-3-methylphenyl ) -5-fluoropyridines-2-carboxylic acid, aminocyclopyrachlor, aminocyclopyrachloro- potassium, aminocyclopyrachloromethyl, aminopyralid, amitrole, ammonium sulfamates, anilofos, asulam, atrazine, azafenidin, azimsulfuron, beflubutamid, benazolin, benazolin-ethyl, benfluralin, benfuresate, bensulfuron , bensulphon-methyl, bensulide, bentazone, benzobicyclone, benzofenap, bicyclopyrone, bifenox, bilanafos, bilanafos-sodium, bispyribac, bispyribac-sodium, bromacil, bromobutide, bromofenoxime, bromoxynil, bromoxynil-butyrate, -potassium, -heptanoates and -octanoates, busoxinone, butachlor, butafenacil, butamifos, butenachlor, butraline, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone, carfentrazone-ethyl, chloramben, chlorobromuron, chlorfenac, chlorfenac-sodium, chlorfenprop, ch lorflurenol, chlorofurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlorophthalim, chlorotoluron, chlororthal-dimethyl, chlorosulfuron, cinidon, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clethodim, clodinafop, clodinafop-propargyl, clomazone, clomeprop, clopyralid, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop, cyhalofop-butyl, cyprazine, 2,4-D, 2,4-D-butotyl, -butyl, - dimethylammonium, -diolamine , -ethyl, 2-ethylhexyl, -isobutyl, -isooctyl, -isopropylammonium, - potassium, triisopropanolammonium and -trolamines, 2,4-DB, 2,4-DB-butyl, -dimethylammonium, isooctyl, -potassium and -sodium, daimuron (dymron), dalapon, dazomet, n-decanol, desmedipham, detosyl- pyrazolates (DTP), dicamba, dichlobenil, 2- (2,4-dichlorobenzyl) -4,4-dimethyl-1,2-oxazolidin-3-one, 2- (2,5-dichlorobenzyl) -4,4-dimethyl -l, 2-oxazolidin-3-one, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, diclofop-P-methyl, diclosulam, difenzoquat, diflufenican, diflufenzopyr, diflufenzopyr-sodium, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid , dimethenamid-P, dimetrasulfuron, dinitramine, dinoterb, diphenamid, diquat, diquat-dibromide, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethiozine, ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron , etobenzanide, F-9600, F-5231, ie N- [2-chloro-4-fluoro-5- [4- (3-fluoropropyl) -4,5-dihydro-5-oxo-1H-tetrazole] yl] -phenyl] -ethanesulfonamide, F-7967, ie 3- [7-chloro-5- fluoro-2- (trifluoromethyl) -1H-benzimidazol-4-yl] -1-methyl-6- (trifluoromethyl) pyrimidine-2,4 (1H, 3H) -dione, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop P-ethyl, fenoxasulfones, fenquinotrione, fentrazamide, flamprop, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-p-butyl,

flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac, flumiclorac-pentyl, flumioxazin, fluometuron, flurenol, flurenol-butyl, - dimethylammonium und -methyl, fluoroglycofen, fluoroglycofen-ethyl, flupropanate, flupyrsulfuron, flupyrsulfuron-methyl-sodium, fluridone, flurochloridone, fluroxypyr, fluroxypyr-meptyl, flurtamone, fluthiacet, fluthiacet-methyl, fomesafen, fomesafen-sodium, foramsulfuron, fosamine, glufosinate, glufosinate-ammonium, glufosinate-P-sodium, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-ammonium, -isopropylammonium, -diammonium, -dimethylammonium, - potassium, -sodium und -trimesium, H-9201, i.e. 0-(2,4-Dimethyl-6-nitrophenyl)-0-ethyl- isopropylphosphoramidothioat, halauxifen, halauxifen-methyl, halosafen, halosulfuron, halosulfuron- methyl, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, hexazinone, HW-02, i.e. l-(Dimethoxyphosphoryl)-ethyl-(2,4- dichlorphenoxy)acetat, imazamethabenz, Imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin- ammonium, imazethapyr, imazethapyr-immonium, imazosulfuron, indanofan, indaziflam, iodosulfuron, iodosulfuron-methyl-sodium, ioxynil, ioxynil-octanoate, -potassium und sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, karbutilate, KUH-043, i.e. 3-({[5-(Difluormethyl)-l - methyl-3-(trifluormethyl)- 1 H-pyrazol-4-yl]methyl} sulfonyl)-5,5-dimethyl-4,5-dihydro- 1 ,2-oxazol, ketospiradox, lactofen, lenacil, linuron, MCPA, MCPA-butotyl, -dimethylammonium, -2-ethylhexyl, - isopropylammonium, -potassium und -sodium, MCPB, MCPB-methyl, -ethyl und -sodium, mecoprop, mecoprop-sodium, und -butotyl, mecoprop-P, mecoprop-P-butotyl, -dimethylammonium, -2-ethylhexyl und -potassium, mefenacet, mefluidide, mesosulfuron, mesosulfuron-methyl, mesotrione, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac, flumiclorac-pentyl, flumioxazine, fluometuron, flurenol, flurenol-butyl, - dimethylammonium and -methyl, fluoroglycofen, fluoroglycofen-ethyl, flupropanate, flupyrsulfuron, flupyrsulfuron-methyl-sodium, fluridone, flurochloridone, fluroxypyr, fluroxypyr-meptyl, flurtamone, fluthiacet, fluthiacet-methyl, fomesafen, fomesafen-sodium, foramsulfuron, fosamine, glufosinate, glufosinate-ammonium, glufosinate-p-sodium, glufosinate- P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-ammonium, -isopropylammonium, -diammonium, -dimethylammonium, -potassium, -sodium and -trimesium, H-9201, ie 0- (2,4-dimethyl-6-nitrophenyl) -0-ethyl-isopropylphosphoramidothioate, halo-cy, halauxifen-methyl, halosafen, halosulfuron, halosulfuron-methyl, haloxyfop, haloxyfop-P, haloxyfopethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, hexazinone, HW-02, ie 1- (dimethoxyphosphoryl) ethyl- (2,4-dichlorophenoxy) acetate, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapicammonium, imazapyr, imazapyrisopropylammonium, imazaquin, imazaquinammonium, imazethapyr, imazethapyr -immonium, imazosulfuron, indanofan, indaziflam, iodosulfuron, iodosulfuron-methyl-sodium, ioxynil, ioxynil-octanoate, -potassium and sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, karbutilate, KUH-043, ie 3 - ({[5- (Difluoromethyl) -1-methyl-3- (trifluoromethyl) -1 H -pyrazol-4-yl] methyl} sulfonyl) -5,5-dimethyl-4,5-dihydro-1,2 -oxazole, ketospiradox, lactofen, lenacil, linuron, MCPA, MCPA-butotyl, -dimethylammonium, -2-ethylhexyl, - isopropylammonium, -potassium and -sodium, MCPB, MCPB-methyl, -ethyl and -sodium, mecoprop, mecoprop- sodium and -butotyl, mecoprop-P, mecoprop-P-butotyl, -dimethylammonium, -2-ethylhexyl and -potassium, mefenacet, mefluidide, mesosulfuron, mesosulfuron-methyl, mesotrione,

methabenzthiazuron, metam, metamifop, metamitron, metazachlor, metazosulfuron, methabenzothiazuron, metam, metamifop, metamitron, metazachlor, metazosulfuron,

methabenzthiazuron, methiopyrsulfuron, methiozolin, methyl isothiocyanate, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, metsulfuron-methyl, molmat, monolmuron, monosulfüron, monosulfüron-ester, MT-5950, i.e. N-[3-chlor-4-(l-methylethyl)- phenyl]-2-methylpentanamid, NGGC-011, napropamide, NC-310, i.e. 4-(2,4-Dichlorbenzoyl)-l-methyl- 5-benzyloxypyrazol, neburon, nicosulfuron, nonanoic acid (Pelargonsäure), norflurazon, oleic acid (fatty acids), orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefon, oxyfluorfen, paraquat, paraquat dichloride, pebulate, pendimethalin, penoxsulam, pentachlorphenol, pentoxazone, pethoxamid, petroleum oils, phenmedipham, picloram, picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate (pyrazolate), pyrazosulfuron, pyrazosulfuron- ethyl, pyrazoxyfen, pyribambenz, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, SL-261, sulcotrion, sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosulfuron, , SYN-523, SYP-249, i.e. l-Ethoxy-3-methyl-l-oxobut-3-en-2-yl- 5-[2-chlor-4-(trifluormethyl)phenoxy]-2-nitrobenzoat, SYP-300, i.e. l-[7-Fluor-3-oxo-4-(prop-2-in-l- yl)-3,4-dihydro-2H-l,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidin-4,5-dion, 2,3,6-TBA, TCA (Trifluoressigsäure), TCA-sodium, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbumeton, terbuthylazin, terbutryn, thenylchlor, thiazopyr, thiencarbazone, thiencarbazone- methyl, thifensulfuron, thifensulfuron-methyl, thiobencarb, tiafenacil, tolpyralate, topramezone, tralkoxydim, triafamone, tri-allate, triasulfuron, triaziflam, tribenuron, tribenuron-methyl, triclopyr, trietazine, trifloxysulfuron, trifloxysulfuron-sodium, trifludimoxazin, trifluralin, triflusulfuron, triflusulfuron-methyl, tritosulfuron, urea sulfate, vernolate, XDE-848, ZJ-0862, i.e. 3,4-Dichlor-N- {2- [(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}anilin, sowie die folgenden Verbindungen: methabenzthiazuron, methiopyrsulfuron, methiozoline, methyl isothiocyanate, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, metsulfuron-methyl, molmat, monolmuron, monosulfuron, monosulfuron ester, MT-5950, ie N- [3-chloro-4- (1-methylethyl) -phenyl] 2-methylpentanamide, NGGC-011, napropamide, NC-310, ie 4- (2,4-dichlorobenzoyl) -l-methyl-5-benzyloxypyrazole, neburon, nicosulfuron, nonanoic acid (pelargonic acid), norflurazon, oleic acid (fatty acids), orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefon, oxyfluorfen, paraquat, paraquat dichloride, pebulate, pendimethalin, penoxsulam, pentachlorophenol, pentoxazone, pethoxamide, petroleum oils, phenmedipham, picloram, picolinafen, pinoxaden, piperophos, pretilachlor , primisulfuron, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate (pyrazolate), pyrazosulfuron, pyrazosulfuron ethyl, pyrazoxyfen, pyribambenz, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyramidal, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone , pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, SL-261, sulcotrione, sulfentrazone , sulfometuron, sulfometuron-methyl, sulfosulfuron,, SYN-523, SYP-249, ie, 1-ethoxy-3-methyl-1-oxobut-3-en-2-yl-5- [2-chloro-4- (trifluoromethyl ) phenoxy] -2-nitrobenzoate, SYP-300, ie 1- [7-fluoro-3-oxo-4- (prop-2-yn-1-yl) -3,4-dihydro-2H-l, 4- benzoxazin-6-yl] -3-propyl-2-thioxoimidazolidine-4,5-dione, 2,3,6-TBA, TCA (trifluoroacetic acid), TCA-sodium, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbumeton, terbuthylazine, terbutryn, th enylchloro, thiazopyr, thiencarbazone, thiencarbazonemethyl, thifensulfuron, thifensulfuron-methyl, thiobencarb, tiafenacil, tolpyralate, topramezone, tralkoxydim, triafamone, tri-allate, triasulfuron, triaziflam, tribenuron, tribenuron-methyl, triclopyr, trietazine, trifloxysulfuron, trifloxysulfuron sodium, trifludimoxazine, trifluralin, triflusulfuron, triflusulfuron-methyl, tritosulfuron, urea sulfate, vernolate, XDE-848, ZJ-0862, ie 3,4-dichloro-N- {2- [(4,6-dimethoxypyrimidin-2-yl ) oxy] benzyl} aniline, and the following compounds:

Figure imgf000234_0001
Figure imgf000234_0001

Figure imgf000235_0001
Figure imgf000235_0001

Beispiele für Pflanzenwachstumsregulatoren als mögliche Mischungspartner sind: Examples of plant growth regulators as possible mixing partners are:

Acibenzolar, acibenzolar-S-methyl, 5-Aminolävulinsäure, ancymidol, 6-benzylaminopurine, Acibenzolar, acibenzolar-S-methyl, 5-aminolevulinic acid, ancymidol, 6-benzylaminopurine,

Brassinolid, Catechin, chlormequat chloride, cloprop, cyclanilide, 3-(Cycloprop-l-enyl)propionsäure, daminozide, dazomet, n-decanol, dikegulac, dikegulac-sodium, endothal, endothal- dipotassium, -disodium, und mono(N,N-dimethylalkylammonium), ethephon, flumetralin, flurenol, flurenol-butyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfide, indol-3-acetic acid (IAA), 4- indol-3-ylbutyric acid, isoprothiolane, probenazole, Jasmonsäure, Jasmonsäuremethylester, maleic hydrazide, mepiquat chloride, 1 -methylcyclopropene, 2-(l-naphthyl)acetamide, 1 -naphthylacetic acid, 2- naphthyloxyacetic acid, nitrophenolate-mixture, 4-0x0-4 [(2 -phenylethyl)amino]buttersäure, paclobutrazol, N-phenylphthalamic acid, prohexadione, prohexadione-calcium, prohydrojasmone, Salicylsäure, Strigolacton, tecnazene, thidiazuron, triacontanol, trinexapac, trinexapac-ethyl, tsitodef, uniconazole, uniconazole-P. Brassinolide, catechin, chloroformate chloride, cloprop, cyclanilide, 3- (cycloprop-1-enyl) propionic acid, daminozide, dazomet, n-decanol, dikegulac, dikegulac-sodium, endothal, endothaldipotassium, -disodium, and mono (N, N-dimethylalkylammonium), ethephon, flumetralin, flurenol, flurenol-butyl, flurprimidol, forchlorfenuron, gibberellic acid, inabenfide, indole-3-acetic acid (IAA), 4-indol-3-yl-butyric acid, isoprothiolane, probenazole, jasmonic acid, methyl jasmonate maleic hydrazides, mepiquat chloride, 1-methylcyclopropene, 2- (1-naphthyl) acetamide, 1 -naphthylacetic acid, 2-naphthyloxyacetic acid, nitrophenolate-mixture, 4-0x0-4 [(2-phenylethyl) amino] butyric acid, paclobutrazole , N-phenylphthalamic acid, prohexadione, prohexadione-calcium, prohydrojasmone, salicylic acid, strigolactone, tecnazene, thidiazuron, triacontanol, trinexapac, trinexapac-ethyl, tsitodef, uniconazole, uniconazole-P.

Ebenfalls als Kombinationspartner für die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) kommen beispielsweise die folgenden Safener in Frage: Also suitable as combination partners for the compounds of the general formula (I) according to the invention are, for example, the following safeners:

Sl) Verbindungen aus der Gruppe heterocyclischer Carbonsäurederivate: Sl) compounds from the group of heterocyclic carboxylic acid derivatives:

Sla) Verbindungen vom Typ der Dichlorphenylpyrazolin-3-carbonsäure (Sla), vorzugsweise Sl a ) compounds of the type dichlorophenylpyrazoline-3-carboxylic acid (Sl a ), preferably

Verbindungen wie l-(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carbonsäure,  Compounds such as 1- (2,4-dichlorophenyl) -5- (ethoxycarbonyl) -5-methyl-2-pyrazoline-3-carboxylic acid,

1 -(2,4-Dichlorphenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazolin-3-carbonsäureethylester (S 1 - 1 ) ("Mefenpyr-diethyl"), und verwandte Verbindungen, wie sie in der WO-A-91/07874 beschrieben sind;  1- (2,4-dichlorophenyl) -5- (ethoxycarbonyl) -5-methyl-2-pyrazoline-3-carboxylic acid ethyl ester (S 1 - 1) ("mefenpyr-diethyl"), and related compounds as described in WO -A-91/07874;

S lb) Derivate der Dichlorphenylpyrazolcarbonsäure (S lb), vorzugsweise Verbindungen wie S l b ) derivatives of Dichlorphenylpyrazolcarbonsäure (S l b ), preferably compounds such

1 -(2,4-Dichlorphenyl)-5-methylpyrazol-3 -carbonsäureethylester (S 1 -2),  1 - (2,4-dichlorophenyl) -5-methylpyrazole-3-carboxylic acid ethyl ester (S 1 -2),

l-(2,4-Dichlorphenyl)-5-isopropylpyrazol-3-carbonsäureethylester (Sl-3),  Ethyl l- (2,4-dichlorophenyl) -5-isopropylpyrazole-3-carboxylate (Sl-3),

1 -(2,4-Dichlorphenyl)-5-(l , 1 -dimethyl-ethyl)pyrazol-3-carbonsäureethylester (S 1 -4) und verwandte Verbindungen, wie sie in EP-A-333131 und EP-A-269806 beschrieben sind; Derivate der l,5-Diphenylpyrazol-3-carbonsäure (Slc), vorzugsweise Verbindungen wie l-(2,4-Dichlorphenyl)-5-phenylpyrazol-3-carbonsäureethylester (Sl-5), Ethyl 1 - (2,4-dichlorophenyl) -5- (1,1-dimethyl-ethyl) pyrazole-3-carboxylate (S 1 -4) and related compounds as described in EP-A-333131 and EP-A-269806 are described; Derivatives of l, 5-diphenylpyrazole-3-carboxylic acid (Sl c ), preferably compounds such as l- (2,4-dichlorophenyl) -5-phenylpyrazole-3-carboxylic acid ethyl ester (Sl-5),

l-(2-Chlorphenyl)-5-phenylpyrazol-3-carbonsäuremethylester (Sl-6) und verwandte  1- (2-chlorophenyl) -5-phenylpyrazole-3-carboxylic acid methyl ester (Sl-6) and related

Verbindungen wie sie beispielsweise in der EP-A-268554 beschrieben sind;  Compounds as described, for example, in EP-A-268554;

Verbindungen vom Typ der Triazolcarbonsäuren (Sld), vorzugsweise Verbindungen wie Fenchlorazol(-ethylester), d.h. l-(2,4-Dichlorphenyl)-5-trichlormethyl-(lH)-l,2,4-triazol-3- carbonsäureethylester (Sl-7), und verwandte Verbindungen, wie sie in EP-A- 174562 und EP-A-346620 beschrieben sind; Compounds of the type of triazolecarboxylic acids (Sl d ), preferably compounds such as fenchlorazole (ethyl ester), ie ethyl 1- (2,4-dichlorophenyl) -5-trichloromethyl- (1H) -l, 2,4-triazole-3-carboxylate ( Sl-7), and related compounds as described in EP-A-174562 and EP-A-346620;

Verbindungen vom Typ der 5-Benzyl- oder 5-Phenyl-2-isoxazolin-3- carbonsäure, oder der 5,5- Diphenyl-2-isoxazolin-3-carbonsäure(Sle), vorzugsweise Verbindungen wie Compounds of the 5-benzyl- or 5-phenyl-2-isoxazoline-3-carboxylic acid type or of the 5,5-diphenyl-2-isoxazoline-3-carboxylic acid (Sl e ), preferably compounds such as

5-(2,4-Dichlorbenzyl)-2-isoxazolin-3-carbonsäureethylester (Sl-8) oder  5- (2,4-dichlorobenzyl) -2-isoxazoline-3-carboxylic acid ethyl ester (Sl-8) or

5-Phenyl-2-isoxazolin-3-carbonsäureethylester (Sl-9) und verwandte Verbindungen, wie sie in WO-A-91/08202 beschrieben sind, bzw. 5,5-Diphenyl-2-isoxazolin-carbonsäure (Sl-10) oder 5,5-Diphenyl-2-isoxazolin-3-carbonsäureethylester (Sl-11) ("Isoxadifen-ethyl")  5-phenyl-2-isoxazoline-3-carboxylic acid ethyl ester (Sl-9) and related compounds, as described in WO-A-91/08202, or 5,5-diphenyl-2-isoxazoline-carboxylic acid (Sl-10 ) or ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate (Sl-11) ("isoxadifen-ethyl")

oder -n-propylester (Sl-12) oder 5-(4-Fluorphenyl)-5-phenyl-2-isoxazolin-3-carbon- säureethylester (Sl-13), wie sie in der Patentanmeldung WO-A-95/07897 beschrieben sind.  or -n-propyl ester (Sl-12) or 5- (4-fluorophenyl) -5-phenyl-2-isoxazoline-3-carboxylic acid ethyl ester (Sl-13), as described in the patent application WO-A-95/07897 are described.

Verbindungen aus der Gruppe der 8-Chinolinoxyderivate (S2): Compounds from the group of the 8-quinolinoxy derivatives (S2):

Verbindungen vom Typ der 8-Chinolinoxyessigsäure (S2a), vorzugsweise Compounds of the 8-quinolinoxyacetic acid type (S2 a ), preferably

(5 -Chlort ^-chinolinoxy)essij *säure-(l-methylhexyl)-ester ("Cloquintocet-mexyl") (S2-1), (5-chloro-quinolinoxy) -acetic acid (1-methylhexyl) ester ("cloquintocet-mexyl") (S2-1),

(5 -Chlort -chinolinoxy)essi *säure-(l,3-dimethyl-but-l -yl)-ester (S2-2), (5-chloro-quinolinoxy) -acetic acid (1,3-dimethyl-but-1-yl) ester (S2-2),

(5 -Chlort -chinolinoxy)essi *säure-4-allyl-oxy-butylester (S2-3),  (5-chloro-quinolinoxy) -acetic acid 4-allyl-oxy-butyl ester (S2-3),

(5 -Chlort -chinolinoxy)essi ^säure- 1 -allyloxy-prop-2-ylester (S2-4),  (5-chloro-quinolinoxy) -acetic acid 1 -allyloxy-prop-2-yl ester (S2-4),

(5 -Chlort ^-chinolinoxy)essij jsäureethylester (S2-5),  (5-chloro-quinolinoxy) ethyl acetate (S2-5),

(5 -Chlort ^-chinolinoxy)essij jsäuremethylester (S2-6),  Methyl (5-chloro-quinolinoxy) -acetate (S2-6),

(5 -Chlort ^-chinolinoxy)essij jsäureallylester (S2-7),  (5-chloro-quinolinoxy) -acetyl-allyl ester (S2-7),

(5 -Chlort -chinolinoxy)essi *säure-2-(2-propyliden-iminoxy)- 1 -ethylester (S2-8),  (5-chloro-quinolinoxy) -acetic acid 2- (2-propylidene-iminoxy) -1-ethyl-ester (S2-8),

(5 -Chlort -chinolinoxy)essi *säure-2-oxo-prop-l -ylester (S2-9) und verwandte Verbindungen wie sie in EP-A-86750, EP-A-94349 und EP-A-191736 oder EP-A-0 492 366 beschrieben sind, sowie (5-Chlor-8-chinolinoxy)essigsäure (S2-10), deren Hydrate und Salze, beispielsweise deren Lithium-, Natrium- Kalium-, Kalzium-, Magnesium-, Aluminium-, Eisen-, Ammonium-, quartäre Ammonium-, Sulfonium-, oder Phosphoniumsalze wie sie in der WO-A-2002/34048 beschrieben sind;  (5-chloro-quinolinoxy) -acetic acid 2-oxo-prop-1-yl-ester (S2-9) and related compounds as described in EP-A-86750, EP-A-94349 and EP-A-191736 or EP -A- 0 492 366 and (5-chloro-8-quinolinoxy) acetic acid (S2-10), their hydrates and salts, for example their lithium, sodium, potassium, calcium, magnesium, aluminum, Iron, ammonium, quaternary ammonium, sulfonium or phosphonium salts as described in WO-A-2002/34048;

S2b) Verbindun gen vom Typ der (5-Chlor-8-chinolinoxy)malonsäure (S2b), vorzugsweise S2 b ) compounds of the type of (5-chloro-8-quinolinoxy) malonic acid (S2 b ), preferably

Verbindungen wie (5-Chlor-8-chinolinoxy)malonsäurediethylester, (5-Chlor-8-chinolinoxy)malonsäurediallylester, Compounds such as diethyl (5-chloro-8-quinolinoxy) malonate, (5-chloro-8-quinolinoxy) malonate,

(5-Chlor-8-chinolinoxy)malonsäure-methyl-ethylester und verwandte Verbindungen, wie sie in EP-A-0 582 198 beschrieben sind.  (5-chloro-8-quinolinoxy) malonic acid methyl ethyl ester and related compounds as described in EP-A-0 582 198.

S3) Wirkstoffe vom Typ der Dichloracetamide (S3), die häufig als Vorauflaufsafener S3) Dichloroacetamide-type drugs (S3), often used as pre-emergence safeners

(bodenwirksame Safener) angewendet werden, wie z. B.  (soil-active safeners) are used, such. B.

"Dichlormid" (N,N-Diallyl-2,2-dichloracetamid) (S3-1),  "Dichloromid" (N, N-diallyl-2,2-dichloroacetamide) (S3-1),

"R-29148" (3-Dichloracetyl-2,2,5-trimethyl-l ,3-oxazolidin) der Firma Stauffer (S3-2), "R-28725" (3-Dichloracetyl-2,2,-dimethyl-l ,3-oxazolidin) der Firma Stauffer (S3-3),  "R-29148" (3-dichloroacetyl-2,2,5-trimethyl-1,3-oxazolidine) from Stauffer (S3-2), "R-28725" (3-dichloro-acetyl-2,2-dimethyl) 1, 3-oxazolidine) from Stauffer (S3-3),

"Benoxacor" (4-Dichloracetyl-3,4-dihydro-3-methyl-2H-l ,4-benzoxazin) (S3-4),  "Benoxacor" (4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine) (S3-4),

"PPG-1292" (N-Allyl-N-[(l ,3-dioxolan-2-yl)-methyl]-dichloracetamid) der Firma PPG  "PPG-1292" (N-allyl-N - [(1,3-dioxolan-2-yl) -methyl] -dichloroacetamide) from PPG

Industries (S3-5),  Industries (S3-5),

"DKA-24" (N-Allyl-N-[(allylaminocarbonyl)methyl]-dichloracetamid) der Firma Sagro-Chem (S3-6),  "DKA-24" (N-allyl-N - [(allylaminocarbonyl) methyl] -dichloroacetamide) from Sagro-Chem (S3-6),

"AD-67" oder "MON 4660" (3-Dichloracetyl-l -oxa-3-aza-spiro[4,5]decan) der Firma  "AD-67" or "MON 4660" (3-dichloroacetyl-1-oxa-3-aza-spiro [4,5] decane) from the company

Nitrokemia bzw. Monsanto (S3-7),  Nitrokemia and Monsanto (S3-7),

"TI-35" (1 -Dichloracetyl-azepan) der Firma TRI-Chemical RT (S3-8),  "TI-35" (1-dichloroacetyl-azepane) from TRI-Chemical RT (S3-8),

"Diclonon" (Dicyclonon) oder "BAS 145138" oder "LAB 145138" (S3-9)  "Diclonone" (dicyclonone) or "BAS 145138" or "LAB 145138" (S3-9)

((RS)-l -Dichloracetyl-3,3,8a-trimethylperhydropyrrolo[l ,2-a]pyrimidin-6-on) der Firma BASF, "Furilazol" oder "MON 13900" ((RS)-3-Dichloracetyl-5-(2-furyl)-2,2-dimethyloxazolidin) (S3-10), sowie dessen (R)-Isomer (S3-1 1).  ((RS) -1-dichloroacetyl-3,3,8a-trimethylperhydropyrrolo [1,2-a] pyrimidin-6-one) from BASF, "furilazole" or "MON 13900" ((RS) -3-dichloroacetyl) 5- (2-furyl) -2,2-dimethyloxazolidine) (S3-10) and its (R) isomer (S3-1 1).

S4) Verbindungen aus der Klasse der Acylsulfonamide (S4): S4) Compounds of the class of acylsulfonamides (S4):

S4a) N-Acylsulfonamide der Formel (S4a) und deren Salze wie sie in der WO-A-97/45016 S4 a ) N-acylsulfonamides of the formula (S4 a ) and salts thereof as described in WO-A-97/45016

beschrieben sind,  are described

Figure imgf000237_0001
Figure imgf000237_0001

RA1 (Ci-C6)Alkyl, (C3-C6)Cycloalkyl, wobei die 2 letztgenannten Reste durch VA RA 1 (C 1 -C 6) alkyl, (C 3 -C 6) cycloalkyl, where the 2 last-mentioned radicals are represented by VA

Substituenten aus der Gruppe Halogen, (Ci-C i)Alkoxy, (Ci-C6)Haloalkoxy und (Ci- C4)Alkylthio und im Falle cyclischer Reste auch durch (Ci-C i)Alkyl und (Ci-C4)Haloalkyl substituiert sind;  Substituents from the group halogen, (Ci-C i) alkoxy, (Ci-C6) haloalkoxy and (Ci-C4) alkylthio and in the case of cyclic radicals by (Ci-C i) alkyl and (Ci-C4) haloalkyl are substituted ;

RA2 Halogen, (Ci-C4)Alkyl, (Ci-C4)Alkoxy, CF3; ηΐΑ 1 oder 2; RA 2 halogen, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, CF 3; ηΐΑ 1 or 2;

VA ist 0, 1, 2 oder 3 bedeuten; VA is 0, 1, 2 or 3;

Verbindungen vom Typ der 4-(Benzoylsulfamoyl)benzamide der Formel (S4b) und deren Salze, wie sie in der WO-A-99/16744 beschrieben sind, Compounds of the 4- (benzoylsulfamoyl) benzamide of the formula (S4 b) and salts thereof, as described in WO-A-99/16744,

Figure imgf000238_0001
worin
Figure imgf000238_0001
wherein

RB1, RB2 unabhängig voneinander Wasserstoff, (Ci-C6)Alkyl, (C3-C6)Cycloalkyl, (C3- C6)Alkenyl, (C3-C6)Alkinyl, RB 1 , RB 2 independently of one another are hydrogen, (C 1 -C 6 ) -alkyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -alkenyl, (C 3 -C 6 ) -alkynyl,

RB3 Halogen, (Ci-C4)Alkyl, (Ci-C4)Haloalkyl oder (Ci-C4)Alkoxy und ms 1 oder 2 bedeuten, z.B. solche worin RB 3 is halogen, (Ci-C 4 ) alkyl, (Ci-C 4 ) haloalkyl or (Ci-C 4 ) alkoxy and ms is 1 or 2, for example those in which

RB1 = Cyclopropyl, RB 2 = Wasserstoff und (RB3) = 2-OMe ist ("Cyprosulfamide", S4-1), RB 1 = cyclopropyl, R B 2 = hydrogen and (RB 3 ) = 2-OMe ("Cyprosulfamide", S4-1),

RB1 = Cyclopropyl, RB 2 = Wasserstoff und (RB3) = 5-Cl-2-OMe ist (S4-2), RB 1 = cyclopropyl, R B 2 = hydrogen and (RB 3 ) = 5-Cl-2-OMe (S4-2),

RB1 = Ethyl, RB 2 = Wasserstoff und (RB3) = 2-OMe ist (S4-3), RB 1 = ethyl, R B 2 = hydrogen and (RB 3 ) = 2-OMe (S4-3),

RB1 = Isopropyl, RB 2 = Wasserstoff und (RB3) = 5-Cl-2-OMe ist (S4-4) und RB 1 = isopropyl, R B 2 = hydrogen and (RB 3 ) = 5-Cl-2-OMe is (S4-4) and

RB1 = Isopropyl, RB 2 = Wasserstoff und (RB3) = 2-OMe ist (S4-5); RB 1 = isopropyl, R B 2 = hydrogen and (RB 3 ) = 2-OMe (S4-5);

Verbindungen aus der Klasse der Benzoylsulfamoylphenylharnstoffe der Formel (S4C), wie sie in der EP-A-365484 beschrieben sind, Compounds of the class of the benzoylsulfamoylphenylureas of the formula (S4 C ) as described in EP-A-365484,

Figure imgf000238_0002
worin
Figure imgf000238_0002
wherein

2 2

Rc , Rc unabhängig voneinander Wasserstoff, (Ci-Cg)Alkyl, (C3-Cg)Cycloalkyl, (C3- Rc, Rc independently of one another are hydrogen, (Ci-Cg) alkyl, (C3-Cg) cycloalkyl, (C3-

C6)Alkenyl, (C3-C6)Alkinyl, C 6 ) alkenyl, (C 3 -C 6 ) alkynyl,

Rc3 Halogen, (Ci-C4)Alkyl, (Ci-C4)Alkoxy, CF3 und nie 1 oder 2 bedeuten; beispielsweise Rc 3 is halogen, (Ci-C 4 ) alkyl, (Ci-C 4 ) alkoxy, CF 3 and never 1 or 2; for example

1 - [4-(N-2-Methoxybenzoylsulfamoyl)phenyl] -3 -methylharnstoff, 1 - [4- (N-2-methoxybenzoylsulfamoyl) phenyl] -3-methylurea,

1 - [4-(N-2-Methoxybenzoylsulfamoyl)phenyl] -3 ,3 -dimethylharnstoff,  1 - [4- (N-2-methoxybenzoylsulfamoyl) phenyl] -3,3-dimethylurea,

l-[4-(N-4,5-Dimethylbenzoylsulfamoyl)phenyl]-3-metliylliarnstoff; S4d) Verbindungen vom Typ der N-Phenylsulfonylterephthalamide der Formel (S4d) und deren Salze, die z.B. bekannt sind aus CN 101838227, l- [4- (N-4,5-Dimethylbenzoylsulfamoyl) phenyl] -3-metliylliarnstoff; S4 d ) compounds of the N-phenylsulfonylterephthalamide type of the formula (S4 d ) and salts thereof which are known, for example, from CN 101838227,

Figure imgf000239_0001
Figure imgf000239_0001

RD 4 Halogen, (Ci-C4)Alkyl, (Ci-C4)Alkoxy, CF3; mD 1 oder 2; R D 4 is halogen, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, CF 3; mD 1 or 2;

RD 5 Wasserstoff, (Ci-C6)Alkyl, (C3-C6)Cycloalkyl, (C2-C6)Alkenyl, (C2-C6)Alkinyl, (C5- Ce)Cycloalkenyl bedeutet. R D 5 is hydrogen, (C 1 -C 6 ) alkyl, (C 3 -C 6 ) cycloalkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 5 -C 6 ) cycloalkenyl.

S5) Wirkstoffe aus der Klasse der Hydroxyaromaten und der aromatisch-aliphatischen S5) active ingredients from the class of hydroxyaromatic and aromatic-aliphatic

Carbonsäurederivate (S5), z.B.  Carboxylic acid derivatives (S5), e.g.

3,4,5-Triacetoxybenzoesäureethylester, 3,5-Dimethoxy-4-hydroxybenzoesäure, 3,5- Dihydroxybenzoesäure, 4-Hydroxysalicylsäure, 4-Fluorsalicyclsäure, 2-Hydroxyzimtsäure, 2,4- Dichlorzimtsäure, wie sie in der WO-A-2004/084631, WO-A-2005/015994, WO-A- 2005/016001 beschrieben sind.  3,4,5-triacetoxybenzoic acid ethyl ester, 3,5-dimethoxy-4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 4-hydroxysalicylic acid, 4-fluorosalicyclic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid, as described in WO-A- 2004/084631, WO-A-2005/015994, WO-A-2005/016001.

S6) Wirkstoffe aus der Klasse der l,2-Dihydrochinoxalin-2-one (S6), z.B. S6) active compounds from the class of 1,2-dihydroquinoxaline-2-ones (S6), e.g.

l-Methyl-3-(2-thienyl)-l,2-dihydrochinoxalin-2-on, l-Methyl-3-(2-thienyl)-l,2-dihydro- chinoxalin-2-thion, l-(2-Aminoethyl)-3-(2-thienyl)-l,2-dihydro-chinoxalin-2-on-hydrochlorid, l-(2-Methylsulfonylaminoethyl)-3-(2-thienyl)-l,2-dihydro-chinoxalin-2-on, wie sie in der WO- A-2005/112630 beschrieben sind. 1-methyl-3- (2-thienyl) -1,2-dihydroquinoxalin-2-one, 1-methyl-3- (2-thienyl) -1,2-dihydro- quinoxaline-2-thione, 1- (2-aminoethyl) -3- (2-thienyl) -1,2-dihydroquinoxaline-2-one hydrochloride, 1- (2-methylsulfonylaminoethyl) -3- (2-thienyl ) -l, 2-dihydro-quinoxalin-2-one, as described in WO-A-2005/112630.

Verbindungen aus der Klasse der Diphenylmethoxyessigsäurederivate (S7), z.B. Compounds from the class of diphenylmethoxyacetic acid derivatives (S7), e.g.

Diphenylmethoxyessigsäuremethylester (CAS-Reg.Nr. 41858-19-9) (S7-1),  Methyl diphenylmethoxyacetate (CAS No. 41858-19-9) (S7-1),

Diphenylmethoxyessigsäureethylester oder Diphenylmethoxyessigsäure wie sie in der WO-A- 98/38856 beschrieben sind.  Diphenylmethoxyessigsäureethylester or Diphenylmethoxyessigsäure as described in WO-A-98/38856.

Verbindungen der Formel (S8), wie sie in der WO-A-98/27049 beschrieben sind, Compounds of the formula (S8) as described in WO-A-98/27049,

Figure imgf000240_0001
Figure imgf000240_0001

worin die Symbole und Indizes folgende Bedeutungen haben: wherein the symbols and indices have the following meanings:

RD1 ist Halogen, (Ci-C4)Alkyl, (Ci-C4)Haloalkyl, (Ci-C4)Alkoxy, (Ci-C4)Haloalkoxy, RD2 ist Wasserstoff oder (Ci-C4)Alkyl, RD 1 is halogen, (Ci-C 4) alkyl, (Ci-C 4) haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, RD 2 is hydrogen or (Ci-C 4) alkyl,

RD3 ist Wasserstoff, (Ci-Cg)Alkyl, (C2-C4)Alkenyl, (C2-C4)Alkinyl, oder Aryl, wobei jeder der vorgenannten C-haltigen Reste unsubstituiert oder durch einen oder mehrere, vorzugsweise bis zu drei gleiche oder verschiedene Reste aus der Gruppe, bestehend aus Halogen und Alkoxy substituiert ist; oder deren Salze, nD ist eine ganze Zahl von 0 bis 2. RD 3 is hydrogen, (Ci-Cg) alkyl, (C 2 -C 4 ) alkenyl, (C 2 -C 4 ) alkynyl, or aryl, wherein each of the aforementioned C-containing radicals unsubstituted or by one or more, preferably up to three identical or different radicals from the group consisting of halogen and alkoxy substituted; or their salts, nD is an integer from 0 to 2.

S9) Wirkstoffe aus der Klasse der 3-(5-Tetrazolylcarbonyl)-2-chinolone (S9), z.B. S9) Agents from the class of 3- (5-tetrazolylcarbonyl) -2-quinolones (S9), e.g.

1 ,2-Dihydro-4-hydroxy- 1 -ethyl-3-(5-tetrazolylcarbonyl)-2-chinolon (CAS-Reg.Nr. : 219479- 18- 2), l,2-Dihydro-4-hydroxy-l-methyl-3-(5-tetrazolyl-carbonyl)-2-chinolon (CAS-Reg.Nr.  1, 2-dihydro-4-hydroxy-1-ethyl-3- (5-tetrazolylcarbonyl) -2-quinolone (CAS Reg. No. 219479-18-2), 1,2-dihydro-4-hydroxy 1-methyl-3- (5-tetrazolyl-carbonyl) -2-quinolone (CAS Reg.

95855-00-8), wie sie in der WO-A- 1999/000020 beschrieben sind.  95855-00-8), as described in WO-A-1999/000020.

S 10) Verbindungen der Formeln (S 10a) oder (S 10b), wie sie in der WO-A-2007/023719 und WO-A-2007/023764 beschrieben sind,

Figure imgf000241_0001
S 10) compounds of the formulas (S 10 a ) or (S 10 b ), as described in WO-A-2007/023719 and WO-A-2007/023764,
Figure imgf000241_0001

(S10a) (S10b) (S10 a) (S10 b)

worin wherein

RE1 Halogen, (Ci-C4)Alkyl, Methoxy, Nitro, Cyano, CF3, OCF3 YE, ZE unabhängig voneinander O oder S, ηε eine ganze Zahl von 0 bis 4, RE 1 is halogen, (C 1 -C 4 ) alkyl, methoxy, nitro, cyano, CF 3 , OCF 3 YE, ZE independently of one another are O or S, η is an integer from 0 to 4,

RE2 (Ci-Ci6)Alkyl, (C2-C6)Alkenyl, (C3-C6)Cycloalkyl, Aryl; Benzyl, Halogenbenzyl, RE3 Wasserstoff oder (Ci-C6)Alkyl bedeuten. RE 2 (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 3 -C 6 ) cycloalkyl, aryl; Benzyl, halobenzyl, RE 3 is hydrogen or (Ci-C6) alkyl.

51 1) Wirkstoffe vom Typ der Oxyimino- Verbindungen (Si l), die als Saatbeizmittel bekannt sind, wie z. B. 51 1) Active ingredients of the type of oxyimino compounds (Si l), which are known as seed dressing, such. B.

"Oxabetrinil" ((Z)-l ,3-Dioxolan-2-ylmethoxyimino(phenyl)acetonitril) (Sl 1 -1), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist,  "Oxabetrinil" ((Z) -l, 3-dioxolan-2-ylmethoxyimino (phenyl) acetonitrile) (Sl 1 -1), which is known as millet safener for millet against damage by metolachlor,

"Fluxofenim" (l -(4-Chlorphenyl)-2,2,2-trifluor-l -ethanon-0-(l ,3-dioxolan-2-ylmethyl)-oxim) (S l 1 -2), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist, und "Fluxofenim" (1- (4-chlorophenyl) -2,2,2-trifluoro-1-ethanone 0- (1,3-dioxolan-2-ylmethyl) -oxime) (S l 1 -2), which was used as a Seed pickling safener for millet is known against damage from metolachlor, and

"Cyometrinil" oder "CGA-43089" ((Z)-Cyanomethoxyimino(phenyl)acetonitril) (S l l -3), das als Saatbeiz-Safener für Hirse gegen Schäden von Metolachlor bekannt ist. "Cyometrinil" or "CGA-43089" ((Z) -cyanomethoxyimino (phenyl) acetonitrile) (S l l -3), which is known as a seed safener for millet against damage by metolachlor.

512) Wirkstoffe aus der Klasse der Isothiochromanone (S 12), wie z.B. Methyl- [(3- oxo- 1H-2- benzothiopyran-4(3H)-yliden)methoxy]acetat (CAS-Reg.Nr. 205121 -04-6) (S 12-1) und verwandte Verbindungen aus WO-A-1998/13361. 512) Isothiochromanone (S 12) class agents, such as Methyl [(3-oxo-1H-2-benzothiopyran-4 (3H) -ylidene) methoxy] acetate (CAS Reg. No. 205121 -04-6) (S 12-1) and related compounds of WO-A -1998 / 13361.

513) Eine oder mehrere Verbindungen aus Gruppe (S13): 513) One or more compounds from group (S13):

"Naphthalic anhydrid" (1 ,8-Naphthalindicarbonsäureanhydrid) (S13-1), das als Saatbeiz-Safener für Mais gegen Schäden von Thiocarbamatherbiziden bekannt ist, "Naphthalene anhydride" (1,8-naphthalenedicarboxylic anhydride) (S13-1), which is known as a seed safener for corn against damage by thiocarbamate herbicides.

"Fenclorim" (4,6-Dichlor-2-phenylpyrimidin) (S13-2), das als Safener für Pretilachlor in gesätem Reis bekannt ist, "Flurazole" (Benzyl-2-chlor-4-trifluormethyl-l ,3-thiazol-5-carboxylat) (S 13-3), das als Saatbeiz-Safener für Hirse gegen Schäden von Alachlor und Metolachlor bekannt ist, "Fenclorim" (4,6-dichloro-2-phenylpyrimidine) (S13-2), known as safener for pretilachlor in sown rice, "Flurazole" (benzyl-2-chloro-4-trifluoromethyl-1,3-thiazole-5-carboxylate) (S 13-3), which is known as a seeder-safener for millet against damage by alachlor and metolachlor,

"CL 304415" (CAS-Reg.Nr. 31541 -57-8) "CL 304415" (CAS No. 31541 -57-8)

(4-Carboxy-3,4-dihydro-2H-l -benzopyran-4-essigsäure) (S13-4) der Firma American  (4-carboxy-3,4-dihydro-2H-1-benzopyran-4-acetic acid) (S13-4) from American

Cyanamid, das als Safener für Mais gegen Schäden von Imidazolinonen bekannt ist,  Cyanamide, which is known as safener for maize against damage of imidazolinones,

"MG 191 " (CAS-Reg.Nr. 96420-72-3) (2-Dichlormethyl-2-methyl-l ,3-dioxolan) (S13-5) der Firma Nitrokemia, das als Safener für Mais bekannt ist, "MG 191" (CAS Reg. No. 96420-72-3) (2-dichloromethyl-2-methyl-1,3-dioxolane) (S13-5) from Nitrokemia, which is known as safener for corn,

"MG 838" (CAS-Reg.Nr. 133993-74-5) "MG 838" (CAS Reg. No. 133993-74-5)

(2-propenyl l -oxa-4-azaspiro[4.5]decan-4-carbodithioat) (S13-6) der Firma Nitrokemia "Disulfoton" (0,0-Diethyl S-2-ethylthioethyl phosphordithioat) (S13-7),  (2-propenyl 1 -oxa-4-azaspiro [4.5] decane-4-carbodithioate) (S13-6) from Nitrokemia "Disulfoton" (O-diethyl S-2-ethylthioethyl phosphorodithioate) (S13-7),

"Dietholate" (0,0-Diethyl-O-phenylphosphorothioat) (S 13-8), "Dietholate" (0,0-diethyl-O-phenyl phosphorothioate) (S 13-8),

"Mephenate" (4-Chlorphenyl-methylcarbamat) (S 13-9). "Mephenate" (4-chlorophenyl methylcarbamate) (S 13-9).

S 14) Wirkstoffe, die neben einer herbiziden Wirkung gegen Schadpflanzen auch Safenerwirkung an Kulturpflanzen wie Reis aufweisen, wie z. B. S 14) active substances which, in addition to a herbicidal activity against harmful plants, also have safener action on crops such as rice, such as, for example, rice. B.

"Dimepiperate" oder "MY-93" (S-\ -Methyl- 1 -phenylethyl-piperidin-l -carbothioat), das als "Dimepiperate" or "MY-93" (S-methyl-1-phenylethyl-piperidine-1-carbothioate), which is described as

Safener für Reis gegen Schäden des Herbizids Molinate bekannt ist, Safener for rice against damage of the herbicide Molinate is known

"Daimuron" oder "SK 23" (l -(l -Methyl-l -phenylethyl)-3-p-tolyl-harnstoff), das als Safener für Reis gegen Schäden des Herbizids Imazosulfuron bekannt ist, "Daimuron" or "SK 23" (1- (1-methyl-1-phenylethyl) -3-p-tolyl-urea) known as a safener for rice against damage by the herbicide imazosulfuron,

"Cumyluron" = "JC-940" (3-(2-Chlorphenylmethyl)-l -(l -methyl-l -phenyl-ethyl)harnstoff, siehe JP-A-60087270), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "Cumyluron" = "JC-940" (3- (2-chlorophenylmethyl) -1- (1-methyl-1-phenyl-ethyl) urea, see JP-A-60087270) which can be used as safener for rice against damage of some herbicides is known

"Methoxyphenon" oder "NK 049" (3,3'-Dimethyl-4-methoxy-benzophenon), das als Safener für Reis gegen Schäden einiger Herbizide bekannt ist, "Methoxyphenone" or "NK 049" (3,3'-dimethyl-4-methoxy-benzophenone), which is known as safener for rice against damage of some herbicides,

"CSB" (l -Brom-4-(chlormethylsulfonyl)benzol) von Kumiai, (CAS-Reg.Nr. 54091 -06-4), das als Safener gegen Schäden einiger Herbizide in Reis bekannt ist. S 15) Verbindungen der Formel (S 15) oder deren Tautomere,

Figure imgf000243_0001
wie sie in der WO-A-2008/131861 und WO-A-2008/131860 beschrieben sind, worin einen (Ci-C6)Haloalkylrest bedeutet und "CSB" (1-Bromo-4- (chloromethylsulfonyl) benzene) from Kumiai, (CAS Registry No. 54091-06-4), which is known as a safener against damage of some herbicides in rice. S 15) compounds of the formula (S 15) or their tautomers,
Figure imgf000243_0001
as described in WO-A-2008/131861 and WO-A-2008/131860, wherein a (Ci-C6) haloalkyl radical means and

Wasserstoff oder Halogen bedeutet und unabhängig voneinander Wasserstoff, (Ci-Ci6)Alkyl, (C2-Ci6)Alkenyl oder Is hydrogen or halogen and independently of one another hydrogen, (Ci-Ci6) alkyl, (C2-Ci6) alkenyl or

(C2-Ci6)Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C i)Alkoxy, (Ci-C i)Haloalkoxy, (Ci-C4)Alkylthio, (Ci-C4)Alkylamino, Di[(Ci-C4)alkyl]-amino, [(Ci-C4)Alkoxy]- carbonyl, [(Ci-C4)Haloalkoxy]-carbonyl, (C3-C6)Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, oder (C3-C6)Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)Alkyl, (Ci-C4)Haloalkyl, (Ci-C4)Alkoxy, (Ci-C4)Haloalkoxy, (Ci-C4)Alkylthio, (Ci-C4)Alkylamino, Di[(Ci- C4)alkyl]-amino, [(Ci-C4)Alkoxy]-carbonyl, [(Ci-C4)Haloalkoxy]-carbonyl, (C 2 -C 6) alkynyl, each of the last-mentioned 3 unsubstituted or by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C i) alkoxy, (Ci-C i) haloalkoxy, (Ci-C 4 ) alkylthio, (C 1 -C 4 ) alkylamino, di [(C 1 -C 4 ) alkyl] amino, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, ( C3-C6) cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, and heterocyclyl which is unsubstituted or substituted, is substituted, or (C3-C6) cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3 -C6) cycloalkyl condensed on one side of the ring with a 4 to 6 membered saturated or unsaturated carbocyclic ring, or (C 4 -C 6) cycloalkenyl attached to one side of the ring with a 4 to 6 membered saturated or is condensed unsaturated carbocyclic ring, wherein each of the last-mentioned 4 unsubstituted or by one or more radicals selected from the group consisting of halogen, hydroxy, cyano, (Ci-C 4 ) alkyl, (Ci-C 4) haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (Ci-C 4) alkylthio, (Ci-C 4) alkylamino, di [(Ci- C4) alkyl] amino, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl,

(C3-C6)Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet oder RH3 (Ci-C i)-Alkoxy, (C2-C i)Alkenyloxy, (C2-C6)Alkinyloxy oder (C2-C4)Haloalkoxy bedeutet und RH4 Wasserstoff oder (Ci-C i)-Alkyl bedeutet oder (C 3 -C 6) cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, and heterocyclyl which is unsubstituted or substituted, or denotes RH 3 is (Ci-C i) alkoxy, (C 2 -C i) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 4 ) haloalkoxy and RH 4 is hydrogen or (Ci-C i) -alkyl or

RH3 und RH4 zusammen mit dem direkt gebundenen N-Atom einen vier- bis achtgliedrigen RH 3 and RH 4 together with the directly attached N atom form a four- to eight-membered one

heterocyclischen Ring, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci- C4)Alkyl, (Ci-C4)Haloalkyl, (Ci-C4)Alkoxy, (Ci-C4)Haloalkoxy und (Ci-C4)Alkylthio substituiert ist, bedeutet. heterocyclic ring which, in addition to the N atom, may also contain further hetero ring atoms, preferably up to two further hetero ring atoms from the group consisting of N, O and S, and which may be unsubstituted or substituted by one or more radicals from the group consisting of halogen, cyano, nitro, C 4 ) alkyl, (Ci-C 4 ) haloalkyl, (Ci-C 4 ) alkoxy, (Ci-C 4 ) haloalkoxy and (Ci-C 4 ) alkylthio is substituted, means.

S 16) Wirkstoffe, die vorrangig als Herbizide eingesetzt werden, jedoch auch Safenerwirkung auf Kulturpflanzen aufweisen, z. B. S 16) active substances which are used primarily as herbicides, but also have safener effect on crop plants, eg. B.

(2,4-Dichlorphenoxy)essigsäure (2,4-D), (2,4-dichlorophenoxy) acetic acid (2,4-D),

(4-Chlorphenoxy)essigsäure,  (4-chlorophenoxy) acetic acid,

(R,S)-2-(4-Chlor-o-tolyloxy)propionsäure (Mecoprop),  (R, S) -2- (4-chloro-o-tolyloxy) propionic acid (mecoprop),

4-(2,4-Dichlorphenoxy)buttersäure (2,4-DB),  4- (2,4-dichlorophenoxy) butyric acid (2,4-DB),

(4-Chlor-o-tolyloxy)essigsäure (MCPA),  (4-chloro-o-tolyloxy) acetic acid (MCPA),

4-(4-Chlor-o-tolyloxy)buttersäure,  4- (4-chloro-o-tolyloxy) butyric acid,

4-(4-Chlorphenoxy)buttersäure,  4- (4-chlorophenoxy) butyric acid,

3,6-Dichlor-2-methoxybenzoesäure (Dicamba),  3,6-dichloro-2-methoxybenzoic acid (Dicamba),

l -(Ethoxycarbonyl)ethyl-3,6-dichlor-2-methoxybenzoat (Lactidichlor-ethyl). Bevorzugte Safener in Kombination mit den erfindungsgemäßen Verbindungend der Formel (I) und/oder deren Salze, insbesondere mit den Verbindungen der Formeln (L I) bis (1.182) und/oder deren Salze sind: Cloquintocet-mexyl, Cyprosulfamid, Fenchlorazol-ethylester, Isoxadifen-ethyl, Mefenpyr- diethyl, Fenclorim, Cumyluron, S4-1 und S4-5, und besonders bevorzugte Safener sind: Cloquintocet- mexyl, Cyprosulfamid, Isoxadifen-ethyl und Mefenpyr-diethyl.  L - (ethoxycarbonyl) ethyl 3,6-dichloro-2-methoxybenzoate (lactidichloroethyl). Preferred safeners in combination with the compounds of formula (I) according to the invention and / or their salts, in particular with the compounds of formulas (LI) to (1.182) and / or salts thereof are: cloquintocet-mexyl, cyprosulfamide, fenchlorazole ethyl ester, isoxadifen and particularly preferred safeners are: cloquintocetmexyl, cyprosulfamide, isoxadifen-ethyl and mefenpyr-diethyl.

Biologische Beispiele: Biological examples:

Herbizide Wirkung und Kulturverträglichkeit im Nachauflauf Herbicidal action and post-emergence culture compatibility

Samen von mono- bzw. dikotylen Unkraut- bzw. Kulturpflanzen wurden in Kunststoff- oder Seeds of monocotyledonous or dicotyledonous weeds were cultivated in plastic or

Holzfasertöpfen in sandigem Lehmboden ausgelegt, mit Erde abgedeckt und im Gewächshaus unter kontrollierten Wachstumsbedingungen angezogen. 2 bis 3 Wochen nach der Aussaat wurden die Versuchspflanzen im Einblattstadium behandelt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 1/ha auf die grünen Pflanzenteile gesprüht. Nach ca. 3 Wochen Standzeit der Versuchspflanzen im Gewächshaus, unter optimalen Wachstumsbedingungen, wurde die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen bonitiert. Wood fiber pots laid in sandy loam soil, covered with soil and grown in the greenhouse under controlled growth conditions. 2 to 3 weeks after sowing, the test plants were treated in the single leaf stage. In the form of wettable powders (WP) or as Emulsionskonzentrate (EC) formulated compounds of the invention were then sprayed as an aqueous suspension or emulsion with the addition of 0.5% additive with a water application rate of 600 1 / ha to the green plant parts. After about 3 weeks of life of the test plants in the greenhouse, under optimal growth conditions, the effect of the preparations was scored visually in comparison to untreated controls.

Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie For example, 100% means action = plants are dead, 0% effect = how

Kontrollpflanzen. Control plants.

In den nachstehenden Tabllen AI bis AI 4 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß der Tabellen 1.1 bis 1.182 auf verschiedene Schadpflanzen und einer Aufwandmenge entsprechend 1280 g/ha bzw.320 g/ha, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. In the following Tables AI to AI 4, the effects of selected compounds of the general formula (I) according to Tables 1.1 to 1.182 on various harmful plants and an application rate corresponding to 1280 g / ha or 320 g / ha, which were obtained according to the aforementioned test protocol represented.

Tabelle AI : Nachauflaufwirkung gegen Alopecurus myosuroides (ALOMY) Table AI: Post-emergence effect against Alopecurus myosuroides (ALOMY)

BeispielDosierung example dosage

ALOMY  ALOMY

nummer [g/ha]  number [g / ha]

1.29-167 320 90  1.29-167 320 90

1.71-2 320 90  1.71-2 320 90

1.72-1 320 90  1.72-1 320 90

1.1-167 320 90  1.1-167 320 90

1.71-167 320 80  1.71-167 320 80

1.71-1 320 90  1.71-1 320 90

1.71-167 320 90  1.71-167 320 90

1.72-152 320 90  1.72-152 320 90

1.71-1 320 80  1.71-1 320 80

1.71-14 320 90  1.71-14 320 90

1.29-1 320 90  1.29-1 320 90

1.43-1 320 90  1.43-1 320 90

1.34-167 320 90  1.34-167 320 90

1.72-124 320 80  1.72-124 320 80

1.73-167 320 90  1.73-167 320 90

1.33-152 320 80  1.33-152 320 80

1.6-167 320 80  1.6-167 320 80

1.71-89 320 90  1.71-89 320 90

1.71-152 320 80  1.71-152 320 80

1.71-16 320 90  1.71-16 320 90

1.71-17 320 80  1.71-17 320 80

1.29-101 320 90  1.29-101 320 90

1.71-19 320 80  1.71-19 320 80

1.43-303 320 90  1.43-303 320 90

1.72-167 320 80 BeispielDosierung 1.72-167 320 80 example dosage

ALOMY  ALOMY

nummer [g/ha]  number [g / ha]

1.34-101 320 80  1.34-101 320 80

1.71-26 320 90  1.71-26 320 90

1.71-211 320 80  1.71-211 320 80

1.72-59 320 90  1.72-59 320 90

1.71-59 320 80  1.71-59 320 80

1.127-167 320 80  1.127-167 320 80

1.5-152 320 80  1.5-152 320 80

1.71-108 320 80  1.71-108 320 80

1.71-15 320 80  1.71-15 320 80

1.72-61 320 90  1.72-61 320 90

1.1-152 320 90  1.1-152 320 90

1.127-101 320 80  1.127-101 320 80

1.81-1 320 90  1.81-1 320 90

Tabelle A2: Nachauflaufwirkung gegen Cyperus esculentus (CYPES) Table A2: Post-emergence effect against Cyperus esculentus (CYPES)

Figure imgf000246_0001
Figure imgf000246_0001

Tabelle A3 : Nachauflaufwirkung gegen Digitaria sanguinalis (DIGSA) Table A3: Postemergence action against Digitaria sanguinalis (DIGSA)

BeispielDosierung example dosage

DIGSA  DIGSA

nummer [g/ha]  number [g / ha]

1.71-1 320 90  1.71-1 320 90

1.71-296 320 80  1.71-296 320 80

1.34-167 320 80  1.34-167 320 80

1.71-298 320 80  1.71-298 320 80

1.34-101 320 80 Tabelle A4: Nachauflaufwirkung gegen Echinochloa cras-galli (ECHCG) 1.34-101 320 80 Table A4: Postemergence activity against Echinochloa cras-galli (ECHCG)

BeispielDosierung example dosage

ECHCG  ECHCG

nummer [g/ha]  number [g / ha]

1.29-167 320 80  1.29-167 320 80

1.71-2 320 90  1.71-2 320 90

1.72-1 320 100  1.72-1 320 100

1.1-167 320 100  1.1-167 320 100

1.71-1 320 80  1.71-1 320 80

1.71-167 320 100  1.71-167 320 100

1.71-1 320 80  1.71-1 320 80

1.71-167 320 100  1.71-167 320 100

1.72-152 320 100  1.72-152 320 100

1.71-167 320 80  1.71-167 320 80

1.71-1 320 80  1.71-1 320 80

1.71-296 320 80  1.71-296 320 80

1.29-1 320 80  1.29-1 320 80

1.43-1 320 80  1.43-1 320 80

1.43-167 320 80  1.43-167 320 80

1.71-61 320 100  1.71-61 320 100

1.72-124 320 90  1.72-124 320 90

1.71-166 320 80  1.71-166 320 80

1.33-152 320 80  1.33-152 320 80

1.6-167 320 80  1.6-167 320 80

1.71-89 320 90  1.71-89 320 90

1.71-152 320 80  1.71-152 320 80

1.1-1 320 90  1.1-1 320 90

1.71-16 320 100  1.71-16 320 100

1.71-17 320 90  1.71-17 320 90

1.71-62 320 90  1.71-62 320 90

1.72-194 320 90  1.72-194 320 90

1.43-101 320 80  1.43-101 320 80

1.43-303 320 80  1.43-303 320 80

1.72-167 320 90  1.72-167 320 90

1.74-1 320 100  1.74-1 320 100

1.1-303 320 100  1.1-303 320 100

1.72-59 320 90  1.72-59 320 90

1.71-59 320 90  1.71-59 320 90

1.5-152 320 90  1.5-152 320 90

1.71-108 320 90  1.71-108 320 90

1.72-61 320 90  1.72-61 320 90

1.71-12 320 80  1.71-12 320 80

1.71-24 320 80  1.71-24 320 80

1.1-101 320 80  1.1-101 320 80

1.71-124 320 80 BeispielDosierung 1.71-124 320 80 example dosage

ECHCG  ECHCG

nummer [g/ha]  number [g / ha]

1.1-152 320 80  1.1-152 320 80

1.71-6 320 90  1.71-6 320 90

1.74-124 320 80  1.74-124 320 80

Tabelle A5: Nachauflauiwirkung gegen Lolium rigidum (LOLRI) Table A5: Post-light effect against Lolium rigidum (LOLRI)

BeispielDosierung example dosage

LOLRI  LOLRI

nummer [g/ha]  number [g / ha]

1.72-1 320 80  1.72-1 320 80

1.72-152 320 90  1.72-152 320 90

1.71-1 320 80  1.71-1 320 80

1.71-14 320 80  1.71-14 320 80

1.71-19 320 80  1.71-19 320 80

Tabelle A6: Nachauflauiwirkung gegen Setaria viridis (SETVI) Table A6: Follow-up against Setaria viridis (SETVI)

BeispielDosierung example dosage

SETVI  SETVI

nummer [g/ha]  number [g / ha]

1.29-167 320 90  1.29-167 320 90

1.71-2 320 100  1.71-2 320 100

1.72-1 320 90  1.72-1 320 90

1.1-167 320 90  1.1-167 320 90

1.71-1 320 80  1.71-1 320 80

1.71-167 320 90  1.71-167 320 90

1.71-1 320 90  1.71-1 320 90

1.71-167 320 90  1.71-167 320 90

1.72-152 320 90  1.72-152 320 90

1.71-167 320 80  1.71-167 320 80

1.71-1 320 90  1.71-1 320 90

1.71-296 320 80  1.71-296 320 80

1.71-14 320 80  1.71-14 320 80

1.43-167 320 100  1.43-167 320 100

1.71-76 320 90  1.71-76 320 90

1.71-166 320 80  1.71-166 320 80

1.73-167 320 80  1.73-167 320 80

1.33-152 320 80  1.33-152 320 80

1.6-167 320 80  1.6-167 320 80

1.71-89 320 80  1.71-89 320 80

1.71-152 320 80  1.71-152 320 80

1.71-227 320 80  1.71-227 320 80

1.1-1 320 90 BeispielDosierung 1.1-1 320 90 example dosage

SETVI  SETVI

nummer [g/ha]  number [g / ha]

1.71-16 320 90  1.71-16 320 90

1.71-17 320 80  1.71-17 320 80

1.33-167 320 80  1.33-167 320 80

1.72-194 320 80  1.72-194 320 80

1.71-26 320 80  1.71-26 320 80

1.43-3 320 100  1.43-3 320 100

1.71-211 320 80  1.71-211 320 80

1.1-303 320 90  1.1-303 320 90

1.5-152 320 90  1.5-152 320 90

1.71-228 320 90  1.71-228 320 90

1.71-15 320 90  1.71-15 320 90

1.74-167 320 80  1.74-167 320 80

1.81-167 320 80  1.81-167 320 80

1.1-101 320 80  1.1-101 320 80

1.1-149 320 80  1.1-149 320 80

1.71-168 320 80  1.71-168 320 80

1.71-37 320 80  1.71-37 320 80

1.71-78 320 80  1.71-78 320 80

Tabelle A7: Nachauflaufwirkung gegen Abutilon theophrasti (ABUTH) Table A7: Post-emergence activity against Abutilon theophrasti (ABUTH)

BeispielDosierung example dosage

ABUTH  ABUTH

nummer [g/ha]  number [g / ha]

1.29-167 320 100  1.29-167 320 100

1.71-2 320 80  1.71-2 320 80

1.1-167 320 80  1.1-167 320 80

1.71-167 320 80  1.71-167 320 80

1.71-167 320 80  1.71-167 320 80

1.71-167 320 80  1.71-167 320 80

1.43-1 320 80  1.43-1 320 80

1.34-167 320 80  1.34-167 320 80

1.43-167 320 80  1.43-167 320 80

1.43-214 320 80  1.43-214 320 80

1.6-167 320 80  1.6-167 320 80

1.33-167 320 80  1.33-167 320 80

1.33-101 320 80  1.33-101 320 80

1.29-101 320 90  1.29-101 320 90

1.43-101 320 80  1.43-101 320 80

1.72-167 320 90  1.72-167 320 90

1.34-101 320 90  1.34-101 320 90

1.43-3 320 80  1.43-3 320 80

1.75-167 320 80 BeispielDosierung 1.75-167 320 80 example dosage

ABUTH  ABUTH

nummer [g/ha]  number [g / ha]

1.75-101 320 80  1.75-101 320 80

1.71-194 320 80  1.71-194 320 80

1.81-167 320 80  1.81-167 320 80

1.72-101 320 80  1.72-101 320 80

1.81-101 320 80  1.81-101 320 80

Tabelle A8: Nachauflaufwirkung gegen Amaranthus retroflexus (AMARE) Table A8: Postemergence against Amaranthus retroflexus (AMARE)

BeispielDosierung example dosage

AMARE  AMARE

nummer [g/ha]  number [g / ha]

1.29-167 320 100  1.29-167 320 100

1.72-1 320 80  1.72-1 320 80

1.1-167 320 90  1.1-167 320 90

1.71-1 320 100  1.71-1 320 100

1.71-1 320 80  1.71-1 320 80

1.71-167 320 90  1.71-167 320 90

1.71-167 320 100  1.71-167 320 100

1.71-1 320 80  1.71-1 320 80

1.71-296 320 80  1.71-296 320 80

1.71-14 320 80  1.71-14 320 80

1.43-1 320 80  1.43-1 320 80

1.34-167 320 80  1.34-167 320 80

1.43-167 320 80  1.43-167 320 80

1.71-61 320 80  1.71-61 320 80

1.72-124 320 90  1.72-124 320 90

1.71-166 320 80  1.71-166 320 80

1.73-167 320 90  1.73-167 320 90

1.1-1 320 80  1.1-1 320 80

1.71-16 320 80  1.71-16 320 80

1.71-298 320 90  1.71-298 320 90

1.71-62 320 80  1.71-62 320 80

1.72-194 320 80  1.72-194 320 80

1.74-1 320 100  1.74-1 320 100

1.71-211 320 90  1.71-211 320 90

1.127-167 320 80  1.127-167 320 80

1.71-85 320 80  1.71-85 320 80

1.127-101 320 80  1.127-101 320 80

1.71-193 320 80 Tabelle A9: Nachauflauiwirkung gegen Matricaria inodora (MATIN) 1.71-193 320 80 Table A9: Postemergence against Matricaria inodora (MATIN)

Figure imgf000251_0001
Tabelle A10: Nachauflauiwirkung gegen Fallopia convolvulus (POLCO)
Figure imgf000251_0001
Table A10: Follow-up against Fallopia convolvulus (POLCO)

BeispielDosierung example dosage

POLCO  POLCO

nummer [g/ha]  number [g / ha]

1.29-167 320 100  1.29-167 320 100

1.71-2 320 90  1.71-2 320 90

1.72-1 320 90  1.72-1 320 90

1.1-167 320 80  1.1-167 320 80

1.71-1 320 80  1.71-1 320 80

1.71-1 320 90  1.71-1 320 90

1.72-152 320 80  1.72-152 320 80

1.71-1 320 80  1.71-1 320 80

1.71-296 320 80  1.71-296 320 80

1.71-14 320 90  1.71-14 320 90

1.29-1 320 80  1.29-1 320 80

1.43-1 320 80  1.43-1 320 80

1.34-167 320 80  1.34-167 320 80

1.71-61 320 80  1.71-61 320 80

1.43-214 320 80  1.43-214 320 80

1.71-227 320 80  1.71-227 320 80

1.33-167 320 80  1.33-167 320 80

1.33-101 320 80  1.33-101 320 80

1.43-303 320 80  1.43-303 320 80

1.72-59 320 90 BeispielDosierung 1.72-59 320 90 example dosage

POLCO  POLCO

nummer [g/ha]  number [g / ha]

1.75-167 320 80  1.75-167 320 80

1.71-144 320 80  1.71-144 320 80

1.144-152 320 80  1.144-152 320 80

1.71-102 320 90  1.71-102 320 90

1.71-216 320 80  1.71-216 320 80

Tabelle AI 1 : Nachauflauiwirkung gegen Stellaria media (STEME) Table AI 1: Follow-up action against Stellaria media (STEME)

Figure imgf000252_0001
Figure imgf000252_0001

Tabelle A12: Nachauflauiwirkung gegen Viola tricolor (VIOTR) Table A12: Post-lightening effect against Viola tricolor (VIOTR)

BeispielDosierung example dosage

VIOTR  VIOTR

nummer [g/ha]  number [g / ha]

1.29-167 320 100  1.29-167 320 100

1.71-2 320 90  1.71-2 320 90

1.1-167 320 80  1.1-167 320 80

1.71-1 320 90  1.71-1 320 90

1.71-167 320 90  1.71-167 320 90

1.71-1 320 80  1.71-1 320 80

1.71-167 320 90 BeispielDosierung 1.71-167 320 90 example dosage

VIOTR  VIOTR

nummer [g/ha]  number [g / ha]

1.29-1 320 90  1.29-1 320 90

1.43-167 320 80  1.43-167 320 80

1.71-61 320 80  1.71-61 320 80

1.71-76 320 80  1.71-76 320 80

1.43-214 320 80  1.43-214 320 80

1.73-167 320 100  1.73-167 320 100

1.6-167 320 80  1.6-167 320 80

1.33-167 320 80  1.33-167 320 80

1.33-101 320 80  1.33-101 320 80

1.29-101 320 80  1.29-101 320 80

1.71-62 320 90  1.71-62 320 90

1.43-101 320 90  1.43-101 320 90

1.74-1 320 100  1.74-1 320 100

1.43-3 320 80  1.43-3 320 80

1.127-167 320 90  1.127-167 320 90

1.71-194 320 80  1.71-194 320 80

1.71-24 320 90  1.71-24 320 90

1.72-101 320 90  1.72-101 320 90

1.71-150 320 80  1.71-150 320 80

1.71-149 320 90  1.71-149 320 90

1.74-101 320 100  1.74-101 320 100

1.71-20 320 90  1.71-20 320 90

1.29-3 320 90  1.29-3 320 90

Tabelle AI 3: Nachauflaufwirkung gegen Veronica persica (VERPE) Table AI 3: Post-emergence effect against Veronica persica (VERPE)

BeispielDosierung example dosage

VERPE  VERPE

nummer [g/ha]  number [g / ha]

1.29-167 320 100  1.29-167 320 100

1.71-2 320 80  1.71-2 320 80

1.72-1 320 80  1.72-1 320 80

1.71-1 320 80  1.71-1 320 80

1.71-167 320 90  1.71-167 320 90

1.71-167 320 80  1.71-167 320 80

1.71-296 320 80  1.71-296 320 80

1.71-14 320 80  1.71-14 320 80

1.29-1 320 80  1.29-1 320 80

1.43-1 320 80  1.43-1 320 80

1.34-167 320 80  1.34-167 320 80

1.43-167 320 80  1.43-167 320 80

1.71-61 320 90  1.71-61 320 90

1.71-166 320 80  1.71-166 320 80

1.43-214 320 80 BeispielDosierung 1.43-214 320 80 example dosage

VERPE  VERPE

nummer [g/ha]  number [g / ha]

1.33-152 320 80  1.33-152 320 80

1.71-89 320 80  1.71-89 320 80

1.71-152 320 80  1.71-152 320 80

1.71-227 320 90  1.71-227 320 90

1.29-101 320 80  1.29-101 320 80

1.71-298 320 80  1.71-298 320 80

1.71-62 320 90  1.71-62 320 90

1.71-19 320 80  1.71-19 320 80

1.43-303 320 80  1.43-303 320 80

1.71-26 320 80  1.71-26 320 80

1.71-59 320 80  1.71-59 320 80

1.71-228 320 90  1.71-228 320 90

1.71-12 320 80  1.71-12 320 80

1.74-167 320 90  1.74-167 320 90

1.71-124 320 80  1.71-124 320 80

1.71-144 320 90  1.71-144 320 90

1.71-85 320 80  1.71-85 320 80

1.71-190 320 80  1.71-190 320 80

1.71-143 320 90  1.71-143 320 90

1.71-63 320 80  1.71-63 320 80

1.29-213 320 90  1.29-213 320 90

1.29-214 320 80  1.29-214 320 80

Tabelle A14: Nachauflaufwirkung gegen Hordeum murinum (HORMU) Table A14: Postemergence against Hordeum murinum (HORMU)

BeispielDosierung example dosage

HORMU  Hormu

nummer [g/ha]  number [g / ha]

1.71-152 1280 90  1.71-152 1280 90

1.71-15 1280 100  1.71-15 1280 100

1.71-19 1280 100  1.71-19 1280 100

1.71-76 1280 90  1.71-76 1280 90

1.29-213 1280 90  1.29-213 1280 90

1.71-85 1280 80  1.71-85 1280 80

1.71-124 1280 80  1.71-124 1280 80

1.71-14 1280 100  1.71-14 1280 100

1.71-37 1280 80  1.71-37 1280 80

1.81-1 1280 100  1.81-1 1280 100

1.47-101 1280 80  1.47-101 1280 80

1.71-26 1280 100  1.71-26 1280 100

1.71-194 1280 80  1.71-194 1280 80

1.71-5 1280 90  1.71-5 1280 90

1.71-168 1280 80 Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen der Formel (I) bei Behandlung im Nachauflauf eine gute herbizide Wirksamkeit gegen Schadpflanzen auf. Beispielsweise zeigen dabei die in den o.g. Tabellen AI bis AI 4 genannten Verbindungen im Nachauflaufverfahren eine sehr gute herbizide Wirkung (80% bis 100% herbizide Wirkung) gegen Schadpflanzen wie Abutilon theophrasti (ABUTH), Alopecurus myosuroides (ALOMY), Amaranthus retroflexus (AMARE), Cyperus esculentus (CYPES), Digitaria sanguinalis (DIGSA), Echinochloa crus-galli (ECHCG), Hordeum murinum (HORMU), Lolium rigidum (LOLRI), Matricaria inodora (MATIN), Polygonum convolvulus (POLCO), Setaria viridis (SETVI), Stellaria media (STEME), Veronica persica (VERPE) und Viola tricolor (VIOTR), bei einer Aufwandmenge von 1280 g Aktivsubstanz pro Hektar (g/ha) oder weniger. 1.71-168 1280 80 As the results show, compounds of the formula (I) according to the invention have a good herbicidal activity against harmful plants during postemergence treatment. For example, the compounds mentioned in the abovementioned tables AI to AI 4 have a very good herbicidal action (80% to 100% herbicidal action) against harmful plants such as Abutilon theophrasti (ABUTH), Alopecurus myosuroides (ALOMY), Amaranthus retroflexus (AMARE). , Cyperus esculentus (CYPES), Digitaria sanguinalis (DIGSA), Echinochloa crus-galli (ECHCG), Hordeum murinum (HORMU), Lolium rigidum (LOLRI), Matricaria inodora (MATIN), Polygonum convolvulus (POLCO), Setaria viridis (SETVI) , Stellaria media (STEME), Veronica persica (VERPE) and Viola tricolor (VIOTR), at an application rate of 1280 g of active ingredient per hectare (g / ha) or less.

Herbizide Wirkung und Kulturverträglichkeit im Vorauflauf Herbicidal action and culture compatibility in pre-emergence

Samen von mono- bzw. dikotylen Unkraut und Kulturpflanzen wurden in Kunststoff- oder Seeds of monocotyledonous or dicotyledonous weeds and crops were found in plastic or

Holzfasertöpfen ausgelegt und mit Erde abgedeckt. Die in Form von benetzbaren Pulvern (WP) oder als Emulsionskonzentrate (EC) formulierten erfindungsgemäßen Verbindungen wurden dann als wässrige Suspension bzw. Emulsion unter Zusatz von 0,5% Additiv mit einer Wasseraufwandmenge von umgerechnet 600 1/ha auf die Oberfläche der Abdeckerde appliziert. Nach der Behandlung wurden die Töpfe im Gewächshaus aufgestellt und unter guten Wachstumsbedingungen für die Testpflanzen gehalten. Nach ca. 3 Wochen wurde die Wirkung der Präparate visuell im Vergleich zu unbehandelten Kontrollen in Prozentwerten bonitiert. Beispielsweise bedeutet 100% Wirkung = Pflanzen sind abgestorben, 0% Wirkung = wie Kontrollpflanzen. Wood fiber pots designed and covered with soil. The compounds according to the invention formulated as wettable powders (WP) or as emulsion concentrates (EC) were then applied to the surface of the cover soil as an aqueous suspension or emulsion with the addition of 0.5% of additive at a rate of 600 l / ha. After treatment, the pots were placed in the greenhouse and kept under good growth conditions for the test plants. After about 3 weeks, the effect of the preparations was scored visually in comparison to untreated controls in percentages. For example, 100% means action = plants are dead, 0% effect = like control plants.

In den nachstehenden Tabllen Bl bis B13 sind die Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) gemäß der Tabellen LI bis 1.182 auf verschiedene Schadpflanzen und einer Aufwandmenge entsprechend 1280 g/ha und 320 g/ha, die gemäß zuvor genannter Versuchsvorschrift erhalten wurden, dargestellt. In the following Tables Bl to B13, the effects of selected compounds of the general formula (I) according to Tables LI to 1.182 on various harmful plants and an application rate corresponding to 1280 g / ha and 320 g / ha, which were obtained according to the above-mentioned experimental procedure are shown ,

Tabelle Bl : Vorauflaufwirkung gegen Alopecurus myosuroides (ALOMY) Table Bl: Pre-emergence action against Alopecurus myosuroides (ALOMY)

BeispielDosierung example dosage

ALOMY  ALOMY

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-150 320 100  1.71-150 320 100

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 100  1.34-101 320 100

1.72-152 320 100  1.72-152 320 100

1.71-1 320 100 BeispielDosierung 1.71-1 320 100 example dosage

ALOMY  ALOMY

nummer [g/ha] number [g / ha]

1.1-152 320 100 1.1-152 320 100

1.33-101 320 1001.33-101 320 100

1.72-101 320 1001.72-101 320 100

1.73-1 320 1001.73-1 320 100

1.71-211 320 1001.71-211 320 100

1.1-167 320 1001.1-167 320 100

1.34-167 320 1001.34-167 320 100

1.71-167 320 1001.71-167 320 100

1.71-167 320 901.71-167 320 90

1.71-12 320 1001.71-12 320 100

1.71-3 320 1001.71-3 320 100

1.73-167 320 1001.73-167 320 100

1.72-167 320 1001.72-167 320 100

1.72-1 320 1001.72-1 320 100

1.71-14 320 1001.71-14 320 100

1.1-101 320 1001.1-101 320 100

1.47-101 320 1001.47-101 320 100

1.74-101 320 1001.74-101 320 100

1.29-101 320 1001.29-101 320 100

1.71-2 320 1001.71-2 320 100

1.1-1 320 1001.1-1 320 100

1.71-166 320 901.71-166 320 90

1.43-167 320 1001.43-167 320 100

1.1-303 320 1001.1-303 320 100

1.47-167 320 1001.47-167 320 100

1.71-73 320 100.127-167 320 1001.71-73 320 100.127-167 320 100

1.29-1 320 1001.29-1 320 100

1.71-1 320 1001.71-1 320 100

1.72-61 320 1001.72-61 320 100

1.71-152 320 1001.71-152 320 100

1.71-298 320 1001.71-298 320 100

1.71-215 320 1001.71-215 320 100

1.32-167 320 1001.32-167 320 100

1.33-167 320 1001.33-167 320 100

1.71-17 320 1001.71-17 320 100

1.43-1 320 90.129-152 320 901.43-1 320 9029-152 320 90

1.33-152 320 901.33-152 320 90

1.5-101 320 1001.5-101 320 100

1.43-101 320 1001.43-101 320 100

1.43-303 320 1001.43-303 320 100

1.72-194 320 901.72-194 320 90

1.5-152 320 90 BeispielDosierung 1.5-152 320 90 example dosage

ALOMY  ALOMY

nummer [g/ha] number [g / ha]

1.71-296 320 100 1.71-296 320 100

1.71-102 320 90.129-167 320 1001.71-102 320 90.129-167 320 100

1.71-303 320 1001.71-303 320 100

1.71-19 320 1001.71-19 320 100

1.73-303 320 1001.73-303 320 100

1.74-167 320 1001.74-167 320 100

1.71-194 320 100.127-101 320 1001.71-194 320 100.127-101 320 100

1.71-216 320 1001.71-216 320 100

1.75-167 320 1001.75-167 320 100

1.81-1 320 901.81-1 320 90

1.71-26 320 1001.71-26 320 100

1.43-3 320 1001.43-3 320 100

1.72-124 320 1001.72-124 320 100

1.71-227 320 901.71-227 320 90

1.71-16 320 1001.71-16 320 100

1.29-3 320 1001.29-3 320 100

1.74-149 320 901.74-149 320 90

1.71-213 320 1001.71-213 320 100

1.72-59 320 1001.72-59 320 100

1.71-24 320 901.71-24 320 90

1.81-101 320 1001.81-101 320 100

1.71-62 320 901.71-62 320 90

1.71-89 320 901.71-89 320 90

1.71-20 320 901.71-20 320 90

1.71-214 320 1001.71-214 320 100

1.4-101 320 801.4-101 320 80

1.71-110 320 1001.71-110 320 100

1.47-1 320 901.47-1 320 90

1.47-303 320 801.47-303 320 80

1.71-111 320 1001.71-111 320 100

1.74-124 320 901.74-124 320 90

1.71-5 320 1001.71-5 320 100

1.75-101 320 1001.75-101 320 100

1.71-6 320 1001.71-6 320 100

1.71-15 320 1001.71-15 320 100

1.71-197 320 801.71-197 320 80

1.71-193 320 901.71-193 320 90

1.29-171 320 90.144-152 320 901.29-171 320 9044-152 320 90

1.71-85 320 1001.71-85 320 100

1.71-108 320 1001.71-108 320 100

1.1-124 320 90 BeispielDosierung 1.1-124 320 90 example dosage

ALOMY  ALOMY

nummer [g/ha]  number [g / ha]

1.71-63 320 80  1.71-63 320 80

1.71-34 320 80  1.71-34 320 80

1.71-124 320 100  1.71-124 320 100

1.71-37 320 90  1.71-37 320 90

1.71-45 320 80  1.71-45 320 80

1.71-61 320 90  1.71-61 320 90

1.75-1 320 100  1.75-1 320 100

1.71-130 320 100  1.71-130 320 100

1.71-59 320 90  1.71-59 320 90

1.71-139 320 100  1.71-139 320 100

1.71-36 320 90  1.71-36 320 90

1.71-78 320 80  1.71-78 320 80

1.71-74 320 80  1.71-74 320 80

1.71-132 320 80  1.71-132 320 80

1.71-151 320 90  1.71-151 320 90

Tabelle B2: Vorauflaufwirkung gegen Avena fatua (AVEFA) Table B2: Pre-emergence effect against Avena fatua (AVEFA)

BeispielDosierung example dosage

AVEFA  AVEFA

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.71-167 320 90  1.71-167 320 90

1.71-150 320 90  1.71-150 320 90

1.29-167 320 90  1.29-167 320 90

1.71-1 320 100  1.71-1 320 100

1.34-101 320 100  1.34-101 320 100

1.72-152 320 100  1.72-152 320 100

1.71-1 320 100  1.71-1 320 100

1.1-152 320 100  1.1-152 320 100

1.33-101 320 100  1.33-101 320 100

1.72-101 320 80  1.72-101 320 80

1.73-1 320 90  1.73-1 320 90

1.71-211 320 100  1.71-211 320 100

1.1-167 320 90  1.1-167 320 90

1.34-167 320 80  1.34-167 320 80

1.71-167 320 100  1.71-167 320 100

1.71-3 320 90  1.71-3 320 90

1.73-167 320 100  1.73-167 320 100

1.72-167 320 80  1.72-167 320 80

1.72-1 320 100  1.72-1 320 100

1.71-14 320 80  1.71-14 320 80

1.1-101 320 90 BeispielDosierung 1.1-101 320 90 example dosage

AVEFA  AVEFA

nummer [g/ha]  number [g / ha]

1.47-101 320 100  1.47-101 320 100

1.71-2 320 80  1.71-2 320 80

1.1-1 320 90  1.1-1 320 90

1.71-166 320 90  1.71-166 320 90

1.71-73 320 90  1.71-73 320 90

1.29-1 320 90  1.29-1 320 90

1.71-1 320 100  1.71-1 320 100

1.71-152 320 90  1.71-152 320 90

1.71-298 320 80  1.71-298 320 80

1.71-215 320 80  1.71-215 320 80

1.33-167 320 100  1.33-167 320 100

1.71-17 320 90  1.71-17 320 90

1.43-1 320 80  1.43-1 320 80

1.33-152 320 90  1.33-152 320 90

1.5-101 320 100  1.5-101 320 100

1.43-303 320 80  1.43-303 320 80

1.5-152 320 90  1.5-152 320 90

1.71-296 320 80  1.71-296 320 80

1.74-167 320 80  1.74-167 320 80

1.75-167 320 100  1.75-167 320 100

1.71-26 320 80  1.71-26 320 80

Tabelle B3 : Vorauflaufwirkung gegen Cyperus esculentus (CYPES) Table B3: Pre-emergence action against Cyperus esculentus (CYPES)

BeispielDosierung example dosage

CYPES  CYPES

nummer [g/ha]  number [g / ha]

1.71-167 320 100  1.71-167 320 100

1.71-150 320 100  1.71-150 320 100

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.72-152 320 100  1.72-152 320 100

1.1-152 320 100  1.1-152 320 100

1.33-101 320 100  1.33-101 320 100

1.72-101 320 100  1.72-101 320 100

1.73-1 320 100  1.73-1 320 100

1.1-167 320 100  1.1-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-12 320 100  1.71-12 320 100

1.71-3 320 100  1.71-3 320 100

1.73-167 320 100  1.73-167 320 100

1.72-167 320 100 BeispielDosierung 1.72-167 320 100 example dosage

CYPES  CYPES

nummer [g/ha] number [g / ha]

1.72-1 320 100 1.72-1 320 100

1.71-14 320 1001.71-14 320 100

1.1-101 320 1001.1-101 320 100

1.47-101 320 1001.47-101 320 100

1.74-101 320 801.74-101 320 80

1.29-101 320 1001.29-101 320 100

1.71-2 320 1001.71-2 320 100

1.1-1 320 1001.1-1 320 100

1.71-166 320 1001.71-166 320 100

1.43-167 320 1001.43-167 320 100

1.1-303 320 1001.1-303 320 100

1.47-167 320 1001.47-167 320 100

1.71-73 320 901.71-73 320 90

1.29-1 320 1001.29-1 320 100

1.72-61 320 901.72-61 320 90

1.71-152 320 1001.71-152 320 100

1.29-214 320 1001.29-214 320 100

1.71-215 320 801.71-215 320 80

1.32-167 320 1001.32-167 320 100

1.33-167 320 1001.33-167 320 100

1.71-17 320 1001.71-17 320 100

1.43-1 320 1001.43-1 320 100

1.33-152 320 1001.33-152 320 100

1.5-101 320 901.5-101 320 90

1.43-101 320 901.43-101 320 90

1.43-303 320 1001.43-303 320 100

1.72-194 320 1001.72-194 320 100

1.5-152 320 901.5-152 320 90

1.71-102 320 901.71-102 320 90

1.71-27 320 1001.71-27 320 100

1.71-303 320 1001.71-303 320 100

1.71-19 320 1001.71-19 320 100

1.73-303 320 1001.73-303 320 100

1.74-167 320 1001.74-167 320 100

1.71-194 320 1001.71-194 320 100

1.71-216 320 1001.71-216 320 100

1.75-167 320 1001.75-167 320 100

1.81-1 320 901.81-1 320 90

1.71-26 320 1001.71-26 320 100

1.43-3 320 1001.43-3 320 100

1.72-124 320 1001.72-124 320 100

1.71-227 320 1001.71-227 320 100

1.71-16 320 1001.71-16 320 100

1.29-3 320 100 BeispielDosierung 1.29-3 320 100 example dosage

CYPES  CYPES

nummer [g/ha] number [g / ha]

1.74-149 320 100 1.74-149 320 100

1.71-213 320 1001.71-213 320 100

1.71-24 320 901.71-24 320 90

1.81-101 320 901.81-101 320 90

1.71-89 320 801.71-89 320 80

1.71-20 320 901.71-20 320 90

1.71-214 320 1001.71-214 320 100

1.4-101 320 1001.4-101 320 100

1.47-1 320 1001.47-1 320 100

1.47-303 320 1001.47-303 320 100

1.71-111 320 801.71-111 320 80

1.74-124 320 1001.74-124 320 100

1.71-5 320 1001.71-5 320 100

1.75-101 320 1001.75-101 320 100

1.71-6 320 1001.71-6 320 100

1.71-197 320 1001.71-197 320 100

1.71-193 320 1001.71-193 320 100

1.71-85 320 1001.71-85 320 100

1.81-167 320 1001.81-167 320 100

1.71-149 320 1001.71-149 320 100

1.5-1 320 801.5-1 320 80

1.75-1 320 901.75-1 320 90

1.71-139 320 801.71-139 320 80

1.71-228 320 1001.71-228 320 100

1.4-167 320 801.4-167 320 80

1.4-1 320 1001.4-1 320 100

1.71-78 320 1001.71-78 320 100

1.75-213 320 801.75-213 320 80

1.1-171 320 801.1-171 320 80

1.71-38 320 1001.71-38 320 100

1.71-56 320 801.71-56 320 80

1.43-192 320 801.43-192 320 80

1.43-213 320 801.43-213 320 80

1.71-222 320 901.71-222 320 90

1.5-171 320 100 Tabelle B4: Vorauflauiwirkung gegen Digitaria sanguinalis (DIGSA) 1.5-171 320 100 Table B4: Pre-emergence action against Digitaria sanguinalis (DIGSA)

BeispielDosierung example dosage

DIGSA  DIGSA

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.34-101 320 100  1.34-101 320 100

1.71-1 320 100  1.71-1 320 100

1.71-211 320 100  1.71-211 320 100

1.34-167 320 100  1.34-167 320 100

1.127-167 320 100  1,127-167,320,100

1.71-1 320 100  1.71-1 320 100

1.71-298 320 100  1.71-298 320 100

1.129-152 320 100  1.129-152 320 100

1.71-296 320 100  1.71-296 320 100

1.129-167 320 100  1,129-167,320,100

1.127-101 320 100  1,127-101 320,100

1.144-152 320 100  1,144-152,320,100

1.144-167 320 100  1,144-167,320,100

Tabelle B5: Vorauflauiwirkung gegen Echinochloa crus-galli (ECHCG) Table B5: Pre-emergence activity against Echinochloa crus-galli (ECHCG)

BeispielDosierung example dosage

ECHCG  ECHCG

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-150 320 100  1.71-150 320 100

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 100  1.34-101 320 100

1.72-152 320 100  1.72-152 320 100

1.71-1 320 100  1.71-1 320 100

1.1-152 320 100  1.1-152 320 100

1.33-101 320 100  1.33-101 320 100

1.72-101 320 100  1.72-101 320 100

1.73-1 320 100  1.73-1 320 100

1.71-211 320 100  1.71-211 320 100

1.1-167 320 100  1.1-167 320 100

1.34-167 320 100  1.34-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-12 320 100  1.71-12 320 100

1.71-3 320 100  1.71-3 320 100

1.73-167 320 100  1.73-167 320 100

1.72-167 320 100  1.72-167 320 100

1.72-1 320 100 BeispielDosierung 1.72-1 320 100 example dosage

ECHCG  ECHCG

nummer [g/ha] number [g / ha]

1.71-14 320 100 1.71-14 320 100

1.1-101 320 1001.1-101 320 100

1.47-101 320 1001.47-101 320 100

1.74-101 320 1001.74-101 320 100

1.29-101 320 1001.29-101 320 100

1.71-2 320 1001.71-2 320 100

1.1-1 320 1001.1-1 320 100

1.71-166 320 1001.71-166 320 100

1.43-167 320 1001.43-167 320 100

1.1-303 320 1001.1-303 320 100

1.47-167 320 1001.47-167 320 100

1.71-73 320 100.127-167 320 1001.71-73 320 100.127-167 320 100

1.29-1 320 1001.29-1 320 100

1.71-1 320 1001.71-1 320 100

1.72-61 320 1001.72-61 320 100

1.71-152 320 1001.71-152 320 100

1.71-298 320 1001.71-298 320 100

1.29-214 320 1001.29-214 320 100

1.71-215 320 901.71-215 320 90

1.32-167 320 1001.32-167 320 100

1.33-167 320 1001.33-167 320 100

1.71-17 320 1001.71-17 320 100

1.43-1 320 100.129-152 320 1001.43-1 320 100.129-152 320 100

1.33-152 320 1001.33-152 320 100

1.5-101 320 1001.5-101 320 100

1.43-101 320 1001.43-101 320 100

1.43-303 320 1001.43-303 320 100

1.72-194 320 1001.72-194 320 100

1.5-152 320 1001.5-152 320 100

1.71-296 320 1001.71-296 320 100

1.71-102 320 100.129-167 320 1001.71-102 320 100.129-167 320 100

1.71-27 320 1001.71-27 320 100

1.71-303 320 1001.71-303 320 100

1.71-19 320 1001.71-19 320 100

1.73-303 320 1001.73-303 320 100

1.74-167 320 901.74-167 320 90

1.71-194 320 100.127-101 320 1001.71-194 320 100.127-101 320 100

1.71-216 320 1001.71-216 320 100

1.75-167 320 1001.75-167 320 100

1.81-1 320 100 BeispielDosierung 1.81-1 320 100 example dosage

ECHCG  ECHCG

nummer [g/ha] number [g / ha]

1.71-26 320 100 1.71-26 320 100

1.43-3 320 1001.43-3 320 100

1.72-124 320 1001.72-124 320 100

1.71-227 320 801.71-227 320 80

1.71-16 320 1001.71-16 320 100

1.29-3 320 1001.29-3 320 100

1.74-149 320 1001.74-149 320 100

1.71-213 320 1001.71-213 320 100

1.72-59 320 1001.72-59 320 100

1.71-24 320 801.71-24 320 80

1.81-101 320 1001.81-101 320 100

1.71-62 320 1001.71-62 320 100

1.71-89 320 1001.71-89 320 100

1.71-20 320 1001.71-20 320 100

1.71-214 320 1001.71-214 320 100

1.4-101 320 1001.4-101 320 100

1.71-110 320 1001.71-110 320 100

1.47-1 320 1001.47-1 320 100

1.47-303 320 1001.47-303 320 100

1.71-111 320 1001.71-111 320 100

1.74-124 320 1001.74-124 320 100

1.71-5 320 1001.71-5 320 100

1.75-101 320 1001.75-101 320 100

1.71-6 320 1001.71-6 320 100

1.71-15 320 1001.71-15 320 100

1.71-197 320 801.71-197 320 80

1.71-193 320 901.71-193 320 90

1.29-171 320 100.144-152 320 1001.29-171 320 100.144-152 320 100

1.71-85 320 1001.71-85 320 100

1.71-108 320 1001.71-108 320 100

1.81-167 320 1001.81-167 320 100

1.1-124 320 1001.1-124 320 100

1.71-149 320 901.71-149 320 90

1.74-1 320 1001.74-1 320 100

1.5-1 320 1001.5-1 320 100

1.71-63 320 1001.71-63 320 100

1.71-34 320 901.71-34 320 90

1.71-168 320 1001.71-168 320 100

1.29-213 320 901.29-213 320 90

1.71-124 320 1001.71-124 320 100

1.71-37 320 1001.71-37 320 100

1.71-61 320 1001.71-61 320 100

1.75-1 320 90 BeispielDosierung 1.75-1 320 90 example dosage

ECHCG  ECHCG

nummer [g/ha]  number [g / ha]

1.71-130 320 100  1.71-130 320 100

1.71-59 320 100  1.71-59 320 100

1.71-139 320 100  1.71-139 320 100

1.71-228 320 100  1.71-228 320 100

1.4-167 320 100  1.4-167 320 100

1.4-1 320 100  1.4-1 320 100

1.71-74 320 100  1.71-74 320 100

1.71-132 320 80  1.71-132 320 80

1.144-167 320 100  1,144-167,320,100

1.71-151 320 100  1.71-151 320 100

1.144-137 320 100  1,144-137,320,100

1.71-157 320 80  1.71-157 320 80

1.43-214 320 100  1.43-214 320 100

Tabelle B6: Vorauflaufwirkung gegen Lolium rigidum (LOLRI) Table B6: Pre-emergence action against Lolium rigidum (LOLRI)

BeispielDosierung example dosage

LOLRI  LOLRI

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-150 320 100  1.71-150 320 100

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 100  1.34-101 320 100

1.72-152 320 100  1.72-152 320 100

1.71-1 320 100  1.71-1 320 100

1.1-152 320 100  1.1-152 320 100

1.33-101 320 100  1.33-101 320 100

1.72-101 320 100  1.72-101 320 100

1.73-1 320 100  1.73-1 320 100

1.71-211 320 100  1.71-211 320 100

1.1-167 320 100  1.1-167 320 100

1.34-167 320 100  1.34-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-12 320 100  1.71-12 320 100

1.71-3 320 100  1.71-3 320 100

1.73-167 320 100  1.73-167 320 100

1.72-167 320 100  1.72-167 320 100

1.72-1 320 100  1.72-1 320 100

1.71-14 320 100  1.71-14 320 100

1.1-101 320 100  1.1-101 320 100

1.47-101 320 100 BeispielDosierung 1.47-101 320 100 example dosage

LOLRI  LOLRI

nummer [g/ha] number [g / ha]

1.74-101 320 100 1.74-101 320 100

1.29-101 320 1001.29-101 320 100

1.71-2 320 1001.71-2 320 100

1.1-1 320 1001.1-1 320 100

1.71-166 320 1001.71-166 320 100

1.43-167 320 1001.43-167 320 100

1.1-303 320 1001.1-303 320 100

1.47-167 320 1001.47-167 320 100

1.71-73 320 100.127-167 320 1001.71-73 320 100.127-167 320 100

1.29-1 320 1001.29-1 320 100

1.71-1 320 1001.71-1 320 100

1.72-61 320 901.72-61 320 90

1.71-152 320 1001.71-152 320 100

1.71-298 320 1001.71-298 320 100

1.71-215 320 901.71-215 320 90

1.32-167 320 1001.32-167 320 100

1.33-167 320 1001.33-167 320 100

1.71-17 320 1001.71-17 320 100

1.43-1 320 100.129-152 320 801.43-1 320 100.129-152 320 80

1.5-101 320 1001.5-101 320 100

1.43-303 320 1001.43-303 320 100

1.72-194 320 1001.72-194 320 100

1.5-152 320 1001.5-152 320 100

1.71-296 320 1001.71-296 320 100

1.71-102 320 90.129-167 320 1001.71-102 320 90.129-167 320 100

1.71-27 320 901.71-27 320 90

1.71-303 320 1001.71-303 320 100

1.71-19 320 1001.71-19 320 100

1.73-303 320 1001.73-303 320 100

1.74-167 320 801.74-167 320 80

1.71-194 320 90.127-101 320 1001.71-194 320 90.127-101 320 100

1.71-216 320 1001.71-216 320 100

1.75-167 320 1001.75-167 320 100

1.81-1 320 1001.81-1 320 100

1.71-26 320 1001.71-26 320 100

1.43-3 320 901.43-3 320 90

1.72-124 320 1001.72-124 320 100

1.71-227 320 901.71-227 320 90

1.71-16 320 1001.71-16 320 100

1.29-3 320 90 BeispielDosierung 1.29-3 320 90 example dosage

LOLRI  LOLRI

nummer [g/ha]  number [g / ha]

1.71-213 320 90  1.71-213 320 90

1.72-59 320 100  1.72-59 320 100

1.71-24 320 100  1.71-24 320 100

1.81-101 320 100  1.81-101 320 100

1.71-89 320 100  1.71-89 320 100

1.71-20 320 90  1.71-20 320 90

1.71-110 320 100  1.71-110 320 100

1.47-1 320 100  1.47-1 320 100

1.47-303 320 100  1.47-303 320 100

1.71-111 320 100  1.71-111 320 100

1.74-124 320 80  1.74-124 320 80

1.71-5 320 90  1.71-5 320 90

1.71-6 320 100  1.71-6 320 100

1.71-15 320 100  1.71-15 320 100

1.71-193 320 80  1.71-193 320 80

1.29-171 320 90  1.29-171 320 90

1.144-152 320 100  1,144-152,320,100

1.71-85 320 100  1.71-85 320 100

1.71-108 320 80  1.71-108 320 80

1.1-124 320 90  1.1-124 320 90

1.5-1 320 80  1.5-1 320 80

1.71-124 320 100  1.71-124 320 100

1.71-59 320 90  1.71-59 320 90

1.71-228 320 100  1.71-228 320 100

1.71-36 320 80  1.71-36 320 80

Tabelle B7: Vorauflaufwirkung gegen Setaria viridis (SETVI) Table B7: Pre-emergence action against Setaria viridis (SETVI)

BeispielDosierung example dosage

SETVI  SETVI

nummer [g/ha]  number [g / ha]

1.6-167 320 100  1.6-167 320 100

1.71-167 320 100  1.71-167 320 100

1.71-150 320 100  1.71-150 320 100

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 100  1.34-101 320 100

1.72-152 320 100  1.72-152 320 100

1.71-1 320 100  1.71-1 320 100

1.1-152 320 100  1.1-152 320 100

1.33-101 320 100  1.33-101 320 100

1.72-101 320 100  1.72-101 320 100

1.73-1 320 100 BeispielDosierung 1.73-1 320 100 example dosage

SETVI  SETVI

nummer [g/ha] number [g / ha]

1.71-211 320 100 1.71-211 320 100

1.1-167 320 1001.1-167 320 100

1.34-167 320 1001.34-167 320 100

1.71-167 320 1001.71-167 320 100

1.71-167 320 1001.71-167 320 100

1.71-12 320 1001.71-12 320 100

1.71-3 320 1001.71-3 320 100

1.73-167 320 1001.73-167 320 100

1.72-167 320 1001.72-167 320 100

1.72-1 320 1001.72-1 320 100

1.71-14 320 1001.71-14 320 100

1.1-101 320 1001.1-101 320 100

1.47-101 320 1001.47-101 320 100

1.74-101 320 1001.74-101 320 100

1.29-101 320 1001.29-101 320 100

1.71-2 320 1001.71-2 320 100

1.1-1 320 1001.1-1 320 100

1.71-166 320 1001.71-166 320 100

1.43-167 320 1001.43-167 320 100

1.1-303 320 1001.1-303 320 100

1.47-167 320 1001.47-167 320 100

1.71-73 320 100.127-167 320 1001.71-73 320 100.127-167 320 100

1.29-1 320 1001.29-1 320 100

1.71-1 320 1001.71-1 320 100

1.72-61 320 1001.72-61 320 100

1.71-152 320 1001.71-152 320 100

1.71-298 320 1001.71-298 320 100

1.29-214 320 1001.29-214 320 100

1.71-215 320 1001.71-215 320 100

1.32-167 320 1001.32-167 320 100

1.33-167 320 1001.33-167 320 100

1.71-17 320 1001.71-17 320 100

1.43-1 320 100.129-152 320 1001.43-1 320 100.129-152 320 100

1.33-152 320 1001.33-152 320 100

1.5-101 320 1001.5-101 320 100

1.43-101 320 1001.43-101 320 100

1.43-303 320 1001.43-303 320 100

1.72-194 320 1001.72-194 320 100

1.5-152 320 1001.5-152 320 100

1.71-296 320 1001.71-296 320 100

1.71-102 320 100.129-167 320 100 BeispielDosierung 1.71-102 320 100.129-167 320 100 example dosage

SETVI  SETVI

nummer [g/ha] number [g / ha]

1.71-27 320 100 1.71-27 320 100

1.71-303 320 1001.71-303 320 100

1.71-19 320 1001.71-19 320 100

1.73-303 320 1001.73-303 320 100

1.74-167 320 901.74-167 320 90

1.71-194 320 100.127-101 320 1001.71-194 320 100.127-101 320 100

1.71-216 320 1001.71-216 320 100

1.75-167 320 1001.75-167 320 100

1.71-26 320 1001.71-26 320 100

1.43-3 320 1001.43-3 320 100

1.72-124 320 1001.72-124 320 100

1.71-227 320 1001.71-227 320 100

1.71-16 320 1001.71-16 320 100

1.29-3 320 1001.29-3 320 100

1.74-149 320 801.74-149 320 80

1.71-213 320 1001.71-213 320 100

1.72-59 320 1001.72-59 320 100

1.71-24 320 1001.71-24 320 100

1.81-101 320 1001.81-101 320 100

1.71-62 320 1001.71-62 320 100

1.71-89 320 1001.71-89 320 100

1.71-20 320 1001.71-20 320 100

1.71-214 320 1001.71-214 320 100

1.4-101 320 1001.4-101 320 100

1.71-110 320 1001.71-110 320 100

1.47-1 320 1001.47-1 320 100

1.47-303 320 1001.47-303 320 100

1.71-111 320 1001.71-111 320 100

1.74-124 320 1001.74-124 320 100

1.71-5 320 1001.71-5 320 100

1.75-101 320 1001.75-101 320 100

1.71-6 320 1001.71-6 320 100

1.71-15 320 1001.71-15 320 100

1.71-197 320 1001.71-197 320 100

1.71-193 320 1001.71-193 320 100

1.29-171 320 100.144-152 320 1001.29-171 320 100.144-152 320 100

1.71-108 320 1001.71-108 320 100

1.81-167 320 1001.81-167 320 100

1.1-124 320 1001.1-124 320 100

1.71-149 320 801.71-149 320 80

1.74-1 320 1001.74-1 320 100

1.5-1 320 100 BeispielDosierung 1.5-1 320 100 example dosage

SETVI  SETVI

nummer [g/ha] number [g / ha]

1.71-63 320 100 1.71-63 320 100

1.71-34 320 1001.71-34 320 100

1.71-168 320 1001.71-168 320 100

1.29-213 320 1001.29-213 320 100

1.71-124 320 1001.71-124 320 100

1.71-37 320 1001.71-37 320 100

1.71-45 320 901.71-45 320 90

1.71-61 320 1001.71-61 320 100

1.75-1 320 801.75-1 320 80

1.71-130 320 1001.71-130 320 100

1.71-59 320 1001.71-59 320 100

1.71-139 320 901.71-139 320 90

1.71-228 320 1001.71-228 320 100

1.4-167 320 1001.4-167 320 100

1.4-1 320 1001.4-1 320 100

1.71-36 320 1001.71-36 320 100

1.71-78 320 1001.71-78 320 100

1.71-144 320 801.71-144 320 80

1.71-74 320 1001.71-74 320 100

1.75-213 320 1001.75-213 320 100

1.71-132 320 100.144-167 320 1001.71-132 320 100.144-167 320 100

1.71-151 320 1001.71-151 320 100

1.71-79 320 100.144-137 320 1001.71-79 320 100.144-137 320 100

1.71-157 320 1001.71-157 320 100

1.1-213 320 901.1-213 320 90

1.71-38 320 1001.71-38 320 100

1.71-56 320 801.71-56 320 80

1.43-192 320 801.43-192 320 80

1.29-4 320 901.29-4 320 90

1.43-213 320 801.43-213 320 80

1.43-214 320 1001.43-214 320 100

1.84-101 320 801.84-101 320 80

1.71-222 320 901.71-222 320 90

1.71-143 320 1001.71-143 320 100

1.71-25 320 1001.71-25 320 100

1.71-171 320 801.71-171 320 80

1.71-77 320 901.71-77 320 90

1.1-3 320 90 Tabelle B8: Vorauflauiwirkung gegen Abutilon theophrasti (ABUTH) 1.1-3 320 90 Table B8: Pre-Exposure to Abutilon theophrasti (ABUTH)

Figure imgf000271_0001
Figure imgf000271_0001

Tabelle B9: Vorauflauiwirkung gegen Amaranthus retroflexus (AMARE) Table B9: Pre-emergence activity against Amaranthus retroflexus (AMARE)

BeispielDosierung example dosage

AMARE  AMARE

nummer [g/ha]  number [g / ha]

1.6-167 320 80  1.6-167 320 80

1.71-167 320 90  1.71-167 320 90

1.71-150 320 80  1.71-150 320 80

1.29-167 320 100  1.29-167 320 100

1.71-1 320 80  1.71-1 320 80

1.34-101 320 90  1.34-101 320 90

1.72-152 320 90 BeispielDosierung 1.72-152 320 90 example dosage

AMARE  AMARE

nummer [g/ha]  number [g / ha]

1.71-1 320 90  1.71-1 320 90

1.33-101 320 90  1.33-101 320 90

1.72-101 320 90  1.72-101 320 90

1.73-1 320 80  1.73-1 320 80

1.71-211 320 90  1.71-211 320 90

1.1-167 320 80  1.1-167 320 80

1.34-167 320 90  1.34-167 320 90

1.71-167 320 80  1.71-167 320 80

1.71-167 320 80  1.71-167 320 80

1.71-12 320 80  1.71-12 320 80

1.71-3 320 90  1.71-3 320 90

1.73-167 320 80  1.73-167 320 80

1.72-167 320 90  1.72-167 320 90

1.72-1 320 90  1.72-1 320 90

1.71-14 320 80  1.71-14 320 80

1.1-101 320  1.1-101 320

1.47-101 320 90  1.47-101 320 90

1.29-101 320 90  1.29-101 320 90

1.1-1 320 80  1.1-1 320 80

1.71-166 320 90  1.71-166 320 90

1.1-303 320 80  1.1-303 320 80

1.47-167 320 100  1.47-167 320 100

1.127-167 320 90  1.127-167 320 90

1.32-167 320 100  1.32-167 320 100

1.5-101 320 80  1.5-101 320 80

1.74-149 320 90  1.74-149 320 90

Tabelle BIO: Vorauflaufwirkung gegen gonum convolvulus (POLCO) Table BIO: Pre-emergence effect against gonum convolvulus (POLCO)

BeispielDosierung example dosage

POLCO  POLCO

nummer [g/ha]  number [g / ha]

1.6-167 320 90  1.6-167 320 90

1.71-167 320 90  1.71-167 320 90

1.71-150 320 80  1.71-150 320 80

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 90  1.34-101 320 90

1.72-152 320 80  1.72-152 320 80

1.71-1 320 90  1.71-1 320 90

1.1-152 320 80  1.1-152 320 80

1.33-101 320 90  1.33-101 320 90

1.72-101 320 100  1.72-101 320 100

1.73-1 320 80 BeispielDosierung 1.73-1 320 80 example dosage

POLCO  POLCO

nummer [g/ha]  number [g / ha]

1.71-211 320 90  1.71-211 320 90

1.34-167 320 90  1.34-167 320 90

1.71-167 320 100  1.71-167 320 100

1.71-12 320 90  1.71-12 320 90

1.71-3 320 80  1.71-3 320 80

1.73-167 320 90  1.73-167 320 90

1.72-167 320 90  1.72-167 320 90

1.72-1 320 80  1.72-1 320 80

1.71-14 320 80  1.71-14 320 80

1.47-101 320 100  1.47-101 320 100

1.74-101 320 100  1.74-101 320 100

1.71-2 320 90  1.71-2 320 90

1.71-166 320 100  1.71-166 320 100

1.47-167 320 100  1.47-167 320 100

1.127-167 320 90  1.127-167 320 90

1.72-61 320 90  1.72-61 320 90

1.71-298 320 80  1.71-298 320 80

1.29-214 320 80  1.29-214 320 80

1.32-167 320 90  1.32-167 320 90

1.33-167 320 90  1.33-167 320 90

1.129-152 320 100  1.129-152 320 100

1.5-152 320 80  1.5-152 320 80

1.129-167 320 100  1,129-167,320,100

1.71-27 320 80  1.71-27 320 80

1.73-303 320 80  1.73-303 320 80

1.74-149 320 90  1.74-149 320 90

1.71-213 320 90  1.71-213 320 90

1.71-62 320 80  1.71-62 320 80

1.71-130 320 90  1.71-130 320 90

1.1-213 320 80  1.1-213 320 80

1.71-55 320 80  1.71-55 320 80

Tabelle Bl 1 : Vorauflauiwirkung gegen Viola tricolor (VIOTR) Table B1: Vorauflauiwirkung Viola tricolor (VIOTR)

BeispielDosierung example dosage

VIOTR  VIOTR

nummer [g/ha]  number [g / ha]

1.6-167 320 90  1.6-167 320 90

1.71-167 320 80  1.71-167 320 80

1.71-150 320 80  1.71-150 320 80

1.29-167 320 100  1.29-167 320 100

1.71-1 320 100  1.71-1 320 100

1.34-101 320 90  1.34-101 320 90

1.72-152 320 80 BeispielDosierung 1.72-152 320 80 example dosage

VIOTR  VIOTR

nummer [g/ha]  number [g / ha]

1.71-1 320 80  1.71-1 320 80

1.1-152 320 80  1.1-152 320 80

1.33-101 320 80  1.33-101 320 80

1.72-101 320 80  1.72-101 320 80

1.73-1 320 80  1.73-1 320 80

1.1-167 320 80  1.1-167 320 80

1.34-167 320 90  1.34-167 320 90

1.71-167 320 90  1.71-167 320 90

1.73-167 320 80  1.73-167 320 80

1.71-14 320 80  1.71-14 320 80

1.1-101 320 80  1.1-101 320 80

1.47-101 320 90  1.47-101 320 90

1.29-101 320 80  1.29-101 320 80

1.43-167 320 80  1.43-167 320 80

1.1-303 320 80  1.1-303 320 80

1.72-61 320 100  1.72-61 320 100

1.29-214 320 80  1.29-214 320 80

1.129-152 320 100  1.129-152 320 100

1.43-101 320 80  1.43-101 320 80

1.72-194 320 80  1.72-194 320 80

1.71-102 320 80  1.71-102 320 80

1.129-167 320 90  1.129-167 320 90

1.71-303 320 90  1.71-303 320 90

1.74-167 320 80  1.74-167 320 80

1.71-194 320 80  1.71-194 320 80

1.72-59 320 80  1.72-59 320 80

1.71-24 320 80  1.71-24 320 80

1.4-101 320 100  1.4-101 320 100

Tabelle B12: Vorauflaufwirkung gegen Veronica persica (VERPE) Table B12: Pre-emergence action against Veronica persica (VERPE)

BeispielDosierung example dosage

VERPE  VERPE

nummer [g/ha]  number [g / ha]

1.6-167 320 90  1.6-167 320 90

1.71-167 320 90  1.71-167 320 90

1.71-150 320 90  1.71-150 320 90

1.29-167 320 90  1.29-167 320 90

1.71-1 320 80  1.71-1 320 80

1.34-101 320 90  1.34-101 320 90

1.72-152 320 90  1.72-152 320 90

1.71-1 320 90  1.71-1 320 90

1.1-152 320 80  1.1-152 320 80

1.33-101 320 80 BeispielDosierung 1.33-101 320 80 example dosage

VERPE  VERPE

nummer [g/ha] number [g / ha]

1.72-101 320 100 1.72-101 320 100

1.73-1 320 901.73-1 320 90

1.71-211 320 901.71-211 320 90

1.1-167 320 1001.1-167 320 100

1.34-167 320 1001.34-167 320 100

1.71-167 320 801.71-167 320 80

1.71-167 320 901.71-167 320 90

1.71-12 320 901.71-12 320 90

1.71-3 320 1001.71-3 320 100

1.72-167 320 1001.72-167 320 100

1.72-1 320 1001.72-1 320 100

1.71-14 320 801.71-14 320 80

1.1-101 320 801.1-101 320 80

1.74-101 320 801.74-101 320 80

1.71-2 320 801.71-2 320 80

1.1-1 320 801.1-1 320 80

1.71-166 320 1001.71-166 320 100

1.43-167 320 801.43-167 320 80

1.1-303 320 901.1-303 320 90

1.47-167 320 801.47-167 320 80

1.71-73 320 80.127-167 320 901.71-73 320 80.127-167 320 90

1.29-1 320 1001.29-1 320 100

1.71-1 320 901.71-1 320 90

1.72-61 320 901.72-61 320 90

1.71-152 320 801.71-152 320 80

1.71-298 320 901.71-298 320 90

1.29-214 320 901.29-214 320 90

1.71-215 320 901.71-215 320 90

1.32-167 320 801.32-167 320 80

1.33-167 320 801.33-167 320 80

1.71-17 320 1001.71-17 320 100

1.43-1 320 901.43-1 320 90

1.33-152 320 901.33-152 320 90

1.43-101 320 901.43-101 320 90

1.43-303 320 901.43-303 320 90

1.71-296 320 801.71-296 320 80

1.71-102 320 80.129-167 320 801.71-102 320 80.129-167 320 80

1.71-27 320 901.71-27 320 90

1.71-303 320 801.71-303 320 80

1.71-19 320 801.71-19 320 80

1.73-303 320 801.73-303 320 80

1.71-194 320 80 BeispielDosierung 1.71-194 320 80 example dosage

VERPE  VERPE

nummer [g/ha]  number [g / ha]

1.127-101 320 90  1.127-101 320 90

1.71-216 320 80  1.71-216 320 80

1.75-167 320 80  1.75-167 320 80

1.81-1 320 80  1.81-1 320 80

1.43-3 320 80  1.43-3 320 80

1.72-124 320 80  1.72-124 320 80

1.71-16 320 90  1.71-16 320 90

1.72-59 320 100  1.72-59 320 100

1.71-24 320 80  1.71-24 320 80

1.71-62 320 90  1.71-62 320 90

1.71-89 320 100  1.71-89 320 100

1.71-110 320 100  1.71-110 320 100

1.47-303 320 90  1.47-303 320 90

1.71-111 320 80  1.71-111 320 80

1.74-124 320 90  1.74-124 320 90

1.71-6 320 100  1.71-6 320 100

1.71-15 320 80  1.71-15 320 80

1.71-85 320 80  1.71-85 320 80

1.71-108 320 100  1.71-108 320 100

1.81-167 320 80  1.81-167 320 80

1.71-63 320 80  1.71-63 320 80

1.71-34 320 80  1.71-34 320 80

1.71-168 320 80  1.71-168 320 80

1.29-213 320 80  1.29-213 320 80

1.71-37 320 80  1.71-37 320 80

1.71-61 320 80  1.71-61 320 80

1.71-144 320 80  1.71-144 320 80

1.71-79 320 90  1.71-79 320 90

1.71-153 320 80  1.71-153 320 80

Tabelle B13: Vorauflaufwirkung gegen Hordeum murinum (HORMU) Table B13: Pre-emergence activity against Hordeum murinum (HORMU)

BeispielDosierung example dosage

HORMU  Hormu

nummer [g/ha]  number [g / ha]

1.71-167 1280 100  1.71-167 1280 100

1.71-150 1280 100  1.71-150 1280 100

1.1-122 1280 80  1.1-122 1280 80

1.74-101 1280 100  1.74-101 1280 100

1.73-1 1280 100  1.73-1 1280 100

1.5-101 1280 100  1.5-101 1280 100

1.5-1 1280 80  1.5-1 1280 80

1.4-167 1280 100 BeispielDosierung 1.4-167 1280 100 example dosage

HORMU  Hormu

nummer [g/ha] number [g / ha]

1.4-101 1280 100 1.4-101 1280 100

1.1-149 1280 1001.1-149 1280 100

1.47-101 1280 1001.47-101 1280 100

1.47-1 1280 1001.47-1 1280 100

1.47-303 1280 1001.47-303 1280 100

1.32-167 1280 1001.32-167 1280 100

1.33-167 1280 1001.33-167 1280 100

1.33-101 1280 1001.33-101 1280 100

1.71-27 1280 1001.71-27 1280 100

1.71-168 1280 1001.71-168 1280 100

1.81-167 1280 901.81-167 1280 90

1.81-101 1280 1001.81-101 1280 100

1.81-1 1280 1001.81-1 1280 100

1.71-26 1280 1001.71-26 1280 100

1.71-36 1280 1001.71-36 1280 100

1.71-152 1280 1001.71-152 1280 100

1.71-124 1280 1001.71-124 1280 100

1.71-46 1280 1001.71-46 1280 100

1.71-144 1280 1001.71-144 1280 100

1.71-55 1280 801.71-55 1280 80

1.71-85 1280 1001.71-85 1280 100

1.71-56 1280 1001.71-56 1280 100

1.71-20 1280 1001.71-20 1280 100

1.71-45 1280 1001.71-45 1280 100

1.71-130 1280 1001.71-130 1280 100

1.71-132 1280 801.71-132 1280 80

1.71-193 1280 1001.71-193 1280 100

1.71-222 1280 1001.71-222 1280 100

1.72-101 1280 1001.72-101 1280 100

1.71-14 1280 1001.71-14 1280 100

1.71-15 1280 1001.71-15 1280 100

1.71-19 1280 1001.71-19 1280 100

1.73-303 1280 1001.73-303 1280 100

1.71-227 1280 1001.71-227 1280 100

1.71-38 1280 1001.71-38 1280 100

1.71-37 1280 1001.71-37 1280 100

1.71-102 1280 1001.71-102 1280 100

1.71-194 1280 1001.71-194 1280 100

1.71-73 1280 1001.71-73 1280 100

1.71-78 1280 801.71-78 1280 80

1.71-77 1280 901.71-77 1280 90

1.71-24 1280 1001.71-24 1280 100

1.43-192 1280 90 BeispielDosierung 1.43-192 1280 90 example dosage

HORMU  Hormu

nummer [g/ha]  number [g / ha]

1.29-171 1280 100  1.29-171 1280 100

1.29-4 1280 100  1.29-4 1280 100

1.29-213 1280 100  1.29-213 1280 100

1.29-214 1280 100  1.29-214 1280 100

1.43-213 1280 90  1.43-213 1280 90

1.75-101 1280 100  1.75-101 1280 100

1.75-1 1280 100  1.75-1 1280 100

1.75-213 1280 90  1.75-213 1280 90

1.74-149 1280 100  1.74-149 1280 100

1.84-101 1280 80  1.84-101 1280 80

1.71-303 1280 100  1.71-303 1280 100

1.71-197 1280 100  1.71-197 1280 100

1.71-5 1280 100  1.71-5 1280 100

1.71-151 1280 100  1.71-151 1280 100

1.72-61 1280 90  1.72-61 1280 90

1.71-76 1280 90  1.71-76 1280 90

1.71-139 1280 100  1.71-139 1280 100

1.72-167 1280 100  1.72-167 1280 100

1.1-124 1280 100  1.1-124 1280 100

1.1-171 1280 100  1.1-171 1280 100

1.1-213 1280 100  1.1-213 1280 100

1.1-214 1280 100  1.1-214 1280 100

1.1-3 1280 90  1.1-3 1280 90

Wie die Ergebnisse zeigen, weisen erfindungsgemäße Verbindungen, wie beispielsweise die As the results show, compounds of the invention, such as the

Verbindungen der allgemeinen Formel (I) bei Behandlung im Vorauflauf eine gute herbizide Compounds of the general formula (I) in the pre-emergence treatment a good herbicidal

Wirksamkeit gegen Schadpflanzen. Beispielsweise zeigen dabei die in den o.g. Tabellen Bl bis B13 genannten Verbindungen im Vorauflaufverfahren eine sehr gute Wirkung (80% bis 100% herbizide Wirkung) gegen Schadpflanzen wie Abutilon theophrasti (ABUTH), Alopecurus myosuroides Efficacy against harmful plants. For example, in the o.g. Tables Bl to B13 compounds in the pre-emergence a very good effect (80% to 100% herbicidal activity) against harmful plants such as Abutilon theophrasti (ABUTH), Alopecurus myosuroides

(ALOMY), Amaranthus retroflexus (AMARE), Avena fatua (AVEFA), Cyperus esculentus (CYPES), Digitaria singularis (DIGSA), Echinochloa crus-galli (ECHCG), Hordeum murinum (HORMU), Lolium rigidum (LOLRI), Polygonum convolvulus (POLCO), Setaria viridis (SETVI), Veronica persica (VERPE) und Viola tricolor (VIOTR) bei einer Aufwandmenge von 1280 g Aktivsubstanz oder weniger pro Hektar. (ALOMY), Amaranthus retroflexus (AMARE), Avena fatua (AVEFA), Cyperus esculentus (CYPES), Digitaria singularis (DIGSA), Echinochloa crus-galli (ECHCG), Hordeum murinum (HORMU), Lolium rigidum (LOLRI), Polygonum convolvulus (POLCO), Setaria viridis (SETVI), Veronica persica (VERPE) and Viola tricolor (VIOTR) at an application rate of 1280 g of active ingredient or less per hectare.

Claims

Patentansprüche : Claims: 1. Substituierte Pyrazole der allgemeinen Formel (I) oder deren Salze 1. Substituted pyrazoles of the general formula (I) or salts thereof
Figure imgf000279_0001
Figure imgf000279_0001
 worin Q für die Gruppen Q-1.1 bis Q-7.1
Figure imgf000279_0002
where Q is the groups Q-1.1 to Q-7.1
Figure imgf000279_0002
 Q-1.1 Q-1.2 Q-1.3 Q-2.1 Q-2.2
Figure imgf000279_0003
Q-1.1 Q-1.2 Q-1.3 Q-2.1 Q-2.2
Figure imgf000279_0003
 Q-2.3 -2.4 -3.1 Q-3.2 Q-4.1
Figure imgf000279_0004
Q-2.3 -2.4 -3.1 Q-3.2 Q-4.1
Figure imgf000279_0004
 Q-4.2 Q-5.1 Q-6.1 Q-7.1  Q-4.2 Q-5.1 Q-6.1 Q-7.1 steht,  stands, Z für die Gruppe
Figure imgf000279_0005
Z for the group
Figure imgf000279_0005
 steht, für Wasserstoff, Halogen, Cyano, (Ci-Cg)-Alkyl, (Ci-Cg)-Haloalkyl, (Ci-C8)-Cyanoalkyl, (Ci-C8)-Hydroxyalkyl, (Ci-C8)-Alkoxy-(Ci-C8)-alkyl, (C3-Cio)-Cycloalkyl, (C3-C10)- Cycloalkyl-(Ci-C8)-alkyl, (C3-C8)-Halocycloalkyl, (Ci-C8)-Alkoxy, (Ci-C8)-Haloalkoxy, (Ci-C8)-Alkylthio, (Ci-C8)-Haloalkylthio, (C3-C8)-Cycloalkylthio, (Ci-C8)-Alkylsulfmyl, (Ci-C8)-Haloalkylsulfmyl, (C3-C8)-Cycloalkylsulfmyl, (Ci-C8)-Alkylsulfonyl, (Ci-C8)- Haloalkylsulfonyl, (C3-C8)-cycloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-Cio)-Alkyl und (Ci-Cio)-Haloalkyl steht, für (Ci-Cio)-Alkyl und (Ci-Cio)-Haloalkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7-gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-Cio)-Alkyl, (Ci-Cio)-Haloalkyl, (C2-Cio)-Alkenyl, (C3-C10)- Alkynyl, (Ci-Cio)-Cyanoalkyl, (Ci-Cio)-Hydroxyalkyl, (C3-Cio)-Cycloalkyl, (C3-C10)- Halocycloalkyl, (C3-Cio)-Cyanocycloalkyl, (C3-Cio)-Cycloalkenyl, (Ci-Cio)-Alkyl- (C3-Cio)-cycloalkyl, (Ci-Cio)-Alkoxy-(C3-Cio)-cycloalkyl, (Ci-Cio)-Haloalkoxy-(C3-Cio)- cycloalkyl, (Ci-Cio)-Alkylthio-(C3-Cio)-cycloalkyl, Aryl-(C3-Cio)-cycloalkyl, Heteroaryl- (C3-Cio)-cycloalkyl, (Ci-Cio)-Alkoxycarbonyl-(C3-Cio)-cycloalkyl, Hydroxcarbonyl- (C3-Cio)-cycloalkyl, (C3-Cio)-Cycloalkyl-(C3-Cio)-cycloalkyl, (C3-Cio)-cycloalkyl-(Ci- Cio)-alkyl, (Ci-Cio)-Alkyloxy, (Ci-Cio)-Alkylamino, (G-Cio)-Haloalkyloxy, (C1-C10)- Haloalkylamino, (Ci-Cio)-Cycloalkyloxy, (Ci-Cio)-Cycloalkylamino, (Ci-Cio)-Alkylthio- (Ci-Cio)-alkyl, (Ci-Cio)-Alkylsulfmyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkyltsulfonyl-(Ci-Cio)- alkyl, (Ci-Cio)-Alkoxy-(Ci-Cio)- alkyl, (Ci-Cio)-Haloalkoxy-(Ci-Cio)-alkyl, Hydroxy- (Ci-Cio)-alkyl, Hydrothio-(Ci-Cio)-alkyl, Heterocyclyl-(Ci-Cio)-alkyl, Aryl-(Ci-Cio)-alkyl, Heteroaryl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkyldisulfanediyl-(Ci-Cio)-alkyl, (C1-C10)- Alkoxycarbonyl-(Ci-Cio)-alkyl, Hyroxycarbonyl-(Ci-Cio)-alkyl, Aminocarbonyl-(Ci-Cio)- alkyl, (Ci-Cio)-Alkoxycarbonyl-(C3-Cio)-cycloalkyl, Hydroxycarbonyl-(C3-Cio)-cycloalkyl, Aminocarbonyl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Alkylaminocarbonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Dialkylaminocarbonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkylaminocarbonyl-(C3-Cio)- cycloalkyl, (Ci-Cio)-Dialkylaminocarbonyl-(C3-Cio)-cycloalkyl, (Ci-Cio)-Alkylsulfonyl, (Ci-Cio)-Haloalkylsulfonyl, (C3-Cio)-Cycloalkylsulfonyl, (C3-Cio)-Halocycloalkylsulfonyl, Aminosulfonyl, (Ci-Cio)-Alkylaminosulfonyl, (Ci-Cio)-Dialkylaminosulfonyl, Heterocyclyl, (C3-Cio)-Cycloalkyl-(C3-Cio)-cycloalkyl, (C3-Cio)-Cycloalkyl-(C3-Cio)- cycloalkyl-(C3-Cio)-Cycloalkyl-(C3-Cio)-cycloalkylalkyl, Aminosulfonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Alkylaminosulfonylamino, (Ci-Cio)-Dialkylaminosulfonylamino, (Ci-Cio)- Alkoxycarbonylamino, (Ci-Cio)-Alkoxycarbonyloxy, (Ci-Cio)-Alkoxycarbonylamino- (Ci-Cio)-alkyl, (Ci-Cio)-Alkenyl, (C2-Cio)-Alkynyl steht, stands, for hydrogen, halogen, cyano, (Ci-Cg) -alkyl, (Ci-Cg) -haloalkyl, (Ci-C8) -cyanoalkyl, (Ci-C 8 ) -hydroxyalkyl, (Ci-C 8 ) -alkoxy- ( Ci-C 8) alkyl, (C 3 -Cio) cycloalkyl, (C3-C10) - cycloalkyl (Ci-C8) alkyl, (C 3 -C 8) halocycloalkyl, (Ci-C 8) alkoxy, (Ci-C8) -haloalkoxy, (Ci-C8) alkylthio, (Ci-C8) haloalkylthio, (C 3 -C 8) -cycloalkylthio, (Ci-C 8) -Alkylsulfmyl, ( Ci-C 8) -Haloalkylsulfmyl, (C 3 -C 8) -Cycloalkylsulfmyl, (Ci-C8) alkylsulfonyl, (Ci-C 8) - haloalkylsulfonyl, (C 3 -C 8) cycloalkylsulfonyl, represents oxygen, or Is sulfur, (Ci-Cio) -alkyl and (Ci-Cio) -haloalkyl, (Ci-Cio) -alkyl and (Ci-Cio) -haloalkyl, or wherein R 1 and R 2 together with the C Atom, to which they are each bonded, a fully saturated, or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, form a total 3-7 membered ring, stands for hydroxy , Amino, (Ci-C io) -alkyl, (C 1 -C 10) -haloalkyl, (C 2 -C 10) -alkenyl, (C 3 -C 10) -alkynyl, (C 1 -C 10) -cyanoalkyl, (C 1 -C 10) -hydroxyalkyl, (C 3 - Cio) cycloalkyl, (C3-C10) - halocycloalkyl, (C 3 -Cio) -Cyanocycloalkyl, (C 3 -Cio) cycloalkenyl, (Ci-Cio) alkyl- (C 3 -Cio) cycloalkyl, (C -C) alkoxy- (C 3 -Cio) -cycloalkyl, (C 1 -C 10) -haloalkoxy- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -alkylthio (C 3 -C 10) -cycloalkyl, aryl (C 3 -C 10) -cycloalkyl, heteroaryl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -alkoxycarbonyl- (C 3 -C 10) -cycloalkyl, hydroxcarbonyl- (C 3 -C 10) -cycloalkyl, ( C 3 -C 10) -cycloalkyl- (C 3 -C 10) -cycloalkyl, (C 3 -C 10) -cycloalkyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkyloxy, (C 1 -C 10) -alkylamino, (G-Cio) -haloalkyloxy, (C 1 -C 10) -haloalkylamino, (C 1 -C 10) -cycloalkyloxy, (C 1 -C 10) -cycloalkylamino, (C 1 -C 10) -alkylthio (C 1 -C 10) -alkyl, (Ci -C) -alkylsulfmyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylsulfonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxy- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkyl ) Haloalkoxy- (C 1 -C 10) -alkyl, hydroxy (C 1 -C 10) -alkyl, hydrothio (C 1 -C 10) -alkyl, heterocyclyl ( C 1 -C 10) -alkyl, aryl- (C 1 -C 10) -alkyl, heteroaryl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkyldisulfanediyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxycarbonyl - (C 1 -C 10) -alkyl, hydroxycarbonyl- (C 1 -C 10) -alkyl, aminocarbonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkoxycarbonyl- (C 3 -C 10) -cycloalkyl, hydroxycarbonyl- (C 3- Cio) -cycloalkyl, aminocarbonyl- (C 3 -Cio) -cycloalkyl, (C 1 -C 10) -alkylaminocarbonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -dialkylaminocarbonyl- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylaminocarbonyl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -dialkylaminocarbonyl- (C 3 -C 10) -cycloalkyl, (C 1 -C 10) -alkylsulfonyl, (C 1 -C 10) -haloalkylsulfonyl, (C 3 -C 10) -cycloalkylsulfonyl, (C 3 -C 10) -halocycloalkylsulfonyl, aminosulfonyl, (C 1 -C 10) -alkylaminosulfonyl, (C 1 -C 10) -dialkylaminosulfonyl, heterocyclyl, (C 3 -C 10) - Cycloalkyl- (C 3 -Cio) -cycloalkyl, (C 3 -C 10) -cycloalkyl- (C 3 -C 10) -cycloalkyl- (C 3 -C 10) -cycloalkyl- (C 3 -C 10) -cycloalkylalkyl, aminosulphonyl- (C 1 -C 10) -cycloalkyl-) ) -alkyl, (C 1 -C 10) -alkylaminosulfonylamino, (C 1 -C 10) -dialkylaminosulfonylamino, (C 1 -C 10) -alkoxycarbonylamino, (C 1 -C 10) -alkoxycarbonyloxy, (C 1 -C 10) -alkoxycarbonylamino- (C 1 -C 10) - alkyl, (C 1 -C 10) -alkenyl, (C 2 -C 10) -alkynyl, R4 für Wasserstoff, (Ci-Cio)-Alkyl, (Ci-Cio)-Haloalkyl, (C2-Cio)-Alkenyl, (C3-Cio)-Alkynyl, (Ci-Cio)-Alkoxy-(Ci-Cio)-alkyl, (Ci-Cio)-Haloalkoxy-(Ci-Cio)-alkyl, (Ci-Cio)-Alkylthio- (Ci-Cio)-alkyl, (Ci-Cio)-Haloalkylthio-(Ci-Cio)-alkyl, (C3-Cio)-Cycloalkyl, Hydroxy- (Ci-Cio)-alkylcarbonyl, Amino-(Ci-Cio)-alkyll, (Ci-Cio)-Alkoxycarbonyl-(Ci-Cio)-alkyl, (Ci-Cio)-Cyanoalkyl, (Ci-Cio)- Alkylthio-(Ci-Cio)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: R 4 represents hydrogen, (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkyl, (C 2 -C 10) -alkenyl, (C 3 -C 10) -alkynyl, (C 1 -C 10) -alkoxy- (C 1 -C 4) C 1) -alkyl, (C 1 -C 10) -haloalkoxy- (C 1 -C 10) -alkyl, (C 1 -C 10) -alkylthio (C 1 -C 10) -alkyl, (C 1 -C 10) -haloalkylthio (C 1 -C 10) -alkyl, (C 3 -Cio) -cycloalkyl, hydroxy- (Ci-Cio) -alkylcarbonyl, amino- (Ci-Cio) -alkyll, (Ci-Cio) -alkoxycarbonyl- (Ci-Cio) -alkyl, (Ci -Cio) -cyanoalkyl, (Ci-Cio) - alkylthio (Ci-Cio) -alkyl, or R 3 and R 4 with the N-atom to which they are attached, a fully saturated or partially saturated, optionally by heteroatoms form interrupted and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring, except for the compound mentioned below: 2- [3 -(2-Fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -N,N,2-trimethylpropanamid  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).  (= CAS [63687-70-7]). 2. Verbindung der allgemeinen Formel (I) gemäß Anspruch lund/oder deren Salz, dadurch 2. A compound of general formula (I) according to claim lund / or its salt, characterized gekennzeichnet, dass  marked that Q für die Gruppen Q-l . l bis Q-7.1 Q for the groups Q-l. l to Q-7.1
Figure imgf000281_0001
Figure imgf000281_0001
Figure imgf000282_0001
Figure imgf000282_0001
 steht, für die Gruppe
Figure imgf000282_0002
steht, für Wasserstoff, Halogen, Cyano, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (Ci-C6)-Cyanoalkyl, (Ci-C6)-Hydroxyalkyl, (Ci-C6)-Alkoxy-(Ci-C6)-alkyl, (C3-C8)-Cycloalkyl, (C3-C8)- Cycloalkyl-(Ci-C6)-alkyl, (C3-C8)-Halocycloalkyl, (Ci-C6)-Alkoxy, (Ci-C6)-Haloalkoxy, (Ci-C6)-Alkylthio, (Ci-C6)-Haloalkylthio, (C3-C6)-Cycloalkylthio, (Ci-C6)-Alkylsulfmyl, (Ci-C6)-Haloalkylsulfmyl, (C3-C6)-Cycloalkylsulfmyl, (Ci-C6)-Alkylsulfonyl, (Ci-C6)- Haloalkylsulfonyl, (C3-C6)-cycloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-C6)-Alkyl und (Ci-C8)-Haloalkyl steht, für (Ci-C8)-Alkyl und (Ci-C8)-Haloalkyl, steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7-gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-C8)-Alkyl, (Ci-C8)-Haloalkyl, (C2-C8)-Alkenyl, (C3-C8)-Alkynyl, (Ci-C8)-Cyanoalkyl, (Ci-C8)-Hydroxyalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Cyanocycloalkyl, (C3-C8)-Cycloalkenyl, (Ci-C8)-Alkyl-(C3-C8)-cycloalkyl, (Ci-C8)-Alkoxy-(C3-C8)-cycloalkyl, (Ci-C8)-Haloalkoxy-(C3-C8)-cycloalkyl, (Ci-C8)- Alkylthio-(C3-C8)-cycloalkyl, Aryl-(C3-C8)-cycloalkyl, Heteroaryl-(C3-C8)-cycloalkyl, (Ci-C8)-Alkoxycarbonyl-(C3-C8)-cycloalkyl, Hydroxcarbonyl-(C3-C8)-cycloalkyl, (C3-C8)- Cycloalkyl-(C3-C8)-cycloalkyl, (C3-C8)-cycloalkyl-(Ci-C8)-alkyl, (Ci-C8)-Alkyloxy, (Ci- C8)-Alkylamino, (Ci-C8)-Haloalkyloxy, (Ci-C8)-Haloalkylamino, (Ci-C8)-Cycloalkyloxy, (Ci-C8)-Cycloalkylamino, (Ci-C8)-Alkylthio-(Ci-C8)-alkyl, (Ci-C8)-Alkylsulfmyl-(Ci-C8)- alkyl, (Ci-C8)-Alkylsulfonyl-(Ci-C8)-alkyl, (Ci-C8)-Alkoxy-(Ci-C8)-alkyl, (Ci-C8)- Haloalkoxy-(Ci-C8)-alkyl, Hydroxy-(Ci-C8)-alkyl, Hydrothio-(Ci-C8)-alkyl, Heterocyclyl- (Ci-C8)-alkyl, Aryl-(Ci-C8)-alkyl, Heteroaryl-(Ci-C8)-alkyl, (Ci-C8)-Alkyldisulfanediyl- (Ci-C8)-alkyl, (Ci-C8)-Alkoxycarbonyl-(Ci-C8)-alkyl, Hyroxycarbonyl-(Ci-C8)-alkyl, Aminocarbonyl-(Ci-C8)-alkyl, (Ci-C8)-Alkoxycarbonyl-(C3-C8)-cycloalkyl, stands for the group
Figure imgf000282_0002
is hydrogen, halogen, cyano, (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, (C 1 -C 6 ) -cyanoalkyl, (C 1 -C 6 ) -hydroxyalkyl, (C 1 -C 6 ) -alkoxy (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl- (C 1 -C 6 ) -alkyl, (C 3 -C 8 ) -halocycloalkyl, ( Ci-C 6) alkoxy, (Ci-C 6) -haloalkoxy, (Ci-C 6) alkylthio, (Ci-C 6) haloalkylthio, (C 3 -C 6) -cycloalkylthio, (Ci-C 6 ) -Alkylsulfmyl, (Ci-C 6) -Haloalkylsulfmyl, (C 3 -C 6) -Cycloalkylsulfmyl, (Ci-C 6) alkylsulfonyl, (Ci-C 6) - haloalkylsulfonyl, (C 3 -C 6) cycloalkylsulfonyl is , is oxygen or sulfur, (C 1 -C 6 ) -alkyl and (C 1 -C 8 ) -haloalkyl, represents (C 1 -C 8 ) -alkyl and (C 1 -C 8 ) -haloalkyl, or wherein R 1 and R 2 together with the C-atom to which they are each bonded, a fully saturated, or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, a total of 3-7 to form a -linked ring, hydroxy, amino, (Ci-C 8) -alkyl, (Ci-C8) -haloalkyl, (C 2 -C 8) -alkenyl, (C 3 -C 8) alkynyl, (Ci-C 8) - Cyanoalkyl, (C 1 -C 8 ) -hydroxyalkyl, (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -halocycloalkyl, (C 3 -C 8 ) -cyanocycloalkyl, (C 3 -C 8 ) -cycloalkenyl , (Ci-C 8) alkyl (C 3 -C 8) cycloalkyl, (Ci-C 8) alkoxy (C 3 -C 8) cycloalkyl, (Ci-C8) haloalkoxy (C 3 -C 8) cycloalkyl, (Ci-C 8) - alkylthio (C 3 -C 8) cycloalkyl, aryl (C 3 -C 8) cycloalkyl, heteroaryl (C 3 -C 8) cycloalkyl , (C 1 -C 8 ) -alkoxycarbonyl- (C 3 -C 8 ) -cycloalkyl, hydroxcarbonyl- (C 3 -C 8 ) -cycloalkyl, (C 3 -C 8 ) -cycloalkyl- (C 3 -C 8 ) - cycloalkyl, (C 3 -C 8) cycloalkyl- (Ci-C 8) alkyl, (Ci-C8) alkyloxy, (Ci C 8) alkylamino, (Ci-C 8) -Haloalkyloxy, (C -C 8) -Haloalkylamino, (Ci-C8) cycloalkyloxy, (Ci-C8) cycloalkylamino, (Ci-C8) alkylthio (Ci-C8) alkyl, (Ci-C 8) - Alkylsulfmyl- (Ci-C 8) - alkyl, (Ci-C8) alkylsulfonyl (Ci-C 8) alkyl, (Ci-C 8) alkoxy (Ci-C 8) alkyl, (Ci- C 8 ) - haloalkoxy- (C 1 -C 8 ) -alkyl , Hydroxy (Ci-C 8) alkyl, Hydrothio- (Ci-C 8) alkyl, heterocyclyl (Ci-C 8) alkyl, aryl (Ci-C 8) alkyl, heteroaryl (Ci- C 8 ) -alkyl, (C 1 -C 8 ) -alkyldisulfanediyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkoxycarbonyl- (C 1 -C 8 ) -alkyl, hyroxycarbonyl- (C 1 -C 8 ) alkyl, aminocarbonyl (Ci-C8) alkyl, (Ci-C8) alkoxycarbonyl (C 3 -C 8) cycloalkyl, Hydroxycarbonyl-(C3-C8)-cycloalkyl, Aminocarbonyl-(C3-C8)-cycloalkyl, (Ci-Cs)- Alkylaminocarbonyl-(Ci-C8)-alkyl, (Ci-C8)-Dialkylaminocarbonyl-(Ci-C8)-alkyl, (Ci-Cs)- Alkylaminocarbonyl-(C3-C8)-cycloalkyl, (Ci-C8)-Dialkylaminocarbonyl-(C3-C8)- cycloalkyl, (Ci-C8)-Alkylsulfonyl, (Ci-C8)-Haloalkylsulfonyl, (C3-C8)-Cycloalkylsulfonyl, (C3-C8)-Halocycloalkylsulfonyl, Aminosulfonyl, (Ci-C8)-Alkylaminosulfonyl, (Ci-Cs)- Dialkylaminosulfonyl, Heterocyclyl, (C3-C8)-Cycloalkyl-(C3-C8)-cycloalkyl, (C3-C8)- Cycloalkyl-(C3-C8)-cycloalkyl-(C3-C8)-Cycloalkyl-(C3-C8)-cycloalkylalkyl, Hydroxycarbonyl (C 3 -C 8) cycloalkyl, aminocarbonyl (C 3 -C 8) cycloalkyl, (Ci-Cs) - alkylaminocarbonyl (Ci-C8) alkyl, (Ci-C 8) dialkylaminocarbonyl (Ci-C 8) alkyl, (Ci-Cs) - alkylaminocarbonyl (C 3 -C 8) cycloalkyl, (Ci-C 8) dialkylaminocarbonyl (C 3 -C 8) - cycloalkyl, (Ci-C 8) alkylsulfonyl, (Ci-C 8) haloalkylsulfonyl, (C 3 -C 8) cycloalkylsulfonyl, (C 3 -C 8) -Halocycloalkylsulfonyl, aminosulfonyl, (Ci-C 8) alkylaminosulfonyl, (Ci-Cs) - dialkylaminosulfonyl, heterocyclyl, (C 3 -C 8) cycloalkyl (C 3 -C 8) cycloalkyl, (C 3 -C 8) - cycloalkyl (C 3 -C 8) cycloalkyl (C 3 -C 8 ) -cycloalkyl- (C 3 -C 8 ) -cycloalkylalkyl, Aminosulfonyl-(Ci-C8)-alkyl, (Ci-C8)-Alkylaminosulfonylamino, (Ci-Cs)- Dialkylaminosulfonylamino, (Ci-C8)-AlkoxyCarbonylamino, (Ci-C8)-Alkoxycarbonyloxy, (Ci-C8)-Alkoxycarbonylamino-(Ci-C8)-alkyl, (Ci-Cg)-Alkenyl, (C2-C8)-Alkynyl steht, für Wasserstoff, (Ci-C8)-Alkyl, (Ci-C8)-Haloalkyl, (C2-C8)-Alkenyl, (C3-C8)-Alkynyl, (Ci-C8)-Alkoxy-(Ci-C8)-alkyl, (Ci-C8)-Haloalkoxy-(Ci-C8)-alkyl, (Ci-C8)-Alkylthio- (Ci-C8)-alkyl, (Ci-C8)-Haloalkylthio-(Ci-C8)-alkyl, (C3-C8)-Cycloalkyl, Hydroxy-(Ci-C8)- alkylcarbonyl, Amino-(Ci-C8)-alkyl, (Ci-C8)-Alkoxycarbonyl-(Ci-C8)-alkyl, (Ci-Cs)- Cyanoalkyl, (Ci-Cg)- Alkylthio-(Ci-C8)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, Aminosulfonyl- (Ci-C 8 ) alkyl, (Ci-C 8 ) -Alkylaminosulfonylamino, (Ci-Cs) - Dialkylaminosulfonylamino, (Ci-C 8 ) -AlkoxyCarbonylamino, (Ci-C 8 ) -Alkoxycarbonyloxy, (Ci-C 8 ) -alkoxycarbonylamino- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkenyl, (C 2 -C 8 ) -alkynyl, for hydrogen, (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) haloalkyl, (C 2 -C 8) -alkenyl, (C 3 -C 8) alkynyl, (Ci-C 8) alkoxy (Ci-C 8) alkyl, (Ci-C8) haloalkoxy (Ci-C 8) alkyl, (Ci-C8) alkylthio (Ci-C8) alkyl, (Ci-C 8) -Haloalkylthio- (Ci-C 8) alkyl, (C 3 -C 8 ) -cycloalkyl, hydroxy- (C 1 -C 8 ) -alkylcarbonyl, amino- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkoxycarbonyl- (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) - Cyanoalkyl, (Ci-Cg) - alkylthio (Ci-C 8 ) alkyl, or R 3 and R 4 with the N-atom to which they are attached, a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring form, is, ausgenommen der nachfolgend genannten Verbindung: 2- [3 -(2-Fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -N,N,2-trimethylpropanamid except for the following compound: 2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).  (= CAS [63687-70-7]). 3. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1 und/oder deren Salz, dadurch gekennzeichnet, dass 3. Compounds of the general formula (I) according to claim 1 and / or their salt, characterized in that Q für die Gruppen Q-l . l bis Q-7.1 Q for the groups Q-l. l to Q-7.1
Figure imgf000284_0001
Figure imgf000284_0001
 steht,  stands, Z für die Gruppe
Figure imgf000284_0002
steht, Z for the group
Figure imgf000284_0002
stands, Y für Wasserstoff, Fluor, Chlor, Brom, lod, Cyano, (Ci-C4)-Alkyl, (Ci-C4)-Haloalkyl, Y is hydrogen, fluorine, chlorine, bromine, iodine, cyano, (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)- Alkylthio, (Ci-C4)-Haloalkylthio, (Ci-C4)-Alkylsulfmyl, (Ci-C4)-Haloalkylsulfmyl, (Ci-C4)-Alkylsulfonyl, (Ci-C4)-Haloalkylsulfonyl steht, für Sauerstoff oder Schwefel steht, für (Ci-C6)-Alkyl und (Ci-C6)-Haloalkyl steht, für (Ci-C6)-Alkyl und (Ci-C6)-Haloalkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-7-gliedrigen Ring bilden, steht, für Hydroxy, Amino, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C2-C6)-Alkenyl, (C3-C6)-Alkynyl, (Ci-C6)-Cyanoalkyl, (Ci-C6)-Hydroxyalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Cyanocycloalkyl, (C3-C6)-Cycloalkenyl, (Ci-C6)-Alkyl-(C3-C6)-cycloalkyl, (Ci-C6)-Alkoxy-(C3-C6)-cycloalkyl, (Ci-C6)-Haloalkoxy-(C3-C6)-cycloalkyl, (Ci-C6)- Alkylthio-(C3-C6)-cycloalkyl, Aryl-(C3-C6)-cycloalkyl, Heteroaryl-(C3-C6)-cycloalkyl, (Ci-C6)-Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxcarbonyl-(C3-C6)-cycloalkyl, (C3-C6)- Cycloalkyl-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(Ci-C6)-alkyl, (Ci-C6)-Alkyloxy, (Ci- C6)-Alkylamino, (Ci-C6)-Haloalkyloxy, (Ci-C6)-Haloalkylamino, (Ci-C6)-Cycloalkyloxy, (Ci-C6)-Cycloalkylammo, (Ci-C6)-Alkylthio-(Ci-C6)-alkyl, (Ci-C6)-Alkylsulfmyl-(Ci-C6)- alkyl, (Ci-C6)-Alkylsulfonyl-(Ci-C6)-alkyl, (Ci-C6)-Alkoxy-(Ci-C6)-alkyl, (Ci-C6)- Haloalkoxy-(Ci-C6)-alkyl, Hydroxy-(Ci-C6)-alkyl, Hydrothio-(Ci-C6)-alkyl, Heterocyclyl- (Ci-C6)-alkyl, Aryl-(Ci-C6)-alkyl, Heteroaryl-(Ci-C6)-alkyl, (Ci-C6)-Alkyldisulfanediyl- (Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl-(Ci-C6)-alkyl, Hydroxycarbonyl-(Ci-C6)-alkyl, Aminocarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl-(C3-C6)-cycloalkyl, (C 3 -C 6) -cycloalkyl, (C 3 -C 6) halocycloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (Ci-C4) - alkylthio, (Ci- C 4 ) -haloalkylthio, (C 1 -C 4 ) -alkylsulfmyl, (C 1 -C 4 ) -haloalkylsulfmyl, (C 1 -C 4 ) -alkylsulfonyl, (C 1 -C 4 ) -haloalkylsulfonyl, is oxygen or sulfur, (C 1 -C 6 ) -alkyl and (C 1 -C 6 ) -haloalkyl, (C 1 -C 6 ) -alkyl and (C 1 -C 6 ) -haloalkyl, or where R 1 and R 2 together with the C-atom to which they are each bonded, a fully saturated, or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, total 3-7-membered Ring, stands for hydroxy, amino, (Ci-C 6 ) alkyl, (Ci-C 6 ) -haloalkyl, (C 2 -C 6 ) -alkenyl, (C 3 -C 6 ) -alkynyl, (Ci -C 6 ) -cyanoalkyl, (C 1 -C 6 ) -hydroxyalkyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -halocycloalkyl, (C 3 -C 6 ) -cyanocycloalkyl, (C 3 - C 6) cycloalkenyl, (Ci-C 6) -alkyl- (C 3 -C 6) cycloalkyl, (Ci-C 6) alkoxy (C 3 -C 6) cycloalkyl, (Ci-C 6) haloalkoxy (C 3 -C 6) cycloalkyl, (Ci-C 6) - alkylthio, (C 3 -C 6) cycloalkyl, aryl (C 3 -C 6) cycloalkyl, heteroaryl (C 3 -C 6) cycloalkyl, (C 1 -C 6) alkoxycarbonyl- (C 3 -C 6) cycloalkyl, hydroxycarbonyl- (C 3 C6) cycloalkyl, (C3-C6) - cycloalkyl (C 3 -C 6) cycloalkyl, (C 3 -C 6) -cycloalkyl- (Ci-C 6) alkyl, (Ci-C 6) - Alkyloxy, (C 1 -C 6 ) -alkylamino, (C 1 -C 6 ) -haloalkyloxy, (C 1 -C 6 ) -haloalkylamino, (C 1 -C 6 ) -cycloalkyloxy, (C 1 -C 6 ) -cycloalkylammo, (C 1 -C 6 ) - alkylthio (Ci-C 6) alkyl, (Ci-C6) -Alkylsulfmyl- (Ci-C 6) - alkyl, (Ci-C 6) alkylsulfonyl (Ci-C 6) alkyl, (Ci-C 6 ) -alkoxy- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkoxy- (C 1 -C 6 ) -alkyl, hydroxy- (C 1 -C 6 ) -alkyl, hydrothio- (C 1 -C 6 ) -alkyl , Heterocyclyl- (C 1 -C 6 ) -alkyl, aryl- (C 1 -C 6 ) -alkyl, heteroaryl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkyldisulfanediyl- (C 1 -C 6 ) -alkyl , (C 1 -C 6) -alkoxycarbonyl- (C 1 -C 6) -alkyl, hydroxycarbonyl- (C 1 -C 6) -alkyl, aminocarbonyl- (C 1 -C 6) -alkyl, (C 1 -C 6) -alkoxycarbonyl- (C 3 -C 6) ) cycloalkyl, Hydroxycarbonyl-(C3-C6)-cycloalkyl, Aminocarbonyl-(C3-C6)-cycloalkyl, (Ci-Ce)- Alkylaminocarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Dialkylaminocarbonyl-(Ci-C6)-alkyl, (Ci-Ce)- Alkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C6)-Dialkylaminocarbonyl-(C3-C6)- cycloalkyl, (Ci-C6)-Alkylsulfonyl, (Ci-C6)-Haloalkylsulfonyl, (C3-C6)-Cycloalkylsulfonyl, Aminosulfonyl, (Ci-C6)-Alkylaminosulfonyl, (Ci-C6)-Dialkylaminosulfonyl, Heterocyclyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl-(C3-C6)- Cycloalkyl-(C3-C6)-cycloalkylalkyl, Aminosulfonyl-(Ci-C6)-alkyl, (Ci-Ce)- Alkylaminosulfonylamino, (Ci-C6)-Dialkylaminosulfonylamino, (Ci-Ce)- AlkoxyCarbonylamino, (Ci-C6)-Alkoxycarbonyloxy, (Ci-C6)-Alkoxycarbonylamino- (Ci-C6)-alkyl, (Ci-C6)-Alkenyl, (C2-C6)-Alkynyl, steht, R für Wasserstoff, (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C2-C6)-Alkenyl, (C3-C6)-Alkynyl, (Ci-C6)-Alkoxy-(Ci-C6)-alkyl, (Ci-C6)-Haloalkoxy-(Ci-C6)-alkyl, (Ci-C6)-Alkylthio- (Ci-C6)-alkyl, (Ci-C6)-Haloalkylthio-(Ci-C6)-alkyl, (C3-C6)-Cycloalkyl, Hydroxy-(Ci-C6)- alkylcarbonyl, Amino-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl-(Ci-C6)-alkyl, (Ci-Ce)- Cyanoalkyl, (Ci-C6)- Alkylthio-(Ci-C6)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: Hydroxycarbonyl- (C 3 -C 6) -cycloalkyl, aminocarbonyl- (C 3 -C 6) -cycloalkyl, (C 1 -C 6) -alkylaminocarbonyl- (C 1 -C 6) -alkyl, (C 1 -C 6) -dialkylaminocarbonyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6) -alkylaminocarbonyl- (C 3 -C 6) -cycloalkyl, (C 1 -C 6) -dialkylaminocarbonyl- (C 3 -C 6) -cycloalkyl, (C 1 -C 6) -alkylsulfonyl, (C 1 -C 6) ) -Haloalkylsulfonyl, (C 3 -C 6) -cycloalkylsulfonyl, aminosulfonyl, (C 1 -C 6 ) -alkylaminosulfonyl, (C 1 -C 6 ) -dialkylaminosulfonyl, heterocyclyl, (C 3 -C 6 ) -cycloalkyl- (C 3 -C 6 ) cycloalkyl, (C 3 -C 6) cycloalkyl (C 3 -C 6) cycloalkyl (C 3 -C 6) - cycloalkyl (C3-C6) cycloalkylalkyl, aminosulphonyl (Ci-C6) alkyl , (C 1 -C 6 ) -alkylaminosulfonylamino, (C 1 -C 6 ) -dialkylaminosulfonylamino, (C 1 -C 6 ) -alkoxycarbonylamino, (C 1 -C 6 ) -alkoxycarbonyloxy, (C 1 -C 6 ) -alkoxycarbonylamino- (C 1 -C 6 ) -alkyl, (Ci-C 6) alkenyl, (C 2 -C 6) alkynyl, stands, R is hydrogen, (Ci-C 6) -alkyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) -alkenyl, (C 3 -C 6) alkynyl, (Ci-C 6) alkoxy - (Ci-C 6 ) -alkyl, (Ci-C 6 ) -haloalkoxy- (Ci-C 6 ) -alkyl, (Ci-C 6 ) -alkylthio (Ci-C 6 ) -alkyl, (Ci-C6 ) -Haloalkylthio- (Ci-C 6) alkyl, (C 3 -C 6) cycloalkyl, hydroxy (Ci-C 6) - alkylcarbonyl, amino (Ci-C6) alkyl, (Ci-C6) - Alkoxycarbonyl (Ci-C6) -alkyl, (Ci-Ce) - Cyanoalkyl, (Ci-C 6 ) - alkylthio (Ci-C 6 ) -alkyl, or R 3 and R 4 with the N-atom, to which are bonded to form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is, except the following compound: 2- [3 -(2-Fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -N,N,2-trimethylpropanamid  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).  (= CAS [63687-70-7]). 4. Verbindungen der allgemeinen Formel (I) gemäß Anspruch lund/oder deren Salz, dadurch 4. Compounds of general formula (I) according to claim lund / or salt thereof, characterized gekennzeichnet, dass  marked that Q für die Gruppen Q-l . l bis Q-7.1 Q for the groups Q-l. l to Q-7.1
Figure imgf000286_0001
Figure imgf000286_0001
 Q-l . l Q-1.2 Q-1.3 Q-2.1 Q-2.2 Q-l. l Q-1.2 Q-1.3 Q-2.1 Q-2.2
Figure imgf000286_0002
Figure imgf000286_0002
 Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1  Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1
Figure imgf000286_0003
Figure imgf000286_0003
 Q-4.2 Q-5.1 Q-6.1 Q-7.1 steht, Z für die Gruppe
Figure imgf000287_0001
steht, Q-4.2 Q-5.1 Q-6.1 Q-7.1 stands, Z for the group
Figure imgf000287_0001
stands, Y für Wasserstoff, Fluor, Chlor, Brom, Iod, Cyano, (Ci-C2)-Alkyl, (Ci-C2)-Haloalkyl, Y is hydrogen, fluorine, chlorine, bromine, iodine, cyano, (C 1 -C 2 ) -alkyl, (C 1 -C 2 ) -haloalkyl, (C3-C4)-Cycloalkyl, (Ci-C2)-Alkoxy, (Ci-C2)-Haloalkoxy, (Ci-C2)-Alkylthio, (C1-C2)- Haloalkylthio, (Ci-C2)-Alkylsulfmyl, (Ci-C2)-Haloalkylsulfmyl, (Ci-C2)-Alkylsulfonyl, (Ci-C2)-Haloalkylsulfonyl steht, (C 3 -C 4) cycloalkyl, (Ci-C 2) alkoxy, (Ci-C2) haloalkoxy, (Ci-C2) alkylthio, (C1-C2) - haloalkylthio, (Ci-C 2 ) -Alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 2 ) -alkylsulfonyl, (C 1 -C 2 ) -haloalkylsulfonyl, W für Sauerstoff oder Schwefel steht, W is oxygen or sulfur, R1 für (Ci-C2)-Alkyl steht, R2 für (Ci-C2)-Alkyl steht, oder wobei R1 und R2 zusammen mit dem C-Atom, an das sie jeweils gebunden sind, einen vollständig gesättigten, oder teilgesättigten, gegebenenfalls durch ein bis drei Heteroatome aus der Gruppe N, O und S unterbrochenen und gegebenenfalls weiter substituierten, insgesamt 3-4-gliedrigen Ring bilden, steht, R 1 is (C 1 -C 2 ) -alkyl, R 2 is (C 1 -C 2 ) -alkyl, or where R 1 and R 2 together with the carbon atom to which they are each bonded form a completely saturated , or partially saturated, optionally interrupted by one to three heteroatoms from the group N, O and S and optionally further substituted, form a total 3-4-membered ring is, R3 für Hydroxy, Amino, (Ci-C4)-Alkyl, (Ci-C4)-Haloalkyl, (C2-C4)-Alkenyl, (C3-C4)-Alkynyl, (Ci-C4)-Cyanoalkyl, (Ci-C4)-Hydroxyalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Cyanocycloalkyl, (C3-C6)-Cycloalkenyl, (Ci-C4)-Alkyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkoxy-(C3-C6)-cycloalkyl, (Ci-C4)-Haloalkoxy-(C3-C6)-cycloalkyl, (C1-C4)-R 3 is hydroxy, amino, (Ci-C 4) alkyl, (Ci-C 4) -haloalkyl, (C 2 -C 4) alkenyl, (C 3 -C 4) alkynyl, (Ci-C 4 ) -Cyanoalkyl, (C 1 -C 4 ) -hydroxyalkyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -halocycloalkyl, (C 3 -C 6 ) -cyanocycloalkyl, (C 3 -C 6 ) Cycloalkenyl, (C 1 -C 4 ) -alkyl- (C 3 -C 6 ) -cycloalkyl, (C 1 -C 4 ) -alkoxy- (C 3 -C 6 ) -cycloalkyl, (C 1 -C 4 ) -haloalkoxy- (C 3 -C 6 ) -cycloalkyl, (C 1 -C 4 ) - Alkylthio-(C3-C6)-cycloalkyl, Aryl-(C3-C6)-cycloalkyl, Heteroaryl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxcarbonyl-(C3-C6)-cycloalkyl, (C3-C6)- Cycloalkyl-(C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(Ci-C4)-alkyl, (Ci-C4)-Alkyloxy, (Ci- C4)-Alkylamino, (Ci-C4)-Haloalkyloxy, (Ci-C4)-Haloalkylamino, (Ci-C4)-Alkylthio- (Ci-C4)-alkyl, (Ci-C4)-Alkylsulfmyl-(Ci-C4)-alkyl, (Ci-C4)-Alkylsulfonyl-(Ci-C4)-alkyl,Alkylthio (C 3 -C 6) cycloalkyl, aryl (C 3 -C 6) cycloalkyl, heteroaryl (C 3 -C 6) cycloalkyl, (C 1 -C 4 ) -alkoxycarbonyl (C 3 -C 6) cycloalkyl , Hydroxcarbonyl- (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl- (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl- (C 1 -C 4 ) -alkyl, ( Ci-C 4) -alkyloxy, (Ci C 4) alkylamino, (Ci-C 4) -Haloalkyloxy, (Ci-C 4) -Haloalkylamino, (Ci-C 4) alkylthio (Ci-C 4) alkyl, (C 1 -C 4 ) -alkylsulfmyl (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkylsulfonyl- (C 1 -C 4 ) -alkyl, (Ci-C4)-Alkoxy-(Ci-C4)-alkyl, (Ci-C4)-Haloalkoxy-(Ci-C4)-alkyl, Hydroxy-(Ci-C4)-alkyl, Hydrothio-(Ci-C4)-alkyl, Heterocyclyl-(Ci-C4)-alkyl, Aryl-(Ci-C4)-alkyl, Heteroaryl- (Ci-C4)-alkyl, (Ci-C4)-Alkyldisulfanediyl-(Ci-C4)-alkyl, (Ci-C4)-Alkoxycarbonyl-(Ci-C4)- alkyl, Hydroxycarbonyl-(Ci-C4)-alkyl, Aminocarbonyl-(Ci-C4)-alkyl, (C1-C4)- Alkoxycarbonyl-(C3-C6)-cycloalkyl, Hydroxycarbonyl-(C3-C6)-cycloalkyl, Aminocarbonyl- (C3-C6)-cycloalkyl, (Ci-C4)-Alkylaminocarbonyl-(Ci-C4)-alkyl, (C1-C4)- Dialkylaminocarbonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Dialkylaminocarbonyl-(C3-C6)-cycloalkyl, (Ci-C4)-Alkylsulfonyl, (C1-C4)- Haloalkylsulfonyl, (C3-C6)-Cycloalkylsulfonyl, Aminosulfonyl, (C1-C4)- Alkylaminosulfonyl, (Ci-C4)-Dialkylaminosulfonyl, Heterocyclyl, (C3-C6)-Cycloalkyl-(C3- C6)-cycloalkyl, (C3-C6)-Cycloalkyl-(C3-C6)-cycloalkyl-(C3-C6)-Cycloalkyl-(C3-C6)- cycloalkylalkyl, Aminosulfonyl-(Ci-C4)-alkyl, (Ci-C4)-Alkylaminosulfonylamino, (C1-C4)- Dialkylaminosulfonylamino, (Ci-C4)-Alkoxycarbonylamino, (Ci-C4)-Alkoxycarbonyloxy, (Ci-C4)-Alkoxycarbonylamino-(Ci-C4)-alkyl, (Ci-C4)-Alkenyl, (C2-C4)-Alkynyl steht, (C 1 -C 4 ) -alkoxy- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -haloalkoxy- (C 1 -C 4 ) -alkyl, hydroxy- (C 1 -C 4 ) -alkyl, hydrothio ( C 1 -C 4 ) -alkyl, heterocyclyl- (C 1 -C 4 ) -alkyl, aryl- (C 1 -C 4 ) -alkyl, heteroaryl- (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -alkyldisulfanediyl- (Ci-C 4) alkyl, (Ci-C4) alkoxycarbonyl (Ci-C4) - alkyl, hydroxycarbonyl- (Ci-C 4) alkyl, aminocarbonyl (Ci-C 4) alkyl, ( C 1 -C 4) -alkoxycarbonyl- (C 3 -C 6) -cycloalkyl, hydroxycarbonyl- (C 3 -C 6) -cycloalkyl, aminocarbonyl- (C3-C6) cycloalkyl, (Ci-C4) alkylaminocarbonyl (Ci-C 4) alkyl, (C 1 -C 4) - dialkylaminocarbonyl (Ci-C4) alkyl, (Ci-C4) - Alkylaminocarbonyl- (C 3 -C 6 ) -cycloalkyl, (C 1 -C 4 ) -dialkylaminocarbonyl- (C 3 -C 6 ) -cycloalkyl, (C 1 -C 4 ) -alkylsulfonyl, (C 1 -C 4 ) -haloalkylsulfonyl, (C 3 -C 6 ) - Cycloalkylsulfonyl, aminosulfonyl, (C 1 -C 4 ) -alkylaminosulfonyl, (C 1 -C 4 ) -dialkylaminosulfonyl, heterocyclyl, (C 3 -C 6 ) -cycloalkyl- (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl- (C 1 -C 4 ) -alkyl) C 3 -C 6 ) -cycloalkyl- (C 3 -C 6 ) -cycloalkyl- (C 3 -C 6 ) -cycloalkylalkyl, aminosulphonyl- (C 1 -C 4) -alkyl, (C 1 -C 4) -alkylaminosulphonylamino, (C 1 -C 4) -dialkylaminosulphonylamino, (C 1 -C 4) -alkoxycarbonylamino, C 1 -C 4 -alkoxycarbonyloxy, C 1 -C 4 -alkoxycarbonylamino- (C 1 -C 4) -alkyl, C 1 -C 4 -alkenyl, C 2 -C 4 -alkynyl, R4 für Wasserstoff, (Ci-C6)-Alkyl, Hydroxycarbonyl-(Ci-C6)-alkyl, (Ci-C6)-Alkoxycarbonyl- (Ci-C6)-alkyl steht, oder R3 und R4 mit dem N-Atom, an das sie gebunden sind, einen vollständig gesättigten oder teilgesättigten, gegebenenfalls durch Heteroatome unterbrochenen und gegebenenfalls weiter substituierten 3 bis 10-gliedrigen monocyclischen oder bicyclischen Ring bilden, steht, ausgenommen der nachfolgend genannten Verbindung: R 4 is hydrogen, (C 1 -C 6 ) -alkyl, hydroxycarbonyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxycarbonyl- (C 1 -C 6 ) -alkyl, or R 3 and R 4 with the N Atom to which they are attached form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 3 to 10-membered monocyclic or bicyclic ring is, except for the compound mentioned below: 2- [3 -(2-Fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -N,N,2-trimethylpropanamid  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7])  (= CAS [63687-70-7]) 5. Verbindungen der allgemeinen Formel (I) gemäß Anspruch 1 und/oder deren Salz, dadurch 5. Compounds of general formula (I) according to claim 1 and / or salt thereof, characterized gekennzeichnet, dass  marked that Q für die Gruppen Q-l .1 bis Q-7.1 Q for the groups Q-1 .1 to Q-7.1
Figure imgf000288_0001
Figure imgf000288_0001
 Q-l . l Q-1.2 Q-1.3 Q-2.1 Q-2.2 Q-l. l Q-1.2 Q-1.3 Q-2.1 Q-2.2
Figure imgf000288_0002
Figure imgf000288_0002
 Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1
Figure imgf000289_0001
Q-2.3 Q-2.4 Q-3.1 Q-3.2 Q-4.1
Figure imgf000289_0001
 steht,  stands, Z für die Gruppen Z- 1.1 bis Z-5.1  Z for the groups Z-1.1 to Z-5.1
Figure imgf000289_0002
Figure imgf000290_0001
Figure imgf000291_0001
Figure imgf000289_0002
Figure imgf000290_0001
Figure imgf000291_0001
Figure imgf000292_0001
Figure imgf000292_0001
Figure imgf000293_0001
Figure imgf000293_0001
Figure imgf000294_0001
Figure imgf000294_0001
Figure imgf000295_0001
Figure imgf000296_0001
Figure imgf000295_0001
Figure imgf000296_0001
Figure imgf000297_0001
Figure imgf000297_0001
Figure imgf000298_0001
Figure imgf000298_0001
Figure imgf000299_0001
Figure imgf000300_0001
Figure imgf000301_0001
steht,
Figure imgf000299_0001
Figure imgf000300_0001
Figure imgf000301_0001
stands, Y für Wasserstoff, Fluor, Chlor, Brom, Iod, Cyano, (Ci-C2)-Alkyl, (Ci-C2)-Haloalkyl, (C3-C4)-Cycloalkyl, (Ci-C2)-Alkoxy, (Ci-C2)-Haloalkoxy, (Ci-C2)-Alkylthio, (C1-C2)-Y represents hydrogen, fluorine, chlorine, bromine, iodine, cyano, (Ci-C 2) alkyl, (Ci-C 2) -haloalkyl, (C 3 -C 4) cycloalkyl, (Ci-C 2) alkoxy , (C 1 -C 2 ) -haloalkoxy, (C 1 -C 2 ) -alkylthio, (C 1 -C 2 ) - Haloalkylthio, (Ci-C2)-Alkylsulfmyl, (Ci-C2)-Haloalkylsulfmyl, (Ci-C2)-Alkylsulfonyl, (Ci-C2)-Haloalkylsulfonyl steht, Haloalkylthio, (C 1 -C 2 ) -alkylsulfmyl, (C 1 -C 2 ) -haloalkylsulfmyl, (C 1 -C 2 ) -alkylsulfonyl, (C 1 -C 2 ) -haloalkylsulfonyl, W für Sauerstoff oder Schwefel steht: W is oxygen or sulfur: R1 für CH3 steht, für CH3 steht, ausgenommen der nachfolgend genannten Verbindung: R 1 is CH 3, is CH 3 , except for the compound mentioned below: 2- [3 -(2-Fluorphenyl)-4-methyl- 1 H-pyrazol- 1 -yl] -N,N,2-trimethylpropanamid  2- [3- (2-fluorophenyl) -4-methyl-1H-pyrazol-1-yl] -N, N, 2-trimethylpropanamide (= CAS [63687-70-7]).  (= CAS [63687-70-7]). 6. Verwendung einer oder mehrere Verbindungen der allgemeinen Formel (I) und/oder deren Salzen wie in einem der Ansprüche 1 bis 5 definiert, als Herbizid und/oder 6. Use of one or more compounds of the general formula (I) and / or salts thereof as defined in any one of claims 1 to 5, as a herbicide and / or Pflanzenwachstumsregulator. Herbizides und/oder pflanzenwachstumsregulierendes Mittel, dadurch gekennzeichnet, dass das Mittel eine oder mehrere Verbindungen der Formel (I) und/oder deren Salze enthält wie in einem der Ansprüche 1 bis 5 definiert, und ein oder mehrere weitere Stoffe ausgewählt aus den Gruppen (i) und/oder (ii), mit Plant growth regulator. A herbicidal and / or plant growth regulating agent, characterized in that the agent contains one or more compounds of the formula (I) and / or salts thereof as defined in any one of claims 1 to 5, and one or more further substances selected from the groups (i ) and / or (ii), with (i) ein oder mehrere weitere agrochemisch wirksame Stoffe, ausgewählt aus der Gruppe bestehend aus Insektiziden, Akariziden, Nematiziden, weiteren Herbiziden, Fungiziden, Safenern, Düngemitteln und/oder weiteren Wachstumsregulatoren,  (i) one or more further agrochemically active substances selected from the group consisting of insecticides, acaricides, nematicides, further herbicides, fungicides, safeners, fertilizers and / or further growth regulators, (ii) ein oder mehrere im Pflanzenschutz übliche Formulierungshilfsmittel.  (ii) one or more formulation aids customary in crop protection. Verfahren zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung von Pflanzen, dadurch gekennzeichnet, dass eine wirksame Menge A method of controlling harmful plants or regulating the growth of plants, characterized in that an effective amount einer oder mehrerer Verbindungen der Formel (I) und/oder deren Salzen, wie in einem der Ansprüche 1 bis 5 definiert, oder  one or more compounds of formula (I) and / or their salts as defined in any one of claims 1 to 5, or eines Mittels nach Anspruch 7,  a composition according to claim 7, auf die Pflanzen, Pflanzensamen, den Boden, in dem oder auf dem die Pflanzen wachsen, oder die Anbaufläche appliziert wird.  on the plants, plant seeds, the soil in which or on which the plants grow, or the cultivated area is applied.
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US11046660B2 (en) * 2016-09-28 2021-06-29 Mironid Limited Compounds and their use as PDE4 activators
US20210214311A1 (en) * 2018-09-28 2021-07-15 Shenzhen Edk Pharmaceutical Technology Co., Ltd. N-aromatic amide compunds, preparation methods and uses thereof
EP3858811A4 (en) * 2018-09-28 2022-05-11 Shenzhen EDK Pharmaceutical Technology Co., Ltd. N-AROMATIC AMIDE COMPOUND AND METHOD FOR THE PREPARATION AND USE THEREOF
US11760727B2 (en) 2018-09-28 2023-09-19 Shenzhen Edk Pharmaceutical Technology Co., Ltd. N-aromatic amide compounds, preparation methods and uses thereof

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