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WO2019052110A1 - Dispositif de perfusion de fluide et son mécanisme d'entraînement - Google Patents

Dispositif de perfusion de fluide et son mécanisme d'entraînement Download PDF

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Publication number
WO2019052110A1
WO2019052110A1 PCT/CN2018/074569 CN2018074569W WO2019052110A1 WO 2019052110 A1 WO2019052110 A1 WO 2019052110A1 CN 2018074569 W CN2018074569 W CN 2018074569W WO 2019052110 A1 WO2019052110 A1 WO 2019052110A1
Authority
WO
WIPO (PCT)
Prior art keywords
shape memory
driving
electrode
mechanism according
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2018/074569
Other languages
English (en)
Chinese (zh)
Inventor
黄霖
李鑫
刘宇程
罗志华
刘智勇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Shanghai Ltd
Medtronic Inc
Original Assignee
Medtronic Shanghai Ltd
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201710818473.6A external-priority patent/CN107469186B/zh
Priority claimed from CN201721165362.1U external-priority patent/CN209075694U/zh
Application filed by Medtronic Shanghai Ltd, Medtronic Inc filed Critical Medtronic Shanghai Ltd
Publication of WO2019052110A1 publication Critical patent/WO2019052110A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons

Definitions

  • the present invention relates to the field of fluid delivery, and in particular to a fluid infusion device and a drive mechanism therefor.
  • Diabetes is a metabolic disease characterized by high blood sugar.
  • Hyperglycemia is generally caused by defects in insulin secretion or its biological effects, or a combination of both.
  • the long-term presence of hyperglycemia in diabetic patients can cause chronic damage and dysfunction in multiple body organs (eg, eyes, kidneys, heart, blood vessels, nervous system, etc.).
  • Type 1 diabetes also known as insulin-dependent diabetes
  • Type 1 diabetes is usually a disease inherited by a congenital family.
  • Type 1 diabetes is an autoimmune disease in which the body's immune system attacks the beta cells that produce insulin in the body, ultimately leading to the inability to produce insulin in the body.
  • Such patients need to be injected with exogenous insulin to control blood sugar levels in the body.
  • Type 1 diabetes patients typically require 24-hour exposure to an electronic insulin pump, such as the Medtronic Minimed insulin pump.
  • Type 2 diabetes also known as non-insulin-dependent diabetes, is generally caused by adults, especially obese people, whose condition can lead to weight loss.
  • Possible causes include: insulin resistance, which prevents the body from using insulin effectively; the reduction in insulin secretion does not meet the body's needs.
  • Early type 2 diabetes patients can control and even cure diabetes by improving their lifestyles (eg, healthy eating, moderate exercise, safe weight loss, smoking cessation, and avoidance of secondhand smoke).
  • Most people with type 2 diabetes can control their blood sugar levels through oral hypoglycemic agents or control their blood sugar levels through a phased injection of insulin.
  • the traditional drug infusion device adopts a driving mechanism in which a motor and a screw are matched. For example, by rotating the lead screw by the motor, the lead screw is moved forward to drive the fluid pushing mechanism to push the fluid out of the reservoir.
  • a drive mechanism requires complicated motor components and transmission components, so that the overall production cost of the infusion device is increased and the weight is greatly increased.
  • the present invention provides a drive mechanism for a fluid infusion device that can be reused.
  • an embodiment of the present invention provides a drive mechanism for a fluid infusion device, comprising: a shape memory drive configured to generate a driving force by a shape change; and a transmission member having a stress dispersion portion And the stress dispersion portion is in contact with a portion of the shape memory drive member to disperse stress of the portion of the shape memory drive member during transmission of the driving force; and an output member opposite to the transmission member Cooperating, a fluid pushing mechanism for outputting the driving force to the fluid infusion device.
  • an embodiment of the present invention provides a fluid infusion device for administering a patient, the fluid infusion device comprising: a reservoir for storing a fluid; and an infusion line for Delivering fluid in the reservoir to a patient; a fluid pushing mechanism for pushing fluid in the reservoir for delivery to the patient through the infusion line; and a drive mechanism as previously described Driving the fluid pushing mechanism.
  • the transmission member have a stress dispersion portion to disperse the stress of the shape memory driving member, the small radius bending of the shape memory driving member can be avoided, the fatigue life of the shape memory driving member can be improved, and the driving mechanism can be increased.
  • the overall life span allows it to be reused in fluid infusion devices for extended periods of time.
  • FIG. 1 is a schematic view of a drive mechanism for a fluid infusion device in accordance with an embodiment of the present invention
  • Figure 2 is an enlarged schematic view showing the contact of the shape memory driving member and the stress dispersion portion of Figure 1;
  • Figure 3 is an enlarged plan view of the electrode of Figure 1;
  • FIG. 4 is a schematic view of a drive mechanism for a fluid infusion device in accordance with another embodiment of the present invention.
  • Figure 5a is an enlarged schematic view showing a contact portion of a shape of the stress dispersion portion and the shape memory driving member of Figure 4;
  • Figure 5b is a schematic view of the contact portion of Figure 5a after being glued
  • Figure 6a is an enlarged schematic view showing the contact of the stress dispersion portion of another shape of Figure 4 with the shape memory drive member;
  • Figure 6b is a schematic view of the contact portion of Figure 6a after being glued
  • Figure 7 is a schematic illustration of a fluid infusion device for administration to a patient in accordance with an embodiment of the present invention.
  • Embodiments of the present invention provide a drive mechanism for a fluid infusion device that can include, but is not limited to, a shape memory drive, a transmission component, and an output component.
  • the shape memory driving member can change the shape, and the driving force is generated by the shape change;
  • the transmission component is used for transmitting the driving force generated by the shape memory driving member; and
  • the output component is matched with the transmission component for outputting the driving force to the fluid transmission.
  • the transmission member has a stress dispersion portion that is in contact with a portion of the shape memory drive member to disperse stress of the portion of the shape memory drive member during transmission of the drive force.
  • FIG. 1 is a schematic view of a driving mechanism for a fluid infusion device according to an embodiment of the present invention
  • FIG. 2 is an enlarged schematic view of the shape memory driving member of FIG. 1 in contact with a stress dispersion portion
  • the drive mechanism 1 includes two shape memory drive members 11, a transmission member 12, and an output member 13, wherein the transmission member 12 has a stress dispersion portion 121, a stress dispersion portion 121, and a shape memory drive member 11. A portion of the contact contacts the stress of the portion of the shape memory drive during the transfer of the driving force.
  • the driving mechanism supplies electric power to the shape memory driving member 11 through the first electrode 14 and the second electrode 15, and heats and cools the shape memory driving member 11 by energizing and de-energizing to change the shape of the shape memory driving member 11.
  • the first electrode 14 is fixedly disposed on the transmission member 12, and the second electrode 15 is fixedly disposed at a position away from the transmission member 12.
  • each of the shape memory driving members 11 may be composed of a fixing portion for fixing the shape memory driving member 11 and a working portion for performing shape change, wherein the fixing portion is opposite An end portion, one end portion is fixedly connected to the first electrode 14, and the other end portion is fixedly connected to the second electrode 15; the working portion is a portion other than the opposite end portions, and the shape memory driving member is adjacent to the first electrode 14
  • the part is the working part, which surrounds the stress dispersion.
  • the stress dispersion portion 121 is a first circular arc surface 121 formed on the transmission member.
  • the circular arc surface is in contact with the working portion of the shape memory driving member to disperse the stress of the working portion, and during the shape change (shrinkage, elongation) of the shape memory driving member, the small radius of the working portion of the shape memory driving member can be avoided. Fold to improve its fatigue life.
  • the circular arc of the first circular arc surface may be any arc between 30 and 90 degrees, such as 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc., to better disperse the shape memory drive member. stress.
  • the shape memory driving member may be in the form of a wire, for example, formed of a shape memory alloy (for example, a nickel-titanium-niobium alloy), and provided with two, which are subjected to heat shrinkage and cooling elongation.
  • the shape memory driving member may also have other shapes, such as strips, strips, etc., or may be formed of other materials having shape memory properties, such as shape memory polymers, etc., the number of which is not limited to 2, for example, may be 1, 3, 4 or more, can be set according to the needs of the required driving force.
  • the first electrode and the second electrode each have a clamping portion that clamps the end of the shape memory driving member, and the clamping portion can be formed by sheet metal to better clamp the end of the shape memory driving member. Department, and achieve electrical conduction and fixation.
  • the first electrode and the second electrode may also fix the end of the shape memory driving member by other means, such as a direct adhesive connection or the like, or may form the clamping portion by other forms.
  • the end of the shape memory drive member may be fixed to the nip by gluing (at the adhesive portion shown in Fig. 1) to further increase the fixing effect while reducing the stress on the fixed portion.
  • the output member 13 is a ratchet
  • the transmission member 12 includes a shift fork 122 and a fork base 123.
  • the fork 122 is fixed to the fork base 123, and is operatively coupled to the ratchet 13, and the stress dispersion portion 121 is disposed on the fork base.
  • 123 is in contact with the shape memory drive member 11.
  • the output member may be other gears
  • the transmission member is not limited to the form of a shift fork, and may be any form capable of transmitting a driving force and cooperating with the output member.
  • the shape memory driving member 11 When the first electrode 14 and the second electrode 15 are energized, the shape memory driving member 11 is heated, and the working portion thereof is changed from the first shape to the second shape (for example, the length is shortened), and the first circle is passed through the working portion and the stress dispersion portion.
  • the contact of the arc surface 121 drives the fork base to rotate, so that the shift fork moves to push the ratchet to rotate one frame; when the first electrode 14 and the second electrode 15 are powered off, the shape memory driving member 11 is cooled, and the working portion thereof is The second shape is changed to the first shape (for example, the length is elongated), and the contact of the working portion with the first circular arc surface 121 of the stress dispersion portion drives the fork base to return to the original position, so that the shift fork is reset; Heating and cooling causes the ratchet to move intermittently, outputting motion and torque to the fluid pushing mechanism (see Figure 7).
  • the drive mechanism 1 further includes a reset member 16, which is coupled to the transmission member and configured to cause the shape memory drive member 11 to generate a driving force.
  • the shape is restored from the deformed shape to the shape before the deformation (returning from the second shape to the first shape, for example, elongating the shape memory drive member 11).
  • the reset member can be a reset torsion spring disposed on the fork base 123 to assist in elongating the shape memory drive member 11 to reset the shift fork when the shape memory drive member 11 is cooled.
  • FIG. 4 is a schematic view of a driving mechanism for a fluid infusion device according to another embodiment of the present invention
  • FIG. 5a is an enlarged schematic view showing a contact portion of a shape of the stress dispersion portion and the shape memory driving member of FIG.
  • Figure 5b is a schematic view of the contact in Figure 5a after being glued.
  • the drive mechanism 1' includes a shape memory drive member 11', a transmission member 12', and an output member 13', wherein the transmission member 12' has a stress dispersion portion, a stress dispersion portion, and a shape memory. A portion of the drive member 11' is in contact to dissipate the stress of the portion of the shape memory drive during the transfer of the drive force.
  • the driving mechanism supplies power to the shape memory driving member 11' through the first electrode 14' and the second electrode 15' to heat and cool the shape memory driving member 11' to change the shape of the shape memory driving member 11', the first electrode 14' And the second electrode 15' is fixedly disposed at a position away from the transmission member 12'.
  • the stress dispersion portion includes a first circular arc surface 121' formed on the transmission member and a retaining portion 124' formed at one end of the first circular arc surface, wherein the circular arc of the first circular arc surface It can be any arc between 30 and 90 degrees.
  • the shape memory driving member 11' is composed of a fixing portion for fixing the shape memory driving member 11' and a working portion for performing shape change, and the fixing portion includes opposite end portions and is supported in the middle of the surface of the holding portion 124' In one portion, one end is fixedly connected to the first electrode 14', the other end is fixedly connected to the second electrode 15', and the intermediate portion is fixed to the holding portion 124' so that the working portion of the shape memory driving member 11' is along the A circular arc surface 121' at least partially surrounds the transmission member 12'.
  • the shape material of the shape memory driving member 11' and the fixing manner of the opposite ends can be referred to the first embodiment, and details are not described herein.
  • the manner in which the shape memory driving member 11' and the holding portion 124' are fixed is as follows:
  • the surface of the holding portion 124' of the stress dispersion portion may be a circular arc surface (ie, a second circular arc surface) through which a portion of the shape memory driving member 11' in contact with the holding portion 124' may pass.
  • the gluing (adhesive area in Fig. 5b) is fixedly connected, and by the fixing of the glue, the stress of the shape memory driving member in contact with the surface of the holding portion can be reduced, making it difficult to bend.
  • the shape memory drive member may be otherwise secured to the surface of the retaining portion 124', such as a snap or the like.
  • the output member 13' is a ratchet
  • the transmission member 12' includes a shift fork 122' and a fork base 123'.
  • the shift fork 122' is fixed to the fork base 123', and is operatively coupled to the ratchet 13'.
  • the first circular arc surface 121' and the retaining portion 124' are both disposed on the fork base 123' to be in contact with the shape memory driving member 11'.
  • the output member may be other gears
  • the transmission member is not limited to the form of a shift fork, and may be any form capable of transmitting a driving force and cooperating with the output member.
  • the shape memory driving member 11' When the first electrode 14' and the second electrode 15' are energized, the shape memory driving member 11' is heated, and the working portion thereof is changed from the first shape to the second shape (for example, the length is shortened), and the working portion and the stress dispersion portion are passed through
  • the contact engagement of the first circular arc surface 121 ′ and the holding portion 124 ′ causes the shifting base to rotate, so that the shifting fork moves to push the ratchet to rotate one space; when the first electrode 14 ′ and the second electrode 15 ′ are powered off, The shape memory driving member 11' is cooled, and its working portion is changed from the second shape to the first shape (for example, the length is elongated), and the working portion is in contact with the first circular arc surface 121' and the holding portion 124' of the stress dispersion portion.
  • Cooperating, the fork base is restored to restore the original position, so that the fork is reset; by such circulation heating and cooling, the ratchet intermittently moves, and the movement
  • the drive mechanism may further include a reset member (not shown in FIG. 4) connected to the transmission member and configured to cause the shape memory drive member 11' recovers from the deformed shape to the shape before deformation during the generation of the driving force.
  • Fig. 6a is an enlarged schematic view showing the contact of the stress dispersion portion of the other shape in Fig. 4 with the shape memory driving member
  • Fig. 6b is a schematic view showing the contact at the contact portion of Fig. 6a.
  • the rest of the structure of the driving mechanism is the same as that of the second embodiment except for the shape of the holding portion of the stress dispersing portion.
  • the second embodiment and details are not described herein.
  • the surface of the holding portion 124' of the stress dispersion portion may be a rectangular surface.
  • the portion of the shape memory driving member 11' that is in contact with the holding portion 124' is fixedly joined by gluing.
  • the glue covers the rectangular surface of the holding portion, and the portion of the shape memory driving member 11' that is in contact with the holding portion 124' is completely wrapped in the glue, so that the glue can be fixed by the glue.
  • the stress on the contact of the shape memory drive member with the rectangular surface is reduced, making it difficult to bend.
  • Figure 7 is a schematic illustration of a fluid infusion device for administration to a patient in accordance with an embodiment of the present invention.
  • the fluid infusion device includes a reservoir 3, an infusion line 4, a fluid pushing mechanism 2, and a driving mechanism 1 (for example, the driving mechanism described in the first embodiment).
  • the accumulator 3 is used to store the fluid to be infused, and may be in various shapes, wherein the stored fluid may be various liquids or the like for administering to a patient.
  • the fluid can be a therapeutic liquid drug such as insulin.
  • the infusion line 4 is in communication with the reservoir 3 for delivering fluid in the reservoir to a target object (eg, a patient).
  • the fluid push mechanism 2 is used to push fluid in the reservoir 3 for delivery to the patient via the infusion line 4, which may include a piston that is axially movable in the reservoir 3 along the reservoir 3.
  • the drive mechanism 1 is used to drive a fluid pushing mechanism, for example, to move the piston axially in the reservoir 3 such that fluid in the reservoir 3 is delivered to the patient through the infusion line 4.
  • the fluid infusion device may replace the drive mechanism 1 with a drive mechanism 1' (e.g., the drive mechanism 1' described in the second embodiment or the third embodiment).
  • a drive mechanism 1' e.g., the drive mechanism 1' described in the second embodiment or the third embodiment.
  • the bending of the small radius of the memory alloy driving member can be avoided, the fatigue life can be improved, and the service life of the driving mechanism can be prolonged, so that the driving mechanism can be used for a long time.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un mécanisme d'entraînement (1, 1') pour un dispositif de perfusion de fluide, le mécanisme d'entraînement comprenant : un élément d'entraînement à mémoire de forme (11, 11') configuré pour générer une force d'entraînement au moyen de changements de forme; un composant de transmission (12, 12'), le composant de transmission (12, 12') ayant une partie de dispersion de contrainte (121, 121'), et la partie de dispersion de contrainte (121, 121') étant en contact avec une partie de l'élément d'entraînement à mémoire de forme (11, 11´) de façon à disperser la contrainte sur la partie de l'élément d'entraînement à mémoire de forme (11, 11') pendant le transfert de la force d'entraînement; et un composant de sortie (13, 13') coopérant avec le composant de transmission (12, 12') pour délivrer la force d'entraînement à un mécanisme de poussée de fluide (2) du dispositif de perfusion de fluide. Le mécanisme d'entraînement (1, 1') peut empêcher la flexion de petit rayon de l'élément d'entraînement à mémoire de forme (11, 11'), de telle sorte que la durée de vie en fatigue de l'élément d'entraînement à mémoire de forme (11, 11') est améliorée, et la durée de vie globale du mécanisme d'entraînement (1, 1') est prolongée.
PCT/CN2018/074569 2017-09-12 2018-01-30 Dispositif de perfusion de fluide et son mécanisme d'entraînement Ceased WO2019052110A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201710818473.6A CN107469186B (zh) 2017-09-12 2017-09-12 流体输注装置及其驱动机构
CN201721165362.1 2017-09-12
CN201721165362.1U CN209075694U (zh) 2017-09-12 2017-09-12 流体输注装置及其驱动机构
CN201710818473.6 2017-09-12

Publications (1)

Publication Number Publication Date
WO2019052110A1 true WO2019052110A1 (fr) 2019-03-21

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PCT/CN2018/074569 Ceased WO2019052110A1 (fr) 2017-09-12 2018-01-30 Dispositif de perfusion de fluide et son mécanisme d'entraînement

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WO (1) WO2019052110A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919167A (en) * 1998-04-08 1999-07-06 Ferring Pharmaceuticals Disposable micropump
US20030198558A1 (en) * 2002-04-22 2003-10-23 Nason Clyde K. Shape memory alloy wire driven positive displacement micropump with pulsatile output
CN1681544A (zh) * 2002-07-24 2005-10-12 M2医药有限公司 一种输液泵系统、输液泵组件及输液泵
CN101208515A (zh) * 2005-03-28 2008-06-25 因苏雷特公司 流体输送设备
US20090283377A1 (en) * 2008-05-15 2009-11-19 Roe Steven N Drug delivery pump drive using a shaped memory alloy wire
US20140350459A1 (en) * 2009-12-31 2014-11-27 Gregory R. Lanier, JR. Infusion Pump Assembly
CN104685210A (zh) * 2012-03-28 2015-06-03 维森楚私人有限公司 机械驱动器
CN107469186A (zh) * 2017-09-12 2017-12-15 美敦力公司 流体输注装置及其驱动机构

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919167A (en) * 1998-04-08 1999-07-06 Ferring Pharmaceuticals Disposable micropump
US20030198558A1 (en) * 2002-04-22 2003-10-23 Nason Clyde K. Shape memory alloy wire driven positive displacement micropump with pulsatile output
CN1681544A (zh) * 2002-07-24 2005-10-12 M2医药有限公司 一种输液泵系统、输液泵组件及输液泵
CN101208515A (zh) * 2005-03-28 2008-06-25 因苏雷特公司 流体输送设备
US20090283377A1 (en) * 2008-05-15 2009-11-19 Roe Steven N Drug delivery pump drive using a shaped memory alloy wire
US20140350459A1 (en) * 2009-12-31 2014-11-27 Gregory R. Lanier, JR. Infusion Pump Assembly
CN104685210A (zh) * 2012-03-28 2015-06-03 维森楚私人有限公司 机械驱动器
CN107469186A (zh) * 2017-09-12 2017-12-15 美敦力公司 流体输注装置及其驱动机构

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