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WO2019047989A3 - CRYSTALLINE FORMS OF (3α,5β,6α,7α)-6-ETHYL-3,7-DIHYDROXYCHOLAN-24-IC ACID - Google Patents

CRYSTALLINE FORMS OF (3α,5β,6α,7α)-6-ETHYL-3,7-DIHYDROXYCHOLAN-24-IC ACID Download PDF

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Publication number
WO2019047989A3
WO2019047989A3 PCT/CZ2018/000040 CZ2018000040W WO2019047989A3 WO 2019047989 A3 WO2019047989 A3 WO 2019047989A3 CZ 2018000040 W CZ2018000040 W CZ 2018000040W WO 2019047989 A3 WO2019047989 A3 WO 2019047989A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid
dihydroxycholan
ethyl
crystalline forms
crystalline form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CZ2018/000040
Other languages
French (fr)
Other versions
WO2019047989A2 (en
Inventor
Marketa Slavikova
Josef Zezula
Josef Cerny
Ondrej Dammer
Michal Simek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva KS filed Critical Zentiva KS
Publication of WO2019047989A2 publication Critical patent/WO2019047989A2/en
Publication of WO2019047989A3 publication Critical patent/WO2019047989A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Crystalline form J-1 and J-2 of obeticholic acid, whereas crystalline form J-1 shows characteristic reflections in an X-ray powder record using CuKα radiation: 6.3; 9.4; 12.2; 14.4; 16.5 and 19.0 ± 0.2° 2-theta and crystalline form J-2 shows characteristic reflections in an X- ray powder record using CuKα radiation: 6.3; 8.9; 10.8; 15.8; 16.5; 18.4 and 20.3 ± 0.2° 2-theta.
PCT/CZ2018/000040 2017-09-05 2018-08-31 CRYSTALLINE FORMS OF (3α,5β,6α,7α)-6-ETHYL-3,7-DIHYDROXYCHOLAN-24-IC ACID Ceased WO2019047989A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPUV2017-34072 2017-09-05
CZ2017-34072U CZ31099U1 (en) 2017-09-05 2017-09-05 The crystalline forms of (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxycholan-24-oic acid

Publications (2)

Publication Number Publication Date
WO2019047989A2 WO2019047989A2 (en) 2019-03-14
WO2019047989A3 true WO2019047989A3 (en) 2019-06-06

Family

ID=60084157

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2018/000040 Ceased WO2019047989A2 (en) 2017-09-05 2018-08-31 CRYSTALLINE FORMS OF (3α,5β,6α,7α)-6-ETHYL-3,7-DIHYDROXYCHOLAN-24-IC ACID

Country Status (2)

Country Link
CZ (1) CZ31099U1 (en)
WO (1) WO2019047989A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777836A (en) * 2015-04-09 2016-07-20 厦门蔚扬药业有限公司 Polymorphic substances of obeticholic acid and preparation method thereof
WO2017008773A1 (en) * 2015-07-16 2017-01-19 Zentiva, K.S. Crystalline forms of obeticholic acid
WO2017111979A1 (en) * 2015-12-22 2017-06-29 Intercept Pharmaceuticals, Inc. Polymorphic crystalline forms of obeticholic acid
WO2017167233A1 (en) * 2016-03-31 2017-10-05 江苏恒瑞医药股份有限公司 New crystalline form of obeticholic acid and preparation method therefor
WO2018211413A1 (en) * 2017-05-15 2018-11-22 Dr. Reddy’S Laboratories Limited Solid forms of obeticholic acid and process for preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777836A (en) * 2015-04-09 2016-07-20 厦门蔚扬药业有限公司 Polymorphic substances of obeticholic acid and preparation method thereof
WO2017008773A1 (en) * 2015-07-16 2017-01-19 Zentiva, K.S. Crystalline forms of obeticholic acid
WO2017111979A1 (en) * 2015-12-22 2017-06-29 Intercept Pharmaceuticals, Inc. Polymorphic crystalline forms of obeticholic acid
WO2017167233A1 (en) * 2016-03-31 2017-10-05 江苏恒瑞医药股份有限公司 New crystalline form of obeticholic acid and preparation method therefor
WO2018211413A1 (en) * 2017-05-15 2018-11-22 Dr. Reddy’S Laboratories Limited Solid forms of obeticholic acid and process for preparation

Also Published As

Publication number Publication date
WO2019047989A2 (en) 2019-03-14
CZ31099U1 (en) 2017-10-17

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