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WO2019043144A1 - Système de préservation fermé - Google Patents

Système de préservation fermé Download PDF

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Publication number
WO2019043144A1
WO2019043144A1 PCT/EP2018/073443 EP2018073443W WO2019043144A1 WO 2019043144 A1 WO2019043144 A1 WO 2019043144A1 EP 2018073443 W EP2018073443 W EP 2018073443W WO 2019043144 A1 WO2019043144 A1 WO 2019043144A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
airpipe
system container
distal
liquid chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/073443
Other languages
English (en)
Inventor
Kristian Iversen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ki Development Aps
Original Assignee
Ki Development Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ki Development Aps filed Critical Ki Development Aps
Publication of WO2019043144A1 publication Critical patent/WO2019043144A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/049—Valves integrated in closure

Definitions

  • This object can be achieved by offering closed systems, where the carcinogenic or damaging substances are added the samples, after a sample has safely been placed in a container, closed, and secured. Samples are then sent in closed system containers 20 to a laboratory for thorough analysis.
  • the container must be completely tight, safe, and offering sufficient fill of the container, as close to 100% as possible, to ensure that samples reach the laboratory unharmed.
  • this is achieved by decanting formaldehyde or any other preservation substance, from a closed container into another closed container in which the sample, for analysis, is placed.
  • a closed fluid transfer system having the features set forth in appended claim 1.
  • a system container for transferring fluid into a compatible sample container, the system container having a closed proximal end and a distal end defining a liquid chamber there between, wherein an airpipe is disposed inside the liquid chamber, the airpipe having a proximal orifice and a distal orifice.
  • the system container can be configured in a closed state and a fluid transfer state. In the closed state, the distal end of the system container is closed by means of a seal.
  • the seal In the fluid transfer state the seal is opened by means of actuation means and a distal portion of the liquid chamber is fluidly connected to the sample container and the airpipe fluidly connects a proximal portion of the liquid chamber to the sample container via the proximal orifice and the distal orifice.
  • Fig. 1 is a cross sectional view along a longitudinal axis of the fluid transfer system comprising a system container with adjoining sample container according to one embodiment of the present disclosure
  • Fig. 2 is a cross sectional detail view of the system in Fig. 1.
  • Fig. 3 is another cross sectional detail view of the system in Fig. 1 in an intermediate state
  • Fig. 4 is a further cross sectional detail view of the system of Fig.1 in a fluid transfer state.
  • Fig. 5 show a perspective upper view of the valve seat comprising outflow openings according to an embodiment.
  • Fig. 6 is a cross sectional detail view of notches of the sealing valve seat according to an embodiment.
  • Fig. 7 is a perspective cross sectional detail view of details of the system container in Fig. 1.
  • Fig.8 is a cross-sectional view of a fluid transfer system according to an embodiment.
  • Fig. 9 is a schematic illustration of further aspects of the sample container of the fluid transfer system according to the disclosure.
  • Fig.10 shows a cross sectional view of an embodiment of the fluid transfer system of the present disclosure.
  • Fig. 11 shows a cross sectional view of an embodiment of the fluid transfer system of the disclosure.
  • Fig. 12 shows a cross sectional view of an embodiment of the fluid transfer system of the disclosure.
  • the filling principle uses a valve 55, 58, 60, 70, 80.
  • an air channel such as an airpipe 50 that equalizes the pressure difference between the upper and lower container 20, 40.
  • an airpipe 50 is added to leverage the pressure, the liquid will not flow, if not shaken or otherwise forced forward. It is needed to combine the two containers 20, 40 with parallel flows of liquid and air, as no leverage to the open environment is allowed. At the same time, it needs to ensure, that there is no leakage from the system container 20 before use, in order to comply with shelf life demands.
  • the filling mechanism is solved by using a valve principle between the two containers 20, 40, having a small valve chamber 60 in between.
  • the proximal portion of the liquid chamber 23 of the system container 20 is connected to the valve chamber 60 by an airpipe 50 disposed coaxially along the central axis of the liquid chamber 26, and the distal bottom portion of the liquid chamber 24 is connected into the valve chamber 60 by outflow openings 73, which ensures the right balance between incoming air and outrunning liquid, to make the repositioning of air and liquid happen.
  • the valve 55, 58, 60, 80 and a return spring 91 or the like biasing means may ensure the automatic closing and tightness between the two containers 20, 40.
  • the system 10 is a 100% closed system to the outer environment, and offers complete tightness between the two containers 20, 40. In case the lower sample container 40 is filled with liquid, it offers maximum preservation security.
  • valve chamber 60 holds the same pressure as in the liquid chamber 26 inside the system container 20, and the difference pressure is situated across the valve member 55 and seal 58, but when the valve member 55 is forced open as can be derived i.a. from Fig. 4, and the valve opening 61 becomes larger than the area of outflow openings 73 as shown in Fig. 4 and 7, the pressure in the valve chamber 60 will drop to the pressure in the sample container 40.
  • the pressure difference is now situated across the outflow openings 73, and the fluid will pour into the sample container 40, only limited by the pressure difference between the liquid chamber 26 and the sample chamber 41 in the sample container 40, an inner diameter of the airpipe 50, and the area of the outflow openings 73.
  • an object of the present disclosure is filling the preservation container 100%.
  • the valve tightness after use is less important as it is placed inside the closed system 10. This is important when needing to handle increasing pressure in the sample container 40 caused by changing temperatures or altitude.
  • a potential pressure equalization may be handled by introducing small controlled passages or notches 82 as disclosed in Fig. 6 at the longitudinal valve seat 80 receiving the valve member 55 inside the system. These will give in, should pressure increase, and it will equalize the inside pressure between the chambers 26, 41.
  • the seal 58 which may be releasable seal such as an O-ring 58 will be forced out of position and be left on the lower edge of the valve seat 80 as illustrated in Fig. 3-4.
  • the force of a relatively weak return spring 91 or return means, and the inside pressure of the filled sample chamber 41 ensures sufficient tightness between the two containers 20, 40.
  • the O-ring 58 tightness will first give in where small notches 82 have been prepared in the valve seat 80. The unit 10 will still be completely tight to the outside environment.
  • One contemplated solution comprises a sample container 40 comprising a plastic bag 40' in combination with jars 40" or the like substantially rigid supporting part. Samples are in these cases placed in a plastic bag 40' as disclosed in Fig. 9 that are combined with the system container 20. However, instead of having one system container 20 for each sample size, the system container 20 will hold enough preservation liquid to surround samples entirely in matching plastic bags 40'. After placing the sample in the plastic bag 40', the bag is closed tight, and the valve 55, 80 activated, ensuring preservation of the sample. The full sample bag 40', and system container 20, is now tightly screwed on a suitable sized jar 40" that protects the sample bag 40' during transportation to the lab.
  • the jars 40" may come stabled together to save space and the lids may also be provided individually with the option of sterilizing only the component, which is in contact with the sample, should it be required.
  • the system container 20 for fluid transfer extends from a proximal end 21 to a distal end 22 and may comprise a hollow cylinder-shaped container, defining a liquid chamber 26 therein. Other suitable shapes may however be contemplated.
  • the proximal end 21, which is typically the upper end closest to the user, may be fluidly closed by a top part or an actuator 90.
  • the actuator 90 may thus firstly has the function of sealing the proximal end 21 and secondly to translate an actuation of the actuator 90 to a longitudinal and distally directed movement of the airpipe 50 disposed coaxially inside the system container 20.
  • the system container 20 may in preferred aspects comprise only one airpipe 50.
  • the actuator 90 may serve the purpose of stabilizing the airpipe 50 in terms of radial movement within the system container 20 such as to hinder dislodging, which potentially may cause leakage of preservation liquid stored in the liquid chamber 26.
  • the actuator 90 may comprise any means suitable for carrying out the prescribed function, however in a preferred aspect the actuator 90 may comprise a resilient member extending over the proximal end 21 and in some aspects close a proximal end of the airpipe 52.
  • the actuator 90 in the form of a resilient top may thus constitute a push button which act on airpipe 50 to cause the airpipe 50 to move in an actuating fluid transfer direction under the action of actuator 90 as a result of a user exerting force on the actuator e.g. to mechanically deform the actuator by means of an external force, such as a finger of a user, thereby displacing the airpipe 50 in a fluid transfer direction.
  • Actuation means may comprise the actuator 90 and the airpipe 50.
  • the airpipe 50 provides in one aspect a fluid channel between a bottom distal portion of the liquid chamber 24 to an upper proximal portion of the liquid container 23.
  • the airpipe 50 may thus, have a distal portion 49 adjacent the distal portion of the liquid chamber 24 and proximal portion 48 adjacent the proximal portion of the liquid container 23.
  • the airpipe 50 is connected to a valve member 55 and thus has a valve-opening function; the displacement of the airpipe 50 translating to an opening movement of the valve 55, 80 which will be explained herein.
  • the valve member 55 may practically correspond to a disc-shaped member extending radially outwards in a transverse direction from the closed distal end of the airpipe 51.
  • the valve member 55 may be formed as an integral part of the airpipe 50; in other words, an outer diameter of the airpipe distal end 51 may expand or protrude outwards in a transverse direction of the airpipe 50 to form the valve member 55.
  • the airpipe 50 function is activated when the valve 55, 80 is open, in particular when valve member 55 is displaced to a fluid transfer state.
  • the orifices 54 providing fluid connection between an interior of the airpipe 53 and across the airpipe to an exterior of the airpipe. In a closed state of the system container 20 the orifices 54 provide for transversally extending fluid connections between the interior of the airpipe 53 and the liquid chamber 26.
  • the orifices 54 facilitate that fluid may flow between the distal portion of the airpipe 49 to the proximal portion of the airpipe 48 and vice versa, and thus providing fluid connection between the distal portion of the liquid chamber 24 and the proximal portion of the liquid chamber 23 via the airpipe 50.
  • the system 10 according to the disclosure may thereby accomplish simultaneously flowing counter directed flows inside the system container 20; flow of a first fluid from the proximal portion of the liquid chamber 23 to the distal portion 24 and flow of a second fluid from the distal portion of the airpipe 49 to the proximal portion of the airpipe 48.
  • the bottom portion of the airpipe is the distal portion of the airpipe 49 and the upper portion of the airpipe is the proximal portion of the airpipe 48.
  • the displacement of the airpipe 50 will inherently also alter the location of the orifices 54 such that the orifices 54 may provide fluid communication between an exterior of the liquid chamber, such as the sample chamber 41 and the proximal portion of the liquid chamber 23.
  • the system container is in closed state wherein the distal orifice 54" is arranged in the liquid chamber 26, in particular the distal portion of the liquid container 24.
  • a transverse valve seat 70 is formed in the distal end of the system container 20 to mate with a proximal side of the valve member 56.
  • the valve seat 70 may typically be formed as an integral part of the distal end of the system container 22 or in close proximity of the distal end of the liquid container 22, protruding from the inner wall of the system container 25.
  • the valve seat 70 may in some embodiments extend from an inner wall 25 of the distal portion of the liquid chamber 24 in a transversal and radially centering direction.
  • the valve seat 70 has a centrally arranged aperture 47 for receiving the airpipe 50 therein. According to aspects at least part of the aperture of the valve seat 47 abuts the airpipe 50, thus providing i.a. radial fixation in relation to the system container 20.
  • a lower distal surface of the valve seat 72 is facing in a distal direction towards an opposing upper proximal surface of the valve member 56.
  • the distal surface of the valve seat 72 defines an internal valve chamber 60 together with the proximal surface of the valve member 56 and a lower distal section of the external surface of the airpipe 46 connecting to the valve member 55.
  • valve chamber 60 is rotational symmetric about the airpipe 50, forming a cylindrical chamber around the airpipe 50.
  • the valve chamber 60 may thus constitute a very small volume.
  • the volume of the valve chamber 60 upon displacement of the airpipe 50 in a distal direction towards a fluid transfer state of the system container 20, the volume of the valve chamber 60 thus increase as a consequence of a distance between the distal surface of the valve seat 72 and the proximal surface of the valve member 56 increasing.
  • the distal surface of the valve seat 72 may be substantially horizontal i.e. transverse or comprise a curved shape extending from the inner wall 25 of the system container 20 to the rim of the aperture 47, such as to exhibit hydrodynamic properties.
  • the system container 20 comprises a vertical, or substantially vertical i.e. longitudinal valve seat 80 disposed perpendicular the transverse valve seat 70 and facing an outer periphery of the disc-shaped valve member 57.
  • the valve member 55 may be slidingly received by the longitudinal valve seat 80 in a closed state of the system container 20.
  • the longitudinal valve seat 80 may however comprise a small angular offset in the range of 5-10 degrees in relation to a longitudinal direction such as to receive the seal, i.e. the O- ring 58.
  • the outer periphery of the valve member 57 comprises a the seal 58, such as an O-ring, washer, membrane or a gasket extending along the outer periphery of the valve member 57 and which seal the interspace between the longitudinal valve seat 80 and the valve member 55, thus the seal 58 may contact the inner wall of the system container 25 and/or the longitudinal valve seat 80 in sealing engagement to close the distal end of the system container 22, i.e. sealingly closing the distal end of the system container 22.
  • the longitudinal valve seat 80 may thus in preferred embodiments constitute the sealing valve seat of the system container 20.
  • seal 58 may alternatively be arranged on the proximal surface of the valve member 56 to rest on the distal surface of the transverse valve seat 72 in the closed state of the system container, thereby forming a sealing valve seat.
  • the longitudinal valve seat 80 may in addition comprise a circumferentially extending groove 81 or socket adapted to receive or mate with the seal 58 of the valve member.
  • the seal 58 may advantageously be arranged partially in a slit extending along the outer periphery of the valve member 57 so as to protrude out from the slit towards the longitudinal valve seat 80 in the closed state of the system container 20.
  • a potential pressure equalization over the sealing valve seat 80 may be handled by introducing small controlled passages or notches 82 as disclosed in Fig. 6 at the valve seat 80 inside the system. These will give in, should pressure increase, and it will equalize the inside pressure between the chambers 26 and 41.
  • the system container 20 being adapted to sealingly engage with a sample container 40 having a closed distal end.
  • the sample container 40 may comprise various shapes, this exemplary embodiment comprises a hollow cylinder-shaped container defining a sample chamber 41 therein.
  • the upper portion of the sample container comprises an inner thread 42 engaging with a corresponding outer thread 27 at a bottom portion of the system container 20, however other solutions are contemplatable such as a snap-in function or twist-lock function.
  • Figures 2 - 4 shows in sequence the general series of events of the system container 20 according to one aspect from a closed state in Figure 2 to a fluid transfer state in Figure 4.
  • the sample container 40 has been detachably attached to the system container 20 by the means for sealingly engaging the system container 20 with the sample container 40 to form a fluid tight system 10.
  • the valve member 55 is biased towards the transverse valve seat 70 and/or the longitudinal valve seat 80 by means of a return-spring 91 which may be threaded around the airpipe 50.
  • the return-spring 91 may rest against a proximal surface of the transverse valve seat 71 and may be threaded into the proximal orifice of the airpipe 54' or otherwise engage with the proximal orifice 54' or the return spring 91 may rest at it's upper end against notches protruding front he airpipe 50.
  • the return spring 91 may be substituted for, or complemented with other biasing means as will be explained herein.
  • the proximal orifice 54' may comprise the airpipe 50 having proximal end 52 which is open, where the open end constitutes the proximal orifice 54' of the airpipe 50, the open end fluidly communicating with the liquid chamber 26, in particular the proximal portion of the liquid chamber 23 but not the exterior of the system container 20.
  • the distal orifice of the airpipe 54" is at least partially disposed at a proximal side of the transverse valve seat 71.
  • the proximal surface of the valve member 56 may constitute a distal lower edge of the distal orifice 54" such that the proximal orifice 54" extends from the valve member 55 in a longitudinal and proximal direction.
  • the airpipe 55 has been displaced in a fluid transfer direction towards the fluid transfer state of the system container 20.
  • the distance between the distal surface of the transverse valve seat 72 and the proximal surface of the valve member 56 has increased whereby the volume of the internal valve chamber 60 has increased.
  • the distal orifice of the airpipe 54" is in this position extending between the liquid chamber 26 and the valve chamber 60, thereby allowing flow between the valve chamber 60 and the interior of the airpipe 53 and between the valve chamber 60 and the liquid chamber 26.
  • the system container 20 may comprise a storage seal (not shown) closing the edge of the distal end of the system container 22.
  • the storage seal may be a useful feature in such appliances where the system container 20 is stored absent a
  • the seal may thus be a manually removable seal such as a screw capsule or a seal which rupture under the action of the valve member 55 being displaced in a fluid transfer direction.
  • the transverse valve seat may 70 feature one or more outflow openings 73 constituting through holes in the transverse valve seat 70, as disclosed in Figure 5 and 7.
  • the transverse valve seat features at least two outflow openings 73 arranged symmetrically in the transverse valve seat 70.
  • the outflow openings 73 may be disposed in the valve member 55 such as not to be disposed adjacent the distal orifice 54" such that a flow through the outflow opening 73 is orthogonal a flow through the distal orifice 54".
  • Figure 4 shows a detail view of the internal valve 55, 58, 60, 70, 80 of the system container 20 in fluid transfer state wherein the valve member 55 has slid out of the longitudinal valve seat 80 whereby a fluid connection is established between the internal valve chamber 26 and the exterior or the system container 20, i.e. in this exemplary embodiment the sample container 40.
  • the whole valve member 55 protrudes out from the system container 20 to be disposed within the sample chamber 41 of the sample container 40.
  • valve member 55 is opened and no longer seals the space between the outer periphery of the valve member 57 and the longitudinal valve seat 80 at the distal end 22 of the system container 20.
  • the distal orifice of the airpipe 54" may be arranged to have a longitudinal extent extending from the valve member 55 to the transverse valve seat 70 and thus be positioned in the valve chamber 60. According to aspects, the distal orifice 54" extends no further than to the valve seat 70, thereby providing fluid connection exclusively between the valve chamber 60 and the interior of the airpipe 53.
  • At least a portion of the sample chamber 41 may have diameter being greater than a diameter of the valve member 55 so as to establish fluid connection between the valve chamber 60 and the sample chamber 41 via the valve opening 61.
  • 59 and the proximal and distal orifices 54', 54" may conveniently be calculated such as to provide the desired mass flow rate of preservation liquid from the liquid chamber 26 to the sample chamber 41.
  • the preservation fluid and the sample chamber 41 is filled with gaseous fluid, such compressible air having a density lower than that the preservation liquid, this configuration has a number of consequences. Firstly, the preservation fluid will flow under the action of gravity e.g. from the upper portion of the liquid chamber 23 in a distal direction to the bottom portion of the liquid chamber 24 and through the outflow openings 73 in the transverse valve seat 70 and into the valve chamber 60. Secondly, the preservation fluid will then continue to flow across the valve chamber 60 and over the valve member 55 to the edge or outer periphery 57 of the valve member and finally flow into the sample chamber 41 of the sample container 40 via the circumferential gap interspace between the longitudinal valve seat 80 and the valve member 55 forming the valve opening 61.
  • gaseous fluid such compressible air having a density lower than that the preservation liquid
  • the valve member 55 may comprise a breakable membrane such as to fluidly connect the liquid chamber 26 to the sample container 40 upon rupture of the membrane.
  • a breakable membrane such as to fluidly connect the liquid chamber 26 to the sample container 40 upon rupture of the membrane.
  • the seal 58 which may comprise an O-ring which does not rupture when the seal 58 is opened due to the movement of the airpipe 50 in a fluid transfer direction as has been explained.
  • the membrane may be broken by a suitable actuation means, such as an external member or an internal member for example a push-rod which may be acted on by actuator 90.
  • the internal member may in some embodiments be the airpipe 50.
  • one or more of the proximal- and/or distal orifices of the airpipe 54', 54" may comprise breakable or openable resealable seals in the form of membranes which in analogy are closed in the closed state of the system container 20 and are ruptured or opened in the fluid transfer state.
  • the gaseous fluid will be urged to flow from the sample container 40 due to the pressure difference created over the valve chamber 60 as the liquid fluid takes the place of the gaseous fluid. Accordingly, the air in the sample chamber 41 will flow into the distal orifice of the airpipe 54" and up the airpipe 50, thus flowing in a longitudinal and proximal direction opposite the flow direction of the preservation liquid in the liquid chamber 26. The airpipe 50 thus equalize the pressure difference over the valve chamber 60.
  • the proximal orifice of the airpipe 54' facilitates that the air may fill the void created in the upper portion of the liquid chamber 23 as preservation fluid flow therefrom.
  • FIG. 5 is a detailed view of the outflow openings 73 according to an exemplary embodiment of the disclosure.
  • the outflow openings 73 may comprise symmetrically arranged arc-shaped or circle-sector shaped through-holes 73.
  • the outflow openings 73 may extend radially from the centrally arranged aperture 47 of the valve member.
  • Preferred embodiments of the system container 20 may comprise a plurality of outflow openings, preferably two to four, more preferably two.
  • the valve member 55 features in addition also inflow and/or outflow openings to be disposed adjacent the distal orifices 54" of the airpipe when in a fluid transfer state, so as to facilitate the inflow of gaseous fluid from the valve chamber 60 to the liquid chamber 26 and/or the airpipe 50.
  • the transverse valve seat 70 may in addition comprise a series of radially extending baffles 94 or guiding fins as disclosed in Fig. 5, being arranged on the proximal side of the transverse valve seat 71 and on each side of the outflow openings 73 inter alia to inhibit swirl of the outflowing fluid.
  • the valve member 55 may comprise limiting means 59 adapted so as to limit the maximal distal movement of the airpipe.
  • limiting means may for example comprise mechanical limiting members or slits which may form integral protruding members of the valve member 55, and extending through the outflow openings 73 to engage with the transverse valve seat 70 e.g. by hooks or protrusions in a pre-determined end position of the airpipe 50 corresponding to the fluid transfer state.
  • the fluid flow across the outflow opening 73 is orthogonal a flow across the distal orifice 54".
  • the limiting members 59 extend from said valve member 55 through said outflow opening 73, wherein the fluid transfer state, the limiting members 59 engage with the transverse valve seat 70.
  • the actuator 90 is capable of translating an externally exerted force applied to the actuator 90 into a force acting on the airpipe 50.
  • the liquid chamber 26 contains a preservation fluid.
  • said seal 58 when in the closed state, said seal 58 is received in a circumferential groove 81 arranged on the inner wall of the distal end of the system container 25 receiving the valve member 55.
  • the circumferential groove 81 comprise notches 82 adapted to alleviate pressure difference over the seal 58 received by the groove 81.
  • a breakable seal (not shown) in addition closes the distal end of the liquid container 22, the seal being broken as a result of the airpipe 50 being displaced in a fluid transfer direction.
  • the actuator 90 comprises a resilient material extending over the proximal end of the system container 21 and a proximal end of the airpipe 52 to fluidly seal the proximal end of the system container 21 and/or the proximal end of the airpipe 52 and fixates the airpipe 50 in a radial direction of the system container 20.
  • FIG.8 A further embodiment of the invention is disclosed in Fig.8.
  • the description relating to the embodiments disclosed in Fig. 1-7 generally apply mutatis mutandis to the embodiment of Fig. 8 and vice versa unless otherwise is provided for.
  • the airpipe 150 is disposed stationary inside the system container 20 and the actuation movement which bring the system container 20 into a fluid transferring state is performed by means of a longitudinal push rod 196 extending inside the airpipe 150.
  • the airpipe 150 has a proximal orifice 154' in the form of an open proximal end, which is the upper end of the airpipe 150, and a distal orifice 154" in the form of a distal open end, which is the lower end of the airpipe 150.
  • the push rod 196 may mechanically connect to the valve member 55 featuring the discussed sealing means.
  • the seal 58 comprises a gasket abutting the lateral valve seat 70 and/or the longitudinal valve seat 80.
  • a longitudinal and distal movement of the push rod 196 opens the seal 58, thus establishing fluid communication between the distal lower portion of the liquid chamber 24 and the exterior of the system container i.e. the sample chamber 41, through an opening 197, and between the interior of the airpipe 150 and the exterior of the system container 20 i.e. the sample chamber 41 when the system container 20 is adapted to a sample container 40.
  • the actuation movement of the push rod 196 thus facilitate that liquid, such as preserving liquid held in the liquid chamber 126 will flow over the valve member 55 and into the sample chamber 41 in exchange for air held in the sample chamber 41 may rising into the system container 20; air flowing over the valve member 55 into the airpipe 150 and to an upper end of the air pipe or a proximal portion of the airpipe 48 and into the liquid chamber 26, typically a proximal portion of the liquid chamber 23.
  • the push rod 196 may comprise a cross-shaped cross-sectional profile allowing fluid, such as air, to flow between the push rod 196 and the interior of the airpipe 150.
  • the transverse valve seat 70 as disclosed in the embodiment of Fig. 8 is connects on one hand to the inner wall of the system container 25 and on one hand to the airpipe 150, forming the valve seat 70 there between.
  • the longitudinal valve seat 80 may thus be formed either as part of the inner wall of the inner wall of the system container 25 or the transverse valve seat 70 may connect to the inner wall of the system container 15 via the longitudinal valve seat 80 as shown in Fig. 8 wherein the longitudinal valve seat 80 is formed as an intermediate member between valve seat 70 and inner wall 25.
  • Fig. 8 further shows an embodiment of the actuator 90 having a corresponding function of a return spring in the form of a biased actuator 90.
  • the biased actuator 90 features a resilient profile, preferably a circumferential S-shaped resilient profile adjacent the inner rim of the system container 20 and connected to the push rod 196 or movable airpipe 50.
  • the actuator 90 being capable of acting on the push rod 196 or a movable non-stationary airpipe 50 to cause displacement of the same in a longitudinal and distal direction to open the seal 58 and capable of returning the push rod 196 or a movable non-stationary airpipe 50 in an opposite longitudinal and proximal direction, thereby causing the resealable seal 58 to reseal and thus close the system container 20.
  • This embodiment of the actuator 190 may be implemented in conjunction with any embodiment and can render the use of a return spring moot.
  • a return spring 91, 191 is not a necessity for proper function of any embodiment, Fig.8 however illustrate both the described actuator 90 and a return spring 191.
  • Actuation means may comprise the actuator 90 and the push rod 196. It should be noted that by a system container it is meant a universal container within the meaning of the system disclosed herein, the container typically containing preservation liquid and configured to cooperate with a variety of sample containers also within the meaning of the present disclosure.
  • a closed end should be understood as a fluid tight end allowing no fluid communication e.g. by means of sealing engagement between two entities.
  • proximal is to be understood as “towards the user” and distal as “away from the user”. Generally in this disclosure, proximal is synonymous with upper or top, and distal is synonymous with lower or bottom, provided the system is arranged standing vertically e.g. on a horizontal surface.
  • chamber is to be understood as a limited space within a structure, such as a container.
  • An airpipe as referred to herein is generally to be understood as a tube having an inner volume, capable of allowing a fluid flow there through.
  • An orifice is to be understood as a limited opening in a structure, such as a through-hole or an open end of a tube or airpipe.
  • a closed state of the system container is to be understood as a state wherein the system container is fluid tight, allowing no transfer of fluid from within the container to the exterior.
  • a fluid transfer state is a state of the system container wherein fluid is allowed to exit and enter the system container, thus in the fluid transfer state fluid is allowed to be repositioned within the closed system comprising the system container and the sample container.
  • a seal in not limited to comprise an element, such as an O-ring or gasket, but may also include as sealing function resulting from fluid tight engagement between two entities.
  • a seal which is opened is to be understood as two sealing entities disengaging to allow fluid communication there between.
  • Actuation typically comprises a movement and transfer of movement causing a change of state of the system container.
  • Actuation means may thus include interrelated moveable elements, fluidly connecting is to be understood as allowing fluid communication, which may be direct exclusive fluid communication, for example, fluid connection between a proximal portion of the liquid chamber to the sample container via the proximal orifice and the distal orifice may thus equate to direct fluid communication there between without the fluid having to flow through a distal portion of the liquid chamber.
  • Figs. 10-12 shows embodiments of the fluid transfer system 10 as explained with reference to Fig.
  • the air pipe 150 is provided at a greater distance from the push rod 196 and still at a distance from the inner walls of the system container 20. Thus, there is a greater circumferential space between the air pipe 50 and the push rod 196 extending there through.
  • the inner casing or jacket which forms the airpipe 150 is disposed approximately half-way between the push rod 196 and the inner walls of the system container 20. This entails that the transverse extension of the transverse valve seat 70 is reduced.
  • the return spring 191 may in some embodiments be omitted and the push rod 196 connect to the actuator 90, in particular the resilient member of the actuator 90 as illustrated in Figs. 10-12.
  • the opening 197 is formed in the air pipe 50, 150, in particular in a longitudinally extending distal portion of the air pipe 50, 150.
  • a longitudinal and distal movement of the push rod 196 opens the seal 58, thus establishing fluid communication between the distal lower portion of the liquid chamber 24 and the exterior of the system container i.e. the sample chamber 41, through an opening 197, and between the interior of the airpipe 50 and the exterior of the system container 20 i.e. the sample chamber 41 when the system container 20 is adapted to a sample container 40.
  • the distal orifice 154" is established between the air pipe 50, 150 and the transverse valve seat 70 and/or the longitudinal valve seat 80 by breaking of the seal 58 whereby the airpipe 50, 150 have a proximal orifice 154' and a distal orifice 154".
  • the proximal orifice 154" is formed between a proximal end portion of the air pipe 50 and the push rod 196.
  • the proximal end portion may comprise a bend inwards towards the push rod 196 and which may have the form of a right angle extending at least partially through the said space between the air pipe 50, 150 and the push rod 196.
  • the seal 58 may comprise a breakable bonding means comprising an applied glue or adhesive adapted to break under the action of a longitudinal and distal movement of the push rod 196.
  • the bonding means may be provided during manufacture and may be painted or brushed on to at least one of the edges and/or periphery of the valve member 55 and/or the seat 70, 80.
  • a peripheral portion of the valve member 55 and an inner rim of the seat 80 may comprise surface which constitute mating surfaces when the system container is in closed state.
  • the outer peripheral portion of the valve member 55 may comprises beveled edges which mate with corresponding beveled edges of the seat 80.
  • valve member 55 features a seal 58 which may be in the form of a gasket as has been explained herein in conjunction with Figs.1-8.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Un récipient de système pour transférer un fluide dans un récipient d'échantillon compatible, le récipient de système ayant une extrémité proximale fermée et une extrémité distale définissant une chambre de liquide entre celles-ci, un tuyau d'air étant disposé à l'intérieur de la chambre de liquide, le tuyau d'air ayant un orifice proximal et un orifice distal. Le récipient de système peut être configuré dans un état fermé et dans un état de transfert de fluide. Dans l'état fermé, l'extrémité distale du récipient de système est fermée au moyen d'un joint d'étanchéité. Dans l'état de transfert de fluide, le joint d'étanchéité est ouvert au moyen d'un moyen d'actionnement et une partie distale de la chambre de liquide est en communication fluidique avec le récipient d'échantillon et le tuyau d'air relie de manière fluidique une partie proximale de la chambre de liquide au récipient d'échantillon par l'intermédiaire de l'orifice proximal et de l'orifice distal.
PCT/EP2018/073443 2017-09-04 2018-08-31 Système de préservation fermé Ceased WO2019043144A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1751062-9 2017-09-04
SE1751062 2017-09-04

Publications (1)

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WO2019043144A1 true WO2019043144A1 (fr) 2019-03-07

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764046A (en) * 1971-12-09 1973-10-09 Ciba Geigy Corp Compressed air fluid product dispenser
US20040112923A1 (en) * 2001-05-10 2004-06-17 Tatsuo Tsutsui Gas injection valve and filling jig used for filling gas
KR20060017448A (ko) * 2004-08-20 2006-02-23 김길수 화장품 용기 및 이에 사용되는 펌핑장치
US20090084872A1 (en) * 2006-03-14 2009-04-02 Packaging Technology Participation Sa Actuator for a receptacle having a pressurized content and method for spraying a pressurized content
KR20100081776A (ko) * 2009-01-07 2010-07-15 정규천 공기 압축력을 이용한 내용물 분사식 용기

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764046A (en) * 1971-12-09 1973-10-09 Ciba Geigy Corp Compressed air fluid product dispenser
US20040112923A1 (en) * 2001-05-10 2004-06-17 Tatsuo Tsutsui Gas injection valve and filling jig used for filling gas
KR20060017448A (ko) * 2004-08-20 2006-02-23 김길수 화장품 용기 및 이에 사용되는 펌핑장치
US20090084872A1 (en) * 2006-03-14 2009-04-02 Packaging Technology Participation Sa Actuator for a receptacle having a pressurized content and method for spraying a pressurized content
KR20100081776A (ko) * 2009-01-07 2010-07-15 정규천 공기 압축력을 이용한 내용물 분사식 용기

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