WO2018217894A8 - Fluorine-labelled halichondrin derivatives and related methods of synthesis - Google Patents
Fluorine-labelled halichondrin derivatives and related methods of synthesis Download PDFInfo
- Publication number
- WO2018217894A8 WO2018217894A8 PCT/US2018/034132 US2018034132W WO2018217894A8 WO 2018217894 A8 WO2018217894 A8 WO 2018217894A8 US 2018034132 W US2018034132 W US 2018034132W WO 2018217894 A8 WO2018217894 A8 WO 2018217894A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluorine
- labelled
- synthesis
- related methods
- halichondrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to halichondrin derivatives containing fluorine, e.g., fluorine-18, as well as methods of synthesizing the same.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510350P | 2017-05-24 | 2017-05-24 | |
| US62/510,350 | 2017-05-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2018217894A1 WO2018217894A1 (en) | 2018-11-29 |
| WO2018217894A8 true WO2018217894A8 (en) | 2019-03-14 |
Family
ID=64395958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2018/034132 Ceased WO2018217894A1 (en) | 2017-05-24 | 2018-05-23 | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2018217894A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2830242C1 (en) * | 2020-01-22 | 2024-11-18 | Шанхай Сэньхой Медсин Ко., Лтд. | Eribulin derivative drug conjugate, method for preparation thereof and use thereof in medicine |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8093410B2 (en) | 2007-10-03 | 2012-01-10 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin B analogs |
| EP3689881B1 (en) | 2013-11-04 | 2022-01-12 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| RU2020141025A (en) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | MACROCYCLIZATION REACTIONS AND INTERMEDIATE COMPOUNDS AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF HALIKHONDRIN MACROLIDES |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| KR102404629B1 (en) | 2016-06-30 | 2022-06-02 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Prince Reaction and Intermediates Useful for Synthesis of Halicondine Macrolides and Analogs thereof |
| US11542269B2 (en) | 2018-01-03 | 2023-01-03 | Eisai R&D Management Co., Ltd. | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof |
| MX2022009044A (en) * | 2020-01-22 | 2022-08-11 | Shanghai Senhui Medicine Co Ltd | ERIBULIN DERIVATIVE DRUG CONJUGATE, METHOD OF PREPARATION AND APPLICATION OF THE SAME IN MEDICINE. |
| CN114380840B (en) * | 2022-01-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | Synthesis of eribulin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009064029A1 (en) * | 2007-11-16 | 2009-05-22 | Eisai R & D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| US9278979B2 (en) * | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| EP3689881B1 (en) * | 2013-11-04 | 2022-01-12 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| SG10201805024YA (en) * | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| EP3191479B1 (en) * | 2014-09-09 | 2020-04-08 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
-
2018
- 2018-05-23 WO PCT/US2018/034132 patent/WO2018217894A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2830242C1 (en) * | 2020-01-22 | 2024-11-18 | Шанхай Сэньхой Медсин Ко., Лтд. | Eribulin derivative drug conjugate, method for preparation thereof and use thereof in medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018217894A1 (en) | 2018-11-29 |
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