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WO2018200995A3 - Orthogonal polybiosensing and imaging systems - Google Patents

Orthogonal polybiosensing and imaging systems Download PDF

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Publication number
WO2018200995A3
WO2018200995A3 PCT/US2018/029864 US2018029864W WO2018200995A3 WO 2018200995 A3 WO2018200995 A3 WO 2018200995A3 US 2018029864 W US2018029864 W US 2018029864W WO 2018200995 A3 WO2018200995 A3 WO 2018200995A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
biological samples
polybiosensing
orthogonal
imaging systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2018/029864
Other languages
French (fr)
Other versions
WO2018200995A2 (en
Inventor
Mandana Veiseh
Pirooz Parvarandeh
S. Bahram Bahrami
Oliver Peter King-Smith
Todd S. Rutherford
Aaron Peter SCHELLENBERG
Timothy Scott Edward HILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polybiomics Inc
Original Assignee
Polybiomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomics Inc filed Critical Polybiomics Inc
Priority to CN201880042834.5A priority Critical patent/CN110799830B/en
Priority to EP18790804.1A priority patent/EP3615921A4/en
Publication of WO2018200995A2 publication Critical patent/WO2018200995A2/en
Publication of WO2018200995A3 publication Critical patent/WO2018200995A3/en
Priority to US16/664,537 priority patent/US11338294B2/en
Anticipated expiration legal-status Critical
Priority to US17/727,601 priority patent/US20220250056A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
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    • G01N29/024—Analysing fluids by measuring propagation velocity or propagation time of acoustic waves
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • G—PHYSICS
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    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
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    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.
PCT/US2018/029864 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems Ceased WO2018200995A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880042834.5A CN110799830B (en) 2017-04-27 2018-04-27 Orthogonal multi-biometric sensing and imaging system
EP18790804.1A EP3615921A4 (en) 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems
US16/664,537 US11338294B2 (en) 2017-04-27 2019-10-25 Orthogonal polybiosensing and imaging systems
US17/727,601 US20220250056A1 (en) 2017-04-27 2022-04-22 Orthogonal polybiosensing and imaging systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762491090P 2017-04-27 2017-04-27
US62/491,090 2017-04-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/664,537 Continuation US11338294B2 (en) 2017-04-27 2019-10-25 Orthogonal polybiosensing and imaging systems

Publications (2)

Publication Number Publication Date
WO2018200995A2 WO2018200995A2 (en) 2018-11-01
WO2018200995A3 true WO2018200995A3 (en) 2018-12-06

Family

ID=63918676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/029864 Ceased WO2018200995A2 (en) 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems

Country Status (3)

Country Link
EP (1) EP3615921A4 (en)
CN (1) CN110799830B (en)
WO (1) WO2018200995A2 (en)

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USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20230047769A1 (en) * 2020-02-19 2023-02-16 Sony Semiconductor Solutions Corporation Biological substance detection chip, biological substance detection device and biological substance detection system
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
KR102369697B1 (en) * 2020-05-18 2022-03-03 국민대학교산학협력단 Bio sensing module, and system including the same
EP3943924A1 (en) * 2020-07-22 2022-01-26 Technische Universität München Microwell plate for impedance measurements on cell clusters
US20240019404A1 (en) * 2020-10-15 2024-01-18 University Of Southern California System and method for high-frequency imaging array
CN112415002B (en) * 2020-11-10 2023-03-14 之江实验室 Multimode sensing device based on image sensor
CN114217208B (en) * 2021-12-10 2024-04-19 余姚舜宇智能光学技术有限公司 Module testing device and testing method of module testing device
CN114799495B (en) * 2021-12-28 2023-06-13 华中科技大学 A control method and related device for laser cutting
CN114821576A (en) * 2022-06-30 2022-07-29 之江实验室 Target identification method and device based on visual sense and olfactory sense device
CN116269305B (en) * 2023-03-17 2025-08-19 东南大学 Electrical impedance monitoring device, system and method for nematode exercise behavior
WO2025171043A1 (en) * 2024-02-05 2025-08-14 CytoTronics Measurement device reader systems
CN118813409A (en) * 2024-07-10 2024-10-22 海南大学 A neural tissue or brain organoid chip model and its construction method and application
CN119167974B (en) * 2024-08-27 2025-07-29 广州牛顿光学研究院有限公司 Multifunctional reusable counting plate design method based on modularization and related products

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JPH09281066A (en) * 1996-04-15 1997-10-31 Horiba Ltd Measuring system using impedance ct
US6426615B1 (en) * 1998-02-13 2002-07-30 Shailesh Mehta Apparatus and method for analyzing particles
US6132683A (en) * 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20040209351A1 (en) * 2001-08-30 2004-10-21 Hagen Thielecke Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
KR20160124013A (en) * 2015-04-16 2016-10-26 연세대학교 산학협력단 Biosensor for real-time monitoring 3D cell culture

Also Published As

Publication number Publication date
WO2018200995A2 (en) 2018-11-01
CN110799830A (en) 2020-02-14
EP3615921A2 (en) 2020-03-04
CN110799830B (en) 2023-04-14
EP3615921A4 (en) 2021-04-14

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