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WO2018138788A1 - Dispositif de détermination d'inhalation et unité d'inhalateur - Google Patents

Dispositif de détermination d'inhalation et unité d'inhalateur Download PDF

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Publication number
WO2018138788A1
WO2018138788A1 PCT/JP2017/002412 JP2017002412W WO2018138788A1 WO 2018138788 A1 WO2018138788 A1 WO 2018138788A1 JP 2017002412 W JP2017002412 W JP 2017002412W WO 2018138788 A1 WO2018138788 A1 WO 2018138788A1
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WO
WIPO (PCT)
Prior art keywords
inhaler
flow rate
flow path
air
inhalation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2017/002412
Other languages
English (en)
Japanese (ja)
Inventor
博一 三橋
惇紀 宮川
茂 加川
晶充 八子
真一 辰巳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denseisirius Co Ltd
Taisei Kako Co Ltd
Syntegon Technology KK
Original Assignee
Denseisirius Co Ltd
Taisei Kako Co Ltd
Bosch Packaging Technology KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denseisirius Co Ltd, Taisei Kako Co Ltd, Bosch Packaging Technology KK filed Critical Denseisirius Co Ltd
Priority to PCT/JP2017/002412 priority Critical patent/WO2018138788A1/fr
Publication of WO2018138788A1 publication Critical patent/WO2018138788A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the present invention relates to an inhalation determination device and an inhaler unit, and more particularly to an inhalation determination device used for an inhaler for inhaling powder medicine and an inhaler unit including the same.
  • Patent Document 1 discloses a counter used in an inhaler for inhaling powder medicine together with inhalation.
  • the counter has a flow path that communicates with the intake port of the inhaler, and detects flow rate information related to the flow rate of the intake air flowing through the flow path when the user inhales the powdered medicine together with the intake air. Based on this, it is determined whether the user has inhaled the powder normally.
  • a main object of the present invention is to provide an inhalation determination device and an inhaler unit including the same that can be suitably used for an inhaler having a plurality of air ports having different roles.
  • an inhalation determination device used in an inhaler for a user to inhale powder together with inhalation through an inhalation port that is taken in from a plurality of air ports having different roles and communicates with the plurality of air ports.
  • the inhalation determination device When the inhalation determination device is connected to the inhaler, a flow path communicating with any of the plurality of air ports and detection for detecting flow rate information related to the flow rate of the intake air taken into the inhaler through the flow path
  • An inhalation determination device is provided that includes a determination unit that determines whether or not the user has normally inhaled powder based on the flow rate information detected by the detection unit.
  • the inhaler includes a plurality of air ports having different roles, and an inhalation port communicating with the plurality of air ports, and the inhaler for the user to inhale powder medicine together with inhalation that is taken from the plurality of air ports and passes through the inhalation port, and inhalation
  • An inhalation determination device connected to the inhaler, wherein the inhalation determination device detects flow rate information relating to a flow path communicating with any of the plurality of air ports, and a flow rate of the intake air taken into the inhaler through the flow path.
  • An inhaler unit is provided that includes a detection unit and a determination unit that determines whether or not the user has normally inhaled the powder based on the flow rate information detected by the detection unit.
  • the inhalation determination device is connected to the inhaler so that any one of the plurality of air ports of the inhaler communicates with the flow path of the inhalation determination device.
  • the flow rate information regarding the flow rate of the intake air that is taken into the inhaler through the flow path of the inhalation determination device out of the inspiratory passage through the inhaler inlet during use Is determined. For example, if the flow rate information is larger than a predetermined value, it is determined that the user has inhaled the powder normally. On the other hand, if the flow rate information is less than the predetermined value, the powder has not reached the predetermined organ and is used. It is determined that the person is not inhaling the powder normally. In this way, even in an inhaler having a plurality of air ports having different roles, it can be determined whether or not the user has inhaled the powder normally.
  • a plurality of air ports of the inhaler include a first air port for taking in air for sucking up the powder held in the inhaler, and a second air port for taking in air for stirring the sucked-up powder.
  • a first air port for taking in air for sucking up the powder held in the inhaler and a second air port for taking in air for stirring the sucked-up powder.
  • An inhalation determination device can be suitably used for such an inhaler.
  • the flow path communicates with the first air port, and the flow rate of the intake air passing through the flow path is greater than the flow rate of the intake air taken in from the second air port.
  • the diameter of the flow path can be set smaller. Therefore, the inhalation determination device can be reduced in size.
  • the inhaler has a main body having a second air port, a mouthpiece attached to one end of the main body and having a suction port, and the main body so as to be rotatable relative to the main body in the circumferential direction. And a base having a first air port.
  • the first air port is provided in the base in the vicinity of the connection portion between the base and the main body, and the inhalation determination device is accommodated in the base. Is done.
  • the overall length of the inhaler unit obtained by connecting the inhalation determination device to the inhaler can be shortened.
  • the flow path includes a main flow path and a bypass flow path that is branched from the main flow path and has a lower intake air flow rate than the main flow path, and the detection unit detects the flow rate of the intake air flowing through the bypass flow path.
  • the detection unit can be made smaller and the inhalation determination device can be made smaller than in the case where only the main channel is provided without providing the bypass channel.
  • bypass channel is provided in the detection unit.
  • the bypass channel is provided in the detection unit.
  • flow rate information regarding the flow rate of intake air taken into the inhaler through the flow path means not only the flow rate of intake air taken into the inhaler through the flow path but also the inhaler through the flow path. It is a concept that includes information correlated with the flow rate of intake air, for example, the flow rate of intake air that passes through the suction port of the inhaler and the flow rate of intake air that passes through the bypass flow path included in the flow path.
  • an inhalation determination device and an inhaler unit including the same can be suitably used for an inhaler having a plurality of air ports having different roles.
  • FIG. 2 is an illustrative sectional view showing a XX section of FIG. 1. It is a disassembled perspective view which shows an inhaler. It is a perspective view which shows the inhalation determination apparatus. It is a top view which shows a base. It is a top view which shows a rotation measurement plate. It is sectional drawing which shows a stirring part. It is a block diagram which shows the electric constitution of an inhalation determination apparatus.
  • (A) is a perspective view which shows a sensor and a sensor support member
  • (b) is the top view. It is a cross-sectional solution figure which shows a sensor, a sensor support member, and a flow path. It is a sectional view solution figure showing an inhalation judging device. It is a graph which shows the correlation with the flow volume of the intake air which passes along an inlet, and the flow volume of the intake air taken in through an air port.
  • an inhaler unit 1 includes an inhaler 10a for a user to inhale powder together with inhalation, and an inhalation determination device 10b used for the inhaler 10a. Including.
  • the inhaler 10 a includes a main body 12, a base 14, an air filter 16, a rotary metering plate 18, a storage unit 20, a stirring unit 22, and a mouthpiece 24.
  • the inhaler 10a is a multi-dose dry powder inhaler for inhaling powder, and the powder is an asthma drug.
  • the main body 12 has a side wall 26, a flat plate portion 28, a shaft hole 30, a vent hole 32, an annular convex portion 34, and an air port 36.
  • the side wall 26 is formed in a cylindrical shape.
  • the flat plate portion 28 is formed in a disk shape perpendicular to the axial direction of the side wall 26 slightly below the center of the side wall 26 in the axial direction.
  • the shaft hole 30 is formed so as to penetrate the flat plate portion 28 in the center of the flat plate portion 28 and to be circular in plan view.
  • the ventilation hole 32 penetrates the flat plate portion 28 in the vicinity of the shaft hole 30 and is formed to be circular in plan view.
  • the annular protrusion 34 protrudes upward in the axial direction of the flat plate portion 28 from the flat plate portion 28 and is formed in an annular shape.
  • the air port 36 extends downward from the upper end portion of the side wall 26 and penetrates the side wall 26 in the radial direction of the side wall 26.
  • the air port 36 takes in the intake air B2 for stirring the powder medicine sucked up by the intake air B1 taken from the air port 48 described later.
  • the air port 36 corresponds to a second air port.
  • the base 14 is attached to the lower end of the main body 12 so as to be rotatable in the circumferential direction relative to the side wall 26 of the main body 12.
  • the projection 40 and the shaft 42 are provided.
  • the base body 38 is formed in a cylindrical shape and has a reduced diameter portion 44, an edge portion 46, and an air port 48.
  • the reduced diameter portion 44 is reduced in diameter in the upper part of the base body 38 as it goes upward in the axial direction of the base body 38.
  • the edge portion 46 protrudes inward in the radial direction of the base body 38 from the upper end portion of the reduced diameter portion 44 and is formed so as to be annular in plan view.
  • the air port 48 is formed inward in the radial direction of the edge 46 and is formed to be circular in plan view.
  • the air port 48 is provided in the base 14 in the vicinity of the connection portion between the base 14 and the main body 12.
  • the air port 48 takes in the intake air B1 for sucking up the powder held in the inhaler 10a.
  • the air port 48 corresponds to the first air port.
  • the convex portion 40 protrudes upward in the axial direction of the base body 38 from the upper end portion of the base body 38, and includes a side wall 50, a top plate portion 52, and a plurality of (four in this embodiment) vent holes 54.
  • the side wall 50 protrudes upward in the axial direction of the edge 46 from the inner periphery of the edge 46 and is formed in an annular shape.
  • the outer peripheral surface 50 a of the side wall 50 is formed to be slidable along the inner peripheral surface 26 a of the side wall 26 of the main body 12.
  • the top plate portion 52 is formed in a disc shape perpendicular to the axial direction of the side wall 50, and the outer peripheral portion thereof is connected to the upper end portion of the side wall 50.
  • the plurality of vent holes 54 are formed at substantially 90 degree intervals in the circumferential direction of the top plate portion 52. Each of the plurality of vent holes 54 penetrates the top plate portion 52 so as to be substantially rectangular in plan view.
  • the shaft portion 42 extends upward in the axial direction from the center of the top plate portion 52 and is rotatably inserted into the shaft hole 30 of the main body 12.
  • the shaft portion 42 has a cylindrical portion 56 and a plurality (four in this embodiment) of convex portions 58.
  • the column portion 56 is formed in a column shape extending in the axial direction of the top plate portion 52.
  • the plurality of convex portions 58 protrude outward in the radial direction of the cylindrical portion 56 from the outer peripheral surface of the cylindrical portion 56, and are formed at intervals of approximately 90 degrees in the circumferential direction of the cylindrical portion 56.
  • each of the plurality of convex portions 58 extends from the upper end portion in the axial direction of the cylindrical portion 56 to the lower end portion.
  • the air filter 16 is formed in a disc shape and is attached to the flat plate portion 28 so as to close the lower portion of the vent hole 32 of the main body 12.
  • the air filter 16 allows air to pass but prevents the powder from falling.
  • the rotary metering plate 18 is formed in a disc shape, and can rotate relative to the side wall 26 of the main body 12 together with the base 14 in the circumferential direction.
  • the rotary metering plate 18 has a shaft hole 60 and a metering hole 62.
  • the shaft hole 60 penetrates the rotary weighing plate 18 at the center of the rotary weighing plate 18 and has a plurality of (four in this embodiment) concave portions 64.
  • the plurality of recesses 64 are recessed outward in the radial direction of the rotary metering plate 18 at the outer peripheral portion of the shaft hole 60, and are formed at approximately 90 ° intervals in the circumferential direction of the rotary metering plate 18.
  • the shaft portion 42 is inserted into the shaft hole 60 so that each of the plurality of convex portions 58 is fitted in each of the plurality of concave portions 64. When the shaft portion 42 rotates, the plurality of convex portions 58 and the plurality of concave portions 64 are caught, and the rotary weighing plate 18 rotates.
  • the measuring hole 62 is formed so as to pass through the rotary measuring plate 18 in the vicinity of the shaft hole 60 and to be circular in plan view. In the state shown in FIG. 2, the measuring hole 62 communicates with the vent hole 32 of the main body 12.
  • the accommodating portion 20 is attached to the inside of the main body 12, and includes a side wall 65, a top plate portion 66, a vent hole 68, a cylindrical portion 70, a cylindrical portion 72, and an annular convex portion 74.
  • the side wall 65 is formed in a cylindrical shape and is fitted inside the annular convex portion 34 of the main body 12.
  • the top plate portion 66 is formed in a disc shape perpendicular to the axial direction of the side wall 65, and the outer peripheral portion thereof is connected to the upper end portion of the side wall 65.
  • the vent hole 68 is formed so as to pass through the top plate portion 66 and the cylindrical portion 70 outside the center of the top plate portion 66 and to be circular in plan view.
  • the cylindrical portion 70 extends in a cylindrical shape from the top plate portion 66 downward in the axial direction of the top plate portion 66.
  • the vent hole 68 communicates with the measuring hole 62 of the rotary measuring plate 18.
  • the cylindrical portion 72 has a hollow portion 76 that stores powdered medicine, and extends in a cylindrical shape from the top plate portion 66 toward the lower side in the axial direction of the top plate portion 66.
  • illustration of a powder medicine is abbreviate
  • the inner diameter of the cylindrical portion 72 (the diameter of the hollow portion 76) is formed larger than the inner diameter of the cylindrical portion 70 (the diameter of the vent hole 68).
  • the center of the hollow portion 76 is at a position moved 180 degrees in the circumferential direction of the side wall 65 from the center of the vent hole 68.
  • the hollow portion 76 communicates with the measuring hole 62.
  • the annular convex portion 74 projects from the outer peripheral portion of the top plate portion 66 in the axial direction of the top plate portion 66 and is formed in an annular shape.
  • the stirring unit 22 is attached to the upper end of the storage unit 20, and includes a side wall 78, a top plate unit 80, a vent hole 82, an annular projection 84, a cylindrical unit 86, It has a vent 88, a side wall 90 and a side wall 92.
  • the side wall 78 is formed in a cylindrical shape and is fitted inside the annular convex portion 74 of the housing portion 20.
  • the top plate portion 80 is formed in a disc shape perpendicular to the axial direction of the side wall 78, and the outer peripheral portion thereof is connected to the upper end portion of the side wall 78.
  • the ventilation hole 82 penetrates the top plate 80 at the center of the top plate 80 and is formed to be circular in plan view.
  • the annular convex portion 84 is formed in an annular shape so as to surround the vent hole 82 on the outer side in the radial direction of the vent hole 82, and protrudes upward from the top plate portion 80 in the axial direction of the top plate portion 80.
  • the cylindrical portion 86 is formed in a cylindrical shape having a substantially C-shaped cross section, and extends downward from the top plate portion 80 in the axial direction of the top plate portion 80 so as to communicate with the vent hole 82.
  • the ventilation hole 88 extends from the upper end portion in the axial direction of the side wall 78 to the lower end portion, and penetrates the side wall 78 in the radial direction of the side wall 78.
  • the side wall 90 is formed in a substantially arc shape in cross section, and connects the circumferential end 86a of the tubular portion 86 and the circumferential end 78a of the side wall 78.
  • the side wall 90 extends in the axial direction of the side wall 78 along the end portion 86a and the end portion 78a.
  • the side wall 92 is formed in a substantially arc shape in cross section, and connects the vicinity of the center in the circumferential direction of the side wall 90 and the side wall 78.
  • the side wall 92 extends in the axial direction of the side wall 78 along the side wall 78 and the side wall 90.
  • the mouthpiece 24 is attached to the upper end portion of the main body 12, and has a mouthpiece main body 94, a suction port 96, a cylindrical portion 98 and a cylindrical portion 100.
  • the mouthpiece body 94 includes an annular portion 102 and a suction portion 104.
  • the annular portion 102 is formed in an annular shape and is attached to the upper end portion of the side wall 26 of the main body 12.
  • the suction portion 104 extends from the upper end portion of the annular portion 102 so as to gradually become narrower in the axial direction of the annular portion 102.
  • the suction port 96 is formed so as to pass through the top plate portion 106 at the center of the top plate portion 106 of the suction portion 104 and be circular in plan view.
  • the suction port 96 communicates with the air port 36 and the air port 48 through each member.
  • the cylindrical portion 98 has a hollow portion 108 that communicates with the suction port 96, and extends downward from the top plate portion 106 in the axial direction of the suction port 96.
  • a lower end portion of the cylindrical portion 98 is fitted inward of the annular convex portion 84 of the stirring portion 22, and the hollow portion 108 communicates with the vent hole 82.
  • the cylindrical part 100 extends in a cylindrical shape downward from the ceiling part 106 of the suction part 104.
  • inhalation determination device 10b includes a device main body 110 which is formed in a columnar shape and whose upper portion is reduced in diameter upward. Inside the apparatus main body 110, a main channel 112 through which intake air passes is provided. The main channel 112 passes through the center of the apparatus main body 110 in the axial direction.
  • illustration of the sensor 122 and the sensor support member 124 which are mentioned later is abbreviate
  • the apparatus main body 110 (so that the main flow path 112 (flow path A (described later)) communicates with the air port 48 of the inhaler 10a and the intake air B1 passing through the flow path A is taken into the inhaler 10a from the air port 48.
  • the inhalation determination device 10b) is connected to the inhaler 10a.
  • the apparatus main body 110 is inserted into the base main body 38 and accommodated in the base main body 38. That is, the inhalation determination device 10 b is inserted into the base 14 and accommodated in the base 14. Further, the flow rate of the intake air B1 passing through the flow path A is set to be smaller than the flow rate of the intake air B2 taken from the air port 36.
  • the inhalation determination device 10b includes a microcomputer 114, a memory 116, an RTC (real time clock) 118, a power source 120, a sensor 122, and a buzzer 123.
  • a memory 116, an RTC 118, a power source 120, a sensor 122, and a buzzer 123 are connected to the microcomputer 114.
  • the microcomputer 114 includes a CPU, a memory, and the like (not shown), and the operation of the inhalation determination device 10b is controlled by the microcomputer 114.
  • the memory included in the microcomputer 114 stores a program for performing a control operation by the microcomputer 114.
  • the memory 116 stores a predetermined value for determining whether the user has inhaled the powder normally.
  • the predetermined value is a correlation between the flow rate of the intake air B1 taken from the air port 48 through the flow channel A (the main flow channel 112 and the bypass flow channel 144) and the flow rate of the intake air B passing through the suction port 96, It is set by paying attention to the flow rate of the intake air B necessary to reach a predetermined organ.
  • attention is paid to the bronchi as a predetermined organ, and in this embodiment, the flow rate of the inhalation B necessary for the powder to reach the bronchus is set to 60 L / min.
  • the predetermined value is set to 1.062 L / min.
  • the flow rate of the intake B is 60 L / min
  • the flow rate of the intake B2 is 58.938 L / min.
  • the ratio between the intake air B1 and the intake air B2 is 98.23: 1.77.
  • a battery is used as the power source 120.
  • the buzzer 123 informs whether or not inhalation is appropriate.
  • the apparatus main body 110 has a sensor support member 124 therein.
  • the sensor support member 124 is made of, for example, resin and is formed in a casing shape, and has a through hole 126 extending in the longitudinal direction.
  • the through hole 126 forms a part of the main channel 112.
  • the through hole 126 has two columnar cavities 128 and 130 and a columnar cavity 132 connecting the cavities 128 and 130.
  • the cavity part 132 is formed smaller in diameter than the cavity parts 128 and 130, and the cavity parts 128, 130 and 132 are formed coaxially.
  • the diameter of the cavities 128 and 130 is set to be smaller than the diameter of the air port 48 of the inhaler 10a, and the amount of suction is adjusted by the cavity 132.
  • the sensor 122 is attached to the recess 134.
  • the sensor 122 includes a bypass flow path forming member 140 and a sensor main body 142, and can detect a flow rate.
  • the sensor 122 is a thermal flow sensor.
  • the bypass flow path forming member 140 is made of, for example, a resin and is formed in a casing shape.
  • the bypass channel forming member 140 is provided with a bypass channel 144 that connects the through holes 136 and 138.
  • the main channel 112 and the bypass channel 144 are connected via the through holes 136 and 138.
  • a rectangular parallelepiped recess 146 is formed on the side surface of the bypass flow path forming member 140, and the sensor main body 142 is disposed in the recess 146.
  • the sensor body 142 detects the flow rate of the intake air flowing through the bypass flow path 144 located on the side thereof.
  • the flow path A includes a main flow path 112 formed in the apparatus main body 110 and a bypass flow path 144 branched from the main flow path 112 and formed in the sensor 122.
  • the flow rate of the intake air passing through the bypass flow channel 144 is set to be smaller than the flow rate of the intake air passing through the main flow channel 112. In this embodiment, the flow rate of the intake air passing through the bypass flow path 144 is set to be approximately 3% of the flow rate of the intake air passing through the cavity 132. Note that the bypass ratio (ratio of the flow rate of the bypass flow path 144 to the flow rate of the cavity 132) is set so that the maximum measured amount of intake air that can be measured by the sensor 122 flows to the bypass flow path 144 at the time of maximum suction. Is preferred.
  • the detection unit includes a microcomputer 114 and a sensor 122.
  • the microcomputer 114 corresponds to the determination unit. Since the flow rate of the intake air flowing through the bypass flow channel 144 and the flow rate of the intake air B1 flowing through the flow channel A are correlated (substantially proportional), the flow rate of the intake air flowing through the bypass flow channel 144 detected by the sensor 122 is The microcomputer 114 can convert the flow rate of the intake air B1 flowing through the flow path A. In this embodiment, the flow rate of the intake air B1 corresponds to “flow rate information relating to the flow rate of intake air taken into the inhaler through the flow path”.
  • the rotary measuring plate 18 when the base 14 is rotated 180 degrees, the rotary measuring plate 18 is also rotated 180 degrees together with the base 14, and the measuring hole 62 communicates with the hollow portion 76.
  • the powder medicine accommodated in the hollow portion 76 flows into the measurement hole 62 by gravity.
  • the powder that has flowed into the measuring hole 62 is a powder that the user should inhale with one inhalation. That is, by adjusting the size of the measuring hole 62 in advance, it is possible to easily extract the amount of powder to be inhaled in one inhalation.
  • the base 14 is further rotated 180 degrees, and the measuring hole 62 is communicated with the vent hole 68 of the housing portion 20 and the vent hole 32 of the main body 12 as shown in FIG. At this time, the powder is held by the air filter 16 so as not to fall downward.
  • the intake air B1 taken from the air port 48 is taken into the inhaler 10a through the flow path A.
  • the intake air B1 taken from the air port 48 passes through the plurality of vent holes 54 and then passes through the air filter 16.
  • the powder held on the air filter 16 is sucked up by the intake air B1 and moves to the agitating unit 22 through the vent hole 68 together with the intake air B1.
  • the intake air B ⁇ b> 2 taken from the air port 36 flows into the stirring unit 22 through the vent hole 88.
  • the powder and the intake air B1 moved to the agitation unit 22 are agitated by the intake air B2, and further flow toward the inside of the cylindrical portion 86 together with the intake air B2.
  • the particles When the powdered medicine is agitated by the inhalation B2, the particles are finely pulverized and easily reach the bronchi in the body.
  • the intake air B1 and the intake air B2 merge in the stirring unit 22 and become the intake air B.
  • the powder Inside the cylindrical portion 86, the powder is sucked upward toward the suction port 96 while swirling with the suction B. Then, the powder medicine is inhaled by the user through the suction port 96 together with the intake air B.
  • the user inhales the powdered medicine together with the intake B (intake B1 and intake B2) taken from the air port 36 and the air port 48 and passing through the intake port 96.
  • the flow rate of the intake air flowing through the bypass flow path 144 is detected by the sensor 122 within a predetermined time (for example, 5 msec).
  • the flow rate (L / min) of the intake air B1 passing through the flow path A per minute is converted by the microcomputer 114.
  • the microcomputer 114 compares the flow rate of the intake air B1 with a predetermined value, and determines that the user has normally inhaled the powder if the flow rate of the intake air B1 is greater than the predetermined value. On the other hand, if the flow rate of the intake air B1 is equal to or less than the predetermined value, it is determined that the user is not normally inhaling the powder.
  • the microcomputer 114 and the sensor 122 detect the flow rate of the intake air B ⁇ b> 1 that is taken into the inhaler 10 a through the flow path A among the intake air B that passes through the intake port 96. Further, the microcomputer 114 determines whether or not the user has normally inhaled the powder based on the flow rate of the intake air B1.
  • the buzzer 123 notifies whether or not the inhalation has been normally performed. For example, when the inhalation is normally performed, the buzzer 123 sounds OK (beep). On the other hand, when the inhalation is not normally performed, the buzzer 123 sounds NG (beeply).
  • the inhalation determination device 10b communicates with the inhaler 10a so that the air port 48 of the inhaler 10a communicates with the flow path A of the inhalation determination device 10b. Connected. Then, the user normally inhales the powder medicine based on the flow rate of the intake air B1 that is taken into the inhaler 10a through the flow path A of the inhalation determination device 10b among the inhalation air B that passes through the intake port 96 of the inhaler 10a during use. It is determined whether or not. In this embodiment, based on the comparison between the flow rate of the intake air B1 and a predetermined value, it is determined whether the user has normally inhaled the powder.
  • the flow rate of the inhalation B1 is greater than a predetermined value, it is determined that the user has inhaled the powder normally.
  • the flow rate of the inhalation B1 is equal to or lower than the predetermined value, the powder is in a predetermined organ (in this embodiment, bronchi It is determined that the user has not inhaled the powder normally. In this way, even if the inhaler 10a has a plurality of air ports 36 and 48 having different roles, it can be determined whether or not the user has normally inhaled the powder.
  • the inhalation determination device 10b (inhaler unit 1) detects the flow rate of the intake air B1 that passes through the flow path A of the inhalation determination device 10b (that is, before the powdery medicine is mixed), so the sensor 122 is not contaminated by the powdery medicine. There is no problem in measurement. Therefore, it is possible to obtain the inhalation determination device 10b and the inhaler unit 1 including the same, which can be suitably used for the inhaler 10a having the plurality of air ports 36 and 48 having different roles.
  • the inhalation determination device 10b can be suitably used for such an inhaler 10a.
  • the flow path A In order to take in the intake air B1 passing through the flow path A from the air port 48, the flow path A communicates with the air port 48, and the flow rate of the intake air B1 passing through the flow path A is higher than the flow rate of the intake air B2 taken in from the air port 36. Few. In this case, since the flow rate of the intake air passing through the flow path A can be reduced as compared with the case where the flow path A is communicated with the intake port 36, the diameter of the flow path A can be set smaller. Therefore, the inhalation determination device 10b can be reduced in size.
  • the inhalation determination device 10b By housing the inhalation determination device 10b in the base 14, the entire length of the inhaler unit 1 obtained by connecting the inhalation determination device 10b to the inhaler 10a can be shortened. Further, the inhalation determination device 10b can be easily accommodated in the base 14 simply by being inserted into the base 14.
  • bypass channel 144 and the main channel 112 are included as the channel A, the pressure loss can be reduced as compared with the case of the bypass channel 144 alone. Further, the sensor 122 can be made smaller and the inhalation determination device 10b can be made smaller than the case where only the main flow path 112 is provided without providing the bypass flow path 144.
  • bypass flow path 144 is provided in the sensor 122, when it is desired to change the size (flow rate) of the bypass flow path 144, it can be easily handled by simply replacing the sensor 122.
  • the microcomputer 114 converts the flow rate of the intake air B1 passing through the flow path A detected by the microcomputer 114 and the sensor 122 into the flow rate of the intake air B passing through the suction port 96, and compares the obtained flow rate of the intake air B with a predetermined value. Based on the above, it may be determined whether the user has inhaled the powder normally.
  • the flow rate of the intake air B1 is converted into the flow rate of the intake air B based on the correlation between the flow rate of the intake air B passing through the suction port 96 and the flow rate of the intake air B1 passing through the flow path A shown in FIG.
  • the flow rate of the intake air B obtained by conversion corresponds to “flow rate information regarding the flow rate of the intake air taken into the inhaler through the flow path”.
  • the predetermined value corresponds to the flow rate of the inhalation B that passes through the inlet 96 necessary for the powder medicine to reach a predetermined organ in the body. For example, if the flow rate of the intake B obtained by conversion is larger than a predetermined value, it is determined that the user has normally inhaled the powder, while the flow rate of the intake B obtained by conversion is less than the predetermined value. If so, it is determined that the powder has not reached the predetermined organ and the user has not inhaled the powder normally.
  • the microcomputer 114 may determine whether or not the user has normally inhaled the powder based on a comparison between the flow rate of the intake air passing through the bypass flow path 144 detected by the sensor 122 and a predetermined value. .
  • the flow rate of the intake air flowing through the bypass flow path 144 has a correlation with the flow volume of the intake air B1 passing through the flow path A, it corresponds to “flow rate information regarding the flow rate of intake air taken into the inhaler through the flow path”. To do.
  • the predetermined value is a correlation between the flow rate of the intake air flowing through the bypass flow channel 144 and the flow rate of the intake air B1 passing through the flow channel A, the correlation between the flow rate of the intake air B1 and the flow rate of the intake air B passing through the suction port 96, and It is set by paying attention to the flow rate of the inhalation B necessary to reach a predetermined organ in the body. For example, if the flow rate of the intake air passing through the bypass flow path 144 is larger than a predetermined value, it is determined that the user has normally inhaled the powder, while the flow rate of the intake air passing through the bypass flow path 144 is less than the predetermined value. For example, it is determined that the powder has not reached the predetermined organ and the user has not inhaled the powder normally.
  • a predetermined value or the like may be changed by an input from the communication device (external terminal) to the inhalation determination device 10b.
  • the inhaler 10a is an inhaler for inhaling an asthma drug, and a predetermined value is set by paying attention to the inspiratory flow rate required for the asthma drug to reach the bronchi. It is not limited to this.
  • the predetermined value is set by paying attention to the flow rate of inhalation necessary for the powder to reach the lungs.
  • a predetermined value is set in accordance with the organ on which the powder medicine acts (the powder powder should reach), focusing on the flow rate of the intake air necessary for the powder medicine to reach the organ.
  • the inhalation determination device 10b is connected to the inhaler 10a so that the flow path A communicates with the air port 48
  • the inhalation determination device may be connected to the inhaler 10a so that the flow path of the inhalation determination device having the same structure as the inhalation determination device 10b communicates with the air port 36. In this case, whether or not the user has normally inhaled the powder is determined based on the flow rate information regarding the flow rate of the intake air B2.
  • each air port 36 (second air port) is formed has been described.
  • the present invention is not limited to this, and a plurality of second air ports may be formed.
  • an inhalation determination device having the same structure as the inhalation determination device 10b may be provided for each second air port.
  • the total amount of intake air introduced from the plurality of second air ports can be obtained by summing the flow rates of intake air passing through the flow paths obtained for each inhalation determination device.
  • each of the second air ports may be connected by a strip-shaped manifold, and an inhalation determination device having a structure similar to that of the inhalation determination device 10b may be provided at the inlet of the manifold.
  • the plurality of air ports having different roles has the air port 48 (first air port) and the air port 36 (second air port) is described, but the present invention is not limited to this.
  • the plurality of air ports having different roles may further include air ports having different roles from the air ports 48 and 36.
  • the inhalation determination device 10b is accommodated so as not to protrude from the base 14, but is not limited thereto.
  • the inhalation determination device 10b may be accommodated in the base 14 so that a part thereof protrudes from the base 14. In this case, the inhaler 10a can be easily attached to and detached from the inhaler 10a.
  • bypass flow path 144 is provided in the sensor 122 , but the present invention is not limited to this.
  • the bypass channel may be provided in a member different from the sensor.
  • the present invention is not limited to this. Instead of providing the bypass flow path 144, the sensor may detect the flow rate of the intake air B1 flowing through the main flow path 112 (flow path A).
  • each of the plurality of vent holes 54 formed in the base 14 is substantially rectangular in plan view
  • the present invention is not limited to this.
  • the plurality of air holes formed in the base may be formed in a circular shape, a triangular shape, or the like in plan view, and may have a size that does not provide the minimum flow resistance.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne une unité d'inhalateur 1 qui est pourvue d'un inhalateur 10a et d'un dispositif de détermination d'inhalation 10b. L'inhalateur 10a comprend des évents 36 et 48 ayant des rôles différents et une entrée 96 qui communique avec les évents 36 et 48, et est utilisé par un utilisateur pour inhaler un médicament en poudre conjointement avec de l'air inhalé B qui est prélevé à partir des évents 36 et 48 et traverse l'entrée 96. Le dispositif de détermination d'inhalation 10b est pourvu d'un canal A, d'un micro-ordinateur 114 et d'un capteur 122. Le canal A communique avec l'évent 48 lorsque le dispositif de détermination d'inhalation 10b est raccordé à l'inhalateur 10a, et le micro-ordinateur 114 et le capteur 122 détectent un volume d'écoulement d'air inhalé B1 qui est admis dans l'inhalateur 10a en traversant le canal A. Le micro-ordinateur 114 détermine si l'utilisateur a inhalé normalement ou non le médicament en poudre sur la base du volume d'écoulement détecté de l'air inhalé B1 traversant le canal A.
PCT/JP2017/002412 2017-01-24 2017-01-24 Dispositif de détermination d'inhalation et unité d'inhalateur Ceased WO2018138788A1 (fr)

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PCT/JP2017/002412 WO2018138788A1 (fr) 2017-01-24 2017-01-24 Dispositif de détermination d'inhalation et unité d'inhalateur

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12427270B2 (en) 2019-11-18 2025-09-30 Vectura Delivery Devices Limited Inhaler for use with a compliance monitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009532189A (ja) * 2006-04-05 2009-09-10 マイクロドース セラピューテクス，インコーポレイテッド 可変量の薬剤を供給する吸入装置
JP2016087169A (ja) * 2014-11-06 2016-05-23 大成化工株式会社 カウンタ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009532189A (ja) * 2006-04-05 2009-09-10 マイクロドース セラピューテクス，インコーポレイテッド 可変量の薬剤を供給する吸入装置
JP2016087169A (ja) * 2014-11-06 2016-05-23 大成化工株式会社 カウンタ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12427270B2 (en) 2019-11-18 2025-09-30 Vectura Delivery Devices Limited Inhaler for use with a compliance monitor

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