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WO2018130036A1 - Système de détection de qualité de sommeil à couplage cardiopulmonaire à capteurs multiples et procédé de détection correspondant - Google Patents

Système de détection de qualité de sommeil à couplage cardiopulmonaire à capteurs multiples et procédé de détection correspondant Download PDF

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Publication number
WO2018130036A1
WO2018130036A1 PCT/CN2017/115780 CN2017115780W WO2018130036A1 WO 2018130036 A1 WO2018130036 A1 WO 2018130036A1 CN 2017115780 W CN2017115780 W CN 2017115780W WO 2018130036 A1 WO2018130036 A1 WO 2018130036A1
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Prior art keywords
signal
sensor
electrocardiographic
sleep
analog
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Ceased
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PCT/CN2017/115780
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English (en)
Chinese (zh)
Inventor
冯雪
陈毅豪
陆炳卫
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Tsinghua University
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Tsinghua University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30—Input circuits therefor
    • A61B5/307—Input circuits therefor specially adapted for particular uses
    • A61B5/308—Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30—Input circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4815—Sleep quality
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A61B5/721—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7242—Details of waveform analysis using integration

Definitions

  • the invention relates to a flexible electronic device technology, in particular to an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor and a detecting method thereof.
  • a syndrome is a sleep disorder in which breathing stops during sleep. The most common cause is obstruction of the upper airway, often ending with loud snoring, body twitching or arm twitching. Up to 98% of patients with sleep apnea will have snoring, usually with complications such as hypertension, myocardial infarction, myocardial hypoxia, and stroke. Even if you have enough time to sleep, you are still very tired and have serious health problems. According to the survey, the incidence of sleep apnea syndrome in foreign countries is 2% to 4%.
  • Various physiological sensors are used to monitor and record various physiological parameters during sleep. EEG, ECG, ECG, EOG, EMG EMG are recorded and analyzed. Anaesthesia of sleep breathing parameters such as chest-abdominal breathing, snoring, pulse, blood oxygen saturation, pulse wave, respiratory rate, and body position.
  • the polysomnography monitor needs to arrange many leads at various positions of the human body such as the mouth, nose, jaw, chest, legs, fingers, which will cause great harm to the sleep of the monitored patient.
  • Comfort the subject's sleep quality is reduced or even can not sleep; at the same time, the polysomnography is large, only suitable for use in hospitals, can not detect the sleep state of patients in different sleep environments.
  • Xiaomi's millet bracelet measures the movement of the body and upper limbs during sleep by the accelerometer, and uses the time of rest of the limb as the sleep time to further analyze the quality and state of sleep.
  • the millet bracelet is simple in equipment, low in cost, and has little influence on the sleep mode, it can only distinguish between sleep state and awake state, and cannot analyze the apnea condition.
  • Sleepace's Reston Smart Sleep Monitor judges sleep by measuring the heartbeat, breathing, turning over, and leaving the bed by placing the monitor under the sleeper. Although this smart sleep monitor does not require direct contact with the human body, It reduces the impact on sleep conditions, but it is a passive measurement, the measurement data is single, and the apnea cannot be judged.
  • the present invention proposes a cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor and a detecting method thereof.
  • the cardiopulmonary coupled sleep quality detecting system based on the ultra-thin flexible strain and electrocardiographic sensor of the invention comprises: a strain sensor, an electrocardiographic sensor, an analog to digital conversion circuit, an amplifying circuit, a filtering circuit, a microprocessor, a wireless transmission unit and a mobile terminal
  • the strain sensor and the ECG sensor are ultra-thin flexible sensors
  • the strain sensor is attached to the surface of the chest
  • the two ECG electrodes of the ECG sensor are respectively attached to the surface under the left chest
  • the strain sensor and the three The resistors with constant resistance form a Wheatstone bridge, and the two outputs of the Wheatstone bridge are electrically connected to the analog-to-digital conversion circuit
  • the ECG sensor is electrically connected to the analog-to-digital conversion circuit
  • the circuit and the microprocessor are electrically connected to form a signal acquisition and processing unit; the signal acquisition processing unit and the wireless transmission unit are electrically connected and integrated on
  • the analog-to-digital conversion circuit and the temperature compensation of the Wheatstone bridge are used to eliminate the influence of the body temperature and the ambient temperature change on the measurement of the chest undulation by the variable sensor; the beating of the heart causes a potential difference between the two electrodes of the ECG sensor.
  • the electrocardiographic signal is transmitted to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into digital signals respectively; the amplifying circuit amplifies the signal; the respiratory signal is directly recorded by the microprocessor through the filtering circuit; The electric signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit; The cardiopulmonary coupling algorithm is used to calculate the mutual power spectrum and coherence of the ECG signal and the respiratory signal, and the sleep state is determined, and the result is wirelessly transmitted to the mobile terminal through the wireless transmission unit for recording and display.
  • the strain sensor adopts a structure of a foil strain gauge, which comprises a bonding layer, a flexible substrate, a polymer protective layer, a device layer and a packaging film; wherein the flexible substrate and the packaging film are made of a biocompatible film; the bonding layer is directly contacted and bonded On the skin, high-viscosity bio-adhesive can effectively bind to the skin without causing allergic reactions to the skin; forming a flexible substrate on the bonding layer to carry the above device; forming a rigid polymer on the flexible substrate
  • the protective layer bears the deformation transmitted by the flexible substrate, reduces damage to the device layer, and functions to protect the device layer; forms a device layer on the polymer protective layer, and the device layer is a patterned metal film, which is malleable According to different functions, it is designed into different pattern shapes, and is designed to be malleable fractal structure to realize ductility; a package film is formed on the device layer, and the device is packaged as a whole.
  • the undulation of the chest cavity is transmitted to the protective layer through the flexible substrate, causing deformation of the protective layer, thereby stretching or compressing the device layer, so that the resistance of the device layer occurs.
  • the change causes the Wheatstone bridge that is composed of the strain sensor and the three fixed resistors to be unbalanced.
  • the output current is output through the two outputs of the Wheatstone bridge as a respiratory signal, and the body temperature is removed by the effect of the Wheatstone bridge.
  • the variable sensor measures the influence of chest undulation corresponding to the change of ambient temperature, and the frequency and amplitude of breathing are obtained by the output current.
  • the biocompatible film provides breathability, water repellency and low sensitization to provide biocompatibility for the entire device, enabling the strain sensor to work on the human body for up to 24 hours.
  • the package film also uses a biocompatible film to protect the functional device. The structure is complete and the circuit function and biocompatibility are not destroyed by external liquids.
  • the electrocardiographic sensor comprises two electrocardiographic electrodes, a serpentine lead wire and a connecting end; wherein the two electrocardiographic electrodes have a distance therebetween; the two electrocardiographic electrodes are respectively connected to the connecting end by a ductile serpentine lead wire; The end is connected to the input end of the analog-to-digital conversion circuit; each of the electrocardiographic electrodes adopts a grid structure, and the lines forming the grid are curved serpentine lines, so that the electrocardiographic electrodes are malleable, and are not attached to the surface of the human body. It will be damaged by skin deformation; the beating of the heart causes a potential change, and a potential difference is generated between two ECG electrodes having a certain distance. As an ECG signal, an electrocardiogram is obtained through the ECG signal, indicating the activity characteristics of the heart.
  • the wireless transmission unit uses Bluetooth communication to wirelessly transmit the resulting signal to the paired mobile terminal for recording and display.
  • the sleep state includes shallow sleep, deep sleep and waking; the coupled power is read out through the mutual power spectrum, and the sleep state is judged according to the frequency band in which the coupled power is located; the excessive power of the low frequency band is related to the periodic breathing of the sleep disordered breathing device, Excessive power in the high frequency band is associated with physiological sinus arrhythmia and deep sleep. If the coupled power is in the ultra-low frequency band, it is awake or deep sleep, and the ultra-low frequency band is 0.001 to 0.01 Hz; if the coupling power is in the low frequency band, it is light sleep, and the low frequency band is 0.01-0.1 Hz.
  • Another object of the present invention is to provide a cardiopulmonary coupled sleep quality detecting method based on an ultra-thin flexible strain and electrocardiographic sensor.
  • the strain sensor is attached to the surface of the chest, and the two ECG electrodes of the ECG sensor are respectively attached to the surface under the left chest; the strain sensor and the three resistance-changing resistors constitute the Wheatstone bridge, Wheatstone bridge
  • the two output terminals are electrically connected to the analog-to-digital conversion circuit;
  • the electrocardiographic sensor is electrically connected to the analog-to-digital conversion circuit;
  • the analog-to-digital conversion circuit, the amplification circuit, the filter circuit, and the microprocessor are sequentially electrically connected to form a signal acquisition and processing unit; signal acquisition processing
  • the unit and the wireless transmission unit are electrically connected and integrated on one circuit board; the mobile terminal is located outside the human body.
  • the cardiopulmonary coupled sleep quality detecting method based on the ultra-thin flexible strain and electrocardiographic sensor of the invention comprises the following steps:
  • an analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into a digital signal; the amplification circuit amplifies the signal;
  • the electrocardiogram signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit;
  • the microprocessor applies the cardiopulmonary coupling algorithm to calculate the cross-power spectrum and coherence of the ECG signal and the respiratory signal, reads the coupled power from the cross-power spectrum, determines the state of sleep, and judges the sleep state, and transmits the result wirelessly.
  • the unit transmits to the mobile terminal for recording and display.
  • the cardiopulmonary coupling algorithm calculates the cardiopulmonary coupling index, comprising the steps of: first identifying the QRS complex of the electrocardiogram, detecting the time and magnitude of the occurrence of the R peak, and processing the RR interval signal to obtain The normal heartbeat interval (NN interval), the re-sampling of the respiratory signal measured by the flexible strain sensor, adjusting the sampling frequency, calculating the NN interval and the mutual power spectrum and the coherence of the respiratory signal, thereby obtaining the cardiopulmonary Coupling (CPC) power spectrum.
  • N interval normal heartbeat interval
  • CPC cardiopulmonary Coupling
  • the sleep state is determined by the cardiopulmonary coupling index; the sleep state includes shallow sleep, deep sleep, and awake; the coupled power is read by the cross power spectrum, and the sleep state is determined according to the frequency band in which the coupled power is located; When the coupling power is in the ultra-low frequency band, it is awake or deep sleep, and the ultra-low frequency band is 0.001 to 0.01 Hz; if the coupling power is in the low frequency band, it is light sleep, and the low frequency band is 0.01 to 0.1 Hz.
  • the invention adopts an ultra-thin and flexible sensor, can be easily attached to the body surface of the sleeper, does not cause any discomfort or restraint feeling, and basically does not feel the presence of the sensor during the measurement, and minimizes the sleeper's
  • the effect truly reflects the state of the sleeper's sleep; the respiratory and electrocardiographic signals are measured by using an ultra-thin flexible sensor, and then the cardiopulmonary coupling algorithm is used to comprehensively analyze the respiratory and electrocardiographic signals to obtain the quantitative index parameters of the patient's sleep quality.
  • the signal is transmitted to the mobile terminal wirelessly, the overall system is small in size, and can be conveniently used in different sleeping occasions; the invention is simple and easy, the accuracy is high, and the use is convenient Comfortable.
  • FIG. 1 is a structural block diagram of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention
  • FIG. 2 is an exploded view of a strain sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention
  • FIG. 3 is a schematic diagram of an electrocardiographic sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and an electrocardiographic sensor according to the present invention
  • FIG. 4 is a top plan view of a device layer of a strain sensor of an cardiopulmonary coupled sleep quality detecting system based on an ultra-thin flexible strain and electrocardiographic sensor of the present invention
  • FIG. 5 is a schematic diagram of one embodiment of a cardiopulmonary coupled sleep quality detection system based on an ultra-thin flexible strain and electrocardiographic sensor applied to sleep detection according to the present invention.
  • the cardiopulmonary coupled sleep quality detecting system based on the ultra-thin flexible strain and electrocardiographic sensor of the embodiment includes: a strain sensor, an electrocardiographic sensor, an analog-to-digital conversion circuit, an amplifying circuit, a filtering circuit, and a microprocessor.
  • the strain sensor and the electrocardiographic sensor are ultra-thin flexible sensors, the strain sensor and three resistance-changing resistors form a Wheatstone bridge, and the two outputs of the Wheatstone bridge
  • the electrical connection is electrically connected to the analog-to-digital conversion circuit; the electrocardiographic sensor is electrically connected to the analog-to-digital conversion circuit; the analog-to-digital conversion circuit, the amplification circuit, the filter circuit and the microprocessor are electrically connected in sequence to form a signal acquisition and processing unit.
  • the strain sensor 1 includes an adhesive layer, a flexible substrate 11, a polymer protective layer 12, a device layer 13, and a package film 14; wherein a flexible substrate 11 is formed on the adhesive layer; and formed on the flexible substrate 11.
  • the electrocardiographic sensor 2 includes two electrocardiographic electrodes 21, a serpentine lead wire 22, and a connecting end 23; wherein, the two electrocardiographic electrodes 21 have a distance therebetween; and the two electrocardiographic electrodes respectively extend through the extensible
  • the serpentine lead wire 22 is connected to the connection end 23; the connection end is connected to the input end of the analog to digital conversion circuit; each electrocardiographic electrode adopts a grid structure, and the lines constituting the grid are curved serpentine lines.
  • the device layer 13 is a patterned metal film.
  • the strain sensor 1 when detecting the sleep quality of the patient, the strain sensor 1 is attached to the surface of the front chest, and the two electrocardiographic electrodes of the electrocardiographic sensor 2 are respectively attached to the surface 5 cm below the left breast left breast; signal acquisition Processing unit and wireless transmission unit Electrically connected and integrated on a circuit board 3; the mobile terminal 4 is located outside the human body.
  • the wireless transmission unit uses Bluetooth transmission.
  • an analog-to-digital conversion circuit converts the simulated respiratory signal and the electrocardiographic signal into a digital signal; the amplification circuit amplifies the signal;
  • the electrocardiogram signal is filtered to remove the noise signal and the high frequency signal; the microprocessor synthesizes the electrocardiogram signal into an electrocardiogram signal, and records the electrocardiogram signal; the respiratory signal and the electrocardiogram signal are transmitted to the mobile terminal through the wireless transmission unit;
  • the microprocessor applies the cardiopulmonary coupling algorithm to calculate the mutual power spectrum and coherence of the ECG signal and the respiratory signal, determines the sleep state, and transmits the result to the mobile terminal through the wireless transmission unit for recording and display.

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  • Engineering & Computer Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un système de détection de qualité de sommeil à couplage cardiopulmonaire à capteurs multiples et un procédé de détection associé. Un capteur de contrainte (1) flexible ultra-mince et un capteur d'ECG (2) sont fixés légèrement à la surface corporelle d'un dormeur sans provoquer d'inconfort ou de sensation de restriction quelconque, de sorte que la présence des capteurs ne puisse pas être ressentie pendant la mesure et l'impact sur le dormeur est réduit dans la plus grande mesure, reflétant ainsi véritablement l'état du dormeur lors du sommeil ; les capteurs flexibles ultra-minces sont utilisés pour mesurer des signaux de respiration et d'ECG et un algorithme de couplage cardiopulmonaire est utilisé pour analyser de manière complète les signaux de respiration et d'ECG afin d'obtenir des paramètres d'indice quantitatifs de la qualité de sommeil du patient et le nombre de caractéristiques apnéiques du syndrome d'apnée ; les signaux sont transmis à un terminal mobile à l'aide d'un procédé sans fil ; et le volume de l'ensemble du système est petit, ce qui facilite l'utilisation dans différents scénarios de sommeil, et est facile à utiliser, hautement précis, pratique à utiliser et confortable.
PCT/CN2017/115780 2017-01-16 2017-12-13 Système de détection de qualité de sommeil à couplage cardiopulmonaire à capteurs multiples et procédé de détection correspondant Ceased WO2018130036A1 (fr)

Applications Claiming Priority (2)

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CN201710028221.3A CN106859598A (zh) 2017-01-16 2017-01-16 一种多传感器心肺耦合睡眠质量检测系统及其检测方法
CN201710028221.3 2017-01-16

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CN114236287B (zh) * 2021-12-16 2023-12-08 国网上海市电力公司 基于多传感器的配电变压器检测系统及介质
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CN113974576B (zh) * 2021-12-23 2022-04-22 北京航空航天大学杭州创新研究院 一种基于心磁图的睡眠质量监测系统及监测方法
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