[go: up one dir, main page]

WO2018114456A1 - Device for extracorporeal blood gas exchange - Google Patents

Device for extracorporeal blood gas exchange Download PDF

Info

Publication number
WO2018114456A1
WO2018114456A1 PCT/EP2017/082344 EP2017082344W WO2018114456A1 WO 2018114456 A1 WO2018114456 A1 WO 2018114456A1 EP 2017082344 W EP2017082344 W EP 2017082344W WO 2018114456 A1 WO2018114456 A1 WO 2018114456A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood stream
measuring cuvette
gas
blood
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/082344
Other languages
German (de)
French (fr)
Inventor
Tilman Von Blumenthal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Draegerwerk AG and Co KGaA
Original Assignee
Draegerwerk AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draegerwerk AG and Co KGaA filed Critical Draegerwerk AG and Co KGaA
Priority to JP2019517243A priority Critical patent/JP6785954B2/en
Priority to US16/470,504 priority patent/US11547785B2/en
Priority to CN201780078719.9A priority patent/CN110072570B/en
Publication of WO2018114456A1 publication Critical patent/WO2018114456A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/3313—Optical measuring means used specific wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3

Definitions

  • Devices for extracorporeal blood gas exchange, in which a blood stream of a patient is guided in a blood flow area along a membrane.
  • the membrane forms a gas-liquid barrier towards a gas flow in a gas-conducting region.
  • the membrane allows a transition of carbon dioxide of the
  • Blood gas exchange is then returned to the patient via the same venous access.
  • a pump that may be present in the extracorporeal blood gas exchange device may affect a flow rate of blood flow along the membrane.
  • an oxygen source that oxygenates the gas flow may be controlled to influence how much oxygen transitions from the gas flow to the blood stream.
  • a depletion of carbon dioxide from the blood stream into a respiratory gas is usually carried out in the lungs to a degree so that the carbon dioxide content of the blood stream after passing the human lung still has a partial pressure of 40 mmHg when the patient is sufficiently healthy.
  • the partial pressure after passing through the human lung may still have a partial pressure of 60 mmHg.
  • Such a method of greatly depleting carbon dioxide from the bloodstream through an extracorporeal blood gas exchange device may be particularly advantageous when relatively low flow rates on the order of about 1 l / min of blood flow through the device are treated.
  • a disadvantage here may possibly be that excessive depletion of carbon dioxide from the bloodstream due to a non-ideal mixing of the treated blood stream with the untreated blood at the site of return to the patient's bloodstream, ie downstream of the re-feeding of the bloodstream, such locally Carbon dioxide partial pressures can be found which are below the usual carbon dioxide partial pressure of 40 mmHg. This may possibly lead to cell damage.
  • Particulate carbon dioxide pressure within the treated blood stream drops to a maximum of 20 mmHg or remains above this value.
  • optional sensors are provided for this purpose which can measure the respective partial pressure of carbon dioxide upstream or downstream of the membrane.
  • sensors which can measure the corresponding carbon dioxide partial pressure at a corresponding point within the bloodstream.
  • Blood circulation is basically a health risk or infection risk for the patient.
  • Object of the present invention is therefore to provide a device for
  • the object according to the invention is achieved by a device for extracorporeal blood gas exchange according to claim 1.
  • the device according to the invention for extracorporeal blood gas exchange has a blood flow region for guiding a blood flow, a gas-conducting region for guiding a gas flow, and a membrane which seals a gas flow.
  • Liquid barrier forms between the bloodstream and the gas flow and which further comprises a transition of carbon dioxide in the blood stream in the
  • the device has at least one measuring cuvette, which is at least partially delimited by the membrane from the blood stream region, so that carbon dioxide of the blood stream can pass into the measuring cuvette.
  • the device further comprises an optical measuring unit, which is designed to measure a carbon dioxide partial pressure located in the measuring cuvette.
  • This device is advantageous because the blood flow due to the separation of the cuvette from the blood flow through the membrane then just does not come into direct contact with the cuvette, but the cuvette is just from the point of view of the blood stream beyond the membrane and thus there in a special safe way an optical measuring unit can be used to measure the carbon dioxide partial pressure in the cuvette.
  • the invention makes use of the effect that the carbon dioxide partial pressure present in front of the membrane from the blood stream will also form after the membrane, ie in the measuring cuvette, after a sufficient period of time, so that it will then be drawn there by the measuring unit without a particular risk for the patient for an impurity of the bloodstream
  • Carbon dioxide partial pressure can be measured on the
  • the device is designed in such a way that the measuring cuvette is gastight by a cuvette wall in relation to the gas-conducting region
  • the device is designed such that the optical
  • Measuring unit is designed to emit optical radiation into the measuring cuvette and to detect a portion of the optical radiation transmitted through the measuring cuvette.
  • the device is designed such that the optical radiation is an infrared radiation.
  • the device is preferably designed in such a way that the measuring cuvette has a first optical window for the admission of the optical radiation into the measuring cuvette and a second optical window for the outlet of the optical radiation out of the cuvette.
  • the device is designed such that the device has an inflow side, at which the bloodstream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measurement cuvette is located at a position of the membrane corresponds to the inflow side.
  • the device is designed such that the device has an inflow side, at which the bloodstream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measurement cuvette is located at a position of the membrane corresponds to the downstream side.
  • the device is designed such that the membrane is given by a plurality of hollow fiber arrangements.
  • the device is designed such that the device has an inflow side, at which the blood stream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measuring cuvette is given by such a hollow fiber arrangement, which located near the inflow side.
  • the device is designed such that the device has an inflow side, at which the blood stream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measuring cuvette is given by such a hollow fiber arrangement, which located near the downstream side.
  • FIG. 1 shows a preferred embodiment of the invention
  • FIG. 2 a shows details of a preferred embodiment of a measuring cuvette
  • FIG. 2b shows a preferred embodiment of a measuring unit
  • FIG. 3 shows a further preferred embodiment of the invention
  • FIG. 1 shows the device V for extracorporeal blood gas exchange.
  • a bloodstream BS flows through an inflow region ES
  • the membrane M separates the blood stream area BB as a gas-liquid barrier toward a gas-carrying area GB, which leads to a gas flow GS. Through the membrane, a carbon dioxide content K can pass from the bloodstream BS in the gas flow and an oxygen content S of the
  • a measuring cuvette MK2 is delimited by the membrane M from the blood flow area BB.
  • carbon dioxide K can also pass from the bloodstream BS into the measuring cuvette MK2.
  • An optical measuring unit ME can in this case measure a carbon dioxide partial pressure located in the measuring cuvette MK2.
  • the measuring cuvette MK2 is closed gas-tight by a cuvette wall KW opposite the gas-conducting region GB.
  • the bloodstream BS flows into the device V on the inflow side ES, the bloodstream BS then flows out of the device V on the outflow side AS.
  • the measuring cuvette MK2 is located at such a point of the membrane M, which corresponds to the downstream side AS.
  • FIG. 2 a shows details of an embodiment of the measuring cuvette MK 1 as an embodiment MK 1 1. It should be noted that the measuring cuvette MK2 from FIG. 1 likewise operates in an analogous manner according to the one shown in FIG. 2a
  • Measuring cuvette MK1 1 may be formed.
  • the measuring cuvette MK1 1 in this embodiment has an optical window OF1, via which optical radiation can be introduced into the measuring cuvette.
  • the measuring cuvette MK1 1 has an optical window OF2, which is suitable for the outlet of an optical radiation from the measuring cuvette MK1 1 out.
  • FIG. 2b shows the measuring unit ME mentioned above with reference to FIG.
  • the measuring unit ME is designed to emit optical radiation OS into the measuring cuvette MK1 1 and to detect a part of the optical radiation OS transmitted through the measuring cuvette MK1 1.
  • the measuring unit ME has an optical emitter E, which is positioned correspondingly in front of the optical window OF1.
  • the measuring unit ME has one or more detectors D1, D2, by means of which corresponding wavelengths of the optical radiation OS transmitted through the measuring cuvette MK1 1 can be detected behind the optical window OF2.
  • the emitter E and the detectors D1, D2 are here in conjunction with a corresponding control or computing unit SE of the measuring unit ME.
  • a corresponding control or computing unit SE of the measuring unit ME Preferably, different wavelengths are detected by the detectors D1, D2.
  • Gas pressures or partial gas concentration based on at least two different optical wavelengths are known in the art, for example from German patent application with the application number 102015008323.6.
  • FIG. 3 shows a further preferred embodiment of a
  • Device V2 according to the invention for extracorporeal blood gas exchange.
  • the bloodstream BS flows in via an inflow side ES2 and flows out via an outflow side AS2.
  • the blood stream region BB2 is thereby separated from a gas-conducting region GB2, that the corresponding membrane M by several
  • Hollow fiber assemblies HA1, HA2 is given. Any such
  • Hollow fiber assemblies HA1, HA2 preferably has a plurality
  • hollow fiber arrangements HA1, HA2 can also be in the form of respective hollow fiber mats.
  • a hollow fiber mat is preferably an arrangement in which a hollow fiber arrangement according to the type
  • Hollow fiber array is arranged crossed on the type of hollow fiber assembly HA1. The same applies to a hollow fiber mat by forming several
  • Hollow fiber arrangement according to the type of hollow fiber arrangement HA2.
  • Such a hollow fiber mat then tensions a plane through which the bloodstream BS flows through the hollow fiber mat perpendicular to the plane.
  • the gas flow GS then flows through corresponding hollow fibers HF and it comes through the membrane material M through to the previously
  • hollow fibers HF of the outflow-side hollow fiber arrangement HA2 are brought together and bundled, so that in this way a region of a measuring cuvette MK1 1 is formed.
  • the corresponding hollow fibers HF of the outflow-side hollow fiber arrangements HA2 are preferably closed by a chamber wall KW2 at the fiber ends FE.
  • the measuring cuvette MK12 is provided by a hollow fiber arrangement HA2, which is located close to the inflow side.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A device for extracorporeal blood gas exchange is proposed. The device has a bloodstream region for guiding a bloodstream, a gas-guiding region for guiding a gas flow, a membrane which forms a gas-liquid barrier between the bloodstream and the gas flow and which moreover permits a transfer of carbon dioxide from the bloodstream into the gas flow, wherein the device moreover has at least one measurement cell which is at least partially delimited from the bloodstream region by the membrane, such that carbon dioxide of the bloodstream can transfer into the measurement cell, and wherein the device has an optical measuring unit which is configured to measure a carbon dioxide partial pressure present in the measurement cell.

Description

Vorrichtung zum extrakorporalen Blutgasaustausch  Device for extracorporeal blood gas exchange

Bekannt sind Vorrichtungen zum extrakorporalen Blutgasaustausch, bei welchen ein Blutstrom eines Patienten in einem Blutstrombereich entlang einer Membran geführt wird. Die Membran bildet eine Gas-Flüssigkeitsschranke hin zu einer Gasströmung in einem gasführenden Bereich. Devices are known for extracorporeal blood gas exchange, in which a blood stream of a patient is guided in a blood flow area along a membrane. The membrane forms a gas-liquid barrier towards a gas flow in a gas-conducting region.

Die Membran ermöglicht hierbei einen Übergang von Kohlendioxid des The membrane allows a transition of carbon dioxide of the

Blutstromes in die Gasströmung sowie einen Übergang von Sauerstoff der Gasströmung in den Blutstrom. Blood flow into the gas flow as well as a transition of oxygen of the gas flow into the bloodstream.

Hierdurch wird es ermöglicht, dass Kohlendioxid aus dem Blutstrom abgeführt wird und der Blutstrom ferner mit Sauerstoff angereichert wird. Der Blutstrom wird dann dem Patienten zugeführt. Die Entnahme des Blutstromes an dem Patienten kann hierbei über einen arteriellen Zugang erfolgen, wobei dann der Blutstrom nach Passieren der Vorrichtung dem Patienten wieder über einen venösen Zugang zurückgeführt wird. Dies ist eine sogenannte AV-ECMO This will allow carbon dioxide to be removed from the bloodstream and further enrich the bloodstream with oxygen. The bloodstream is then delivered to the patient. The removal of the blood stream to the patient can in this case take place via an arterial access, in which case the blood stream, after passing through the device, is returned to the patient again via a venous access. This is a so-called AV-ECMO

(extrakorporale Membran Oxygenierung). (extracorporeal membrane oxygenation).

Vorrichtungen zum extrakorporalen Blutgasaustausch werden häufig in Devices for extracorporeal blood gas exchange are often used in

Kombination einer Beatmung eines Patienten durch ein Beatmungsgerät verwendet. Combination of ventilation of a patient used by a ventilator.

Die Verwendung einer Vorrichtung zum extrakorporalen Blutgasaustausch ist insbesondere dann notwendig, wenn ein Patient aufgrund einer obstruktiven Lungenerkrankung, wie beispielsweise COPD, Kohlendioxid aus dem Blutstrom nicht in hinreichender Menge über die Lunge abatmen kann. Eine hohe The use of a device for extracorporeal blood gas exchange is particularly necessary when a patient due to obstructive pulmonary disease, such as COPD, carbon dioxide from the blood stream can not exhale in sufficient amount through the lungs. A high

Atemanstrengung birgt ein Risiko einer Fatigue der Atemmuskulatur, gleichzeitig führt ein erhöhter Kohlendioxidpartialdruck im Blut zu Stress und Übersäuerung. Anstelle einer sogenannten AV-ECMO ist es auch möglich, dass der Blutstrom dem Patienten über einen venovenösen Zugang entnommen wird und der Blutstrom nach Passieren der Vorrichtung zum extrakorporalen Breathing with breathing carries a risk of fatigue of the respiratory muscles, while an increased carbon dioxide partial pressure in the blood leads to stress and hyperacidity. Instead of a so-called AV-ECMO it is also possible that the blood stream is taken from the patient via a venovenous approach and the blood stream after passing through the device to the extracorporeal

Blutgasaustausch dann über denselben venovenösen Zugang dem Patienten wieder zugeführt wird. Blood gas exchange is then returned to the patient via the same venous access.

Eine möglicherweise in der Vorrichtung zum extrakorporalen Blutgasaustausch vorhandene Pumpe kann eine Strömungsgeschwindigkeit des Blutstromes entlang der Membran beeinflussen. Hierdurch kann das Maß, zu welchem pro Zeiteinheit Kohlendioxid aus dem Blutstrom in die Gasströmung abgeführt wird, beeinflusst werden. Ferner kann beispielsweise eine Sauerstoffquelle, welche die Gasströmung mit Sauerstoff anreichert, gesteuert werden, um einen Einfluss darauf zu nehmen, zu welchem Grad Sauerstoff von der Gasströmung in den Blutstrom übergeht. Ferner kann eine Gasfördereinheit vorhanden sein, welche eine Strömungsgeschwindigkeit der Gasströmung entlang der Membran beeinflussen, so dass ein Einfluss darauf genommen werden kann, wieviel Sauerstoff pro Zeiteinheit an der Membran für einen potentiellen Übergang von der Gasströmung in den Blutstrom bereitsteht. A pump that may be present in the extracorporeal blood gas exchange device may affect a flow rate of blood flow along the membrane. In this way, the extent to which carbon dioxide is removed from the bloodstream into the gas flow per unit time can be influenced. Further, for example, an oxygen source that oxygenates the gas flow may be controlled to influence how much oxygen transitions from the gas flow to the blood stream. Further, there may be a gas delivery unit which affects a flow rate of the gas flow along the membrane so that an influence can be made on how much oxygen per unit time is available at the membrane for a potential transition from the gas flow to the blood flow.

Eine Abreicherung von Kohlendioxid aus dem Blutstrom in ein Atemgas erfolgt in der Lunge üblicherweise zu einem Maß, sodass der Kohlendioxidanteil des Blutstromes nach Passieren der menschlichen Lunge noch einen Partialdruck von 40 mmHg aufweist, wenn der Patient hinreichend gesund ist. Leidet der Patient allerdings an einer obstruktiven Lungenkrankheit wie zum Beispiel COPD, so kann der Partialdruck nach Passieren der menschlichen Lunge noch einen Partialdruck von 60 mmHg aufweisen. A depletion of carbon dioxide from the blood stream into a respiratory gas is usually carried out in the lungs to a degree so that the carbon dioxide content of the blood stream after passing the human lung still has a partial pressure of 40 mmHg when the patient is sufficiently healthy. However, if the patient suffers from obstructive pulmonary disease such as COPD, the partial pressure after passing through the human lung may still have a partial pressure of 60 mmHg.

Aus der EP 2 777 801 A2 ist eine Anordnung bekannt, bei welcher durch eine Vorrichtung zum extrakorporalen Blutgasaustausch der Blutstrom deutlich stärker abgereichert wird, als dies in der menschlichen Lunge geschieht. Hierbei können möglicherweise Kohlendioxidpartialdrücke von 10-35 mmHg erreicht werden. Zum einen ermöglicht dies die Eliminierung eines großen Anteils von An arrangement is known from EP 2 777 801 A2, in which the blood stream is significantly depleted by a device for extracorporeal blood gas exchange, as happens in the human lung. It may be possible to reach carbon dioxide partial pressures of 10-35 mmHg. On the one hand, this makes it possible to eliminate a large proportion of

Kohlendioxid, als dies eigentlich in der menschlichen Lunge möglich ist. Solches stark abgereichertes Blut wird dann dem Patienten wieder über ein venovenosen Zugang zugeführt und mischt sich dort mit unbehandeltem Blut des Patienten in seinem Blutkreislauf, sodass sich nach dem Vermischen der jeweiligen Carbon dioxide than is actually possible in the human lung. Such heavily depleted blood is then returned to the patient via a venovenous approach, where it mixes with untreated blood of the patient in its circulatory system, so that after mixing the respective

Blutanteile wieder einen Kohlendioxidpartialdruck von ungefähr 40 mmHg bei einem hinreichend gesunden Patienten ergibt. Ein solches Verfahren mit einer starken Abreicherung von Kohlendioxid des Blutstromes durch eine Vorrichtung zum extrakorporalen Blutgasaustausch kann insbesondere dann vorteilhaft sein, wenn relativ geringe Flussmengen von der Größenordnung von ungefähr 1 l/min des Blutstromes durch die Vorrichtung behandelt werden. Again gives a partial carbon dioxide pressure of approximately 40 mmHg in a reasonably healthy patient. Such a method of greatly depleting carbon dioxide from the bloodstream through an extracorporeal blood gas exchange device may be particularly advantageous when relatively low flow rates on the order of about 1 l / min of blood flow through the device are treated.

Ein Nachteil kann hierbei möglicher weise darin bestehen, dass eine zu starke Abreicherung von Kohlendioxid aus dem Blutstrom aufgrund einer nicht idealen Vermischung des behandelten Blutstromes mit dem unbehandelten Blut am Ort der Rückführung in den Blutkreislauf des Patienten, also stromabwärts der Wiedereinspeisung des Blutstromes, lokal solche Kohlendioxidpartialdrücke ergeben kann, welche unterhalb des üblichen Kohlendioxidpartialdrucks von 40 mmHg liegen. Möglicherweise kann dies zu einer Zellschädigung führen. Zur Vermeidung dieses Risikos ist es prinzipiell wünschenswert, eine Messung des Kohlendioxidpartialdrucks in dem Blutstrom innerhalb der Vorrichtung zum extrakorporalen Blutgasaustausch messen zu können. Insbesondere ist dies stromabwärts, also nach Behandlung des Blutstromes durch die Vorrichtung zum extrakorporalen Blutgasaustausch, wünschenswert. Hierdurch könnte es vermieden werden, dass der Blutstrom nur in einem solchen Maß eine A disadvantage here may possibly be that excessive depletion of carbon dioxide from the bloodstream due to a non-ideal mixing of the treated blood stream with the untreated blood at the site of return to the patient's bloodstream, ie downstream of the re-feeding of the bloodstream, such locally Carbon dioxide partial pressures can be found which are below the usual carbon dioxide partial pressure of 40 mmHg. This may possibly lead to cell damage. To avoid this risk, it is in principle desirable to be able to measure a measurement of the carbon dioxide partial pressure in the bloodstream within the device for extracorporeal blood gas exchange. In particular, this is desirable downstream, ie after treatment of the blood stream by the device for extracorporeal blood gas exchange. In this way it could be avoided that the blood flow only to such an extent

Kohlendioxidabreicherung innerhalb der Vorrichtung erfährt, dass der Carbon dioxide depletion within the device learns that the

Kohlendioxidpartialdruck innerhalb des behandelten Blutstromes höchstens auf 20 mmHg sinkt bzw. oberhalb dieses Wertes bleibt. Aus der EP 2 777 801 A2 sind hierfür optional Sensoren vorgesehen, welche den jeweiligen Kohlendioxidpartialdruck stromauf- bzw. stromabwärts der Membran messen können. Particulate carbon dioxide pressure within the treated blood stream drops to a maximum of 20 mmHg or remains above this value. From EP 2 777 801 A2, optional sensors are provided for this purpose which can measure the respective partial pressure of carbon dioxide upstream or downstream of the membrane.

Prinzipiell sind im Bereich der ECMO-Technologie Sensoren bekannt, welche innerhalb des Blutstromes den entsprechenden Kohlendioxidpartialdruck an einer entsprechenden Stelle messen können. In principle, in the field of ECMO technology, sensors are known which can measure the corresponding carbon dioxide partial pressure at a corresponding point within the bloodstream.

Nachteilig ist es hierbei, dass eine Einbringung eines Sensors in den The disadvantage here is that a contribution of a sensor in the

Blutkreislauf grundsätzlich ein Gesundheitsrisiko bzw. Infektionsrisiko für die Patienten darstellt. Blood circulation is basically a health risk or infection risk for the patient.

Aufgabe der vorliegenden Erfindung ist es daher, eine Vorrichtung zum Object of the present invention is therefore to provide a device for

extrakorporalen Blutgasaustausch bereitzustellen, welche einen Sensor bzw. eine Messeinheit vorsieht, um auf für den Patienten sichere Weise darüber Aufschluss zu finden, welchen Wert der Kohlendioxidpartialdruck innerhalb des Blutstromes aufweist. To provide extracorporeal blood gas exchange, which provides a sensor or a measuring unit to find out in a safe way for the patient about what value of the carbon dioxide has partial pressure within the blood stream.

Hierbei soll es vermieden werden, zusätzliche Materialien in den Blutkreislauf einzubringen. Here it should be avoided to introduce additional materials in the bloodstream.

Die erfindungsgemäße Aufgabe wird gelöst durch eine Vorrichtung zum extrakorporalen Blutgasaustausch nach dem Anspruch 1 . The object according to the invention is achieved by a device for extracorporeal blood gas exchange according to claim 1.

Vorteilhafte Ausführungsformen der Erfindung sind Gegenstand der abhängigen Ansprüche und werden in der folgenden Beschreibung unter teilweiser Advantageous embodiments of the invention are the subject of the dependent claims and in the following description in part

Bezugnahme auf die Figuren näher erläutert. Referring to the figures explained in more detail.

Die erfindungsgemäße Vorrichtung zum extrakorporalen Blutgasaustausch weist einen Blutstrombereich zur Führung eines Blutstroms, einen gasführenden Bereich zur Führung einer Gasströmung, sowie eine Membran, welche eine Gas- Flüssigkeitsschranke zwischen dem Blutstrom und der Gasströmung bildet und welche ferner einen Übergang von Kohlendioxid des Blutstromes in die The device according to the invention for extracorporeal blood gas exchange has a blood flow region for guiding a blood flow, a gas-conducting region for guiding a gas flow, and a membrane which seals a gas flow. Liquid barrier forms between the bloodstream and the gas flow and which further comprises a transition of carbon dioxide in the blood stream in the

Gasströmung ermöglicht, auf. Ferner weist die Vorrichtung wenigstens eine Messküvette auf, welche zumindest teilweise durch die Membran von dem Blutstrombereich abgegrenzt wird, so dass Kohlendioxid des Blutstromes in die Messküvette übergehen kann. Die Vorrichtung weist ferner eine optische Messeinheit auf, welche ausgebildet ist, einen in der Messküvette befindlichen Kohlendioxidpartialdruck zu messen. Gas flow allows on. Furthermore, the device has at least one measuring cuvette, which is at least partially delimited by the membrane from the blood stream region, so that carbon dioxide of the blood stream can pass into the measuring cuvette. The device further comprises an optical measuring unit, which is designed to measure a carbon dioxide partial pressure located in the measuring cuvette.

Diese erfindungsgemäße Vorrichtung ist vorteilhaft, da der Blutstrom aufgrund der Trennung der Messküvette von dem Blutstrombereich durch die Membran dann eben nicht direkt mit der Messküvette in Kontakt kommt, sondern die Messküvette eben aus Sicht des Blutstromes jenseits der Membran liegt und somit dort auf besondere sichere Weise eine optische Messeinheit verwendet werden kann, um den in der Messküvette befindlichen Kohlendioxidpartialdruck messen zu können. This device according to the invention is advantageous because the blood flow due to the separation of the cuvette from the blood flow through the membrane then just does not come into direct contact with the cuvette, but the cuvette is just from the point of view of the blood stream beyond the membrane and thus there in a special safe way an optical measuring unit can be used to measure the carbon dioxide partial pressure in the cuvette.

Die Erfindung nutzt den Effekt aus, dass die aus Sicht des Blutstromes vor der Membran befindlichen Kohlendioxidpartialdruck sich auch hinter der Membran, also in der Messküvette, nach einem hinreichenden Zeitraum ausbilden wird, sodass dann dort durch die Messeinheit ohne ein besonderes Risiko für den Patienten bezogen auf eine Verunreinigung des Blutstromes ein The invention makes use of the effect that the carbon dioxide partial pressure present in front of the membrane from the blood stream will also form after the membrane, ie in the measuring cuvette, after a sufficient period of time, so that it will then be drawn there by the measuring unit without a particular risk for the patient for an impurity of the bloodstream

Kohlendioxidpartialdruck gemessen werden kann, um auf den Carbon dioxide partial pressure can be measured on the

Kohlendioxidpartialdruck in dem Blutstrom schließen zu können. To be able to conclude carbon dioxide partial pressure in the blood stream.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Messküvette durch eine Küvettenwand gegenüber dem gasführenden Bereich gasdicht Preferably, the device is designed in such a way that the measuring cuvette is gastight by a cuvette wall in relation to the gas-conducting region

abgeschlossen ist. is completed.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die optische Preferably, the device is designed such that the optical

Messeinheit ausgebildet ist, optische Strahlung in die Messküvette zu emittieren und einen durch die Messküvette transmittierten Anteil der optischen Strahlung zu detektieren. Measuring unit is designed to emit optical radiation into the measuring cuvette and to detect a portion of the optical radiation transmitted through the measuring cuvette.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die optische Strahlung eine Infrarotstrahlung ist. Preferably, the device is designed such that the optical radiation is an infrared radiation.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Messküvette ein erstes optisches Fenster zum Einlass der optischen Strahlung in die Messküvette hinein sowie ein zweites optische Fenster zum Auslass der optischen Strahlung aus der Messküvette heraus aufweist. The device is preferably designed in such a way that the measuring cuvette has a first optical window for the admission of the optical radiation into the measuring cuvette and a second optical window for the outlet of the optical radiation out of the cuvette.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Vorrichtung eine Einströmseite, an welcher der Blutstrom in die Vorrichtung einströmt, sowie eine Abströmseite, an welcher der Blutstrom aus der Vorrichtung abströmt, aufweist, und dass die Messküvette sich an einer Stelle der Membran befindet, welche zu der Einströmseite korrespondiert. Preferably, the device is designed such that the device has an inflow side, at which the bloodstream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measurement cuvette is located at a position of the membrane corresponds to the inflow side.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Vorrichtung eine Einströmseite, an welcher der Blutstrom in die Vorrichtung einströmt, sowie eine Abströmseite, an welcher der Blutstrom aus der Vorrichtung abströmt, aufweist, und dass die Messküvette sich an einer Stelle der Membran befindet, welche zu der Abströmseite korrespondiert. Preferably, the device is designed such that the device has an inflow side, at which the bloodstream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measurement cuvette is located at a position of the membrane corresponds to the downstream side.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Membran durch mehrere Hohlfaseranordnungen gegeben ist. Preferably, the device is designed such that the membrane is given by a plurality of hollow fiber arrangements.

Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Vorrichtung eine Einströmseite, an welcher der Blutstrom in die Vorrichtung einströmt, sowie eine Abströmseite, an welcher der Blutstrom aus der Vorrichtung abströmt, aufweist, und dass die Messküvette durch eine solche Hohlfaseranordnung gegeben ist, welche sich nahe der Einströmseite befindet. Vorzugsweise ist die Vorrichtung derart ausgebildet, dass die Vorrichtung eine Einströmseite, an welcher der Blutstrom in die Vorrichtung einströmt, sowie eine Abströmseite, an welcher der Blutstrom aus der Vorrichtung abströmt, aufweist, und dass die Messküvette durch eine solche Hohlfaseranordnung gegeben ist, welche sich nahe der Abströmseite befindet. Preferably, the device is designed such that the device has an inflow side, at which the blood stream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measuring cuvette is given by such a hollow fiber arrangement, which located near the inflow side. Preferably, the device is designed such that the device has an inflow side, at which the blood stream flows into the device, as well as an outflow side, at which the blood stream flows out of the device, and that the measuring cuvette is given by such a hollow fiber arrangement, which located near the downstream side.

Im Folgenden wird die Erfindung anhand spezieller Ausführungsformen ohne Beschränkung des allgemeinen Erfindungsgedankens anhand der Figuren näher erläutert. Dabei zeigen: In the following the invention with reference to specific embodiments without limiting the general inventive concept is explained in detail with reference to the figures. Showing:

Figur 1 eine bevorzugte Ausführungsform der erfindungsgemäßen FIG. 1 shows a preferred embodiment of the invention

Vorrichtung zum extrakorporalen Blutgasaustausch,  Device for extracorporeal blood gas exchange,

Figur 2a Details einer bevorzugten Ausführungsform einer Messküvette, FIG. 2 a shows details of a preferred embodiment of a measuring cuvette,

Figur 2b eine bevorzugte Ausführungsform einer Messeinheit, FIG. 2b shows a preferred embodiment of a measuring unit,

Figur 3 eine weitere bevorzugte Ausführungsform der erfindungsgemäßen FIG. 3 shows a further preferred embodiment of the invention

Vorrichtung zum extrakorporalen Blutgasaustausch.  Device for extracorporeal blood gas exchange.

Die Figur 1 zeigt die Vorrichtung V zum extrakorporalen Blutgasaustausch. FIG. 1 shows the device V for extracorporeal blood gas exchange.

Durch einen Einströmbereich ES strömt ein Blutstrom BS in einem A bloodstream BS flows through an inflow region ES

Blutstrombereich BB entlang Membran M und schließlich hin zu einem Bloodstream BB along membrane M and finally to a

Ausströmbereich AS. Outflow area AS.

Die Membran M trennt den Blutstrombereich BB als eine Gas- Flüssigkeitsschranke hin zu einem gasführenden Bereich GB, welcher eine Gasströmung GS führt. Durch die Membran hindurch kann ein Kohlendioxidanteil K von dem Blutstrom BS in die Gasströmung übergehen sowie ein Sauerstoffanteil S von der The membrane M separates the blood stream area BB as a gas-liquid barrier toward a gas-carrying area GB, which leads to a gas flow GS. Through the membrane, a carbon dioxide content K can pass from the bloodstream BS in the gas flow and an oxygen content S of the

Gasströmung GS in den Blutstrom BS. Gas flow GS into the bloodstream BS.

Eine Messküvette MK2 ist durch die Membran M von dem Blutstrombereich BB abgegrenzt. Hierbei kann Kohlendioxid K auch von dem Blutstrom BS in die Messküvette MK2 übergehen. A measuring cuvette MK2 is delimited by the membrane M from the blood flow area BB. In this case, carbon dioxide K can also pass from the bloodstream BS into the measuring cuvette MK2.

Eine optische Messeinheit ME kann hierbei einen in der Messküvette MK2 befindlichen Kohlendioxidpartialdruck messen. An optical measuring unit ME can in this case measure a carbon dioxide partial pressure located in the measuring cuvette MK2.

Die Messküvette MK2 ist durch eine Küvettenwand KW gegenüber dem gasführenden Bereich GB gasdicht abgeschlossen. The measuring cuvette MK2 is closed gas-tight by a cuvette wall KW opposite the gas-conducting region GB.

Während an der Einströmseite ES der Blutstrom BS in die Vorrichtung V einströmt, strömt dann der Blutstrom BS an der Abströmseite AS aus der Vorrichtung V ab. While the bloodstream BS flows into the device V on the inflow side ES, the bloodstream BS then flows out of the device V on the outflow side AS.

Die Messküvette MK2 befindet sich an einer solchen Stelle der Membran M, welche zu der Abströmseite AS korrespondiert. The measuring cuvette MK2 is located at such a point of the membrane M, which corresponds to the downstream side AS.

Hierdurch kann durch die Messeinheit ME an der Messküvette MK2 ein solcher Kohlendioxidanteil gemessen werden, welcher zu dem Kohlendioxidanteil des Blutstromes BS nach Abreicherung durch die Membran M korrespondiert. Es kann also dann hierdurch in vorteilhafter Weise ein Aufschluss darüber gefunden werden, welcher Kohlendioxidpartialdruck in dem Blutstrom BS herrscht, wenn der Blutstrom BS auf der Abströmseite AS die Vorrichtung V verlässt. In this way, by the measuring unit ME on the measuring cuvette MK2 such a carbon dioxide content can be measured, which corresponds to the carbon dioxide content of the blood stream BS after depletion by the membrane M. Thus, it can then be found in an advantageous manner by means of which carbon dioxide partial pressure prevails in the bloodstream BS, when the bloodstream BS leaves the device V on the downstream side AS.

Alternativ oder zusätzlich kann sich eine Messküvette MK1 , welche in analoger Weise zu der Messküvette MK2 ausgebildet ist und sich an einer solchen Stelle der Membran M befinden, welche zu der Einströmseite ES korrespondiert. Die Figur 2a zeigt Details einer Ausführung der Messküvette MK1 als eine Ausführungsform MK1 1 . Es ist anzumerken, dass die Messküvette MK2 aus der Figur 1 ebenso in analoger Weise gemäß der in der Figur 2a gezeigten Alternatively or additionally, a measuring cuvette MK1, which is designed in an analogous manner to the measuring cuvette MK2 and located at such a point of the membrane M, which corresponds to the inflow side ES. FIG. 2 a shows details of an embodiment of the measuring cuvette MK 1 as an embodiment MK 1 1. It should be noted that the measuring cuvette MK2 from FIG. 1 likewise operates in an analogous manner according to the one shown in FIG. 2a

Messküvette MK1 1 ausgebildet sein kann. Measuring cuvette MK1 1 may be formed.

Die Messküvette MK1 1 in dieser Ausführungsform weist ein optisches Fenster OF1 auf, über welches eine optische Strahlung in die Messküvette eingelassen werden kann. The measuring cuvette MK1 1 in this embodiment has an optical window OF1, via which optical radiation can be introduced into the measuring cuvette.

Ferner weist die Messküvette MK1 1 ein optisches Fenster OF2 auf, welches zum Auslass einer optischen Strahlung aus der Messküvette MK1 1 heraus geeignet ist. Furthermore, the measuring cuvette MK1 1 has an optical window OF2, which is suitable for the outlet of an optical radiation from the measuring cuvette MK1 1 out.

Figur 2b zeigt hierzu die Messeinheit ME, welche zuvor unter Bezug auf die Figur 1 erwähnt wurde. FIG. 2b shows the measuring unit ME mentioned above with reference to FIG.

Die Messeinheit ME ist ausgebildet, optische Strahlung OS in die Messküvette MK1 1 hinein zu emittieren und ein durch die Messküvette MK1 1 transmittierten Teil der optischen Strahlung OS zu detektieren. The measuring unit ME is designed to emit optical radiation OS into the measuring cuvette MK1 1 and to detect a part of the optical radiation OS transmitted through the measuring cuvette MK1 1.

Hierzu weist die Messeinheit ME einen optischen Emitter E auf, welcher entsprechend vor dem optischen Fenster OF1 positioniert ist. For this purpose, the measuring unit ME has an optical emitter E, which is positioned correspondingly in front of the optical window OF1.

Ferner weist die Messeinheit ME einen oder mehrere Detektoren D1 , D2 auf, durch welche entsprechende Wellenlängen der durch die Messküvette MK1 1 transmittierten optischen Strahlung OS hinter dem optischen Fenster OF2 detektiert werden können. Furthermore, the measuring unit ME has one or more detectors D1, D2, by means of which corresponding wavelengths of the optical radiation OS transmitted through the measuring cuvette MK1 1 can be detected behind the optical window OF2.

Der Emitter E und die Detektoren D1 , D2 sind hierbei in Verbindung mit einer entsprechenden Steuer- bzw. Recheneinheit SE der Messeinheit ME. Vorzugsweise werden durch die Detektoren D1 , D2 unterschiedliche Wellenlängen detektiert. Prinzipien der optischen Messung von partiellen The emitter E and the detectors D1, D2 are here in conjunction with a corresponding control or computing unit SE of the measuring unit ME. Preferably, different wavelengths are detected by the detectors D1, D2. Principles of optical measurement of partial

Gasdrücken bzw. partiellen Gaskonzentration auf Basis wenigstens zweier unterschiedlicher optischer Wellenlängen sind dem Fachmann bekannt, beispielsweise aus der deutschen Patentanmeldung mit der Anmeldenummer 102015008323.6. Gas pressures or partial gas concentration based on at least two different optical wavelengths are known in the art, for example from German patent application with the application number 102015008323.6.

Die Figur 3 zeigt eine weitere bevorzugte Ausführungsform einer FIG. 3 shows a further preferred embodiment of a

erfindungsgemäßen Vorrichtung V2 zum extrakorporalen Blutgasaustausch. Device V2 according to the invention for extracorporeal blood gas exchange.

Hierbei strömt der Blutstrom BS über eine Einströmseite ES2 ein und strömt über eine Abströmseite AS2 aus. In this case, the bloodstream BS flows in via an inflow side ES2 and flows out via an outflow side AS2.

Der Blutstrombereich BB2 wird hierbei dadurch von einem gasführenden Bereich GB2 getrennt, dass die entsprechende Membran M durch mehrere The blood stream region BB2 is thereby separated from a gas-conducting region GB2, that the corresponding membrane M by several

Hohlfaseranordnungen HA1 , HA2 gegeben ist. Jede solcher Hollow fiber assemblies HA1, HA2 is given. Any such

Hohlfaseranordnungen HA1 , HA2 weist vorzugsweise eine Mehrzahl an Hollow fiber assemblies HA1, HA2 preferably has a plurality

Hohlfasern HF auf. Hollow fibers HF on.

Solche Hohlfaseranordnungen HA1 , HA2 können auch in Form von jeweiligen Hohlfasermatten gegeben sein. Hierbei ist eine Hohlfasermatte vorzugsweise eine Anordnung, bei welcher eine Hohlfaseranordnung nach Art der Such hollow fiber arrangements HA1, HA2 can also be in the form of respective hollow fiber mats. Here, a hollow fiber mat is preferably an arrangement in which a hollow fiber arrangement according to the type

Hohlfaseranordnung HA1 senkrecht mit einer um 90 Grad rotierten Hollow fiber assembly HA1 perpendicular with a rotated 90 degrees

Hohlfaseranordnung nach Art der Hohlfaseranordnung HA1 gekreuzt angeordnet ist. Analoges gilt für eine Hohlfasermatte durch Ausbildung mehrerer Hollow fiber array is arranged crossed on the type of hollow fiber assembly HA1. The same applies to a hollow fiber mat by forming several

Hohlfaseranordnung nach Art der Hohlfaseranordnung HA2. Hollow fiber arrangement according to the type of hollow fiber arrangement HA2.

Eine solche Hohlfasermatte spannt dann eine Ebene auf, durch welche der Blutstrom BS senkrecht zur Ebene die Hohlfasermatte durchströmt. Die Gasströmung GS strömt dann durch entsprechende Hohlfasern HF und es kommt hierbei durch das Membranmaterial M hindurch zu dem zuvor Such a hollow fiber mat then tensions a plane through which the bloodstream BS flows through the hollow fiber mat perpendicular to the plane. The gas flow GS then flows through corresponding hollow fibers HF and it comes through the membrane material M through to the previously

beschriebenen Blutgasaustausch. described blood gas exchange.

Abströmseitig, also in der Nähe der Abströmseite AS2, sind Hohlfasern HF der abströmseitigen Hohlfaseranordnung HA2 zusammengeführt und gebündelt, so dass hierdurch ein Bereich einer Messküvette MK1 1 ausgebildet wird. Oberhalb der Abströmseite, also der Blutaustrittsöffnung, werden die entsprechenden Hohlfasern HF der abströmseitigen Hohlfaseranordnungen HA2 vorzugsweise durch eine Kammerwand KW2 an den Faserenden FE verschlossen. Hierdurch kann es erreicht werden, dass es durch noch nicht vollständig abgereicherte Blut im oberen Bereich des Blutstrombereiches BB2 zu einer Verfälschung des Messergebnisses kommt. On the outflow side, that is to say in the vicinity of the downstream side AS2, hollow fibers HF of the outflow-side hollow fiber arrangement HA2 are brought together and bundled, so that in this way a region of a measuring cuvette MK1 1 is formed. Above the outflow side, ie the blood outlet opening, the corresponding hollow fibers HF of the outflow-side hollow fiber arrangements HA2 are preferably closed by a chamber wall KW2 at the fiber ends FE. As a result, it can be achieved that blood is not completely depleted in the upper region of the blood flow region BB2 to falsify the measurement result.

An der Messküvette MK1 1 findet sich dann eine entsprechende Messeinheit ME, welche über entsprechende optische Fenster der Messküvette MK12 eine optische Messung nach dem Prinzip durchführt, welches zuvor unter Bezug die Figur 2b erläutert wurde. On the measuring cuvette MK1 1 there is then a corresponding measuring unit ME, which performs an optical measurement on the principle via corresponding optical windows of the measuring cuvette MK12, which was previously explained with reference to FIG. 2b.

Gemäß der Figur 3 ist die Messküvette MK12 durch eine Hohlfaseranordnungen HA2 gegeben, welche sich nahe der Einströmseite befindet. According to FIG. 3, the measuring cuvette MK12 is provided by a hollow fiber arrangement HA2, which is located close to the inflow side.

Es versteht sich für einen Fachmann, dass es ebenso möglich ist, eine It is obvious to a person skilled in the art that it is equally possible to have one

entsprechende Messküvette analog zu der Messküvette MK12 auszubilden, welche sich nahe der Einströmseite ES2 befindet. corresponding measuring cuvette analogous to the measuring cell MK12 form, which is located near the inflow side ES2.

Claims

Patentansprüche  claims 1 ) Vorrichtung (V, V2) zum extrakorporalen Blutgasaustausch, 1) device (V, V2) for extracorporeal blood gas exchange, aufweisend  including - einen Blutstrombereich (BB, BB2) zur Führung eines Blutstroms (BS), a blood flow area (BB, BB2) for guiding a blood flow (BS), - einen gasführenden Bereich (GB, GB2) zur Führung einer - A gas-conducting area (GB, GB2) to guide a Gasströmung (GS),  Gas flow (GS), - eine Membran (M), welche eine Gas-Flüssigkeitsschranke zwischen dem Blutstrom (BS) und der Gasströmung (GS) bildet und welche ferner einen Übergang von Kohlendioxid (K) des Blutstromes (BS) in die Gasströmung (GS) ermöglicht,  a membrane (M) which forms a gas-liquid barrier between the blood stream (BS) and the gas flow (GS) and which also allows a transition from carbon dioxide (K) of the blood stream (BS) into the gas flow (GS), dadurch gekennzeichnet, dass die Vorrichtung ferner wenigstens eine Messküvette (MK1 , MK2, MK1 1 ) aufweist, welche zumindest teilweise durch die Membran (M) von dem Blutstrombereich (BB, BB2) abgegrenzt wird, so dass Kohlendioxid (K) des Blutstromes (BS) in die Messküvette (MK1 , MK2, MK1 1 ) übergehen kann,  characterized in that the device further comprises at least one measuring cuvette (MK1, MK2, MK1 1) which is at least partially delimited by the membrane (M) from the blood flow region (BB, BB2), so that carbon dioxide (K) of the blood stream (BS ) can pass into the measuring cuvette (MK1, MK2, MK1 1), und dass die Vorrichtung (V, V2) eine optische Messeinheit (ME) aufweist, welche ausgebildet ist, einen in der Messküvette (MK1 , MK2, MK1 1 , MK12) befindlichen Kohlendioxidpartialdruck zu messen.  and that the device (V, V2) has an optical measuring unit (ME) which is designed to measure a carbon dioxide partial pressure located in the measuring cuvette (MK1, MK2, MK1 1, MK12). 2) Vorrichtung (V, V2) nach Anspruch 1 , 2) Device (V, V2) according to claim 1, dadurch gekennzeichnet, dass die Messküvette (MK1 , MK1 1 , MK2) durch eine Küvettenwand (KW, KW2) gegenüber dem gasführenden Bereich (GB) gasdicht abgeschlossen ist.  characterized in that the measuring cuvette (MK1, MK1 1, MK2) is closed gas-tight by a cuvette wall (KW, KW2) with respect to the gas-conducting region (GB). 3) Vorrichtung (V, V2) nach Anspruch 1 , 3) Device (V, V2) according to claim 1, dadurch gekennzeichnet, dass die optische Messeinheit (ME) ausgebildet ist, optische Strahlung (OS) in die Messküvette (MK1 , MK2, MK1 1 , MK12) zu emittieren und einen durch die Messküvette (MK1 , MK2, MK1 1 , MK12) transmittierten Anteil der optischen Strahlung (OS) zu detektieren. 4) Vorrichtung (V, V2) nach Anspruch 3, characterized in that the optical measuring unit (ME) is designed to emit optical radiation (OS) into the measuring cuvette (MK1, MK2, MK1 1, MK12) and a component transmitted through the measuring cuvette (MK1, MK2, MK1 1, MK12) the optical radiation (OS) to detect. 4) Device (V, V2) according to claim 3, dadurch gekennzeichnet, dass die optische Strahlung (OS) eine  characterized in that the optical radiation (OS) a Infrarotstrahlung ist.  Infrared radiation is. 5) Vorrichtung (V, V2) nach Anspruch 3, 5) Device (V, V2) according to claim 3, dadurch gekennzeichnet, dass die Messküvette (M1 , MK2, MK1 1 , MK12) characterized in that the measuring cuvette (M1, MK2, MK1 1, MK12) - ein erstes optisches Fenster (OF1 ) zum Einlass der optischen a first optical window (OF1) for the inlet of the optical Strahlung (OS) in die Messküvette (M1 , MK2, MK1 1 , MK12) hinein Radiation (OS) into the measuring cuvette (M1, MK2, MK1 1, MK12) - sowie ein zweites optische Fenster (OF2) zum Auslass der optischen Strahlung (OS) aus der Messküvette (MK1 , MK2, MK1 1 , MK12) heraus aufweist. - And a second optical window (OF2) to the outlet of the optical radiation (OS) from the measuring cuvette (MK1, MK2, MK1 1, MK12) has out. 6) Vorrichtung (V) nach Anspruch 1 , 6) Device (V) according to claim 1, dadurch gekennzeichnet, dass die Vorrichtung (V)  characterized in that the device (V) - eine Einströmseite (ES), an welcher der Blutstrom (BS) in die  - An inflow side (ES), at which the blood stream (BS) in the Vorrichtung (V) einströmt,  Device (V) flows in, - sowie eine Abströmseite (AS), an welcher der Blutstrom (BS) aus der Vorrichtung (V) abströmt,  and an outflow side (AS), at which the blood stream (BS) flows out of the device (V), aufweist,  having, und dass die Messküvette (MK1 , MK2, MK1 1 ) sich an einer Stelle der Membran (M) befindet, welche zu der Einströmseite (ES) korrespondiert.  and that the measuring cuvette (MK1, MK2, MK1 1) is located at a position of the membrane (M), which corresponds to the inflow side (ES). 7) Vorrichtung (V) nach Anspruch 1 , 7) Device (V) according to claim 1, dadurch gekennzeichnet, dass die Vorrichtung (V)  characterized in that the device (V) - eine Einströmseite (ES), an welcher der Blutstrom (BS) in die  - An inflow side (ES), at which the blood stream (BS) in the Vorrichtung (V) einströmt,  Device (V) flows in, - sowie eine Abströmseite (AS), an welcher der Blutstrom (BS) aus der Vorrichtung (V) abströmt,  and an outflow side (AS), at which the blood stream (BS) flows out of the device (V), aufweist,  having, und dass die Messküvette (MK1 , MK2, MK1 1 ) sich an einer Stelle der Membran (M) befindet, welche zu der Abströmseite (AS) korrespondiert. 8) Vorrichtung (V2) nach Anspruch 1 , and that the measuring cuvette (MK1, MK2, MK1 1) is located at a position of the membrane (M), which corresponds to the downstream side (AS). 8) Device (V2) according to claim 1, dadurch gekennzeichnet, dass die Membran (M) durch mehrere  characterized in that the membrane (M) by a plurality Hohlfaseranordnungen (HA1 , HA2) gegeben ist.  Hollow fiber arrangements (HA1, HA2) is given. 9) Vorrichtung (V2) nach Anspruch 8, 9) Device (V2) according to claim 8, dadurch gekennzeichnet, dass die Vorrichtung (V2)  characterized in that the device (V2) - eine Einströmseite (ES2), an welcher der Blutstrom (BS) in die  - An inflow side (ES2), at which the blood stream (BS) in the Vorrichtung (V) einströmt,  Device (V) flows in, - sowie eine Abströmseite (AS2), an welcher der Blutstrom (BS) aus der Vorrichtung (V2) abströmt,  and an outflow side (AS2), at which the blood stream (BS) flows out of the device (V2), aufweist,  having, und dass die Messküvette (MK12) durch eine solche Hohlfaseranordnung (HA2) gegeben ist, welche sich nahe der Einströmseite (ES2) befindet.  and that the measuring cuvette (MK12) is given by such a hollow fiber arrangement (HA2), which is located near the inflow side (ES2). 10) Vorrichtung (V2) nach Anspruch 8, 10) Device (V2) according to claim 8, dadurch gekennzeichnet, dass die Vorrichtung (V2)  characterized in that the device (V2) - eine Einströmseite (ES2), an welcher der Blutstrom (BS) in die  - An inflow side (ES2), at which the blood stream (BS) in the Vorrichtung (V) einströmt,  Device (V) flows in, - sowie eine Abströmseite (AS2), an welcher der Blutstrom (BS) aus der Vorrichtung (V) abströmt,  and an outflow side (AS2), at which the blood stream (BS) flows out of the device (V), aufweist,  having, und dass die Messküvette (MK12) durch eine solche Hohlfaseranordnung (HA2) gegeben ist, welche sich nahe der Abströmseite (AS2) befindet.  and that the measuring cuvette (MK12) is given by such a hollow fiber arrangement (HA2), which is located near the downstream side (AS2).
PCT/EP2017/082344 2016-12-19 2017-12-12 Device for extracorporeal blood gas exchange Ceased WO2018114456A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2019517243A JP6785954B2 (en) 2016-12-19 2017-12-12 Device for extracorporeal blood gas exchange
US16/470,504 US11547785B2 (en) 2016-12-19 2017-12-12 Extracorporeal blood gas exchange device
CN201780078719.9A CN110072570B (en) 2016-12-19 2017-12-12 Device for extracorporeal blood gas exchange

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016015059.9 2016-12-19
DE102016015059.9A DE102016015059B4 (en) 2016-12-19 2016-12-19 Device for extracorporeal blood gas exchange

Publications (1)

Publication Number Publication Date
WO2018114456A1 true WO2018114456A1 (en) 2018-06-28

Family

ID=60654982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/082344 Ceased WO2018114456A1 (en) 2016-12-19 2017-12-12 Device for extracorporeal blood gas exchange

Country Status (5)

Country Link
US (1) US11547785B2 (en)
JP (1) JP6785954B2 (en)
CN (1) CN110072570B (en)
DE (1) DE102016015059B4 (en)
WO (1) WO2018114456A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3781929T3 (en) * 2018-04-20 2022-09-12 Flo2R Aps Gas analyzer system
CN116036396A (en) * 2023-01-31 2023-05-02 北京航空航天大学 A membrane oxygenator

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080097233A1 (en) * 2004-04-20 2008-04-24 Rikshospitalet-Radiumhospitalet Hf Method and apparatus for estimating a paco2 value for a patient subject to extra corporeal circulation
US7687272B1 (en) * 1998-01-12 2010-03-30 Henry Buchwald Method and apparatus for determining blood oxygen transport
US20120148452A1 (en) * 2009-06-04 2012-06-14 Haemaflow Limited Non invasive gas analysis
EP2777801A2 (en) 2013-03-15 2014-09-17 Maquet Cardiopulmonary AG Device for eliminating CO2 from patient blood
EP2841126A1 (en) * 2012-04-27 2015-03-04 Estor SpA Process and apparatus for removing condensation from a device for the extracorporeal hematic treatment for the removal of carbon dioxide
EP2965770A1 (en) * 2014-07-09 2016-01-13 Universitätsklinikum Regensburg Blood oxygenator device
DE102015008323A1 (en) 2015-06-30 2017-01-05 Dräger Safety AG & Co. KGaA Method and device for determining a concentration of a gas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050056080A1 (en) * 2003-08-01 2005-03-17 Lucci Christopher Scott Blood monitoring system
GB2431470A (en) * 2005-10-21 2007-04-25 Autoliv Dev Assessing blood concentration of a volatile constituent
GB2437254B (en) * 2006-04-13 2010-11-17 Haemair Ltd Blood/air mass exchange apparatus
DE102006055157B3 (en) * 2006-11-22 2008-04-30 Siemens Ag Optical measuring cell for use in gas monitor, has light source for transferring light into measuring volume that is represented by inner volume of hollow fiber whose inner diameter is less than 1 millimeter
DE102011052187A1 (en) 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Arrangement for removing carbon dioxide from an extracorporeal blood stream by means of inert gases
DE102012110067A1 (en) * 2012-07-20 2014-05-15 Hypower Gmbh Method and apparatus for adjusting the amount or partial pressures of two gases in a fluid
EP3159026A1 (en) * 2015-10-23 2017-04-26 novalung GmbH Intermediate element for a medical extracorporeal fluid conduit, medical extracorporeal fluid system and method for measuring a gas contained in a fluid guided in a medical extracorporeal fluid system of the human or animal body

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687272B1 (en) * 1998-01-12 2010-03-30 Henry Buchwald Method and apparatus for determining blood oxygen transport
US20080097233A1 (en) * 2004-04-20 2008-04-24 Rikshospitalet-Radiumhospitalet Hf Method and apparatus for estimating a paco2 value for a patient subject to extra corporeal circulation
US20120148452A1 (en) * 2009-06-04 2012-06-14 Haemaflow Limited Non invasive gas analysis
EP2841126A1 (en) * 2012-04-27 2015-03-04 Estor SpA Process and apparatus for removing condensation from a device for the extracorporeal hematic treatment for the removal of carbon dioxide
EP2777801A2 (en) 2013-03-15 2014-09-17 Maquet Cardiopulmonary AG Device for eliminating CO2 from patient blood
EP2965770A1 (en) * 2014-07-09 2016-01-13 Universitätsklinikum Regensburg Blood oxygenator device
DE102015008323A1 (en) 2015-06-30 2017-01-05 Dräger Safety AG & Co. KGaA Method and device for determining a concentration of a gas

Also Published As

Publication number Publication date
JP2019528970A (en) 2019-10-17
US11547785B2 (en) 2023-01-10
DE102016015059A1 (en) 2018-06-21
CN110072570B (en) 2022-11-04
DE102016015059B4 (en) 2020-11-12
CN110072570A (en) 2019-07-30
US20190321534A1 (en) 2019-10-24
JP6785954B2 (en) 2020-11-18

Similar Documents

Publication Publication Date Title
DE3533557C2 (en) Measuring device for monitoring the CO¶2¶ content, the oxygen consumption and the respiratory quotient of a patient
DE69916907T2 (en) Oral / nasal cannula
EP0428927B1 (en) Process to determine hemodialysis parameters while treatment is in progress
EP1148907B1 (en) Non-invasive method for optimizing the respiration of atelectatic lungs
DE69229737T2 (en) Device for determining the condition of the lungs
DE69018271T2 (en) DEVICE FOR EXAMINING A PATIENT'S LUNG FUNCTION.
DE102008022761A1 (en) Apparatus for obtaining and analyzing respiratory gas samples
EP3352812B1 (en) Determination of gases dissolved in blood in the extracorporeal blood flow
DE102007038856A1 (en) Non-invasive determination of heart volume, gas exchange and gas concentration of the arterial blood
EP2927679A1 (en) Device for measuring and analysing the multiple breath nitrogen washout method
DE102014106489A1 (en) Device and device control method for the quantitative determination of the concentration of selected substances filtered out of a patient's body in a liquid
WO2008055478A1 (en) Measurement gas vessel for measurement of the concentration of gas components and method for production of a measurement gas vessel
WO2018114456A1 (en) Device for extracorporeal blood gas exchange
DE19962589A1 (en) Method and device for measuring a proportion of a measuring gas
DE102018003026A1 (en) Ventilation device with a safety valve
EP0742693A1 (en) Determination of the individual anaerobic threshold
EP3998941A1 (en) Method for determining the functional residual capacity of a patient's lung and ventilator for carrying out the method
DE60215955T2 (en) DEVICE FOR THE QUANTITATIVE ANALYSIS OF BREATHING GASES
EP4240516A1 (en) Method and device for separating carbon dioxide from a respiratory gas mixture
DE102010047546B4 (en) Method and device for automatic evaluation and analysis of a capnogram
DE102020117619A1 (en) Sensor arrangement, medical device, expiration valve and method for determining a carbon dioxide concentration in a measurement gas
EP3432962B1 (en) Assembly for measuring the flow rate of a patient during mechanical ventilation
DE102012220565A1 (en) Gas sampling line and gas analysis system
DE102021126681A1 (en) Method and device for monitoring blood purification with an extracorporeal blood purification device
EP4450104B1 (en) Determining a gas concentration in a breathing system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17811963

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2019517243

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17811963

Country of ref document: EP

Kind code of ref document: A1