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WO2018110903A3 - Classification method of molecular subtype of breast cancer and classification device of molecular subtype of breast cancer using same - Google Patents

Classification method of molecular subtype of breast cancer and classification device of molecular subtype of breast cancer using same Download PDF

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Publication number
WO2018110903A3
WO2018110903A3 PCT/KR2017/014345 KR2017014345W WO2018110903A3 WO 2018110903 A3 WO2018110903 A3 WO 2018110903A3 KR 2017014345 W KR2017014345 W KR 2017014345W WO 2018110903 A3 WO2018110903 A3 WO 2018110903A3
Authority
WO
WIPO (PCT)
Prior art keywords
breast cancer
molecular subtype
classification
same
differentially expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2017/014345
Other languages
French (fr)
Korean (ko)
Other versions
WO2018110903A2 (en
Inventor
김상우
백순명
서미경
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Yonsei University
Original Assignee
Industry Academic Cooperation Foundation of Yonsei University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Yonsei University filed Critical Industry Academic Cooperation Foundation of Yonsei University
Publication of WO2018110903A2 publication Critical patent/WO2018110903A2/en
Publication of WO2018110903A3 publication Critical patent/WO2018110903A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Evolutionary Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

The present invention provides a method for classifying molecular subtypes of breast cancer, the method comprising the steps of: acquiring expression levels of differentially expressed gene sets as measured in tumor cells; inputting the acquired expression levels of differentially expressed gene sets to a classification model having a parameter for the differentially expressed gene sets; determining a molecular subtype of breast cancer for tumor cells; and providing the determined molecular subtype of breast cancer.
PCT/KR2017/014345 2016-12-14 2017-12-08 Classification method of molecular subtype of breast cancer and classification device of molecular subtype of breast cancer using same Ceased WO2018110903A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0170132 2016-12-14
KR1020160170132A KR101874716B1 (en) 2016-12-14 2016-12-14 Methods for classifyng breast cancer subtypes and a device for classifyng breast cancer subtypes using the same

Publications (2)

Publication Number Publication Date
WO2018110903A2 WO2018110903A2 (en) 2018-06-21
WO2018110903A3 true WO2018110903A3 (en) 2018-08-09

Family

ID=62559072

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/014345 Ceased WO2018110903A2 (en) 2016-12-14 2017-12-08 Classification method of molecular subtype of breast cancer and classification device of molecular subtype of breast cancer using same

Country Status (2)

Country Link
KR (1) KR101874716B1 (en)
WO (1) WO2018110903A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7352937B2 (en) * 2019-07-19 2023-09-29 公立大学法人福島県立医科大学 Differential marker gene set, method and kit for differentiating or classifying breast cancer subtypes
KR102204958B1 (en) * 2019-10-28 2021-01-20 삼성에스디에스 주식회사 Processing method for result of medical examination
CN113278700B (en) * 2021-06-04 2022-08-09 浙江省肿瘤医院 Primer group and kit for breast cancer typing and prognosis prediction
WO2023034955A1 (en) * 2021-09-02 2023-03-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Machine learning-based systems and methods for predicting liver cancer recurrence in liver transplant patients
GB202116745D0 (en) * 2021-11-19 2022-01-05 Institute Of Cancer Res Royal Cancer Hospital Prognostic and treatment response predictive method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170351A1 (en) * 2002-02-20 2005-08-04 Patrick Tan Materials and methods relating to cancer diagnosis
WO2009158143A1 (en) * 2008-05-30 2009-12-30 The University Of North Carolina At Chapel Hill Gene expression profiles to predict breast cancer outcomes
US20140303133A1 (en) * 2011-11-18 2014-10-09 Vanderbilt University Markers of Triple-Negative Breast Cancer And Uses Thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170351A1 (en) * 2002-02-20 2005-08-04 Patrick Tan Materials and methods relating to cancer diagnosis
WO2009158143A1 (en) * 2008-05-30 2009-12-30 The University Of North Carolina At Chapel Hill Gene expression profiles to predict breast cancer outcomes
US20140303133A1 (en) * 2011-11-18 2014-10-09 Vanderbilt University Markers of Triple-Negative Breast Cancer And Uses Thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIST, M. O: "Classification of breast cancer subtypes by combining gene expression and DNA methylation data", JOURNAL OF INTEGRATIVE BIOINFORMATICS, vol. 11, no. 2, June 2014 (2014-06-01), pages 1 - 14, XP055531126 *
PARKER, J. S. ET AL.: "Supervised risk predictor of breast cancer based on intrinsic subtypes", JOURNAL OF CLINICAL ONCOLOGY, vol. 27, 10 March 2009 (2009-03-10), pages 1160 - 1167, XP009124878 *

Also Published As

Publication number Publication date
KR101874716B1 (en) 2018-07-04
KR20180068444A (en) 2018-06-22
WO2018110903A2 (en) 2018-06-21

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