WO2018105918A2 - Method for producing fibrous web, fibrillar fiber, or nonwoven fabric, and fibrous web, fibrillar fiber, or nonwoven fabric produced thereby - Google Patents

Abstract

The present invention relates to a method for producing fibrous webs, fibrillar fibers, or nonwoven fabrics, and fibrous webs, fibrillar fibers, or nonwoven fabrics produced thereby and, particularly, to fibrillar fibers or nonwoven fabrics for a hemostatic agent or an anti-adhesion agent.

Description

Process for producing fibrous web, fibrillated fibers or nonwovens and the fibrous web, fibrillated fibers or nonwovens produced thereby

The present invention relates to a process for producing fibrous webs, fibrillar fibers or nonwoven fabrics using woven fabrics, and the fibrous webs, fibrillated fibers or nonwovens, in particular so produced And fibrillated fibers or nonwovens for hemostatic or anti-adhesion use.

Nonwoven fabric refers to a textile product made by tangling various fibers according to mutual properties without going through a process such as twisting, weaving and knitting to form a sheet-like web and combining them by mechanical and physical methods.

Nonwoven fabric manufacturing process is generally composed of three steps, such as web formation → web bonding → processing. The web forming process is a process of dispersing and laminating fibers to a uniform thickness as possible on a conveyor to form a web. The web bonding process is a process of tangling or gluing the fiber aggregates to give the web a moderate strength so that the fibers do not separate to form stability. The processing process is a process of completing a nonwoven fabric by dyeing or processing required for the end use.

Nonwovens are classified into a wet method and a dry method according to the web formation method. Dry and wet are divided into whether the web is formed in a dry state or a wet state. That is, in the dry method, the fibers are formed in a web state in the air, and the wet method disperses the fibers in a liquid to obtain a web. Therefore, the web forming method is distinguished according to the matrix in which the fibers are dispersed, that is, air and liquid. On the other hand, the nonwoven fabric is divided into a long fiber nonwoven fabric and a short fiber nonwoven fabric according to the type of fiber.

Oxidized Regenerated Cellulose (ORC) is a known absorbent hemostatic substance. Many methods are known for forming various types of hemostatic agents based on Oxidized Cellulose (OC) into powders, fabrics, nonwovens, knitted fabrics, other forms and combinations thereof. Currently used hemostatic wound dressings include knitted or nonwoven fabrics comprising oxidized regenerated cellulose (ORC).

Korean Patent Laid-Open Publication No. 2013-0101109 discloses a step of providing a cellulose yarn having filaments of minimum twist; b) forming a multi-yarn, single feed circular knitted cellulose fabric with minimal twist; c) scouring the cellulose cloth; d) oxidizing the scoured fabric; e) pliabilizing the oxidized fabric; f) de-knitting the flexible fabric to form a continuous strand of crimp from about 2.0 crimps / cm (5 crimps / inch) to about 4.7 crimps / cm (12 crimps / inch). ; g) cutting the continuous strand to form staples that are about 3.8 to about 10.8 cm (about 1½ to about 4¼ inches) long; h) carding the staples into a carded batt; i) needle-punching the carded bat and entangling in three dimensions to form a single layer of nonwoven felt, the method of producing a resorbable hemostatic nonwoven dressing. However, the method includes the step of softening the oxidized fabric and then de-knitting it and cutting it to form a staple fiber of a certain length, which results in a long and complicated manufacturing process.

It is an object of the present invention to prepare a fibrous web, fibrillated fiber or nonwoven fabric which can simplify the process by directly applying a woven fabric other than short or long fibers to the carding process and the fibrous web and fibril thus produced. To provide a fibrillated fiber or nonwoven fabric usable for phase fibers or nonwovens, in particular for hemostatic or anti-adhesion applications.

According to one aspect of the invention, there is provided a method of making a fibrous web, comprising carding a woven fabric.

According to another aspect of the present invention, there is provided a method for producing fibrillated fibers, comprising calendering a fibrous web produced according to the above method.

According to another aspect of the present invention, there is provided a method of joining a fiber web prepared according to the above method; And calendering the bonded fibrous web.

According to another aspect of the present invention, there is provided a fibrous web, fibrillated fibers and a nonwoven fabric each produced by the above method.

According to the present invention, by applying the woven fabric, not short fibers or long fibers directly to the carding process, there is an advantage that can simplify the manufacturing process of the fibrous web, fibrillated fibers or nonwoven fabric.

Hereinafter, the present invention will be described in detail.

In the present invention, the term "fabric" is a concept including a knit.

In the present invention, the woven fabric used for the production of fibrous webs, fibrillated fibers or nonwovens is not short or long fibers.

In a preferred embodiment, the fabric may be Oxidized Regenerated Cellulose (ORC), Oxidized Cellulose (OC) or a combination thereof.

In the present invention, oxidized (regenerated) cellulose means oxidized (regenerated) cellulose having a carboxyl group (-COOH). The carboxyl group content (ie degree of oxidation) in the oxidized (regenerated) cellulose may be 13-24% by weight. According to one embodiment of the invention, the oxidized (regenerated) cellulose having an oxidation degree of 13 to 17% by weight is preferable in terms of enhancing the anti-adhesion effect, and the oxidation degree is more than 17% to 24% by weight, for example Oxidized (regenerated) cellulose, which is 18 to 24% by weight, is preferred in terms of enhancing the hemostatic effect.

Oxidized (regenerated) cellulose can be prepared according to methods known in the art, for example, US Pat. No. 7,279,177, US Pat. No. 3,364,200, US Pat. No. 5,180,398, US Pat. No. 5,134,229, US Pat. It may be prepared according to the method disclosed in US Pat. No. 7,645,874, US Pat. No. 5,914,003, and the like, but is not particularly limited thereto.

In a preferred embodiment, the tensile strength of the fabric is between 4 kgf and 25 kgf, more preferably between 6 kgf and 20 kgf. If the tensile strength of the fabric is lower than the above level can not be carded and powder shape, on the contrary, if higher than that can not be properly cut, there may be a problem that an unaligned part occurs when carding.

The method for producing a fibrous web according to the invention comprises carding a woven fabric.

In the carding step, the woven fabric is carded with a carded batt. In one embodiment of the carding process, the woven fabric is fed into a machine with rotating cylinders with fine metal teeth and "brushed" through the cylindrical teeth. The "brushed" web is then layered into bats on a take-up roller. The bat may be about 5-10 layers, especially about 7 layers, of the carded web.

In one embodiment, the density of the fibrous webs produced according to the invention is preferably 10 g / m ² to 60 g / m ² , more preferably 15 g / m ² to 30 g / m ² . If the density of the fibrous web is lower than the above level, there may be a problem in that the binding on the web is weak, so that it may not maintain a constant shape. On the contrary, the fiber web may be too bulky and may have a problem that web separation may occur when the web is laminated.

The method for producing fibrillated fibers according to the present invention includes calendering the manufactured fibrous web.

In one embodiment, the density of the fibrillary fibers produced according to the invention is preferably between 100 g / m ² and 600 g / m ² , more preferably between 150 g / m ² and 300 g / m ² . If the density of the fibrillated fibers is lower than the above level, the hemostatic effect may be low, and if the fibril-like fiber is high, the binding force may be reduced, and the web may be separated during hemostasis.

In a preferred embodiment, the fibrillated fibers are for use as hemostatic or anti-adhesion agents, in particular hemostatic agents.

The method for producing a nonwoven fabric according to the present invention comprises the steps of: bonding the prepared fibrous web; And calendaring the bonded fibrous web.

The bonding of the fibrous web may be a method known in the art, for example, a needle punching method, a thermal bonding method, a melt blow method, a spunlace method, a stitch bond method and the like, but is not particularly limited thereto. In a preferred embodiment, the fiber webs are joined by needle punching. In one embodiment, the carded bat is fed to a needle punching process in which a bed of baebed needles penetrates the bat when the bat passes through the machine. The barb-formed needles pull the bat fibers through each other, entangle the filaments in three dimensions and increase the structure density.

The bonded fibrous web is thus made into a nonwoven fabric through a calendering step as described above.

In one embodiment, the density of the nonwoven fabric produced according to the invention is preferably between 50 g / m ² and 600 g / m ² , more preferably between 80 g / m ² and 300 g / m ² . If the density of the nonwoven fabric is lower than the above level, the hemostatic effect may be low, and if high, the entanglement into the needle punching may be reduced, thereby reducing the binding force, thereby causing separation of the web during hemostasis.

In a preferred embodiment, the nonwoven is for use as a hemostatic or anti-adhesion agent, in particular a hemostatic agent.

The present invention will be described in more detail with reference to the following examples, which are only intended to illustrate the present invention, and the scope of the present invention is not limited in any way by the examples.

EXAMPLE

Example 1

Woven regenerated cellulose (Regenerated Cellulose) with a tensile strength of 10 kgf was oxidized with nitrogen dioxide (oxidation degree: 19%) and dried.

Thereafter, woven oxidized regenerated cellulose (ORC) was properly arranged through a carding process under the conditions shown in Table 1 below to prepare a sheet-shaped web, and the density of the single-ply web obtained was about 15 g / m ² . Was measured.

TABLE 1

Subsequently, fibrillated fibers were formed through a calendering process under the conditions shown in Table 2 below.

TABLE 2

Example  2

Woven oxidized regenerated cellulose (ORC) obtained in Example 1 was properly arranged through a carding process under the following conditions to prepare a sheet-shaped web, and then bonded through needle punching under the conditions shown in Table 3 below. .

TABLE 3

Subsequently, a nonwoven fabric having a predetermined thickness was formed through a calendering process under the conditions shown in Table 2 above.

The density of the obtained nonwoven fabric was measured to be about 85 g / m ² .

Example  3

In order to evaluate the hemostatic effect of the fibrillated fibers obtained in Example 1, a model small animal test in which the kidneys of rats were excised was performed. As a result, the mean blood loss value lost until hemostasis is shown in Table 4 below.

In Table 4, part of rat kidneys were excised and left alone to control natural hemostasis, and sample 1 was attached to fibril-like fibers after ablation.

TABLE 4

As can be seen from the results in Table 4, the fibrillary fibers according to the present invention show excellent hemostatic effect.

Example 4

In order to evaluate the hemostatic effect of the nonwoven fabric obtained in Example 2, a model small animal test in which the kidney of the rat was excised was performed. As a result, mean blood loss values lost until hemostasis are shown in Table 5 below.

In Table 5, part of rat kidneys were excised and left alone to hemostatically control, and sample 2 was attached to non-woven fabric after hemolysis.

TABLE 5

As can be seen from the results in Table 5, the nonwoven fabric according to the present invention shows excellent hemostatic effect.

Claims (11)

Carding a woven fabric. The method of claim 1, wherein the fabric is oxidized regenerated cellulose, oxidized cellulose, or a combination thereof. The method of claim 1 wherein the tensile strength of the fabric is between 4 kgf and 25 kgf. A method for producing fibrillated fibers, comprising calendering a fibrous web made according to the method of claim 1. Joining the fibrous webs prepared according to the method of any one of claims 1 to 3; And calendering the bonded fibrous web. The method of claim 5, wherein the fiber web is joined by needle punching. A fibrous web prepared according to the method of any one of claims 1 to 3, having a density of 10 g / m ² to 60 g / m ² . Fibrillated fibers prepared according to the method of claim 4, having a density of 10 g / m ² to 60 g / m ² . The fibril-like fiber of claim 8 for use as a hemostatic or anti-adhesion agent. A nonwoven fabric prepared according to the method of claim 5 and having a density of 50 g / m ² to 600 g / m ² . The nonwoven fabric of claim 10 for use as a hemostatic or anti-adhesion agent.