WO2018105755A1 - Cosmetics containing nanoparticles having encapsulated therein whitening-improving active ingredient, and method for producing said cosmetics - Google Patents

Abstract

The present invention relates to cosmetics for improving whitening of the skin, more specifically to cosmetics containing nanoparticles for which solubility in water has been increased by forming micelles of hydrophobic whitening-improving active ingredient. Furthermore, the cosmetics according to the present invention can provide the benefit of enhancing penetration of the whitening-improving active ingredient into the skin by means of the nanoparticles having encapsulated therein the whitening-improving active ingredient having excellent long-term stability and skin penetration.

Description

Cosmetics containing nanoparticles containing whitening improvement active substance and preparation method thereof

The present invention relates to a cosmetic for improving skin whitening, and more particularly, to a field of cosmetics including nanoparticles that have increased solubility in water by micellizing a hydrophobic whitening improving substance.

Glabridine, a substance that is effective in whitening and improvement in the present invention, is a fat-soluble antioxidant obtained from licorice, and shows excellent efficacy in inhibiting oxidation, inflammation, and aging of low-density lipoproteins that are harmful to the human body. It has an excellent effect on the anti-tyrosinase activity compared to other whitening ingredients known to this effect, there is an increasing number of examples of producing a functional cosmetic with a whitening effect using it. However, glabridine or whitening improvers extracted from licorice are hydrophobic and have low solubility in water, making them difficult to apply to functional cosmetics having a whitening effect.

In order to solve these problems, glabridine and various whitening improvers are used in the biocompatible biodegradable polymer PEG-PCL-PEG triblock copolymer (Patent Document 1) or PEG-PCL-PEG triblock copolymer. Efforts have been made to further include phospholipids (Patent Document 2), but the long-term stability of the biodegradable polymer PEG-PCL-PEG triblock copolymer used is poor and the composition prepared therefrom contains solvents and additives, The disadvantage is that it takes a long time to solubilize.

In addition, Patent Document 3 forms a complex of Gemini-type surfactant, higher alcohol, co-emulsifier, ceramide, cholesterol, etc., having two hydrophilic groups and two hydrophobic groups in one molecule, which are completely different from those of the conventional surfactant. The present invention discloses a cosmetic composition in which oil-soluble licorice extract is stabilized in the interfacial multiliquid crystal, but the interfacial multiliquid crystal has a problem of poor skin penetration effect due to a large problem of particle size of about 1.0 to 3.0 μm in the shape of four petals. .

Furthermore, Patent Document 4 discloses nanoparticles in which at least one hydrophobic active ingredient is stabilized using a biodegradable polymer, but does not contain an antioxidant, so that the hydrophobic active ingredient may be oxidized and discolored over time. This is large, there is a problem in that the stability of the particles and the efficiency of skin absorption enhancement of the active ingredient is inferior.

Thus, the present inventors can prepare a whitening improvement active material such as licorice extract glabridine without a solvent or other additives in a simple way, and increase the solubility in water, even after a long time, whitening improvement nanoparticles excellent skin penetration While making efforts to make the composition, the whitening improvement nanoparticle composition of the present invention was confirmed to maintain a stable particle shape even after a long time, solubility and easy skin permeation completed the present invention.

The present invention has been made in order to improve the problems according to the prior art of cosmetics, an object of the present invention is to provide a cosmetic containing nanoparticles are sealed whitening improvement material excellent in long-term stability and skin penetration.

The present invention is to realize the desired object as described above,

1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)]; And a skin permeation promoter 0.5 to 30 parts by weight;

1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; And stirring the mixture to which 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] is added (step 1); And a skin permeation promoter 0.5 to 30 parts by weight to the mixture; adding and dispersing (step 2).

Cosmetics according to the present invention presented as described above can obtain the effect of improving the skin permeability of the whitening improvement active material through the nanoparticles containing the whitening improvement active material excellent in long-term stability and skin penetration.

1 is a view showing a whitening improvement nanoparticles of cosmetics containing a nanoparticles containing the whitening improvement active material according to the present invention.

Figure 2 is a photograph of diluting the whitening improvement nanoparticles of Example 1 in water.

Figure 3 is a photograph of diluting the whitening improvement nanoparticles of Example 2 in water.

Figure 4 is a photograph of diluting the whitening improvement nanoparticles of Example 3 in water.

5 is a photograph of diluting the whitening improvement nanoparticles of Example 4 in water.

6 is a photograph of the discolored whitening improvement nanoparticles of Example 4 after one month.

7 is a photograph of the discolored whitening improvement nanoparticles of Example 5 after one month.

8 is a graph showing the size of the gloridine particle of Example 2 over time.

9 is a graph showing the particle size distribution of Example 1 measured.

10 is a graph showing the particle size distribution of Example 2 measured.

11 is a graph showing the particle size distribution of Example 3 measured.

12 is a graph showing the particle size distribution of Example 4 measured.

13 is a graph showing the particle size distribution of Example 5 measured.

14 is an experimental photograph of Experimental Example 2.

Hereinafter, described in detail with reference to the accompanying drawings of the present invention.

Cosmetics Containing Nanoparticles Encapsulated with Whitening Improvement

The present invention is 1 part by weight of whitening improvement active material;

1 to 30 parts by weight of a glycol solvent;

1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)]; And

It provides a cosmetic comprising a nanoparticles containing a whitening improvement active material, including; 0.5 to 30 parts by weight of a skin permeation accelerator. At this time, the nanoparticles preferably have a particle size of 20 to 150 nm.

Here, the whitening improvement active material is glabridin, Boswellin CG, Alma extract, Alpha lipoate, Sabi white, Sim white 377), rucinol, curcuminoids and the like can be used, with the use of glabridine or shim white. At this time, the curcuminoid is preferably curcumin.

In addition, the glycol solubilizers serve to dissolve the whitening improvement active material to micellize.

In this case, the glycol dissolving agent may be ethylene glycol, propylene glycol, tetraethylene glycol, polyethylene glycol, polypropylene glycol, polybutylene glycol, and the like, preferably a compound represented by the following formula (1).

[Formula 1]

In Chemical Formula 1,

R ₁ is hydrogen or methyl;

R ₂ is hydrogen or an ester group; And

a is an integer of 1 to 200.

In this case, the glycol dissolving agent may be used 1 to 30 parts by weight, preferably 5 to 20 parts by weight, most preferably 10 parts by weight based on 1 part by weight of the whitening improvement active substance. If the glycol-based solubilizer is contained in an amount of less than 1 part by weight based on 1 part by weight of the whitening-improving active substance, the dispersion of the whitening-improving active substance is incomplete, which makes it difficult to release the whitening-improving active substance in future use. If it exceeds 30 parts by weight with respect to 1 part by weight of the effective active material, there is a problem that the stability of the whitening improvement active material is insufficient and the reagent is wasted.

Furthermore, in order to further improve the solubility of the whitening improvement active substance by the glycols solubilizer, glycofurol, polysorbate, cremophore, solutol HS (Solutol HS 15) and the like may be further mixed and used.

In addition, the triblock copolymers in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] play a role of micelle formation and have poloxamer 184, poloxamer 185, poloxamer 188, and polox. Sammer 124, Poloxamer 237, Poloxamer 338, Poloxamer 407 and the like can be used.

Preferably the triblock copolymers are compounds represented by the following formula (2).

[Formula 2]

In Chemical Formula 2,

b, c and d are independently integers from 1 to 200.

Herein, the triblock copolymers are preferably contained in an amount of 1 to 30 parts by weight, more preferably 5 to 20 parts by weight, and most preferably 10 parts by weight, based on 1 part by weight of the whitening improvement active substance. If the triblock copolymers are contained in an amount of less than 1 part by weight based on 1 part by weight of the whitening improvement active substance, there is a problem that precipitation of the whitening improvement active substance occurs, and 30 parts by weight of 1 part by weight of the whitening improvement active substance. In the case of exceeding a part, there is a problem that the particle size is increased and stability is lowered.

Furthermore, the skin permeation accelerator is diethylene glycol monoethyl ether, isopropyl myristate, isostearyl glyceryl ether, polysorbate 80, Sorbitan sesquioleate, Caprylocaproyl macrogolglycerides, Oleoyl macrogolglycerides, Sodium lauryl sulfate, Hexadecyltrimethyl ammonium bromide Hexadecyltrimethylammonium bromide, Cetrimide, Benzethonium chloride, Cetylpyridinium chloride, Polyoxyl-10-stearylether (Brij 56), Polyoxyl-20-cetylether (Brij 58), polyoxyl-2-stearyl ether (Brij 72), polyoxyl-10-stearyl ether (Brij 76), polyoxyl-2-olee Ether (Brij 93), polyoxyl-10-oleyl ether (Brij 97), polyoxyl-35-caster oil (Cremophor EL), polyoxyl-40-hydrogenate (Cremophor RH40), polyoxyl-60-hydro Zenate (Cremophor RH60) etc. can be used.

Here, the skin permeation promoter is preferably contained in 0.5 to 30 parts by weight based on 1 part by weight of the whitening improvement active substance. If the skin permeation accelerator is contained in an amount of less than 0.5 parts by weight based on 1 part by weight of the whitening improvement active substance, there is a problem that skin permeability is not secured, and 30 parts by weight based on 1 part by weight of the whitening improvement active substance. If it exceeds, there is a problem in that excess amount of the skin permeation accelerator required for skin permeation is contained and the reagent is wasted.

The nanoparticles containing the whitening improvement active material effectively prevent oxidation over time of the whitening improvement active material to increase the efficacy of the whitening improvement active material and to increase the stability of the nanoparticles by 0.1 to 1 parts by weight. Α-lipoic acid, α-Tocopherol, α-Tocopherol, Retinol, Glutathione, Butylated hydroxy toluene, Genistein, Quercetin, Propyl gallate, Epigallocatechin gallate, Gallocatechin gallate, Silybin, Diosmetin, Kaempferol , Epicatechin, galangin, and the like can be used.

If the antioxidant is contained in an amount of less than 0.1 part by weight based on 1 part by weight of the whitening improvement active material, there is a problem that does not prevent the oxidation of the whitening improvement active material. In this case, there is a problem that the reagent is wasted because an excess amount of the antioxidant is required to prevent oxidation of the whitening improvement active substance.

[Cosmetic Manufacturing Method Including Nanoparticles Encapsulated with Whitening Improvement Material]

In addition, the present invention is a step of adding and stirring a glycol dissolving agent and a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] to the whitening improvement active material (step 1) ; And

It provides a cosmetic manufacturing method comprising the nanoparticles containing the whitening improvement active material comprising the step of adding and dispersing the skin permeation promoter (step 2).

The manufacturing method according to the present invention can produce a cosmetic including nanoparticles having a particle size of 20 to 150 nm in which the whitening improvement active material is encapsulated. At this time, the nanoparticles produced by the manufacturing method, improve the solubility of the cosmetic containing the nanoparticles and excellent long-term stability, it is useful as a manufacturing method that can improve the applicability of the whitening improvement active material as a whitening improvement cosmetics Can be used.

Hereinafter, a detailed description will be given step by step of a cosmetic manufacturing method comprising a nanoparticle encapsulated whitening improvement active material according to the present invention.

In the method for preparing a nanoparticle containing a whitening improving active material according to the present invention, step 1 is a glycol dissolving agent and a [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO) )] Is a step of adding and stirring the triblock copolymers in the form.

At this time, the stirring temperature may be 20 to 100 ℃, 40 to 80 ℃ is preferred.

In the method for preparing nanoparticles containing the whitening improvement active material according to the present invention, step 2 is a step of dispersing by adding a skin permeation promoter.

At this time, the step of performing the step 1 before the step 2 may be further performed by adding an antioxidant.

Hereinafter, the present invention will be described in detail by Examples and Experimental Examples.

However, the following Examples and Experimental Examples are only illustrative of the present invention, and the content of the present invention is not limited by Examples and Experimental Examples.

Preparation Example 1 Preparation of Glabridin

Glavdine was prepared by purchasing a product developed by Intubio as a licorice-derived oil-soluble ingredient.

<Manufacture example 2> Preparation of the seam white (symwhite 377)

Sim white 377 (Phenylethyl Resorcinol) was prepared and purchased from Symrise, Germany.

Example 1 Preparation of Cosmetics Containing Liquid Glybridine Nanoparticles

After adding polyethylene glycol (PEG400) (100 mg) to 10 mg of glabridine, poloxamer 188 (F-68, 100 mg), which is a triblock copolymer, was added and melted at 60 ° C. to include cosmetic liquid granules containing nanoparticles. Was prepared (FIG. 2).

<Example 2> Preparation of cosmetic containing the easy liquid article L 'Abri Dean nanoparticles on skin penetration

100 mg of the skin permeation accelerator (Brij 58) was further added to the liquid glabridine nanoparticles prepared in Example 1 to prepare for easy skin permeation (FIG. 3).

Example 3 Preparation of Cosmetics Containing Liquid Shim White Nanoparticles

Polyethylene glycol (PEG400) (100 mg) was added to 10 mg of shim white, followed by addition of poloxamer 188 (F-68, 100 mg), a triblock copolymer, and melted at 60 ° C. to prepare a cosmetic containing liquid shim white nanoparticles. (FIG. 4).

<Example 4> Preparation of cosmetic containing a liquid core easily isolated nanoparticles on skin penetration

100 mg of a skin permeation accelerator (Brij 58) was added to the liquid shim white nanoparticles prepared in Example 3, and thus prepared for easy skin permeation (FIG. 5).

<Example 5> Preparation of a cosmetics including nanoparticles whitening improvement for preventing oxidation of whitening improvement ingredient

Polyethylene glycol (PEG400) (100 mg) and α-tocopherol (5 mg), antioxidants, were added to Shim White, and poloxamer 188 (F-68, 100 mg), a triblock copolymer, was melted at 60 ° C and then dissolved in liquid nano. Particles were prepared, and 100 mg of skin permeation accelerator (Brij 58) was added to the prepared whitening nanoparticle composition to prepare a cosmetic including whitening nanoparticles that are stable to oxidation reaction and promote skin permeation.

Experimental Example 1 Long-term Stability Evaluation

In order to evaluate the long-term stability of the cosmetic containing the whitening improvement nanoparticles according to the present invention, the following experiment was performed.

The whitening improvement nanoparticles of Examples 1 to 5 prepared above were observed with the naked eye over time after preparation, and the results are shown in Table 1, and the result was visually observed after one month to observe the discoloration over time. 6 and 7 show the results, and the particle size of the gloridine of Example 2 over time was measured and shown in FIG. 8.

Example 1 Example 2 Example 3 Example 4 Example 5 Sedimentation O X O X X

Table 1 is a table showing the precipitation of Examples 1 to 5.

6 is a photograph of the discolored whitening improvement nanoparticles of Example 4 after one month.

7 is a photograph of the discolored whitening improvement nanoparticles of Example 5 after one month.

8 is a graph showing the particle size of the glabridine over time according to the present invention.

Referring to FIGS. 6 and 7, in Example 4, after one month, the whitening improvement compound was oxidized and discolored. However, in Example 5, discoloration does not occur even after one month, and thus whitening improvement nanoparticles are stable to the oxidation reaction. .

Referring to Figure 8, the glabridine of the whitening improved nanoparticles according to the present invention can be seen that the long-term stability is excellent as it maintains the particle size even after 6 months.

Therefore, the whitening improvement nanoparticles according to the present invention have excellent solubility including skin permeation accelerator, and further include an antioxidant to prevent oxidation of the whitening improvement substance, thereby improving long-term stability, and its particle size even after a long time Since it can be maintained, it can be usefully used as a cosmetic for improving whitening by containing it as an active ingredient.

Experimental Example 2 Measurement of Whitening Improvement Nanoparticle Size

The particle size of Examples 1 to 5 was measured to evaluate whether the cosmetic including the whitening-improving nanoparticles according to the present invention has a size suitable for skin permeation.

The measured results of the whitening improvement nanoparticles are shown in Table 2, 9, 10, 11, 12 and 13.

Example One 2 3 4 5 Particle size (nm) 240.5 38.9 190.4 30.4 43.2

Looking at Table 2, it was confirmed that the whitening-improving nanoparticles of Examples 2, 4 and 5 to which the skin permeation accelerator was added are smaller in particle size than the whitening-improving nanoparticles of Examples 1 and 3 that do not contain the skin permeation promoter. Can be.

Therefore, by including a skin permeation accelerator, a cosmetic including the whitening-improving nanoparticles of the present invention can easily obtain the effect of permeating the skin.

Experimental Example 3 Evaluation of Whitening Effect

In order to evaluate the whitening effect of the whitening improvement compound of the present invention, the following experiment was carried out.

Modification of the method of measuring dopa chrome produced by the action of tyrosinase by colorimetric method, inhibiting tyrosinase activity of shim white, which is a glabridine or another kind of whitening functional compound used in the embodiment of the present invention Was measured.

Specifically, 40 μl of 1.5mM L-Tyrosine solution and 10 μl of glabridine or shim white were added to a 96-well plate of 110 μl of 0.1 M Phosphate buffer (pH 6.5). 10 μl of mushroom tyrosinase (2000 unit / ml) was added and reacted at 37 ° C. for 10 minutes to measure dopachrome at 490 nm using a microplate counter. Arbutin was used as the substance, and the experimental results are shown in Table 3.

sample Arbutin Glabridin Seam white (Symwhite377) density One% 2% 5% 0.001% 0.005% 0.01% 0.05% 0.1% 0.5% Inhibitory effect 56.1% 68.7% 72.2% 83.3% 88.1% 89% 90.5% 91.3% 91.5%

Table 3 shows that arbutin exhibits a tyrosinase inhibitory effect of 50 to 70% even when tested with a relatively high concentration of solution, whereas glabridine and seam white nanoparticles, which are easy to penetrate the skin even with a relatively low concentration of solution, It was found that the tyrosinase was suppressed by an effect of 80% or more, which shows that the melanogenesis was excellently suppressed.

Therefore, the whitening improvement active substance of the present invention is excellent in whitening improvement by inhibiting melanin formation, and cosmetics containing the whitening improvement nanoparticles of the present invention containing the same as an active ingredient can obtain the effect of whitening improvement.

As can be seen through Experimental Example 1 to Experimental Example 3, the cosmetics containing the whitening improvement nanoparticles according to the present invention has a small particle size (20 to 150nm) is excellent in solubility and skin permeability, effectively oxidizing the whitening improvement compound Because it prevents the long-term stability is excellent, it can be usefully used as a whitening improvement cosmetics containing it as an active ingredient.

In addition, the cosmetic containing the nanoparticles containing the whitening improvement active material of the above configuration can be configured to be mixed in the cosmetic composition according to a known technique, each composition ratio can be appropriately configured according to the judgment of those skilled in the art.

In addition, the cosmetics according to the present invention can be used as an active ingredient of cosmetics that can be classified into a kind such as skin, toner, essence, emulsion, lotion, cream, face mist, cleansing or face pack emulsion. That is, the kind of cosmetics can be divided according to the dosage form as an active ingredient according to the present invention and may further comprise a variety of carrier components for forming each formulation.

Preferably, when the cosmetic according to the present invention is an active ingredient, and the formulation of the cosmetic to be prepared is a paste, cream or gel, the carrier component is animal fiber, plant fiber, wax, paraffin, starch, trakant, cellulose derivative. , Polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used.

In addition, when the cosmetic according to the present invention as an active ingredient, and the formulation of the cosmetic to be prepared is a powder or a spray, the carrier component is any one or more of lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder May be used, and in particular when the formulation is a spray, it may further comprise a propellant of any one or more of chloro fluorohydrocarbon, propane / butane or dimethyl ether.

In addition, the cosmetic according to the present invention as an active ingredient, in the case of the formulation of the cosmetic to be prepared is a solution or emulsion, the carrier component may be used as a solvent, solvating agent or emulsifying agent. More specifically, the carrier component may be selected from fatty acid esters of water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan. It can be any one or more.

In addition, when the cosmetic preparation according to the invention as an active ingredient, and the formulation of the cosmetic preparation is a suspension, the carrier component is a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester And suspending agents such as polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum meta hydroxide, bentonite, agar or tracant.

In addition, when the cosmetic according to the present invention as an active ingredient, and the formulation of the cosmetic is prepared with a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, already Dazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters The above can be used.

In connection with the above, the carrier of this kind may be mixed with cosmetics according to the present invention (which serves as an active ingredient of the cosmetics to be manufactured) in various composition ratios, and the preferred composition ratios thereof are known according to the use of the cosmetics produced. The technique can be applied as appropriate.

The above has been described with reference to a preferred embodiment of the present invention, but is not limited to the above embodiment, the person having ordinary skill in the art to which the present invention pertains through the above embodiments without departing from the gist of the present invention Can be implemented in a variety of changes.

Claims (9)

1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)]; And 0.5 to 30 parts by weight of a skin permeation accelerator; a cosmetic comprising nanoparticles encapsulated with a whitening improvement active material, comprising: a. The method of claim 1, The whitening improvement active substance is glabridin, Boswellin CG, Alma extract, Alpha lipoate, Sabi white, Sim white 377, Cosmetics comprising nanoparticles encapsulated with a whitening improvement active material, characterized in that at least one selected from the group consisting of rucinol and curcuminoid. The method of claim 1, The glycol solubilizer includes nanoparticles containing whitening improvement active material, characterized in that at least one selected from the group consisting of ethylene glycol, propylene glycol, tetraethylene glycol, polyethylene glycol, polypropylene glycol, and polybutylene glycol. Cosmetics. The method of claim 1, The triblock copolymers in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] are poloxamer 184, poloxamer 185, poloxamer 188, poloxamer 124, poloxamer 237, poloxamer Cosmetics comprising nanoparticles encapsulated with a whitening improvement active substance, characterized in that at least one selected from the group consisting of 338 and poloxamer 407. The method of claim 1, The skin permeation promoter is diethylene glycol monoethyl ether, isopropyl myristate, isostearyl glyceryl ether, polysorbate 80, sorbitan Sorbitan sesquioleate, Caprylocaproyl macrogolglycerides, Oleoyl macrogolglycerides, Sodium lauryl sulfate, Hexadecyltrimethylammonium bromide Hexadecyltrimethylammonium bromide ), Cetrimide, Benzethonium chloride, Cetylpyridinium chloride, Polyoxyl-10-stearyl ether (Brij 56), Polyoxyl-20-cetyl ether (Brij 58) , Polyoxyl-2-stearyl ether (Brij 72), polyoxyl-10-stearyl ether (Brij 76), polyoxyl-2-oleyl ether ( Brij 93), polyoxyl-10-oleylether (Brij 97), polyoxyl-35-caster oil (Cremophor EL), polyoxyl-40-hydrogenate (Cremophor RH40) and polyoxyl-60-hydrogenate (Cremophor RH60) A cosmetic comprising a nanoparticle encapsulated with a whitening improvement active substance, characterized in that at least one selected from the group consisting of. The method of claim 1, The nanoparticles in which the whitening improvement active material is encapsulated may include 0.1 to 1 parts by weight of an antioxidant based on 1 part by weight of the whitening improvement active material. . The method of claim 6, The antioxidant is α-lipoic acid (α-lipoic acid), α-Tocopherol (α-Tocopherol), Retinol, Glutathione, Butylated hydroxy toluene, Genistein, Quercetin (Quercetin, Propyl gallate, Epigallocatechin gallate, Gallocatechin gallate, Silybin, Diosmetin, Kaempferol, Epicatechin (Epicatechin) and cosmetics comprising a nanoparticles encapsulated whitening improvement active material, characterized in that at least one member selected from the group consisting of Galangin (Galangin). 1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; And stirring the mixture to which 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] is added (step 1); And 0.5 to 30 parts by weight of a skin permeation promoter to the mixture; adding and dispersing (step 2); cosmetic production method comprising a nanoparticles encapsulated whitening improvement active material comprising a. The method of claim 8, Prior to performing step 2, the method of manufacturing a cosmetic comprising nanoparticles containing a whitening improvement active material further comprising the step of adding an antioxidant to the mixture.

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