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WO2018105438A1 - Filière - Google Patents

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Publication number
WO2018105438A1
WO2018105438A1 PCT/JP2017/042544 JP2017042544W WO2018105438A1 WO 2018105438 A1 WO2018105438 A1 WO 2018105438A1 JP 2017042544 W JP2017042544 W JP 2017042544W WO 2018105438 A1 WO2018105438 A1 WO 2018105438A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube wall
spinning nozzle
hollow needle
fine fiber
tip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2017/042544
Other languages
English (en)
Japanese (ja)
Inventor
紀之 河原
遠藤　喜重
宗男 水本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stem Cell & Device Laboratory Inc
Original Assignee
Stem Cell & Device Laboratory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stem Cell & Device Laboratory Inc filed Critical Stem Cell & Device Laboratory Inc
Priority to JP2018554931A priority Critical patent/JP6944198B2/ja
Publication of WO2018105438A1 publication Critical patent/WO2018105438A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D4/00—Spinnerette packs; Cleaning thereof
    • D01D4/02—Spinnerettes
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/04—Dry spinning methods

Definitions

  • the present invention relates to a spinning nozzle used in an electrospinning apparatus at the time of producing a fine fiber sheet, a method for producing the same, and a method for producing a fine fiber sheet.
  • a microfiber is a fiber having a micro-order diameter
  • a nanofiber is a fiber having a nano-order diameter.
  • an electrospinning method electrospinning method
  • a high voltage is applied between the spinning nozzle and the collector, and a solution as a raw material of the fine fiber is jetted from the spinning nozzle toward the collector by the Coulomb force, and the fine fiber is accumulated in a sheet form on the collector surface. It is a method.
  • the fine fiber sheet produced in this way includes a non-woven fabric formed by randomly intertwining fine fibers and a type in which fine fibers are aligned in a specific direction.
  • Patent Document 1 discloses an electrospinning apparatus suitable for manufacturing the latter sheet, that is, a highly oriented fine fiber sheet.
  • a Taylor cone is formed by a solution as a raw material for fine fiber, just below the tip opening (spinning port) of the spinning nozzle.
  • the Taylor cone forms a generally inverted cone shape as shown in FIG. 1A.
  • a filamentous solution called a spinning jet protrudes from the tip of the Taylor cone and is pulled toward the collector.
  • FIG. 1A shows the form of a Taylor cone and a spinning jet, which are ideal for producing a highly oriented fine fiber sheet. That is, in order to produce a highly oriented fine fiber sheet, it is desirable that the Taylor cone be formed in a shape that is substantially rotationally symmetric with respect to the center axis of the spinning nozzle. It may be desirable to extend straight toward the collector. On the other hand, in the conventional electrospinning apparatus, for example, as shown in FIG. 1B, the shape of the Taylor cone is often distorted or the direction of the spinning jet is shifted. In addition, as shown in FIG. 1C, a plurality of spinning jets may be formed from one spinning nozzle.
  • the object of the present invention is to stably produce a fine fiber sheet.
  • the spinning nozzle according to the first aspect of the present invention is a spinning nozzle used in an electrospinning apparatus when manufacturing a fine fiber sheet, and includes a hollow needle.
  • the hollow needle has a tube wall that defines a spinning port through which a solution that is a raw material of the fine fiber is injected.
  • the thickness of the tube wall at the tip of the hollow needle is 35 ⁇ m or less.
  • the spinning nozzle according to the second aspect of the present invention is the spinning nozzle according to the first aspect, and the thickness of the tube wall at the tip of the hollow needle is 30 ⁇ m or less.
  • the spinning nozzle according to the third aspect of the present invention is the spinning nozzle according to the second aspect, and the thickness of the tube wall at the tip of the hollow needle is 15 ⁇ m or less.
  • the spinning nozzle according to the fourth aspect of the present invention is the spinning nozzle according to the third aspect, and the thickness of the tube wall at the tip of the hollow needle is 10 ⁇ m or less.
  • the spinning nozzle according to the fifth aspect of the present invention is the spinning nozzle according to any one of the first to fourth aspects, and the outer surface of the tube wall is a metal surface.
  • a spinning nozzle according to a sixth aspect of the present invention is the spinning nozzle according to any one of the first to fifth aspects, wherein a tip surface of the tube wall perpendicular to the central axis direction of the tube wall is non-polished. Surface.
  • a spinning nozzle according to a seventh aspect of the present invention is the spinning nozzle according to any one of the first to sixth aspects, wherein the distal end portion of the tube wall is substantially rotationally symmetric with respect to a central axis of the tube wall. It has a tapered surface of various shapes.
  • the spinning nozzle according to the eighth aspect of the present invention is a spinning nozzle according to any one of the first to seventh aspects, and is a disposable nozzle that is detachable from the main body of the electrospinning apparatus.
  • a spinning nozzle manufacturing method is a spinning nozzle manufacturing method used in an electrospinning apparatus at the time of manufacturing a fine fiber sheet, and includes the following (1) and (2).
  • (1) Prepare a hollow needle.
  • (2) Using a cutting tool whose blade edge forms an inclined surface, the tip of the tube wall of the hollow needle is formed with a tapered surface having a shape that is substantially rotationally symmetric with respect to the central axis of the tube wall. So as to cut.
  • (2) includes the following (2-1) and (2-2).
  • (2-1) The cutting edge of the tube wall is moved so that the cutting edge reaches the position of the inner peripheral surface of the tube wall along the radial direction of the tube wall or a position inside the inner peripheral surface. Move and position relative to the tip.
  • the manufacturing method of the fine fiber sheet which concerns on the 10th viewpoint of this invention contains the following (1) and (2).
  • An electrospinning apparatus comprising a hollow needle having a tube wall defining a spinneret, a collector, and a power source for applying a voltage between the hollow needle and the collector. Preparing an electrospinning apparatus in which the thickness of the tube wall at the tip is 35 ⁇ m or less; (2) Using the electrospinning apparatus, spraying a solution as a raw material of fine fiber from the spinning port toward the collector to form the fine fiber sheet on the collector surface.
  • the method for producing a fine fiber sheet according to the eleventh aspect of the present invention is the method for producing according to the tenth aspect, wherein the fine fiber sheet is an oriented fine fiber sheet.
  • the thickness of the tube wall at the tip of the hollow needle of the spinning nozzle is 35 ⁇ m or less. According to the verification by the present inventors, this configuration can stabilize the form of the Taylor cone and the spinning jet. Therefore, a fine fiber sheet can be manufactured stably.
  • FIG. 1 is a schematic front view of an electrospinning apparatus according to an embodiment of the present invention.
  • the functional block diagram of the electrospinning apparatus of FIG. The side view of the spinning nozzle which concerns on one Embodiment of this invention.
  • FIG. 5 is a side sectional view in which a tip portion of the spinning nozzle of FIG. 4 is enlarged.
  • 1 is a schematic plan view of a cutting apparatus for manufacturing a spinning nozzle according to an embodiment of the present invention. The figure which shows a mode when a blade edge
  • FIG. 2 is a schematic front view of an electrospinning apparatus 1 according to an embodiment of the present invention
  • FIG. 3 is a functional block diagram thereof.
  • the electrospinning apparatus 1 is an apparatus for producing fine fibers using an electrospinning method (electrospinning method) as an operating principle.
  • the fine fiber here is a fiber having a micro-order or nano-order diameter.
  • the electrospinning apparatus 1 includes a housing 2, and includes a spinning nozzle 10, a collector 20, and a power supply 30 in the housing 2.
  • the power source 30 is a power source for applying a high voltage between the spinning nozzle 10 and the collector 20.
  • An openable / closable door 2a is installed in front of the housing 2, and the fine fiber manufacturing space S1 in the housing 2 can be accessed by opening the door 2a.
  • the door 2a is formed at least partially transparent, and in this case, the manufacturing process of the fine fiber can be observed. That is, the state of the Taylor cone and the spinning jet can be confirmed during the production of the fine fiber, and any abnormality can be dealt with immediately.
  • a syringe 3 for containing a solution L ⁇ b> 1 as a raw material for fine fiber is accommodated.
  • the solution L1 that is a raw material of the fine fiber is typically a solution in which a polymer that is a raw material of the fiber is dissolved in a volatile solvent.
  • the syringe 3 is driven by a drive mechanism 4 that is also housed in the housing 2, whereby the solution L ⁇ b> 1 in the syringe 3 is sent to the spinning nozzle 10 via the tube 7.
  • the drive mechanism 4 can be configured as appropriate.
  • the drive mechanism 4 can be configured from a motor that reciprocates the plunger of the syringe 3 with respect to the cylinder.
  • the spinning nozzle 10 is also driven by a driving mechanism 6 accommodated in the housing 2 as shown in FIG. Thereby, the spinning nozzle 10 can reciprocate in the left-right direction.
  • the left and right here are defined based on the state of FIG.
  • the drive mechanism 6 can be configured as appropriate.
  • the drive mechanism 6 can be configured from a slider that supports the spinning nozzle 10, a slide rail that slides the slider, a motor that moves the slider along the slide rail, and the like.
  • the tube 7 mentioned above is comprised from a flexible material so that the influence of such a movement of the spinning nozzle 10 can be absorbed.
  • the spinning nozzle 10 stands up and down, and is fixed to the drive mechanism 6 in such a posture that the spinning port 10a at the tip thereof faces downward.
  • the collector 20 is arrange
  • the collector 20 receives the solution L1 ejected from the spinneret 10a by the Coulomb force on the surface thereof.
  • the collector 20 of this embodiment is a rotary drum type, and is driven by a drive mechanism 5 that is also housed in the housing 2 as shown in FIG.
  • the collector 20 is a cylindrical body and is supported in a posture such that the central axis extends in the left-right direction, and rotates around the central axis when driven by the drive mechanism 5.
  • the drive mechanism 5 can be configured as appropriate.
  • the drive mechanism 5 can be configured from a shaft that passes through the central axis of the collector 20 and a motor that rotates the shaft.
  • An operation unit 8 including operation buttons and a display is installed beside the door 2a in front of the housing 2.
  • the user can start and forcibly stop the spinning operation by operating the operation unit 8, and the horizontal moving speed and moving width of the spinning nozzle 10 during the spinning operation, the rotational speed of the collector 20, and the solution
  • Various control parameters such as the flow rate of L1 can be set.
  • the electrospinning apparatus 1 has a control unit 9 that controls the operation of the electrospinning apparatus 1.
  • the control unit 9 includes a CPU, a ROM, a RAM, a non-volatile storage device, and the like.
  • the CPU reads and executes a program stored in the ROM or the storage device, thereby performing various operations including a spinning operation. Realize.
  • the control unit 9 is connected to the drive mechanisms 4 to 6, the operation unit 8, and the power supply 30, and causes them to execute the operations described above and later.
  • FIG. 4 is a side view of the spinning nozzle alone.
  • the spinning nozzle 10 includes a hollow needle 12 and a base portion 11 that is firmly fixed to the upper end of the hollow needle 12.
  • the hollow needle 12 is made of metal and serves as an electrode for forming an electric field between the spinning nozzle 10 and the collector 20.
  • the other electrode is a collector 20.
  • the spinning nozzle 10 is a disposable nozzle that can be attached to and detached from the main body of the electrospinning apparatus 1.
  • the base portion 11 serves as a connector for connecting the hollow needle 12 to the main body of the electrospinning apparatus 1.
  • the internal space of the hollow needle 12 communicates with the tube 7. Therefore, at this time, the solution L1 sent out from the syringe 3 reaches the inner space of the hollow needle 12, passes through here, and reaches the spinning port 10a at the tip. At this time, a Taylor cone is formed below the spinneret 10a due to the surface tension of the solution L1.
  • the hollow needle 12 has a tube wall 121.
  • the spinneret 10a through which the solution L1 is injected is defined by the tube wall 121.
  • the tube wall 121 is a substantially cylindrical body having a central axis A1 extending linearly.
  • FIG. 5 is an enlarged side sectional view of the tip of the hollow needle 12 of FIG.
  • the distal end portion of the tube wall 121 forms a tapered surface 122
  • the tapered surface 122 has a substantially rotationally symmetric shape with respect to the central axis A ⁇ b> 1 of the tube wall 121.
  • the distal end portion of the tube wall 121 is formed in a substantially inverted elliptical cone shape, and has a tapered shape in which the thickness of the tube wall 121 decreases as it goes downward.
  • the distal end surface 123 of the tube wall 121 is included in a plane orthogonal to the central axis A1 of the tube wall 121.
  • the front end surface 123 has an annular shape.
  • a plane including the distal end surface 123 of the tube wall 121 is denoted by reference symbol P1.
  • w1 ⁇ 35 ⁇ m When the thickness of the tube wall 121 at the tip of the hollow needle 12 is w1, w1 ⁇ 35 ⁇ m. Note that w1 ⁇ 30 ⁇ m is preferable, w1 ⁇ 15 ⁇ m is more preferable, and w1 ⁇ 10 ⁇ m is further preferable.
  • R1 and r2 are measured using a digital microscope VHX-5000 manufactured by Keyence Corporation. More specifically, by specifying three points on the outer periphery of the distal end surface 123 on the image obtained by photographing the bottom surface (the surface including the distal end surface 123) of the tube wall 121 from the direction orthogonal to the bottom surface, A circle passing through the point is specified, and the diameter of this circle is r1. Similarly, by specifying three points on the inner periphery of the tip surface 123 on the same image, a circle passing through these three points is specified, and the diameter of this circle is set to r2.
  • the thickness w1 of the tip surface 123 that forms the spinneret 10a is thin. Therefore, the liquid separation from the tip surface 123 of the solution L1 that has passed through the flow path formed in the tube wall 121 is improved. As a result, the shape of the Taylor cone is stabilized, and further, the spinning jet is directed straight and straight toward the collector 20 without being broken into multiple pieces. Therefore, a fine fiber sheet can be manufactured stably, and even an oriented fine fiber sheet can be manufactured stably.
  • the ratio r of the thickness w1 to the inner diameter r2 of the tube wall 121 is preferably r ⁇ 15%, more preferably r ⁇ 10%, more preferably r ⁇ 5%, and r ⁇ 3%. More preferably.
  • the angle ⁇ of the tapered surface 122 with respect to the central axis A1 can be appropriately set within a range of 0 ° ⁇ ⁇ 90 °. However, 10 ° ⁇ ⁇ 80 ° is preferable, 15 ° ⁇ ⁇ 70 ° is more preferable, 20 ° ⁇ ⁇ 60 ° is further preferable, and 25 ° ⁇ ⁇ 50 °. It is more preferable that
  • the size of the inner diameter r2 is appropriately selected according to the diameter of the fine fiber to be manufactured and the material of the fine fiber, and the lower limit is preferably 0.10 mm ⁇ r2, more preferably 0.20 mm ⁇ r2. More preferably, 0.30 mm ⁇ r2.
  • the upper limit is preferably r2 ⁇ 5.0 mm, more preferably r2 ⁇ 3.0 mm, more preferably r2 ⁇ 2.0 mm, more preferably r2 ⁇ 1.0 mm, and more preferably r2 ⁇ 0.60 mm, and more preferably r2 ⁇ 0.50 mm.
  • the diameter of the fine fiber produced by the above spinning nozzle 10 is typically 100 nm to 500 ⁇ m, preferably 100 nm to 10 ⁇ m.
  • the outer surface of the tube wall 121 including the tapered surface 122 and the distal end surface 123 exposes a metal surface.
  • the distal end surface 123 of the tube wall 121 is a non-polished surface.
  • the electrospinning apparatus 1 as described above is prepared. Subsequently, the door 2a is opened, the syringe 3 is accessed, and the syringe 3 is filled with the solution L1 used as the raw material of the fine fiber, and then the door 2a is closed. Thereafter, the operation unit 8 is operated to drive the drive mechanisms 4 to 6 in an appropriate order. As a result, the collector 20 rotates at a predetermined rotational speed, and the solution L1 in the syringe 3 is supplied to the spinning nozzle 10 at a predetermined flow rate. Further, the spinning nozzle 10 reciprocates at a predetermined moving speed within a predetermined moving width in the left-right direction.
  • the spinning operation starts.
  • the solution L1 supplied into the spinning nozzle 10 stays in the vicinity of the spinning port 10a with surface tension and does not drop.
  • a high voltage for example, several kV to 30 kV
  • an electric field is generated using the hollow needle 12 and the collector 20 as electrodes.
  • the droplet of the solution L1 in the spinning nozzle 10 is positively charged and sucked toward the negatively charged collector 20 by the action of Coulomb force.
  • the solution L1 is jetted from the spinning port 10a toward the collector 20, and a spinning jet is formed.
  • the spinning jet is continuously wound around the collector 20.
  • the spinning nozzle 10 reciprocates in the left-right direction, an oriented fine fiber sheet having a predetermined width is formed on the surface of the collector 20.
  • the operation unit 8 is operated to turn off the power supply 30 and stop the driving mechanisms 4 to 6. Thereafter, the door 2 a is opened, and the oriented fine fiber sheet is removed from the collector 20. Thus, an oriented fine fiber sheet is produced.
  • the spinning nozzle 210 has a hollow needle 212 whose tube wall 221 has a constant thickness along the central axis direction, that is, a hollow needle as shown in FIGS. 1A to 1C.
  • the spinning nozzle 210 prepared at this time has the same structure as the spinning nozzle 10 that is finally manufactured, except that the thickness of the tube wall of the hollow needle is constant along the central axis direction.
  • the spinning nozzle 210 has the base portion 11 in addition to the hollow needle 212.
  • the cutting device 50 includes a lathe chuck 51 and a cutting tool 52. Further, the cutting device 50 includes a drive mechanism 53 for rotationally driving the lathe chuck 51, a drive mechanism 54 for positioning the cutting tool 52, and a control unit 55.
  • the control unit 55 can position the cutting tool 52 by rotating the lathe chuck 51 by controlling the drive mechanisms 53 and 54, respectively.
  • the structure of the drive mechanisms 53 and 54 is not specifically limited, It can comprise from a motor and a suitable mechanical element.
  • the drive mechanism 54 is driven manually or by the control unit 55 to position the cutting tool 52 on the side of the tip of the hollow needle 212 of the spinning nozzle 210 fixed to the lathe chuck 51 (FIG. 6). reference).
  • the cutting edge 52 a of the cutting tool 52 forms a slope inclined with respect to the central axis direction of the hollow needle 212. More specifically, the blade edge 52a is inclined so as to approach the hollow needle 212 from the left side toward the right side.
  • the right and left here are based on the state of FIG. 6, the right side is the tip side of the hollow needle 212, and the left side is the root side of the hollow needle 212. At this time, the right end of the blade edge 52a is positioned in the left-right direction at the tip of the hollow needle 212 or on the right side of it.
  • the drive mechanism 53 is driven by the control unit 55 to turn the lathe chuck 51 and the hollow needle 212 fixed thereto.
  • the rotation axis at this time is equal to the central axis of the tube wall 221.
  • the drive mechanism 54 is driven by the control unit 55 to move the cutting edge 52 a of the cutting tool 52 relative to the tip of the tube wall 221.
  • the cutting tool 52 is moved along the radial direction of the tube wall 221 toward the tube wall 221.
  • the cutting tool 52 advances in a direction substantially orthogonal to the central axis of the tube wall 221.
  • the cutting edge 52a reaches the outer surface of the tube wall 221 rotating at high speed, and the tip of the tube wall 221 is cut.
  • the cutting tool 52 is moved further along the radial direction of the tube wall 221.
  • the distal end portion of the tube wall 221 is cut along the slope of the cutting edge 52a, and the tapered surface 122 described above is formed at the distal end portion.
  • the control parameter controlled at this time does not have to be the amount of movement of the cutting edge 52a itself, but is any as long as the relative position with respect to the tube wall 221 reached by the cutting edge 52a can be determined. Also good.
  • the spinning nozzle 10 with w1 ⁇ 10 ⁇ m can be manufactured.
  • w1 ⁇ 10 ⁇ m means that w1 is infinitely close to zero, and substantially corresponds to the case where the distal end surface 123 is not formed on the tube wall 121. Therefore, when w1 ⁇ 10 ⁇ m, the position of the inner peripheral surface of the tube wall 221 along the radial direction of the tube wall 221 at a position C1 in the left-right direction in FIG. The cutting tool 52 is moved until the cutting edge 52a reaches.
  • the position C1 is the position of the distal end surface 223 of the hollow needle 212 before cutting.
  • the tube wall 221 is rotated at a high speed while positioning the blade edge 52a with respect to the distal end portion of the tube wall 221. Thereby, a tapered surface 122 is formed at the distal end portion of the tube wall 221.
  • the fine fiber sheet manufactured as described above can be used for various applications.
  • the fine fiber sheet can be used as a scaffold for various cells.
  • the cardiomyocyte sheet in which the cardiomyocytes are supported on the fine fiber sheet can have excellent maturity and stable functionality, and can be suitably used in transplantation, drug screening, and the like.
  • the spinning nozzle 210 is rotated in order to cut the tip of the spinning nozzle 210 with the cutting tool 52.
  • the cutting tool 52 may be rotated around the central axis of the spinning nozzle 210.
  • the spinning nozzle is not limited to the above-described cutting process, and can be manufactured by any processing method such as plastic processing or grinding.
  • Comparative Example 1 A spinning nozzle (jet needle straight type Black 22G) manufactured by BSA Sakurai Co., Ltd. was prepared and used as Comparative Example 1.
  • the inner diameter was 0.48 mm and the outer diameter was 0.7 mm.
  • the tube wall thickness w1 at the tip of the hollow needle calculated from the nominal size is 110 ⁇ m.
  • One spinning nozzle of Comparative Example 1 was prepared.
  • Comparative example 2 One more spinning nozzle of Comparative Example 1 was prepared, and the tip portion of each tube wall was cut into a tapered shape to obtain Comparative Example 2.
  • the thickness w1 of the tube wall at the tip of the hollow needle was about 40 ⁇ m (38.35 ⁇ m).
  • w1 here was measured by the measuring method mentioned above.
  • Example 1 One more spinning nozzle of Comparative Example 1 was prepared, and the tip of each tube wall was cut into a taper shape to obtain Example 1.
  • the thickness w1 of the tube wall at the tip of the hollow needle was about 30 ⁇ m (29.45 ⁇ m).
  • w1 here was measured by the measuring method mentioned above.
  • Example 2 One more spinning nozzle of Comparative Example 1 was prepared, and the tip of each tube wall was cut into a tapered shape to obtain Example 2.
  • the thickness w1 of the tube wall at the tip of the hollow needle was about 10 ⁇ m (10.95 ⁇ m).
  • w1 here was measured by the measuring method mentioned above.
  • Electrospinning apparatus 10 Spinning nozzle 10a Spinning port 12 Hollow needle 121 Tube wall 122 Tapered surface 123 Tip surface 20 Collector 30 Power supply 52 Cutting tool 52a Cutting edge w1 Thickness of the tube wall at the tip of the hollow needle

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Textile Engineering (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
  • Nonwoven Fabrics (AREA)

Abstract

L'invention concerne une filière qui est utilisée par un dispositif d'électrofilage pendant la fabrication d'une feuille de fibres fines, une feuille de fibres fines pouvant ainsi être fabriquée de façon stable. La filière est munie d'une aiguille creuse. L'aiguille creuse a une paroi de tube qui définit une ouverture de filage pour injecter une matière première formant un liquide pour la fibre fine. L'épaisseur de la paroi du tube au niveau de la pointe de l'aiguille creuse est inférieure ou égale 35 µm. Cette épaisseur est de préférence inférieure ou égale 30 µm, mieux encore inférieure ou égale 15 µm, et mieux encore inférieure ou égale à 10 µm.
PCT/JP2017/042544 2016-12-08 2017-11-28 Filière Ceased WO2018105438A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018554931A JP6944198B2 (ja) 2016-12-08 2017-11-28 紡糸ノズル

Applications Claiming Priority (2)

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JP2016238634 2016-12-08
JP2016-238634 2016-12-08

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WO2018105438A1 true WO2018105438A1 (fr) 2018-06-14

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Cited By (2)

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JP2021038493A (ja) * 2019-09-05 2021-03-11 株式会社東芝 電界紡糸ヘッド及び電界紡糸装置
JP2023505275A (ja) * 2019-12-05 2023-02-08 ジョン－ス パク， ノズル詰まり防止手段を備えるノズルブロック及びそれを備える電界紡糸装置

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JP2016053230A (ja) * 2014-09-04 2016-04-14 富士フイルム株式会社 電界紡糸ノズル、ナノファイバ製造装置及び方法

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JP2021038493A (ja) * 2019-09-05 2021-03-11 株式会社東芝 電界紡糸ヘッド及び電界紡糸装置
JP7374672B2 (ja) 2019-09-05 2023-11-07 株式会社東芝 電界紡糸ヘッド及び電界紡糸装置
JP2023505275A (ja) * 2019-12-05 2023-02-08 ジョン－ス パク， ノズル詰まり防止手段を備えるノズルブロック及びそれを備える電界紡糸装置
JP7462984B2 (ja) 2019-12-05 2024-04-08 ジョン－ス パク， ノズル詰まり防止手段を備えるノズルブロック及びそれを備える電界紡糸装置

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