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WO2018100176A1 - Cartouche pour capteur biochimique - Google Patents

Cartouche pour capteur biochimique Download PDF

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Publication number
WO2018100176A1
WO2018100176A1 PCT/EP2017/081221 EP2017081221W WO2018100176A1 WO 2018100176 A1 WO2018100176 A1 WO 2018100176A1 EP 2017081221 W EP2017081221 W EP 2017081221W WO 2018100176 A1 WO2018100176 A1 WO 2018100176A1
Authority
WO
WIPO (PCT)
Prior art keywords
disposable
removable cartridge
support device
sensing area
anyone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/081221
Other languages
English (en)
Inventor
Julien FILS
Haytem JARRAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metemis Development
Original Assignee
Metemis Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metemis Development filed Critical Metemis Development
Publication of WO2018100176A1 publication Critical patent/WO2018100176A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
    • A61B5/15149—Arrangement of piercing elements relative to each other
    • A61B5/15153—Multiple piercing elements stocked in a single compartment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6824—Arm or wrist
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

Definitions

  • the present invention relates to systems, devices and the use of such systems and devices for monitoring blood or interstitial fluid component or properties.
  • the invention relates to systems or devices continuously monitoring the level of blood or interstitial fluid components or blood properties.
  • BACKGROUND OF INVENTION Monitoring of physiologic parameters is a high demand for patient in the medical field for athletes or patients who want to follow continuously or substantially continuously their health status.
  • the more standard method consists in taking a blood sample from a patient and sending this sample to a laboratory in order to perform tests.
  • Continuous monitoring sensors are generally implanted subcutaneously and measure glucose levels in the interstitial fluid at various periods throughout the day, providing data that show trends in glucose measurements over a short period of time. These sensors are painful during insertion and usually require the assistance of a health care professional. Further, these sensors are intended for use during only a short duration (e.g., monitoring for a matter of days to determine a blood sugar pattern).
  • the document WO 02/091922 teaches a portable interstitial fluid monitoring device.
  • This device comprises microneedles, a diaphragm pump to extract interstitial fluid from the skin, and a sensor that detects the concentration of the fluid.
  • Said device comprises a color interrogation window and an optical sensor.
  • This device comprises many drawbacks. Indeed it requires assistance or handling after each use to change the microneedles or the color interrogation window. Furthermore, such device is able to measure the level of glucose in the blood but is not able to measure a plurality of different biological parameters.
  • the document WO 2008/077147 discloses an apparatus for continuous glucose monitoring of a patient including a plurality of cylindrical tissue piercing elements allowing the diffusion of glucose from the interstitial fluid into a sensing area.
  • this device does not permit to remove the sensors without throwing out the entire device.
  • this device is able to monitor the glucose level in blood but does not enable an athlete to monitor a plurality of biological parameters.
  • the purpose of the present invention is to provide a system which enables the monitoring of one or several biochemical parameters within the blood or within the interstitial fluid of a mobile person without pain by means of removable and replaceable sensors.
  • the present invention relates to a disposable and removable cartridge configured to cooperate with a wearable support device, said wearable support device comprising securing means configured to secure the wearable support device to the skin of a subject, at least one connection track and at least one first positioning means;
  • said disposable and removable cartridge comprising:
  • microfluidic circuit in fluid communication with said at least one microneedle and with said sensing area
  • At least one sensor adapted to monitor at least one parameter of a fluid within the sensing area
  • the disposable and removable cartridge further comprises a pumping means fluidly connected to the sensing area and ensuring the flow of the fluid in at least said microfluidic circuit and said sensing area.
  • the disposable and removable cartridge further comprises a waste receiver in fluid communication with said sensing area.
  • said pumping means is fluidly connected between the sensing area and the waste receiver or said waste receiver is fluidly connected between the sensing area and the pumping means.
  • said waste receiver comprises on at least a part of its surface, an opening comprising a material, wherein said material is hermetic to the liquid and permeable to the steam.
  • said material is a Gortex®.
  • the waste receiver further comprises solid foam.
  • said pumping means is a piezoelectric pump, a peristaltic pump or a diaphragm pump.
  • the fluid is blood or interstitial fluid.
  • the disposable and removable cartridge further comprises at least one microfluidic chamber, at least one additional microneedle and an additional microfluidic circuit fluidly connected to said at least one additional microneedle and said microfluidic chamber.
  • the additional microfluidic circuit and the microfluidic circuit are fluidly connected. In one embodiment, the additional microfluidic circuit and the microfluidic circuit are not fluidly connected.
  • said microfluidic chamber comprises substances to be injected on the skin of a subject.
  • the disposable and removable cartridge further comprises an additional pumping means fluidly connected to the microfluidic chamber.
  • said at least one sensor is an optical sensor or an electrochemical sensor.
  • the disposable and removable cartridge further comprises a printed circuit board, wherein said at least one sensor and said second connection track are electrically connected to said printed circuit board.
  • said at least one sensor is adapted to monitor the concentration of a component in the fluid within the sensing area.
  • said at least one sensor is adapted to monitor the concentration of glucose or lactate ions in the fluid within the sensing area. In one embodiment, said at least one sensor is adapted to monitor the concentration of hormones such as estrogen or estradiol within the sensing area.
  • said at least one sensor is adapted to monitor the conductivity, the density, or the temperature of the fluid within the sensing area.
  • the disposable and removable cartridge further comprises a liquid detector fluidly connected to the microfluidic circuit.
  • the disposable and removable cartridge further comprising a fluid receiver fluidly connected to the sensing area and further comprising a membrane fluidly connected between said sensing area and said fluid receiver.
  • the pores of said membrane have a length or a diameter ranging from lnm to K ⁇ m.
  • the porosity is a barrier for elements which have a molecular weight higher than a value ranging from 1 to 1500 Da.
  • the present invention also relates to a wearable support device, configured to cooperate with the disposable and removable cartridge according to the present invention; said wearable support device comprising:
  • - securing means configured to secure the wearable support device to the skin of a subject
  • At least one first positioning means configured to interact with the at least one second positioning means of said disposable and removable cartridge in such a way the at least one first connection track of the support device is connected at said at least one second connection track of the disposable and removable cartridge, and in such a way the cartridge is releasably secured to the wearable support device.
  • said securing means comprises a strip, an armband, a wristwatch, an elastic band, or an adhesive.
  • the wearable support device further comprises a microcontroller configured to calculate the concentration of the component measured by the at least one sensor of the disposable and removable cartridge.
  • the wearable support device further comprises a display connected to the microcontroller.
  • the present invention also relates to a system comprising the disposable and removable cartridge according to the present invention, and the wearable support device according to the present invention.
  • said disposable and removable cartridge is inserted in said wearable support device by rotation or by pressure.
  • the first positioning means is a clip, a screw, a hook, a loop or an adhesive.
  • the second positioning means is a clip, a screw, a hook, a loop or an adhesive.
  • first positioning means are male means and the second positioning means are female means or conversely.
  • system further comprises an elastic element between the disposable and removable cartridge and the wearable support device.
  • said elastic element is a spring.
  • Microcroneedle refers to a substantially cylindrical or pyramidal tissue piercing element having a distal opening, a proximal opening, and an interior lumen extending from the distal opening to the proximal opening.
  • Disposable refers to a device designed to be thrown away after being used, or after a short-time utilization.
  • Removable refers to a device designed to be moved, dislodged and replaced in its position.
  • the present invention relates to a disposable and removable cartridge 1 configured to cooperate with a wearable support device 2, said wearable support device 2 comprising securing means 21 configured to secure the wearable support device 2 to the skin of a subject, at least one connection track and at least one first positioning means.
  • the disposable and removable cartridge 1 according to the present invention, configured to cooperate with a wearable support device 2, said wearable support device 2 comprising securing means 21 configured to secure the wearable support device 2 to the skin of a subject, at least one connection track and at least one first positioning means.
  • said cartridge 1 comprises:
  • microfluidic circuit in fluid communication with said at least one microneedle 11 and with said sensing area 12;
  • At least one sensor 121 adapted to monitor at least one parameter of a fluid within the sensing area 12;
  • connection track 123 electrically connected to the at least one sensor 121
  • At least one second positioning means configured to cooperate with the at least one first positioning means of the wearable support device 2 in such a way that when cooperates, the at least one first connection track of the wearable support device 2 is connected to said at least one second connection track 123 of the disposable and removable cartridge 1, and the cartridge is releasably secured to the wearable support device 2.
  • Said disposable and removable cartridge 1 is configured to be secured to a wearable support device 2 and said wearable support device 2 comprising securing means configured to secure the wearable support device 2 to the skin of a subject in such a way that the at least one microneedle is in contact, in front of the skin of said subject, or in such a way that the at least one microneedle penetrates the skin of said subject.
  • said disposable and removable cartridge 1 comprises a matrix of microneedles.
  • the at least one microneedle is on a substrate and the at least one microneedle forms with said substrate an angle ranging from 35 to 90° such that said at least one microneedle penetrates the skin at a 35° to 90° angle.
  • the disposable and removable cartridge 1 comprises a pumping means 13 fluidly connected to the sensing area 12 and ensuring the flow of the fluid in at least said microfluidic circuit and said sensing area 12.
  • This pumping means 13 pumps the fluid from the microfluidic circuit to the sensing area 12 to be analyzed.
  • the microfluidic circuit does not comprise pumping means and the fluid fills the microfluidic circuit by capillarity.
  • the microfluidic circuit comprise a foam, narrow surface, capillary tubes or a to ensure the motion of the fluid along the microfluidic circuit via capillarity.
  • the pumping means 13 is configured to be used in both ways: aspiring the fluid from the microfluidic circuit to the sensing area 12 and pushing the fluid through the sensing area 12, the microfluidic circuit and the at least one microneedle 11. This embodiment permits to wash the microfluidic circuit, the at least one microneedle 11 and the sensing area 12 after use.
  • the pumping means 13 is also fluidly connected to a chamber containing a washing liquid.
  • the washing liquid is a sterilization liquid.
  • the washing liquid is peracetic acid or ethanol.
  • the pumping means 13 is able to be inverted in such a way that the pumping means 13 can empty the waste receiver 14, the sensing area and/or the microfluidic circuit.
  • the microfluidic circuit is connected to a waste receiver after arranged to receive the washing liquid after the washing.
  • the microfluidic circuit comprises at least one sterilization element.
  • the sterilization element irradiates the microfluidic circuit with UV light to sterilize said microfluidic circuit.
  • the sterilization element is an Ultraviolet Light Emitting Diode (also called UV LED).
  • the microfluidic circuit comprise an array of UV LED along the length of the microfluidic circuit.
  • the present cartridge 1 is removable, which permits the user to use different cartridges, each comprising different sensors 121 for monitoring different components or fluid parameters, keeping the same wearable support device 2.
  • the disposable and removable cartridge 1 comprises a waste receiver 14 in fluid communication with said sensing area 12. Said waste receiver 14 receives the fluid after being passed within the sensing area 12. According to one embodiment, the waste receiver 14 stocks the fluid components and the water or the volatile parts of the fluid that can evaporate.
  • the pumping means 13 is fluidly connected between the sensing area 12 and the waste receiver 14 (figures 2 and 4) or said waste receiver 14 is fluidly connected between the sensing area 12 and the pumping means 13 (figure 3).
  • the waste receiver 14 comprises on at least a part of its surface, an opening 141 comprising a material.
  • said material is hermetic to the liquid and permeable to the steam.
  • said material is a Gortex® . This embodiment allows the water or the volatile component of the fluid to evaporate and the waste receiver 14 is still hermetic to the liquid and dust.
  • the waste receiver 14 also comprises solid foam.
  • the solid foam is located inside the waste receiver 14 to be in contact with the fluid. This solid foam increases the surface between the fluid and the air, increasing the speed of evaporation of water or volatile components within the fluid.
  • said pumping means 13 is a piezoelectric pump, a peristaltic pump or a diaphragm pump.
  • the fluid is blood or interstitial blood.
  • the components of the blood or the interstitial fluid to be monitored do not move to the sensing chamber 12 by diffusion.
  • the sensors can be dried before two measurements. Such feature increases the lifetime of said sensors.
  • the fluid is sampled from the skin of a subject by the at least one microneedle.
  • the disposable and removable cartridge 1 further comprises at least one microfluidic chamber 15, at least one additional microneedle 16 and an additional microfluidic circuit fluidly connecting said at least one additional microneedle 16 to said microfluidic chamber 15.
  • said microfluidic chamber 15 comprises substances to be injected on the skin of a subject.
  • the disposable and removable cartridge 1 further comprises an additional pumping means 17 fluidly connected to the microfluidic chamber 15.
  • This microfluidic chamber 15 and additional elements permit the injection of a substance to the subject.
  • this substance could be insulin. Therefore, the cartridge 1 is able, for example, to inject insulin in function of the glucose concentration in the blood or in the interstitial fluid of said subject monitored by the at least one sensors of the sensing area.
  • the additional microfluidic circuit and the microfluidic circuit are fluidly connected. According to one embodiment, the additional microfluidic circuit and the microfluidic circuit are not fluidly connected.
  • said at least one sensor 121 is connected to a printed circuit board.
  • said printed circuit board is also connected to the second connection track 123 of the cartridge 1 configured to be connected to the first track of the wearable support device 2.
  • the at least one sensor 121 is connected to the second connection track 123.
  • the connection track s located on the exterior surface of the cartridge 1.
  • the pumping means is located on the wearable support device.
  • said at least one sensor 121 is adapted to monitor the concentration of a component in the fluid within said sensing area 12.
  • said at least one sensor 121 is adapted to monitor the concentration of glucose or lactate ions in the fluid within the sensing area 12.
  • said at least one sensor 121 is adapted to monitor the concentration of hormones such as estrogen or estradiol.
  • said at least one sensor 121 is adapted to monitor the conductivity, the density, or the temperature of the fluid within said sensing area 12.
  • said at least one sensor 121 is an optical sensor or an electrochemical sensor.
  • the disposable and removable cartridge 1 further comprises a liquid detector fluidly connected to the microfluidic circuit. This liquid detector can advise the subject that the disposable and removable cartridge 1 is working.
  • the liquid detector detects the presence of the fluid in the circuit.
  • the liquid detector is in the sensing chamber.
  • the liquid detector is an electrochemical sensor and said electrochemical sensor detects the fluid when a tension can be measured between its electrodes.
  • the liquid detector is an optical sensor which detects the presence of the liquid when the signal received by said optical sensor is different from the baseline signal.
  • the at least one sensor within the sensing chamber is the liquid detector.
  • the at least one sensor and the liquid detector are two different elements.
  • the at least one sensor and the liquid detector comprise two or three electrodes.
  • the liquid detector is the reference electrode and the at least one sensor comprises at least two working electrodes.
  • the working electrodes are located in the microfluidic circuit between the microneedles 11 and the reference electrode. In said embodiment, the device ensure that the microfluidic circuits filled and the sensors 121 are fluidly covered when the measure occurs.
  • the disposable and removable cartridge 1 comprises a fluidic receiver 182 fluidly connected to the sensing area 12 and further comprises a membrane 18 fluidly connected to the microfluidic circuit between the sensing area 12 and said fluid receiver 182.
  • the membrane 18 filters the fluid.
  • the water and the ions in the fluid pass through the membrane 18 while the solid components, or cells are stopped by the membrane 18.
  • the membrane 18 comprises pores having a very small porosity.
  • the porosity is a barrier for elements which have a molecular weight higher than a value ranging from 1 to 1500 Da.
  • the pores of the membrane 8 have a length or a diameter ranging from 1 nm to 10 ⁇ m, from lnm to 1 ⁇ m or from lnm to 100nm.
  • the disposable and removable cartridge 1 further comprises a valve 181 and/or a second pumping means 13, ensuring the guidance of the fluid to the fluid receiver.
  • the liquid within the fluid receiver 182 can be reused to clean the sensing area 12 and the microfluidic circuit, for example using pumping means 13 and valves 181, 183.
  • the invention further relates to a wearable support device 2, configured to cooperate with the disposable and removable cartridge 1 according to the present invention.
  • the wearable support device 2 configured to cooperate with the disposable and removable cartridge 1 according to the present invention, comprises:
  • - securing means 21 configured to secure the wearable support device 2 to the skin of a subject
  • At least one first positioning means configured to cooperate with the at least one second positioning means of said disposable and removable cartridge 1 in such a way that when cooperates, the at least one first connection track of the support device is connected at said at least one second connection track 123 of the disposable and removable cartridge 1 , and that the cartridge is releasably secured to the wearable support device 2.
  • This wearable support 2 can be a watch.
  • said securing means 21 comprises a strip, an armband, a wristwatch, an elastic band, or an adhesive.
  • the securing means 21 are arranged to maintain the contact between the cartridge 1 and the skin of the subject.
  • the wearable support device 2 further comprises a microcontroller configured to calculate the concentration of the component measured by the at least one sensor of the disposable and removable cartridge 1.
  • the wearable support device 2 further comprises a display 22 connected to the microcontroller. The display 22 can show to the subject the parameters of the fluid monitored by the at least one sensor 121 in the cartridge 1.
  • the wearable support device 2 comprises other means of information to inform or alert the subject of its health status (for example, vibrations).
  • the present invention also relates to a system 3 comprising the disposable and removable cartridge 1 and the wearable support device 2 according to the present invention.
  • said disposable and removable cartridge 1 is inserted in said wearable support device 2 by rotation or by pressure.
  • the first or the second positioning means is a clip, a screw, a hook, a loop or an adhesive.
  • the first positioning means are male means and the second positioning means are female means or conversely.
  • the wearable support device 2 further comprises a battery and the system 3 is autonomous and mobile.
  • the system 3 further comprises an elastic element between the disposable and removable cartridge 1 and the wearable support device 2 such as a spring.
  • This elastic element permits the subject, applying a pressure on the system 3, to displace the disposable and removable cartridge 1 relative to the wearable support device 2 and to allow the at least one microneedle 11 to penetrate in the skin of the subject which wears the system 3.
  • Figure 1 is a schematic drawing of the disposable and removable cartridge according to one embodiment.
  • Figure 2 is a schematic drawing of the disposable and removable cartridge comprising a waste receiver according to one embodiment.
  • Figure 3 is a schematic drawing of the disposable and removable cartridge comprising a waste receiver located between the sensing area and the pumping means.
  • Figure 4 is a schematic drawing of the disposable and removable cartridge having a cylindrical geometry.
  • Figure 5 is a drawing of the system according to one embodiment, wherein the wearable support device 2 is a watch.
  • Figure 6 is a schematic drawing of the disposable and removable cartridge comprising a microfluidic chamber containing a substance.
  • Figure 7 is a schematic drawing of the waste receiver, wherein the fluidic connections are not represented.
  • FIG 8 is a schematic drawing of the disposable and removable cartridge according to one embodiment wherein said cartridge comprises a membrane and a fluid receiver with a second pumping element.
  • FIG. 9 is a schematic drawing of the disposable and removable cartridge according to one embodiment wherein said cartridge comprises a membrane and a fluid receiver with at least one valve.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne une cartouche jetable et amovible (1) configurée pour coopérer avec un dispositif de support pouvant être porté, ledit dispositif de support pouvant être porté comprenant des moyens à fixer à la peau d'un sujet, au moins une voie de connexion et au moins un premier système de positionnement ; ladite cartouche jetable et amovible (1) comprenant : au moins une micro-aiguille (11) ; une zone de détection (12) ; un circuit microfluidique en communication fluidique avec ladite au moins une micro-aiguille (11) et avec ladite zone de détection (12) ; au moins un capteur (121) conçu pour surveiller au moins un paramètre d'un fluide fourni par le patient, dans la zone de détection (12) ; une seconde voie de connexion (123) connectée électriquement à l'au moins un capteur (121) ; au moins un second système de positionnement configuré pour coopérer avec l'au moins un premier système de positionnement du dispositif de support de telle sorte que l'au moins une première voie de connexion du dispositif de support est connectée au niveau de ladite au moins une seconde voie de connexion (123) de la cartouche jetable et amovible (1), et de telle sorte que la cartouche est fixée de manière amovible au dispositif de support pouvant être porté. La présente invention concerne également un dispositif de support pouvant être porté correspondant et un système comprenant une telle cartouche jetable et amovible (1) et un tel dispositif de support pouvant être porté.
PCT/EP2017/081221 2016-12-02 2017-12-01 Cartouche pour capteur biochimique Ceased WO2018100176A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662429210P 2016-12-02 2016-12-02
US62/429,210 2016-12-02

Publications (1)

Publication Number Publication Date
WO2018100176A1 true WO2018100176A1 (fr) 2018-06-07

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PCT/EP2017/081221 Ceased WO2018100176A1 (fr) 2016-12-02 2017-12-01 Cartouche pour capteur biochimique

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WO (1) WO2018100176A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111948930A (zh) * 2020-09-02 2020-11-17 中国科学院深圳先进技术研究院 旋转式传感器芯片阵列盘及使用其的智能可穿戴手表
FR3106050A1 (fr) * 2020-01-14 2021-07-16 Pkvitality Bracelet pour dispositif de surveillance corporelle

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002091922A1 (fr) 2001-05-11 2002-11-21 The Procter & Gamble Company Systeme de surveillance de fluide interstitiel portable
EP1260815A2 (fr) * 2001-05-25 2002-11-27 Lifescan, Inc. Méthode pour la surveillance automatique d'une concentration d'analyte au moyen de dispositifs d'intervention invasive minimum
EP1661516A1 (fr) * 2003-09-02 2006-05-31 Koji Sode Detecteur de glucose et appareil a en mesurer le niveau
WO2006115663A2 (fr) * 2005-04-25 2006-11-02 Honeywell International Inc. Systeme de regulation de flux pour cartouche
WO2008077147A2 (fr) 2006-12-20 2008-06-26 Arkal Medical, Inc. Dispositifs, systèmes, procédés et outils pour la surveillance continue du glucose
US20130274568A1 (en) * 2005-09-30 2013-10-17 Intuity Medical, Inc. Fully integrated wearable or handheld monitor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002091922A1 (fr) 2001-05-11 2002-11-21 The Procter & Gamble Company Systeme de surveillance de fluide interstitiel portable
EP1260815A2 (fr) * 2001-05-25 2002-11-27 Lifescan, Inc. Méthode pour la surveillance automatique d'une concentration d'analyte au moyen de dispositifs d'intervention invasive minimum
EP1661516A1 (fr) * 2003-09-02 2006-05-31 Koji Sode Detecteur de glucose et appareil a en mesurer le niveau
WO2006115663A2 (fr) * 2005-04-25 2006-11-02 Honeywell International Inc. Systeme de regulation de flux pour cartouche
US20130274568A1 (en) * 2005-09-30 2013-10-17 Intuity Medical, Inc. Fully integrated wearable or handheld monitor
WO2008077147A2 (fr) 2006-12-20 2008-06-26 Arkal Medical, Inc. Dispositifs, systèmes, procédés et outils pour la surveillance continue du glucose

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3106050A1 (fr) * 2020-01-14 2021-07-16 Pkvitality Bracelet pour dispositif de surveillance corporelle
CN111948930A (zh) * 2020-09-02 2020-11-17 中国科学院深圳先进技术研究院 旋转式传感器芯片阵列盘及使用其的智能可穿戴手表

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